An animal-derived compound fermented skin-rejuvenating protein peptide and its preparation method

By synergistic fermentation of bovine collagen and fish protein and the design of a composite coating layer of edible gelatin and chondroitin sulfate, the problems of stability and bioavailability of protein peptides in skin care products have been solved, achieving long-term stability and effective penetration of active ingredients.

CN121102053BActive Publication Date: 2026-06-30SHANDONG LONGBEI BIOTECHNOLOGY CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHANDONG LONGBEI BIOTECHNOLOGY CO LTD
Filing Date
2025-11-13
Publication Date
2026-06-30

AI Technical Summary

Technical Problem

Existing protein peptide materials suffer from poor stability and low bioavailability in skincare products, leading to rapid degradation of active ingredients and difficulty in effectively penetrating the skin barrier.

Method used

The core of the fermented protein peptide is prepared by synergistic fermentation of bovine collagen and fish protein using a core-shell structure design. It is then protected by a composite coating layer composed of edible gelatin and chondroitin sulfate, and a stable coating layer structure is formed by cross-linking and solidification treatment with transglutaminase.

Benefits of technology

It significantly improves the stability and bioavailability of protein peptides, ensuring that the active ingredients remain active during storage and use, and achieving effective skin penetration and sustained-release effects.

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Abstract

This invention belongs to the field of bioactive protein peptide materials, and provides an animal-derived composite fermented skin-rejuvenating protein peptide and its preparation method. This invention uses bovine collagen and fish protein co-fermentation to prepare a protein peptide core, with an outer coating of an edible gelatin and chondroitin sulfate composite layer. Through a core-shell structure design with cross-linking and solidification by glutamine transaminase, it achieves excellent performance with a small molecule peptide core of 500-1500 Da, a stable coating layer with a coating rate of 80-99%, a glycine-proline-hydroxyproline sequence collagen peptide fragment ratio of 30-60%, and a pH-responsive swelling ratio of 1.5-3.0. This solves the technical problems of poor stability and low bioavailability of traditional protein peptides, and has broad application value in the skin care industry.
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Citation Information

Patent Citations

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