Transcranial magnetic stimulation-based neuromodulation apparatus, and method for using same

Abstract

The present invention relates to a transcranial magnetic stimulation-based neuromodulation apparatus, comprising a sleep tracker and a time-varying magnetic field generator. The sleep tracker is used for acquiring signals of physiological signs during human sleep, and the time-varying magnetic field generator controls output of a time-varying magnetic field on the basis of the signals acquired by the sleep tracker. The sleep tracker comprises a sign acquisition module and an algorithm module; and the algorithm module analyzes and processes the acquired signals to obtain sleep state information, wherein the sleep state information comprises a real-time awake phase or rapid eye movement phase or light sleep phase or deep sleep phase of a human. The present invention further relates to a method for using the transcranial magnetic stimulation-based neuromodulation apparatus. The transcranial magnetic stimulation-based neuromodulation apparatus provided by the present invention controls the time-varying magnetic field generator to output a magnetic field having a specific rhythm to the brain to improve the functional activity of inhibitory interneurons, and achieves modulation of the functions of certain types of nerve cells by coupling an electric field induced by the time-varying magnetic field outputting the specific rhythm with inherent oscillation rhythms of specific types of nerve cells.

Description

Transcranial magnetic stimulation nerve regulation device and method of use thereof TECHNICAL FIELD

[0001] The present application belongs to the technical field of transcranial magnetic stimulation nerve regulation, and particularly relates to a transcranial magnetic stimulation nerve regulation device and a method of use thereof. BACKGROUND

[0002] Sleep is a brain function state different from the state of wakefulness, and sleep has different stages, including rapid eye movement and non-rapid eye movement, and the non-rapid eye movement is further divided into deep sleep and light sleep. How to increase the duration and proportion of deep sleep, and how to change the light sleep state into deep sleep state, have important value for improving brain health and treating brain diseases, and are a long-term research topic in the scientific community. There is no prior art and method that has been verified to be effective. SUMMARY

[0003] Therefore, the present application aims at the deficiencies of the prior art, and provides a transcranial magnetic stimulation nerve regulation device and a method of use thereof, so as to increase the duration and proportion of deep sleep, improve sleep quality, and improve brain function, prevent and treat brain diseases.

[0004] To achieve the above-mentioned purpose, the present application adopts the following technical solutions:

[0005] A transcranial magnetic stimulation nerve regulation device comprises a sleep tracker and a time-varying magnetic field generator, the sleep tracker is used to collect signals of physiological signs of a human body during sleep, and the time-varying magnetic field generator controls the output of a time-varying magnetic field according to the signals collected by the sleep tracker.

[0006] The sleep tracker comprises a sign collection module and an algorithm module, the sign collection module is used to collect signals of physiological signs of a human body during sleep, and the algorithm module analyzes and processes the signals collected by the sign collection module to obtain sleep state information.

[0007] The sleep state information includes a wake-up period, a rapid eye movement period, a light sleep period or a deep sleep period in which the human body is currently located.

[0008] In order to better realize the present application, the time-varying magnetic field of the time-varying magnetic field generator is further optimized in the above structure, and the strength of the time-varying magnetic field induced electric field is less than 70T / s.

[0009] In order to better realize the present application, the sign collection module is further optimized in the above structure, and the sign collection module is a pressure sensor.

[0010] In order to better realize the present application, the pressure sensor is further optimized in the above structure, and the pressure sensor is a piezoelectric sensor or a piezoresistive sensor.

[0011] In order to better realize the present application, the sign acquisition module further comprises an electromyographic sensor in the above structure.

[0012] In order to better realize the present application, the above structure is further optimized to further comprise a remote server, the remote server is wirelessly connected with the sleep tracker, and the remote server can control the output of the time-varying magnetic field of the time-varying magnetic field generator according to the signals collected by the sleep tracker.

[0013] A use method of the transcranial magnetic stimulation nerve regulation device, comprising the following steps:

[0014] S1, obtaining the collected sleep state information;

[0015] S2, according to the obtained sleep state information, the time-varying magnetic field generator outputs the time-varying magnetic field with preset parameters at the beginning or end of the preset sleep state in the preset time period, and the preset parameters of the time-varying magnetic field include the carrier frequency, the single wave pulse width, the rhythm formed by the string length and the empty time length, and the intermittent output characteristics.

[0016] In order to better realize the present application, the above structure is further optimized, the carrier frequency is 1000-20000Hz, the single wave pulse width is 50-400 microseconds, the rhythm is 1-100Hz, and the typical intermittent characteristics are output 2 seconds and stop 8 seconds.

[0017] In order to better realize the present application, the above structure is further optimized, the carrier frequency is 2500Hz, and the rhythm is 40Hz.

[0018] In order to better realize the present application, the above structure is further optimized, the preset time period is between 0 and 6 o'clock, the preset sleep state is the beginning of light sleep in the second or third or fourth sleep cycle in this time period, or the beginning of deep sleep in the first or second or third sleep cycle in this time period, or the beginning of rapid eye movement period in the third or fourth or fifth sleep cycle in this time period.

[0019] Compared with the prior art, the present application has the following beneficial effects:

[0020] 1. The transcranial magnetic stimulation nerve regulation device provided by the present application can regulate nerve cells by collecting sign information of a user in a sleep state and controlling the time-varying magnetic field generator to output a magnetic field to the brain, can improve the functional activity of inhibitory interneurons, and can achieve the purposes of increasing the duration and proportion of deep sleep, or guiding rapid eye movement period or light sleep period into deep sleep, and improving brain function and preventing and treating brain diseases.

[0021] 2.The method for using the transcranial magnetic stimulation nerve regulation device provided by the application comprises the following steps: acquiring body sign information of a user in a sleep state, and causing a time-varying magnetic field generator to output a time-varying magnetic field with preset parameters at the beginning or end of a preset sleep state in a preset time period, so that the electric field induced by the output time-varying magnetic field with a specific rhythm is coupled with the inherent oscillation rhythm of a specific type of nerve cell to realize the regulation of the function of the nerve cell, thereby guiding the user to enter a deep sleep state in a light sleep stage in a certain time period, or inducing the user to enter a rapid eye movement sleep stage from a non-rapid eye movement sleep stage, and improving the sleep quality. BRIEF DESCRIPTION OF DRAWINGS

[0022] In order to more clearly illustrate the technical solutions in the embodiments of the present application or the prior art, the following will briefly introduce the drawings needed to be used in the embodiments or the prior art description. Obviously, the drawings in the following description are only some embodiments of the present application, and for those skilled in the art, other drawings can also be obtained without creative labor.

[0023] Fig. 1 is a circuit control diagram of the transcranial magnetic stimulation nerve regulation device of the present application;

[0024] Fig. 2 is a fluctuation diagram of the whole night sleep state of a user after using the method for using the transcranial magnetic stimulation nerve regulation device of the present application;

[0025] Fig. 3 is a fluctuation diagram of the whole night sleep state of a menopausal user before using the device;

[0026] Fig. 4 is a fluctuation diagram of the whole night sleep state of a menopausal user after using the device for a period of time;

[0027] Fig. 5 is a fluctuation diagram of the whole night sleep state of a menopausal user after long-term use of the device.

[0028] In the drawings: 1-sleep tracker, 101-body sign acquisition module, 102-algorithm module, 2-time-varying magnetic field generator, 3-remote server. DETAILED DESCRIPTION

[0029] In order to make the purpose, technical solutions and advantages of the present application more clear, the technical solutions of the present application will be described in detail below. Obviously, the described embodiments are only some of the embodiments of the present application, not all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor are within the scope of protection of the present application.

[0030] In the description of the present application, it should be noted that, unless otherwise specified, the meaning of "a plurality of" is two or more; the orientations or positional relationships indicated by the terms "upper", "lower", "left", "right", "inner", "outer", "front end", "rear end", "head", "tail" and the like are based on the orientations or positional relationships shown in the drawings, and are only for the purpose of facilitating the description of the present application and simplifying the description, and are not intended to indicate or imply that the devices or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as limiting the present application. In addition, the terms "first", "second", "third" and the like are only for descriptive purposes and cannot be understood as indicating or implying relative importance.

[0031] In the description of the present application, it should be noted that, unless otherwise specified and limited, the terms "mounting", "connecting", "connection" should be understood broadly, for example, it can be fixed connection, or detachable connection, or integrally connected; it can be mechanical connection, or electrical connection; it can be directly connected, or indirectly connected through an intermediate medium. For those skilled in the art, the specific meaning of the above terms in the present application can be understood according to the specific circumstances.

[0032] Referring to FIG. 1, the transcranial magnetic stimulation nerve regulation device provided by the present application comprises a sleep tracker 1 and a time-varying magnetic field generator 2. The sleep tracker 1 is used to collect physiological sign signals of a human body in a sleep state, and the time-varying magnetic field generator 2 controls the output regulation of the time-varying magnetic field according to the signals collected by the sleep tracker 1. The time-varying magnetic field generator 2 is used to output a time-varying magnetic field. The electric field induced by the specific rhythm of the time-varying magnetic field output can be coupled with the inherent oscillation rhythm of a specific type of nerve cell to achieve regulation of the function of a certain type of nerve cell. The function activity of inhibitory interneurons can be improved, so as to achieve the purpose of increasing the length and proportion of deep sleep, or inducing into rapid eye movement sleep stage in non-rapid eye movement sleep stage, and the like. The brain function is improved, and the brain diseases are prevented and treated.

[0033] The time-varying magnetic field generator 2 is composed of coil components without magnetic cores wound by enameled wire, and the combination of 2 or 3 coil components is a preferred scheme. The arrangement design of the coil components enables the time-varying magnetic field generated thereby to have approximately uniform intensity distribution in the target region matching the size of the brain (for details, please refer to CN111867675B). The intensity of the time-varying magnetic field induced electric field of the time-varying magnetic field generator 2 is lower than 70T / s. The time-varying magnetic field generator acts on the whole brain of a human being, and the time-varying magnetic field is approximately uniformly distributed or weakly gradient distributed in the whole human brain including deep brain regions.

[0034] The sleep tracker 1 comprises a physical sign acquisition module 101 and an algorithm module 102, the physical sign acquisition module 101 is a pressure change or impact force sensitive sensor, the pressure sensor is a piezoelectric sensor or a piezoresistive sensor, signals such as heartbeat, respiration, and body turning of a person in bed can be acquired, and the physical sign acquisition module 101 is additionally provided with an electromyography sensor for improving the sleep state analysis accuracy of the sleep tracker 1. The algorithm module 102 analyzes and processes analog signals acquired by the physical sign acquisition module 101 to obtain sleep state information, and the sleep state information mainly includes a clear period, a rapid eye movement period, a light sleep period, or a deep sleep period in which a human body is currently located, and different time-varying magnetic fields are output at different time points according to the sleep state of a user to improve sleep quality.

[0035] The remote server 3 is further included, the remote server 3 is wirelessly connected with the sleep tracker 1, the functions of the algorithm module 102 can also be realized by the remote server 3, the remote server 3 can control the time-varying magnetic field generator 2 to output the change of the magnetic field according to the signals acquired by the sleep tracker 1, the sleep state of a user can also be monitored in real time through the remote server 3, when it is found that a user cannot normally enter deep sleep, the remote server 3 remotely controls the time-varying magnetic field generator 2 to output a time-varying magnetic field in the REM rapid eye movement period, guides the user to enter deep sleep, and improves sleep quality, compared with relying on the system of the time-varying magnetic field generator 2 to intervene according to the sleep state of a user, the real-time monitoring and control of the remote server 3 are adopted, the guiding process is more accurate, and the output conditions and time-varying magnetic field parameters can also be adjusted in time according to the characteristics of a user.

[0036] In use, the sleep tracker 1 and the time-varying magnetic field generator 2 are placed on a bed or under a pillow, can output a time-varying magnetic field with a weak intensity and a rhythm that can reach a deep brain to act on a human brain during sleep of a user, thereby providing an effective intervention means for improving sleep quality and further improving brain health of a user.

[0037] A use method of the transcranial magnetic stimulation nerve regulation device, comprising the following steps:

[0038] S1, acquiring sleep state information acquired by the sleep tracker 1.

[0039] S2, according to the obtained sleep state information, at the beginning or end of the preset sleep state in the preset time period, the time-varying magnetic field generator 2 outputs the time-varying magnetic field with preset parameters, and the preset parameters of the time-varying magnetic field include carrier frequency, single wave pulse width, rhythm formed by string length and empty time length, and intermittent output characteristics. Wherein, the carrier frequency range is 1000-20000Hz, preferably 2500Hz, the single wave pulse width is 100-400 microseconds, the rhythm formed by the string length and the empty time length is 1-100Hz, preferably 40Hz, and the typical intermittent characteristics are output for 2 seconds and stop for 8 seconds. When the appropriate parameter time-varying magnetic field coupled with the inherent oscillation rhythm of the inhibitory interneuron is applied to the brain during sleep, the function activity of the inhibitory interneuron can be better improved.

[0040] The preset time period is between 0-6 o'clock, and the preset sleep state is the beginning of the second or third or fourth sleep cycle light sleep in this time period, or the beginning of the first or second or third sleep cycle deep sleep in this time period, or the beginning of the third or fourth or fifth sleep cycle rapid eye movement period in this time period.

[0041] At the beginning or end of the preset sleep state in the preset time period, the time-varying magnetic field generator 2 outputs the time-varying magnetic field with preset parameters. For example, when the user enters the fourth light sleep, the time-varying magnetic field generator starts to work with preset parameters; or when the user enters the second light sleep, the time-varying magnetic field generator works with preset parameters every time the user enters light sleep and works not more than 5 times a night; or when the user enters the fourth rapid eye movement sleep period, the time-varying magnetic field generator starts to work with preset parameters, and different output parameters are set according to the sleep state of the user.

[0042] For the case that the preset parameters do not meet the standard due to poor sleep state and irregular work and rest of the user, the remote server 3 monitors the sleep fluctuation of the user in real time, formulates targeted preset parameters according to different conditions, improves the applicability of the user, and formulates appropriate time-varying magnetic field parameters for the user.

[0043] The rhythmic, deep brain-reachable, weak intensity transcranial magnetic stimulation is expected to improve brain health and treat brain diseases by outputting magnetic fields with appropriate parameters to regulate the function activity of inhibitory interneurons in the whole brain including deep brain regions. Because this kind of magnetic stimulation is realized by coupling the output specific rhythm time-varying magnetic field induced electric field with the inherent oscillation rhythm of specific type of nerve cells to regulate the function of certain type of nerve cells, therefore, what parameters of magnetic field to output, what part to output to (such as whether it can act on deep brain regions), and what time to output are very important. The preset parameters of the time-varying magnetic field include carrier frequency, magnetic induction pulse electric field intensity, single wave pulse width, rhythm formed by string length and empty time length, and intermittent output characteristics.

[0044] Referring to Fig. 2, the test user is set to work the time-varying magnetic field generator at the 4th light sleep stage after 0 o'clock, outputting a 30-minute gamma rhythm magnetic field. As a result, the user immediately entered a deep sleep state after the time-varying magnetic field generator 2 was working, and then entered a deep sleep state automatically and continuously (without magnetic stimulation) multiple times, with the total deep sleep time of the whole night being 1.5 hours, 50% more than the usual 1 hour. The arrow in the figure points to the time when the time-varying magnetic field generator 2 starts to output the magnetic field, and the ellipse encloses the three consecutive deep sleep stages that follow.

[0045] Referring to Figs. 3-5, the sleep state fluctuation graphs of a certain menopausal user before and after using the device are shown. As shown in Fig. 3, the user's sleep state is difficult to fall asleep, wake up early, and difficult to fall asleep again, which is a typical sleep structure state of menopausal women. After using the device for a period of time, the user's sleep state is shown in Fig. 4, and the user will wake up once in the middle of the night, but can fall asleep again quickly after returning to bed, and the overall sleep quality has been significantly improved. Finally, as shown in Fig. 5, after long-term use of the device, the user can achieve a complete sleep process of 7-8 hours throughout the night, which shows that the device has a long-term helping effect on the user's sleep and has a significant positive effect.

[0046] The above is only a specific embodiment of the present application, but the protection scope of the present application is not limited thereto. Any skilled person in the art can easily think of changes or replacements within the technical scope disclosed by the present application, which should be covered within the protection scope of the present application. Therefore, the protection scope of the present application should be subject to the protection scope of the claims.

Claims

A transcranial magnetic stimulation nerve regulation device, characterized in that: The device comprises a sleep tracker (1) for collecting signals of physiological signs of a human body during sleep and a time-varying magnetic field generator (2) for controlling output of a time-varying magnetic field according to the signals collected by the sleep tracker (1). The sleep tracker (1) comprises a sign collection module (101) for collecting signals of physiological signs of a human body during sleep and an algorithm module (102) for analyzing and processing the signals collected by the sign collection module (101) to obtain sleep state information. The sleep state information comprises a real-time wake period, a rapid eye movement period, a light sleep period or a deep sleep period of the human body. The transcranial magnetic stimulation neuromodulation device according to claim 1, characterized in that: The time-varying magnetic field generator (2) has a time-varying magnetic field induced electric field with a strength less than 70 T / s. The transcranial magnetic stimulation neuromodulation device according to claim 1, characterized in that: The sign collection module (101) is a pressure sensor. The transcranial magnetic stimulation neuromodulation device according to claim 3, characterized in that: The pressure sensor is a piezoelectric sensor or a piezoresistive sensor. The transcranial magnetic stimulation neuromodulation device according to claim 4, characterized in that: The sign collection module (101) further comprises an electromyographic sensor. The transcranial magnetic stimulation neuromodulation device according to claim 1, characterized in that: The device further comprises a remote server (3) wirelessly connected to the sleep tracker (1), which can control the output of the time-varying magnetic field of the time-varying magnetic field generator (2) according to the signals collected by the sleep tracker (1). A method of using a transcranial magnetic stimulation neuromodulation device as defined in claim 1, characterized in that: The device comprises the following steps: S1, obtaining the collected sleep state information; S2, according to the obtained sleep state information, causing the time-varying magnetic field generator (2) to output a time-varying magnetic field with preset parameters at the beginning or end of a preset sleep state in a preset time period, wherein the preset parameters of the time-varying magnetic field include carrier frequency, single wave pulse width, rhythm formed by string length and idle time length, and intermittent output characteristics. The use according to claim 7, characterized in that The carrier frequency is 1000-20000 Hz, the single wave pulse width is 50-400 microseconds, the rhythm is 1-100 Hz, and the typical intermittent characteristics are output for 2 seconds and stop for 8 seconds. The use according to claim 8, characterized in that The carrier frequency is 2500 Hz, and the rhythm is 40 Hz. The use according to claim 7, characterized in that The preset time period is between 0 and 6 o'clock, and the preset sleep state is the beginning of light sleep in the second or third or fourth sleep cycle in this time period, or the beginning of deep sleep in the first or second or third sleep cycle in this time period, or the beginning of the rapid eye movement period in the third or fourth or fifth sleep cycle in this time period.

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