Insecticidal composition containing amide insecticide and application thereof

Abstract

The invention belongs to the technical field of pesticide disinfestation, and discloses an insecticidal composition containing an amide insecticide and application thereof.The active ingredient of the insecticidal composition comprises an active ingredient A and an active ingredient B. The active ingredient A is a compound shown in the formula I, and the active ingredient B is the amide insecticide. The amide pesticide is any one of tolfenpyrad, cyhalodiamide, tetrachlorantraniliprole, polyflubendiamide, thiotraniliprole and thiodicyclaniliprole, and the compound pesticide is a compound of the following components in parts by weight; the mass ratio of the active component A to the active component B is (1: 40)-(40: 1). According to the insecticidal composition, the insecticidal effect is greatly improved, the utilization rate of the insecticide is increased, the development of insecticide resistance of pests is slowed down, and the service life of the insecticide is prolonged.

Description

[0001] This invention application is a divisional application of application number 202411238203.4, filed on September 5, 2024, entitled "An insecticidal composition containing an amide insecticide and its application". Technical Field

[0002] This invention belongs to the field of pesticide insecticide technology, and discloses an insecticidal composition containing amide insecticides and its application. Background Technology

[0003] Amide insecticides have diverse and novel structures, rich and unique mechanisms of action, and excellent and broad-spectrum insecticidal effects.

[0004] Tolfenpyrad, common name: 4-chloro-5-ethyl-2-methyl-N-[[4-(4-methylphenoxy)phenyl]methyl]pyrazole-3-carboxamide, CAS Registry Number: 129558-76-5, chemical name: 4-chloro-5-ethyl-2-methyl-N-[[4-(4-methylphenoxy)phenyl]methyl]pyrazole-3-carboxamide, its structural formula is shown below:

[0005]

[0006] Cyhalodiamide, common name: cyhalodiamide, CAS Registry Number: 1262605-53-7, chemical name: 3-chloro-2-N-(2-cyanopropyl-2-yl)-1-N-[4-(1,1,1,2,3,3,3-heptafluoropropyl-2-yl)-2-methylphenyl]benzene-1,2-dicarboxamide, its structural formula is shown below:

[0007]

[0008] Tetrachlorantraniliprole, common name: tetrachlorantraniliprole, CAS Registry Number: 1104384-14-6, chemical name: 3-bromo-N-(2,4-dichloro-6-(methylcarbamoyl)phenyl)-1-(3,5-dichloropyridin-2-yl)-1H-pyrazole-5-carboxamide, its structural formula is shown below:

[0009]

[0010] Piperflanilide, CAS Registry Number: 2615135-05-0, Chemical Name: N-(3-{[2-bromo-6-(difluoromethoxy)-4-(1,1,1,2,3,3,3-heptafluoropropyl-2-yl)phenyl]carbamoyl}-2-fluorophenyl)-2,2-difluoro-N-methyl-2H-1,3-benzodioxapentane-5-carboxamide, its structural formula is shown below:

[0011]

[0012] Thionamide, international common name: tiorantraniliprole, CAS Registry Number: 1442448-92-1, chemical name: 5-bromo-2-(3-chloropyridin-2-yl)-N-[2,4-dichloro-6-(propyl-2-ylaminomethylthioyl)phenyl]pyrazole-3-carboxamide, its structural formula is shown below:

[0013]

[0014] Pioxaniliprole, international common name: pioxaniliprole, CAS Registry Number: 2368920-61-8, chemical name: N-[2-(tert-butylcarbamoyl)-4-chloro-6-methylphenyl]-1-(3-chloropyridin-2-yl)-3-[(1,1-dioxane-1λ] 6 [-Thiohexacyclic butyl-3-yl)oxy]-1H-pyrazole-5-carboxamide, the structural formula of which is shown below:

[0015]

[0016] Excessive pesticide use can lead to pesticide resistance in pests, rendering pesticide applications ineffective. Amide insecticides, in particular, are a new type of highly effective insecticide used in my country in recent years to control major pests such as the rice stem borer, rice leaf roller, and diamondback moth on crops like rice and vegetables. They are characterized by high efficiency, low toxicity, and low dosage, and have been well-received since entering the Chinese market. However, it is undeniable that due to years of continuous and extensive use, many pests in Jiangsu, Jiangxi, Hunan, Guangdong, and Yunnan provinces have developed resistance to amide insecticides. Summary of the Invention

[0017] To address the aforementioned problems in the prior art, this invention rationally combines the compound shown in Formula I with amide insecticides tolfenpyrad, cyhalodiamide, tetrachlorantraniliprole, piperflanilide, tiorantraniliprole, and pioxaniliprole to provide an insecticidal composition containing amide insecticides. This insecticidal composition exhibits excellent control effects against plant pests, demonstrates a significant synergistic effect, reduces pesticide dosage, and significantly slows down the development of pest resistance.

[0018] To achieve the above objectives, the present invention adopts the following technical solution: an insecticidal composition containing an amide-based insecticide, wherein the active ingredients of the insecticidal composition include active ingredient A and active ingredient B, and active ingredient A is a compound represented by formula I:

[0019] The active ingredient B is an amide insecticide, which is any one of tolfenpyrad, cyhalodiamide, tetrachlorantraniliprole, piperflanilide, tiorantraniliprole, and pioxaniliprole; the mass ratio of active ingredient A to active ingredient B is 1:40 to 40:1, or any value within the above range.

[0020] Furthermore, the active ingredient B is tolfenpyrad, and the mass ratio of active ingredient A to active ingredient B is 1:27 to 32:1, or any value within the above range.

[0021] The active ingredient B is cyhalodiamide, and the mass ratio of active ingredient A to active ingredient B is 1:23 to 28:1, or any value within the above range.

[0022] The active ingredient B is tetrachlorantraniliprole, and the mass ratio of active ingredient A to active ingredient B is 1:35 to 32:1, or any value within the above range.

[0023] The active ingredient B is piperflanilide, and the mass ratio of active ingredient A to active ingredient B is 1:20 to 24:1, or any value within the above range.

[0024] The active ingredient B is thioantraniliprole, and the mass ratio of active ingredient A to active ingredient B is 1:22 to 32:1, or any value within the above range.

[0025] The active ingredient B is pioxaniliprole, and the mass ratio of active ingredient A to active ingredient B is 1:25 to 32:1, or any value within the above range.

[0026] Furthermore, the active ingredient B is tolfenpyrad, and the mass ratio of active ingredient A to active ingredient B is 1:18 to 16:1, or any value within the above range.

[0027] The active ingredient B is cyhalodiamide, and the mass ratio of active ingredient A to active ingredient B is 1:15 to 20:1, or any value within the above range.

[0028] The active ingredient B is tetrachlorantraniliprole, and the mass ratio of active ingredient A to active ingredient B is 1:28 to 16:1, or any value within the above range.

[0029] The active ingredient B is piperflanilide, and the mass ratio of active ingredient A to active ingredient B is 1:12 to 24:1, or any value within the above range.

[0030] The active ingredient B is thioantraniliprole, and the mass ratio of active ingredient A to active ingredient B is 1:18 to 25:1, or any value within the above range.

[0031] The active ingredient B is pioxaniliprole, and the mass ratio of active ingredient A to active ingredient B is 1:15 to 32:1, or any value within the above range.

[0032] Furthermore, the active ingredient B is tolfenpyrad, and the mass ratio of active ingredient A to active ingredient B is 1:9 to 8:1, or any value within the above range.

[0033] The active ingredient B is cyhalodiamide, and the mass ratio of active ingredient A to active ingredient B is 1:15 to 10:1, or any value within the above range.

[0034] The active ingredient B is tetrachlorantraniliprole, and the mass ratio of active ingredient A to active ingredient B is 1:16 to 8:1, or any value within the above range.

[0035] The active ingredient B is piperflanilide, and the mass ratio of active ingredient A to active ingredient B is 1:10 to 16:1, or any value within the above range.

[0036] The active ingredient B is thioantraniliprole, and the mass ratio of active ingredient A to active ingredient B is 1:18 to 14:1, or any value within the above range.

[0037] The active ingredient B is pioxaniliprole, and the mass ratio of active ingredient A to active ingredient B is 1:15 to 24:1, or any value within the above range.

[0038] Furthermore, in addition to the active ingredient, the insecticidal composition also includes other pesticide-acceptable adjuvants selected from one or more of dispersants, wetting agents, emulsifiers, stabilizers, antifreeze agents, defoamers, preservatives, thickeners, solvents, organic acids, and dispersion media.

[0039] Furthermore, the formulation of the insecticidal composition is prepared in one or more of the following forms: emulsifiable concentrate, microemulsion, soluble liquid, suspension concentrate, aqueous solution, water emulsion, ultra-low volume liquid, dispersible oil suspension, water-dispersible granules, or wettable powder.

[0040] The present invention also discloses the application of the insecticidal composition described above in the control of plant pests.

[0041] Furthermore, the insecticidal composition of the present invention has a significant synergistic effect on the following lepidopteran pests: diamondback moth (Plutella xylostella), small diamondback moth (Plutella xylostella), grape leafroller (Polychrosis viteana), citrus leafroller (Prays endocarpa), olive leafroller (Prays oleae), noctuid moth (Pseudaletia spp.), armyworm (Pseudaletia unipunctata), soybean looper (Pseudoplusia includes), inchworm (Rachiplusia nu), rice stem borer (Scirpophaga incertulas), stem borer (Sesamia spp.), and pink rice stem borer (Sesamia inferens). The following species are listed: borer, Sesamia nonagrioides, Setora nitens, Sitotroga cerealella (Angoumois grain moth), Sparganothispilleriana, Spodoptera spp. (noctuid moth), Spodoptera exigua (beet armyworm), Spodoptera fugiperda (fallarmyworm), Adoxophyes spp., Adoxophyes orana, and Agrotis spp.(Root cutter), small groundworm (Agrotis ipsilon) (black cutworm), cotton leaf looper (Alabama argillacea), Amorbia cuneana, Amyelosis transitella (navel orange worm), peach twig borer (Anarsia lineatella), yellow hemp looper (Anomis sabulifera), bean looper (Anticaria gemma talis), fruit tree leaf roller (Archi ps argyrospila), rose leaf roller (Archips rosana), tortricid moths (Argyrotaenia spp.), citrus leaf roller (Argyrotaenia citrana), Autographa gamma, Bonagota *Cranaodes*, *Borbo cinnara*, *Caloptilias* spp. (leaf miners), *Capua reticulana*, *Carposina niponensis* (peach fruit moth), *Chilo* spp., *Chlumetia transversa* (mango shoot borer), *Choristoneura rosaceana* (obliquebanded leafroller), *Chrysodeixis* spp., *Cnaphalocerus medinalis* (grass leafroller), *Colias* spp., *Conpomorpha cramerella*, *Cossus cossus*, *Crambus* spp.(Sod webworms), Plum fruit moth (Cydiafunebrana), Oriental fruit moth (Cydia molesta), Pea moth (Cydia nignicana), Apple leafroller (Cydia pomonella), Darna diducta, Stem borers (Diaphaniaspp.), Stalk borers (Diatraeas spp.), Sugarcane borer (Diatraeas accharalis), Southwest corn borer (Diatraea graniosella), Cotton bollworm (Earias spp.), Egyptian bollworm (Earias) *Egyptian bollworm* (*E. insulata*), *Rough northern bollworm* (*Earias vitella*), *Ecdytopopha aurantianum*, *Lesser cornstalk borer* (*Elasmopalpus lignosellus*), *Flour moths* (*Ephestia* spp.), *Almond moth* (*Ephestia cautella*), *Tobacco moth* (*Ephestia elutella*), *Mediterranean flour moth* (*Ephestia kuehniella*), *Epimeces* spp., *Epinotia aporema*, *Banana skipper* (*Erionota thrax*), *Eupoecilia* ambiguella), Euxoaauxiliaris (army cutworm), species of the genus Feltia (Feltia spp.), species of the genus Gortyna (Gortyna spp.).(Stemborers), Oriental fruit moth (Grapholita molesta), Hedylepta indicate, bean leaf webber, Helicoverpa sp. (noctus), cotton bollworm (Helicover paarmigera), cereal noctus (Helicoverpa zea), noctus (Heliothis spp.), tobacco bud noctus (Heliothisvirescens), tobacco budworm (Hellula undalis), cabbage webworm (Indarbela spp.), root borers, tomato codling moth (Keiferia lycopersicella), tomato pinworm, eggplant fruit borer (Leucinodesorbonalis) The following species are listed: borer, Leucoptera malifoliella, Lithocollectis spp., Lobesia botrana (grape fruitmoth), Loxagrotis spp. (noctus), Loxagrotis albicosta (western bean cutworm), Lymantria dispar (gypsy moth), Lyonetia clerkella (apple leaf miner), Mahasena corbetti (oil palm bagworm), and Malacosoma spp.(tent caterpillars), cabbage armyworm (Mamestra brassicae), bean pod borer (Maruca testulalis), bagworm (Metisa plana), true armyworm (Mythimna unipuncta), small tomato borer (Neoleucinodes elegantalis), winter moth (Operophthera brumata), European corn borer (Ostrinia nubilalis), Pandemiscerasana, common currant tortrix, brown apple tortrix (Pandemis heparana), African swallowtail butterfly (Papilio demodocus), pink bollworm (Pectinophoragossypiella), species of Peridroma (Peridroma) spp. (root cutter), Peridroma saucia (variegated cutworm), Perileucoptera coffeella (white coffee leafminer), Phthorimaea operculella (potato tuber moth), Phyllocnisitiscitrella (citrus leafminer), Phyllonorycter spp. (leaf miner), Pieris rapae (imported cabbage worm), Plathapypena scabra, Plodiainterpunctella (Indian meal moth), Spodoptera oridania (southern armyworm), Synanthedon spp.(root borers), Thecla basilides, Thermisia gemmatalis, clothes moth (Tineola bisselliella) (webbing clothes moth), cabbage caterpillar (Trichoplusia ni) (carrot caterpillar), tomato leafminer (Tutaabsoluta), nest moth (Yponomeuta spp.), coffee leopard borer (Zeuzera coffeae) (red branch borer), and pear leopard borer (Zeuzera pyrina) (leopard moth).

[0042] In particular, the insecticidal composition of the present invention has a significant synergistic effect on lepidopteran pests such as cotton bollworm, beet armyworm, rice stem borer, diamondback moth, and cabbage caterpillar, and has excellent control effect.

[0043] Furthermore, the insecticidal composition is applied to pests and the medium in which they occur.

[0044] To achieve the desired insecticidal effect, the dosage of the insecticidal composition varies depending on various factors, such as the crop to be protected, the type of pest, the degree of infection, climatic conditions, application location, application method, and formulation used.

[0045] The beneficial effects of this invention are as follows:

[0046] 1) The present invention rationally combines insecticidal compositions with different mechanisms of action, which greatly improves the insecticidal effect of amide insecticides, has a significant synergistic effect, improves the utilization rate of the agent, and reduces environmental pollution;

[0047] 2) The insecticidal composition of the present invention can significantly delay the development of insecticide resistance in pests, reduce production costs, and extend the service life of a single agent. Detailed Implementation

[0048] To make the technical solution, objectives and advantages of the present invention clearer, the present invention is described with reference to the following specific embodiments. However, the present invention can be implemented in various forms and should not be limited to the embodiments described herein.

[0049] Formulation preparation example:

[0050] Preparation Example 1: 20% Formula I compound pyraclostrobin suspension (1:9)

[0051] Formula: 2% Formula I compound, 18% acetamiprid, 2% sodium dodecyl sulfate, 3% sorbitan oleate polyoxyethylene ether, 4% tristyrene phenol ethoxylate phosphate, 0.25% xanthan gum, 1% magnesium aluminum silicate, 5% glycerol, 0.01% potassium benzoate, 0.5% silicone oil, deionized water to make up the balance;

[0052] Preparation method: According to the formula ratio, the active ingredients, surfactants and other functional additives are placed in the reaction vessel in sequence, water is added and mixed evenly, and then subjected to high-speed shearing, wet sand milling and finally homogenization filtration to obtain the suspension product.

[0053] Preparation Example 2: 25% Formula I compound pyraclostrobin water-dispersible granules (2:3)

[0054] Formula: 10% Formula I compound, 15% acetamiprid, 6% lignin sulfonate, 6% sodium alkyl polyoxyethylene ether sulfonate, 3% sodium dodecyl sulfate, 5% silica, 25% starch, kaolin to make up the balance;

[0055] Preparation method: According to the formulation of the example, the active ingredient is added to the carrier, and surfactants and other functional additives are added thereto. After mixing, the mixture is pulverized by air jet and 10-25% water is added. Then, the mixture is kneaded, granulated, dried and sieved to obtain a water-dispersible granule product; or the pulverized powder is sprayed with water, granulated and dried in a fluidized bed granulator, and then sieved to obtain the product.

[0056] Preparation Example 3: 18% Compound I·Acetamide EC (7:2)

[0057] Formula: 14% Formula I compound, 4% acetamiprid, 2% antioxidant BHT, 15% DMF, 12% castor oil polyoxyethylene ether, 2% calcium dodecylbenzenesulfonate, 20% propylene carbonate, xylene to make up the balance;

[0058] Preparation method: According to the formula ratio, the measured active ingredients, solvents and co-solvents are added to the mixing tank and stirred to dissolve them. Then, the emulsifier is added, and the remaining solvent is used to make up the balance. The mixture is stirred evenly in the mixing tank and filtered to obtain the emulsifiable oil required by the present invention.

[0059] Preparation Example 4: 4.5% Formula I compound pyraclostrobin microemulsion (8:1)

[0060] Formula: 4% Formula I compound, 0.5% acetamiprid, 2% antioxidant BHT, 15% xylene, 20% cyclohexanone, 12% tristyrene-phenol polyoxyethylene ether polyoxypropylene ether, 6% EO-PO block copolymer, 2% fatty alcohol polyoxyethylene ether sulfate, 5% propylene glycol, 0.15% silicone defoamer, deionized water to make up the balance;

[0061] Preparation method: According to the formula ratio, the active ingredients are completely dissolved in the solvent, and an emulsifier is added to form an oil phase. Dispersant, deionized water and other ingredients are added and stirred evenly to form an aqueous phase. The oil phase is added to the aqueous phase and stirred evenly. The particles are sheared at high speed until the particle size is qualified. After adding the defoamer, the mixture is stirred evenly to obtain the microemulsion product.

[0062] Preparation Example 5: 16% Formula I compound·chlorfenapyr dichlorvos dispersible oil suspension (1:15)

[0063] Formula: 1% Formula I compound, 15% chlorfenapyr, 2% naphthalene sulfonate formaldehyde condensate, 3% Gelbert alcohol polyoxyethylene ether, 10% triphenylethylphenol polyoxyethylene ether, 3% ethylene glycol oxyethylene polyoxypropylene ether, 2% calcium dodecylbenzenesulfonate, 1% silica, 1% organobentonite, methyl oleate to make up the balance;

[0064] Preparation method: According to the formula ratio, the active ingredients, surfactants and other functional additives are placed in the reaction vessel in sequence, oil is added and mixed evenly, and then subjected to high-speed shearing, wet sand milling and finally homogenization filtration to obtain the dispersible oil suspension product.

[0065] Preparation Example 6: 24% Formula I compound·chlorfenapyr suspension (2:1)

[0066] Formula: 16% Formula I compound, 8% chlorfenapyr, 1% alkylaryl polyoxyethylene ether polyoxypropylene ether, 5% tristyrene phenol ethoxylate phosphate, 1% sodium lignosulfonate, 3% sodium octylphenol polyoxyethylene ether sulfonate, 0.25% xanthan gum, 5% ethylene glycol, 0.1% sodium sorbate, 0.5% silicone oil, deionized water to make up the balance;

[0067] Preparation method: Same as in preparation example 1.

[0068] Preparation Example 7: 24% Formula I compound·chlorfenapyr water-dispersible granules (5:1)

[0069] Formula: 20% Compound I, 4% Chlorfenapyr, 8% Succinate Sulfonate, 2% BX Powder, 5% Sodium Polycarboxylate, 3% Sugar, Kaolin to make up the balance;

[0070] Preparation method: Same as in preparation example 2.

[0071] Preparation Example 8: 33% Formula I compound·chlorfenapyr wettable powder (10:1)

[0072] Formula: 30% Formula I compound, 3% chlorfenapyr, 3% fatty alcohol ethylene oxide-propylene oxide copolymer, 6% sodium lignosulfonate, 10% dispersant NNO, 2% separating powder BX, 6% silica, kaolin to make up the balance;

[0073] Preparation method: The active ingredients, dispersant, wetting agent and filler are mixed according to the formula ratio, stirred evenly in a stirring tank, and then pulverized and mixed evenly multiple times by an air jet mill to prepare the wettable powder of the composition of the present invention.

[0074] Preparation Example 9: 27% Formula I compound·tetrachlorfenapyr suspension (1:1)

[0075] Formula: 13.5% Formula I compound, 13.5% tetrachlorantraniliprole, 2% isotridecyl alcohol polyoxyethylene ether, 2% ethylene glycol oxyethylene polyoxypropylene ether, 3% styrene-phenol polyoxyethylene ether sulfate, 1% sodium polycarboxylate, 1.5% magnesium aluminum silicate, 0.1% carboxyethyl cellulose, 1% Kathon, 5% ethylene glycol, 0.25% silicone oil, deionized water to make up the balance;

[0076] Preparation method: Same as in preparation example 1.

[0077] Preparation Example 10: 35% Formula I compound·tetrachlorfenapyr water-dispersible granules (1:4)

[0078] Formula: 7% Formula I compound, 28% tetrachlorantraniliprole, 3% sodium polycarboxylate, 4% naphthalene sulfonate formaldehyde condensate, 12% calcium lignosulfonate, 2% fatty alcohol polyoxyethylene ether sulfate, 10% ammonium sulfate, and starch to make up the balance.

[0079] Preparation method: Same as in preparation example 2.

[0080] Preparation Example 11: 18% Formula I compound·tetrachlorfenapyr dispersible oil suspension (8:1)

[0081] Formula: 16% Formula I compound, 2% tetrachlorantraniliprole, 5% sorbitan oleate polyoxyethylene ether, 8% castor oil polyoxyethylene ether, 2% calcium dodecylbenzenesulfonate, 2% sodium polycarboxylate, 1% organic bentonite, soybean oil to make up the balance;

[0082] Preparation method: Same as in preparation example 3.

[0083] Preparation Example 12: 21% Formula I compound·polyfluoride suspension (1:6)

[0084] Formula: 3% Formula I compound, 18% polyfluorinated biamide, 2% ethylene glycol oxyethylene polyoxypropylene ether, 1% naphthalene sulfonate formaldehyde condensate, 3% tristyrene phenol ethoxylate phosphate, 3% castor oil polyoxyethylene ether, 0.2% xanthan gum, 1% magnesium aluminum silicate, 5% ethylene glycol, 0.2% sodium benzoate, 0.5% silicone oil, deionized water to make up the balance;

[0085] Preparation method: Same as in preparation example 1.

[0086] Preparation Example 13: 20% Formula I compound·polyfluoride diamide water-dispersible granules (3:2)

[0087] Formula: 12% Formula I compound, 8% polyfluorinated biamide, 3% wetting agent EFW, 7% naphthalene sulfonate formaldehyde condensate, 5% sodium alkyl polyoxyethylene ether sulfonate, 5% silica, 20% starch, kaolin to make up the balance;

[0088] Preparation method: Same as in preparation example 2.

[0089] Preparation Example 14: 30% Formula I compound·polyfluoride wettable powder (5:1)

[0090] Formula: 25% Formula I compound, 5% polyfluoride diamide, 2% sodium dodecyl sulfate, 5% styrene-phenol polyoxyethylene ether sulfate, 5% tea saponin, 2% sodium alginate, 10% light calcium carbonate, kaolin to make up the balance;

[0091] Preparation method: Same as in preparation example 8.

[0092] Preparation Example 15: 22% Formula I compound·thiocarbamate suspension (1:10)

[0093] Formula: 2% Formula I compound, 20% thiocyanate, 5% tristyrylphenol polyoxyethylene ether polyoxypropylene ether, 5% arylphenol polyoxyethylene ether phosphate, 2% sodium polycarboxylate, 0.25% xanthan gum, 5% propylene glycol, 0.1% sodium benzoate, 0.5% silicone oil, deionized water to make up the balance;

[0094] Preparation method: Same as in preparation example 1.

[0095] Preparation Example 16: 35% Formula I compound·thiocarbamate water-dispersible granules (5:2)

[0096] Formula: 25% Formula I compound, 10% thiocyanate, 2% sodium dodecyl sulfate, 10% sodium lignosulfonate, 5% naphthalene sulfonate formaldehyde condensate, 10% ammonium sulfate, kaolin to make up the balance;

[0097] Preparation method: Same as in preparation example 2.

[0098] Preparation Example 17: 8% Formula I compound·thiofenazate emulsifiable concentrate (7:1)

[0099] Formula: 7% Formula I compound, 1% thiocyanate, 15% propylene glycol methyl ether, 10% tristyrene-phenylphenol polyoxyethylene ether, 2% calcium dodecylbenzenesulfonate, 15% DMF, 18% cyclohexanone, methyl oleate to make up the balance;

[0100] Preparation method: According to the formula ratio, add the active ingredient, solvent and co-solvent into the mixing tank and stir to dissolve them. Then add the emulsifier, and use the remaining solvent to make up the balance. Stir evenly in the mixing tank, and filter to obtain the emulsifiable oil required by the present invention.

[0101] Preparation Example 18: 22% Formula I compound·thioclase suspension (5:6)

[0102] Formula: 10% Formula I compound, 12% thiocarbamate, 6% glycerol fatty acid ester polyoxyethylene ether, 5% tristyrene phenol ethoxylate phosphate, 2% naphthalene sulfonate, 0.25% xanthan gum, 5% glycerol, 0.15% sodium sorbate, 0.5% silicone oil, deionized water to make up the balance;

[0103] Preparation method: Same as in preparation example 1.

[0104] Preparation Example 19: 30% Formula I compound thiocyclam water-dispersible granules (1:4)

[0105] Formula: 6% Compound I, 24% Thionyl sulfonamide, 2% Sodium dodecyl sulfate, 8% Naphthalene sulfonate formaldehyde condensate, 6% Sodium polycarboxylate, 8% Ammonium sulfate, kaolin to make up the balance;

[0106] Preparation method: Same as in preparation example 2.

[0107] Preparation Example 20: 8% Formula I compound·thioclase emulsifiable concentrate (7:1)

[0108] The formula contains 7% Formula I compound, 1% thiocyanate, 15% propylene glycol methyl ether, 10% oleic acid polyoxyethylene ether, 2% calcium dodecylbenzenesulfonate, 12% DMF, 20% cyclohexanone, and methyl oleate to make up the balance.

[0109] Preparation method: According to the formula ratio, add the active ingredient, solvent and co-solvent into the mixing tank and stir to dissolve them. Then add the emulsifier, and use the remaining solvent to make up the balance. Stir evenly in the mixing tank, and filter to obtain the emulsifiable oil required by the present invention.

[0110] Indoor bioactivity testing:

[0111] Example 1: Indoor bioactivity test of the compound composition against rice stem borer

[0112] Test basis: The test referenced NY / T 1154.10-2008 "Guidelines for Indoor Bioassay Tests of Pesticides - Insecticides Part 10: Artificial Feed Mixture Method".

[0113] Biological test material: Rice stem borer, selected from third-instar larvae that were continuously reared indoors and had the same physiological state.

[0114] Test agents: azoxystrobin, chlorfenapyr, tetrachlorfenapyr, polyflufenican, thiofenoxam, thiocyclophosphamide, and technical grade compound of formula I.

[0115] Pharmaceutical preparation: Dissolve the above raw materials in a suitable organic solvent to prepare a stock solution, and then prepare five series of mass concentrations using Tween-80 aqueous solution in a proportional manner.

[0116] Experimental method: Mix an appropriate amount of diluted drug solution evenly into the prepared artificial feed, pour it into a 12-well plate while it is still hot and let it cool. Then, inoculate one test insect into each well. Each treatment is repeated 4 times, with 20 test insects per repeat. A treatment without the drug (containing organic solvent) is set up as a blank control.

[0117] Feeding and observation: The treated test insects were fed and observed under conditions of (25±1)℃, relative humidity of 60%~80%, and photoperiod of L:D=(16:8)h. After 48h of treatment, the mortality of the test insects was checked, and the total number of insects and the number of dead insects were recorded.

[0118] Calculation method:

[0119] Calculate the mortality rate for each treatment based on the survey data.

[0120] Calculate using the following formula:

[0121]

[0122] In the formula:

[0123] P – Mortality rate, expressed as a percentage (%);

[0124] K represents the number of dead insects, in heads;

[0125] N represents the total number of insects treated, in units of heads.

[0126]

[0127] In the formula:

[0128] P1 – Corrected mortality rate, in percentage (%);

[0129] P t —The mortality rate is expressed as a percentage (%).

[0130] P0 – Mortality rate in the blank control group, expressed as a percentage (%).

[0131] If the control mortality rate is <5%, no correction is needed; if the control mortality rate is between 5% and 20%, correction should be performed according to the corrected mortality rate formula; if the control mortality rate is >20%, the trial needs to be repeated.

[0132] The DPS statistical analysis system was used to analyze the data and obtain the virulence regression equation, correlation coefficient, and LC. 50 The value is used to evaluate the activity of the test reagent on the biological sample.

[0133] The co-toxicity coefficient (CTC value) of the mixture is calculated using the following formula:

[0134]

[0135] In the formula:

[0136] ATI – Actual Measured Toxicity Index of Mixtures;

[0137] S – LC50 of standard insecticides 50 The unit is milligrams per liter (mg / L);

[0138] M – LC of the mixture 50 The unit is milligrams per liter (mg / L).

[0139] TTI = TI A ×P A +TI B ×P B

[0140] In the formula:

[0141] TTI – Theoretical Toxicity Index of Mixtures;

[0142] TI A —A. Toxicity index of drug A;

[0143] P A —Percentage content of drug A in the mixture, expressed as percentage (%);

[0144] TI B —Toxicity index of drug B;

[0145] P B —Percentage content of agent B in the mixture, expressed as percentage (%).

[0146]

[0147] In the formula:

[0148] CTC – Cotoxicity Coefficient;

[0149] ATI – Actual Measured Toxicity Index of Mixtures;

[0150] TTI – Theoretical Toxicity Index of Mixtures.

[0151] The co-toxicity coefficients (CTC) of the compound formulations were ≥120, indicating a synergistic effect; CTC ≤80, indicating an antagonistic effect; and 80 < CTC < 120, indicating an additive effect. The results of the indoor tests are shown in the table below:

[0152] Table 1. Results of indoor bioactivity tests of compound I combined with acetamiprid on rice stem borer.

[0153]

[0154]

[0155] Table 1 shows the results of the indoor bioactivity test. It is evident that the combination of compound I and acetamiprid at appropriate mass ratios exhibits excellent control effects against rice stem borer. When the mass ratio of compound I to acetamiprid is 1:27–32:1, the co-toxicity coefficient against rice stem borer is greater than 120, indicating a synergistic effect. When the mass ratio is 1:18–16:1, the co-toxicity coefficient is greater than 130, showing a significant synergistic effect. When the mass ratio is 1:9–8:1, the co-toxicity coefficient is greater than 140, also indicating a remarkable synergistic effect.

[0156] Table 2 shows the results of indoor bioactivity tests of compound I combined with chlorfenapyr in rice stem borer.

[0157]

[0158] Table 2 shows the results of the indoor biological experiments. It is evident that combining compound I with chlorfenapyr at an appropriate mass ratio resulted in excellent control of rice stem borer. When the mass ratio of compound I to chlorfenapyr was 1:23–28:1, the co-toxicity coefficient against rice stem borer was greater than 120, indicating a synergistic effect. When the mass ratio was 1:15–20:1, the co-toxicity coefficient was greater than 130, showing a significant synergistic effect. When the mass ratio was 1:15–10:1, the co-toxicity coefficient was greater than 140, also indicating a significant synergistic effect.

[0159] Table 3 shows the results of indoor bioactivity tests of compound I combined with tetrachlorantraniliprole against rice stem borer.

[0160]

[0161]

[0162] Table 3 shows the results of the indoor biological experiments. It is evident that combining compound I with tetrachlorantraniliprole at an appropriate mass ratio resulted in excellent control of rice stem borer. When the mass ratio of compound I to tetrachlorantraniliprole was 1:35–32:1, the co-toxicity coefficient against rice stem borer was greater than 120, indicating a synergistic effect. When the mass ratio was 1:28–16:1, the co-toxicity coefficient against rice stem borer was greater than 130, showing a significant synergistic effect. When the mass ratio was 1:16–8:1, the co-toxicity coefficient against rice stem borer was greater than 140, also showing a remarkable synergistic effect.

[0163] Table 4 shows the results of indoor bioactivity tests of compound I combined with polyfluorinated diamide on rice stem borer.

[0164]

[0165] As shown in Table 4, the results of the indoor biological experiments indicate that compound I and polyfluorinated diamide, when combined at appropriate mass ratios, exhibit excellent control effects against rice stem borer. When the mass ratio of compound I to polyfluorinated diamide is 1:20–24:1, the co-toxicity coefficient is greater than 120, indicating a synergistic effect; when the mass ratio is 1:12–24:1, the co-toxicity coefficient is greater than 130, showing a significant synergistic effect; and when the mass ratio is 1:10–16:1, the co-toxicity coefficient is greater than 140, indicating a remarkable synergistic effect.

[0166] Table 5. Results of indoor bioactivity tests of compound I combined with thiocyanate on rice stem borer.

[0167]

[0168]

[0169] Table 5 shows the results of the indoor biological experiments. It is evident that compound I and thiocyanate, when combined at appropriate mass ratios, exhibit excellent control effects against rice stem borer. When the mass ratio of compound I to thiocyanate is 1:22–32:1, the co-toxicity coefficient is greater than 120, indicating a synergistic effect against rice stem borer. When the mass ratio is 1:18–25:1, the co-toxicity coefficient is greater than 130, showing a significant synergistic effect. When the mass ratio is 1:18–14:1, the co-toxicity coefficient is greater than 140, also indicating a significant synergistic effect.

[0170] Table 6 shows the results of indoor bioactivity tests of compound I combined with thiocyclamide on rice stem borer.

[0171]

[0172] Table 6 shows the results of the indoor bioactivity tests. It is evident that the combination of compound I and thiocyclam at an appropriate mass ratio exhibits excellent control effects against the rice stem borer. When the mass ratio of compound I to thiocyclam is 1:25–32:1, the co-toxicity coefficient against the rice stem borer is greater than 120, indicating a synergistic effect. When the mass ratio is 1:15–32:1, the co-toxicity coefficient is greater than 130, showing a significant synergistic effect. When the mass ratio is 1:15–24:1, the co-toxicity coefficient is greater than 140, also indicating a significant synergistic effect.

[0173] Example 2: Field efficacy test of pesticides for controlling rice stem borer

[0174] Experimental site: Qinghe Village, Jingkou Township, Nanchang County, Nanchang City, Jiangxi Province. Rice is grown year-round in the experimental site. The experimental target is the rice stem borer. The rice variety is Huanghuazhan. The experimental site has convenient irrigation and drainage and moderate soil fertility.

[0175] Experimental methods: The experiment included 14 treatments, 13 of which were pesticide treatments, with water spraying serving as a blank control. Each treatment was replicated four times in a randomized block design, with each plot measuring 50 m². 2 A 0.5m isolation zone was set up between the plots. The pesticide was applied during the peak hatching period of the rice stem borer eggs, and there was no rainfall on the day of application and for 3 days afterward. According to the concentration requirements of different pesticides, the weighed pesticides for each test plot were first stirred evenly in a small amount of water, and then the required amount of water was added to the total volume of the prepared solution for each plot. After dilution, the pesticide was diluted with 600L / hm² of water using a 3WBD-18 backpack electric sprayer. 2 The entire rice plant was then sprayed with the pesticide evenly once, while the control plot was sprayed with the same amount of water. No other insecticides were used during the experiment, and all other agricultural operations were managed according to normal production methods.

[0176] Experimental investigation: 21 days after application of the pesticide, parallel skip sampling was conducted at 5 points in each plot. Five rice clumps were investigated in each plot to determine the number of dead hearts and the total number of plants.

[0177] Methods for calculating drug efficacy:

[0178]

[0179] The results of the field efficacy trials are shown in the table below:

[0180] Table 7 Results of field efficacy trials for controlling rice stem borer.

[0181]

[0182] Safety investigation: No phytotoxicity was observed in any of the treatment groups during the field trial, and no adverse effects were found on the surrounding environment or other beneficial organisms in the test area, indicating that the tested agents were safe for rice growth at the supplied dosage.

[0183] The results (see Table 7) showed that the rapid and sustained effects of each compound formulation in controlling rice stem borer were significantly better than those of other agents. The 22% Formula I compound·thiocyclophosphamide suspension (5:6) had the highest control efficacy, at 96.00%.

[0184] Example 3: Field efficacy test for controlling fall armyworm

[0185] Experimental site: cornfield in Juyang Village, Gongji Town, Taihe County, Fuyang City, Anhui Province. The soil in the experimental field is sandy loam, the ground is flat, the soil fertility is moderate, and the irrigation and drainage are convenient. The corn plant spacing is 20cm, and one seed is sown per hole. The planting management is the same as that of corn in the local area.

[0186] Experimental Design: The experiment used a randomized block design with 14 treatments, each with 4 replicates, and a plot area of ​​45 m². 2 .

[0187] Experimental Methods: At the start of the experiment, the maize was in the tasseling stage. The pesticide was applied according to the experimental design using a backpack sprayer. The dosage of the pesticide applied was the active ingredient dosage. The water consumption for each treatment was 450 L / hm². 2 All experimental plots had uniform cultivation and water and fertilizer management conditions.

[0188] Experimental survey: The diagonal sampling method was used for the survey. Five points were surveyed in each plot, with 20 plants at each point, for a total of 100 plants. All surveyed plants were marked. The initial insect population was surveyed before spraying, and the number of live insects was surveyed 3, 7, and 14 days after spraying. The insect population reduction rate and control effect were calculated according to the following formula.

[0189] Methods for calculating drug efficacy:

[0190]

[0191] The results of the field efficacy trials are shown in the table below:

[0192] Table 8 Results of field efficacy trials for controlling fall armyworm.

[0193]

[0194] Field efficacy trials showed that the insecticidal composition of the present invention has a good control effect on fall armyworm. Preparation Example 7: 24% Formula I compound chlorfenapyr water-dispersible granules (5:1); Preparation Example 14: 30% Formula I compound polyflufenican wettable powder (5:1); Preparation Example 2: 25% Formula I compound pyraclostrobin water-dispersible granules (2:3); Preparation Example 20: 8% Formula I compound thiocarbamate emulsifiable concentrate (7:1); Preparation Example 17: 8% Formula I compound thiocarbamate emulsifiable concentrate (7:1); Preparation Example 9... The control efficacy of 27% Formula I compound·tetrachlorfenapyr suspension (1:1) was 82.90%, 87.89%, 85.51%, 89.12%, 86.42%, and 90.62% three days after application, showing good rapid effect. Fourteen days after application, the efficacy of each compound preparation was 90.05%, 90.23%, 87.52%, 93.22%, 93.23%, and 96.61%, with a relatively long duration of effect.

[0195] In summary, through indoor toxicity testing and field efficacy trials, it can be seen that the insecticidal composition of the present invention has a good control effect on lepidopteran pests, is safe for target crops, and has significant control efficacy. It is superior to single agents in delaying the development of resistance and prolonging the duration of action.

[0196] Although this application describes specific embodiments in detail with the aid of examples, the disclosure of this application can be modified and substituted in various ways. However, it should be understood that the disclosure of this application is not limited to the specific form disclosed. Rather, the disclosure of this application covers all modifications, equivalents, and substitutions within the scope of the disclosure of this application, the scope of which is defined by the appended claims and their legal equivalents.

Claims

1. An insecticidal composition containing an amide-based insecticide, characterized in that, The insecticidal composition comprises active ingredient A and active ingredient B, wherein active ingredient A is a compound of formula I: The active ingredient B is an amide insecticide, which is any one of chlorfenapyr, tetrachlorfenapyr, polyflufenoxam, thiofenazate, and thiocyclophosphamide; the mass ratio of active ingredient A to active ingredient B is 1:40 to 40:

1.

2. The insecticidal composition according to claim 1, characterized in that, The active ingredient B is chlorfenapyr, and the mass ratio of active ingredient A to active ingredient B is 1:23 to 28:

1. The active ingredient B is tetrachlorantraniliprole, and the mass ratio of active ingredient A to active ingredient B is 1:35 to 32:1; The active ingredient B is polyfluoride diamide, and the mass ratio of active ingredient A to active ingredient B is 1:20 to 24:

1. The active ingredient B is thiocyanate, and the mass ratio of active ingredient A to active ingredient B is 1:22 to 32:1; The active ingredient B is thiocyclam, and the mass ratio of active ingredient A to active ingredient B is 1:25 to 32:

1.

3. The insecticidal composition according to claim 2, characterized in that, The active ingredient B is chlorfenapyr, and the mass ratio of active ingredient A to active ingredient B is 1:15 to 20:1; The active ingredient B is tetrachlorantraniliprole, and the mass ratio of active ingredient A to active ingredient B is 1:28 to 16:1; The active ingredient B is polyfluoride diamide, and the mass ratio of active ingredient A to active ingredient B is 1:12 to 24:

1. The active ingredient B is thiocyanate, and the mass ratio of active ingredient A to active ingredient B is 1:18 to 25:1; The active ingredient B is thiocyclam, and the mass ratio of active ingredient A to active ingredient B is 1:15 to 32:

1.

4. The insecticidal composition according to claim 3, characterized in that, The active ingredient B is chlorfluazuron, and the mass ratio of active ingredient A to active ingredient B is 1:15 to 10:

1. The active ingredient B is tetrachlorantraniliprole, and the mass ratio of active ingredient A to active ingredient B is 1:16 to 8:1; The active ingredient B is polyfluoride diamide, and the mass ratio of active ingredient A to active ingredient B is 1:10 to 16:

1. The active ingredient B is thiocyanate, and the mass ratio of active ingredient A to active ingredient B is 1:18 to 14:1; The active ingredient B is thiocyclam, and the mass ratio of active ingredient A to active ingredient B is 1:15 to 24:

1.

5. The insecticidal composition according to claim 1, characterized in that, In addition to the active ingredient, the insecticidal composition also includes other pesticide-acceptable adjuvants selected from one or more of dispersants, wetting agents, emulsifiers, stabilizers, antifreeze agents, defoamers, preservatives, thickeners, solvents, organic acids, and dispersion media.

6. The insecticidal composition according to claim 1, characterized in that, The formulation of the insecticidal composition is prepared in one or more of the following forms: emulsifiable concentrate, microemulsion, soluble liquid, suspension concentrate, aqueous solution, water emulsion, ultra-low volume liquid, dispersible oil suspension, water-dispersible granules, or wettable powder.

7. The use of the insecticidal composition according to any one of claims 1-6 in the control of plant pests.

8. The application according to claim 7, characterized in that, The plant pests mentioned are lepidopteran pests.

9. The application according to claim 8, characterized in that, The lepidopteran pests mentioned are cotton bollworm, beet armyworm, rice stem borer, diamondback moth, and cabbage caterpillar.

10. The application according to claim 7, characterized in that, The insecticidal composition is applied to pests and the medium in which they occur.

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