Traditional Chinese medicine skin chemical stripping reagent and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine skin chemical stripping reagent and a preparation method thereof. The reagent comprises a saturated potassium hydroxide solution, glutinous rice, gallnut, glycerol and a centella asiatica extract which form a functional formula based on the compatibility principle of monarch, minister, assistant and guide. The preparation method comprises the steps of weighing, crushing, multi-stage stirring, filtering and cooling, closed packaging and the like, and is clear in process parameters and clear in operation path. The reagent is suitable for removing cuticles, the using method comprises dispensing, standing and flushing, the whole stripping process is mild, and the adaptability is high. Compared with traditional tartaric acid and salicylic acid exfoliating agents, the reagent is low in irritation, natural in structure and stable in formula, has the dual functions of exfoliating, repairing and conditioning, is suitable for improving various pigment increase type skin diseases, and has a good treatment effect on lesions located at the positions difficult to operate such as the nose, the lip periphery and the eye periphery. The technical scheme has good safety, ingredient controllability and popularization prospect, and is suitable for being used in the fields of orthopaedic surgery and dermatology department.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of skin external preparation, in particular to a traditional Chinese medicinal material skin chemical peeling reagent and a preparation method thereof. BACKGROUND

[0002] Skin chemical peeling technology is a common external method for promoting skin renewal and treatment by controllable dissolution or peeling of the epidermal keratin layer through chemical agents, and is widely used in the treatment of skin problems such as acne, pigmentation, photoaging, enlarged pores and keratin accumulation. The main peeling agents on the market currently mainly include AHA, BHA, TCA and phenol components. These reagents have certain exfoliation and renewal effects, but generally have the following technical defects:

[0003] Firstly, strong irritation and high side effects. Traditional peeling agents rely on high-concentration acid chemical reactions, which can easily cause burning sensation, erythema, edema and even epidermal burns, especially in strong peeling agents such as TCA, which can easily induce pigmentation or postoperative chronic inflammation, and sensitive skin groups are more difficult to tolerate.

[0004] Secondly, complex preparation and high storage requirements. Multi-component complex peeling agents such as Jessner solution need to strictly control the proportion and environment during preparation, and some components (such as salicylic acid) are sensitive to oxidation and light, and need to be refrigerated and protected from light, which is difficult to store and transport regularly.

[0005] Thirdly, lack of repair support mechanism. Most traditional peeling agents lack auxiliary components for barrier reconstruction and inflammation regulation after peeling, and the skin is vulnerable after peeling, which can easily cause secondary infection or prolong the recovery period.

[0006] Therefore, there is an urgent need for a traditional Chinese medicine peeling agent with natural ingredients, mild peeling, scientific compatibility, controllable preparation, and repair and protection functions to solve the technical problems of traditional technology in irritation, recovery period and preparation industrialization. SUMMARY

[0007] The purpose of the present application is to provide a traditional Chinese medicinal material skin chemical peeling reagent, which has the advantages of mild peeling, natural ingredients, simple structure and low side effects, and solves the problems of strong irritation, complex ingredients and high use threshold in existing peeling technology.

[0008] To achieve the above purpose, the present application provides the following technical scheme: a traditional Chinese medicinal material skin chemical peeling reagent, which is composed of the following components:

[0009] The monarch component is a saturated potassium hydroxide solution;

[0010] The minister component is glutinous rice;

[0011] The assistant component is gallnut;

[0012] Auxiliary repair components: glycerin, centella asiatica extract.

[0013] Preferably, the mass ratio of each component is as follows:

[0014] Saturated potassium hydroxide solution: 20-30 g;

[0015] Waxy rice: 2.0-5.0 g;

[0016] Gallnut: 1.5-3.0 g;

[0017] Glycerin: 0.5-2.0 g;

[0018] Centella asiatica extract: 0.1-0.5 g.

[0019] Preferably, the mass ratio of each component is as follows:

[0020] Saturated potassium hydroxide solution: 24 g;

[0021] Waxy rice: 3.5 g;

[0022] Gallnut: 2.0 g;

[0023] Glycerin: 1.0 g;

[0024] Centella asiatica extract: 0.3 g.

[0025] A preparation method of a traditional Chinese medicine skin chemical exfoliation reagent, comprising the following steps:

[0026] S1, raw material weighing and pretreatment:

[0027] S1.1: Weigh each of the raw materials of saturated potassium hydroxide solution, waxy rice, gallnut, glycerin and centella asiatica extract, and control the weighing accuracy within ±0.1 g;

[0028] S1.2: After crushing the gallnut and centella asiatica extract, pass them through an 80-mesh screen to prepare fine powder;

[0029] S2, base solution preparation and preliminary mixing:

[0030] S2.1: Add saturated potassium hydroxide solution to an alkali-resistant reaction container, set the stirring rate to 300 rpm, and control the temperature at 25±2℃;

[0031] S2.2: Add glycerin and centella asiatica extract in sequence, continue stirring for 10 minutes to make them fully dissolved and form a preliminary mixed solution;

[0032] S3, active ingredient stepwise addition and main mixing reaction:

[0033] S3.1: After the glutinous rice is soaked in pure water for 30 minutes, it is drained and slowly added to the above mixture, and stirred for 15 minutes to make it evenly dispersed to form a milky structure;

[0034] S3.2: Add more gallnut powder, stir for 5-10 minutes to promote the full integration of the ingredients and form a homogeneous mixture system;

[0035] S4, filtration, cooling and packaging:

[0036] S4.1: The mixture is coarsely filtered through a stainless steel screen with a pore size of 200 μm to remove insoluble particles;

[0037] S4.2: The filtered mixture is naturally cooled for 10 minutes, and then filled into a high-closed light-shielding container under clean conditions to complete the packaging of the finished product.

[0038] Preferably, in step S1.2, the gallnut and centella asiatica extract are pulverized by high-speed airflow milling, the processing time is controlled at 5-8 minutes, and then placed in a hot air drying oven at 60±2℃ for drying for 2 hours, and the moisture content at the end of drying is less than 5%.

[0039] Preferably, in step S3.1, the glutinous rice is pretreated with pure water, the pretreatment temperature is controlled at 25±1℃, and the pure water used is sterile water treated by 0.22 μm filter membrane, and the soaking is completed by vacuum filtration.

[0040] Preferably, the stirring process involved in steps S2.1 to S3.2 includes the following three stages:

[0041] In step S2.1, the stirring mode is magnetic stirring, using uniform speed mode, the stirring rate is 200 rpm, and the duration is 5 minutes, which can initially activate the potassium hydroxide system;

[0042] In steps S2.2 and S3.1, the stirring mode is switched to intermittent mechanical stirring, the stirring rate is set to 250 rpm, and the cycle mode of stirring for 2 minutes and stopping for 1 minute is adopted, the total duration is 5 minutes, which can promote the full dispersion of glycerol, centella asiatica extract and glutinous rice;

[0043] In step S3.2, after adding gallnut, continuous high-speed mechanical stirring is adopted, the stirring rate is increased to 350 rpm, and the stirring duration is 10 minutes, which can form a homogeneous and stable mixture system.

[0044] Preferably, in step S4.2, the cleanliness of the filling environment is controlled to be above ISO 8 level, the packaging process adopts double sealing structure of aluminum film heat sealing and mechanical screw cap, and the obtained packaging bottle has light transmittance ≥ 99% and air tightness test qualified rate ≥ 95%.

[0045] Compared with the prior art, the application has the following beneficial effects:

[0046] 1、The structure combination is scientific, and a functional closed loop is formed. The application adopts the "monarch-subordinate-minister and assistant" matching principle in traditional Chinese medicine prescriptions, reasonably introduces components such as saturated potassium hydroxide (peeling main effect), glutinous rice (physical buffering), gallnut (anti-inflammatory astringent), glycerol and asiatic pennywort extract (repair and moisturizing), and constructs an "peeling-repair-protection" integrated action mechanism, solving the problem of insufficient postoperative tissue support of traditional peeling agents.

[0047] 2、The peeling process is mild and has strong adaptability. The reagent does not contain strong irritating components such as high-concentration fruit acid and TCA. The keratin is dissolved through a mild alkaline mechanism, and the glutinous rice emulsion buffer and the gallnut antibacterial astringent are supplemented, which significantly reduces the discomfort and postoperative irritation caused by peeling, and is especially suitable for sensitive skin groups.

[0048] 3、The process parameters are clear, and have industrial landing nature. The application clearly defines key preparation parameters such as raw material screening, stirring rate, temperature control, and packaging cleanliness, has good production consistency and scaling feasibility, and is conducive to pilot conversion and product scale preparation.

[0049] 4、The formula is natural and simple, and has high safety. All components are clearly sourced, traceable, and controllable in proportion, avoiding problems such as incompatible components, uncontrollable irritation, and the like in traditional composite acid peeling products. The product retains repairability while simplifying the formula system, reducing the risk of adverse reactions. BRIEF DESCRIPTION OF DRAWINGS

[0050] Figure 1 It is a skin chemical peeling reagent formula structure diagram in the application;

[0051] Figure 2 It is a preparation flowchart of the peeling reagent;

[0052] Figure 3 It is a use method flowchart of the peeling reagent;

[0053] Figure 4 It is a treatment follow-up effect display Figure 1 ;

[0054] Figure 5 It is a treatment follow-up effect display Figure 2 . DETAILED DESCRIPTION

[0055] With reference to the drawings of the embodiments of the present application, the technical solutions in the embodiments of the present application will be clearly and completely described. Obviously, the described embodiments are only a part of the embodiments of the present application, rather than all the embodiments of the present application. Based on the embodiments of the present application, all other embodiments obtained by a person of ordinary skill in the art without creative work fall within the protection scope of the present application.

[0056] Please refer to Figures 1 to 5 The present application provides a traditional Chinese medicine skin chemical peeling agent and a preparation method thereof. The agent has clear structure, reasonable compatibility, simple preparation process and controllable parameters, and has the characteristics of mild peeling, barrier friendliness, repair supportability and wide application scenarios. The agent is suitable for auxiliary removal and daily conditioning of non-break skin problems such as keratin layer accumulation, rough skin and mild closed comedones.

[0057] I. Component structure and action mechanism

[0058] The present application constructs a formula structure composed of five kinds of traditional Chinese medicine / functional ingredients. According to the compatibility logic of "monarch, minister, assistant and guide" in traditional Chinese medicine, the components form clear division of labor and functional synergy.

[0059] Monarch: saturated potassium hydroxide solution

[0060] Potassium hydroxide is a strong base that can rapidly hydrolyze the intercellular junction structure (mainly keratin and lipid layer) of the keratin layer under external use conditions, achieving the peeling and exfoliation of epidermal dead skin cells. Its action mechanism relies on the alkaline destruction of the intercellular barrier to release the extracellular matrix, and it is commonly used in mild degreasing and keratolytic systems. In the present application, its peeling force is the main axis function, but it needs to be matched with a buffer structure to control the penetration force.

[0061] Minister: glutinous rice

[0062] Glutinous rice is rich in amylopectin and plant polysaccharides, and forms a high-adhesion hydrogel film after being exposed to water, which has dual functions:

[0063] Physical level: form a surface slow-release film to slow down the penetration rate of potassium hydroxide and avoid damage to deep tissues;

[0064] Physiological level: its natural amino acids such as arginine and glutamic acid can provide a nutrient microenvironment to improve postoperative skin recovery efficiency. Glutinous rice film can also adsorb part of the alkali solution to reduce the peak concentration of irritation.

[0065] Assistant: gallnut

[0066] Gallnut is rich in tannic acid (tannin macromolecular phenols), which has the following advantages:

[0067] Tannic acid can form a precipitated protective film with keratin, effectively "sealing" open skin lesions;

[0068] The peroxidase activity can be inhibited by metal ion chelation to relieve postoperative redness;

[0069] The bacteriostatic spectrum is wide, and has certain broad-spectrum antibacterial performance, so that the risk of secondary infection of the exfoliation site is reduced.

[0070] Auxiliary repair components: glycerin and centella asiatica extract

[0071] Glycerin: The trihydroxy alcohol structure provides excellent moisturizing and sebum membrane repair capabilities for it, can maintain the hydration state of the stratum corneum, and buffer the dehydration effect;

[0072] Centella asiatica extract: contains hydroxyl asiatic acid and asiaticoside, and modern research shows that it can promote the generation of type I and type III collagen, enhance the migration speed of fibroblasts, and accelerate the reconstruction of barrier function.

[0073] In summary, a structural functional closed loop is formed among the five components, achieving the whole process of "exfoliation-buffering-calming-repairing" cooperation.

[0074] II. Preparation process and key parameter control

[0075] The present application provides a kind of exfoliation reagent preparation method based on industrial amplification, comprising the following steps:

[0076] S1, raw material weighing and pretreatment

[0077] S1.1: weigh the saturated potassium hydroxide solution, glutinous rice, gallnut, glycerin and centella asiatica extract respectively, use electronic balance operation, weighing error ≤±0.1g, record number to ensure traceability;

[0078] S1.2: gallnut and centella asiatica extract are pulverized by high-speed airflow mill, the processing time is 5-8 minutes, the particle size D50 is controlled to be 20-40 μm; then it is placed in a hot air drying oven at 60±2℃ and dried for 2 hours, the residual moisture is controlled to be ≤5%, to prevent agglomeration.

[0079] Note: If drying and particle size control are not performed, it may cause uneven mixing, local settlement or uncontrolled reaction rate, etc.

[0080] S2, base solution preparation and preliminary mixing

[0081] S2.1: inject the saturated potassium hydroxide solution into a clean alkali-resistant reaction container, the stirring mode is magnetic stirring, set 200 rpm, maintain the temperature at 25±2℃;

[0082] S2.2: under continuous stirring, glycerin and centella asiatica extract powder are added in turn, and the solution is stirred for 10 minutes until it is clear.

[0083] Note: Glycerin is added in sequence, which can improve the dispersibility of the powder. Adding Centella asiatica after the base solution helps it dissolve fully in the base solution.

[0084] S3, Active substance step-by-step addition and main mixing reaction

[0085] S3.1: Glutinous rice is soaked in purified water at 25±1°C for 30 minutes (the water is sterilized by a 0.22μm filter membrane in advance), then drained using vacuum filtration, and the particle shape is kept intact; slowly pour into the above-mentioned base solution, stirring rate 200rpm, time 15 minutes, forming a milky protective system;

[0086] S3.2: Add crushed gallnut powder, switch to mechanical stirring device, set three-stage mode:

[0087]

[0088] Note: The use of multi-stage stirring design helps to fully mix components of multiple particle sizes and densities, and reduces local concentration reaction points.

[0089] S4, Filtration, cooling and packaging

[0090] S4.1: The obtained mixed solution is filtered through a 200μm stainless steel screen to remove unsolved particles, ensuring that the liquid is clear and homogeneous;

[0091] S4.2: After cooling at room temperature for 10 minutes, fill in an ISO 8 clean environment, use high-closed polyethylene light-shielding bottles, use aluminum film heat sealing + mechanical screw cap double sealing to ensure light shielding rate ≥99%, and air tightness test qualified rate ≥95%.

[0092] III. Usage method and operation specification

[0093] The peeling agent can be used by plastic surgeons and dermatologists to treat various pigmentation skin diseases, especially lesions in difficult-to-operate areas such as the nose, lips, and eyes. The specific usage process is as follows:

[0094] Spotting operation: use a silicone spatula or cotton swab to evenly spot 5-10g of the agent on the treatment area, with a coating thickness of 1-2mm;

[0095] Natural standing: stand for 6-8 minutes without covering or massaging, and avoid external interference with the peeling reaction;

[0096] Rinse treatment: use 25±2°C warm water or 0.9% sodium chloride solution to rinse the surface thoroughly to ensure that the residual alkali is neutralized;

[0097] Dry and recover: use sterile absorbent gauze to gently dry, avoiding wiping damage.

[0098] Warning: It is not recommended to extend the standing time beyond 10 minutes, nor to use it on areas with open skin lesions to prevent excessive penetration.

[0099] Four, synergistic closed-loop and repair time

[0100] The core value of the formula design of the present application is:

[0101] Peeling initiation mechanism: potassium hydroxide initiates keratin dissolution in the pH 11-12 range;

[0102] Physical buffering mechanism: glutinous rice provides initial penetration control and slow-release alkaline activity;

[0103] Postoperative protection mechanism: gallnut rapidly precipitates and seals, and has anti-inflammatory and astringent properties;

[0104] Moisturizing and repair mechanism: glycerol and centella asiatica extract work together to maintain hydration and dermal matrix repair progress.

[0105] Generally within 2-4 hours after use, the skin barrier begins to enter the reconstruction period, and the centella asiatica component can significantly accelerate the barrier reconstruction period and shorten the reaction time of erythema and dry itching.

[0106] The reagent is especially suitable for sensitive skin, people with thin keratin layer, or users who are not tolerant to traditional fruit acids, and can complete "controllable peeling + synergistic repair" without breaking the skin, penetrating blood, or abnormal peeling.

[0107] Example 1: Application effect evaluation of traditional Chinese medicine skin chemical peeling reagent

[0108] Purpose of the experiment:

[0109] To verify the comprehensive performance of the traditional Chinese medicine skin chemical peeling reagent in terms of keratin layer removal efficiency, mildness of use, and skin recovery period, and to compare it with a commercially available 10% concentration fruit acid peeling agent.

[0110] I. Reagent preparation process

[0111] According to the preferred ratio of claim 3, the following is prepared:

[0112] Saturated potassium hydroxide solution: 24g

[0113] Glutinous rice: 3.5g

[0114] Gallnut: 2.0g

[0115] Glycerol: 1.0g

[0116] Centella asiatica extract: 0.3g

[0117] The specific steps are as follows:

[0118] Pre-treatment: Myrobalan and Centella asiatica extract were ground to D50 ≈ 30 μm, dried at 60°C for 2 hours, humidity < 5%;

[0119] Base preparation: Potassium hydroxide + glycerol + Centella asiatica powder were stirred for 10 min, temperature control at 25°C;

[0120] Rice soaking: Soaked in purified water at 25°C for 30 min, vacuum filtration and drained;

[0121] Mixing and stirring: After adding rice, stir for 15 min, then add myrobalan, stir for 5+5+10 min (three stages) in sequence;

[0122] Coarse filtration and filling: After filtering with 200 μm metal screen, fill in 100 mL polyethylene light-shielded bottle in ISO 8 level environment and seal.

[0123] II. Experimental design

[0124] Reagent groups:

[0125] Experimental group: Reagent of the present application

[0126] Control group: Commercially available 10% fruit acid peel solution

[0127] Volunteer information:

[0128] A total of 20 healthy volunteers (gender balanced, 20-40 years old) were recruited; each person divided the left and right areas on the back: left for the experimental group, right for the control group; usage time: single use, monitored for 7 days.

[0129] III. Operation process (same as Figure 3 the)

[0130] Uniformly point-coat 1-2 mm thick reagent layer;

[0131] The standing time is controlled at 6 minutes;

[0132] Use 0.9% sodium chloride solution for flushing;

[0133] Use sterile gauze to gently absorb and dry the treatment area;

[0134] Record the skin state changes every 24 hours.

[0135] IV. Evaluation index

[0136]

[0137] V. Experimental results

[0138]

[0139]

[0140] VI. Results analysis and summary:

[0141] The reagent prepared by the application has peel-off efficiency close to that of traditional fruit acid peeling agent, significantly reduces skin discomfort and irritation reaction, and shortens the recovery period by more than 2 days. The mildness and repair advantage are significant.

[0142] The overall performance confirms that the application provides a traditional Chinese medicine peeling reagent solution with higher safety, stronger controllability, simpler structure and more coordinated compatibility, which has practical use value and good market adaptation potential.

[0143] Although embodiments of the application have been shown and described, it is to be understood that the application is not limited to these embodiments. Since modifications, equivalents, replacements, and variations of these embodiments can be understood by those of ordinary skill in the art without departing from the principles and spirit of the application, the scope of the application is defined by the appended claims and their equivalents.

Claims

1. A chemical peeling agent for the skin of traditional Chinese medicinal materials, characterized in that, It consists of the following components: Principal drug component: saturated potassium hydroxide solution; Ingredients of the herbal medicine: glutinous rice; Adjuvant component: Gallnut; Supporting repair components: glycerin, centella asiatica extract.

2. The chemical peeling agent for skin of traditional Chinese medicine according to claim 1, characterized in that, The mass ratio range of each component is as follows: Saturated potassium hydroxide solution: 20-30g; Glutinous rice: 2.0–5.0g; Gallnut: 1.5–3.0g; Glycerin: 0.5–2.0 g; Centella asiatica extract: 0.1–0.5 g.

3. The chemical peeling agent for skin of traditional Chinese medicine according to claim 2, characterized in that, The mass ratios of each component are as follows: Saturated potassium hydroxide solution: 24g; Glutinous rice: 3.5g; Gallnut: 2.0g; Glycerin: 1.0g; Centella Asiatica extract: 0.3g.

4. A method for preparing a chemical peeling agent for the skin of traditional Chinese medicinal materials, applied to the peeling agent described in any one of claims 1 to 3, characterized in that, Includes the following steps: S1. Raw material weighing and pretreatment: S1.1: Weigh each of the following raw materials separately: saturated potassium hydroxide solution, glutinous rice, gallnut, glycerin, and centella asiatica extract, with weighing accuracy controlled within ±0.1g; S1.2: The extracts of Gallnut and Centella Asiatica are pulverized and passed through an 80-mesh sieve to prepare a fine powder; S2. Base liquid preparation and initial mixing: S2.1: Add saturated potassium hydroxide solution to an alkali-resistant reaction vessel, set the stirring speed to 300 rpm, and control the temperature at 25±2℃; S2.2: Add glycerin and Centella asiatica extract in sequence, and stir continuously for 10 minutes to fully dissolve and form a preliminary mixture; S3. Active ingredients are added stepwise and react with the main mixture: S3.1: Soak glutinous rice in purified water for 30 minutes, drain, and slowly add it to the above mixture. Continue stirring for 15 minutes to disperse it evenly and form an emulsion structure. S3.2: Add gallnut powder and stir for 5-10 minutes to promote full integration of the components and form a homogeneous mixture system; S4. Filtering, cooling, and encapsulation: S4.1: The mixture is coarsely filtered through a stainless steel metal sieve with a pore size of 200μm to remove insoluble particles; S4.2: After filtration, allow the mixture to cool naturally for 10 minutes, then fill it into a highly sealed, light-proof container under clean conditions to complete the finished product packaging.

5. The method for preparing a chemical peeling agent for the skin of traditional Chinese medicine according to claim 4, characterized in that: In step S1.2, the gallnut and centella asiatica extracts were pulverized using a high-speed air jet mill, with the processing time controlled at 5 to 8 minutes. After that, they were placed in a hot air drying oven at 60±2℃ for 2 hours to dry until the moisture content at the drying endpoint was less than 5%.

6. The method for preparing a chemical peeling agent for skin of traditional Chinese medicine according to claim 4, characterized in that: In step S3.1, the glutinous rice is pretreated with purified water at a temperature of 25±1℃. The purified water used is sterile water that has been sterilized by a 0.22μm filter membrane. After soaking, the rice is drained by vacuum filtration.

7. The method for preparing a chemical peeling agent for the skin of traditional Chinese medicine according to claim 4, characterized in that: The stirring process involved in steps S2.1 to S3.2 includes the following three stages: In step S2.1, the stirring method is magnetic stirring, using a uniform speed mode, with a stirring rate of 200 rpm for 5 minutes, to initially activate the potassium hydroxide system; In steps S2.2 and S3.1, the stirring mode is switched to intermittent mechanical stirring, the stirring speed is set to 250 rpm, and a cycle of stirring for 2 minutes and stopping for 1 minute is adopted, with a total duration of 5 minutes, to promote the full dispersion of glycerin, centella asiatica extract and glutinous rice; In step S3.2, after adding gallnuts, continuous high-speed mechanical stirring is used, with the stirring rate increased to 350 rpm and stirring continued for 10 minutes to form a homogeneous and stable mixed liquid system.

8. The method for preparing a chemical peeling agent for the skin of traditional Chinese medicine according to claim 4, characterized in that: In step S4.2, the cleanliness of the filling environment is controlled to be above ISO Class 8 standard, and the sealing process adopts a double sealing structure of aluminum film heat sealing and mechanical screw capping. The resulting packaging bottle has an opacity of ≥99% and an airtightness test pass rate of ≥95%.

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