Preparation process and application of lipid hydrocolloid silver sulfate acetate fiber dressing

Abstract

The invention discloses a preparation process and application of a lipid hydrocolloid silver sulfate acetate fiber dressing, and the preparation process comprises the following steps: sequentially adding thermoplastic rubber, liquid paraffin, tackifying resin, an antioxidant and a plasticizer into a kneading machine, stirring and mixing, then adding sodium carboxymethyl cellulose and silver sulfate, continuously stirring to uniformly mix, and thus obtaining the lipid hydrocolloid silver sulfate acetate fiber dressing. The preparation method comprises the following steps: preparing a hollow reticular cellulose acetate fiber spunlace non-woven fabric, adding medical vaseline, simethicone, liquid paraffin and citric acid to obtain a mixture, uniformly coating the hollow reticular cellulose acetate fiber spunlace non-woven fabric with the obtained mixture by adopting an extruder, cutting the hollow reticular cellulose acetate fiber spunlace non-woven fabric into a required shape, packaging, and carrying out radiation crosslinking to obtain the lipid hydrocolloid silver sulfate cellulose acetate fiber dressing. When the prepared dressing is used, a healing microenvironment with certain humidity and an antibacterial effect is provided, and the dressing is not adhered to the surface of a wound and peripheral skin, so that the dressing is free of pain and bleeding when being replaced, is particularly soft and easy to curl, and has relatively good compliance to the wound which is difficult to fix, and the antibacterial property of the dressing is further improved.

Description

Technical Field

[0001] This invention belongs to the field of biomedical materials technology, specifically relating to the preparation process and application of a lipid hydrocolloid silver sulfate cellulose acetate dressing. Background Technology

[0002] The skin is the largest organ in the human body and plays an important role in resisting the invasion of external microorganisms, excreting waste and preventing water evaporation, regulating body temperature, and maintaining the stability of the internal environment. Therefore, when the skin is injured, it is necessary to actively repair the wound and promote wound healing in order to avoid further deterioration. Functional dressings are one of the most commonly used wound care products.

[0003] Currently, the main types of dressings used in clinical practice are: traditional gauze dressings, mesh dressings, and antibacterial dressings. However, these three types of dressings cannot simultaneously solve problems such as complete breathability of the wound, absorption of exudate, scarring, and antibacterial properties. Summary of the Invention

[0004] To address the shortcomings of existing technologies, the present invention aims to provide a preparation process and application of a lipid hydrocolloid silver sulfate cellulose acetate dressing.

[0005] To achieve the above objectives, the present invention adopts the following technical solution: A process for preparing a lipid hydrocolloid silver sulfate cellulose acetate dressing includes the following steps: Step S1: Add thermoplastic rubber, liquid paraffin, tackifying resin, antioxidant, and... Plasticizers were added sequentially to a kneader and stirred under heating conditions to mix them evenly, resulting in mixture 1; Step S2: Add sodium carboxymethyl cellulose and silver sulfate to mixture 1 obtained in step S1, and continue stirring under heating conditions to mix them evenly to obtain mixture 2. Step S3: Heat the medical petroleum jelly to 60°C and set aside. Step S4: Mix dimethyl silicone oil, liquid paraffin and citric acid in a certain weight ratio to obtain mixture 3; Step S5: Mix the medical petroleum jelly heated to 60°C in step S3 with the mixture 3 obtained in step S4, cool to room temperature to obtain mixture 4, add the mixture 4 obtained in step S2 to mixture 2, stir and mix evenly to obtain hydrocolloid cream. Step S6: The hydrocolloid cream obtained in step S5 is evenly coated onto a hollow mesh cellulose acetate spunlace nonwoven fabric using an extruder, pressed tightly, covered with a polyester release film, and finally cut into the required shape, packaged, and subjected to radiation crosslinking to obtain a lipid hydrocolloid silver sulfate cellulose acetate dressing.

[0006] Preferably, the thermoplastic rubber in step S1 is any one of SBS, SEBS, TPU and ethylene-propylene rubber; the tackifying resin is any one of petroleum resin, rosin glyceride and gum rosin; the antioxidant is any one of 2,6-di-tert-butyl phenol, 2,5-di-tert-butyl quinoline and 2,6-di-tert-butyl-4-methyl phenol; and the plasticizer is any one of dioctyl adipate, dioctyl phthalate and dibutyl phthalate.

[0007] Preferably, the weight ratio of the thermoplastic rubber, liquid paraffin, tackifying resin, antioxidant and plasticizer in step S1 is 40:25:5:5:1.

[0008] Preferably, the heating temperature in step S1 is 70-120°C, the stirring speed is 40-60 r / min and the stirring time is 2.5-4 h.

[0009] Preferably, the weight ratio of mixture 1, sodium carboxymethyl cellulose and silver sulfate in step S2 is 35:10:3.

[0010] Preferably, the heating temperature in step S2 is 70-120°C, the stirring speed is 50-80 r / min and the stirring time is 3-6 h.

[0011] Preferably, the weight ratio of dimethyl silicone oil, liquid paraffin and citric acid in step S4 is 12.5:10:1.

[0012] Preferably, the weight ratio of medical vaseline to mixture 3 in step S5 is 1:1.

[0013] The weight ratio of mixture 4 to mixture 2 in step S5 is 8:1.

[0014] Preferably, a lipid hydrocolloid silver sulfate acetate fiber dressing is prepared by the above preparation process of the lipid hydrocolloid silver sulfate acetate fiber dressing.

[0015] Preferably, the above lipid hydrocolloid silver sulfate acetate fiber dressing is used for delivering drugs.

[0016] Compared with the prior art, the present application has the following positive and beneficial effects: The application takes hollow reticular acetic acid fiber as a dressing base material, and a mixture of thermoplastic rubber, liquid paraffin, tackifying resin, antioxidant and plasticizer is reacted with silver sulfate lipid hydrocolloid and slurry to form a silver sulfate lipid hydrocolloid acetic acid fiber dressing, which contains silver sulfate and can release silver ions to inhibit bacteria, thereby reducing the risk of wound infection. In addition, the lipid hydrocolloid component can keep the wound moist and promote wound healing. The moist environment can also reduce wound dryness and scabbing, reduce pain, and promote the growth and migration of new cells. At the same time, it does not stick to the wound surface and surrounding skin, so that the dressing can be replaced without pain, bleeding or damage to the external tissue. Moreover, the application uses hollow acetic acid fiber non-woven fabric, which has good mechanical strength and elasticity, thereby improving the mechanical strength and elasticity of the dressing, ensuring that the dressing is particularly soft and easy to deform, has good compliance for wounds that are difficult to fix, and further improves the antibacterial performance of the dressing. DETAILED DESCRIPTION

[0017] The technical solutions of the application will be further specifically described through examples, which are for the description of the application and are not a limitation of the application. Based on the examples in the application, all other examples obtained by those skilled in the art without creative labor are within the scope of protection of the application.

[0018] In the examples, the experimental methods are conventional methods unless otherwise specified, and the reagents and materials can be obtained from commercial channels unless otherwise specified.

[0019] Example 1 A preparation process of a silver sulfate lipid hydrocolloid acetic acid fiber dressing includes the following steps: Step S1, SBS, liquid paraffin, petroleum resin, antioxidant 2, 6-di-tert-butyl phenol and plasticizer dioctyl adipate with a weight ratio of 40:25:5:5:1 are sequentially added to a kneader, and stirred at 70°C and 40r / min for 4h to make them uniformly mixed to obtain a mixture 1; Step S2, carboxymethyl cellulose sodium and silver sulfate are added to the mixture 1 obtained in step S1, and continue to be stirred at 70°C and 50r / min for 6h to make them uniformly mixed to obtain a mixture 2, wherein the weight ratio of the mixture 1, carboxymethyl cellulose sodium and silver sulfate is 35:10:3; Step S3, medical vaseline is heated to 60°C for standby; Step S4, dimethyl silicone oil, liquid paraffin and citric acid are mixed according to a weight ratio of 12.5:10:1 to obtain a mixture 3; Step S5: Mix the medical petroleum jelly heated to 60°C in step S3 with the mixture 3 obtained in step S4, cool to room temperature to obtain mixture 4, add the mixture 4 to the mixture 2 obtained in step S2, stir and mix evenly to obtain a hydrocolloid cream, wherein the weight ratio of medical petroleum jelly to mixture 3 is 1:1; the weight ratio of mixture 4 to mixture 2 is 8:1. Step S6: The hydrocolloid cream obtained in step S5 is evenly coated onto a hollow mesh cellulose acetate spunlace nonwoven fabric using an extruder, pressed tightly, covered with a polyester release film, and finally cut into the required shape, packaged, and subjected to radiation crosslinking to obtain a lipid hydrocolloid silver sulfate cellulose acetate dressing.

[0020] Example 2 A process for preparing a lipid hydrocolloid silver sulfate cellulose acetate dressing includes the following steps: Step S1: SEBS, liquid paraffin, rosin glycerol ester, antioxidant 2,5-di-tert-butylquinoline and plasticizer dioctyl phthalate in a weight ratio of 40:25:5:5:1 are added to a kneader in sequence and stirred at 90°C and 50 r / min for 3 hours to make them evenly mixed, to obtain mixture 1. Step S2: Add sodium carboxymethyl cellulose and silver sulfate to mixture 1 obtained in step S1, and continue stirring at 90°C and 65 r / min for 4 hours to make it uniformly mixed, to obtain mixture 2, wherein the weight ratio of mixture 1, sodium carboxymethyl cellulose and silver sulfate is 35:10:3. Step S3: Heat the medical petroleum jelly to 60°C and set aside. Step S4: Mix dimethyl silicone oil, liquid paraffin and citric acid in a weight ratio of 12.5:10:1 to obtain mixture 3; Step S5: Mix the medical petroleum jelly heated to 60°C in step S3 with the mixture 3 obtained in step S4, cool to room temperature to obtain mixture 4, add the mixture 4 to the mixture 2 obtained in step S2, stir and mix evenly to obtain a hydrocolloid cream, wherein the weight ratio of medical petroleum jelly to mixture 3 is 1:1; the weight ratio of mixture 4 to mixture 2 is 8:1. Step S6: The hydrocolloid cream obtained in step S5 is evenly coated onto a hollow mesh cellulose acetate spunlace nonwoven fabric using an extruder, pressed tightly, covered with a polyester release film, and finally cut into the required shape, packaged, and subjected to radiation crosslinking to obtain a lipid hydrocolloid silver sulfate cellulose acetate dressing.

[0021] Example 3 A process for preparing a lipid hydrocolloid silver sulfate cellulose acetate dressing includes the following steps: Step S1, add ethylene-propylene rubber, liquid paraffin, gum rosin, antioxidant 2,6-di-tert-butyl-4-methylphenol and plasticizer dibutyl phthalate in a weight ratio of 40:25:5:5:1 into a kneader in sequence, stir for 2.5 h at 120°C and 60 r / min to make them uniformly mixed to obtain mixture 1; Step S2, add sodium carboxymethyl cellulose and silver sulfate into the mixture 1 obtained in step S1, continue to stir for 3 h at 120°C and 80 r / min to make them uniformly mixed to obtain mixture 2, wherein the weight ratio of mixture 1, sodium carboxymethyl cellulose and silver sulfate is 35:10:3; Step S3, heat medical vaseline to 60°C for standby; Step S4, mix dimethyl silicone oil, liquid paraffin and citric acid according to a weight ratio of 12.5:10:1 to obtain mixture 3; Step S5, mix the medical vaseline heated to 60°C in step S3 with the mixture 3 obtained in step S4, cool to room temperature to obtain mixture 4, add the mixture 4 obtained to the mixture 2 obtained in step S2, stir to mix uniformly to obtain hydrocolloid cream, wherein the weight ratio of medical vaseline to mixture 3 is 1:1; the weight ratio of mixture 4 to mixture 2 is 8:1; Step S6, uniformly coat the hydrocolloid cream obtained in step S5 on hollow reticular cellulose acetate hydroentangled non-woven fabric by using an extruder, press it tightly, then cover it with a polyester release film, finally cut it into the required shape, package and perform radiation crosslinking to obtain lipid hydrocolloid silver sulfate cellulose acetate dressing.

[0022] Comparative Example 1 The preparation process of the lipid hydrocolloid silver sulfate dressing is exactly the same as that of Example 2, and the only difference compared with Example 2 is that the hollow cellulose acetate hydroentangled non-woven fabric in step S6 is replaced by traditional gauze.

[0023] Test Example The lipid hydrocolloid silver sulfate cellulose acetate dressings prepared in Examples 1-3 and Comparative Example 1 are used as samples, and the samples are subjected to corresponding tests, and the test methods are as shown below, and the specific test results are shown in Table 1: (1) Compression strength test: under room temperature conditions, prepare a cylindrical gel with a diameter of 20 mm and a height of 5 mm by using a twelve-hole plate, perform compression test on the sample by using a texture analyzer until it is crushed, set the compression rate to 0.5 mm / s, and repeat the compression test for each group of samples five times; (2) Tensile strength and elongation at break test: cut the sample into dumbbell shape with a cutter, the total length of the sample is 75 cm, the length of the test part is 40 mm, and the width is 4 mm, clamp the upper and lower ends of the sample to the tensile testing machine, and stretch at a tensile speed of 100 mm / min, measure the tensile strength and elongation at break when the sample is broken, and test three times for each sample to take the average value; (3) Antibacterial performance test: 0.1 g of the sample was taken and mixed with 10 mL of 1x10 7 CFU / mL of E. coli and S. aureus bacterial solution into a test tube, and placed on a constant temperature incubation shaker at 37°C and 120 r / min for 4 h, then incubated in a shaking incubator under indoor natural light conditions for 24 h, and the inhibition rate was calculated by plate colony counting method, wherein the calculation method of the inhibition rate is as follows: inhibition rate = (M1-M2) / M1x100%, wherein M1 and M2 are the initial number of colonies and the number of colonies after culture, respectively.

[0024] Table 1 Performance test results of the lipid hydrocolloid silver sulfate acetate fiber dressings prepared in Examples 1-3 and Comparative Example 1 of the present application As can be seen from the data in Table 1, the compression strength, tensile strength, elongation at break and antibacterial rate of the lipid hydrocolloid silver sulfate acetate fiber dressings prepared in Examples 1-3 of the present application are all better than those of Comparative Example 1, which shows that the hollow reticular acetate fiber non-woven fabric is used as the surface layer of the dressing, and the hollow acetate fiber has better mechanical strength and elasticity than the traditional gauze, thereby improving the mechanical strength and elasticity of the dressing, ensuring that the dressing is particularly soft and easy to deform, has good compliance for wounds that are difficult to fix, and further improves the antibacterial performance of the dressing.

[0025] The lipid hydrocolloid silver sulfate acetate fiber dressings prepared in Examples 1-3 are subjected to drug release under infrared irradiation. Before infrared irradiation, the dressing presents a multilayer structure, and with the photothermal effect under infrared irradiation, the outer layer material in the multilayer structure gradually decomposes, and the transforming growth factor in it is released to the outside, until the outer layer material is completely decomposed after a period of infrared light irradiation, and the drug is completely released, only the dressing particles at the core can be seen, which shows that the lipid hydrocolloid silver sulfate acetate fiber dressing prepared in the present application can continuously deliver transforming growth factor under infrared light irradiation.

[0026] Finally, it should be noted that although embodiments of the present application have been shown and described, those of ordinary skill in the art can understand that various changes, modifications, replacements and variations can be made to these embodiments without departing from the principles and spirits of the present application, and any equivalent changes and improvements made within the scope of the present application should still fall within the scope of the present application.

Claims

1. A process for the preparation of a lipid hydrocolloid silver sulphadiazine acetate gauze dressing, characterized by, It comprises the following steps: Step S1, thermoplastic rubber, liquid paraffin, tackifying resin, antioxidant and plasticizer are added into a kneader in turn, and stirred to mix them uniformly under heating to obtain a mixture 1; Step S2, sodium carboxymethyl cellulose and silver sulfate are added into the mixture 1 obtained in step S1, and stirred to mix them uniformly under heating; Step S3, medical Vaseline is heated to 60°C for standby; Step S4, dimethyl silicone oil, liquid paraffin and citric acid are mixed according to a certain weight ratio to obtain a mixture 3; Step S5, the medical Vaseline heated to 60°C in step S3 is mixed with the mixture 3 obtained in step S4, and cooled to room temperature to obtain a mixture 4, which is added into the mixture 2 obtained in step S2, and stirred to mix them uniformly to obtain a hydrocolloid cream; Step S6, the hydrocolloid cream obtained in step S5 is uniformly coated on a hollow reticular cellulose acetate hydroentangled non-woven fabric by using an extruder, and then compressed, covered with a polyester release film, and finally cut into a desired shape, packaged and subjected to radiation crosslinking to obtain a lipid hydrocolloid silver sulfate cellulose acetate dressing. The thermoplastic rubber in step S1 is any one of SBS, SEBS, TPU and ethylene-propylene rubber; the tackifying resin is any one of petroleum resin, glycerol ester of rosin and gum rosin; the antioxidant is any one of 2, 6-di-tert-butyl phenol, 2, 5-di-tert-butyl quinoline and 2, 6-di-tert-butyl-4-methyl phenol; and the plasticizer is any one of dioctyl adipate, dioctyl phthalate and dibutyl phthalate.

2. A process for the preparation of a lipid hydrocolloid silver sulphadiazine acetate gauze dressing as claimed in claim 1, wherein, The weight ratio of the thermoplastic rubber, liquid paraffin, tackifying resin, antioxidant and plasticizer in step S1 is 40:25:5:5:

1.

3. A process for the preparation of a lipid hydrocolloid silver sulphadiazine acetate gauze dressing as claimed in claim 1, wherein, The heating temperature in step S1 is 70-120°C, the stirring speed is 40-60 r / min, and the stirring time is 2.5-4 h.

4. A process for the preparation of a lipid hydrocolloid silver sulphadiazine acetate gauze dressing as claimed in claim 1, wherein, The weight ratio of the mixture 1, sodium carboxymethyl cellulose and silver sulfate in step S2 is 35:10:

3.

5. A process for the preparation of a lipid hydrocolloid silver sulphadiazine acetate gauze dressing as claimed in claim 1, wherein, The heating temperature in step S2 is 70-120°C, the stirring speed is 50-80 r / min, and the stirring time is 3-6 h.

6. A process for the preparation of a lipid hydrocolloid silver sulphadiazine acetate gauze dressing as claimed in claim 1, wherein, The weight ratio of the dimethyl silicone oil, liquid paraffin and citric acid in step S4 is 12.5:10:

1.

7. A process for the preparation of a lipid hydrocolloid silver sulphadiazine acetate gauze dressing as claimed in claim 1, wherein, The weight ratio of the medical Vaseline to the mixture 3 in step S5 is 1:1, and the weight ratio of the mixture 4 to the mixture 2 in step S5 is 8:

1.

8. A process for the preparation of a lipid hydrocolloid silver sulphadiazine acetate gauze dressing as claimed in claim 1, wherein, It is prepared by using the preparation process of the lipid hydrocolloid silver sulfate cellulose acetate dressing according to any one of claims 1-8.

9. A lipid hydrogel silver sulphadiazine acetate fibrous dressing, characterized in that, 10. The lipid hydrocolloid silver sulfate cellulose acetate dressing according to claim 9 for use in delivering a medicament. ​

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