Kinesio patch, preparation method thereof and application of kinesio patch in treatment of muscle and bone diseases

Abstract

A preparation method of the kinesiology tape comprises the following steps: uniformly dispersing a nano traditional Chinese medicine tincture into medical acrylic glue to prepare traditional Chinese medicine acrylic glue; the surface of the waterproof elastic cloth is coated with traditional Chinese medicine acrylic glue; covering the surface of the traditional Chinese medicine acrylic adhesive with a back hydrophilic paper protective layer; the preparation method of the nano traditional Chinese medicine tincture comprises the following steps: drying the clove, the safflower, the turmeric, the dandelion, the cinnamon, the pseudo-ginseng and the peach kernel, crushing and mixing; adding 5 times of ethanol, sealing and soaking, filtering and separating; adding ethanol into medicine residues for secondary soaking, filtering and separating; combining the two filtrates, and further filtering; dissolving the borneol and the camphor in ethanol, adding the borneol and the camphor together with the menthol, and fixing the volume with ethanol; performing high-pressure micro-jet circulation treatment on the liquid medicine for multiple times, and supplementing ethanol to fix the volume. The kinesio patch has the basic effects of the kinesio patch, can better exert the effects of promoting blood circulation to remove meridian obstruction and eliminating cold to stop pain of traditional Chinese medicines, and manifests the unique advantage of synergistic treatment of acute and chronic muscle and bone diseases of traditional Chinese medicines and western medicines.

Description

Technical Field

[0001] This invention relates to the field of pharmaceutical preparation technology, and in particular to a kinesiology patch, its preparation method, and its application in the treatment of musculoskeletal disorders. Background Technology

[0002] In the field of modern medicine, nanotechnology, as an emerging technology, is increasingly becoming a hot research area in modern pharmaceutical science. The particle size and size distribution of drug particles are key factors affecting drug pharmacology, efficacy, and performance. High-pressure microfluidic homogenization technology, with its ability to alter drug particle size, primarily relies on processing pressure, cycle number, and the properties of the drug itself to control particle size. High-pressure microfluidic equipment can be used to prepare two dosage forms: nanosuspensions and nanoemulsions. Compared with traditional drug formulations, nanoparticles have significant advantages such as small particle size, large specific surface area, and macroscopic quantum tunneling effects. They can effectively improve the saturated solubility and dissolution rate of drugs, especially poorly soluble drugs, enhance efficacy and targeting, improve bioavailability and absorption stability, while reducing drug dosage and adverse reactions, showing broad application prospects in the pharmaceutical field.

[0003] Kinesio taping (KT), also known as kinesiology tape, is a non-invasive therapeutic technique created in the 1970s by Japanese chiropractor Dr. Kenso Kase to maintain the effects of his manual therapy. Its principle involves applying elastic adhesive tape to the body surface, utilizing biomechanical and physiological effects to protect the musculoskeletal system, promote motor function, or achieve specific therapeutic goals.

[0004] This invention aims to address various acute and chronic musculoskeletal disorders by innovatively combining the advantages of modern rehabilitation therapy techniques like kinesiology patches with traditional Chinese medicine external therapies. Furthermore, it innovatively utilizes high-pressure microfluidic nanotechnology to incorporate traditional Chinese medicine into the medical acrylic adhesive layer of the kinesiology patch, thus creating a modified kinesiology patch. This allows for better integration of the blood-activating, meridian-clearing, cold-dispelling, and pain-relieving effects of traditional Chinese medicine with the kinesiology patch, fully leveraging the unique advantages of traditional Chinese medicine in the synergistic treatment of acute and chronic musculoskeletal disorders. Summary of the Invention

[0005] The purpose of this invention is to address the shortcomings of existing technologies by providing a kinesiology patch, its preparation method, and its application in the treatment of musculoskeletal disorders.

[0006] To achieve the above objectives, the technical solution adopted by the present invention is as follows:

[0007] The first aspect of the present invention is to provide a method for preparing a kinesiology patch, comprising the steps of:

[0008] S1. The nano-sized Chinese medicine tincture is evenly dispersed in medical acrylic glue to obtain the Chinese medicine acrylic glue;

[0009] S2. Coat the surface of the waterproof elastic fabric with the traditional Chinese medicine acrylic adhesive;

[0010] S3. Cover the surface of the Chinese medicine acrylic adhesive with a backing paper protective layer;

[0011] S4. Die-cut and form to obtain the kinesiology tape;

[0012] The preparation steps of the nano-sized traditional Chinese medicine tincture include:

[0013] P1-1. Cloves, safflower, turmeric, dandelion, cinnamon, Panax notoginseng and peach kernel are dried, ground and mixed to obtain the first medicinal mixture;

[0014] P1-2. Add 5 times the amount of ethanol to the first mixture of medicinal materials, seal and soak, then filter to separate the residue from the initial filtrate.

[0015] P1-3. The dregs are soaked in ethanol for a second time, and then filtered to obtain a secondary filtrate.

[0016] P1-4. Combine the initial filtrate and the secondary filtrate, and sequentially perform coarse filtration with gauze and fine filtration with a filter membrane to obtain the initial extract.

[0017] P2. After dissolving borneol and camphor in ethanol, add them together with menthol to the initial extract and make up to volume with ethanol to obtain the extract.

[0018] P3. The drug solution is circulated through a high-pressure microjet several times, and then ethanol is added to make up the volume after treatment.

[0019] P4. Add Tween-80 as a stabilizer, and then filter through a sterile filter membrane and dispense in the dark.

[0020] Preferably, the parameters of the high-pressure microjets include:

[0021] The material reactor is made of diamond.

[0022] The material reactor consists of an interactive cavity and an auxiliary cavity;

[0023] The diameter of the micropores in the interactive cavity is 50μm-100μm;

[0024] The diameter of the micropores in the auxiliary cavity is 100μm-300μm;

[0025] The high-pressure microjet has a processing pressure of 10,000 psi-50,000 psi.

[0026] Preferably, the parameters of the high-pressure microjets include:

[0027] Temperature range: 4℃-25℃;

[0028] The pressure is 1500-1800 bar;

[0029] The loop repeats 3 times.

[0030] Preferably, the raw materials of the nano-Chinese herbal tincture, by weight, include:

[0031]

[0032] A second aspect of the present invention is to provide a kinesiology patch, which is prepared by the preparation method described above, and from the outside to the inside, the kinesiology patch comprises: a waterproof elastic fabric layer, a traditional Chinese medicine acrylic adhesive layer, and a backing paper protective layer.

[0033] A third aspect of the present invention is to provide the application of the kinesiology patch as described above in the preparation of products for treating musculoskeletal disorders, characterized in that the musculoskeletal disorders include: acute or chronic soft tissue injuries, joint pain, muscle strain, or osteoarthritis caused by qi stagnation and blood stasis syndrome or cold-dampness syndrome.

[0034] The present invention adopts the above technical solution and has the following technical effects compared with the prior art:

[0035] (1) This invention innovatively integrates the advantages of modern rehabilitation therapy technology kinesiology patches with traditional Chinese medicine external treatment methods. A nano-sized Chinese medicine tincture is added to the medical acrylic adhesive layer of the kinesiology patch to create a modified kinesiology patch. While possessing the basic effects of kinesiology patches such as pain relief, improved joint mobility, optimized muscle function, enhanced proprioception, improved circulation, and improved movement and posture control, this patch can better leverage the blood-activating, meridian-clearing, cold-dispelling, and pain-relieving effects of traditional Chinese medicine, highlighting the unique advantages of the synergistic treatment of acute and chronic musculoskeletal diseases by traditional Chinese and Western medicine.

[0036] (2) The high-pressure microfluidic nanotechnology used in this invention has significant advantages. The nano-sized drugs processed by this technology have small particle size and large specific surface area, and have macroscopic quantum tunneling effect, which can effectively improve the saturated solubility and dissolution rate of drugs, especially poorly soluble drugs, enhance efficacy and targeting, improve bioavailability and absorption stability, reduce drug dosage, and reduce adverse reactions, thereby more effectively exerting the effects of external treatment of traditional Chinese medicine in promoting blood circulation, relieving pain, and dispelling cold.

[0037] (3) In the current kinesiology patch market and traditional Chinese medicine patch market, this invention successfully pioneered a new sub-category of "functional kinesiology patch," organically integrating a drug delivery system with a physical therapy tool into a single product. This greatly simplifies the process of physical therapy and external application, solving the problem of the two being mutually exclusive. This product is not only suitable for the field of sports injury rehabilitation (the main market for traditional kinesiology patches), but also widely applicable to multiple fields such as chronic musculoskeletal pain, postoperative rehabilitation, and overuse injuries. It possesses a first-mover advantage, differentiated competitiveness, and significant market potential. Attached Figure Description

[0038] Figure 1 This is a schematic diagram of the high-pressure microjet device in this invention. Detailed Implementation

[0039] The specific embodiments of the present invention will be described in detail below.

[0040] Unless otherwise defined, the technical or scientific terms used in the claims and description shall have the ordinary meaning as understood by one of ordinary skill in the art to which this invention pertains.

[0041] The word "comprising" or similar terms used in the specification and claims of this patent application mean that the objects preceding "comprising" include the objects listed after "comprising" or their equivalents, and do not exclude other objects.

[0042] The numerical values ​​mentioned in this invention include all values ​​increasing one unit at a time from low to high, assuming that there is at least a two-unit interval between any lower and higher value. For example, if it is said that a component quantity or a physical quantity is better from 1 to 100, 10 to 90, and 20 to 80, it means that values ​​such as 5 to 95, 14 to 76, 23 to 67, 32 to 58, and 41 to 49 are clearly listed in this specification; for values ​​less than 1, 0.0001, 0.001, 0.01, or 0.1 are considered to be a suitable unit. The foregoing examples are for illustrative purposes only; in practice, all combinations of values ​​between the lowest and highest listed values ​​are considered to be clearly listed in this specification in a similar manner.

[0043] This invention aims to develop a kinesiology patch comprising ten traditional Chinese medicinal herbs: clove, safflower, turmeric, dandelion, cinnamon, notoginseng, peach kernel, menthol, borneol, and camphor. This formula primarily utilizes herbs that are both food and medicine, ensuring good safety. It aims to better leverage the synergistic effects of traditional Chinese medicine in promoting blood circulation, clearing the meridians, dispelling cold, and relieving pain, building upon modern kinesiology patch technology for rehabilitation therapy. The herbal formula is as follows:

[0044] 9g of cloves;

[0045]

[0046] Explanation of Traditional Chinese Medicine Formulas:

[0047] In this formula, cloves and cinnamon warm the meridians, dispel cold, and relieve pain. Cloves, when used externally, utilize their pungent and warm properties to warm the meridians, dispel cold, and promote blood circulation. Cinnamon, when used externally, penetrates deep into the skin, warms the blood and qi, dispels cold and dampness, and promotes blood circulation, thus enhancing the blood-activating effect. At the same time, safflower, turmeric, notoginseng, and peach kernel are used to activate blood circulation, remove blood stasis, and relieve pain. Safflower and peach kernel are a classic pair of herbs for activating blood circulation and removing blood stasis, which can effectively dissipate blood stasis and relieve pain. Turmeric has a particularly strong pungent and warming property, which can penetrate deep into the blood and promote blood circulation in the limbs. Notoginseng, when used externally, can disperse blood stasis, relieve pain, and reduce swelling, making it an essential medicine for traumatic injuries and swelling caused by blood stasis. Dandelion is mainly used for its heat-clearing, detoxifying, swelling-reducing, and nodule-dispersing effects, preventing blood stasis from turning into heat and promoting the dissipation of swelling. Menthol, borneol, and camphor are also natural transdermal absorption enhancers and have cooling and analgesic effects. When used together, these herbs work synergistically to promote blood circulation, clear the meridians, dispel cold, and relieve pain.

[0048] Based on clinical experience, this invention transforms traditional Chinese medicine into a tincture, which also combines with alcohol to enhance the effects of promoting blood circulation, removing blood stasis, reducing inflammation, and relieving pain.

[0049] Preparation method (taking 3000mL as an example): Seven Chinese medicinal herbs (approximately 600g in total): cloves, safflower, turmeric, dandelion, cinnamon, notoginseng, and peach kernel. Dry at 45℃ until the moisture content is no higher than 8%, then pulverize and mix evenly using an ultra-fine pulverizer to obtain the first medicinal mixture. Add five times the amount of 75% ethanol (approximately 2000mL) to the first medicinal mixture, seal and protect from light, and soak for 7 days, stirring twice daily. After 7 days, filter to separate the residue and the initial filtrate. Add 75% ethanol to the residue again for a second soaking for 3 days, then filter to obtain the second filtrate. Combine the initial filtrate and the second filtrate, and sequentially pass through four layers of gauze. The initial extract was prepared by coarse filtration and fine filtration through a 0.45 μm filter membrane. Borneol and camphor were dissolved in 100 mL of ethanol at 50 °C (avoiding open flame), and then added together with menthol to the initial extract. The volume was then adjusted to 3000 mL with 75% ethanol to obtain the final extract. The extract was subjected to high-pressure microfluidic circulation three times (first time at 1500 bar, temperature below 25 °C). After each treatment, ethanol was added to adjust the volume to 3000 mL. 0.1% Tween-80 (3 g) was added as a stabilizer, and the extract was filtered through a 0.22 μm sterile filter membrane and then dispensed into brown glass bottles in the dark. The bottles were sealed and labeled to obtain the final product.

[0050] like Figure 1As shown, the high-pressure microjet device sequentially includes: a feed tank (for traditional Chinese medicine liquid), a one-way valve, a hydraulic pump, a booster, a pressure gauge, an interactive chamber, an auxiliary chamber, a reflux filter, a heat exchanger, and a discharge port (for nano-sized traditional Chinese medicine preparations). The interactive chamber and the auxiliary chamber constitute the material reactor, playing a crucial role in material pulverization. The material reactor is made of diamond, which is hard, wear-resistant, and corrosion-resistant, making it suitable for high-hardness drugs. The booster plunger in the hydraulic pump is made of zirconia ceramic, which is wear-resistant, corrosion-resistant, and does not easily generate static electricity. The high-pressure microjet device can process pressures up to 30,000 psi, resulting in a very stable process flow.

[0051] Employing the principle of airflow pulverization, a hydraulic pump generates high pressure in the fluid, which in turn drives a piston-equipped intensifier. This hydraulically driven intensifier pushes the piston within the intensifier, creating an alternating suction effect that accelerates the fluid. The fluid then enters the interlocking chamber at high speed through micropores (75μm) within the interlocking chamber. There, the fluid is dispersed into two streams, undergoing intense high-speed impact and shearing before entering the auxiliary chamber (200μm). During the impact, most of its energy is instantly converted, generating a significant pressure drop. This process combines high-speed impact, high shear force, cavitation, and high-frequency vibration to pulverize the medicinal materials, reducing the droplet or crystal size. Compared to traditional Chinese medicine external application patches, nano-sized drugs possess characteristics such as small particle size, large specific surface area, and macroscopic quantum tunneling effect. This effectively increases the saturated solubility and dissolution rate of Chinese medicine, enhances efficacy and targeting, improves the bioavailability and absorption stability of the application patch, reduces drug dosage, and minimizes adverse reactions.

[0052] The kinesiology patch consists of three layers. The first layer is a waterproof elastic fabric layer; the second layer is a medical-grade acrylic adhesive layer with a "water ripple" pattern, giving it a tensile strength exceeding 40% of its own weight; and the third layer is a protective gel backing paper, facilitating contamination isolation, patch removal, and handling. After successful preparation of a nano-herbal tincture, it is added to the second medical-grade acrylic adhesive layer, working synergistically with the tensile strength of the "water ripple" patterned patch.

[0053] The kinesiology patch is sealed in its outer packaging to prevent air from entering; the bag is neatly sealed, without any tears or odors, and the tear is clean and accurately positioned; the text and patterns are clearly printed and do not peel off; it is easy to store, convenient to carry, and simple and inexpensive to use.

[0054] Kinesiology tape body: clean surface, free of dirt, neat die-cut position, uniform thickness, firm and undamaged, even material distribution, no extra material on the edge sealing, and the printed pattern does not fade.

[0055] Safety: Non-toxic, harmless, and showed no significant irritation in skin irritation tests.

[0056] Microbiological indicators: Total bacterial count <1000 CFU / g, thermotolerant coliforms, Pseudomonas aeruginosa, and Staphylococcus aureus must not be detected, and total mold and yeast count <100 CFU / g.

[0057] For various musculoskeletal disorders, kinesiology patches can be combined with traditional Chinese medicine to promote blood circulation, relieve pain, and alleviate pain, in addition to their effects of reducing pain, improving joint mobility, improving muscle function, enhancing proprioception, promoting circulation, and improving movement and posture control.

[0058] This invention also provides a method for using the kinesiology patch as described above, taking lower back pain as an example. The steps include:

[0059] Step 1: Muscle taping and sensory input taping: To guide and improve sensory input, a "Y"-shaped tape is anchored to the sacrum, with the lumbar spine in a forward flexion position, extending towards the neck; then several "Y"-shaped tapes are stacked layer by layer along the way.

[0060] Step 2: Apply spatial taping to the painful area: In a natural position, use multiple "I"-shaped tapes, covering the pain point in the middle, and apply 20%-30% tension to the entire area. The first two tapes are applied at right angles, and the last two tapes are applied to the affected area in a cross shape at equal angles (replace every 2 days).

[0061] To observe the effects of traditional Chinese medicine fumigation combined with kinesiology patches on limb pain, swelling, and functional recovery in patients with stage I shoulder-hand syndrome after stroke, 120 inpatients with stage I shoulder-hand syndrome after stroke admitted to Zhejiang Rehabilitation Medical Center from January 2021 to December 2022 were selected as the study subjects and randomly divided into a control group, a kinesiology patch group, a traditional Chinese medicine fumigation group, and a combined group, with 30 patients in each group. The control group received routine rehabilitation treatment, the kinesiology patch group received kinesiology patch treatment, the traditional Chinese medicine fumigation group received fumigation treatment with a famous prescription (Astragalus membranaceus and Lycopodium clavatum 30g each, Angelica sinensis, Carthamus tinctorius, and Spatholobus suberectus 15g each, and Ligusticum chuanxiong, Paeonia lactiflora, Cinnamomum cassia, Clematis chinensis, and Commiphora myrrha 10g each), and the combined group received comprehensive treatment of traditional Chinese medicine fumigation and kinesiology patches. The differences in pain scores of the affected upper limb, degree of hand swelling, upper limb Fugl-Meyer motor score, and activities of daily living scores of the four groups before and after treatment were compared.

[0062] Results: Compared with pre-treatment levels, all four groups showed a decrease in affected upper limb pain scores and hand swelling, and an increase in Fugl-Meyer motor scores and activities of daily living scores, with statistically significant differences (P<0.05). The differences in affected upper limb pain scores, hand swelling, Fugl-Meyer motor scores, and activities of daily living scores before and after treatment were all statistically significant among the four groups (F=32.910, 21.087, 42.076, 20.763, P<0.001). The degree of improvement in affected upper limb pain scores and activities of daily living scores was: combined group > traditional Chinese medicine fumigation group > kinesiology patch group > control group. The degree of reduction in hand swelling and the degree of improvement in Fugl-Meyer motor scores were: combined group > kinesiology patch group > traditional Chinese medicine fumigation group > control group.

[0063] Conclusion: Traditional Chinese medicine fumigation combined with kinesiology patches can effectively reduce the pain and swelling of the affected upper limb in patients with stage I shoulder-hand syndrome after stroke and promote the recovery of upper limb function.

[0064]

[0065]

[0066] To observe the clinical efficacy of traditional Chinese medicine (TCM) kinesio taping on knee osteoarthritis in elderly patients. Methods: Ninety-nine patients with knee osteoarthritis (KOA) admitted between February 2021 and March 2022 were recruited and randomly divided into three groups: a kinesio taping (KT) group, a KT + plaster group (the plaster is a classic TCM formula from Professor Zheng Huaixian of Chengdu Sport University, composed of artificial musk, cinnamon, cloves, safflower, sandalwood, etc.), and a TCM kinesio taping group. The KT group received kinesio taping alone; the KT + plaster group received kinesio taping combined with the TCM kinesio plaster; and the TCM kinesio taping group received only TCM kinesio taping. The three groups underwent pain visual analogue scale (VAS) assessment, proprioceptive assessment [active angel repositioning (AAR) and passive motion threshold (TDPM)], Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) visual scale, musculoskeletal ultrasound parameters (maximum effusion depth, Szkudlarek synovial grade), and laboratory tests [tumor necrosis factor-α (TNF-α), matrix metalloproteinase-9 (MMP-9), osteoprotegerin (OPG), and chemokine 12 (CXCL12) in synovial fluid] before and after treatment.

[0067] Results: (1) Comparison of VAS score, proprioceptive assessment and WOMAC scale: The trauma KT group had lower VAS score and proprioceptive assessment (AAR, TDPM) than the KT group (P<0.05), but there was no statistically significant difference between the trauma KT group and the KT+plaster group (P>0.05); while in the WOMAC scale, the trauma KT group had lower scores in "pain" and "daily activities" than the other two groups, and only lower scores in "stiffness" than the KT group, with no difference between the trauma KT group and the KT+plaster group. (2) Comparison of musculoskeletal ultrasound indicators: The trauma KT group had lower scores in maximum effusion depth and Szkudlarek grade of synovium than the other two groups (P<0.05). (3) Comparison of laboratory indicators: The trauma KT group had lower levels of TNF-α, MMP-9 and CXCL12 than the other two groups (P<0.05), while the trauma KT group had higher levels of OPG than the KT group, with no statistically significant difference between the trauma KT group and the KT+plaster group (P>0.05).

[0068] Conclusion: Traditional Chinese medicine traumatic kinesiology patch can effectively inhibit symptoms such as pain, swelling, and limited movement in elderly patients with KOA, and improve synovial hyperplasia and multiple laboratory indicators. Its effect is better than that of kinesiology patch alone and the combination of kinesiology patch and traumatic analgesic plaster.

[0069]

[0070]

[0071]

[0072] Note: Compared with before treatment, a P<0.05; compared with the KT group, b P<0.05; compared with the KT+plaster group, c P<0.05.

[0073] To investigate the efficacy of traditional Chinese medicine (TCM) wax therapy combined with kinesiology patch therapy in treating spastic diplegia with cerebral palsy. Methods: 92 children with spastic diplegia with cerebral palsy were randomly divided into three groups: a TCM wax therapy group (prescription: Rehmannia glutinosa 30g, Spatholobus suberectus 20g, Clematis chinensis 20g, Lycopodium clavatum 20g, Piper kadsura 20g, Chaenomeles speciosa 15g, Erythrina variegata 15g, Saposhnikovia divaricata 10g) group (n=31), a kinesiology patch group (n=31), and a combined TCM wax therapy and kinesiology patch group (n=30). All groups received routine rehabilitation treatment, including acupuncture, motor therapy, and massage. Children in the TCM wax therapy group received additional TCM wax therapy, children in the kinesiology patch group received additional kinesiology patch therapy, and children in the combined group received both TCM wax therapy and kinesiology patch therapy. The treatment course for all groups was 6 months. The modified Ashworth Spasticity Rating Scale (MARS), Gross Motor Function Scale 88-item Standing and Standing (GMFM-D) scores, and Walking and Running and Jumping (GMFM-E) scores of the children in each group were compared before and after treatment, and the therapeutic effect was evaluated.

[0074] Results: One patient in each of the herbal wax therapy group and the kinesiology patch group fell off. The combined therapy group showed better results in improving muscle tone and gross motor function than the herbal wax therapy group and the kinesiology patch group (P<0.05); there were no statistically significant differences in the effects of improving muscle tone and gross motor function between the herbal wax therapy group and the kinesiology patch group (P>0.05). After treatment, the Ashworth scores of all three groups of children were lower than before treatment, while the GMFM-D and GMFM-E scores were higher than before treatment, with statistically significant differences (P<0.05). After treatment, the Ashworth scores of the combined treatment group were lower than those of the traditional Chinese medicine wax therapy group and the kinesiology patch group, while the GMFM-D and GMFM-E scores were higher than those of the traditional Chinese medicine wax therapy group and the kinesiology patch group, with statistically significant differences (P<0.05). There were no statistically significant differences in Ashworth scores, GMFM-D scores, and GMFM-E scores between the traditional Chinese medicine wax therapy group and the kinesiology patch group after treatment (P>0.05).

[0075] Conclusion: Traditional Chinese medicine wax therapy combined with kinesiology patches can effectively relieve spasticity, reduce muscle tone, and improve abnormal posture, thereby improving motor dysfunction in children with spastic diplegia and cerebral palsy.

[0076]

[0077] To observe the clinical efficacy of kinesiology patch combined with traditional Chinese medicine (TCM) sitz bath in the treatment of myofascitis. Methods: Sixty patients with myofascitis were randomly divided into a control group and an observation group, with 30 patients in each group. The control group received TCM sitz bath treatment (prescription: Angelica pubescens 15g, Notopterygium incisum 15g, Saposhnikovia divaricata 15g, Asarum heterotropoides 5g, Clematis chinensis 15g), while the observation group received TCM sitz bath combined with a modified self-made kinesiology patch. The improvement in visual analog scale (VAS) scores and clinical efficacy were compared between the two groups.

[0078] Results: After treatment, the VAS score of the observation group was lower than that of the control group (P<0.05), and the total effective rate was higher than that of the control group (P<0.05).

[0079] Conclusion: Kinesiology patch combined with traditional Chinese medicine soaking therapy can significantly control the pain level of patients with myofascitis and improve VAS scores.

[0080]

[0081] Note: Compared with the group before treatment, △P<0.05; compared with the control group after treatment, ▲P<0.05.

[0082] To investigate the effects of acupoint hot compress combined with auricular acupressure on postoperative swelling and pain in patients with limb fractures. Methods: 228 patients with limb fractures admitted to our hospital from January 2018 to May 2020 were selected and divided into a control group and an observation group according to comparability in terms of gender, age, fracture location, cause of fracture, degree of swelling of the affected limb before intervention, and VAS score before intervention, with 114 patients in each group. The control group received routine nursing care and auricular acupressure, while the observation group received the same treatment as the control group, plus a traditional Chinese medicine (prescription: frankincense and myrrh 5g each, turmeric, eupatorium, and drynaria 9g each, pinellia, cyperus, and cinnamon twig 10g each, and gardenia 15g) hot compress combined with kinesiology patch. The swelling degree grading and limb pain assessment results were compared between the two groups.

[0083] Results: The proportion of patients with grade II and III limb swelling in the observation group was 47.37%, which was significantly lower than 61.40% in the control group; the proportion of patients with moderate to severe pain in the affected limb in the observation group was 56.14%, which was significantly lower than 70.18% in the control group; the differences between the groups were statistically significant (P<0.05).

[0084] Conclusion: The application of acupoint hot compress combined with kinesiology tape in patients with limb fractures can effectively relieve postoperative swelling and pain and promote postoperative recovery.

[0085]

[0086]

[0087] χ 2 =4.526, P=0.033.

[0088]

[0089] χ 2 =4.526, P=0.033.

[0090] To observe the clinical efficacy of kinesiology patch combined with traditional Chinese medicine fumigation in the treatment of stenosing tenosynovitis of the radial styloid process. Methods: 120 patients with stenosing tenosynovitis of the radial styloid process were randomly divided into a conventional group, a traditional Chinese medicine group, and an observation group, with 40 patients in each group. The conventional group received topical diclofenac diethylamine latex, while the traditional Chinese medicine group received topical diclofenac diethylamine latex combined with fumigation using traditional Chinese medicine (prescription: 30g of Clematis chinensis, 15g each of Angelica sinensis tail, Carthamus tinctorius, Sappanwood, Angelica dahurica, Curcuma longa, Clematis chinensis, Notopterygium incisum, Acanthopanax senticosus, Erythrina variegata, Achyranthes bidentata, Melia toosendan, and Smilax glabra, 9g of Zanthoxylum bungeanum, and 6g of Boswellia carterii). The observation group received kinesiology patch treatment in addition to the traditional Chinese medicine treatment. The clinical efficacy of the three groups was compared and analyzed. Changes in visual analog scale (VAS) scores, ulnar deviation of the wrist joint, and Cooney score of wrist function before and after treatment were observed. Adverse reactions and recurrence were recorded.

[0091] Results: The total effective rates of the conventional group, the traditional Chinese medicine group, and the observation group were 70.0%, 82.5%, and 97.5%, respectively. The efficacy of the observation group was superior to that of the traditional Chinese medicine group and the conventional group (P<0.05). After treatment, the VAS scores of all three groups decreased compared with those before treatment (P<0.05); the VAS scores of the observation group were lower than those of the traditional Chinese medicine group and the conventional group (P<0.05). After treatment, the ulnar deviation range of the wrist joint increased in all three groups compared with those before treatment, and the Cooney scores increased significantly (P<0.05). The ulnar deviation range of the wrist joint in the observation group was greater than that in the traditional Chinese medicine group and the conventional group, and the Cooney scores were also higher in the observation group than in the traditional Chinese medicine group and the conventional group (P<0.05). The ulnar deviation range of the wrist joint in the traditional Chinese medicine group was greater than that in the conventional group, and the Cooney score was also higher in the traditional Chinese medicine group than in the conventional group (P<0.05). During the 6-month follow-up, the recurrence rate of the observation group was lower than that of the traditional Chinese medicine group and the conventional group (P<0.05).

[0092] Conclusion: Kinesiology tape combined with traditional Chinese medicine fumigation can increase wrist joint range of motion, relieve pain, and reduce recurrence rate. It is a simple, safe and effective treatment method.

[0093]

[0094]

[0095] Note: Compared with the conventional group, ① P<0.05; compared with the traditional Chinese medicine group, ② P<0.05.

[0096] To investigate the efficacy of traditional Chinese medicine (TCM) poultice, acupuncture, and kinesiology patch in the treatment of lateral epicondylitis of the humerus. Methods: Forty patients with lateral epicondylitis of the humerus were randomly divided into a control group and a treatment group, with 20 patients in each group. The control group received TCM (prescription: *Shenjincao*, *Tougucao*, frankincense, *Chuanwu*, myrrh, *Sangjisheng*, *Jixueteng*, *Niuxi*, *Chuanxiong*, *Baizhi*, safflower, *Duzhong*, *Caesalpinia sappan*, *Aiye*, *Caowu*, and licorice).

[0097] The treatment group received herbal poultices and acupuncture, while the treatment group received kinesiology patch therapy in addition to herbal poultices and acupuncture. The treatment effects were compared between the two groups after treatment.

[0098] Results: The total effective rate in the treatment group (100%) was higher than that in the control group (90%), and the difference was statistically significant (P<0.05).

[0099] Conclusion: The combination of traditional Chinese medicine poultices, acupuncture, and kinesiology patches can effectively relieve pain in patients with lateral epicondylitis of the humerus.

[0100]

[0101] Note: Compared with the control group, a P<0.05.

[0102] To investigate the efficacy of traditional Chinese medicine fumigation combined with kinesiology patch therapy in the treatment of lateral epicondylitis of the humerus. Methods: Forty patients with lateral epicondylitis of the humerus were randomly divided into a control group and a treatment group, with 20 patients in each group. The control group received fumigation with traditional Chinese medicine (prescription: Codonopsis pilosula, Astragalus membranaceus, Angelica sinensis 30g each; Prunus persica, Carthamus tinctorius 10g each; Achyranthes bidentata, Angelica pubescens 20g each; Clematis chinensis 15g; Taxillus chinensis, Dipsacus asper 20g each; Citrus reticulata peel, Aucklandia lappa, Spatholobus suberectus 15g each; Lycopodium clavatum 20g). The treatment group received kinesiology patch therapy in addition to the treatment given to the control group.

[0103] Results: The treatment group showed better improvement in VAS score, painless grip strength, and ADL score than the control group (P<0.05).

[0104] Conclusion: The combination of traditional Chinese medicine fumigation and kinesiology patch treatment for lateral epicondylitis of the humerus can effectively relieve pain and improve patients' daily activity ability.

[0105]

[0106] Note: Compared with pre-treatment levels, *P<0.05, **P<0.01; compared with the control group, △P<0.05; VAS: Visual Analogue Scale for Pain.

[0107] The kinesiology patch of this invention is mainly used in the fields of chronic musculoskeletal pain, sports injuries, postoperative rehabilitation, and overuse diseases. It can be used to treat acute or old soft tissue injuries, joint pain, muscle strain, osteoarthritis and other diseases with syndrome differentiation of qi stagnation and blood stasis syndrome or cold-dampness syndrome.

[0108] The above description is merely a preferred embodiment of the present invention and does not limit the implementation and protection scope of the present invention. Those skilled in the art should realize that any equivalent substitutions and obvious changes made based on the description and illustrations of the present invention should be included within the protection scope of the present invention.

Claims

1. A method for preparing a kinesiology patch, characterized in that the steps include... include: S1. The nano-sized Chinese medicine tincture is evenly dispersed in medical acrylic glue to obtain the Chinese medicine acrylic glue; S2. Coat the surface of the waterproof elastic fabric with the traditional Chinese medicine acrylic adhesive; S3. Cover the surface of the Chinese medicine acrylic adhesive with a backing paper protective layer; S4. Die-cut and form to obtain the kinesiology tape; The preparation steps of the nano-sized traditional Chinese medicine tincture include: P1-1. Cloves, safflower, turmeric, dandelion, cinnamon, Panax notoginseng and peach kernel are dried, ground and mixed to obtain the first medicinal mixture; P1-2. Add 5 times the amount of ethanol to the first mixture of medicinal materials, seal and soak, then filter to separate the residue from the initial filtrate. P1-3. The dregs are soaked in ethanol for a second time, and then filtered to obtain a secondary filtrate. P1-4. Combine the initial filtrate and the secondary filtrate, and sequentially perform coarse filtration with gauze and fine filtration with a filter membrane to obtain the initial extract. P2. After dissolving borneol and camphor in ethanol, add them together with menthol to the initial extract and make up to volume with ethanol to obtain the extract. P3. The drug solution is circulated through a high-pressure microjet several times, and then ethanol is added to make up the volume after treatment. P4. Add Tween-80 as a stabilizer, and then filter through a sterile filter membrane and dispense in the dark.

2. The preparation method according to claim 1, characterized in that, The parameters of the high-pressure microjet include: the material reactor is made of diamond; The material reactor consists of an interactive cavity and an auxiliary cavity; The diameter of the micropores in the interactive cavity is 50μm-100μm; The diameter of the micropores in the auxiliary cavity is 100μm-300μm.

3. The preparation method according to claim 1 or 2, characterized in that, The parameters of the high-pressure microjets include: Temperature range: 4℃-25℃; The pressure is 1500-1800 bar; The loop repeats 3 times.

4. The preparation method according to claim 1, characterized in that, The raw materials of the nano-Chinese herbal tincture, by weight, include:

5. A kinesiology patch, prepared by the method described in any one of claims 1-4, characterized in that, From the outside in, the kinesiology patch comprises, in sequence: a waterproof elastic fabric layer, a traditional Chinese medicine acrylic adhesive layer, and a backing paper protective layer.

6. The application of the kinesiology patch as described in claim 5 in the preparation of products for treating musculoskeletal disorders, characterized in that, The aforementioned musculoskeletal disorders include: acute or chronic soft tissue injuries, joint pain, muscle strain, or osteoarthritis caused by qi stagnation and blood stasis syndrome or cold-dampness syndrome.

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