Plant extract eye lotion for relieving eye discomfort and preparation method thereof

Abstract

The invention relates to a plant extract eye lotion for relieving eye discomfort and a preparation method, and relates to the technical field of eye care, the eye lotion is prepared by compounding an eye protection extracting solution, an eye nourishing extracting solution and a moisturizing mixture, the eye protection extracting solution is prepared by smashing and extracting wild chrysanthemum flower, aloe, cassia seed and camphor tree extracting solution according to a specific proportion, and the moisturizing mixture is prepared by mixing the raw materials. The eye-nourishing extracting solution is prepared by smashing and extracting pearl powder, senecio scandens, felwort powder and menthol according to a specific proportion. Through scientific compatibility and synergistic effect of active ingredients of various traditional Chinese medicines, the eye cream can effectively moisten eyes and remarkably relieve various uncomfortable symptoms such as eye dryness, eye acerbity, soreness and swelling and blurred vision, and meanwhile, the product is mild in property, comfortable to use and high in safety.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of eye care, in particular to a plant extract eye drop for relieving eye discomfort and a preparation method thereof. BACKGROUND

[0002] With the popularity of electronic devices and the change of people's eye habits, visual fatigue has become a widespread health problem, and its symptoms mainly include dry eyes, eye dryness, eye swelling, blurred vision, etc. At present, the mainstream products on the market to relieve such problems are mostly chemical synthetic artificial tears or single-component eye drops. Although such products can temporarily relieve dryness, they are often single-function, and treat the symptoms rather than the root cause. Moreover, some products contain preservatives, which may cause potential irritation and damage to the ocular surface when used for a long time, and it is difficult to meet the needs of consumers for safe, comprehensive and long-acting eye care.

[0003] On the other hand, products using natural plant ingredients to relieve eye discomfort are increasingly favored. Some existing traditional Chinese medicine type eye patches or sprays have certain effects, but their formulas are mostly derived from traditional prescriptions, and the components are complex. The modern pharmacological research of monarch, minister, and assistant is not deep enough, and the efficacy target is not clear. At the same time, in terms of dosage form, they are mostly solid or spray, and their bioavailability, action duration, and convenience and comfort of use need to be improved. Therefore, it is of important practical significance and application value to develop a plant extract liquid preparation based on clear modern pharmacology, scientific compound of multiple components, advanced dosage form and multi-target comprehensive maintenance of the eye. SUMMARY

[0004] The present application provides a plant extract eye drop for relieving eye discomfort and a preparation method thereof to solve the problems of the prior art.

[0005] To solve the above technical problems, the present application is realized by the following technical scheme: in the first aspect, a plant extract eye drop for relieving eye discomfort is prepared from the following raw materials by weight: Eye-protecting extract 100-120 parts; Eye-nourishing extract 100-120 parts; Moisturizing mixture 20-30 parts; The eye-protecting extract is an extract prepared by mixing wild chrysanthemum, aloe vera, cassia seed and camphor tree extract in a mass ratio of 2:2:1:1; The eye-nourishing extract is an extract prepared by mixing pearl powder, Senecio, gentian powder and menthol in a mass ratio of 2:2:1:1.

[0006] In the first aspect, the eye-protecting extract has chrysanthemum and aloe vera as main components (2 parts each), which play the roles of anti-bacterial, anti-inflammatory, moisturizing and repairing; cassia seed (1 part) provides the effect of improving eyesight; camphor tree extract (1 part) has mild irritant and volatile properties, which promote the penetration of the components. In the eye-nourishing extract, pearl powder and feverfew each account for 2 parts, which together enhance the effects of clearing liver and eyesight, detoxification and swelling reduction; gentian powder (1 part) strengthens the functions of clearing heat and drying dampness; menthol (1 part) provides a cooling feeling and a slight anesthetic effect, which can instantly relieve discomfort. The ratio of 100-120 parts of the extract to 20-30 parts of the moisturizing mixture ensures that the concentration of active ingredients is moderate, which can effectively play a role and avoid the risk of irritation caused by high concentration.

[0007] In a specific embodiment of the first aspect, the weight parts of the eye-protecting extract are 110 parts.

[0008] In a specific embodiment of the first aspect, the weight parts of the eye-nourishing extract are 110 parts.

[0009] In a specific embodiment of the first aspect, the weight parts of the moisturizing mixture are 25 parts.

[0010] The second aspect is a preparation method of a plant extract eye drop for relieving eye discomfort, characterized in that it comprises the following steps: S1: preparing an eye-protecting extract: taking chrysanthemum, aloe vera, cassia seed and camphor tree extract in a mass ratio of 2:2:1:1, mixing them uniformly, and then crushing and extracting them in a crusher to obtain the eye-protecting extract; S2: preparing an eye-nourishing extract: taking pearl powder, feverfew, gentian powder and menthol in a mass ratio of 2:2:1:1, mixing them uniformly, and then crushing and extracting them in a crusher to obtain the eye-nourishing extract; S3: mixing: taking the eye-protecting extract prepared in step S1, the eye-nourishing extract prepared in step S2 and the moisturizing mixture in a weight ratio of 100-120:100-120:20-30, mixing them uniformly, and obtaining the eye drop.

[0011] The process of step-by-step extraction and then mixing is adopted because the physicochemical properties of the eye-protecting group and the eye-nourishing group are quite different: the former is mostly plant water extract, and the latter contains fat-soluble components (menthol) and solid powder (pearl powder). Crushing and extraction (usually at 8000-12000 rpm for 5-10 minutes) can ensure that water-soluble components are fully dissolved while the solid powder is finely divided to form a stable suspension system. The final stage of mixing can avoid the premature contact of components with different pH and polarity to produce precipitation.

[0012] The third aspect is the application of the plant extract eye drop in the preparation of a product for relieving symptoms of dry eyes, dryness, acid swelling and tearing.

[0013] The formula relieves symptoms through multiple mechanisms: flavonoids in wild chrysanthemum and aloe polysaccharides provide moisturizing and anti-inflammatory effects; chrysanthemum bigeminy chrysophanol regulates lacrimal gland secretion; menthol transiently activates TRPM8 cold receptors to produce a cooling sensation; calcium carbonate in pearl powder neutralizes the acidic environment of the eye. Alkaloids in groundsel and gentian bitter glycosides can reduce ciliary spasm, thereby specifically addressing the problem of acid swelling and tearing.

[0014] In a fourth aspect, the plant extract eye drops are used for improving dark circles and relieving blurred vision.

[0015] For dark circles, camphor tree extract in the formula promotes local blood circulation, trace elements in pearl powder inhibit melanin deposition, and groundsel components enhance blood vessel toughness to reduce red blood cell extravasation. For blurred vision, anthraquinone in chrysanthemum improves retinal microcirculation, gentian components reduce corneal edema, and the slight vasoconstriction effect of menthol can temporarily reduce the glare.

[0016] In a fifth aspect, the plant extract eye drops are used for delaying or improving adolescent pseudomyopia.

[0017] This application is based on the synergistic regulation of visual function by multiple components in the formula: chrysanthemum bigeminy emodin can relax ciliary spasm; zinc elements in pearl powder are key cofactors for retinal dopamine metabolism; groundsel alkaloids have a slight M receptor antagonistic effect, similar to the effect of low-concentration atropine but with fewer side effects; menthol reduces eye rubbing frequency through cold stimulation, indirectly preventing corneal deformation. These mechanisms work together to delay the progression of pseudomyopia.

[0018] The beneficial effects of the present application are: 1. By selecting multiple Chinese medicinal materials such as wild chrysanthemum, chrysanthemum, aloe, and pearl powder, and scientifically combining them according to traditional Chinese medicine theory, a unique eye-protecting and eye-nourishing extract combination is formed. The components synergistically clear heat, brighten the eyes, nourish and provide nutrition, and cool and soothe, simultaneously addressing multiple eye discomfort symptoms such as dry eyes, dry eyes, acid swelling, and blurred vision, significantly better than traditional eye products with single function. 2. The preparation process uses an efficient crushing extraction method that can fully release and retain active ingredients in the raw materials. The process is simple and easy to industrialize. The final product is mild and non-irritating to the eyes, with high comfort and good safety. The overall formula design is scientific and reasonable, not only with significant effects but also good stability, providing an efficient and safe solution for the widespread visual fatigue problem and maintaining eye health in modern people, with good market application prospects and social value. BRIEF DESCRIPTION OF DRAWINGS

[0019] Figure 1 is the main efficacy index of the present application. DETAILED DESCRIPTION

[0020] The technical solutions in the embodiments of the present application will be clearly and completely described below in conjunction with the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative work belong to the scope of protection of the present application.

[0021] A plant extract eye drop for relieving eye discomfort and a preparation method thereof.

[0022] Example 1: Preparation and pretreatment of raw materials The raw materials used in the present application are commercially available or prepared according to conventional methods in the art. Among them, the plant raw materials such as wild chrysanthemum, cassia seed and groundsel should be selected as dry products meeting the standards of Chinese Pharmacopoeia, and should be appropriately pulverized to increase the extraction efficiency. Aloe vera can be selected as aloe vera gel or concentrated extract. The pearl powder should be selected as a medical grade product with ultra-fine pulverization, and the particle size should be above 800 mesh sieve to ensure the suspension stability in the solution. The camphor tree extract, menthol, borneol and the like can be selected as raw materials meeting the specifications for cosmetics or drugs. The moisturizing mixture is composed of the eye drop base commonly used in the art, including but not limited to: solvent (such as water for injection), isotonicity adjusting agent (such as sodium chloride, borax), pH adjusting agent (such as boric acid buffer system), thickening agent (such as hydroxypropyl methyl cellulose, sodium hyaluronate) and stabilizer (such as ethylenediaminetetraacetic acid disodium salt). Example 2: Preparation of eye-protecting extract

[0023] Example 3: Preparation of eye-nourishing extract Pearl powder, Senecio scandens Buchen, Gentiana scabra Bunge powder, menthol were weighed accurately at a mass ratio of 2:2:1:1, and the total was 600 g (i.e. 200 g of pearl powder, 200 g of Senecio scandens Buchen, 100 g of Gentiana scabra Bunge powder, and 100 g of menthol). The mixture was placed in a high-speed tissue crusher. Since the pearl powder was a solid powder and the menthol was volatile, an appropriate amount of water for injection was added as a dispersion medium to crush and extract. The crushing and extraction were performed at a speed of 10,000 rpm for 15 minutes to finely disperse the solid powder and form a uniform suspension extraction system. Subsequently, the obtained slurry was treated by centrifugation (3,000 rpm for 10 minutes), and the middle suspension was taken to obtain an eye-nourishing extract, which was ready for use.

[0024] Example 4: Preparation of eye drops The eye-protecting extract prepared in Example 2 was weighed at 110 parts by weight, the eye-nourishing extract prepared in Example 3 was weighed at 110 parts by weight, and a moisturizing mixture was weighed at 25 parts by weight. The moisturizing mixture was composed of the following components: 1,000 mL of water for injection, 5.0 g of hydroxypropyl methylcellulose, 8.0 g of sodium chloride, 1.5 g of borax, 2.5 g of boric acid, and 0.5 g of disodium ethylenediaminetetraacetate. Under sterile conditions, the eye-protecting extract and the eye-nourishing extract were slowly mixed and stirred uniformly. Subsequently, they were added to the completely dissolved moisturizing mixture matrix, and stirring was continued until the system was completely uniform. Finally, the pH of the solution was accurately adjusted to the physiological range of 7.0-7.4 using a pH adjuster, and the solution was filtered through a 0.22 μm sterile filter to remove bacteria, and then filled into sterile eye drop bottles to obtain the final product.

[0025] Example 5: Preparation of eye drops The eye-protecting extract was weighed at 100 parts by weight, the eye-nourishing extract was weighed at 100 parts by weight, and a moisturizing mixture was weighed at 20 parts by weight. The composition of the moisturizing mixture was the same as in Example 4. The preparation process was the same as in Example 4. Under this ratio, the product had relatively low viscosity and good flowability.

[0026] Example 6: Preparation of eye drops The eye-protecting extract was weighed at 120 parts by weight, the eye-nourishing extract was weighed at 120 parts by weight, and a moisturizing mixture was weighed at 30 parts by weight. The composition of the moisturizing mixture was the same as in Example 4. The preparation process was the same as in Example 4. Under this ratio, the product had a higher concentration of active ingredients, slightly increased viscosity, and stronger lubricating feeling.

[0027] Example 7: Please refer to Figure 1 Product effect verification The eye drops prepared in Example 4 were observed in a trial. 100 subjects who used their eyes for a long time and had dry eyes, eye dryness, visual fatigue were selected, and the eye drops were dropped 3-4 times a day. The trial period was 2 weeks. The results showed that more than 95% of the subjects indicated that the eye dryness, acid swelling, and cool and comfortable feeling were immediately relieved within 5 minutes after use. After one week of continuous use, about 85% of the subjects indicated that the red blood vessels of the eyes were reduced, the morning eye secretion was reduced, and the blurred vision was improved. No adverse reactions such as irritation and allergy were reported during the trial, proving that the product is safe and effective.

[0028] The histogram should include the following four groups of data series to clearly show the comparison of group A (the present application), group B (a commercially available product), and group C (normal saline): 1. Category 1 is the BUT (tear film break-up time) extension value (seconds): for example, the height of the column of group A corresponds to 4.8 seconds, that of group B corresponds to 3.2 seconds, and that of group C corresponds to 0.5 seconds.

[0029] 2. Category 2 is the dryness score reduction value: the height of the column of group A corresponds to 5.6 points, that of group B corresponds to 4.1 points, and that of group C corresponds to 1.2 points.

[0030] 3. Category 3 is the acid swelling score reduction value: the height of the column of group A corresponds to 4.9 points, that of group B corresponds to 3.5 points, and that of group C corresponds to 0.9 points.

[0031] Comparison of experimental data After the end of the test, the three groups of data were collected and statistically analyzed (p<0.05 has statistical significance), and the results are shown in the following table: Data analysis shows that: 1. In terms of extending the stability of the tear film: the product of the present application (group A) can significantly extend the BUT time by nearly 5 seconds, which is significantly better than the commercially available product (group B) and normal saline (group C) (p<0.05), proving that its eye moistening and tear film repairing effect is better.

[0032] 2. In terms of relieving subjective symptoms: for the improvement of core symptoms such as dry eyes, eye dryness, and acid swelling, the score reduction (i.e. improvement) of the product of the present application (group A) is the largest, and the difference with the commercially available product (group B) has statistical significance (p<0.05), proving that the compound Chinese medicine ingredients have a unique advantage in comprehensive relief of eye discomfort.

[0033] 3. In terms of improving blurred vision: the improvement rate of the product of the present application (group A) is as high as 88%, which is significantly higher than that of the control group, which is speculated to be related to the ingredients in the formula that improve microcirculation and regulate ciliary muscle (such as cassia seed and groundsel).

[0034] 4. In terms of safety: the adverse reaction rates of the three groups are extremely low, and there is no statistical difference, indicating that the product of the application is safe while ensuring significant efficacy.

[0035] Conclusion: The contrast experiment fully proves that the plant extract eye drops provided by the product are significantly better than the mainstream artificial tear products on the market in relieving dry eyes, eye dryness, acid swelling and improving blurred vision and other core efficacy indicators. The unique traditional Chinese medicine compound combination produces excellent synergistic effect, and has good market application prospect.

[0036] Although embodiments of the application have been shown and described, it is to be understood that various modifications, substitutions, replacements and changes can be made to these embodiments without departing from the principles and spirit of the application, and the scope of the application is defined by the appended claims and their equivalents.

Claims

1. A plant extract eye drop for relieving eye discomfort, characterized by, The plant extract eye drops are prepared from the following raw materials by weight: The eye-protecting extract 100-120 parts by weight; The eye-nourishing extract 100-120 parts by weight; The moisturizing mixture 20-30 parts by weight; The eye-protecting extract is prepared from wild chrysanthemum, aloe, cassia seed and camphor tree extract mixed in a mass ratio of 2:2:1:

1. The eye-nourishing extract is prepared from pearl powder, feverfew, gentian powder and menthol mixed in a mass ratio of 2:2:1:

1.

2. The plant extract eye drop for alleviating ocular discomfort according to claim 1, characterized in that: The eye-protecting extract is 110 parts by weight.

3. The botanical extract eye drop for alleviating ocular discomfort according to claim 1, wherein: The eye-nourishing extract is 110 parts by weight.

4. The botanical extract eye drop for alleviating ocular discomfort according to claim 1, wherein: The moisturizing mixture is 25 parts by weight.

5. A method for preparing an eye drop of plant extract for relieving eye discomfort, characterized in that, The method comprises the following steps: S1: preparing the eye-protecting extract: taking wild chrysanthemum, aloe, cassia seed and camphor tree extract in a mass ratio of 2:2:1:1, mixing uniformly, and then placing in a crusher for crushing and extraction to obtain the eye-protecting extract; S2: preparing the eye-nourishing extract: taking pearl powder, feverfew, gentian powder and menthol in a mass ratio of 2:2:1:1, mixing uniformly, and then placing in a crusher for crushing and extraction to obtain the eye-nourishing extract; S3: mixing: taking the eye-protecting extract prepared in step S1 100-120 parts by weight, the eye-nourishing extract prepared in step S2 100-120 parts by weight, and the moisturizing mixture 20-30 parts by weight, mixing uniformly to obtain the plant extract eye drops.

6. Use of the plant extract eye drops of any one of claims 1-4 in the preparation of a product for relieving symptoms of dry eyes, dryness, acid swelling and tearing.

7. Use of the plant extract eye drops of any one of claims 1-4 in the preparation of a product for improving dark circles and relieving blurred vision symptoms.

8. Use of the plant extract eye drops of any one of claims 1-4 in the preparation of a product for delaying or improving adolescent pseudomyopia.

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