An oral care composition, use and oral care product

Abstract

The application belongs to the technical field of oral care, and discloses an oral care composition, use and oral care product. The oral care composition comprises D-3-hydroxybutyric acid and tetrasodium pyrophosphate, and the mass ratio of the D-3-hydroxybutyric acid and the tetrasodium pyrophosphate is 0.001-1:1. The application provides an oral care composition. The 3-hydroxybutyric acid and the tetrasodium pyrophosphate are compounded, so that the 3-hydroxybutyric acid and the tetrasodium pyrophosphate also exhibit excellent tooth whitening effect at a lower concentration, the use amount of the tetrasodium pyrophosphate can be effectively reduced, and thus the tooth health problem of tooth decalcification caused by long-term use of high-concentration tetrasodium pyrophosphate can be avoided.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of oral care, in particular to an oral care composition, use and oral care product. BACKGROUND

[0002] With the emphasis on oral health and aesthetics, the market demand for tooth whitening products is growing. Tooth discoloration is mainly caused by two ways of exogenous pigment deposition and endogenous pigment formation; exogenous pigments mainly come from food, beverages, tobacco, etc., and endogenous pigments are caused by factors such as excessive intake of tetracycline drugs and fluoride. At present, the common tooth whitening toothpaste on the market mainly realizes the effect of tooth whitening through physical friction and chemical removal.

[0003] Among them, the chemical removal method mostly uses tetrasodium pyrophosphate (also known as sodium pyrophosphate), sodium phytate, pentasodium triphosphate (also known as sodium triphosphate), and sodium hexametaphosphate, which have strong calcium ion chelating ability, as the active ingredient for tooth whitening. However, long-term use of these ingredients may cause tooth demineralization, and a high concentration is required in toothpaste to achieve the desired whitening effect, and high concentrations of chemical ingredients may increase the irritation to teeth and oral mucosa; at the same time, the whitening effect of a single component is limited, and it is difficult to meet the needs of consumers for fast and efficient whitening.

[0004] Therefore, it is necessary to study a composition that can efficiently whiten and protect the health of teeth, so as to achieve better tooth whitening effect at low concentration. SUMMARY

[0005] One of the purposes of the present application is to provide an oral care composition that can improve the whitening effect through the synergistic effect of components at low concentration.

[0006] Another purpose of the present application is to provide a use of an oral care composition.

[0007] Meanwhile, the present application also provides an oral care product containing the oral care composition of the present application, which can have the effects of efficient whitening and protection of tooth health.

[0008] To achieve the above purpose, the present application provides an oral care composition comprising D-3-hydroxybutyric acid and tetrasodium pyrophosphate, wherein the mass ratio of the D-3-hydroxybutyric acid and the tetrasodium pyrophosphate is 0.001-1:1.

[0009] Further, the mass ratio of the 3-hydroxybutyric acid and the tetrasodium pyrophosphate is 0.05-0.8:1.

[0010] As a preferred technical solution of this application, the 3-hydroxybutyric acid is at least one of D-3-hydroxybutyric acid, L-3-hydroxybutyric acid, and DL-3-hydroxybutyric acid.

[0011] More preferably, the 3-hydroxybutyric acid is D-3-hydroxybutyric acid.

[0012] This application also provides the use of the oral care composition described above in the preparation of oral care products.

[0013] This application further provides an oral care product containing 0.5-2 wt% of the above-described oral care composition.

[0014] The oral care products described in this application include toothpaste, mouthwash, oral spray, and other oral care products that can care for teeth; preferably, the oral care product is one of toothpaste, mouthwash, and oral spray.

[0015] Beneficial effects

[0016] Compared with the prior art, this application provides an oral care composition that combines 3-hydroxybutyric acid and tetrasodium pyrophosphate, so that 3-hydroxybutyric acid and tetrasodium pyrophosphate exhibit excellent teeth whitening effects even at low concentrations. This can effectively reduce the amount of tetrasodium pyrophosphate used, thereby avoiding dental health problems such as tooth demineralization caused by long-term use of high concentrations of tetrasodium pyrophosphate. Detailed Implementation

[0017] The present application will be further described below with reference to embodiments, but this does not constitute any limitation on the present application. Any limited modifications made within the scope of the claims of the present application shall still be within the scope of the claims of the present application.

[0018] To illustrate the technical content of this application in detail, the following description is provided in conjunction with the embodiments.

[0019] In the following examples and comparative examples, the CAS number of the D-3-hydroxybutyric acid is 625-72-9; the CAS number of the tetrasodium pyrophosphate is 7722-88-5; the CAS number of the sodium phytate is 14306-25-3; the CAS number of the pentasodium tripolyphosphate is 7758-29-4; and the CAS number of the sodium hexametaphosphate is 68915-31-1.

[0020] It should be noted that the technical solution of this application can be implemented by commercially available products, and the above CAS number is used to confirm its molecular structure for implementation by those skilled in the art.

[0021] In the following embodiments and comparative examples, unless otherwise specified, the parts are parts by weight and the percentage is a weight percentage.

[0022] The composition was prepared according to the formula in Table 1. The preparation method was as follows: the mixture was stirred at 1000 r / min at 55±5℃ until homogeneous.

[0023] Table 1 Oral Care Composition Formulation Table

[0024] D-3-hydroxybutyric acid (parts) Tetrasodium pyrophosphate (parts) Sodium phytate (parts) Pentasodium tri-polyphosphate (parts) Sodium hexametaphosphate (parts) Example 1 1 1 0 0 0 Example 2 0.3 1 0 0 0 Example 3 0.1 1 0 0 0 Example 4 0.05 1 0 0 0 Example 5 0.01 1 0 0 0 Example 6 0.001 1 0 0 0 Comparative Example 1 0 1 0 0 0 Comparative Example 2 1 0 0 0 0 Comparative Example 3 0 0 1 0 0 Comparative Example 4 0 0 0 1 0 Comparative Example 5 0 0 0 0 1 Comparative Example 6 0.05 0 1 0 0 Comparative Example 7 0.05 0 0 1 0 Comparative Example 8 0.05 0 0 0 1

[0025] Whitening efficacy test

[0026] Test methods

[0027] Evaluation methods for removing extrinsic tooth stains:

[0028] The compositions of Examples 1-6 and Comparative Examples 1-8 were each prepared into 1% aqueous solutions for stain removal testing.

[0029] Referring to the experimental methods in "T / COCIA 26—2024 Efficacy Evaluation of Oral Hygiene Products for the Prevention and Decomposition of Extrinsic Tooth Stains in Vitro", HAP tablets were soaked in black tea solution for 3 minutes, removed, rinsed with deionized water to remove any residual liquid, and blotted dry with a paper towel. The Lab value of the HAP tablets was measured using a colorimeter and recorded. After testing, the HAP tablets were soaked in the aqueous solution of the composition to be tested for 2 minutes, removed, rinsed, blotted dry, and the Lab value was measured again. The difference in L value between the HAP staining and bleaching results was compared, where ΔL value = L value after bleaching - L value after staining. The larger the ΔL value, the stronger the ability to remove extrinsic tooth stains and the better the stain removal effect.

[0030] Examples 1-6 and Comparative Examples 1-8 were tested according to the above method, and the results are shown in Table 2.

[0031] Table 2. Whitening efficacy test results of Examples 1-6 and Comparative Examples 1-8

[0032] Depigmentation effect ΔL value Example 1 8.03 Example 2 9.56 Example 3 11.53 Example 4 10.93 Example 5 9.13 Example 6 8.39 Comparative Example 1 6.43 Comparative Example 2 0.06 Comparative Example 3 3.85 Comparative Example 4 3.69 Comparative Example 5 4.52 Comparative Example 6 3.62 Comparative Example 7 3.75 Comparative Example 8 4.08

[0033] According to the results in Table 2:

[0034] Based on the data from Comparative Examples 1-5, in terms of teeth whitening effect, at a concentration of 1%, tetrasodium pyrophosphate > sodium hexametaphosphate > pentasodium tripolyphosphate > sodium phytate > D-3-hydroxybutyric acid.

[0035] However, as can be seen from Examples 1-6 of this application, when tetrasodium pyrophosphate and D-3-hydroxybutyric acid are used in combination, the stain removal effect of the composition can be significantly improved. It can be inferred that the combination of tetrasodium pyrophosphate and D-3-hydroxybutyric acid has a synergistic effect on improving the teeth whitening effect of the composition. Generally, the higher the concentration of D-3-hydroxybutyric acid in the composition, the more obvious the synergistic effect and the higher the stain removal effect ΔL value. However, the technical solution of Example 2, with a ratio of D-3-hydroxybutyric acid to tetrasodium pyrophosphate of 0.3:1, produced an exception. Its stain removal effect was weaker than that of Examples 3 and 4, and even similar to that of Example 5. Therefore, it is reasonable to believe that the technical solution of this application, with a specific ratio of D-3-hydroxybutyric acid to tetrasodium pyrophosphate, can exert a better synergistic effect.

[0036] Based on the data from Examples 4 and Comparative Examples 6-8, combined with the data from Comparative Examples 1-6, it can be inferred that D-3-hydroxybutyric acid only produces a synergistic effect in enhancing the teeth whitening efficacy of the composition when combined with tetrasodium pyrophosphate. Other components that also have the ability to chelate calcium ions do not produce a synergistic effect with D-3-hydroxybutyric acid.

[0037] Based on the synergistic effect of the combination of D-3-hydroxybutyric acid and tetrasodium pyrophosphate, the applicant infers that its mechanism of whitening and protecting dental health is as follows:

[0038] 3-Hydroxybutyric acid (3-HHBPA) can precisely remove stains from tooth surfaces by forming pentacyclic chelates with colored metal ions through its hydroxyl and carboxyl groups. This is achieved without affecting the normal mineralization process or the tooth's resistance to decay. Furthermore, 3-HHBPA is weakly acidic and lipophilic, allowing it to penetrate the stain-enamel interface and disrupt the chromogen polymer. Tetrasodium pyrophosphate also has a high affinity for Ca²⁺. + The Fe³⁺ chelating action prevents remineralization of the stain matrix and inhibits tartar formation. The two work synergistically to enhance the whitening and stain removal effect, reduce the concentration of tetrasodium pyrophosphate used, and 3-hydroxybutyric acid has a relatively weak ability to chelate calcium ions. Long-term use will not cause tooth demineralization problems.

[0039] The embodiments presented herein are merely selected implementations based on combinations of all possible embodiments. The appended claims should not be limited to the embodiments described herein. Some numerical ranges used in the claims include sub-ranges within them, and variations within these ranges should also be covered by the appended claims.

Claims

1. An oral care composition characterized in that, consisting of D-3-hydroxybutyric acid and tetrasodium pyrophosphate in a mass ratio of 0.001-1:

1.

2. The oral care composition of claim 1, wherein, The mass ratio of the D-3-hydroxybutyric acid and tetrasodium pyrophosphate is 0.05-0.8:

1.

3. Use of an oral care composition as claimed in claim 1 or 2 for the manufacture of an oral care product.

4. An oral care product characterised in that, containing 0.5-2 wt% of an oral care composition as claimed in claim 1 or 2.

5. The oral care product of claim 4, wherein, The oral care product comprises one of a toothpaste, a mouthwash, an oral spray.