Pharmaceutical composition, preparation as well as preparation method and application of pharmaceutical composition

By combining ginkgolide B with dextroborneol, a variety of drug formulations were prepared, which solved the problems of poor efficacy and large side effects of neuroprotective agents, and achieved effective treatment and cost control for ischemic stroke.

CN120919111APending Publication Date: 2025-11-11JIANGSU KANION PHARMA CO LTD
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Patent Information

Application Number
CN202510588698.1
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Priority Date
2024-05-11
Filing Date
2025-05-08
Publication Date
2025-11-11

AI Technical Summary

Technical Problem

The clinical trial translation results of existing neuroprotective agents in ischemic stroke are poor, the efficacy of single-target agents is not good, and dextroborneol has significant side effects, while ginkgolide B is expensive, resulting in high clinical usage costs.

Method used

Ginkgolide B, when used in combination with dextromethorphanol, inhibits inflammation and stimulates inhibitory GABAAR receptors by regulating the NF-κB and p38 signaling pathways. It can be prepared into various drug formulations, including tablets and capsules, to exert a synergistic effect.

Benefits of technology

It significantly improves neurological function in ischemic stroke, reduces the dosage of dextromethorphan and ginkgolide B, lowers costs, reduces side effects, and enables large-scale industrial production.

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Abstract

The invention provides a pharmaceutical composition, a preparation as well as a preparation method and application of the pharmaceutical composition. The pharmaceutical composition comprises bilobalide B and dextroborneol, the weight ratio of the bilobalide B to the dextroborneol is (0.02 to 50): 1. In the pharmaceutical composition disclosed by the invention, bilobalide B and dextroborneol can play a synergistic effect, and the pharmaceutical composition has an excellent effect, small side effects and an excellent clinical application prospect when being used for treating cerebral arterial thrombosis; the traditional Chinese medicine composition is novel in formula, simple in component, clear in action mechanism, remarkable in curative effect, not prone to tolerance generation and capable of achieving large-scale industrial production.
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