A tightening soothing composition containing oxyresveratrol and application thereof

Abstract

The present application relates to a kind of oxyresveratrol-containing firming soothing composition and application, belong to the field of cosmetics.The present application first provides a kind of oxyresveratrol-containing firming soothing composition, including mass ratio (0.05-2) :(1-5) :(0.01-2) :(0.01-2) oxyresveratrol particle, high mountain fire-moss extract, yarrow extract, artemisia capillaris extract;Wherein oxyresveratrol particle is with lignin as carrier and is loaded oxyresveratrol, which greatly improves the light stability of oxyresveratrol.In addition, by the synergistic effect of the above four components, the composition can meet the firming anti-aging effect from the promotion of collagen and elastin, inhibition of decomposition, accelerate cell renewal and so on.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of cosmetics, in particular to a tightening and soothing composition containing oxidized trans-resveratrol and application thereof. BACKGROUND

[0002] Oxidized trans-resveratrol is a natural active ingredient extracted from plants or obtained by oxidation of trans-resveratrol. As a derivative of trans-resveratrol, it has stronger biological activity and thus has great application potential in cosmetics and functional foods. However, the phenolic hydroxyl group and conjugated system in the molecular structure of oxidized trans-resveratrol make it extremely sensitive to environmental factors such as light, heat and oxygen. Under light, it is prone to isomerization, degradation and oxidation, resulting in a significant decrease in activity and a darkening of color (such as yellowing and browning), which not only affects the appearance of the product, but also seriously limits its formulation application and shelf life.

[0003] In the prior art, cyclodextrin or liposome is often used to encapsulate it to improve its light stability, but there are defects such as low encapsulation efficiency and questionable safety of synthetic high molecular polymers. Lignin is a natural high molecular polymer with wide sources and low price, which is biodegradable. The three-dimensional network structure of lignin is rich in functional groups such as phenolic hydroxyl groups and ether bonds, and has good ultraviolet absorption capacity and antioxidant properties, making it an ideal bio-based carrier material. Currently, there is no report on the use of lignin to load oxidized trans-resveratrol to improve its light stability. Secondly, it is also of important application value to provide a composition containing oxidized trans-resveratrol with light stability for application in cosmetics. SUMMARY

[0004] The present application aims to overcome the shortcomings of the prior art and provide a tightening and soothing composition containing oxidized trans-resveratrol and application thereof.

[0005] To achieve the above-mentioned purpose, the technical solution adopted by the present application is as follows:

[0006] In a first aspect, the present application provides a tightening and soothing composition containing oxidized trans-resveratrol, which comprises oxidized trans-resveratrol particles, high mountain fireweed extract, yarrow extract and artemisia capillaris extract in a mass ratio of (0.05-2):(1-5):(0.01-2):(0.01-2); the oxidized trans-resveratrol particles are obtained by loading oxidized trans-resveratrol on lignin as a carrier.

[0007] Oxidized trans-resveratrol can reduce the content of AGEs induced by glycosylation, increase the expression of collagen, reduce the expression of p16INK4a, maintain the cell proliferation ability, and improve the skin function, enhance the epidermal thickness and promote the differentiation of keratinocytes.

[0008] The rosmarinus acid A in the high mountain fireweed extract can inhibit the expression of matrix metalloproteinase MMP-1, and reduce the degradation of collagen and elastin.

[0009] The extract of yarrow can inhibit elastase, and has the function of promoting the proliferation of epidermal keratinocytes, restoring the elasticity of skin fibrous tissue, balancing and accelerating the metabolism of skin cells.

[0010] The extract of artemisia capillaris can inhibit hyaluronidase to protect hyaluronic acid from decomposition, increase the moisture content of the skin, and reduce wrinkles and skin laxity.

[0011] The present application adopts lignin to load oxidized white vitis vinifera to obtain oxidized white vitis vinifera particles, greatly improves the light stability of oxidized white vitis vinifera, and reasonably compounds the oxidized white vitis vinifera particles with high mountain fireweed extract, yarrow extract and artemisia capillaris extract, the four components can synergistically promote the generation of collagen and elastin, improve the skin elasticity, skin firmness, trans-epidermal water loss rate and facial redness of the subject, and can meet the effect of firming and anti-aging from multiple dimensions.

[0012] Further, the firming and soothing composition containing oxidized white vitis vinifera includes oxidized white vitis vinifera particles, high mountain fireweed extract, yarrow extract and artemisia capillaris extract with a mass ratio of (0.05-1):(1-3.5):(0.01-1):(0.01-1).

[0013] Preferably, the firming and soothing composition containing oxidized white vitis vinifera includes oxidized white vitis vinifera particles, high mountain fireweed extract, yarrow extract and artemisia capillaris extract with a mass ratio of (0.1-1):(2-3.5):(0.2-1):(0.2-1).

[0014] Preferably, the firming and soothing composition containing oxidized white vitis vinifera includes oxidized white vitis vinifera particles, high mountain fireweed extract, yarrow extract and artemisia capillaris extract with a mass ratio of 0.1:2:0.2:0.2.

[0015] Further, the preparation method of the oxidized white vitis vinifera particles includes the following steps:

[0016] S1. Take oxidized white vitis vinifera and lignin with a mass ratio of 1:2-5, prepare a solution with a concentration of 0.5-1mg / mL with ethanol as the solvent, stir for 1-2h, remove the insoluble matter, and obtain a solution system;

[0017] S2. While stirring, add deionized water equivalent to 7-9 times the weight of the solution system drop by drop, continue to stir for 5-10min, and obtain the oxidized white vitis vinifera particles.

[0018] Preferably, the mass ratio of oxidized resveratrol and lignin in step S1 is 1:3.5-5, further preferably 1:3.5.

[0019] Preferably, the concentration of the prepared solution in step S1 is 1 mg / mL, and stirring is performed for 1 h.

[0020] Preferably, in step S2, deionized water equivalent to 8 times the weight of the solution system is added dropwise while stirring, and stirring is continued for 8 min to obtain oxidized resveratrol particles.

[0021] In a second aspect, the present application provides use of the above-mentioned any one of the tight and soothing compositions containing oxidized resveratrol in the preparation of a tight anti-aging cosmetic.

[0022] Further, the mass ratio of the tight and soothing composition containing oxidized resveratrol in the cosmetic is 1-5%.

[0023] Preferably, the mass ratio of the tight and soothing composition containing oxidized resveratrol in the cosmetic is 3%.

[0024] Further, the cosmetic is a cosmetic water, emulsion, cream, mask, serum or spray.

[0025] Preferably, the cosmetic is an emulsion.

[0026] In a third aspect, the present application provides an emulsion, comprising the following weight percentage raw materials: 1-5% of the above-mentioned any one of the tight and soothing compositions containing oxidized resveratrol, 3-4% of a humectant, 0.1-0.5% of a thickening agent, 0.5-2.5% of an emulsifier, 4.5-6.5% of oil, 0.5-3% of a preservative, 0.1-0.5% of a pH adjuster, and the balance being water.

[0027] Further, the emulsion comprises the following weight percentage raw materials: 1-5% of the above-mentioned any one of the tight and soothing compositions containing oxidized resveratrol, 3.5% of a humectant, 0.2% of a thickening agent, 2.5% of an emulsifier, 6.5% of oil, 3% of a preservative, 0.2% of a pH adjuster, and the balance being water.

[0028] Further, the humectant includes but is not limited to any one or more of glycerin, butylene glycol, pentylene glycol, sorbitol, and methyl gluceth-10 / 20.

[0029] Further, the thickening agent includes but is not limited to any one or more of carbomer 980, xanthan gum, and hydroxyethyl cellulose.

[0030] Further, the emulsifier includes but is not limited to any one or more of C14-22 alkyl alcohol / C12-20 alkyl glucoside and cetyl stearyl alcohol.

[0031] Further, the oil includes but is not limited to any one or more of caprylic capric triglyceride, dimethicone, squalane.

[0032] Further, the preservative includes but is not limited to any one or more of 1,2-hexanediol, p-hydroxyacetophenone, 1,3-propanediol, sorbic acid.

[0033] Further, the pH regulator includes but is not limited to any one or more of arginine, sodium hydroxide, succinic acid.

[0034] Preferably, the humectant is glycerin, the thickening agent is carbomer 980, the emulsifier is C14-22 alkyl alcohol / C12-20 alkyl glucoside and cetearyl alcohol, the oil is caprylic capric triglyceride and dimethicone, the preservative is 1,2-hexanediol, p-hydroxyacetophenone and 1,3-propanediol, and the pH regulator is arginine.

[0035] Further, the preparation process of the emulsion includes the following steps:

[0036] 1) Mix the components of phase A with water and stir, heat to 75-85℃, then homogenize at a speed of 1000-1500 rpm for 4-6 min, and keep warm after homogenization for standby, to obtain the water phase; the phase A is the humectant and the thickening agent;

[0037] 2) Mix the components of phase B, heat to 75-85℃, then homogenize at a speed of 1000-1500 rpm for 4-6 min, and keep warm after homogenization for standby, to obtain the oil phase; the phase B is the emulsifier and the oil;

[0038] 3) Mix the components of phase C and melt by heating to 55-65℃; the phase C is the preservative;

[0039] 4) Warm the water phase to 75-85℃, add the oil phase at a speed of 250-400 rpm, stir and mix, then cool to 55-60℃, add the preservative at a speed of 250-400 rpm, stir and mix, then cool to below 40-45℃, add the composition described in the application, continue to stir for 5-10 min, finally add the pH regulator to adjust the pH to 5.0-6.5, stop stirring, discharge, to obtain the emulsion.

[0040] Compared with the prior art, the application has the following beneficial effects:

[0041] The tightness soothing composition containing oxyresveratrol provided by the present application comprises four components of oxyresveratrol particles, high mountain firebrush extract, milfoil extract and artemisia capillaris extract, wherein the oxyresveratrol particles are obtained by loading oxyresveratrol on lignin as a carrier, which greatly improves the light stability of oxyresveratrol; secondly, the particles are reasonably compounded with various tightness anti-aging ingredients, and the four components above play a synergistic role, so that the composition can meet the effect of tightness anti-aging from the aspects of promoting the generation of collagen and elastin, inhibiting the decomposition, accelerating cell renewal and the like. DETAILED DESCRIPTION

[0042] In order to better illustrate the purpose, technical scheme and advantages of the present application, the present application will be further described below in combination with specific examples.

[0043] Lignin was purchased from Shandong Longli Biological Technology Co., Ltd.

[0044] Oxyresveratrol was purchased from Naturalis Srl, and the product name was OXYRESVERATROL.

[0045] High mountain firebrush extract was purchased from Guangzhou Chenuo Biological Technology Co., Ltd., and the product name was high mountain firebrush extract solution.

[0046] Milfoil extract was purchased from Shaanxi Kangduo Biological Technology Co., Ltd., and the product name was milfoil extract.

[0047] Artemisia capillaris extract was purchased from Xi'an Yijun Biological Technology Co., Ltd., and the product name was artemisia capillaris extract.

[0048] Other materials, reagents and the like used in the examples can be obtained from commercial channels if there is no special description.

[0049] Example 1

[0050] Oxyresveratrol and lignin were taken in a mass ratio of 1:2, and a 0.5mg / mL solution was prepared using ethanol (analytical pure). After stirring and dissolving for 1h, the insoluble substances were removed by filtration to obtain a post-filtration solution system. Using a magnetic stirrer for high-speed stirring, 7 times the weight of deionized water of the post-filtration solution system was added dropwise, and stirring was continued for 5min to obtain a suspension of lignin particles loaded with oxyresveratrol stably dispersed in the aqueous phase, which was hereinafter referred to as "oxyresveratrol particles" for short.

[0051] Example 2

[0052] Oxidized white resveratrol and lignin were taken in a mass ratio of 1:3.5, and a solution of 1 mg / mL was prepared using ethanol (analytical pure), stirred and dissolved for 1 h, and insoluble substances were removed by filtration to obtain a post-filtration solution system; using a magnetic stirrer for high-speed stirring, 8 times the weight of deionized water of the post-filtration solution system was added dropwise, and stirring was continued for 8 min to obtain oxidized white resveratrol particles.

[0053] Example 3

[0054] Oxidized white resveratrol and lignin were taken in a mass ratio of 1:5, and a solution of 1 mg / mL was prepared using ethanol (analytical pure), stirred and dissolved for 2 h, and insoluble substances were removed by filtration to obtain a post-filtration solution system; using a magnetic stirrer for high-speed stirring, 9 times the weight of deionized water of the post-filtration solution system was added dropwise, and stirring was continued for 10 min to obtain oxidized white resveratrol particles.

[0055] Comparative Example 1

[0056] Oxidized white resveratrol and lignin were taken in a mass ratio of 1:6, and a solution of 1 mg / mL was prepared using ethanol (analytical pure), stirred and dissolved for 1 h, and insoluble substances were removed by filtration to obtain a post-filtration solution system; using a magnetic stirrer for high-speed stirring, 8 times the weight of deionized water of the post-filtration solution system was added dropwise, and stirring was continued for 8 min to obtain oxidized white resveratrol particles.

[0057] Comparative Example 2

[0058] Oxidized white resveratrol and lignin were taken in a mass ratio of 1:1, and a solution of 1 mg / mL was prepared using ethanol (analytical pure), stirred and dissolved for 1 h, and insoluble substances were removed by filtration to obtain a post-filtration solution system; using a magnetic stirrer for high-speed stirring, 8 times the weight of deionized water of the post-filtration solution system was added dropwise, and stirring was continued for 8 min to obtain oxidized white resveratrol particles.

[0059] Comparative Example 3

[0060] Oxidized white resveratrol and lignin were taken in a mass ratio of 1:3.5, and a solution of 2 mg / mL was prepared using ethanol (analytical pure), stirred and dissolved for 1 h, and insoluble substances were removed by filtration to obtain a post-filtration solution system; using a magnetic stirrer for high-speed stirring, 8 times the weight of deionized water of the post-filtration solution system was added dropwise, and stirring was continued for 8 min to obtain oxidized white resveratrol particles.

[0061] Comparative Example 4

[0062] The oxidized white resveratrol and lignin were taken in a mass ratio of 1:3.5, 1 mg / mL solution was prepared using acetone (analytical pure), stirred and dissolved for 1 h, and insoluble substances were removed by filtration to obtain a filtered solution system; using a magnetic stirrer for high-speed stirring, 8 times the weight of deionized water of the filtered solution system was added dropwise, and stirring was continued for 8 min to obtain the oxidized white resveratrol particles.

[0063] Test Example 1: Light stability test of oxidized white resveratrol particles

[0064] The light stability of the oxidized white resveratrol particles prepared in Comparative Examples 1-3 and Comparative Examples 1-4 and untreated oxidized white resveratrol was compared, and the determination method was as follows:

[0065] The untreated oxidized white resveratrol powder, the oxidized white resveratrol particles prepared in Examples 1-3 and Comparative Examples 1-4 were placed under 365 nm light for 2 h, the content of oxidized white resveratrol in different samples before and after light irradiation was tested using HPLC, and the degradation rate of oxidized white resveratrol was calculated, % degradation of oxidized white resveratrol = (content of oxidized white resveratrol before light irradiation - content of oxidized white resveratrol after light irradiation) / content of oxidized white resveratrol before light irradiation * 100%.

[0066] Test results:

[0067] The test data is shown in Table 1, the degradation rate of oxidized white resveratrol of Examples 1-3 relative to untreated oxidized white resveratrol powder was reduced by 86.82%-91.83%, indicating that lignin-loaded oxidized white resveratrol can significantly improve the light stability of oxidized white resveratrol. Further, the conditions in the preparation method of the oxidized white resveratrol particles were also screened, specifically, Comparative Example 1-2 and Example 2 differ in the mass ratio of oxidized white resveratrol to lignin, Comparative Example 3 differs in the concentration of the prepared solution, and Comparative Example 4 differs in the solvent used. Comparing the test data of Example 2 and Comparative Examples 1-4: in the preparation of oxidized white resveratrol particles, using oxidized white resveratrol and lignin in a specific mass ratio range as raw materials, dissolving and preparing a solution in a specific concentration range using ethanol can greatly reduce the degradation rate of oxidized white resveratrol, which may be related to the loading effect of lignin and the stability of the particles. The results show that the lignin-loaded oxidized white resveratrol particles prepared by the preparation method provided in the examples can significantly improve the light stability of oxidized white resveratrol, and the oxidized white resveratrol particles prepared in Example 2 have the best effect, so the particles prepared in this example are selected for subsequent preparation of compositions.

[0068] Table 1: Degradation rate of oxidized white resveratrol particles

[0069]

[0070]

[0071] Application Examples 1-4 and Comparative Application Examples 1-6

[0072] (1) The composition of each of Application Examples 1-4 and Comparative Application Examples 1-6 was prepared using the oxidized white resveratrol particles prepared in Example 2 according to the formulation in Table 2.

[0073] Table 2: Components and amounts of each component in the composition

[0074]

[0075]

[0076] Note: "-" represents no addition; and the total mass of the composition in each application example is the same.

[0077] (2) The soothing repair product was prepared using the composition of each of Application Examples 1-4 and Comparative Application Examples 1-6 according to the composition in Table 3 to obtain the emulsion corresponding to each of Application Examples 1-4 and Comparative Application Examples 1-6, respectively. The preparation process of the emulsion specifically included the following steps:

[0078] 1) Pretreatment of the composition of each of Application Examples 1-4 and Comparative Application Examples 1-6: First, the corresponding mass of each component was weighed according to the formulation in Table 2 (the total mass of the composition in each application example was the same); if there were oxidized white resveratrol particles in the formulation, the oxidized white resveratrol particles were first dispersed in water 10 times the mass of the composition, and then the other components in the composition were mixed and stirred to dissolve; if there were no oxidized white resveratrol particles in the formulation, the components in the composition were mixed and then added to water 10 times the mass of the composition to stir and dissolve, to obtain a pretreated composition solution;

[0079] 2) The components of phase A were mixed with an appropriate amount of water, heated to 80°C, and then homogenized at a speed of 1200 rpm for 5 min. After homogenization, the water phase was prepared and kept warm for standby;

[0080] 3) The components of phase B were mixed, heated to 80°C, and then homogenized at a speed of 1200 rpm for 5 min. After homogenization, the oil phase was prepared and kept warm for standby;

[0081] 4) The components of phase C were mixed and melted at 60°C to obtain the preservative;

[0082] 5) The water phase was warmed to 80°C, and the oil phase was added at a speed of 300 rpm while stirring. Then, the temperature was lowered to 60°C, and the preservative was added at a speed of 300 rpm while stirring. Subsequently, the temperature was lowered to below 45°C, and the pretreated composition solution was added while stirring for 5 min. Finally, arginine was added to adjust the pH to 5.0-6.5, and the stirring was stopped. The emulsion was discharged.

[0083] Table 3 Composition of ingredients in soothing repair products

[0084]

[0085]

[0086] Test Example 2 Determination of the effect of the compositions on collagen I and elastin content

[0087] The compositions of Application Examples 1-4 and Comparative Application Examples 1-6 were used as test samples to determine their effect on collagen I and elastin content. The method was as follows:

[0088] Human dermal fibroblasts HSF were inoculated in 96-well cell culture plates at a density of 2000 cells / well, 100 μL of DMEM + 10% fetal bovine serum (FBS) + 1% penicillin / streptomycin culture solution was added to each well, and the cells were incubated for 24 h. The supernatant was discarded, and the cells were divided into a blank group and an experimental group. The blank group was added with 100 μL of DMEM culture medium. The experimental group was added with 100 μL of culture medium containing 0.1% of the corresponding test sample (the sample was dissolved with DMSO and then diluted with DMEM culture medium). After 24 h of incubation, the cells in each group were collected, the culture medium was discarded, and the cells were washed twice with PBS. 1 mL of TRIzol lysis solution was added, the cells were scraped, transferred to an EP tube, and stored at -80°C for later use. The human collagen I (Col I) ELISA kit (enzyme-linked biotechnology, item number ml057630) and the human elastin ELISA kit (enzyme-linked biotechnology, ml038411) were used to detect the content of collagen I and elastin in the HSF cells, respectively. The results were expressed as the protein content promotion rate, which was calculated as follows: protein content promotion rate = |(protein content of the experimental group - protein content of the blank group) / protein content of the blank group| x 100%. 实验组 Protein content 空白组 . 空白组

[0089] Test results:

[0090] ​The results are shown in Table 4. The type I collagen promotion rate of application examples 1-4 reached 188.29%-218.14%, and the elastin promotion rate reached 115.04%-133.67%, indicating that the composition provided by the application can significantly promote the synthesis of type I collagen and elastin. Comparing application example 2 with comparative application examples 1-3, it can be seen that the type I collagen promotion rate and the elastin promotion rate of the composition lacking one or two components are significantly reduced. Comparing application example 2 with comparative application examples 4-5, it can be seen that replacing the oxidized white resveratrol in the composition with white resveratrol or replacing the high mountain fireweed extract with scute extract, wherein white resveratrol is a natural polyphenol and a powerful antioxidant and anti-inflammatory compound, and in addition, white resveratrol can enhance collagen synthesis and has a certain firming effect; and scute extract has the effects of anti-aging, firming and soothing the skin, but the composition provided by comparative application examples 4-5 also has a significantly lower type I collagen promotion rate and elastin promotion rate than the composition provided by application example 2 of the application. In combination with the above results, it can be seen that the combination of oxidized white resveratrol particles, high mountain fireweed extract, yarrow extract and artemisia capillaris extract in the composition of the application can produce a synergistic effect. Comparing comparative application example 6 with application examples 1-4, it can be seen that the ratio of different components also has a significant effect on the composition in increasing the content of type I collagen and elastin.

[0091] Table 4 Type I collagen and elastin content promotion rate results

[0092] Group Collagen I promotion rate (%) Elastin promotion rate (%) Example 1 195.38 115.04 Example 2 218.14 133.67 Example 3 207.65 128.25 Example 4 188.29 119.89 Comparative Example 1 85.73 49.16 Comparative Example 2 76.97 35.52 Comparative Example 3 101.82 58.30 Comparative Example 4 93.58 52.37 Comparative Example 5 77.21 30.93 Comparative Example 6 116.46 74.21

[0093] Test example 3 skin firming, soothing and repairing effect test

[0094] The emulsions prepared using application examples 1-4 and comparative application examples 1-6 were used as test samples to test the skin firming, soothing and repairing effects. The method is as follows:

[0095] (1) 100 volunteers aged 18-45 were selected, and the subjects were randomly divided into 10 groups, 10 people in each group. In the test, the emulsions of application examples 1-4 and comparative application examples 1-6 of the application were randomly used by each group, once a day in the morning and evening, and the use method was as follows: after cleansing and moisturizing, 1g of the sample was evenly applied to the whole face, and gently massaged until completely absorbed. On the 0th and 7th days, the subjects returned to test the indicators.

[0096] (2) On the 0th and 7th days of the return visit, the subjects did not apply any skin care products, and after cleansing, they sat in a constant temperature and humidity room with a temperature of 21±1℃ and a humidity of 50±10% for 30min. A skin elasticity tester, a transdermal water loss probe TM Hex (Courage+Khazaka) and a moisture probe The initial skin elasticity coefficient R2 value, skin firmness F4 value, TEWL value of the test subject after cleansing, and facial photography using Visia-7, image analysis of the derived red area picture, and initial a* value were determined by CM 825 (Courage + Khazaka);

[0097] (3) The improvement of each index was analyzed, and the data were averaged. The improvement was calculated as follows:

[0098] Improvement rate (%) = | (X 使用后 -X 使用前 ) / X 使用前 x 100% |;

[0099] In the formula:

[0100] X 使用前 is the data of each index of the test subject before using the product;

[0101] X 使用后 is the data of each index of the test subject before using the product.

[0102] Test results:

[0103] The results are shown in Table 5. From the R2 value improvement rate, F4 value improvement rate, TEWL value improvement rate, and a value improvement rate in the application example, it can be seen that the emulsion prepared from the composition provided by the application has a significant effect of improving skin elasticity, tightening skin, moisturizing, and soothing redness. The test results of the comparative application and the application comparative example show that the emulsion prepared from the composition provided by the application has a better effect in improving skin elasticity, tightening, moisturizing, and soothing, indicating that the components of the composition with a specific ratio provided by the application have a synergistic effect, which can synergistically improve the effect of the composition in tightening skin, soothing, and repairing.

[0104] Table 5. Test results of skin tightening, soothing, and repairing effect

[0105] Group R2 value improvement rate (%) F4 value improvement rate (%) TEWL value improvement rate (%) a value improvement rate (%) Example 1 11.9 22.5 11.6 7.2 Example 2 13.6 25.8 13.5 7.9 Example 3 12.9 24.7 12.8 6.8 Example 4 11.2 21.4 12.1 7.1 Comparative Example 1 4.4 9.9 8.3 4.0 Comparative Example 2 3.7 8.6 6.8 3.8 Comparative Example 3 5.9 11.3 6.4 4.4 Comparative Example 4 5.1 10.5 7.2 3.6 Comparative Example 5 3.3 7.7 8.0 4.3 Comparative Example 6 6.8 13.9 9.6 4.7

[0106] Finally, it should be noted that the above examples are only used to illustrate the technical solutions of the present application and do not limit the protection scope of the present application. Although the present application has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solutions of the present application can be modified or replaced by equivalents without departing from the essence and scope of the technical solutions of the present application.

Claims

1. A firming and soothing composition containing oxidized resveratrol, characterized in that, The mixture includes oxidized resveratrol granules, edelweiss extract, yarrow extract, and artemisia extract in a mass ratio of (0.05-2):(1-5):(0.01-2):(0.01-2); the oxidized resveratrol granules are obtained by loading oxidized resveratrol onto lignin, and the preparation method includes the following steps: S1. Take resveratrol oxide and lignin in a mass ratio of 1:2-5, use ethanol as solvent, prepare a solution with a concentration of 0.5-1 mg / mL, stir for 1-2 h, remove insoluble matter, and obtain the solution system; S2. While stirring, add deionized water dropwise, equivalent to 7-9 times the weight of the solution system, and continue stirring for 5-10 minutes to obtain oxidized resveratrol granules.

2. The firming and soothing composition containing oxidized resveratrol as described in claim 1, characterized in that, It includes oxidized resveratrol granules, edelweiss extract, yarrow extract, and artemisia extract in a mass ratio of (0.05-1):(1-3.5):(0.01-1):(0.01-1).

3. The firming and soothing composition containing oxidized resveratrol as described in claim 1, characterized in that, It includes oxidized resveratrol granules, edelweiss extract, yarrow extract, and artemisia extract in a mass ratio of (0.1-1):(2-3.5):(0.2-1):(0.2-1).

4. The firming and soothing composition containing oxidized resveratrol as described in claim 1, characterized in that, In step S1, the mass ratio of oxidized resveratrol to lignin is 1:2-3.

5.

5. The firming and soothing composition containing oxidized resveratrol as described in claim 1, characterized in that, In step S1, the concentration of the prepared solution is 1 mg / mL.

6. The use of the firming and soothing composition containing oxidized resveratrol according to any one of claims 1-5 in the preparation of firming and anti-aging cosmetics.

7. The application as described in claim 6, characterized in that, The firming and soothing composition containing oxidized resveratrol accounts for 1-5% of the total mass of the cosmetic.

8. The application as described in claim 6, characterized in that, The cosmetics mentioned are toners, lotions, creams, masks, serums, or sprays.

9. An emulsion, characterized in that, The composition comprises the following ingredients by weight percentage: 1-5% of the firming and soothing composition containing oxidized resveratrol as described in any one of claims 1-5, 3-4% of the moisturizer, 0.1-0.5% of the thickener, 0.5-2.5% of the emulsifier, 4.5-6.5% of the oil, 0.5-3% of the preservative, 0.1-0.5% of the pH adjuster, and the balance being water.

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