Biomarker for screening intestinal flora transplantation donors and application thereof

By detecting the abundance of gut microbiota and its metabolites, a standard for qualified donors was established, which solved the problem of inaccurate donor screening in existing technologies for gut microbiota transplantation. This enabled efficient and accurate donor screening, ensuring the effectiveness and safety of gut microbiota transplantation.

CN121023052APending Publication Date: 2025-11-28SUZHOU SHANBAI BIOTECHNOLOGY CO LTD
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Patent Information

Application Number
CN202511147020.6
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-08-15
Publication Date
2025-11-28

AI Technical Summary

Technical Problem

The lack of a precise method for evaluating gut microbiota transplantation donors in existing technologies leads to inefficient and inaccurate donor selection, making it difficult to ensure the efficiency and safety of gut microbiota transplantation.

Method used

Intestinal flora and their metabolites were used as biomarkers, including Firmicutes, Bacteroides, Bacteroides and Prevotella, as well as metabolites such as short-chain fatty acids, indole, 5-hydroxytryptamine and lipopolysaccharide. The abundance of these biomarkers was detected by 16S rRNA gene sequencing and mass spectrometry to establish the criteria for qualified donors.

Benefits of technology

This approach enables efficient and precise screening of gut microbiota transplantation donors, providing new screening methods and approaches, and ensuring the effectiveness and safety of gut microbiota transplantation.

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Abstract

The invention relates to a biomarker for screening intestinal flora transplantation donors and application of the biomarker. The biomarker comprises intestinal flora and metabolites thereof, the intestinal flora comprises phylum firmicalis, bacteroides and the like, and the metabolites comprise short-chain fatty acid, tryptophan, indole, 5-hydroxytryptamine, lipopolysaccharide and the like. According to the method, the intestinal flora of different crowds is deeply analyzed, the relationship between each related index of the intestinal flora and the intestinal flora transplantation effect is studied, sufficient clinical verification is carried out, a biomarker for screening the intestinal flora transplantation donor is excavated, and a standard for judging whether the intestinal flora transplantation donor is qualified or not is established; and a new method and a new idea are provided for efficiently and accurately screening intestinal flora transplantation donors.
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