A lip gel composition for reducing wrinkles and moisturizing, and its preparation method.

Abstract

This invention relates to a lip gel composition for reducing wrinkles and moisturizing, and its preparation method. The lip gel composition, by weight percentage, comprises: 0.5-1.5% dipalmitoyl hydroxyproline, 0.05-0.1% hybrid rose extract, 0.02-0.05% hyaluronic acid microspheres, 15-20% castor seed oil, 0.05-0.1% sunflower seed oil, 0.0005-0.001% β-carotene, 35-41% caprylic / capric triglycerides, and 32-50% octyl-dodecyl alcohol. The hyaluronic acid microspheres are composed of hyaluronic acid encapsulated in castor seed oil. The preparation employs a staged low-temperature mixing process: first, an oil phase carrier is formed at 60-80℃; then, a collagen activator is added for dispersion; and finally, the heat-sensitive active ingredients are integrated at ≤40℃. This solution breaks through the limitations of traditional lip products where efficacy and skin feel cannot be achieved simultaneously. Tests have shown that after 30 days of use, lip lines are reduced by more than 40%, and hydration is increased by more than 60% after 4 hours. Moreover, no synthetic preservatives or synthetic pigments are added throughout the entire process.

Description

Technical Field

[0001] This invention relates to the field of cosmetic technology, and in particular to a lip gel composition for reducing wrinkles and moisturizing, and its preparation method. Background Technology

[0002] As a transitional tissue between oral mucosa and normal skin, the skin of the lips has a complex and unique structure. Because the skin of the lips lacks sebaceous glands, sweat glands, and hair follicles, it cannot regulate transepidermal water loss, skin water retention, or the secretion of sebum to form a sebum film like normal skin. Lacking a natural protective film, the moisture content of the lips fluctuates dramatically, with water evaporation occurring six times faster than in other parts of the face. Changes in the moisture level of the external environment cause rapid evaporation of moisture from the lips, easily leading to dryness, cracking, or severe peeling. Furthermore, the skin of the lips is only one-third the thickness of the skin on the body. While the average facial skin contains 16 layers of keratinocytes, the lip skin has only 3, making it one of the most sensitive and delicate areas of the face. With age, the skin loses collagen, resulting in insufficient support for the lips, causing them to gradually lose elasticity, become less plump, and develop lip lines, making the lips appear less refined. Similarly, the skin on the lips is always exposed and is very susceptible to environmental damage, such as dryness, cold, and ultraviolet rays.

[0003] The increased mentions of lip gels and similar products reflect a growing interest in lip care, indicating that consumers are paying more attention to the health and fullness of their lips. Consumers believe that plump lips make them look younger. Meanwhile, 90.7% of consumers reported dry, chapped lips as their most prominent problem, and over half reported noticeable lip lines and dull, lackluster lip color. This suggests that current consumer satisfaction with their lip condition is relatively low, and consumers are increasingly seeking a fuller, more glossy "glass lip" effect with fewer dry lines.

[0004] In short, unlike other parts of the body, the lips, with their low moisture content and thinner stratum corneum due to factors such as age and environment, are more prone to dryness, lip lines, and even cracking and damage. As living standards improve, people are paying increasing attention to their lip health; therefore, the efficacy of lip products has become a key focus.

[0005] Most existing lip cosmetics primarily use oils alone for sealing or add high-molecular-weight moisturizers for immediate hydration, resulting in a temporary plumpness and shine on the lips. They also use synthetic pigments to physically fill in lip lines, providing color coverage. However, the underlying dryness and dullness of the lips remain, failing to fundamentally solve the problems of dry, dull lips and deepened lip lines. Some gel-type lip products, in an effort to form a protective oil film, excessively increase the oil content, resulting in a noticeable "sticky" feeling upon application, which is detrimental to the lips' recovery to a healthy state. If the lip gel has low viscosity and high fluidity, it will not stay on the lips, resulting in poor moisturizing effects; conversely, high viscosity and low fluidity will lead to uneven application and affect the user experience. Therefore, high-molecular-weight substances are needed for thickening, making the manufacturing process more complicated. Furthermore, some products may contain irritating ingredients such as preservatives and synthetic pigments, which can burden the lip skin and worsen lip problems. Lip products with a high concentration of oils can significantly enhance the moisturizing effect on the lips, but they feel sticky and heavy, affecting the consumer experience. On the other hand, lip products that aim for a refreshing texture may not provide long-lasting hydration due to insufficient oil content.

[0006] Therefore, it is particularly important to develop a lip care product that is free of preservatives and synthetic pigments, can effectively reduce lip lines, increase lip skin moisture, and has a non-sticky feel. Summary of the Invention

[0007] In view of the shortcomings of the existing technology, the purpose of this invention is to provide a lip gel composition that reduces lip lines and moisturizes the lips, and a method for preparing the same. The lip gel composition and its preparation method are preservative-free, contain natural pigments, and can reduce lip lines, brighten the lips, and are refreshing and non-sticky.

[0008] The above-mentioned objective of this invention is achieved through the following technical solutions:

[0009] A lip gel composition for reducing wrinkles and moisturizing, comprising, by weight percentage: 0.5-1.5% dipalmitoyl hydroxyproline, 0.05-0.1% hybrid rose extract, 0.02-0.05% hyaluronic acid microspheres, 15-20% castor seed oil, 0.05-0.1% sunflower seed oil, 0.0005-0.001% β-carotene, 32-41% caprylic / capric triglycerides, and 32-50% octyl-dodecyl alcohol, wherein the hyaluronic acid microspheres are composed of hyaluronic acid encapsulated in castor seed oil.

[0010] As a further technical solution of the present invention: the molecular weight of the hyaluronic acid microspheres is less than 10kDa, and the mass ratio of castor oil to hyaluronic acid is (8-12):1.

[0011] As a further technical solution of the present invention: the mass ratio of dipalmitoyl hydroxyproline to the hybrid rose extract is (10-30):1.

[0012] As a further technical solution of the present invention: the mass ratio of the caprylic / capric triglyceride to the octyldodecyl alcohol is (1.0-1.3):1.

[0013] A method for preparing a lip gel composition that reduces wrinkles and moisturizes, as described above, includes the following steps:

[0014] Step 1: Mix octyl dodecanol, caprylic / capric triglycerides, castor seed oil, sunflower seed oil and β-carotene at 1800-2300 rpm for 45 minutes at 60-80℃ and 1-2 bar pressure to form phase A;

[0015] Step 2: Add dipalmitoyl hydroxyproline to phase A and mix at 1800-2300 rpm for 20 minutes under the same temperature and pressure to form phase B, then begin cooling.

[0016] Step 3: When the temperature drops to 20-40℃, add hybrid rose extract and microspheres containing hyaluronic acid, and mix at 1400-1800 rpm for 10 minutes under 1-2 bar pressure until completely homogenized to form a lip gel composition that reduces wrinkles and moisturizes.

[0017] As a further technical solution of the present invention: in step 3, the microspheres containing hyaluronic acid are kept at a temperature ≤30°C before mixing.

[0018] As a further technical solution of the present invention: the temperature of the entire preparation process is always ≤80℃, and no synthetic preservatives or synthetic pigments are added.

[0019] The application of the above-mentioned lip gel composition for reducing lip lines in the preparation of cosmetics for reducing lip lines showed that the lip line depth was reduced by ≥40% after 30 days of use.

[0020] The application of a lip gel composition as described above, which reduces wrinkles and moisturizes, in the preparation of long-lasting moisturizing cosmetics, resulted in an increase of ≥60% in lip moisture content after 4 hours of use.

[0021] A cosmetic composition comprising the above-described wrinkle-reducing, moisturizing lip gel composition, and a cosmetically acceptable carrier.

[0022] In summary, the present invention has at least one of the following beneficial technical effects:

[0023] 1. This invention relates to the field of cosmetic technology, specifically disclosing a lip gel composition for reducing wrinkles and moisturizing, and its preparation method. The composition comprises, in specific proportions, dipalmitoyl hydroxyproline (0.5-1.5%), hybrid rose extract (0.05-0.1%), microspheres of ultra-low molecular weight hyaluronic acid encapsulated in castor seed oil (0.02-0.05%), castor seed oil (15-20%), sunflower seed oil (0.05-0.1%), β-carotene (0.0005-0.001%), and a moisturizing agent matrix (caprylic / capric triglycerides 35-41%, octyl dodecanol 32-50%). The preparation employs a staged low-temperature mixing process: first, an oil phase carrier is formed at 60-80℃, then a collagen activator is added for dispersion, and finally, heat-sensitive active ingredients are integrated at ≤40℃. This solution breaks through the limitations of traditional lip products where efficacy and skin feel cannot be achieved simultaneously. Tests have shown that after 30 days of use, lip lines are reduced by more than 40%, and hydration is increased by more than 60% after 4 hours. Moreover, no synthetic preservatives or synthetic pigments are added throughout the entire process.

[0024] 2. The lip gel composition of the present invention comprises active ingredients and excipients. The active ingredients include dipalmitoyl hydroxyproline, hybrid rose extract, castor seed oil, sunflower seed oil, β-carotene, and emollients. Compared with the prior art, the lip cosmetic composition of the present invention can promote collagen production, effectively reduce lip lines, and brighten the lips. It does not have the stickiness of traditional lip gels and has a refreshing and breathable feel. In the production process, the temperature is always controlled below 80°C to avoid the inactivation of heat-sensitive ingredients (amino acids and plant extracts) due to high temperatures. No additional preservatives are added, reducing the burden on the lip skin.

[0025] 3. This invention adds β-carotene to the lip gel as a natural pigment to correct lip color and make the lips look fuller and plumper. Plant-derived pigments have better dispersibility and are safer than synthetic pigments.

[0026] 4. Castor seed oil and sunflower seed oil in this invention are highly safe plant-derived oils, rich in vitamins and fatty acids, and have excellent stability. This invention uses castor seed oil and sunflower seed oil as carriers (thickeners) and synergists for functional ingredients such as dipalmitoyl hydroxyproline and emollients, which can further enhance the efficacy of each functional ingredient.

[0027] 5. The combination of dipalmitoyl hydroxyproline, castor seed oil, sunflower seed oil and emollient in this invention can effectively enhance the efficacy of each functional ingredient, and has significant effects in improving lip roughness and reducing lip lines.

[0028] 6. This invention incorporates low molecular weight hyaluronic acid using oil dispersion technology to enhance the moisturizing properties of the lip gel and alleviate dryness of the lips. When caprylic / capric triglyceride and octyl dodecanol are used as emollients, hyaluronic acid, dipalmitoyl hydroxyproline, castor seed oil, and sunflower seed oil have a synergistic effect. The emollients promote the absorption of oils such as castor seed oil and active ingredients such as dipalmitoyl hydroxyproline on the lips, thereby effectively improving the condition of the lip skin without leaving a sticky feeling, thus achieving the effects of reducing wrinkles and moisturizing. Attached Figure Description

[0029] Figure 1 This is a schematic diagram illustrating the skin feel, moisturizing sensation, and improvement effect of the present invention.

[0030] Figure 2 This is a schematic diagram of the relative cell activity (Mean±SD) of each group in this invention.

[0031] Figure 3 This is a schematic diagram of the relative expression levels (Mean±SD) of the MMP2 gene in each group of the present invention. Detailed Implementation

[0032] The technical solutions in the embodiments of this application will be clearly and completely described below with reference to the embodiments of this application. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments. All other embodiments obtained by those skilled in the art based on the embodiments of this application without creative effort are within the scope of protection of this application.

[0033] In this invention, castor seed oil is sourced from Gustav Hees, dipalmitoyl hydroxyproline from Sepic, hyaluronic acid microspheres from Hyundai Bioland, and sunflower seed oil, carrot seed oil, carrot root extract, β-carotene, and tocopherol (vitamin E) from Provita SA-Germany.

[0034] The hydroxyproline in the dipalmitoyl hydroxyproline structure is an essential amino acid that plays a specific role in collagen synthesis, accounting for 10%-13% of the amino acids synthesized in collagen. Structurally, the palmitoyl group is attached to the hydroxyproline, biologically converting it into a lipid amino acid form. This allows hydroxyproline to be directly transported through the skin, significantly improving its lipid solubility and overcoming the transdermal barrier limitations. Lipases in the skin can depalmitoylate proteins, releasing active hydroxyproline for precise delivery.

[0035] Adding 0.001% dipalmitoyl hydroxyproline caused collagen fiber shrinkage by 14%, while adding only 0.0005% dipalmitoyl hydroxyproline increased the expression of type I collagen in fibroblasts by 26% and inhibited the expression of matrix metalloproteinase MMP2 by 94%, thus slowing down collagen degradation. Simultaneously, 0.0005% dipalmitoyl hydroxyproline stimulated a 61% increase in total laminin production, protecting the integrity of the dermal-epidermal junction.

[0036] Hybrid rose extract is extracted using stem cell technology. 0.1% of hybrid rose extract can downregulate COX-2 gene expression by 27%, thereby providing anti-inflammatory effects; it reduces the production of ROS in the cytoplasm under stress conditions; and it inhibits the gene expression of collagenase and elastase, thereby maintaining skin firmness and elasticity.

[0037] Hyaluronic acid (HA) is widely used in skincare. Different molecular weights of HA result in different properties and effects; lower molecular weights lead to better transdermal absorption and higher bioactivity. Hyaluronic acid microspheres are formed using oil dispersion technology. The outer layer of the microspheres is castor seed oil, which has excellent skin affinity and moisturizing properties. The interior of the microspheres contains ultra-low molecular weight HA, which has excellent transdermal absorption, moisturizing, and repairing activity. When applied to the skin, the microspheres rupture rapidly, releasing the internal low molecular weight HA, which penetrates deep into the skin to replenish moisture. The castor seed oil on the outer layer of the microspheres forms a soft oil film on the skin surface, locking in moisture and reducing water loss from the lips.

[0038] Castor seed oil contains approximately 90% ricinoleic acid (a monounsaturated fatty acid), which has high viscosity and strong adhesion, forming a dense physical barrier on the lip surface and significantly reducing moisture evaporation. Its small molecular structure can penetrate deep into the intercellular spaces of the stratum corneum, promoting tighter lipid arrangement and enhancing barrier integrity.

[0039] Sunflower seed oil is rich in linoleic acid (approximately 70%) and vitamin E. Linoleic acid is an important component of cell membrane phospholipids and can enhance the water-locking capacity of the lipid layer. Compared to castor seed oil, sunflower seed oil has a smaller molecular weight and lighter texture, forming a breathable protective film and avoiding the heavy feeling of traditional mineral lipids, making it suitable for frequent daytime use.

[0040] Both castor seed oil and sunflower seed oil are natural plant oils with molecular structures similar to human sebum. They can quickly penetrate and fill the lipid gaps on the lips, forming a protective film compatible with the skin. By forming a dynamic protective film on the lips, they balance efficacy and skin feel, instantly concealing lip lines, making them especially suitable for the needs of delicate and dry lips.

[0041] The formulation of this invention is shown in Table 1:

[0042] Table 1

[0043] Components (Standard Names) Weight percentage (%) Purpose of use Dipalmitoylhydroxyproline 0.5-1.5％ Skin conditioning agents: anti-wrinkle, firming Hybrid rose extract 0.05-0.1％ Skin conditioner: anti-inflammatory Hyaluronic acid microspheres 0.02-0.05％ Skin conditioner: moisturizing castor seed oil 15-20％ Skin conditioner: moisturizing Sunflower seed oil 0.05-0.1％ Skin conditioner: moisturizing beta-carotene 0.0005-0.001％ natural pigments Caprylic / Capric Triglyceride 35-41％ Moisturizer Octyl dodecanol 32-50％ Moisturizer

[0044] Example 1: A lip gel composition for reducing wrinkles and moisturizing, comprising, by weight percentage: 0.50% dipalmitoyl hydroxyproline, 0.05% hybrid rose extract, 0.02% hyaluronic acid microspheres, 15% castor seed oil, 0.05% sunflower seed oil, 0.0005% β-carotene, 35% caprylic / capric triglyceride, and 49.3795% octyl dodecanol, wherein the hyaluronic acid microspheres are composed of hyaluronic acid encapsulated in castor seed oil.

[0045] Example 2: A lip gel composition for reducing wrinkles and moisturizing, comprising, by weight percentage: 0.80% dipalmitoyl hydroxyproline, 0.07% hybrid rose extract, 0.03% hyaluronic acid microspheres, 16% castor seed oil, 0.07% sunflower seed oil, 0.0007% β-carotene, 37% caprylic / capric triglyceride, and 46.0293% octyl dodecanol, wherein the hyaluronic acid microspheres are composed of hyaluronic acid encapsulated in castor seed oil.

[0046] Example 3: A lip gel composition for reducing wrinkles and moisturizing, comprising, by weight percentage: 1% dipalmitoyl hydroxyproline, 0.08% hybrid rose extract, 0.035% hyaluronic acid microspheres, 17% castor seed oil, 0.08% sunflower seed oil, 0.0008% β-carotene, 38% caprylic / capric triglyceride, and 43.8042% octyl dodecanol, wherein the hyaluronic acid microspheres are composed of hyaluronic acid encapsulated in castor seed oil.

[0047] Example 4: A lip gel composition for reducing wrinkles and moisturizing, comprising, by weight percentage: 1.2% dipalmitoyl hydroxyproline, 0.09% hybrid rose extract, 0.04% hyaluronic acid microspheres, 18% castor seed oil, 0.09% sunflower seed oil, 0.0009% β-carotene, 39% caprylic / capric triglyceride, and 41.5791% octyl dodecanol, wherein the hyaluronic acid microspheres are composed of hyaluronic acid encapsulated in castor seed oil.

[0048] Example 5: A lip gel composition for reducing wrinkles and moisturizing, comprising, by weight percentage: 1.5% dipalmitoyl hydroxyproline, 0.1% hybrid rose extract, 0.05% hyaluronic acid microspheres, 20% castor seed oil, 0.1% sunflower seed oil, 0.001% β-carotene, 41% caprylic / capric triglyceride, and 37.2490% octyl dodecanol, wherein the hyaluronic acid microspheres are composed of hyaluronic acid encapsulated in castor seed oil.

[0049] Example 6: A lip gel composition for reducing wrinkles and moisturizing, comprising, by weight percentage: 1% dipalmitoyl hydroxyproline, 0.05% hybrid rose extract, 0.05% hyaluronic acid microspheres, 18% castor seed oil, 0.05% sunflower seed oil, 0.001% β-carotene, 40% caprylic / capric triglyceride, and 40.8490% octyl dodecanol, wherein the hyaluronic acid microspheres are composed of hyaluronic acid encapsulated in castor seed oil.

[0050] Example 7: A lip gel composition for reducing wrinkles and moisturizing, comprising, by weight percentage: 0.5% dipalmitoyl hydroxyproline, 0.1% hybrid rose extract, 0.02% hyaluronic acid microspheres, 15% castor seed oil, 0.1% sunflower seed oil, 0.0005% β-carotene, 36% caprylic / capric triglyceride, and 48.2795% octyl dodecanol, wherein the hyaluronic acid microspheres are composed of hyaluronic acid encapsulated in castor seed oil.

[0051] Example 8: A lip gel composition for reducing wrinkles and moisturizing, comprising, by weight percentage: 1.5% dipalmitoyl hydroxyproline, 0.05% hybrid rose extract, 0.02% hyaluronic acid microspheres, 20% castor seed oil, 0.05% sunflower seed oil, 0.0005% β-carotene, 35% caprylic / capric triglyceride, and 43.3795% octyl dodecanol, wherein the hyaluronic acid microspheres are composed of hyaluronic acid encapsulated in castor seed oil.

[0052] Example 9: A lip gel composition for reducing wrinkles and moisturizing, comprising, by weight percentage: 1% dipalmitoyl hydroxyproline, 0.1% hybrid rose extract, 0.05% hyaluronic acid microspheres, 15% castor seed oil, 0.1% sunflower seed oil, 0.001% β-carotene, 41% caprylic / capric triglyceride, and 42.7490% octyl dodecanol, wherein the hyaluronic acid microspheres are composed of hyaluronic acid encapsulated in castor seed oil.

[0053] Example 10: A lip gel composition for reducing wrinkles and moisturizing, comprising, by weight percentage: 1.5% dipalmitoyl hydroxyproline, 0.05% hybrid rose extract, 0.03% hyaluronic acid microspheres, 19% castor seed oil, 0.06% sunflower seed oil, 0.0006% β-carotene, 38.5% caprylic / capric triglyceride, and 40.8594% octyl dodecanol, wherein the hyaluronic acid microspheres are composed of hyaluronic acid encapsulated in castor seed oil.

[0054] Example 11: A lip gel composition for reducing wrinkles and moisturizing, comprising, by weight percentage: 0.8% dipalmitoyl hydroxyproline, 0.08% hybrid rose extract, 0.04% hyaluronic acid microspheres, 16.5% castor seed oil, 0.08% sunflower seed oil, 0.0008% β-carotene, 37.5% caprylic / capric triglyceride, and 44.9992% octyl dodecanol, wherein the hyaluronic acid microspheres are composed of hyaluronic acid encapsulated in castor seed oil.

[0055] Example 12: A lip gel composition for reducing wrinkles and moisturizing, comprising, by weight percentage: 1.2% dipalmitoyl hydroxyproline, 0.06% hybrid rose extract, 0.02% hyaluronic acid microspheres, 17.5% castor seed oil, 0.07% sunflower seed oil, 0.0007% β-carotene, 39.5% caprylic / capric triglyceride, and 41.6493% octyl dodecanol, wherein the hyaluronic acid microspheres are composed of hyaluronic acid encapsulated in castor seed oil.

[0056] The general preparation method for Examples 1-12 above is as follows:

[0057] A method for preparing a lip gel composition that reduces wrinkles and moisturizes, as described above, includes the following steps:

[0058] Step 1: Mix octyl dodecanol, caprylic / capric triglycerides, castor seed oil, sunflower seed oil and β-carotene at 1800-2300 rpm for 45 minutes at 60-80℃ and 1-2 bar pressure to form phase A;

[0059] Step 2: Add dipalmitoyl hydroxyproline to phase A and mix at 1800-2300 rpm for 20 minutes under the same temperature and pressure to form phase B, then begin cooling.

[0060] Step 3: When the temperature drops to 20-40℃, add hybrid rose extract and microspheres containing hyaluronic acid, and mix at 1400-1800 rpm for 10 minutes under 1-2 bar pressure until completely homogenized to form a lip gel composition that reduces wrinkles and moisturizes.

[0061] This invention prepares lip gel without preservatives or synthetic pigments, and the temperature is always controlled below 80℃ to avoid the inactivation of heat-sensitive ingredients, such as amino acids and plant extracts. The preparation process is simple, with low viscosity, thinness, and easy application. It can achieve uniform dispersion of lip moisturizing active ingredients, has strong lip penetration, and has a clear effect on reducing lines and moisturizing.

[0062] Comparative Example 1 (without core): A lip gel composition comprising, by weight percentage: 0.08% hybrid rose extract, 0.04% hyaluronic acid microspheres, 18% castor seed oil, 0.08% sunflower seed oil, 0.0008% β-carotene, 43.94% caprylic / capric triglyceride, and 37.8592% octyl dodecanol, wherein the hyaluronic acid microspheres are composed of hyaluronic acid encapsulated in castor seed oil.

[0063] A method for preparing the lip gel composition as described above includes the following steps:

[0064] Step 1: Mix octyl dodecanol, caprylic / capric triglycerides, castor seed oil, sunflower seed oil and β-carotene at 1800-2300 rpm for 45 minutes at 60-80℃ and 1-2 bar pressure.

[0065] Step 2: When the temperature drops to 20-40℃, add hybrid rose extract and microspheres containing hyaluronic acid, and mix at 1400-1800 rpm for 10 minutes under 1-2 bar pressure until completely homogenized to form a lip gel composition.

[0066] Comparative Example 2 (High Oil Content): A lip gel composition comprising, by weight percentage: 1.2% dipalmitoyl hydroxyproline, 0.08% hybrid rose extract, 0.04% hyaluronic acid microspheres, 25% castor seed oil, 0.08% sunflower seed oil, 0.0008% β-carotene, 36.65% caprylic / capric triglyceride, and 36.9492% octyl dodecanol, wherein the hyaluronic acid microspheres are composed of hyaluronic acid encapsulated in castor seed oil.

[0067] A method for preparing the lip gel composition as described above includes the following steps:

[0068] Step 1: Mix octyl dodecanol, caprylic / capric triglycerides, castor seed oil, sunflower seed oil and β-carotene at 1800-2300 rpm for 45 minutes at 60-80℃ and 1-2 bar pressure to form phase A;

[0069] Step 2: Add dipalmitoyl hydroxyproline to phase A and mix at 1800-2300 rpm for 20 minutes under the same temperature and pressure to form phase B, then begin cooling.

[0070] Step 3: When the temperature drops to 20-40℃, add hybrid rose extract and microspheres containing hyaluronic acid, and mix at 1400-1800 rpm for 10 minutes under 1-2 bar pressure until completely homogenized to form a lip gel composition.

[0071] Comparative Example 3 (High Temperature): A lip gel composition comprising, by weight percentage: 1.2% dipalmitoyl hydroxyproline, 0.08% hybrid rose extract, 0.04% hyaluronic acid microspheres, 18% castor seed oil, 0.08% sunflower seed oil, 0.0008% β-carotene, 36.65% caprylic / capric triglyceride, and 43.9492% octyl dodecanol, wherein the hyaluronic acid microspheres are composed of hyaluronic acid encapsulated in castor seed oil.

[0072] A method for preparing the lip gel composition as described above includes the following steps:

[0073] Step 1: Mix octyl dodecanol, caprylic / capric triglycerides, castor seed oil, sunflower seed oil and β-carotene at 1800-2300 rpm for 45 minutes at 60-80℃ and 1-2 bar pressure to form phase A;

[0074] Step 2: Add dipalmitoyl hydroxyproline to phase A and mix at 1800-2300 rpm for 20 minutes at 95°C and 1-2 bar pressure to form phase B. Then begin cooling.

[0075] Step 3: When the temperature drops to 20-40℃, add hybrid rose extract and microspheres containing hyaluronic acid, and mix at 1400-1800 rpm for 10 minutes under 1-2 bar pressure until completely homogenized to form a lip gel composition.

[0076] Comparative Example 4 (Synthetic Additive): A lip gel composition comprising, by weight percentage: 1.2% dipalmitoyl hydroxyproline, 0.08% hybrid rose extract, 0.04% hyaluronic acid microspheres, 18% castor seed oil, 0.08% sunflower seed oil, 0.01% synthetic pigment, 36.65% caprylic / capric triglyceride, 43.44% octyl dodecanol, and 0.5% phenoxyethanol (preservative), wherein the hyaluronic acid microspheres are composed of hyaluronic acid encapsulated in castor seed oil.

[0077] A method for preparing the lip gel composition as described above includes the following steps:

[0078] Step 1: Mix octyl dodecanol, caprylic / capric triglycerides, castor seed oil, sunflower seed oil, synthetic pigments, and phenoxyethanol (preservative) at 1800-2300 rpm for 45 minutes at 60-80℃ and 1-2 bar pressure to form phase A.

[0079] Step 2: Add dipalmitoyl hydroxyproline to phase A and mix at 1800-2300 rpm for 20 minutes under the same temperature and pressure to form phase B, then begin cooling.

[0080] Step 3: When the temperature drops to 20-40℃, add hybrid rose extract and microspheres containing hyaluronic acid, and mix at 1400-1800 rpm for 10 minutes under 1-2 bar pressure until completely homogenized to form a lip gel composition.

[0081] 1. The moisturizing properties of the lip gels prepared in Examples 1-12 and Comparative Examples 1-4 were tested:

[0082] Hair was removed from the test subject's left forearm, and the same area was marked out as the test area. The initial moisture content of the test area was measured using a CK CM825-MDD skin moisture meter, ensuring the moisture content was between 40% and 45%. The initial transdermal moisture loss rate (transdermal moisture loss rate refers to the rate at which water is lost from the dermis through the epidermis per unit time; a lower transdermal moisture loss rate indicates less skin moisture loss and better moisturizing effect) was measured using a CK Tewameter™ Hex transdermal moisture loss probe. After applying the corresponding test product to the test area, the immediate moisture content, immediate transdermal moisture loss rate, and moisture content and transdermal moisture loss rate after 4 hours were measured again using the above methods. The immediate moisture change value was calculated as [(immediate moisture content - initial moisture content) / initial moisture content] * 100%, and the moisture change value after 4 hours was calculated as [(moisture content after 4 hours - initial moisture content) / initial moisture content] * 100%. The average value of the test results is shown in Table 2 below.

[0083] Table 2

[0084]

[0085]

[0086] Tests show that the composition of the present invention has better moisturizing properties for lip gels compared to the prior art.

[0087] 2. The compositions prepared in Examples 1-12 and Comparative Examples 1-4 were used to test the anti-wrinkle and firming effects of the lip gel:

[0088] Using a human dermal fibroblast model, the relative expression level of mRNA was detected by real-time quantitative PCR (RT-qPCR) as the endpoint. By comparing the difference in the relative expression level of factor mRNA between the blank control and the test substance after administration, the regulatory effect of the test substance on MMP-2 was evaluated, which can serve as one of the pieces of evidence for its firming and anti-wrinkle effects.

[0089] 2.1 Cell viability test (MTT):

[0090] Routine cell culture. Seed the cell suspension into 96-well cell culture plates and incubate for 24 hours. Dissolve 20 mg of sample in 1 mL of culture medium until fully dissolved. Add the same volume of test sample at different concentrations to each well and return to the incubator for incubation. Add MTT solution to each well and incubate. Discard the liquid in the wells, add DMSO to each well, shake well, and then measure the absorbance using a microplate reader.

[0091] 2.2 Determination of relative gene expression levels of MMP-2:

[0092] The tests were conducted according to the test protocol shown in Table 2. Routine cell culture: Cell suspension was seeded into 6-well cell culture plates and cultured for 24 hours. The culture medium was aspirated from the wells, and different treatment groups were added to each well according to the table above. The 6-well plates were returned to the cell culture incubator and cultured for another 24 hours. Cells were then collected into centrifuge tubes. RNA extraction: Sample lysis—removal of genomic DNA—RNA adsorption—removal of impurities—RNA elution—RNA purity and concentration detection. RNA reverse transcription: removal of genomic DNA—reverse transcription—obtaining cDNA. Primers, probes, and multiplex PCR reaction mixtures were prepared and dispensed into each reaction tube, with cDNA added to each. The PCR reaction program was opened, the appropriate experimental type and mode were set, and the experiment was started to obtain experimental data.

[0093] Table 3. Cell grouping and processing information for MMP-2 content testing

[0094] Group Experimental protocol detection indicators Detection methods Blank control group (B) Culture medium Relative expression level of the gene to be tested RT-qPCR Positive control group (P) Vitamin E+ culture medium Relative expression level of the gene to be tested RT-qPCR Test sample group (TA) Sample + Culture Medium Relative expression level of the gene to be tested RT-qPCR

[0095] 2.3 Relative cell viability:

[0096] Assuming the cell viability of the blank control group is 100%, calculate the relative cell viability of each group.

[0097] Relative cell activity = (OD) TA / OD B )×100%;

[0098] OD TA : The average of three measurements of the optical density of the tested sample group;

[0099] OD B The average of three measurements of optical density in the blank control group;

[0100] 2.4 Expression levels of the genes to be tested:

[0101] △CT (treatment group) = CT (test gene) - CT (mean value of internal reference gene);

[0102] △CT (control group) = CT (test gene) - CT (internal reference gene mean);

[0103] △△CT = △CT (treatment group) - △CT (control group);

[0104] Relative expression level of the gene to be tested = 2 ^-△△CT Take 2 ^-△△CT The mean.

[0105] Reference Figure 2 The MTT assay was performed according to step 2.1. This cell viability assay was designed with 8 sample concentrations (e.g., ...). Figure 1 As shown in the figure, when the sample concentration is ≤10 mg / mL, the cell viability is greater than 90%, and all samples can be used for subsequent experiments. 2.5 mg / mL, 5 mg / mL, and 10 mg / mL were selected as the concentrations for subsequent efficacy experiments.

[0106] Reference Figure 3 At a concentration of 5 mg / mL, the relative expression level of the MMP2 gene in the sample was 0.73 ± 0.04, which was significantly lower than that in the blank control group (P < 0.01). At a concentration of 10 mg / mL, the relative expression level of the MMP2 gene in the sample was 0.72 ± 0.02, which was also significantly lower than that in the blank control group (P < 0.05). This indicates that the sample at these concentrations has a downregulating effect on the MMP2 gene, demonstrating that the composition can achieve firming and anti-wrinkle effects.

[0107] 3. The compositions prepared in Examples 1-12 and Comparative Examples 1-4 were used to test the lip line improvement effect of the lip gel:

[0108] The initial lip line depth was tested before use and after 30 days of use using the MicroSkinII multifunctional dermatoscope image analysis system. The change in lip line depth was calculated as [(lip line depth after 30 days of use - initial lip line depth) / initial lip line depth] * 100%. The average value of the test results is shown in Table 4.

[0109] 4. Take the compositions prepared in Examples 1-12 and Comparative Examples 1-4, and test the user experience of the lip gel:

[0110] Testers evaluated the lip gel's feel, moisturizing effect, and improvement effect after 30 days of use. Feel: 0-5 points, where 0 points indicates a heavy, sticky texture, and 5 points indicates a refreshing, non-sticky texture; Moisturizing effect: 0-5 points, where 0 points indicates a superficially moisturizing and tight feeling, and 5 points indicates moisturizing without tightness; Improvement effect: 0-5 points, where 0 points indicates no improvement in lip roughness and uneven lips, and 5 points indicates a significant improvement in lip roughness and smooth, hydrated lips. The test results were averaged. See [link to test results]. Figure 1 .

[0111] Table 4

[0112]

[0113]

[0114] Refer to Table 4 and Figure 1 Tests show that the composition of the present invention has a better effect on improving lip lines compared with the prior art.

[0115] The principle of this invention is as follows: This invention relates to the field of cosmetic technology, specifically disclosing a lip gel composition for reducing wrinkles and moisturizing, and its preparation method. The composition comprises, in specific proportions, dipalmitoyl hydroxyproline (0.5-1.5%), hybrid rose extract (0.05-0.1%), microspheres of ultra-low molecular weight hyaluronic acid encapsulated in castor seed oil (0.02-0.05%), castor seed oil (15-20%), sunflower seed oil (0.05-0.1%), β-carotene (0.0005-0.001%), and a moisturizing agent matrix (caprylic / capric triglycerides 35-41%, octyl dodecanol 32-50%). The preparation employs a staged low-temperature mixing process: first, an oil phase carrier is formed at 60-80℃, then a collagen activator is added for dispersion, and finally, heat-sensitive active ingredients are integrated at ≤40℃. This solution breaks through the limitations of traditional lip products where efficacy and skin feel cannot be achieved simultaneously. Tests have shown that after 30 days of use, lip lines are reduced by more than 40%, and hydration is increased by more than 60% after 4 hours. Moreover, no synthetic preservatives or synthetic pigments are added throughout the entire process.

[0116] The embodiments described herein are preferred embodiments of the present invention and are not intended to limit the scope of protection of the present invention. Therefore, all equivalent changes made in accordance with the structure, shape, and principle of the present invention should be covered within the scope of protection of the present invention.

Claims

1. A lip gel composition for reducing wrinkles and moisturizing, characterized in that, The composition comprises, by weight percentage: 0.5-1.5% dipalmitoyl hydroxyproline, 0.05-0.1% hybrid rose extract, 0.02-0.05% hyaluronic acid microspheres, 15-20% castor seed oil, 0.05-0.1% sunflower seed oil, 0.0005-0.001% β-carotene, 35-41% caprylic / capric triglycerides, and 32-50% octyl dodecanol. The hyaluronic acid microspheres are composed of hyaluronic acid encapsulated in castor seed oil. The composition does not contain synthetic preservatives or synthetic pigments, and the temperature is always ≤80°C during the preparation of the composition.

2. The lip gel composition according to claim 1, characterized in that, The hyaluronic acid microspheres have a molecular weight of less than 10 kDa, and the mass ratio of castor oil to hyaluronic acid is (8-12):

1.

3. The lip gel composition according to claim 1, characterized in that, The mass ratio of the octyldodecyl alcohol to the caprylic / capric triglyceride is (1.0-1.3):

1.

4. The lip gel composition according to claim 1, characterized in that, The mass ratio of dipalmitoyl hydroxyproline to the hybrid rose extract is (10-30):

1.

5. A method for preparing a lip gel composition for reducing wrinkles and moisturizing as described in any one of claims 1-4, characterized in that, Includes the following steps: Step 1: Mix octyl dodecanol, caprylic / capric triglycerides, castor seed oil, sunflower seed oil and β-carotene at 1800-2300 rpm for 45 minutes at 60-80℃ and 1-2 bar pressure to form phase A; Step 2: Add dipalmitoyl hydroxyproline to phase A and mix at 1800-2300 rpm for 20 minutes under the same temperature and pressure to form phase B, then begin cooling. Step 3: When the temperature drops to 20-40℃, add hybrid rose extract and microspheres containing hyaluronic acid, and mix at 1400-1800 rpm for 10 minutes under 1-2 bar pressure until completely homogenized to form the lip gel composition. Throughout the entire preparation process, the temperature remains ≤80℃.

6. The preparation method according to claim 5, characterized in that, In step 3, the microspheres containing hyaluronic acid are kept at a temperature ≤30℃ before mixing.

7. The use of a lip gel composition for reducing lip lines and moisturizing as described in any one of claims 1-4 in the preparation of cosmetics for reducing lip lines, characterized in that, After 30 days of use, the lip line depth reduction rate is ≥40%.

8. The use of a lip gel composition for reducing wrinkles and moisturizing as described in any one of claims 1-4 in the preparation of long-lasting moisturizing cosmetics, characterized in that, After 4 hours of use, lip moisture content increased by ≥60%.

9. A cosmetic composition, characterized in that, The lip gel composition comprising any one of claims 1-4 for reducing wrinkles and moisturizing, and a cosmetically acceptable carrier.

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