A radiopaque contrast medium for use in angiography of cadavers and a method for its preparation

Abstract

The application belongs to the technical field of angiographic agents, and particularly relates to a kind of angiographic agents for corpses and a preparation method thereof. The angiographic agent for corpses comprises the following components in parts by mass: 20-35 parts of iodine-containing polymer, 30-50 parts of iodinated benzene ring compound, 90-150 parts of glycerol triacetate, 30-40 parts of dimer acid, and 600-800 parts of liquid paraffin. The iodine-containing polymer is obtained by copolymerization of (meth) acrylic acid C4-6 alkyl ester, polyethylene glycol bisacrylate and iodine-containing monomer, and the iodine-containing monomer is selected from at least one of 3-iodine-acrylic acid ethyl ester, 3-iodine-acrylic acid methyl ester and (meth) acrylic acid iodinated benzyl ester. The angiographic agent can achieve excellent angiographic effect on corpses, and can also achieve ideal angiographic effect for necropsy of corpses with long death time, thereby providing strong support for necropsy.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of angiographic agents, and particularly relates to a kind of angiographic agents for cadavers and a preparation method thereof. BACKGROUND

[0002] In traditional cadaver dissection, the search for vascular lesions and injuries is one of the technical problems that have puzzled the forensic community. In traditional cadaver dissection, if thin-layer sectioning of blood vessels is used for blood vessel search, not only a large amount of manpower and material resources are consumed, but also due to the limitations of naked eye observation, it often leads to missed detection, and even misdiagnosis. With the development of cadaver angiography technology, this problem has been improved and even solved. Cadavers lack the blood circulation of living bodies, so whole-body angiography of cadavers is extremely challenging. In addition, the dosage of angiographic agents for cadavers is large, and the current clinical use of iodine contrast agents, such as iodized oil, is relatively expensive, and there is a problem of incomplete angiography or pseudo-image caused by viscosity mismatch. Compared with conventional angiographic agents, angiographic agents for cadavers have their own characteristics, such as increased vascular wall permeability due to loss of physiological activity in cadaver blood vessels, which can easily lead to extravasation of contrast agents and affect imaging quality. Therefore, cadaver contrast agents need to have high viscosity and liposolubility to slow down the penetration rate and stabilize the filling of blood vessels.

[0003] Iohexol is a commonly used component of angiographic agents for cadavers in clinical use. For example, CN114010804A discloses a kind of angiographic agent for cadavers, which includes iohexol, sorbitol and water. The content of iohexol in the angiographic agent is 20-60 mg / mL, and the content of sorbitol in the angiographic agent is 700-800 mg / mL. Iohexol is prone to extravasate from the cadaver blood vessel wall to the surrounding tissue, resulting in blurred blood vessel boundaries, decreased contrast quality, and insufficient contrast density of iohexol, which cannot meet the requirements of stable influence of cadaver blood vessels for a long time.

[0004] CN111840580A discloses a kind of angiographic agent for cadavers, which includes an iodinated benzene ring compound and a specific viscosity liposoluble solvent, and the iodinated benzene ring compound is mixed with the specific viscosity liposoluble solvent to obtain a liposoluble iodine solution. US20130045168A1 discloses an angiographic agent that can be used for autopsy, which includes iodized oil and a non-polar component, and the non-polar component is paraffin oil or liquid paraffin, and the two are mixed to obtain a liposoluble iodine solution. However, the above-mentioned contrast agent using small-molecule organic iodide has poor flowability at low temperature, cannot be used in a wide range of temperature, and has the problem of incomplete contrast during the contrast process.

[0005] The more important problem of the existing corpse angiographic agent is that the existing angiographic agent has a high requirement for the sample death time, which is 12h, and the best angiographic effect is generally not more than 24h. The blood vessels are complete within 12h of death. With the passage of time, the permeability of the blood vessels of the corpse increases, affecting the filling of the vascular filling agent, and permeation is prone to occur. SUMMARY

[0006] In order to solve the defect that the existing angiographic agent for corpses and autopsies has a high requirement for the sample death time (the death time is generally not more than 48h, preferably not more than 24h), and the angiographic effect decreases when the death time is more than 3 days, the present application provides a corpse angiographic agent and a preparation method thereof. The corpse angiographic agent provided by the present application contains iodine-containing polymer, iodinated benzene ring compound and glyceryl triacetate. The present application adopts the compounding of iodine-containing polymer and iodinated benzene ring compound. The iodine-containing polymer forms micelles at a verified concentration, provides more excellent angiographic effect, has better low-temperature fluidity, and does not cause problems such as vascular permeation. The dimeric acid can form a water-based isolation film on the inner surface of the blood vessel, hinder the permeation of the angiographic agent to the outside of the blood vessel, and enhance the stability of the angiographic agent component in the blood vessel. The glyceryl triacetate as a low-temperature plasticizer can provide a suitable viscosity for the angiographic agent at low temperature, and can also have an ideal angiographic effect on corpses with a long death time in cooperation with the iodine-containing polymer. Specifically, the present application provides the following technical solutions to solve the above technical problems:

[0007] A corpse angiographic agent, comprising the following components in parts by mass: 20-35 parts of iodine-containing polymer, 30-50 parts of iodinated benzene ring compound, 90-150 parts of glyceryl triacetate, 30-40 parts of dimeric acid, and 600-800 parts of liquid paraffin; the iodine-containing polymer is obtained by copolymerization of (meth) acrylic acid alkyl ester, polyethylene glycol diacrylate and iodine-containing monomer; the alkyl carbon chain length in the (meth) acrylic acid alkyl ester is 4-6; the iodine-containing monomer is selected from at least one of 3-iodo-acrylic acid ethyl ester, 3-iodo-acrylic acid methyl ester and (meth) acrylic acid iodinated benzyl ester.

[0008] Further, the iodinated benzene ring compound is at least one of mono-iodinated benzene ring compound, di-iodinated benzene ring compound, tri-iodinated benzene ring compound, tetra-iodinated benzene ring compound, penta-iodinated benzene ring compound and hexa-iodinated benzene ring compound; preferably, the di-iodinated benzene ring compound. Further, the di-iodinated benzene ring compound is selected from at least one of 1,2-diiodobenzene, 1,3-diiodobenzene and 1,4-diiodobenzene.

[0009] Further, the molar ratio of (meth) acrylic acid alkyl ester, polyethylene glycol diacrylate and iodine-containing monomer is 6-10:0.5-0.8:3-5.

[0010] Further, the (meth)acrylic acid iodo benzyl ester is selected from at least one of (meth)acrylic acid 3,4,5-triiodobenzyl ester, (meth)acrylic acid 3-iodobenzyl ester, (meth)acrylic acid 2-iodobenzyl ester, (meth)acrylic acid 3,5-diiodobenzyl ester.

[0011] Further, the (meth)acrylic acid iodo benzyl ester is prepared by esterification reaction of (meth)acrylic acid and iodo benzyl alcohol, and the iodo benzyl alcohol is selected from at least one of 3,4,5-triiodobenzyl alcohol, 3-iodobenzyl alcohol, 2-iodobenzyl alcohol, 3,5-diiodobenzyl alcohol.

[0012] Further, the preparation method of the (meth)acrylic acid iodo benzyl ester comprises the following steps: under inert atmosphere, (meth)acrylic acid and iodo benzyl alcohol are added into aromatic hydrocarbon organic solvent, and the product (meth)acrylic acid iodo benzyl ester is obtained by fully reacting under the presence of concentrated sulfuric acid catalyst and polymerization inhibitor at 70-110℃. The generated water is removed by water trap during the reaction, and after the reaction is completed, neutralization, liquid separation, extraction and reduced pressure distillation are performed; the neutralization is adjusted to pH 6-7 by sodium bicarbonate to neutralize the excess acid; the extraction is performed by ethyl acetate.

[0013] Preferably, the molar ratio of (meth)acrylic acid and iodo benzyl alcohol is 1-1.2:1; the aromatic hydrocarbon organic solvent is selected from at least one of benzene, toluene and ethylbenzene; the inert atmosphere is nitrogen, the amount of concentrated sulfuric acid catalyst is 2-5wt% of the mass of (meth)acrylic acid, and the polymerization inhibitor is selected from at least one of hydroquinone, p-hydroxyanisole, p-methoxyphenol and tert-butyl catechol, and the amount of polymerization inhibitor is 0.3-1wt% of the mass of (meth)acrylic acid.

[0014] Further, the (meth)acrylic acid alkyl ester is selected from at least one of (meth)acrylic acid propyl ester, (meth)acrylic acid butyl ester, (meth)acrylic acid pentyl ester and (meth)acrylic acid hexyl ester; the inventors have also tried to use (meth)acrylic acid C1-3 ester, but the effect is not good, the carbon chain length is insufficient, and at least (meth)acrylic acid butyl ester is needed to obtain a good effect; however, the carbon chain length cannot be too long, otherwise the solubility is not good and the iodine-containing polymer cannot be well dispersed in liquid paraffin. The number average molecular weight of the PEG segment of the polyethylene glycol diacrylate is 200-400 g / mol.

[0015] Further, the iodine-containing polymer is prepared by a preparation method comprising the following steps: under inert atmosphere, (meth)acrylic acid C3-6 alkyl ester, polyethylene glycol diacrylate and iodine-containing monomer are added into an organic solvent, an initiator is slowly added while being heated to 70-80℃, and the reaction is performed for 6-10h; after the reaction is completed, the reaction solution is poured into methanol, the polymer is precipitated, washed and dried to obtain the iodine-containing polymer.

[0016] Further, the organic solvent is selected from at least one of tetrahydrofuran, ethyl acetate, butyl acetate; the initiator is an azo initiator, and is specifically selected from at least one of azobisisobutyronitrile, azobisisoheptyl nitrile, dimethyl azobis isobutyrate, and the amount of the initiator is 1-3 wt% of the total mass of the monomers; the washing is washing with methanol for 3-5 times, and the drying is vacuum drying.

[0017] Further, the acid value of the dimer acid is 180-210 mgKOH / g, and the viscosity at 25 DEG C is 4000-7000 mPa s; the viscosity of the liquid paraffin at 25 DEG C is 10-40 mPa s.

[0018] The application further provides a preparation method of the angiographic agent for corpses.

[0019] (S1) accurately weighing each material, stirring and uniformly mixing the iodobenzene ring compound and the liquid paraffin to obtain liquid phase A;

[0020] (S2) uniformly mixing the iodine-containing polymer, glyceryl triacetate and dimer acid under heating at 50-60 DEG C to obtain liquid phase B;

[0021] (S3) uniformly mixing liquid phase A and liquid phase B under stirring at 300-600 rpm, vacuum degassing to obtain the angiographic agent for corpses, and storing in a light-proof manner.

[0022] Further, the uniformly mixing under ultrasonic conditions is stirring or oscillation under ultrasonic conditions, the ultrasonic power is 200-300 W, and the ultrasonic frequency is 60-200 kHz; the vacuum degassing is under 0.01-0.1 MPa for 0.5-2 h.

[0023] The iodine-containing polymer prepared by the application can realize excellent angiographic effect on corpses in cooperation with the iodobenzene ring compound, and the angiographic agent of the application can still achieve ideal angiographic effect for corpses with a longer death time, such as 72 h≤death time≤84 h, for which conventional angiographic agents for corpses have no effect, thereby providing strong support for autopsy work. BRIEF DESCRIPTION OF DRAWINGS

[0024] Figure 1 is an angiographic image of the arterial arch part of a human corpse with a death time of 12 h using the angiographic agent of example 1;

[0025] Figure 2 is an angiographic image of the arterial arch part of a human corpse with a death time of 72 h using the angiographic agent of example 1. DETAILED DESCRIPTION

[0026] The technical solutions of the application are further explained and described below with specific examples.

[0027] The acid value of the dimer acid is 196 mgKOH / g, and the viscosity at 25℃ is 4700 mPa·s; the viscosity of liquid paraffin at 25℃ is 10 mPa·s.

[0028] Preparation Example 1-1

[0029] Under a nitrogen atmosphere, 1.1 molar parts of methacrylic acid and 1 molar part of 3,4,5-triiodobenzyl alcohol were added to the solvent toluene, 3wt% of concentrated sulfuric acid of the mass of methacrylic acid was added as a catalyst, 0.6wt% of hydroquinone of the mass of methacrylic acid was added as a polymerization inhibitor, the temperature was raised to 100℃ and reacted for 12h, the water was separated by a water separator, neutralized to pH=7 with 5wt% sodium bicarbonate aqueous solution, separated, the aqueous phase was extracted with ethyl acetate, the organic phases were combined, the solvent was distilled off under reduced pressure, and 3,4,5-triiodobenzyl methacrylate was obtained.

[0030] Preparation Example 1-2

[0031] The other conditions are the same as those in Preparation Example 1-1, except that 3,4,5-triiodobenzyl alcohol is replaced by 3,5-diiodobenzyl alcohol of equal molar amount, and the product is 3,5-diiodobenzyl methacrylate.

[0032] Preparation Example 1-3

[0033] The other conditions are the same as those in Preparation Example 1-1, except that 3,4,5-triiodobenzyl alcohol is replaced by 3-iodobenzyl alcohol of equal molar amount, and the product is 3-iodobenzyl methacrylate.

[0034] Preparation Example 2-1

[0035] Under a nitrogen atmosphere, butyl acrylate, polyethylene glycol diacrylate (PEG segment number average molecular weight 200) and the 3,4,5-triiodobenzyl methacrylate prepared in Preparation Example 1 were added to the solvent ethyl acetate in a molar ratio of 6:0.8:5, and 5wt% of azobisisobutyronitrile in ethyl acetate was slowly added dropwise while heating, and the amount of azobisisobutyronitrile added was 1wt% of the total mass of the monomers (the sum of isopropyl acrylate, polyethylene glycol diacrylate and 3,4,5-triiodobenzyl methacrylate). The temperature was raised to 80℃ and reacted for 10h. After the reaction was completed, the reaction solution was poured into methanol, and the polymer was precipitated, washed with tetrahydrofuran for 3 times, and vacuum dried to obtain iodine-containing polymer 1.

[0036] Preparation Example 2-2

[0037] The other conditions are the same as those in Preparation Example 2-1, except that the 3,4,5-triiodobenzyl methacrylate prepared in Preparation Example 1 is replaced by the 3,5-diiodobenzyl methacrylate prepared in Preparation Example 1-2, and finally iodine-containing polymer 2 is prepared.

[0038] Preparation Example 2-3

[0039] The other conditions were the same as in Preparation Example 2-1, except that the 3,4,5-triiodobenzyl methacrylate prepared in Preparation Example 1 was replaced with an equimolar amount of 3-iodobenzyl methacrylate prepared in Preparation Example 1-3, and finally, iodine-containing polymer 3 was prepared.

[0040] Preparation Example 2-4

[0041] The other conditions were the same as in Preparation Example 2-1, except that the molar ratio of butyl acrylate, polyethylene glycol diacrylate, and 3,4,5-triiodobenzyl methacrylate was changed to 10:0.5:3, and finally, iodine-containing polymer 4 was prepared.

[0042] Preparation Example 2-5

[0043] The other conditions were the same as in Preparation Example 2-1, except that butyl acrylate was replaced with an equimolar amount of propyl acrylate, and finally, iodine-containing polymer 5 was prepared.

[0044] Preparation Example 2-6

[0045] The other conditions were the same as in Preparation Example 2-1, except that butyl acrylate was replaced with an equimolar amount of hexyl acrylate, and finally, iodine-containing polymer 6 was prepared.

[0046] Preparation Example 2-7

[0047] The other conditions were the same as in Preparation Example 2-1, except that the number average molecular weight of the PEG segment of the polyethylene glycol diacrylate was 600, and finally, iodine-containing polymer 7 was prepared.

[0048] Preparation Example 2-8

[0049] The other conditions were the same as in Preparation Example 2-1, except that butyl acrylate was replaced with an equimolar amount of methyl acrylate, and finally, iodine-containing polymer 8 was prepared.

[0050] Preparation Example 2-9

[0051] The other conditions were the same as in Preparation Example 2-1, except that the polyethylene glycol diacrylate was replaced with ethylene glycol diacrylate, and finally, iodine-containing polymer 9 was prepared.

[0052] Preparation Example 2-10

[0053] The other conditions were the same as in Preparation Example 2-1, except that the polyethylene glycol diacrylate was not added, and finally, iodine-containing polymer 10 was prepared.

[0054] Preparation Example 2-11

[0055] The other conditions were the same as in Preparation Example 2-1, except that butyl acrylate was not added, and finally, iodine-containing polymer 11 was prepared.

[0056] Example 1

[0057] (S1) 40 parts by mass of 1,4-diiodobenzene was stirred and mixed uniformly with 800 parts by mass of liquid paraffin to obtain liquid phase A;

[0058] (S2) 30 parts by mass of the iodine-containing polymer 1 prepared in Preparation Example 2-1, 120 parts by mass of glyceryl triacetate, and 40 parts by mass of dimer acid were mixed uniformly under the condition of heating at 60°C and ultrasonic treatment at 200W and 120kHz to obtain liquid phase B;

[0059] (S3) Liquid phase A and liquid phase B were mixed uniformly under the condition of stirring at 400rpm, and vacuum degassing at 0.1MPa for 1h to obtain the angiographic agent for corpses, which was stored in a dark place.

[0060] Figure 1 is an angiographic image of the arterial arch of a human corpse that died 12h ago using the angiographic agent of Example 1. Figure 2 is an angiographic image of the arterial arch of a human corpse that died 72h ago using the angiographic agent of Example 1. As can be seen, even 72h after death, the angiographic agent of the present application still has a very good angiographic effect.

[0061] Example 2

[0062] The other conditions were the same as in Example 1, except that the iodine-containing polymer 1 prepared in Preparation Example 2-1 was replaced by the iodine-containing polymer 2 prepared in Preparation Example 2-2.

[0063] Example 3

[0064] The other conditions were the same as in Example 1, except that the iodine-containing polymer 1 prepared in Preparation Example 2-1 was replaced by the iodine-containing polymer 3 prepared in Preparation Example 2-3.

[0065] Example 4

[0066] The other conditions were the same as in Example 1, except that the iodine-containing polymer 1 prepared in Preparation Example 2-1 was replaced by the iodine-containing polymer 4 prepared in Preparation Example 2-4.

[0067] Example 5

[0068] The other conditions were the same as in Example 1, except that the iodine-containing polymer 1 prepared in Preparation Example 2-1 was replaced by the iodine-containing polymer 5 prepared in Preparation Example 2-5.

[0069] Example 6

[0070] The other conditions were the same as in Example 1, except that the iodine-containing polymer 1 prepared in Preparation Example 2-1 was replaced by the iodine-containing polymer 6 prepared in Preparation Example 2-6.

[0071] Example 7

[0072] The other conditions are the same as in Example 1, except that the iodine-containing polymer 1 prepared in Preparation Example 2-1 is replaced with the iodine-containing polymer 7 prepared in Preparation Example 2-7.

[0073] Example 8

[0074] (S1) 50 parts by mass of 1,4-diiodobenzene was stirred and mixed uniformly with 800 parts by mass of liquid paraffin to obtain liquid phase A;

[0075] (S2) 20 parts by mass of the iodine-containing polymer 1 prepared in Preparation Example 2-1, 120 parts by mass of triacetin, and 10 parts by mass of dimer acid were mixed uniformly under the condition of heating at 60°C and ultrasonic treatment at 200W and 120kHz to obtain liquid phase B;

[0076] (S3) Liquid phase A and liquid phase B were mixed uniformly under the condition of stirring at 400rpm, and vacuum degassing was performed at 0.1MPa for 1h to obtain a vascular contrast agent for cadavers, which was stored in a light-proof manner.

[0077] Example 9

[0078] (S1) 30 parts by mass of 1,4-diiodobenzene was stirred and mixed uniformly with 800 parts by mass of liquid paraffin to obtain liquid phase A;

[0079] (S2) 35 parts by mass of the iodine-containing polymer 1 prepared in Preparation Example 2-1, 120 parts by mass of triacetin, and 30 parts by mass of dimer acid were mixed uniformly under the condition of heating at 60°C and ultrasonic treatment at 200W and 120kHz to obtain liquid phase B;

[0080] (S3) Liquid phase A and liquid phase B were mixed uniformly under the condition of stirring at 400rpm, and vacuum degassing was performed at 0.1MPa for 1h to obtain a vascular contrast agent for cadavers, which was stored in a light-proof manner.

[0081] Comparative Example 1

[0082] The other conditions are the same as in Example 1, except that the iodine-containing polymer 1 prepared in Preparation Example 2-1 is replaced with the iodine-containing polymer 8 prepared in Preparation Example 2-8.

[0083] Comparative Example 2

[0084] The other conditions are the same as in Example 1, except that the iodine-containing polymer 1 prepared in Preparation Example 2-1 is replaced with the iodine-containing polymer 9 prepared in Preparation Example 2-9.

[0085] Comparative Example 3

[0086] The other conditions are the same as in Example 1, except that the iodine-containing polymer 1 prepared in Preparation Example 2-1 is replaced with the iodine-containing polymer 10 prepared in Preparation Example 2-10.

[0087] Comparative Example 4

[0088] Other conditions are the same as in Example 1, except that the iodine-containing polymer 1 prepared in Preparation Example 2-1 is replaced by the iodine-containing polymer 11 prepared in Preparation Example 2-11.

[0089] Comparative Example 5

[0090] 70 parts by mass of 1,4-diiodobenzene, 120 parts by mass of glyceryl triacetate, 40 parts by mass of dimer acid, and 800 parts by mass of liquid paraffin are mixed uniformly and stored in the dark. That is, compared with Example 1, no iodine-containing polymer is added, and 1,4-diiodobenzene is added instead.

[0091] Comparative Example 6

[0092] Other conditions are the same as in Example 1, except that glyceryl triacetate is replaced by Span-20 in equal mass.

[0093] Application Example

[0094] Adult rabbits are completely randomly divided into 28 groups, 4 rabbits in each group, and the angiographic agents of the above examples and comparative examples are tested on 2 rabbits in each group, one group is tested within 12 hours after death, and the other group is tested within 84 hours after 72 hours of death. The rabbits are anesthetized and sacrificed by ear marginal vein injection of 20% chloral hydrate according to body weight (3 ml / kg), and after sacrifice, the left common carotid artery is cannulated and the right common carotid artery is ligated, and the rabbits are injected with 20 mL each through the common carotid artery cannula at a flow rate of 0.2 mL / s at room temperature using a high-pressure injector. PMCT scanning is performed once before and after injection in situ (scan parameters: tube voltage 120 kV, tube current automatic, scan layer thickness 1.0 mm). The aortic arch lumen of each rabbit is selected, and 1 ROI is randomly selected in each segment, and the CT value is recorded, as shown in Table 1.

[0095] Table 1 Effect of postmortem angiographic agents on angiography of rabbits at different death times

[0096]

[0097] As can be seen from the data in Table 1, the angiographic agent provided by the present application is very suitable for postmortem examination, and has excellent angiographic effect within 12 hours of death, and even if the death time exceeds 72 hours, it also has good angiographic effect. This is due to the use of the iodine-containing polymer in the present application, which is copolymerized from (meth) acrylic C4-6 alkyl ester, polyethylene glycol diacrylate and iodine-containing monomer. Missing any one of the monomers or changing the type of monomer cannot achieve the purpose of having excellent angiographic effect for a long death time. At the same time, glyceryl triacetate also plays an important role in the angiographic agent.

Claims

1. A contrast agent for cadavers, characterized in that, The composition comprises the following components in parts by weight: 20-35 parts of an iodine-containing polymer, 30-50 parts of an iodobenzene ring compound, 90-150 parts of glyceryl triacetate, 30-40 parts of dimer acid, and 600-800 parts of liquid paraffin; wherein the iodine-containing polymer is obtained by copolymerization of alkyl acrylate, polyethylene glycol diacrylate, and an iodine-containing monomer; the alkyl carbon chain length in the alkyl acrylate is 4-6; the iodine-containing monomer is (meth)acrylate iodobenzene; the (meth)acrylate iodobenzene is selected from at least one of (meth)acrylate 3,4,5-triiodobenzene, (meth)acrylate 3-iodobenzene, (meth)acrylate 2-iodobenzene, and (meth)acrylate 3,5-diiodobenzene; and the iodobenzene ring compound is selected from at least one of 1,2-diiodobenzene, 1,3-diiodobenzene, and 1,4-diiodobenzene.

2. The cadaveric contrast agent according to claim 1, characterized in that... The molar ratio of alkyl acrylate, polyethylene glycol diacrylate and iodine-containing monomer is 6-10:0.5-0.8:3-5.

3. The cadaveric contrast agent according to claim 1, characterized in that, The (meth)acrylate iodobenzoyl is prepared by esterification of (meth)acrylic acid and iodobenzyl alcohol, wherein the iodobenzyl alcohol is selected from at least one of 3,4,5-triiodobenzyl alcohol, 3-iodobenzyl alcohol, 2-iodobenzyl alcohol, and 3,5-diiodobenzyl alcohol.

4. The cadaveric contrast agent according to claim 1, characterized in that, The alkyl acrylate is selected from at least one of butyl acrylate, pentyl acrylate, and hexyl acrylate; the number average molecular weight of the PEG segment in the polyethylene glycol diacrylate is 200-400 g / mol.

5. The cadaveric contrast agent according to claim 1, characterized in that, The iodine-containing polymer is prepared by a method including the following steps: under an inert atmosphere, alkyl acrylate, polyethylene glycol diacrylate and iodine-containing monomer are added to an organic solvent, and an initiator is slowly added while heating. The temperature is raised to 70-80℃ and the reaction is carried out for 6-10 hours. After the reaction is completed, the reaction solution is poured into methanol, the polymer precipitates, and the polymer is washed and dried to obtain the iodine-containing polymer.

6. The cadaveric contrast agent according to claim 1, characterized in that, Dimeric acid has an acid value of 180-210 mg KOH / g and a viscosity of 4000-7000 mPa·s at 25℃; liquid paraffin has a viscosity of 10-40 mPa·s at 25℃.

7. The method for preparing the cadaveric contrast agent according to any one of claims 1-6, characterized in that, Includes the following steps: (S1) Accurately weigh each material, and stir and mix the iodobenzene ring compound with liquid paraffin to obtain liquid phase A; (S2) Under heating conditions of 50-60℃, the iodine-containing polymer, glyceryl triacetate and dimer acid are ultrasonically mixed evenly to obtain liquid phase B; (S3) Liquid phase A and liquid phase B are mixed evenly under stirring at 300-600 rpm, and degassed under vacuum to obtain the cadaver contrast agent, which is then stored in a sealed container away from light.

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