Valve assembly and radioactive microsphere infusion system

Abstract

The invention relates to the field of valve assemblies and infusion systems, and provides a valve assembly and a radioactive microsphere infusion system comprising the valve assembly. The valve assembly comprises a valve body, a valve element, a first needle body and a second needle body. The valve body comprises a valve main body provided with a cavity, and a first opening, a second opening, a third opening and a fourth opening which are communicated with the cavity; the valve element is rotatably arranged in the cavity, so that a first channel, a second channel and a third channel are formed in the valve assembly. The first needle body is communicated with the third opening, and the second needle body is communicated with the fourth opening. The radioactive microsphere infusion system comprises the first pipeline, the second pipeline, the container and the valve assembly, the container can be selectively communicated with the first pipeline and the second pipeline through the valve assembly, operation steps can be simplified, and operation time can be shortened.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of valve assemblies of medical devices and infusion systems. In particular, the present application relates to an infusion system for delivering insoluble material to a living organism and a valve assembly in the infusion system. BACKGROUND

[0002] Radiopharmaceuticals are an important part of nuclear medicine, which are widely used in cancer diagnosis and treatment. The common radiopharmaceuticals are radioactive microspheres, which are insoluble materials. Currently, there are several companies that have marketed radioactive microspheres. Radioactive microspheres can be used to treat inoperable tumors, and through clinical data feedback, this method has good curative effect. In the process of delivering radioactive microspheres to the living organism, water for injection and a contrast agent also need to be used.

[0003] Figure 1 An existing infusion system 300 for delivering radioactive microspheres is shown, which works by injecting physiological saline into a conical bottom bottle 331 containing radioactive microspheres, and then injecting the microspheres in the conical bottom bottle into the human body by pressure. The infusion system 300 includes three syringes, two three-way valves, a conical bottom bottle 331, and a plurality of pipelines. The three syringes are syringe 321, syringe 322, and syringe 323, wherein the syringe 321 is used for injecting water for injection, the syringe 322 is used for injecting a contrast agent, and the syringe 323 is used for injecting water for injection and air; the two three-way valves are three-way valve 311 and three-way valve 312; the plurality of pipelines include pipelines 301, 302, 303, and 304. The connection mode of each component in the infusion system 300 is shown in Figure 1 , which will not be described here. Because the microspheres are radioactive, the infusion system 300 also includes an infusion box (not shown in Figure 1 ), in which the three-way valve 311 and the conical bottom bottle 331 are located, which can reduce the radiation of the microspheres to the operator.

[0004] The procedure for delivering radioactive microspheres using infusion system 300 is as follows: First, before connecting the tubing, air must be purged from each tubing. Then, manually operate the three-way valve 311 in the infusion tank to connect tubing 301 and 302. Manually adjust the three-way valve 312 to connect syringes 321 and 322 sequentially to tubing 302, thereby injecting contrast agent and water for injection sequentially into tubing 301 to determine the surgical location. Next, manually operate the three-way valve 311 to connect tubing 301 to tubing 303, injecting water for injection from syringe 323 (connected to tubing 304) into conical flask 331. The microspheres in conical flask 331, along with the water for injection, are then delivered into the organism via tubing 303 and 301. During the microsphere infusion process, contrast agent needs to be frequently injected from syringe 322, and the operating procedure is the same as before. In addition, syringe 323 needs to draw air in, injecting the air from syringe 323 into conical flask 331, thereby injecting all the microspheres in conical flask 331 into the organism. The specific operation method for syringe 323 drawing air and three-way valve 311 is as follows: open the infusion tank cap, lift the long needle connected to tubing 304 from conical flask 331 above the liquid surface, draw air in syringe 323, and then manually operate three-way valve 311 to connect tubing 301 and tubing 303, injecting the air from syringe 323 into conical flask 331. Figure 1 The transport system shown is too complicated and prone to errors when transporting radioactive microspheres. Summary of the Invention

[0005] To address the aforementioned technical problems, this disclosure provides a valve assembly for an infusion system, and a radioactive microsphere infusion system including the valve assembly.

[0006] The first aspect of this disclosure discloses a valve assembly for an infusion system, including a valve body, a valve core, a first needle body, and a second needle body. The valve body includes a valve body having a cavity and a first opening, a second opening, a third opening, and a fourth opening communicating with the cavity. The valve core is rotatably disposed within the cavity, forming a first channel, a second channel, and a third channel within the valve assembly. The first needle body communicates with the third opening, and the second needle body communicates with the fourth opening. When the valve core is in a first position, the first opening and the second opening communicate to form the first channel; when the valve core is in a second position, the first opening and the third opening communicate to form the second channel, and the second opening and the fourth opening communicate to form the third channel.

[0007] In some embodiments, the valve core is provided with a partition plate, the partition plate is rotatably arranged in the cavity. When the valve core is in the first position, the surface of at least one side of the partition plate defines the first channel. Further, the valve body is provided with a blocking step in the cavity, the blocking step together with the partition plate defines the first channel when the valve core is in the first position. Preferably, the cavity is configured as a column, the cavity is coaxially arranged with the valve core, and the blocking step is configured as two, one of which is arranged close to the first opening, and the other is arranged close to the second opening.

[0008] In other embodiments, the valve core is provided with a partition block, the partition block is provided with a valve core channel. When the valve core is in the first position, the first channel is at least partially formed by the valve core channel. Preferably, the lateral dimension of the partition block on both sides is greater than the lateral dimension of the middle part of the partition block.

[0009] Further, the distance from the center of the valve core to the free end of the first needle is greater than the distance from the center of the valve core to the free end of the second needle. Preferably, the first needle and the second needle are arranged in parallel, and the interval distance between the free end of the first needle and the free end of the second needle is 3-12 mm.

[0010] Optionally, the valve body includes a connecting body arranged on the outer periphery of the valve main body, the connecting body includes a tapered portion, the extension directions of the first needle and the second needle are both parallel to the axis of the tapered portion, and the first needle and the second needle extend through the tapered portion, and most of the tapered portion is close to the valve main body.

[0011] The second aspect of the present disclosure discloses a radioactive microsphere infusion system, which includes a first pipeline, a second pipeline, a container, and a valve assembly provided by the first aspect of the present disclosure. The first opening of the valve assembly is connected to the first pipeline, the second opening of the valve assembly is connected to the second pipeline, and the container is connected to the valve assembly through the first needle and the second needle. When the valve core is in the first position, the container is isolated from the first pipeline and the second pipeline; when the valve core is in the second position, the container is in communication with the first pipeline and the second pipeline.

[0012] Optionally, the infusion system further includes an actuating member coupled to the valve core, the actuating member is used to drive the valve core to rotate between the first position and the second position. Preferably, the valve core is provided with a knob arranged on the outer side of the valve body, and the actuating member is configured as an operating rod, one end of the operating rod is provided with a coupling feature coupled to the knob, and the operating rod is detachably connected to the knob.

[0013] Optionally, the infusion system further includes an infusion box and a support, the container and the valve assembly are located in the infusion box, the support is connected to the valve assembly, and the support is coupled to the infusion box. The support has a first longitudinal position and a second longitudinal position, when the support is in the first longitudinal position, the first needle and the second needle are located in the container and the second needle is in communication with the liquid in the container; when the support is in the second longitudinal position, the first needle and the second needle are located outside the container.

[0014] The features and advantages of the present disclosure include:

[0015] The valve assembly of the present disclosure is provided with four openings and two needles. By controlling the rotating position of the valve core, a first channel, a second channel and a third channel can be formed in the valve assembly. When the valve core is in a first position, the first opening and the second opening are in communication to form the first channel. When the valve core is in a second position, the first opening and the third opening form the second channel, and the fourth opening and the second opening are in communication to form the third channel. In particular, the spacing between the free ends of the two needles can be customized according to the size of the conical bottle, and the adjustable range is 3-12 mm. The microspheres in the container with a conical bottom can be completely delivered into the human body during the infusion process, which is beneficial to simplify the operation steps and reduce the operation time.

[0016] The infusion system of the present disclosure includes a valve assembly, an operating rod and a bracket. The operating rod can be coupled to the valve core of the valve assembly, so that the valve core rotates between a first position and a second position, so that the container can be selectively in communication with the flow passage. The bracket is connected to the valve assembly, and moving the bracket can longitudinally move the valve assembly to make the first needle and the second needle enter or exit the container. BRIEF DESCRIPTION OF DRAWINGS

[0017] In order to more clearly illustrate the technical solutions in the embodiments of the present disclosure, the drawings needed in the embodiment description will be briefly introduced below. Obviously, the drawings in the following description are only some embodiments of the present disclosure, and other drawings can also be obtained by those skilled in the art without creative labor.

[0018] Figure 1 A schematic diagram of an existing infusion system is shown;

[0019] Figure 2 A schematic diagram of the infusion system of the present disclosure is shown;

[0020] Figure 3 A perspective view of the valve assembly in Figure 2 is shown;

[0021] Figure 4 A schematic diagram of an embodiment of the valve assembly of the present disclosure is shown, in which the valve core of the valve assembly is in a second position;

[0022] Figure 5 A schematic diagram of an embodiment of the valve assembly of the present disclosure is shown, in which the valve core of the valve assembly is in a first position;

[0023] Figure 6 A schematic diagram of another embodiment of the valve assembly of the present disclosure is shown, in which the valve core of the valve assembly is in a second position;

[0024] Figure 7A schematic view showing another embodiment of the valve assembly of the present disclosure, wherein the spool of the valve assembly is in the first position;

[0025] Figure 8 A schematic view showing the infusion system of the present disclosure with the infusion box;

[0026] Figure 9 A schematic view showing the infusion box, the bracket, the operating rod, the valve assembly, etc. of the infusion system of the present disclosure;

[0027] Figure 10 A schematic view showing the infusion box of the present disclosure;

[0028] Figure 11 And Figure 12 A schematic view showing the bracket of the present disclosure, wherein Figure 11 The side of the bracket with the combination groove is shown, Figure 12 The side of the bracket without the combination groove is shown;

[0029] Figure 13 A schematic view showing the bracket of the present disclosure after being moved up and rotated and placed on the cover plate of the infusion box;

[0030] Figure 14 A schematic view showing the operating rod, the valve assembly, etc. of the present disclosure.

[0031] Explanation of reference signs:

[0032] 100 - valve assembly;

[0033] 10 - valve body, 11 - first opening, 12 - second opening, 13 - third opening, 14 - fourth opening, 15 - blocking step, 16 - valve main body, 17 - connecting body, 18 - first pipe body, 19 - second pipe body;

[0034] 22 - first needle body, 24 - second needle body;

[0035] 30 - spool, 32 - partition, 34 - knob;

[0036] 40 - spool, 42 - partition, 44 - spool passage, 46 - knob;

[0037] 200 - infusion system, 201 - pipeline, 202 - pipeline, 211 - three-way valve, 221 - first syringe, 222 - second syringe, 231 - container;

[0038] 240 - infusion box, 241 - box cover, 2412 - support hole, 2414 - convex part, 242 - first side wall, 2422 - first hole, 243 - second side wall, 2432 - limiting disc, 2434 - second hole, 2436 - limiting step, 2438 - limiting groove, 244 - third side wall, 2442 - third hole, 245 - fourth side wall, 246 - bottom wall;

[0039] 250 - support, 251 - support body, 2512 - combination groove, 2514 - containing part, 2516 - plate body, 252 - valve body connecting part, 2522 - containing groove, 2524 - clamping rod, 2526 - clamping plate, 2528 - limiting convex part, 253 - stop block, 255 - hand holding part;

[0040] 260 - operating rod, 261 - rod body, 262 - connecting part, 2622 - connecting groove, 263 - limiting block, 264 - handle, 265 - baffle;

[0041] 300 - infusion system, 301, 302, 303, 304 - pipeline, 311, 312 - three-way valve, 321, 322, 323 - syringe, conical bottle 331. DETAILED DESCRIPTION

[0042] The technical solutions in the embodiments of the present disclosure will be described clearly and completely below in combination with the drawings in the embodiments of the present disclosure. Obviously, the described embodiments are only part of the embodiments of the present disclosure, rather than all the embodiments. Based on the embodiments in the present disclosure, all other embodiments obtained by those skilled in the art without creative work are within the protection scope of the present disclosure.

[0043] Reference Figure 2 The present disclosure provides an infusion system 200 for delivering insoluble material, which comprises a flow channel, a container 231 and a valve assembly 100 arranged in the flow channel. The insoluble material is stored in the container 231, and the valve assembly 100 is controlled to selectively communicate the container 231 with the flow channel, so as to inject the insoluble material into the flow channel. The infusion system 200 is used for delivering the insoluble material to a living body, which can be a human body or other animals, and the insoluble material can be radioactive microspheres or other insoluble materials used for treatment. The human body and the radioactive microspheres are taken as examples for illustration. In some embodiments, the container 231 can also store water for injection, and the valve assembly 100 is controlled to selectively communicate the container 231 with the flow channel, so as to facilitate the removal of air in the flow channel. It should be noted that the container 231 storing the radioactive microspheres and the container 231 storing the water for injection can not be the same container.

[0044] Specifically, the flow path of the infusion system 200 includes a tubing 201 and a tubing 202, and the valve assembly 100 is disposed between the tubings 201, 202. The valve assembly 100 is provided with four openings and two needles, a first opening is in communication with the tubing 201, a second opening is in communication with the tubing 202, a third opening is in communication with the first needle 22, and a fourth opening is in communication with the second needle 24. In some cases, the valve assembly 100 can be controlled to make the first opening in communication with the second opening, and the third opening in communication with or not in communication with the fourth opening. In other cases, the valve assembly 100 can be controlled to make the first opening in communication with the third opening, and the fourth opening in communication with the second opening. The first needle 22 and the second needle 24 can be connected to the container 231, so that the container 231 can be selectively accessed to the flow path. One end of the tubing 201 is connected to the human body, so that the medium in the flow path can enter the human body.

[0045] The infusion system 200 further includes a three-way valve 211, a first syringe 221, and a second syringe 222. The three-way valve 211 has three ends connected to the first syringe 221, the second syringe 222, and the tubing 202, respectively. The three-way valve 211 can be controlled to selectively make the first syringe 221 and the second syringe 222 in communication with the tubing 202 (i.e., in communication with the flow path). In some embodiments, the first syringe 221 is used to store water for injection or air, and the second syringe 222 is used to store contrast agent.

[0046] The operation of delivering radioactive microspheres by the infusion system 200 includes six steps, which are sequentially air purging the tubing, pushing the microspheres, pushing the contrast agent, pushing the water for injection, continuing to push the microspheres with air, and continuing to push the water for injection. Among them, steps two to four will be repeated multiple times during the delivery process until the microspheres are almost pushed to the end, and then step five is entered. The infusion system 200 includes two containers 231, one for storing water for injection and one for storing radioactive microspheres. The container 231 for storing water for injection is only used in step one, and the containers used in the remaining steps are the containers 231 for storing radioactive microspheres.

[0047] In step one, the free ends of the first needle 22 and the second needle 24 of the valve assembly 100 are inserted below the liquid level of the container 231 storing the water for injection, and the valve assembly 100 is operated to connect the container 231 to the flow path; the three-way valve 211 is adjusted to connect the syringe 221 to the tubing 202, and the syringe 221 containing the water for injection is pushed until all the air in the tubing is discharged. At this time, the water for injection fills the interior of the valve assembly 100 and the first needle 22 and the second needle 24. In step two, the free ends of the first needle 22 and the second needle 24 are inserted below the liquid level of the container 231 containing the microsphere mixture, and the tubing 201 is connected to the human body tubing, and the water for injection in the syringe 221 is slowly pushed to allow the microspheres to enter the human body. During the pushing of the microspheres, the developer needs to be pushed at irregular intervals, and the position of the microspheres is observed. In step three, the three-way valve 211 and the valve assembly 100 are operated to connect the syringe 222 to the tubing, and the first needle 22 and the second needle 24 are disconnected from the tubing, and the developer is pushed. In step four, the three-way valve 211 is operated to connect the syringe 221 to the tubing, and the water for injection is pushed to allow the contrast agent in the tubing to completely enter the human body; and the valve assembly 100 is operated to connect the first needle 22 and the second needle 24 to the tubing. Steps two to four are repeatedly performed until the microspheres are almost completely pushed, and step five is entered. In step five, the valve assembly 100 is operated to isolate the tubing 202 from the syringes 221 and 222, and the syringe 221 is filled with air; and the valve assembly 100 is operated to reconnect the tubing 202 and the syringe 221, and the air in the syringe 221 is pushed into the container 231 storing the microsphere mixture until the microspheres are completely pushed into the tubing 201. In step six, the valve assembly 100 is operated to isolate the tubing 202 from the syringes 221 and 222, and the syringe 221 is filled with the water for injection; and the valve assembly 100 is operated to disconnect the first needle 22 and the second needle 24 from the tubing, and the water for injection is pushed by the syringe 221 until the microspheres in the tubing 221 are completely pushed into the human body.

[0048] The use of the infusion system 200 of the present disclosure facilitates the simplification of the operation of infusing radioactive microspheres into the human body. For example, in step one, the tubing is more convenient to be purged of air by using the valve assembly 100. In steps two to six, the first needle 22 and the second needle 24 are selectively connected to the tubing by operating the valve assembly 100, and since the first needle 22 and the second needle 24 are located in the container 231 and the second needle 24 is below the liquid level, the microsphere mixture in the container 231 can be selectively connected to the tubing, thereby simplifying the operation steps.

[0049] Reference will now be made to Figures 3 to 7 The valve assembly 100 of the present disclosure will be described in detail below, wherein Figure 3 A perspective view of the valve assembly 100 of the present disclosure is shown. Referring to Figure 3The valve assembly 100 includes a valve body 10, a valve core 30 or 40, a first needle body 22, and a second needle body 24. See also... Figures 3 to 5 The valve body 10 includes a valve body 16 with a cavity and a first opening 11, a second opening 12, a third opening 13, and a fourth opening 14 communicating with the cavity. A first needle body 22 communicates with the third opening 13, and a second needle body 24 communicates with the fourth opening 14. The valve core 30 is rotatably disposed in the cavity of the valve body 16, so that a first channel, a second channel, and a third channel are formed within the valve assembly 100. When the valve core 30 is in the first position, the first opening 11 and the second opening 12 communicate to form the first channel; when the valve core 30 is in the second position, the first opening 11 and the third opening 13 form the second channel, and the fourth opening 14 communicates with the second opening 12 to form the third channel.

[0050] Specifically, see Figures 3 to 5 This illustrates one embodiment of the valve assembly 100 of this disclosure. Specifically, see [link to relevant documentation]. Figure 4 and Figure 5 The cavity of the valve body 16 disclosed herein can be constructed in any shape, as long as it can accommodate the valve core 30 and form the aforementioned three channels. Specifically, the cavity of the valve body 16 can be constructed as a sphere, cylinder, cone, or other three-dimensional shape. In some embodiments, the four openings are directly disposed in the valve body 16; in other embodiments, some or all of the openings are disposed in a component of the valve body, which communicates with the cavity of the valve body 16. See also Figure 3 The valve body 10 also includes a hollow first tube 18 and a hollow second tube 19. One end of the first tube 18 forms a first opening 11, and the other end of the first tube 18 is connected to the valve body 16. One end of the second tube 19 forms a second opening, and the other end of the second tube 19 is connected to the valve body 16. The first tube 18 and the second tube 19 facilitate connection to the first conduit 201 and the second conduit 202.

[0051] Specifically, the valve core 30 is provided with a partition 32, which is rotatably disposed in the cavity of the valve body 16. When the valve core is in the first position, at least one surface of the partition 32 defines a first channel. See also Figure 5 When the valve core is in the first position, the partition 32 divides the cavity into two independent parts, one of which connects the first opening 1 and the second opening 12. At this time, the third opening 13 and the fourth opening 14 are connected to the other part, thus isolating the third opening 13 and the fourth opening 14 by the partition 32, thereby isolating the container 231 from the flow channel. See also... Figure 4 When the valve core is in the second position, the valve core still divides the cavity into two parts, one part connecting the first opening 11 with the third opening 13, and the other part connecting the fourth opening 14 with the second opening 12.

[0052] Specifically, the cavity of the valve body 16 is coaxially arranged with the valve core 30. In some embodiments, the cavity is configured as a sphere, the partition plate 32 is configured as a substantially circular plate, and the two opposite side walls of the partition plate 32 are configured as curved surfaces which are in contact with the inner side wall of the valve body 16. In other embodiments, the cavity is configured as a cylinder, the partition plate 32 is configured as a substantially rectangular plate, and the two opposite side walls of the partition plate 32 are configured as circular arcs which are in contact with the inner side wall of the valve body 16. Hereinafter, the cavity is configured as a cylinder.

[0053] In some embodiments, the valve body 10 is provided with a blocking step in the cavity of the valve body 16, and the blocking step together with the partition plate 32 defines the first channel when the valve core 30 is in the first position. The blocking step is configured to reduce the thickness of the partition plate 32. Referring to Figure 5 , the valve body 10 is provided with two blocking steps 15, one of which is arranged near the first opening and the other of which is arranged near the second opening. Specifically, one of the blocking steps 15 is arranged between the first pipe body 18 and the valve body 16, and the other of the blocking steps 15 is arranged between the second pipe body 19 and the valve body 16. Preferably, the side of the blocking step 15 near the partition plate 32 is configured as a circular arc, so that the side wall of the blocking step 15 can be in contact with the partition plate 32.

[0054] Specifically, referring to Figure 3 , Figure 4 In some embodiments, the valve body 16 is configured as a cylindrical pipe body with both ends closed, and the valve core 30 extends through one end side wall of the valve body 16 into the valve body 16. The third opening 13 and the fourth opening 14 are arranged near the lower part of the valve body 16, and the first needle body 22 and the second needle body 24 are arranged in parallel and connected to the third opening 13 and the fourth opening 14, respectively. The first pipe body 18 and the second pipe body 19 are arranged on the opposite sides of the outer periphery of the valve body 16, respectively. When the valve core 30 is in the first position, the partition plate 32 is in a horizontal position, and when the valve core is in the second position, the partition plate 32 is in a vertical position.

[0055] The valve body 10 further comprises a connecting body 17 arranged on the outer periphery of the valve body, and the first needle body 22 and the second needle body 24 extend through the connecting body 17. The connecting body 17 is configured to be connected to the opening of the container 231. Specifically, the connecting body 17 is connected to the lower part of the valve body 16, and the connecting body 17 comprises a tapered part, the extending directions of the first needle body and the second needle body are parallel to the axis of the tapered part, and the major part of the tapered part is close to the valve body 16. The major part of the tapered part refers to the part with a large cross section. The first needle body 22 and the second needle body 24 each comprise a free end and a fixed end, wherein the free end of each refers to the end away from the valve body 16, and the fixed end of each refers to the end fixed to the valve body 16. Preferably, the distance from the center of the valve core 30 to the free end of the first needle body 22 is greater than the distance from the center of the valve core 30 to the free end of the second needle body 24. In some embodiments, the first needle body 22 and the second needle body 24 are arranged in parallel, and the part of the first needle body 22 protruding from the valve assembly 100 is smaller than the part of the second needle body 24 protruding from the valve assembly 100.

[0056] In particular, the distance between the free ends of the first needle body 22 and the second needle body 24 needs to be customized according to the specific requirements of the conical bottle, and the adjustable range is 3-12 mm. The distance between the free ends of the first needle body 22 and the second needle body 24 is determined by fluid mechanics simulation and verification, which can ensure that the microspheres in the conical bottom container 231 can be completely delivered into the human body, and is beneficial to simplify the operation steps and reduce the operation time.

[0057] The valve core 30 can be automatically or manually driven to rotate. The infusion system 200 comprises an actuating member coupled to the valve core 30, which is used to drive the valve core 30 to rotate between the first position and the second position. Optionally, the valve core 30 is further provided with a knob 34 located outside the valve body 16. The knob 34 is beneficial to drive the valve core 30 to rotate. As shown in Figure 2 , the knob 34 is configured to have a cylindrical middle part and a one-letter-shaped side. Optionally, the knob 34 is aligned with the partition plate 32, and the position of the knob 34 corresponds to the position of the partition plate 32.

[0058] As shown in Figure 5 , when the valve core 30 is in the first position (i.e., the partition plate 32 is in the horizontal position), the first channel is formed by the isolation of the partition plate 32 and the blocking step 15, the medium in the flow channel flows from the first opening 11 to the second opening 12, and the container 231 is isolated from the flow channel. As shown in Figure 4When the valve core 30 is in the second position (i.e., the partition 32 is in the vertical position), the partition forms the second and third channels, and the container 231 is connected to the flow channel. The medium in the flow channel flows from the first opening 11 to the third opening 13, enters the container 231 through the first needle body 22, mixes with the medium in the container, and then enters the cavity of the valve body 16 through the second needle body 24, flowing from the fourth opening 14 to the second opening 12.

[0059] Figure 6 , Figure 7 Another embodiment of the valve assembly 100 of this disclosure is shown, wherein, with Figure 4 , Figure 5 The valve assembly differs in that valve core 30 is replaced with valve core 40. See details below. Figure 7 The valve core 40 is provided with a valve block 42, and the valve block 42 is provided with a valve core channel 44. When the valve core 40 is in the first position, the first channel is at least partially formed by the valve core channel 44. Specifically, when the cavity is constructed as a cylinder, the valve block 42 is constructed with a cross-sectional shape as shown in the figure. Figure 6 The column shown has two sidewalls with a central recess that are opposite to each other. Specifically, the lateral dimensions of the two sides of the valve block 42 are larger than the lateral dimension of the center of the valve block 42. (See also...) Figure 7 When valve block 42 is in the first position, the lateral dimensions on both sides of valve block 42 are relatively large, which can effectively separate the first opening 11, the second opening 12 from the third opening 13 and the fourth opening 14; see also Figure 6 When the valve block 42 is in the second position, the lateral dimension of the middle part of the valve block 42 is small, which is conducive to the smooth flow of the medium in the second and third channels. Optionally, the valve core 40 is also provided with a knob 46 located on the outside of the valve body 16. Optionally, the knob 46 is aligned with the valve core channel 44, and the position of the knob 46 corresponds to the position of the valve core channel 44.

[0060] In some embodiments, except for the valve core, the first needle body, and the second needle body, the remaining components of the valve assembly 100 are integrally formed. In some embodiments, except for the valve core, the remaining components of the valve assembly 100 are integrally formed.

[0061] In particular, the microspheres are radioactive. See also Figure 9 The infusion system 200 includes a radiation shield 204, within which a container 231 for storing the microspheres is placed. Optionally, the container 231 for storing the microspheres is configured as a transparent V-shaped bottle (conical bottom flask). See also Figure 8 , Figure 9The infusion system 200 further comprises an infusion box 240, the container 231, the radiation-proof device 204 and the valve assembly 100 are arranged in the infusion box 240, and the pipeline 201 and the pipeline 202 connected with the valve assembly 100 extend through the infusion box 240. The infusion box 240 is used for storing the container 231, the radiation-proof device 204 and the pipeline, and all of them are transparent, so that the medical staff can observe the microsphere delivery at any time during the operation.

[0062] Specifically, the infusion box 240 comprises a box cover 241, a bottom plate 246 and a side wall between the box cover 241 and the bottom plate 246. More specifically, the infusion box 240 is configured as a cuboid, and the side wall comprises a first side wall 242, a second side wall 243, a third side wall 244 and a fourth side wall 245. When viewed from above, the first side wall 242, the second side wall 243, the third side wall 244 and the fourth side wall 245 are arranged in an anticlockwise direction. The first side wall 242 is provided with a first hole 2422, and the pipeline 201 extends through the first hole 2422. The third side wall 244 is provided with a third hole 2442, and the pipeline 202 extends through the third hole 2442.

[0063] Continuing to refer to Figure 9 Specifically, to facilitate the operation of the medical staff, the infusion system 200 further comprises a bracket 250 for connecting the valve assembly 100, and the bracket 250 is coupled to the infusion box 240 and can move up and down relative to the infusion box 240. Moving the bracket 250 up and down can drive the valve assembly 100 to move up and down, so that the free ends of the first needle body 22 and the second needle body 24 are above or below the liquid level of the microsphere mixture in the container 231. In some embodiments, the actuating member of the infusion system 200 for operating the valve core 30 is configured as a servo motor coupled to the valve core 30. In other embodiments, the actuating member is configured as an operating rod 260, and operating the operating rod 260 can drive the valve core 30 to rotate between the first position and the second position, so that the container 231 can be selectively communicated with the flow passage.

[0064] Referring to Figure 10 The box cover 241 of the infusion box 240 is provided with a bracket hole 2412, the bracket 250 extends through the bracket hole 2412, and the bracket 250 can be supported in contact with the part of the box cover 241 defining the bracket hole 2412, so that the bracket 250 is kept in a fixed longitudinal position. Specifically, the bracket 250 has a first longitudinal position (see Figure 9 ) and a second longitudinal position (see Figure 13 When the bracket 250 is located in the first longitudinal position or the second longitudinal position, it can be supported by the infusion box 240, so that the bracket 250 is kept in the first or second longitudinal position. Referring to Figure 9When the bracket 250 is in the first longitudinal position, the free ends of the first needle body 22 and the second needle body 24 are both located in the container 231, and the free end of the second needle body 24 is below the liquid level of the container 231; see Figure 13 When the bracket 250 is in the second longitudinal position, the free ends of the first needle body 22 and the second needle body 24 are both located outside the container 231.

[0065] Preferably, the box cover 241 further comprises a protrusion 2414 arranged in the bracket hole 2412, and the bracket 250 at least contacts the upper surface of the protrusion 2414 when the bracket 250 is in the first longitudinal position or the second longitudinal position. Optionally, the bracket hole 2412 is circular in shape. The protrusion 2414 protrudes inward from the hole wall of the bracket hole 2412. Optionally, the protrusion has two mutually perpendicular side walls located in the bracket hole 2412. Optionally, the protrusion 2414 is detachably connected to the box cover 241, facilitating the installation of the bracket 250.

[0066] Specifically, referring to Figure 11 , Specifically, referring to Figure 12 , the bracket 250 comprises a bracket body 251 and a valve connecting portion 252 arranged at one end of the bracket body 251. The valve connecting portion 252 is provided with a receiving groove 2522 for connecting the valve assembly 100. The valve assembly 100 can be placed in the receiving groove 2522, so that the valve assembly 100 can move with the bracket 250. More specifically, the valve connecting portion 252 is provided with two clamping rods 2524 extending in the longitudinal direction and a clamping plate 2526. Among them, the two clamping rods 2524 are located on the same side and are arranged in parallel and spaced apart, and the two clamping rods 2524 and the clamping plate 2526 are oppositely arranged to form the receiving groove 2522. The extension direction of the first tube body 18 and the second tube body 19 of the valve assembly 100 is the same as the extension direction of the receiving groove 2522. The two clamping rods 2524 are arranged in a spaced apart manner, so that the knob 46 of the valve core 40 can extend through the gap between the two clamping rods 2524. The clamping rod 2524 and the clamping plate 2526 are further provided with a limiting protrusion 2528 protruding inward, which is used to prevent the valve assembly 100 from being separated from the valve connecting portion 252. In some embodiments, the limiting protrusion 2528 is detachably connected to the clamping rod 2524 and the clamping plate 2526. When installed, the valve assembly 100 can be placed in the receiving groove 2522, and then the limiting protrusion 2528 is fixed to the clamping rod 2524 and the clamping plate 2526. In another embodiment, the limiting protrusion 2528 is directly formed on the end of the clamping rod 2524 and the clamping plate 2526. When installed, the clamping rod 2524 and the clamping plate 2526 have elasticity, which can push the valve assembly 100 into the receiving groove 2522.

[0067] The bracket main body 251 extends longitudinally and is provided with a receiving portion 2514 extending longitudinally and adapted to receive the cover protrusion 2414. When the receiving portion 2514 is aligned with the protrusion 2414 (i.e. the protrusion 2414 is located in the receiving portion 2514), the bracket main body 251 can be moved longitudinally relative to the infusion box 240 so that the bracket 250 can be moved between the first longitudinal position and the second longitudinal position. The bracket 250 further comprises a hand holding portion 255 provided at an end of the bracket main body 251 away from the valve body connecting portion 252. The hand holding portion 255 not only facilitates the operator to hold the bracket 250, but also provides a limit for the longitudinal movement of the bracket main body 251. In addition, when the bracket 250 is located at the first longitudinal position, the hand holding portion 255 abuts against at least the protrusion 2414 so that the bracket 250 is kept at the first longitudinal position. Specifically, the hand holding portion 255 is configured as a circular flat plate.

[0068] With reference to Figure 11 In addition, the bracket main body 251 is further provided with a combination groove 2512 arranged circumferentially offset from the receiving portion 2514 and in communication with the receiving portion 2514, and the combination groove 2512 is adapted to combine with the protrusion 2414. When the receiving portion 2514 is aligned with the protrusion 2414, the bracket 250 can be moved to the second longitudinal position, and the bracket 250 is rotated so that the protrusion 2414 enters the combination groove 2512. At this time, the upper side wall of the combination groove 2512 is in contact with the upper surface of the protrusion 2414, thereby supporting the bracket 250 so that the bracket 250 is kept at the second longitudinal position. In addition, when the protrusion 2414 is located in the combination groove 2512, the upper and lower side walls of the combination groove 2512 can also limit the longitudinal movement of the bracket 250.

[0069] Specifically, the bracket body 251 is configured to have a cross shape in cross section, i.e., the bracket body 251 includes four plate bodies 2516 arranged along an axis thereof, and the four plate bodies 2516 are arranged at a uniform interval in a circumferential direction. A receiving portion 2514 is formed between two adjacent plate bodies 2516 of the bracket body 251. One side of the bracket body 251 close to the two clamping rods 2524 is provided with a combination groove 2512, and more specifically, a portion of the plate body close to the valve body connecting portion 252 of one of the plate bodies is removed to form the combination groove 2512. Preferably, the bracket 250 further includes a stopper 253 arranged between two adjacent plate bodies 2516 and located at a longitudinal position between the hand-held portion 255 and the valve body connecting portion 252. The stopper 253 is arranged between two plate bodies, so that the bracket 250 can be parked at a third longitudinal position between the first longitudinal position and the second longitudinal position, and the bracket 250 is turned to the corresponding position (i.e., turned to the receiving portion 2514 aligned with the convex portion 2414) to move from the first longitudinal position to the second longitudinal position. Specifically, the stopper 253 and the receiving portion 2514 are arranged on both sides of the plate body provided with the combination groove 2512. The arrangement of the stopper 253 can also enhance the overall strength of the bracket 250. Specifically, the receiving portion 2514 is arranged on only one side of the plate body provided with the combination groove 2512, and the bracket 250 further includes two reinforcing plates 254 arranged between the remaining plate bodies, as shown in Figure 12 .

[0070] Referring to Figure 13 , the convex portion 2414 is located in the combination groove 2512, so that the bracket 250 is kept in the second longitudinal position. At this time, the first needle body 24 is separated from the container 231.

[0071] Referring to Figure 14 , the operating rod 260 includes a rod body 261 and a connecting portion 262 arranged at one end of the rod body 261. The connecting portion 262 is provided with a coupling feature coupled with the knob for combination with the knob 34. Referring to Figure 9 , the connecting portion 262 is located in the infusion box 240; referring to Figure 10 , the second side wall 243 of the infusion box 240 is provided with a second hole 2434, and the rod body 261 can extend through the second hole 2434. The medical staff manually rotates the operating rod 260 to drive the valve core 30 to rotate. Alternatively, the connecting portion 262 cannot pass through the second hole 2434, which can limit the range of movement of the operating rod 260 along its axis. The operating rod 260 is detachably connected to the knob 34.

[0072] Specifically, the coupling feature of the connecting portion 262 is configured as a connecting groove 2622, and the connecting portion 262 is provided with the connecting groove 2622 adapted to accommodate the knob 34 away from one end of the rod body 261. Alternatively, the connecting portion 262 is detachably connected to the rod body 261. Specifically, the rod body 261 is configured as a cylinder, the second hole 2434 is configured as a circular hole, the connecting portion 262 is configured as a cylinder, and the radius of the connecting portion 262 is greater than the radius of the second hole 2434.

[0073] In some embodiments, the operating rod 260 comprises a limiting block 263, and the infusion tank 240 is provided with a limiting groove 2438, and the limiting block 263 is located in the limiting groove 2438 and limits the rotation range of the operating rod 260 when the connecting portion 262 is combined with the knob 34. The limiting groove 2438 can limit the rotation of the operating rod 260 between the first rotation position and the second rotation position, thereby rotating the valve core 30 between the first position and the second position. That is, when the operating rod 260 is located at the first rotation position, the valve core 30 is located at the first position; when the operating rod 260 is located at the second rotation position, the valve core 30 is located at the second position. Preferably, the limiting block 263 is located outside the infusion tank 240, and the limiting groove 2438 can also limit the axial movement of the operating rod 260.

[0074] Specifically, in some embodiments, the second side wall 243 is provided with two stop blocks, and the limiting groove 2438 is formed between the two stop blocks. In some embodiments, the limiting groove 2438 is formed by removing the part of the second side wall 243 adjacent to the second hole 2434. See Figure 10 In some embodiments, the second side wall 243 is provided with a limiting disc 2432, and the second hole 2434 is arranged in the middle of the limiting disc 2432. The limiting disc 2432 located on one side of the outer surface is provided with a limiting groove 2438 in communication with the operating rod hole, and the limiting groove 2438 is defined by two side walls and a bottom wall located between the two side walls. See Figure 10 The limiting disc 3432 is provided with a limiting step 2436 protruding from the outer surface of the second side wall 243, and the limiting groove 2438 in communication with the second hole 2434 is formed between the opposite sides of the limiting step 2436. Alternatively, the limiting step 2436 of the limiting disc 3432 can also be flush with the outer surface of the second side wall 243, or lower than the outer surface of the second side wall 243. When the bottom wall of the limiting groove 2438 is in contact with the limiting block 263, the continued movement of the operating rod 260 towards the valve assembly 100 can be limited. Alternatively, when the connecting portion 262 is combined with the knob 34, the bottom of the limiting groove 2438 is in contact with the limiting block 263.

[0075] Specifically, the operating rod 260 comprises a handle 264 arranged at the other end of the rod body 261. The handle 264 is provided with anti-slip features, so that the operating rod 260 is easy to hold and rotate. Specifically, the anti-slip features are anti-slip stripes arranged circumferentially on the handle. Optionally, the operating rod 260 is further provided with a baffle 265 located at the rod body 261, which facilitates holding and operating. Specifically, the baffle 265 is arranged at one side of the handle 264 close to the connecting portion 262.

[0076] The following will be described in detail in combination with Figure 8 , Figure 9 , Figure 13 , Figure 14 the relevant operation steps of the entire infusion system. After connecting the pipelines, the valve assembly 100 is operated to make the valve core 30 located at the first position, i.e., the state that the needle bodies (the first needle body 22 and the second needle body 24) are communicated with the pipelines. First, the support 250 is controlled to move to the third longitudinal position, so that the free ends (the tip ends) of the first needle body 22 and the second needle body 24 are both located below the liquid level of the container 231 containing the water for injection. According to the operation in the first step described above, the water for injection is injected into the pipelines to remove the air in the pipelines. After the air in the pipelines is removed, the support 250 is controlled to move to the second longitudinal position and to stop at the infusion tank 240. The container 231 containing the radioactive microspheres is placed at the designated position in the infusion tank 240, and the support 250 is controlled to move to the first longitudinal position so that the two needle bodies pierce into the container 231 containing the radioactive microspheres and the second needle body 24 is located below the liquid level of the microsphere mixed solution. At this time, the support 250 stops at the infusion tank 240 and remains at the first longitudinal position. In steps two to four, the water for injection and the contrast agent are intermittently pushed into the pipelines, in step five, the microspheres are continuously injected with air, and in step six, the water for injection is continuously injected. The detailed steps are described above. When the needle bodies need to be communicated with the pipelines, the operating rod 260 is used to rotate the knob 34 to make the valve core 30 located at the first position; when the needle bodies need to be isolated from the pipelines, the operating rod 260 is used to rotate the knob 34 to make the valve core 30 located at the second position. When the microspheres are completely sent into the human body, the pipelines are closed, and the syringe, the pipelines, the valve assembly 100, etc. are placed in the nuclear waste treatment tank.

[0077] In some embodiments, it is not necessary to continuously inject the microspheres with air. When the microspheres are completely sent into the human body using the water for injection, the fifth step can be removed.

[0078] Using the infusion system of the present disclosure, during the infusion process, the longitudinal positions of the two needle bodies do not need to be changed after they pierce into the container 231 containing the radioactive microspheres, and the docking mode of the pipelines does not need to be frequently changed, so the operation is simple and fast. At the same time of reducing the operation time, the risk of radiation to the operator is reduced, and the time of the operator exposed to the radiation environment is also reduced.

[0079] The above merely describes several embodiments of the present disclosure, and those skilled in the art can make various modifications or changes to the embodiments of the present disclosure according to the content disclosed in the application file without departing from the spirit and scope of the present disclosure.

Claims

1. A valve assembly for use in an infusion system, characterized in that, include: The valve body includes a valve body having a cavity and a first opening, a second opening, a third opening, and a fourth opening communicating with the cavity; A valve core is rotatably disposed in the cavity, thereby forming a first channel, a second channel, and a third channel within the valve assembly; A first needle body and a second needle body, wherein the first needle body is connected to the third opening and the second needle body is connected to the fourth opening; When the valve core is in the first position, the first opening and the second opening are connected to form a first channel; When the valve core is in the second position, the first opening and the third opening communicate to form a second channel, and the second opening and the fourth opening communicate to form a third channel.

2. The valve assembly according to claim 1, characterized in that, The valve core is provided with a partition plate, which is rotatably disposed in the cavity; When the valve core is in the first position, the surface of at least one side of the partition defines the first channel.

3. The valve assembly according to claim 2, characterized in that, The valve body is provided with a blocking step located in the cavity. When the valve core is in the first position, the blocking step and the partition together define the first channel.

4. The valve assembly according to claim 3, characterized in that, The cavity is constructed in a columnar shape and is coaxially arranged with the valve core. Two blocking steps are constructed, one of which is located near the first opening and the other is located near the second opening.

5. The valve assembly according to claim 1, characterized in that, The valve core is provided with a partition, and the partition is provided with a valve core channel; When the valve core is in the first position, the first channel is at least partially formed by the valve core channel.

6. The valve assembly according to claim 5, characterized in that, The lateral dimensions on both sides of the valve block are greater than the lateral dimensions in the middle of the valve block.

7. The valve assembly according to any one of claims 1 to 6, characterized in that, The distance from the center of the valve core to the free end of the first needle is greater than the distance from the center of the valve core to the free end of the second needle.

8. The valve assembly according to claim 7, characterized in that, The first needle body and the second needle body are arranged in parallel, and the distance between the free end of the first needle body and the free end of the second needle body is 3 to 12 mm.

9. The valve assembly according to claim 7, characterized in that, The valve body includes a connecting body disposed on the outer periphery of the valve body. The connecting body includes a cone portion. The extension directions of the first needle body and the second needle body are both parallel to the axis of the cone portion, and the first needle body and the second needle body extend through the cone portion. Most of the cone portion is close to the valve body.

10. A radioactive microsphere delivery system, characterized in that, It includes a first pipeline, a second pipeline, a container, and a valve assembly as described in any one of claims 1 to 8; The first opening of the valve assembly is connected to the first pipeline, the second opening of the valve assembly is connected to the second pipeline, and the container is connected to the valve assembly through the first needle and the second needle. When the valve core is in the first position, the container is isolated from the first and second pipelines; when the valve core is in the second position, the container is connected to the first and second pipelines.

11. The infusion system according to claim 10, characterized in that, The infusion system further includes an actuator coupled to the valve core, the actuator being used to drive the valve core to rotate between a first position and a second position.

12. The infusion system according to claim 11, characterized in that, The valve core has a knob located outside the valve body, and the actuator is configured as an operating lever. One end of the operating lever has a coupling feature that is coupled to the knob, and the operating lever is detachably connected to the knob.

13. The infusion system according to claim 10, characterized in that, The infusion system also includes an infusion tank and a support, the container and the valve assembly are located inside the infusion tank, the support is connected to the valve assembly, and the support is coupled to the infusion tank; The support has a first longitudinal position and a second longitudinal position. When the support is in the first longitudinal position, the first needle and the second needle are located inside the container and the second needle is in communication with the microsphere mixture inside the container. When the support is in the second longitudinal position, the first needle and the second needle are located outside the container.

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