External traditional Chinese medicine composition for treating swallowing dysfunction after cerebral apoplexy and application of external traditional Chinese medicine composition

Abstract

The invention relates to an external traditional Chinese medicine composition for treating swallowing dysfunction after cerebral apoplexy. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 7-11 parts of fructus chebulae, 7-11 parts of mint, 4-8 parts of rhodiola rosea, 4-8 parts of safflower, 16-20 parts of pinellia ternate, 10-14 parts of pericarpium citri reticulatae and 4-8 parts of bamboo shavings. The invention further provides application of the traditional Chinese medicine composition. The whole formula is balanced in cold and heat, dynamic and static are combined, and a compatibility system of reducing phlegm and calming adverse-rising energy to dredge channels, tonifying qi and activating blood to strengthen power and inducing astringency and relieving sore-throat to protect local parts is formed aiming at four core pathogenesis of phlegm, qi, deficiency and blood stasis of swallowing dysfunction. All the medicines are combined to achieve the effects of astringing throat, relieving stagnation, reducing phlegm, regulating qi and considering qi and blood. The traditional Chinese medicine composition disclosed by the invention has the advantages of direct action, safe medication, simplicity and easiness in operation, wide material sources, low price, simple medicine, definite curative effect, noninvasive and painless effects and the like when being used for atomization treatment.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of traditional Chinese medicine, in particular to a kind of external use traditional Chinese medicine composition for treating dysphagia after stroke and application thereof. BACKGROUND

[0002] Dysphagia after stroke refers to the influence of cerebrovascular disease on swallowing center and motor sensory pathway, which is manifested as choking when drinking water, swallowing sticky feeling, difficulty swallowing, swallowing fatigue, and a large amount of foam sputum in the oral cavity.

[0003] The treatment methods of dysphagia after stroke include food-related precautions, screening of dysphagia, assessment of dysphagia, treatment after stroke, diet and nutrition of dysphagia patients, and guidelines for stroke dysphagia.

[0004] Chinese patent document CN103768539A discloses a traditional Chinese medicine opening and relieving throat stick for treating dysphagia after stroke, which can effectively solve the medication problem of dysphagia after stroke. The technical solution solved by the present application is that the traditional Chinese medicine opening and relieving throat stick comprises a stick body and a traditional Chinese medicine liquid. The stick body is composed of a stick body and a sterilized cotton layer wound on the stick body. The sterilized cotton layer has traditional Chinese medicine liquid adsorbed thereon. The traditional Chinese medicine liquid is prepared from the following raw materials by weight: musk 8-12g, borneol 8-12g, styrax 8-12g, camphor 8-12g, acorus 8-10g, dendrobium 8-10g, dried tangerine or orange peel 5-7g, platycodon 5-7g, curcuma 8-10g, and licorice 2-4g. The present application has the advantages of rich materials, simple prescription, low price, easy production, convenient use, good effect, safe medication, and the functions of aromatic opening, dredging collaterals and relieving throat.

[0005] Such traditional Chinese medicine compositions for treating dysphagia after stroke have the following disadvantages: too many flavors, difficult to obtain materials, expensive, no obvious effect, and poor treatment effect. Therefore, there is an urgent need for a traditional Chinese medicine composition for treating dysphagia after stroke, which has obvious effect, fewer flavors, practicality, high compliance, safety and effectiveness. SUMMARY

[0006] The present application aims to overcome the shortcomings of the prior art and provide a kind of external use traditional Chinese medicine composition for treating dysphagia after stroke and application thereof.

[0007] In the first aspect, the present application provides an external use traditional Chinese medicine composition for treating dysphagia after stroke, which is prepared from the following raw materials by weight: Terminalia chebula 7-11 parts, Mentha haplocalyx 7-11 parts, Rhodiola rosea 4-8 parts, Carthamus tinctorius 4-8 parts, Pinellia ternata 16-20 parts, dried tangerine or orange peel 10-14 parts, and bamboo charcoal 4-8 parts.

[0008] As a preferred example, the traditional Chinese medicine composition is made from the following raw materials in parts by weight: 8-10 parts of Terminalia chebula, 8-10 parts of Mentha haplocalyx, 5-7 parts of Rhodiola rosea, 5-7 parts of Carthamus tinctorius, 17-19 parts of Pinellia ternata, 11-13 parts of Citrus reticulata peel, and 5-7 parts of Bambusa textilis.

[0009] As a preferred example, the traditional Chinese medicine composition is made from the following raw materials in parts by weight: 9 parts Terminalia chebula, 9 parts Mentha haplocalyx, 6 parts Rhodiola rosea, 6 parts Carthamus tinctorius, 18 parts Pinellia ternata, 12 parts Citrus reticulata peel, and 6 parts Bambusa textilis.

[0010] As a preferred example, the traditional Chinese medicine composition is an atomized dosage form.

[0011] Secondly, the present invention provides the application of a traditional Chinese medicine composition in the preparation of a drug for treating dysphagia after stroke.

[0012] The advantages of this invention are:

[0013] This invention relates to a traditional Chinese medicine composition created under the guidance of traditional Chinese medicine theory and clinical experience. Traditional Chinese medicine believes that dysphagia is often related to obstructed qi flow in the throat, phlegm stagnation, and local malnutrition (such as phlegm sticking to the throat, abnormal qi flow, and weak throat mucosa contraction). Terminalia chebula (He Zi) is sour and astringent in taste, neutral in nature, and enters the lung, large intestine, and stomach meridians. Its core functions are to astringe the lungs and benefit the throat, and to astringe the intestines and stop diarrhea. Its "sour and astringent nature" can astringe the throat mucosa, improving dysphagia caused by throat relaxation or mucosal malnutrition; its "benefiting the throat" effect directly acts on the local throat, relieving the obstruction caused by phlegm adhesion, making it the core drug for the main symptom of "dysphagia." The key to dysphagia is "weak throat qi contraction + phlegm obstruction of the passage." Terminalia chebula, by "astringing the throat," solves the "weak contraction," laying the foundation for the entire formula to "unblock stagnation without harming the throat," and is the principal drug. Peppermint (Bo He) is pungent and cool, enters the lung and liver meridians, and disperses wind-heat, clears the head and eyes, and benefits the throat. For some patients with swallowing difficulties, symptoms such as dryness, itching, burning, and a foreign body sensation in the throat are noticeable. Peppermint can clear away wind-heat in the throat, relieving local heat and itching. Its pungent and dispersing properties can also open up throat obstruction and promote the flow of qi in the throat, reducing local resistance to the downward movement of food; therefore, it is an assistant herb. Pinellia and tangerine peel work by "resolving phlegm and regulating qi," clearing the obstruction for Terminalia chebula's "astringent and unblocking" effects. Pinellia is pungent and warm in nature, entering the spleen, stomach, and lung meridians, and its functions include drying dampness, resolving phlegm, and relieving nausea and vomiting. Traditional Chinese medicine believes that "the spleen is the source of phlegm, and the lungs are the receptacle of phlegm." Difficulty swallowing is often accompanied by "phlegm sticking to the throat" (such as a sticky throat and difficulty expectorating phlegm). Pinellia can dry dampness and eliminate "damp phlegm" generated by the spleen and stomach, while also relieving nausea and vomiting (preventing stomach qi from rising and worsening swallowing difficulties), thus resolving the obstruction from the "source of phlegm generation." Tangerine peel is pungent and bitter, warm in nature, entering the spleen and lung meridians, and its functions include regulating qi, strengthening the spleen, drying dampness, and resolving phlegm. "When Qi flows smoothly, phlegm dissipates." Its "qi-regulating" function promotes the flow of Qi in the spleen and stomach, assisting Pinellia in resolving phlegm. Its "spleen-strengthening" effect enhances the spleen's digestive capacity, reducing the regeneration of phlegm. Together with Pinellia, it forms a synergistic effect of "resolving phlegm, regulating Qi, and strengthening the spleen," clearing existing phlegm and preventing it from obstructing the throat again. Bamboo shavings are sweet and slightly cold in nature, entering the lung, stomach, heart, and gallbladder meridians. Their functions include clearing heat, resolving phlegm, relieving irritability, and stopping vomiting. The "slightly cold" nature of bamboo shavings counteracts the warming and drying properties of Pinellia and tangerine peel, preventing "warmth and dryness from damaging body fluids" and worsening throat discomfort. Bamboo shavings can clear "heat phlegm," enhancing the overall phlegm-resolving power of the formula for swallowing difficulties caused by "phlegm-heat accumulation." The combination of peppermint and bamboo shavings, with the cooling properties of peppermint, further enhances the heat-clearing power of bamboo shavings, strengthening the throat-soothing effect for throat discomfort caused by phlegm-heat or wind-heat. If dysphagia has a long course (such as chronic illness affecting the collaterals), it is easy to develop "poor blood and qi circulation and local blood stasis" (such as stagnation of the pharyngeal mucosa and a fixed feeling of obstruction when swallowing). Safflower has a strong blood-activating effect and can improve the insufficient local blood and qi nourishment caused by blood stasis, relieve slowed esophageal peristalsis and sluggish swallowing reflex. When combined with Rhodiola rosea, it can both "tonify qi and activate blood" and "effectively disperse blood stasis", synergistically improving the pathological basis of qi deficiency and blood stasis. "Phlegm and blood stasis share the same origin". Phlegm turbidity easily leads to blood stasis. Safflower's blood-activating effect can help dissipate phlegm turbidity. Together with Pinellia ternata and Citrus reticulata, it forms a "phlegm-resolving + blood-activating" synergy, solving the complex pathogenesis of "phlegm and blood stasis intertwined".Rhodiola rosea is used as the guiding herb. It is sweet and bitter in taste, slightly warm in nature, and enters the lung and heart meridians. Its functions include invigorating qi and blood circulation, clearing the meridians, and relieving asthma. In this formula, bamboo shavings are slightly cold, while pinellia and tangerine peel are pungent and warm. Rhodiola rosea, being "slightly warm and mild," balances the overall cold and heat properties of the formula, preventing either excessive coldness from damaging yang or excessive warmth from promoting heat. Difficulty swallowing is related to "spleen and stomach qi deficiency and weak digestion." Rhodiola rosea's "qi-tonifying" function enhances the spleen's digestive capacity, assists pinellia and tangerine peel in resolving phlegm, and provides "vital energy support" for chebula's "soothing the throat" effect. Rhodiola rosea also guides the medicine directly to the affected area; its "blood-activating and meridian-clearing" power directs the other herbs (such as chebula and safflower) through qi and blood circulation to the throat, enhancing local efficacy. The combined effects of these herbs achieve "soothing the throat, clearing stagnation, resolving phlegm, regulating qi, and simultaneously addressing qi and blood stagnation." Detailed Implementation

[0014] The present invention will be further described below with reference to specific embodiments. It should be understood that these embodiments are for illustrative purposes only and are not intended to limit the scope of the invention. Furthermore, it should be understood that after reading the description of this invention, those skilled in the art can make various alterations or modifications to the invention, and these equivalent forms also fall within the scope defined by the appended claims.

[0015] Example 1: External Traditional Chinese Medicine Composition for Treating Swallowing Dysfunction After Stroke (Part 1)

[0016] 9 parts Terminalia chebula, 9 parts Mentha haplocalyx, 6 parts Rhodiola rosea, 6 parts Carthamus tinctorius, 18 parts Pinellia ternata, 12 parts Citrus reticulata peel, and 6 parts Bambusa textilis.

[0017] Example 2: External Traditional Chinese Medicine Composition for Treating Swallowing Dysfunction After Stroke (II)

[0018] 9 parts Terminalia chebula, 8 parts Mentha haplocalyx, 7 parts Rhodiola rosea, 4 parts Carthamus tinctorius, 20 parts Pinellia ternata, 12 parts Citrus reticulata peel, and 5 parts Bambusa textilis.

[0019] Example 3: External Traditional Chinese Medicine Composition for Treating Swallowing Dysfunction After Stroke (Part Three)

[0020] 8 parts Terminalia chebula, 10 parts Mentha haplocalyx, 4 parts Rhodiola rosea, 8 parts Carthamus tinctorius, 18 parts Pinellia ternata, 11 parts Citrus reticulata peel, and 7 parts Bambusa textilis.

[0021] Example 4: External Traditional Chinese Medicine Composition for Treating Swallowing Dysfunction After Stroke (IV)

[0022] 10 parts Terminalia chebula, 7 parts Mentha haplocalyx, 8 parts Rhodiola rosea, 6 parts Carthamus tinctorius, 17 parts Pinellia ternata, 13 parts Citrus reticulata peel, and 4 parts Bambusa textilis.

[0023] Example 5: External Traditional Chinese Medicine Composition for Treating Swallowing Dysfunction After Stroke (V)

[0024] 7 parts Terminalia chebula, 11 parts Mentha haplocalyx, 6 parts Rhodiola rosea, 5 parts Carthamus tinctorius, 19 parts Pinellia ternata, 10 parts Citrus reticulata peel, and 8 parts Bambusa textilis.

[0025] Example 6: External Traditional Chinese Medicine Composition for Treating Swallowing Dysfunction After Stroke (VI)

[0026] 11 parts Terminalia chebula, 9 parts Mentha haplocalyx, 5 parts Rhodiola rosea, 7 parts Carthamus tinctorius, 16 parts Pinellia ternata, 14 parts Citrus reticulata peel, and 6 parts Bambusa textilis.

[0027] Example 7: External Traditional Chinese Medicine Composition for Treating Swallowing Dysfunction After Stroke (VII)

[0028] 8 parts Terminalia chebula, 10 parts Mentha haplocalyx, 4 parts Rhodiola rosea, 8 parts Carthamus tinctorius, 18 parts Pinellia ternata, 11 parts Citrus reticulata peel, and 7 parts Bambusa textilis.

[0029] Example 8: External Traditional Chinese Medicine Composition for Treating Swallowing Dysfunction After Stroke (VIII)

[0030] 10 parts Terminalia chebula, 7 parts Mentha haplocalyx, 8 parts Rhodiola rosea, 6 parts Carthamus tinctorius, 17 parts Pinellia ternata, 13 parts Citrus reticulata peel, and 4 parts Bambusa textilis.

[0031] Example 9: External Traditional Chinese Medicine Composition for Treating Post-Stroke Swallowing Dysfunction (IX)

[0032] 7 parts Terminalia chebula, 11 parts Mentha haplocalyx, 6 parts Rhodiola rosea, 5 parts Carthamus tinctorius, 19 parts Pinellia ternata, 10 parts Citrus reticulata peel, and 8 parts Bambusa textilis.

[0033] Example 10: External Traditional Chinese Medicine Composition for Treating Post-Stroke Swallowing Dysfunction (X)

[0034] 11 parts Terminalia chebula, 9 parts Mentha haplocalyx, 5 parts Rhodiola rosea, 7 parts Carthamus tinctorius, 16 parts Pinellia ternata, 14 parts Citrus reticulata peel, and 6 parts Bambusa textilis.

[0035] Example 11: External Traditional Chinese Medicine Composition for Treating Post-Stroke Swallowing Dysfunction (XI)

[0036] 9 parts Terminalia chebula, 8 parts Mentha haplocalyx, 7 parts Rhodiola rosea, 4 parts Carthamus tinctorius, 20 parts Pinellia ternata, 12 parts Citrus reticulata peel, and 5 parts Bambusa textilis.

[0037] Example 12 Clinical Efficacy Trial

[0038] 1.1 General Information A total of 40 patients were enrolled, all from our ward, and all had a history of dysphagia following stroke. They were randomly divided into an observation group (n=20) and a control group (n=20). The observation group consisted of 12 males and 8 females, aged 58 years. ～ The patient was 82 years old, with a mean age of (69.65 ± 11.58) years; the duration of dysphagia was 70 years. ～ The duration of the illness was 122 days, with an average of (94.62 ± 25.13) days. The control group consisted of 11 males and 9 females, with an age range of 59 years. ～ The average age of the patients was 80 years, with a mean age of (68.42 ± 10.42) years; the duration of dysphagia was 69 years. ～The duration was 118 days, with an average of (93.35±23.56) days. There were no statistically significant differences in general characteristics between the two groups (P>0.05), indicating they were comparable.

[0039] 1.2 Diagnostic criteria in Traditional Chinese Medicine and Western Medicine:

[0040] The diagnostic criteria for ischemic stroke are based on the "Chinese Guidelines for the Diagnosis and Treatment of Acute Ischemic Stroke 2023". [1] The patient presented with focal neurological deficits and signs, confirmed by imaging examinations. The diagnostic criteria for post-stroke dysphagia are based on the "Guidelines for the Rehabilitation Management of Dysphagia in China (2023 Edition)". [2] A diagnosis can be made when food or liquid cannot be safely and effectively delivered to the stomach during oral feeding, and aspiration is observed on pharyngography or endoscopy, or when clinical signs of aspiration are present, or when a nasogastric tube is required for nutritional support.

[0041] 1.3 Inclusion criteria:

[0042] ① Those who meet the above diagnostic criteria; ② Those who are ≥18 years old; ③ Those who are aware of the content and purpose of the experiment and voluntarily sign the informed consent form.

[0043] 1.4 Exclusion Criteria:

[0044] Other causes of dysphagia; coexisting malignant tumors or damage to vital organ function; mental illness or cognitive impairment; intolerance to the treatment methods used in this study (previous adverse reactions to traditional Chinese medicine treatment or allergy to drug components).

[0045] 1.5 Shedding Criteria:

[0046] ① Those who withdraw from the study midway due to any subjective or objective factors; ② Those who fail to follow medical advice, resulting in the inability to judge the efficacy or incomplete data.

[0047] 1.6 Clinical Research Methods:

[0048] This study used a concentrated decoction of traditional Chinese medicine for nebulized inhalation as an intervention, with both groups receiving the intervention for 4 weeks. Clinical efficacy, swallowing and feeding function, nutritional status, and quality of life were compared between the two groups to provide a comprehensive analysis of the clinical efficacy of this therapy.

[0049] 1.7 Clinical efficacy evaluation methods:

[0050] (1) Clinical efficacy. Marked effect: Symptoms related to dysphagia disappeared, and the Kubota water swallowing test was grade I. Effective: Symptoms of dysphagia were alleviated, and the Kubota water swallowing test decreased to grade II. Ineffective: Symptoms of dysphagia remained unchanged, and the Kubota water swallowing test was ≥ grade III. The total effective rate of treatment = (marked effect + effective) / total number of cases × 100%. (2) Swallowing and feeding function: Before and after the intervention, the swallowing function of both groups was evaluated by the Swallowing Function Assessment Scale (SSA), with a score of 18.～ A score of 46 indicates that a lower score indicates better swallowing function; the Functional Oral Intake Scale (FOIS) was used to evaluate feeding function. ～ 7 points, the higher the score, the better the patient’s eating function. (3) Nutritional status: Before and after the intervention, blood samples were collected from both groups to measure albumin (ALB) and total protein (TP) levels.

[0051] 2 Treatment methods

[0052] 2.1 The observation group received traditional Chinese medicine nebulization therapy in addition to the treatment given to the control group.

[0053] 2.1.1 Composition of the prescription

[0054] Terminalia chebula 9g, Mentha haplocalyx 9g, Rhodiola rosea 6g, Carthamus tinctorius 6g, Pinellia ternata 18g, Citrus reticulata peel 12g, Bambusa textilis 6g.

[0055] 2.1.2 Methods

[0056] The control group received oral function training intervention. (1) Lip closure exercise: Instruct the patient to sit facing a mirror and keep their lips closed. ～ Rest for 5 minutes and repeat the exercise twice a day. (2) Jaw exercises: Instruct the patient to open their mouth first, relax their jaw, and then perform jaw movements. ～ Rest for 5 minutes and repeat the exercise twice a day. (3) Empty swallowing exercise: Instruct the patient to close their lips, with the tongue pressed firmly against the hard palate, simulating the action of swallowing water, 5 minutes later. ～ 10 reps / set, 3 sets / day. (4) Tongue muscle training: With mouth open or closed, move the tongue up, down, left, and right to exercise 1. ～ Rest for 5 minutes and repeat the exercise twice a day.

[0057] The observation group received additional intervention using the concentrated decoction of traditional Chinese medicine from this invention via nebulization. 9g of Terminalia chebula, 9g of Mentha haplocalyx, 6g of Rhodiola rosea, 6g of Carthamus tinctorius, 18g of Pinellia ternata, 12g of Citrus reticulata peel, and 6g of Bambusa textilis shavings (dried medicinal slices) were decocted in water, yielding 200mL of liquid. This liquid was refrigerated and stored. 10mL of the liquid was inhaled for 15 minutes each time, twice daily. Oral function training was conducted after each nebulization session. Both groups received the intervention for 4 weeks.

[0058] 3. Adverse reaction evaluation:

[0059] This study will record and analyze adverse reactions in subjects who experience adverse reactions or discontinue the study, and will conduct a one-week follow-up survey to assess the adverse reactions of this treatment.

[0060] 4. Treatment Results

[0061] 4.1 Comparison of clinical efficacy between the two groups:

[0062] The total effective rate of treatment in the observation group was higher than that in the control group, and the difference was statistically significant (P<0.05).

[0063] Table 1. Comparison of clinical efficacy between two groups of stroke patients with dysphagia (n%)

[0064]

[0065] Note: For intergroup comparisons, *P<0.05;

[0066] 4.2 Rating Criteria for the Scale

[0067] 4.2.1 Comparison of swallowing and feeding functions between the two groups

[0068] Before the intervention, there were no statistically significant differences in SSA and FOIS scores between the two groups (P > 0.05). After the intervention, the SSA score in the observation group was lower than that in the control group, while the FOIS score was higher, and the differences between the groups were statistically significant (P < 0.05). See Table 2.

[0069] Table 2 Comparison of swallowing and feeding functions between two groups of stroke patients with dysphagia ( point)

[0070]

[0071] Note: Within-group comparisons, *P<0.01, **P<0.05; Compared with the control group at the same time point, #P<0.05

[0072] 4.2.2 Comparison of nutritional status between the two groups

[0073] Before the intervention, there was no statistically significant difference in ALB and TP levels between the two groups (P > 0.05). After the intervention, the ALB and TP levels in the observation group were higher than those in the control group, and the difference between the groups was statistically significant (P < 0.05). See Table 3.

[0074] Table 3 Comparison of nutritional status between the two groups of stroke patients with dysphagia ( g / L)

[0075]

[0076]

[0077] Note: Within-group comparisons, *P<0.01, **P<0.05; Compared with the control group at the same time point, #P<0.05

[0078] 5. Adverse reaction evaluation:

[0079] No significant adverse reactions occurred in either group during the treatment.

[0080] It should be noted that: Usually, when treating patients with traditional Chinese medicine or Western medicine atomization, there are generally side effects such as dry mouth, dry throat, cough, and local irritation. However, in the present invention: When using the present invention (Terminalia chebula 9g, Mentha haplocalyx 9g, Rhodiola rosea 6g, Carthamus tinctorius 6g, Pinellia ternata 18g, Citrus reticulata 12g, Bambusa ventricosa 6g) for atomizing patients with dysphagia after stroke, no side effects such as dry mouth, dry throat, cough, and local irritation were found.

[0081] 6. Discussion:

[0082] Traditional Chinese medicine believes that the pathogenesis of dysphagia after stroke in traditional Chinese medicine is: blood stasis and mutual binding, disturbing the marrow sea upwards, resulting in speech obstruction and swallowing disorder. Therefore, the treatment of this disease should be mainly based on "astringing the throat and dredging stagnation, resolving phlegm and regulating qi, and taking into account qi and blood". In the traditional Chinese medicine compound atomizing agent used in this study, Pinellia ternata dries dampness and resolves phlegm, descends adverse qi and harmonizes the stomach, and is the core for resolving phlegm and dredging the esophagus, relieving the obstruction of phlegm turbidity congesting the throat; Citrus reticulata regulates qi and strengthens the spleen, assisting Pinellia ternata in promoting phlegm movement, and preventing the regeneration of phlegm turbidity; Bambusa ventricosa clears heat and resolves phlegm, balancing the warm and dry properties of Pinellia ternata and Citrus reticulata, and is suitable for treating sticky phlegm and choking cough caused by phlegm heat. Rhodiola rosea supplements qi and promotes blood circulation, tonifying the qi of the lung and spleen to strengthen the swallowing power, and simultaneously dredging the collaterals; Carthamus tinctorius has a strong effect of promoting blood circulation and dredging collaterals, dispersing blood stasis in the throat and esophagus, and improving local nourishment. Mentha haplocalyx is pungent and cool, relieving sore throat, clearing heat disturbance in the throat, Terminalia chebula relieves sore throat and astringes, protecting the body fluid of the throat, relieving the foreign body sensation in the dry throat, and taking into account the dispersing properties of the drugs in the formula. The whole formula has a balance between cold and heat, combines movement and stillness, and forms a compatibility system of "resolving phlegm and descending adverse qi to dredge the passage, supplementing qi and promoting blood circulation to strengthen the power, and astringing and relieving sore throat to protect the local area" for the four core pathogenesis of "phlegm, qi, deficiency, and blood stasis" of swallowing dysfunction, and this group of drugs is the core for resolving phlegm and descending adverse qi and dredging the esophagus.

[0083] Considering that most of the traditional Chinese medicines currently used clinically are mainly decoctions and pills, it may be difficult for patients to swallow them, and the cough and choking symptoms will be aggravated during the treatment. Therefore, this study mainly uses a traditional Chinese medicine compound atomizing agent for atomizing inhalation treatment. The drug can directly reach the patient's throat, with accurate dosage, safe and controllable. Using the traditional Chinese medicine composition of the present invention for atomizing treatment has the advantages of direct action, safe medication, simple and easy to operate, wide range of materials, low cost, definite curative effect, non-invasive and painless, etc.

[0084] References:

[0085] [1] Chinese Medical Association Neurology Branch, Cerebrovascular Diseases Group of Chinese Medical Association Neurology Branch. Guidelines for the Diagnosis and Treatment of Acute Ischemic Stroke in China 2023 [J]. Chinese Journal of Neurology, 2024, 57(6): 523 - 559.

[0086] [2] Chinese Association of Rehabilitation Medicine, Committee on Swallowing Disorders Rehabilitation. Guidelines for the Management of Swallowing Disorders Rehabilitation in China (2023 Edition) [J]. Chinese Journal of Physical Medicine and Rehabilitation, 2023, 45(12): 1057-1072. The above description is only a preferred embodiment of the present invention. It should be noted that for those skilled in the art, several improvements and additions can be made without departing from the method of the present invention, and these improvements and additions should also be considered as the scope of protection of the present invention.

Claims

1. A topical traditional Chinese medicine composition for treating dysphagia after stroke, characterized in that, The traditional Chinese medicine composition is made from the following raw materials in parts by weight: 7-11 parts of Terminalia chebula, 7-11 parts of Mentha haplocalyx, 4-8 parts of Rhodiola rosea, 4-8 parts of Carthamus tinctorius, 16-20 parts of Pinellia ternata, 10-14 parts of Citrus reticulata peel, and 4-8 parts of Bambusa textilis.

2. The traditional Chinese medicine composition according to claim 1, characterized in that, The traditional Chinese medicine composition is made from the following raw materials in parts by weight: 8-10 parts of Terminalia chebula, 8-10 parts of Mentha haplocalyx, 5-7 parts of Rhodiola rosea, 5-7 parts of Carthamus tinctorius, 17-19 parts of Pinellia ternata, 11-13 parts of Citrus reticulata peel, and 5-7 parts of Bambusa textilis.

3. The traditional Chinese medicine composition according to claim 1, characterized in that, The traditional Chinese medicine composition is made from the following raw materials in parts by weight: 9 parts Terminalia chebula, 9 parts Mentha haplocalyx, 6 parts Rhodiola rosea, 6 parts Carthamus tinctorius, 18 parts Pinellia ternata, 12 parts Citrus reticulata peel, and 6 parts Bambusa textilis.

4. The traditional Chinese medicine composition according to any one of claims 1-3, characterized in that, The traditional Chinese medicine composition is an atomized dosage form.

5. The use of the traditional Chinese medicine composition according to any one of claims 1-3 in the preparation of a drug for treating dysphagia after stroke.

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