Transcranial magnetic stimulation nerve regulation and control device and use method thereof

Abstract

The invention relates to a transcranial magnetic stimulation nerve regulation device which comprises a sleep tracker and a time-varying magnetic field generator, the sleep tracker is used for collecting signals of physiological signs when a human body sleeps, and the time-varying magnetic field generator controls output of a time-varying magnetic field according to the signals collected by the sleep tracker. The invention further relates to a using method of the transcranial magnetic stimulation nerve regulation and control device. The using method comprises the steps that sleep state information collected by the sleep tracker is obtained; and according to the obtained sleep state information, enabling the time-varying magnetic field generator to output a time-varying magnetic field with preset parameters when a preset sleep state in a preset time period starts or ends. The transcranial magnetic stimulation nerve regulation and control device controls the time-varying magnetic field generator to output a specific rhythm magnetic field to the brain so as to improve the functional activity of inhibitory interneurons. According to the use method provided by the invention, the function of a certain type of nerve cells is regulated and controlled by outputting an electric field induced by a time-varying magnetic field with a specific rhythm and coupling the electric field with an inherent oscillation rhythm of the specific type of nerve cells.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of transcranial magnetic stimulation nerve regulation, and particularly relates to a transcranial magnetic stimulation nerve regulation device and a use method thereof. BACKGROUND

[0002] Sleep is a brain function state different from the state of wakefulness, and sleep has different stages, including rapid eye movement and non-rapid eye movement, and the non-rapid eye movement is divided into deep sleep and light sleep. How to increase the duration and proportion of deep sleep, and how to change the light sleep state into the deep sleep state have important values for improving brain health and treating brain diseases, and are a long-term research topic in the scientific community, and there is no prior art and method verified to be effective. SUMMARY

[0003] Therefore, the present application aims at the deficiencies of the prior art, and provides a transcranial magnetic stimulation nerve regulation device and a use method thereof, so as to increase the duration and proportion of deep sleep, improve sleep quality, and improve brain function, prevent and treat brain diseases.

[0004] To achieve the above-mentioned purpose, the present application adopts the following technical scheme:

[0005] A transcranial magnetic stimulation nerve regulation device comprises a sleep tracker and a time-varying magnetic field generator, the sleep tracker is used for collecting signals of physiological signs of a human body during sleep, and the time-varying magnetic field generator controls the output of a time-varying magnetic field according to the signals collected by the sleep tracker.

[0006] In order to better realize the present application, the time-varying magnetic field of the time-varying magnetic field generator is further optimized in the above structure, and the strength of the time-varying magnetic field induced electric field is less than 70T / s.

[0007] In order to better realize the present application, the sleep tracker is further optimized in the above structure, and comprises a sign collection module and an algorithm module, the sign collection module is used for collecting signals of physiological signs of a human body during sleep, and the algorithm module analyzes and processes the signals collected by the sign collection module to obtain sleep state information.

[0008] In order to better realize the present application, the sign collection module is further optimized in the above structure, and is a pressure sensor.

[0009] In order to better realize the present application, the sleep state information is further optimized in the above structure, and comprises a wake-up period, a rapid eye movement period, a light sleep period or a deep sleep period of a human body in real time.

[0010] In order to better realize the present application, further optimization is made in the above structure, and a remote server is further included, the remote server is in wireless communication connection with the sleep tracker, and the remote server can control the output of the time-varying magnetic field of the time-varying magnetic field generator according to the signal collected by the sleep tracker.

[0011] A method for using the transcranial magnetic stimulation nerve regulation device, comprising the following steps:

[0012] S1, obtaining the collected sleep state information;

[0013] S2, according to the obtained sleep state information, the time-varying magnetic field generator outputs the time-varying magnetic field with preset parameters at the beginning or end of the preset sleep state in the preset time period, and the preset parameters of the time-varying magnetic field include carrier frequency, single wave pulse width, rhythm formed by string length and empty time length and intermittent output characteristics.

[0014] In order to better realize the present application, further optimization is made in the above structure, the carrier frequency is 1000-20000Hz, the single wave pulse width is 50-400 microseconds, the rhythm is 1-100Hz, and the typical intermittent characteristics are output 2 seconds and stop 8 seconds.

[0015] In order to better realize the present application, further optimization is made in the above structure, the carrier frequency is 2500Hz, and the rhythm is 40Hz.

[0016] In order to better realize the present application, further optimization is made in the above structure, the preset time period is between 0-6 o'clock, the preset sleep state is the beginning of light sleep in the second or third or fourth sleep cycle in this time period, or the beginning of deep sleep in the first or second or third sleep cycle in this time period, or the beginning of rapid eye movement period in the third or fourth or fifth sleep cycle in this time period.

[0017] Compared with the prior art, the present application has the following beneficial effects:

[0018] 1. The transcranial magnetic stimulation nerve regulation device provided by the present application can regulate nerve cells by collecting the physical information of the user in the sleep state and controlling the time-varying magnetic field generator to output a magnetic field to the brain, can improve the functional activity of inhibitory interneurons, and can achieve the purposes of increasing the duration and proportion of deep sleep, or guiding the rapid eye movement period or the light sleep period into deep sleep, and improving brain function, preventing and treating brain diseases.

[0019] 2. The use method of the transcranial magnetic stimulation nerve regulation device provided by the application comprises the following steps: acquiring body sign information of a user in a sleep state, and enabling a time-varying magnetic field generator to output a time-varying magnetic field with preset parameters at the beginning or end of a preset sleep state in a preset time period, so that the electric field induced by the output time-varying magnetic field with a specific rhythm is coupled with the inherent oscillation rhythm of a specific type of nerve cell to realize the regulation of the function of the nerve cell, thereby guiding the user to enter a deep sleep state in a light sleep stage in a certain time period or to induce the user to enter a rapid eye movement sleep stage from a non-rapid eye movement sleep stage, and improving sleep quality. BRIEF DESCRIPTION OF DRAWINGS

[0020] In order to more clearly illustrate the technical solutions in the embodiments of the present application or the prior art, the following will briefly introduce the drawings needed to be used in the embodiments or the prior art description. Obviously, the drawings in the following description are only some embodiments of the present application, and for those skilled in the art, other drawings can also be obtained from these drawings without creative labor.

[0021] Figure 1 is a circuit control diagram of the transcranial magnetic stimulation nerve regulation device of the present application;

[0022] Figure 2 is a fluctuation diagram of a user's whole night sleep state after using the transcranial magnetic stimulation nerve regulation device of the present application.

[0023] In the drawings:

[0024] 1-sleep tracker, 101-body sign acquisition module, 102-algorithm module, 2-time-varying magnetic field generator, 3-remote server. DETAILED DESCRIPTION

[0025] In order to make the purpose, technical solutions and advantages of the present application more clear, the technical solutions of the present application will be described in detail below. Obviously, the described embodiments are only some of the embodiments of the present application, not all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor are within the scope of protection of the present application.

[0026] In the description of the present application, it should be noted that, unless otherwise specified, the meaning of "a plurality of" is two or more; the orientation or positional relationship indicated by the terms "upper", "lower", "left", "right", "inner", "outer", "front end", "rear end", "head", "tail" and the like is based on the orientation or positional relationship shown in the drawings, and is only for the purpose of facilitating the description of the present application and simplifying the description, and does not indicate or imply that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as a limitation on the present application. In addition, the terms "first", "second", "third" and the like are only for the purpose of description and cannot be understood as indicating or implying relative importance.

[0027] In the description of the present application, it should be noted that, unless otherwise specified and limited, the terms "mounting", "connection", "connection" should be understood broadly, for example, it can be fixedly connected, or it can be detachably connected, or integrally connected; it can be mechanically connected, or it can be electrically connected; it can be directly connected, or it can be indirectly connected through an intermediate medium. For those skilled in the art, the specific meaning of the above terms in the present application can be understood according to the specific circumstances.

[0028] Reference Figure 1 The transcranial magnetic stimulation nerve regulation device provided by the present application comprises a sleep tracker 1 and a time-varying magnetic field generator 2. The sleep tracker 1 is used to collect physiological sign signals of a human body in a sleep state, and the time-varying magnetic field generator 2 controls the output regulation of a time-varying magnetic field according to the signals collected by the sleep tracker 1. The time-varying magnetic field generator 2 is used to output a time-varying magnetic field. The electric field induced by the specific rhythm of the time-varying magnetic field output can be coupled with the inherent oscillation rhythm of a specific type of nerve cell to realize the regulation of the function of a certain type of nerve cell. The function activity of inhibitory interneurons can be improved, so as to achieve the purpose of increasing the length and proportion of deep sleep, or inducing into rapid eye movement sleep period in non-rapid eye movement sleep stage, and the like. The brain function is improved, and brain diseases are prevented and treated.

[0029] The strength of the time-varying magnetic field induced electric field of the time-varying magnetic field generator 2 is lower than 70T / s. The time-varying magnetic field generator acts on the whole brain of a human being. The time-varying magnetic field is approximately uniformly distributed or weakly gradient distributed in the whole brain of a human being including deep brain areas.

[0030] The sleep tracker 1 comprises a sign acquisition module 101 and an algorithm module 102, the sign acquisition module 101 is a pressure change or impact force sensitive sensor, which can acquire signals such as heartbeat, breathing and body turning of a person in bed, the algorithm module 102 analyzes and processes analog signals acquired by the sign acquisition module 101 to obtain sleep state information, the sleep state information mainly includes a clear period or a rapid eye movement period or a light sleep period or a deep sleep period of a person in real time, and different time-varying magnetic fields are output at different time points according to the sleep state of the user to improve sleep quality.

[0031] The remote server 3 is further included, the remote server 3 is in wireless communication connection with the sleep tracker 1, the function of the algorithm module 102 can also be realized by the remote server 3, the remote server 3 can control the change of the magnetic field output by the time-varying magnetic field generator 2 according to the signal acquired by the sleep tracker 1, the sleep state of the user can also be monitored in real time through the remote server 3, when it is found that the user cannot normally enter deep sleep, the remote control time-varying magnetic field generator 2 emits a time-varying magnetic field in the REM rapid eye movement period, guiding the user to enter deep sleep and improving sleep quality, compared with relying on the system of the time-varying magnetic field generator 2 to intervene according to the sleep state of the user, the real-time monitoring and control of the remote server 3 is adopted, the guiding process is more accurate, and the output conditions and time-varying magnetic field parameters can also be adjusted in time according to the characteristics of the user.

[0032] In use, the sleep tracker 1 and the time-varying magnetic field generator 2 are placed on the bed or under the pillow, can output a time-varying magnetic field with a weak intensity and a rhythm reaching the deep brain during the sleep of the user, so as to provide an effective intervention means for improving the sleep quality of the user and further improving the brain health.

[0033] A use method of the transcranial magnetic stimulation neural regulation device, comprising the following steps:

[0034] S1, acquiring sleep state information acquired by the sleep tracker 1.

[0035] S2, according to the obtained sleep state information, the time-varying magnetic field generator 2 outputs a time-varying magnetic field with preset parameters at the beginning or end of the preset sleep state in the preset time period, the preset parameters of the time-varying magnetic field include a carrier frequency, a single wave pulse width, a rhythm formed by a string and a blank time length and an intermittent output characteristic. Wherein, the carrier frequency ranges from 1000 to 20000 Hz, preferably 2500 Hz, the single wave pulse width is 100-400 microseconds, the rhythm formed by the string and the blank time length is 1-100 Hz, preferably 40 Hz, and a typical intermittent characteristic is output for 2 seconds and stop for 8 seconds, when the appropriate parameter time-varying magnetic field coupled with the inherent oscillation rhythm of the inhibitory interneuron acts on the brain during sleep, the function activity of the inhibitory interneuron can be better improved.

[0036] The preset time period is between 0-6 o'clock, and the preset sleep state is the start of light sleep in the second, third or fourth sleep cycle in this time period, or the start of deep sleep in the first, second or third sleep cycle in this time period, or the start of the rapid eye movement period in the third, fourth or fifth sleep cycle in this time period.

[0037] The time-varying magnetic field generator 2 outputs a time-varying magnetic field with preset parameters at the start or end of the preset sleep state in the preset time period. For example, the time-varying magnetic field generator starts to work with preset parameters when the user enters the fourth light sleep; or the time-varying magnetic field generator starts to work with preset parameters when the user enters light sleep for the second time, and works with preset parameters each time the user enters light sleep and no more than 5 times a night; or the time-varying magnetic field generator starts to work with preset parameters when the user enters the rapid eye movement sleep period for the fourth time, and different output parameters are set according to the sleep state of the user.

[0038] In the case that the preset parameters do not meet the standards due to poor sleep state and irregular work and rest of the user, the remote server 3 monitors the sleep fluctuations of the user in real time, formulates targeted preset parameters according to different conditions, and improves the applicability of the user, so as to formulate appropriate time-varying magnetic field parameters for the user.

[0039] The rhythmic, deep brain accessible, weak intensity transcranial magnetic stimulation is expected to improve brain health and treat brain diseases by outputting a magnetic field with appropriate parameters to regulate the functional activity of inhibitory interneurons in the whole brain including deep brain regions. Because this kind of magnetic stimulation is realized by coupling the output specific rhythmic time-varying magnetic field induced electric field with the inherent oscillation rhythm of specific types of nerve cells to regulate the function of certain types of nerve cells, therefore, what parameters of magnetic field to output, where to output (such as whether it can act on deep brain regions), and when to output are very important. The preset parameters of the time-varying magnetic field include carrier frequency, strength of the magnetic induced pulse electric field, single wave pulse width, rhythm formed by string length and empty time length, and intermittent output characteristics.

[0040] Reference Figure 2 The test user is set to work the time-varying magnetic field generator at the fourth light sleep stage after 0 o'clock, and output a 30-minute gamma rhythm magnetic field. The result is that the user immediately enters a deep sleep state after the time-varying magnetic field generator 2 works, and then automatically enters a deep sleep state multiple times (without magnetic stimulation), and the total duration of deep sleep at night is 50% longer than the usual 1 hour, reaching 1.5 hours. The arrow in the figure points to the time when the time-varying magnetic field generator 2 starts to output the magnetic field, and the three consecutive deep sleep stages that appear thereafter are enclosed in an oval.

[0041] The above merely illustrates the specific embodiments of the present application, but the protection scope of the present application is not limited thereto, any person skilled in the art can easily think of the changes or replacements within the technical range disclosed by the present application, which should be covered in the protection scope of the present application. Therefore, the protection scope of the present application should be subject to the protection scope of the claims.

Claims

1. A transcranial magnetic stimulation neuromodulation device, characterized by: The sleep tracker (1) is used for collecting signals of physiological signs of human body during sleep, and the time-varying magnetic field generator (2) controls the output of the time-varying magnetic field according to the signals collected by the sleep tracker (1).

2. The transcranial magnetic stimulation neuromodulation device of claim 1, wherein: The strength of the time-varying magnetic field induced electric field of the time-varying magnetic field generator (2) is less than 70T / s.

3. The transcranial magnetic stimulation neuromodulation device of claim 1, wherein: The sleep tracker (1) comprises a sign collection module (101) and an algorithm module (102), the sign collection module (101) is used for collecting signals of physiological signs of human body during sleep, and the algorithm module (102) analyzes and processes the signals collected by the sign collection module (101) to obtain sleep state information.

4. The transcranial magnetic stimulation neuromodulation device of claim 3, wherein: The sign collection module (101) is a pressure sensor.

5. The transcranial magnetic stimulation neuromodulation device of claim 3, wherein: The sleep state information includes the real-time wake period, rapid eye movement period, light sleep period or deep sleep period of the human body.

6. The transcranial magnetic stimulation neuromodulation device of claim 1, wherein: A remote server (3) is further included, which is wirelessly connected with the sleep tracker (1), and can control the output of the time-varying magnetic field of the time-varying magnetic field generator (2) according to the signals collected by the sleep tracker (1).

7. A method of using a transcranial magnetic neuromodulation device as claimed in any one of claims 3-5, characterized in that: The method comprises the following steps: S1, obtaining the collected sleep state information; S2, according to the obtained sleep state information, the time-varying magnetic field generator (2) outputs a time-varying magnetic field with preset parameters at the beginning or end of the preset sleep state in the preset time period, the preset parameters of the time-varying magnetic field include carrier frequency, single wave pulse width, rhythm formed by string length and idle time, and intermittent output characteristics.

8. The method of use of claim 7, wherein: The carrier frequency is 1000-20000Hz, the single wave pulse width is 50-400 microseconds, the rhythm is 1-100Hz, and the typical intermittent characteristics are output for 2 seconds and stop for 8 seconds.

9. The method of use of claim 8, wherein: The carrier frequency is 2500Hz, and the rhythm is 40Hz.

10. The method of use of claim 7, wherein: The preset time period is between 0 and 6 o'clock, the preset sleep state is the beginning of light sleep in the second or third or fourth sleep cycle in this time period, or the beginning of deep sleep in the first or second or third sleep cycle in this time period, or the beginning of rapid eye movement period in the third or fourth or fifth sleep cycle in this time period.

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