Water-soluble enteric resin medicine multi-dosage form adaptive high-efficiency coating pan

Abstract

The present application relates to the field of pharmaceutical equipment, and discloses a water-soluble enteric resin medicine multi-dosage form adaptive efficient coating pan, aiming at solving the problems of poor coating uniformity and low drying efficiency of the existing related equipment; the coating pan comprises an airtight tank, a rotary coating pan is arranged in the tank, and helical stirring blades are arranged on the inner wall of the rotary coating pan; a diaphragm vacuum pump and a servo motor are mounted on the bottom of the tank, the servo motor can drive the rotary coating pan to rotate and the diaphragm vacuum pump to operate to form a negative pressure environment, a metal feeding pipe is penetrated through the sealing cover at the top of the tank, a coating material pipe and a hot air pipe are integrated in the metal feeding pipe, a double-channel electromagnetic valve and an air heating tank are connected outside, symmetrical coating material injection pipes and hot air injection pipes are arranged on the side of the metal feeding pipe, and the ends of the pipes are all fan-shaped nozzles, and stirring rods are further arranged at the lower ends of the pipes; the equipment is adaptive to various medicine dosage forms, can improve the coating uniformity and drying efficiency, and has the advantages of energy saving.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of pharmaceutical equipment, in particular to a water-soluble enteric resin drug multi-dosage form adaptive high-efficiency coating pan. BACKGROUND

[0002] In the production of pharmaceutical preparations, especially when coating drugs, the uniformity, efficiency and adaptability to different dosage forms of the coating are key indicators to measure the performance of the coating equipment. Traditional drug coating equipment, such as rotary pan coater or fluidized bed coater, often faces some problems when processing water-soluble enteric resin drugs.

[0003] The existing coating pan has deficiencies in the synergistic effect of vacuum degree and hot air. Some equipment only emphasizes high-temperature rapid drying, but ignores the promotion effect of vacuum environment on water evaporation rate and the influence of uniform distribution of hot air on drying effect. After the coating liquid is sprayed, if the water vapor cannot be quickly and uniformly removed, a high-humidity environment may be formed in the local area, which may further cause defects in the coating layer. In addition, the mixing and turning effect of the tablets, granules or pellets in the equipment is not good, which further limits the uniformity and drying efficiency of the coating, for example, some equipment simply relies on the rotation of the pan body, but lacks effective stirring structure inside, so that the drugs in the lower layer cannot be fully contacted with the coating material and hot air, resulting in uneven coating. SUMMARY

[0004] The technical problem to be solved by the present application is that the existing water-soluble enteric resin drug coating equipment has the disadvantages of poor coating uniformity and low drying efficiency. Therefore, the present application provides a water-soluble enteric resin drug multi-dosage form adaptive high-efficiency coating pan.

[0005] To achieve the above purpose, the following technical scheme is adopted in the present application: a water-soluble enteric resin drug multi-dosage form adaptive high-efficiency coating pan, comprising: a gas-tight tank, which is a conical sealed cavity, and the inner wall thereof is provided with a corrosion-resistant coating; a rotary coating pan is rotatably connected in the gas-tight tank through a bearing assembly, and the sidewall of the pan body of the rotary coating pan is provided with dense micropores with a pore size of 0.1-1mm and a porosity of 30%-50%; a diaphragm vacuum pump is fixedly installed at the bottom center of the gas-tight tank, and the air outlet end of the diaphragm vacuum pump is in sealed communication with the inside of the gas-tight tank; a servo motor is fixedly connected to the bottom of the diaphragm vacuum pump through a flange, the drive shaft of the servo motor extends along the axial direction and is drivingly connected to a connecting main shaft through a shaft coupling, the connecting main shaft penetrates the central shaft hole of the diaphragm vacuum pump and is fixedly connected to the bottom center of the rotary coating pan, and a mechanical seal is arranged between the connecting main shaft and the shaft hole of the diaphragm vacuum pump;

[0006] The sealing cover is detachably connected to the top opening of the airtight tank through a sealing ring, a metal feeding pipe vertically penetrates the center of the sealing cover, and the metal feeding pipe is fixed and sealed to the sealing cover through welding; a coating material pipe and a hot air pipe are arranged in parallel along the axial direction of the metal feeding pipe, the input ends of the coating material pipe and the hot air pipe extend outside the sealing cover and are jointly connected to a double-channel electromagnetic valve; the input end of the hot air pipe is in sealed communication with the air outlet end of the air heating tank through a pipeline; the metal feeding pipe is fixedly connected to at least three coating material injection pipes along the radial direction on one side of the side wall in the airtight tank, the input end of the coating material injection pipe is in sealed communication with the output end of the coating material pipe; the metal feeding pipe is fixedly connected to at least three hot air injection pipes along the radial direction on the other side of the side wall, the input end of the hot air injection pipe is in sealed communication with the output end of the hot air pipe; the lower end of the metal feeding pipe in the airtight tank is also fixedly connected to at least two stirring rods.

[0007] Further, the rotary coating pot is inverted conical, and the conical angle is 60°-120°; the inner wall of the rotary coating pot is uniformly fixedly connected with helical stirring blades along the generatrix direction, and the helical direction of the helical stirring blades is adapted to the rotating direction of the rotary coating pot.

[0008] Further, the diaphragm vacuum pump is uniformly distributed with four independent working cavities along the circumferential direction, each working cavity is provided with a one-way air suction valve at the top, and the diaphragm vacuum pump is in communication with the inside of the airtight tank through the one-way air suction valve; each working cavity is provided with a one-way air exhaust valve at the bottom, and the one-way air exhaust valve is in communication with the outside atmosphere; the working cavity is sealingly provided with an elastic diaphragm made of aging-resistant rubber material; the output shaft end of the servo motor is fixedly connected with an eccentric shaft, four groups of push-pull connecting rods are rotatably connected to the eccentric part of the eccentric shaft through bearings, and the other ends of each group of push-pull connecting rods are rotatably connected to the center positions of the elastic diaphragms in the corresponding working cavities.

[0009] Further, the coating material pipe and the hot air pipe both penetrate the inside of the metal feeding pipe along the axial direction of the metal feeding pipe, and are arranged in parallel; heat-conducting silicone grease is arranged between the coating material pipe, the hot air pipe and the inner wall of the metal feeding pipe.

[0010] Further, the coating material pipe, the hot air pipe and the metal feeding pipe are all made of red copper material, and the inner wall of the coating material pipe is provided with a polytetrafluoroethylene anti-sticking coating.

[0011] Further, the double-channel electromagnetic valve includes two independent electromagnetic control valve bodies, which are respectively connected to the input ends of the coating material pipe and the hot air pipe to independently control the feeding flow of the coating material pipe and the air inflow of the hot air pipe, and the control precision is ±5%.

[0012] Further, the air heating tank comprises a double-layer heat insulation tank body, the inner layer of the heat insulation tank body is made of stainless steel material, and the outer layer is a heat preservation material layer; one end of the heat insulation tank body is provided with an air inlet, and an air inlet filter screen is fixedly installed at the air inlet; the air inlet filter screen is a HEPA filter screen; the other end of the heat insulation tank body is provided with an air outlet and is in sealed communication with the hot air pipe through a pipeline; and helical electric heating wires are uniformly distributed in the heat insulation tank body along the airflow direction, the power of the electric heating wires is adjustable, and the heating temperature range is 30-80 DEG C.

[0013] Further, the coating material spraying pipe is perpendicular to the axis of the metal feeding pipe and is spaced apart along the axial direction of the metal feeding pipe; four coating material spraying pipes are arranged, the lengths of the four coating material spraying pipes decrease from top to bottom, and the length difference between adjacent two coating material spraying pipes is 5-10 mm; the end of each coating material spraying pipe is provided with a fan-shaped nozzle, the spraying angle of the nozzle is 45 DEG -60 DEG, and the shortest distance from the outlet end of all the nozzles to the inner wall of the rotary coating pot is uniform and is 10-30 mm.

[0014] Further, the hot air spraying pipe is perpendicular to the axis of the metal feeding pipe and is spaced apart along the axial direction of the metal feeding pipe; four hot air spraying pipes are arranged, the lengths of the four hot air spraying pipes decrease from top to bottom, and the length difference between adjacent two hot air spraying pipes is 5-10 mm; the end of each hot air spraying pipe is provided with a fan-shaped nozzle, the aperture of the nozzle is 2-5 mm, and the shortest distance from the outlet end of all the nozzles to the inner wall of the rotary coating pot is uniform and is 10-30 mm.

[0015] Further, the coating material spraying pipe and the hot air spraying pipe are symmetrically arranged on the front and back sides of the metal feeding pipe along the axis of the metal feeding pipe, the spraying directions of the coating material spraying pipe and the hot air spraying pipe are opposite, and stirring rods are symmetrically arranged on the left and right sides of the metal feeding pipe.

[0016] Technical effects and advantages of the present application:

[0017] 1. The centrifugal force of the rotary coating pot in the present application makes the medicine chips uniformly dispersed and spread on the conical inner wall, and the design of the micropores of the pot body is beneficial to the adhesion of the coating material and the uniform penetration of the hot air; in addition, the spiral stirring blades and the fixed stirring rods can effectively stir and mix the medicine, prevent accumulation and adhesion, and ensure the uniformity of the coating of different dosage forms, especially small-size medicines such as micro-pellets; at the same time, the symmetrical staggered arrangement of the coating material spraying pipe and the hot air spraying pipe and the fan-shaped design of the nozzles ensure that the coating material and the hot air can fully and uniformly cover the surface of the medicine, avoiding dead angles.

[0018] 2. The application forms a negative pressure environment by vacuumizing the inside of the airtight tank through the diaphragm vacuum pump, significantly reduces the boiling point of water, accelerates the evaporation rate of moisture in the coating material, and improves the drying efficiency; at the same time, the air heating tank provides precise temperature control hot air, which is directly heated and dried to the drug coating through the hot air injection pipe, and makes the hot air penetrate the drug layer, so as to realize efficient drying.

[0019] 3. The metal feeding pipe of the application is integrated with the coating material pipe and the hot air pipe, and heat transfer is carried out through the heat-conducting silicone grease, so that the hot air preheats the coating material, helps to maintain the temperature stability of the coating material, prevents nozzle blockage, and improves the spraying effect; at the same time, the double-channel electromagnetic valve integrates the control of the coating material and the hot air, simplifying the pipeline layout; in addition, the vacuum drying technology reduces the temperature required for drying, and the use of the heat-insulating tank body reduces heat loss; the preheating of the coating material in the coating material pipe by the hot air also utilizes heat energy, improving the overall energy utilization efficiency. BRIEF DESCRIPTION OF DRAWINGS

[0020] The disclosure of the application will be described with reference to the accompanying drawings. It should be understood that the drawings are only for illustrative purposes, and are not intended to limit the scope of protection of the application. In the drawings, the same reference numerals are used to refer to the same parts:

[0021] Figure 1 is a schematic diagram of the appearance structure of the application;

[0022] Figure 2 is a schematic diagram of the opening structure of the sealing cover of the application;

[0023] Figure 3 is a schematic diagram of the cross-sectional structure of the application Figure 1 ;

[0024] Figure 4 is a schematic diagram of the cross-sectional structure of the application Figure 2 ;

[0025] Figure 5 is a schematic diagram of the metal feeding pipe structure of the application;

[0026] Figure 6 is a schematic diagram of the cross-sectional structure of the air heating tank of the application;

[0027] Figure 7 is a schematic diagram of the Figure 4 enlarged structure at A of the application;

[0028] Figure 8 is a schematic diagram of the cross-sectional structure of the metal feeding pipe of the application.

[0029] Legend: 1, air-tight tank; 2, rotary coating pot; 3, spiral stirring blade; 4, diaphragm vacuum pump; 401, working cavity; 402, one-way air suction valve; 403, one-way air exhaust valve; 404, elastic diaphragm; 405, eccentric shaft; 406, push-pull connecting rod; 5, servo motor; 6, connecting main shaft; 7, sealing cover; 8, metal feeding pipe; 9, coating material pipe; 10, hot air pipe; 11, double-channel electromagnetic valve; 12, air heating tank; 1201, heat insulation tank body; 1202, air inlet filter screen; 1203, air outlet; 1204, electric heating wire; 13, coating material injection pipe; 14, hot air injection pipe; 15, stirring rod. DETAILED DESCRIPTION

[0030] The technical solutions in the present application will be described in detail below with reference to the drawings in the present application. Obviously, the described embodiments are only a part of the embodiments of the present application, rather than all the embodiments. The components of the present application described and shown in the drawings herein can be arranged and designed in various different configurations. Therefore, the following detailed description of the embodiments of the present application provided in the drawings is not intended to limit the scope of the present application, but only represents selected embodiments of the present application. Based on the embodiments of the present application, all other embodiments obtained by those skilled in the art without creative labor are within the scope of protection of the present application. It should be noted that: similar reference numerals and letters represent similar items in the following drawings, so once an item is defined in one drawing, it does not need to be further defined and explained in subsequent drawings. Meanwhile, in the description of the present application, the terms "first", "second", etc. are only used for differentiation in description, and cannot be understood as indicating or implying relative importance. EMBODIMENT

[0031] Please refer to Figure 1 Figure 8 The present application provides a water-soluble enteric-coated resin drug multi-dose form adaptive high-efficiency coating pot, which mainly comprises an air-tight tank 1, a rotary coating pot 2, a diaphragm vacuum pump 4, a servo motor 5, a connecting main shaft 6, a sealing cover 7, a metal feeding pipe 8, a coating material pipe 9, a hot air pipe 10, a double-channel electromagnetic valve 11, an air heating tank 12, a coating material injection pipe 13, a hot air injection pipe 14, and a stirring rod 15.

[0032] The air-tight tank 1 is a conical sealed cavity, and the inner wall thereof is provided with a corrosion-resistant coating to prevent chemical substances from corroding the inside of the tank during coating, thereby ensuring the service life of the equipment and the purity of the drug. The conical sealed cavity provides a stable low-pressure or even vacuum environment.

[0033] ​Inside the air-tight tank 1, a rotary coating pot 2 is connected by bearing assembly, the rotary coating pot 2 is the core component for containing medicine for coating treatment, the side wall of the pot body is provided with dense micropores, the aperture of the micropores is 0.1-1mm, and the porosity is 30%-50%, the aperture and porosity in the range are designed to make the hot air uniformly penetrate the medicine layer in the pot and effectively discharge the water vapor generated in the coating process, while preventing the medicine particles from escaping from the micropores.

[0034] A diaphragm vacuum pump 4 is fixedly installed at the bottom center of the air-tight tank 1, the air suction end of the diaphragm vacuum pump 4 is in sealed communication with the inside of the air-tight tank 1, responsible for sucking out the air in the air-tight tank 1 to form a negative pressure environment, thereby accelerating the evaporation of moisture; the diaphragm vacuum pump 4 is fixedly connected with a servo motor 5 at the bottom through a flange, the driving shaft of the servo motor 5 extends along the axial direction and is drivingly connected with a connecting main shaft 6 through a shaft coupling; the connecting main shaft 6 penetrates the center shaft hole of the diaphragm vacuum pump 4 and is fixedly connected with the bottom center of the rotary coating pot 2; the servo motor 5 drives the connecting main shaft 6 to rotate the rotary coating pot 2; in order to ensure the sealing of the air-tight tank 1, a mechanical seal is arranged between the connecting main shaft 6 and the shaft hole of the diaphragm vacuum pump 4, which effectively prevents external air from entering and maintains the vacuum state in the tank.

[0035] A sealing cover 7 is detachably connected to the top opening of the air-tight tank 1 through a sealing ring, which facilitates the cleaning, maintenance, loading and unloading of the medicine inside the air-tight tank 1; a metal feeding pipe 8 vertically penetrates the center of the sealing cover 7, and is fixed and sealed between the sealing cover 7 by welding, ensuring the sealing and structural stability.

[0036] The metal feeding pipe 8 is provided with a coating material pipe 9 and a hot air pipe 10 parallel along the axial direction inside, the coating material pipe 9 is used for conveying coating liquid, and the hot air pipe 10 is used for conveying dry hot air; the input ends of the coating material pipe 9 and the hot air pipe 10 are both extended outside the sealing cover 7 and are jointly connected with a double-channel electromagnetic valve 11, which is used for independently controlling the flow of coating material and hot air. The input end of the hot air pipe 10 is in sealed communication with the air outlet end of an air heating tank 12 through a pipeline, and the air heating tank 12 is used for filtering and heating the entering hot air.

[0037] The metal feeding pipe 8 is fixedly connected with at least three coating material spraying pipes 13 on one side of the side wall inside the air-tight tank 1 along the radial direction, the input ends of the coating material spraying pipes 13 are in sealed communication with the output end of the coating material pipe 9, responsible for uniformly spraying the coating material to the surface of the medicine in the rotary coating pot 2; the other side of the side wall of the metal feeding pipe 8 is fixedly connected with at least three hot air spraying pipes 14 along the radial direction, the input ends of the hot air spraying pipes 14 are in sealed communication with the output end of the hot air pipe 10, used for spraying the heated hot air to the medicine to accelerate drying.

[0038] In order to further improve the mixing uniformity of the medicine, the lower end of the metal feeding pipe 8 inside the air-tight tank 1 is also symmetrically fixedly connected with at least two stirring rods 15, which remain relatively static when the rotary coating pan 2 rotates, and generate relative motion with the rotating medicine, thereby effectively stirring the medicine, preventing agglomeration and adhesion, and ensuring the uniformity of the coating.

[0039] In use of the coating pan, first, the medicine chips are poured into the rotary coating pan 2, then the sealing cover 7 is covered, and the coating material pipe 9 is connected with the container containing the coating material. After preparation, the servo motor 5 is started to drive the rotary coating pan 2 to rotate. When the rotary coating pan 2 rotates, the medicine chips are uniformly dispersed on the conical inner wall of the rotary coating pan 2 by centrifugal force, and at the same time, the servo motor 5 also drives the diaphragm vacuum pump 4 to pump the air in the air-tight tank 1 outwards, so that the air pressure in the air-tight tank 1 is lower than the outside atmospheric pressure to form a vacuum. At this time, the double-channel electromagnetic valve 11 opens the communication of the coating material pipe 9 and the hot air pipe 10, so that the outside atmospheric pressure will push the coating material from the coating material pipe 9 into the metal feeding pipe 8, and then uniformly sprayed from the coating material spraying pipe 13 and covered on the surface of the medicine chips. At the same time, the outside air is also pumped in, and the air is filtered and heated by the air heating tank 12 and then sprayed from the hot air spraying pipe 14 opposite to the coating material spraying pipe 13 to heat and dry the medicine coating. At the same time, the spiral stirring blade 3 rotates with the rotary coating pan 2, and cooperates with the fixed stirring rod 15 to stir the medicine, so that it is more uniform. Subsequently, the hot air with steam enters the air-tight tank 1 through the micropores on the rotary coating pan 2, and is then pumped out by the diaphragm vacuum pump 4. The conical shape of the rotary coating pan 2 and the micropores arranged thereon enable the medicine to be uniformly dispersed and spread when the rotary coating pan 2 rotates, which is conducive to the adhesion and drying of the coating. After the hot air is blown out, it will pass through the pores between the medicine chips and then flow out through the micropores on the rotary coating pan 2, so that the drying effect is more thorough and uniform. Embodiment

[0040] On the basis of embodiment 1, the structure of the rotary coating pan 2 and the stirring effect are further optimized in this embodiment.

[0041] Please refer to Figure 3 and Figure 4 , the rotary coating pan 2 is inverted conical, and the cone angle is 60°-120°. The inverted conical design enables the medicine to be better dispersed and rolled under the joint action of centrifugal force and gravity during rotation, avoids the medicine from being accumulated at the bottom or edge of the pan, ensures the uniformity of the coating, and maximizes the coating area while ensuring sufficient rolling of the medicine.

[0042] More preferably, the inner wall of the rotary coating pan 2 is uniformly fixedly connected with helical stirring blades 3 along the generatrix direction, the helical direction of the helical stirring blades 3 is adapted to the rotation direction of the rotary coating pan 2, when the rotary coating pan 2 rotates, the helical stirring blades 3 can effectively lift the medicine at the bottom of the pan upward, and make the upper medicine descend to the bottom of the pan, thereby realizing sufficient mixing and turning in three-dimensional directions, greatly enhancing the relative movement between the medicine particles, ensuring that each medicine can be in full contact with the coating material and hot air, further improving the uniformity and drying efficiency of the coating. This active stirring combined with passive centrifugal force dispersion enables the coating pan to efficiently adapt to various dosage forms of medicines, including micro-pellets and particles that are prone to accumulate. Embodiments

[0043] Based on the embodiments 1 or 2, this embodiment further refines the structure of the diaphragm vacuum pump 4, the metal feed pipe 8 and its internal pipeline, and the air heating tank 12.

[0044] Please refer to Figure 7 The diaphragm vacuum pump 4 is uniformly distributed with four independent working cavities 401 in the circumferential direction, the top of each working cavity 401 is provided with a one-way air suction valve 402, the diaphragm vacuum pump 4 is in communication with the inside of the air-tight tank 1 through the one-way air suction valve 402, ensuring that it only sucks but does not return; the bottom of each working cavity 401 is provided with a one-way air exhaust valve 403, the one-way air exhaust valve 403 is in communication with the outside atmosphere, used for exhausting the gas sucked by the vacuum pump; the working cavity 401 is sealingly provided with an elastic diaphragm 404, the elastic diaphragm 404 is made of aging-resistant rubber material, which ensures the sealing property and service life of the diaphragm under long-term operation; the output shaft end of the servo motor 5 is fixedly connected with an eccentric shaft 405, the eccentric part of the eccentric shaft 405 is rotatably connected with four groups of push-pull connecting rods 406 through bearings, the other end of each group of push-pull connecting rods 406 is rotatably connected with the center position of the elastic diaphragm 404 in the corresponding working cavity 401; when the servo motor 5 drives the eccentric shaft 405 to rotate, the four elastic diaphragms 404 are driven to reciprocate through the push-pull connecting rods 406, thereby realizing continuous air suction of the inside of the air-tight tank 1 and providing a stable vacuum environment; this multi-chamber diaphragm pump has the advantages of simple structure, stable operation, convenient maintenance and no oil pollution.

[0045] Please refer to Figure 5 and Figure 8The coating material pipe 9 and the hot air pipe 10 are both arranged in the axial direction of the metal feeding pipe 8 and parallel to each other, so that the coating material and the hot air can be delivered through the same path, and the structure is compact; the coating material pipe 9 and the hot air pipe 10 are provided with heat-conducting silicone grease between the inner wall of the metal feeding pipe 8, which can effectively transfer the heat in the hot air pipe 10 to the coating material pipe 9 to preheat the coating material, thereby reducing the viscosity of the coating material, improving the atomization effect, and preventing the coating material from solidifying or clogging the nozzle in a low-temperature environment, especially when processing water-soluble enteric resin drugs, maintaining a suitable temperature is crucial for the coating quality.

[0046] Further, the coating material pipe 9, the hot air pipe 10 and the metal feeding pipe 8 are all made of red copper, which has excellent heat-conducting performance and can better achieve heat transfer, and the inner wall of the coating material pipe 9 is provided with a polytetrafluoroethylene anti-sticking coating, which can effectively prevent the coating material from adhering to the pipe wall during delivery, ensuring smooth flow and reducing cleaning difficulty.

[0047] Please refer to Figure 5 The double-channel electromagnetic valve 11 includes two independent electromagnetic control valve bodies, which are respectively connected with the input ends of the coating material pipe 9 and the hot air pipe 10, and can independently control the feeding flow of the coating material pipe 9 and the air inflow of the hot air pipe 10, with a control accuracy of ±5%, which ensures that the supply amount of the coating material and the hot air can be accurately adjusted according to the process requirements, and the coating process is finely managed, so as to obtain high-quality coating film.

[0048] Please refer to Figure 6 The air heating tank 12 includes a double-layer heat-insulating tank body 1201, the inner layer of which is made of stainless steel, and the outer layer is a heat-insulating material layer; the stainless steel inner layer ensures the corrosion resistance and cleanliness of the tank body, and the heat-insulating material layer effectively reduces heat loss and improves energy efficiency; one end of the heat-insulating tank body 1201 is provided with an air inlet, and an air inlet filter screen 1202 is fixedly installed at the air inlet; the air inlet filter screen 1202 is a HEPA filter screen, which ensures that the incoming hot air meets the cleanliness requirements and avoids secondary pollution to the drugs; the other end of the heat-insulating tank body 1201 is provided with an air outlet 1203, which is in sealed communication with the hot air pipe 10 through a pipeline; the heat-insulating tank body 1201 is uniformly provided with spiral electric heating wires 1204 along the airflow direction, and the power of the electric heating wires 1204 can be adjusted, with a heating temperature range of 30-80℃, which is suitable for the gentle drying of water-soluble enteric resin drugs and prevents damage to the activity of the drugs or the structure of the coating film caused by high temperature, and the adjustable power and spiral distribution ensure uniform heating of the hot air.

[0049] Please refer to Figure 5, the coating material spraying pipes 13 are vertically arranged to the axis of the metal feeding pipe 8 and are distributed along the axial direction of the metal feeding pipe 8, four coating material spraying pipes 13 are arranged, the lengths of the pipes are gradually reduced from top to bottom, the length difference between two adjacent pipes is 5-10mm, so that the coating material spraying can cover the medicine at different height positions in the rotary coating pot 2 and provide more comprehensive spraying; the end of each coating material spraying pipe 13 is provided with a fan-shaped nozzle, the spraying angle of the nozzle is 45-60°, the fan-shaped nozzle can form a wide and thin atomization surface, realize uniform covering of the coating material, and the shortest distance from the outlet end of all nozzles to the inner wall of the rotary coating pot 2 is uniform, which is 10-30mm, so that the medicine at different positions can receive uniform coating material spraying intensity and avoid uneven coating thickness caused by distance difference.

[0050] Please refer to Figure 5 , the hot air spraying pipes 14 are vertically arranged to the axis of the metal feeding pipe 8 and are distributed along the axial direction of the metal feeding pipe 8, four hot air spraying pipes 14 are arranged, the lengths of the pipes are gradually reduced from top to bottom, the length difference between two adjacent pipes is 5-10mm, corresponding to the layout of the coating material spraying pipes 13, to ensure the hot air coverage range, the end of each hot air spraying pipe 14 is provided with a fan-shaped nozzle, the aperture of the nozzle is 2-5mm, the fan-shaped nozzle can form a concentrated hot air flow to effectively dry the medicine area after spraying the coating material, and the shortest distance from the outlet end of all nozzles to the inner wall of the rotary coating pot 2 is uniform, which is 10-30mm, to ensure the uniformity and consistency of the hot air drying.

[0051] Please refer to Figure 5 and Figure 8 , the coating material spraying pipes 13 and the hot air spraying pipes 14 are symmetrically arranged on the front and back sides of the metal feeding pipe 8 along the axis of the metal feeding pipe 8, the spraying directions of the two are opposite, which can form alternating spraying and drying of the medicine, realize the cooperation of coating and drying, avoid interference between the coating material and the hot air, and improve the coating efficiency and quality; the left and right sides of the metal feeding pipe 8 are respectively symmetrically provided with stirring rods 15, a gap of 5-15mm is left between the rotation track of the stirring rod 15 and the inner wall of the rotary coating pot 2, which can ensure that the stirring rod 15 can fully stir the medicine and avoid friction with the inner wall of the rotary coating pot 2, to protect the equipment and prolong the service life, the stirring rod 15 cooperates with the helical stirring blade 3 to significantly enhance the mixing effect of the medicine, to ensure the uniformity of the coating.

[0052] The above only describes the embodiments of the present application and is not used to limit the protection scope of the present application, for those skilled in the art, the present application can have various changes and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. A water-soluble enteric resin drug multi-dosage form adapting high- efficiency coating kettle, characterized in that, The utility model relates to a kind of rotary coating equipment, including: Air-tight tank, the air-tight tank is conical sealed cavity, and the inner wall is equipped with corrosion-resistant coating;Rotary coating pot is rotatably connected in the air-tight tank by bearing assembly, the pot body side wall of the rotary coating pot is equipped with dense micropore, and the rotary coating pot is inverted cone;Spiral stirring blade is uniformly fixedly connected on the inner wall of the rotary coating pot along generatrix direction, and the spiral direction of the spiral stirring blade is compatible with the rotation direction of rotary coating pot;Diaphragm vacuum pump is fixedly installed in the bottom center of the air-tight tank, and the air exhaust end of the diaphragm vacuum pump is sealingly communicated with the inside of air-tight tank;Servo motor is fixedly connected with the flange at the bottom of the diaphragm vacuum pump, the drive shaft of the servo motor extends along the axial direction and is drivingly connected with connecting main shaft through coupling, and the connecting main shaft penetrates the central shaft hole of diaphragm vacuum pump and is fixedly connected with the bottom center of rotary coating pot; Sealing cover is detachably connected at the top opening of the air-tight tank through sealing ring, and metal feeding pipe is vertically penetrated in the center position of the sealing cover, and the metal feeding pipe is fixed and sealed with sealing cover by welding;Coating material pipe and hot air pipe are arranged in parallel along the axial direction in the metal feeding pipe, and the input end of the coating material pipe and hot air pipe is stretched outside sealing cover and is connected with double-channel electromagnetic valve;The input end of the hot air pipe is sealingly communicated with the air outlet end of air heating tank through pipeline;The side wall of the metal feeding pipe is fixedly connected with at least three coating material injection pipes along the radial direction in the inside of air-tight tank, and the input end of the coating material injection pipe is sealingly communicated with the output end of the coating material pipe;The side wall of the metal feeding pipe is fixedly connected with at least three hot air injection pipes along the radial direction on the other side, and the input end of the hot air injection pipe is sealingly communicated with the output end of the hot air pipe;The lower end of the metal feeding pipe is also fixedly connected with at least two stirring rods in the inside of air-tight tank.

2. The water-soluble enteric resin pharmaceutical multi-dosage form adapting high- efficiency coating kettle according to claim 1, characterized in that, Four independent working cavities are uniformly distributed in the diaphragm vacuum pump along the circumferential direction, and each working cavity is provided with one-way air suction valve at the top, and the diaphragm vacuum pump is communicated with the inside of air-tight tank through one-way air suction valve;Each working cavity is provided with one-way air exhaust valve at the bottom, and the one-way air exhaust valve is communicated with the outside atmosphere;Elastic diaphragm is sealingly arranged in the working cavity, and the elastic diaphragm is made of aging-resistant rubber material;The output shaft end of the servo motor is fixedly connected with eccentric shaft, and four groups of push-pull connecting rods are rotatably connected with the eccentric part of the eccentric shaft through bearing, and the other end of each push-pull connecting rod is rotatably connected with the center position of the elastic diaphragm in the corresponding working cavity.

3. The water-soluble enteric resin pharmaceutical multi-dosage form adapting high- efficiency coating kettle according to claim 1, characterized in that, The coating material pipe and hot air pipe are both penetrated in the inside of the metal feeding pipe along the axial direction of the metal feeding pipe, and the coating material pipe and hot air pipe are arranged in parallel;Thermal conductive silicone grease is arranged between the coating material pipe, hot air pipe and the inner wall of the metal feeding pipe.

4. The water-soluble enteric resin pharmaceutical multi-dosage form adapting high- efficiency coating kettle according to claim 3, characterized in that, The coating material pipe, hot air pipe and metal feeding pipe are all made of red copper material, and the inner wall of the coating material pipe is provided with polytetrafluoroethylene anti-sticking coating.

5. The water-soluble enteric resin pharmaceutical multi-dosage form adapting high- efficiency coating kettle according to claim 1, characterized in that, The double-channel electromagnetic valve includes two independent electromagnetic control valve bodies, which are connected with the input ends of the coating material pipe and the hot air pipe respectively, and independently control the feeding flow of the coating material pipe and the air intake of the hot air pipe.

6. The water-soluble enteric resin pharmaceutical multi-dosage form adapting high- efficiency coating kettle according to claim 1, characterized in that, The air heating tank comprises a double-layer heat insulation tank body, the inner layer of the heat insulation tank body is made of stainless steel, and the outer layer is a heat preservation material layer; one end of the heat insulation tank body is provided with an air inlet, and an air inlet filter screen is fixedly installed at the air inlet; the other end of the heat insulation tank body is provided with an air outlet, and the air outlet is in sealed communication with a hot air pipe through a pipeline; and helical electric heating wires are uniformly distributed in the heat insulation tank body along the air flow direction.

7. The water-soluble enteric resin pharmaceutical multi-dosage form adapting high- efficiency coating kettle according to claim 1, characterized in that, The coating material spraying pipes are perpendicular to the axis of the metal feeding pipe and are spaced apart along the axial direction of the metal feeding pipe; four coating material spraying pipes are arranged, and the lengths of the four coating material spraying pipes decrease from top to bottom; the end of each coating material spraying pipe is provided with a fan-shaped nozzle, and the shortest distance from the outlet end of all the nozzles to the inner wall of the rotary coating pot is uniform.

8. The water-soluble enteric resin pharmaceutical multi-dosage form adapting high- efficiency coating kettle according to claim 1, characterized in that, The hot air spraying pipes are perpendicular to the axis of the metal feeding pipe and are spaced apart along the axial direction of the metal feeding pipe; four hot air spraying pipes are arranged, and the lengths of the four hot air spraying pipes decrease from top to bottom; the end of each hot air spraying pipe is provided with a fan-shaped nozzle, and the shortest distance from the outlet end of all the nozzles to the inner wall of the rotary coating pot is uniform.

9. The water-soluble enteric resin pharmaceutical multi-dosage form adapting high- efficiency coating kettle according to claim 1, characterized in that, The coating material spraying pipes and the hot air spraying pipes are symmetrically arranged on the front and back sides of the metal feeding pipe along the axis of the metal feeding pipe, and the spraying directions of the two are opposite; stirring rods are symmetrically arranged on the left and right sides of the metal feeding pipe.

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