Formulations containing hydroxypinacolone retinoates

Abstract

A formulation for use as a medicament for the prevention and / or treatment of skin dysfunction in humans, comprising or consisting of (a) a hydroxypinacolone retinoate (I), and optionally (b) at least one C1-C6 alkyl monoester and / or diester of a dicarboxylic acid and / or (c) at least one antioxidant.

Description

TECHNICAL FIELD

[0001] The present invention relates to the field of cosmetics and to new anti-aging formulations and their cosmetic use for combating the functional disorders of the human skin, in particular those caused by a deficiency of extracellular matrix organization and the corresponding genetic regulation. BACKGROUND

[0002] Retinoids are defined as vitamin A derivatives based on β-ionone. They are absorbed by the human body through nutritional intake and are present in the form of animal-derived retinol and retinyl esters or plant-derived carotenoids. Retinoids have various functions depending on the tissue and active form. In particular, their functions in different tissues depend on the respective retinoid derivative and retinoic acid stereoisomer, for example, the visual function is promoted by the combination of retinal with rhodopsin in the cells of the retina, while tissue differentiation, for example skin epidermis differentiation, is influenced by the binding of retinoic acid (RA) stereoisomers to nuclear receptors in the respective tissue and the activation of the regulation of gene expression. Here, 9-cis RA acts mainly as a ligand for the retinoid-X receptor RXR, while the retinoic acid receptor RAR binds both 9-cis RA and all-trans RA (ATRA) [1, 2].

[0003] Since retinoids are hydrophobic, they need to be transported in the aqueous tissue environment by retinoid binding proteins. Retinoid binding proteins are divided according to their appearance in the blood plasma into retinol binding protein (RBP 4), interstitial retinol binding protein (RBP 3) and cellular retinol binding proteins (CRBPs or RBP 1, RBP2, RBP 5 and RBP 7). These transport proteins not only facilitate the solubility of retinoids, but also protect them from oxidation. In addition, the cellular retinoic acid binding protein (CRABP) mediates the interaction between RA and its receptors RXR and RAR, thus giving CRABP the properties of a coactivator. When the RAR receptor binds to RA, a conformational change occurs, which allows it to heterodimerize with other receptors, such as RXR, LXR and PPARg, among others. This promiscuity of the RAR receptor mediates the pleiotropic effects of RA in various tissues. For example, the subunit of the heterodimeric complex changes with the differentiation status of keratinocytes, where RARa / RXRa dominates in the basal layer and RARg / RXRa in the suprabasal upper layer. In addition to its function of gene expression regulation, RA also exhibits non-transcriptional pathway activity through RAR and RXR activation, which is different from their activity as transcription factors. For example, RARa forms a complex with the G protein alpha Q (Gaq) coupled receptor in lipid rafts to respond to RA and activate the p38 MAPK signaling pathway [3], and it binds the PI3K subunit RA dependently, thus activating AKT, which subsequently activates ERK1 / 2 [4].

[0004] As mentioned above, retinoids affect the differentiation process, in particular, they are essential for keratinocyte differentiation, keratin and heparin-binding epidermal growth factor gene expression thereby regulate skin differentiation and barrier function. In particular, KRT4 and KRT13 are upregulated in the suprabasal layers, while KRT2 is downregulated in the stratum spinosum. In addition, cell division of basal keratinocytes is increased, leading to cell proliferation, followed by epidermal thickening [5]. Thus, vitamin A deficiency leads to skin problems, retinoids are used to treat keratinization disorders, such as epidermolysis bullosa simplex and epidermolytic ichthyosis, and also for the treatment of psoriasis and acne vulgaris [6]. During the aging process, keratinization and epidermal thickness are impaired. Retinoids are widely used in topical formulations to slow down skin phenotypes, including wrinkles, roughness, laxity, sallowness, desquamation, and dryness. It has been reported that the use of retinoids, in particular, can improve ultraviolet-induced photoaging [7]. The mechanism is that wrinkles and roughness are alleviated by upregulating collagen types I, III, and IV [8, 9]. In summary, retinoids have proven to be effective in the topical treatment of aging phenotypes as well as psoriasis and acne vulgaris. Nevertheless, recent reports still focus on their limitations and side effects. One limitation of retinoids is that their bioavailability decreases after long-term use, as the inactivation of retinoid-induced CYP26 family enzymes and other cytochrome P450 members is enhanced, while these enzymes form a negative feedback loop with their RAR / RXR signaling

[10] . This effect can lead to vitamin A deficiency, thus triggering adverse skin conditions. Other harmful side effects of retinoids are described as “retinoid reactions”, i.e. a burning sensation, itching, and erythema appear when starting to use retinoids. This can be due to the activation of the irritant receptor TRPV1 by retinoids, which decreases after adaptation to use

[11] . In addition, customers and patients have also observed symptoms such as inflammation, peeling, erythema, and dry skin after long-term use of retinoids. In summary, all these observed adverse reactions are multifaceted, and their molecular causes have not been elucidated in detail. Therefore, dermatologists and the cosmetics industry consider it necessary to develop retinoid alternatives with good efficacy but fewer adverse reactions. Here, Varani and colleagues developed a retinoid replacement with smaller irritancy and adverse reactions, i.e. phytanic acid esters

[12] . In the present study, we performed a whole transcriptome sequencing (RNA-Seq) approach to elucidate and compare the molecular effects of a stable mixture of hydroxyl phytone retinoate (HPR) with the benchmark ATRA in an in vitro 3D model. RELATED ART

[0005] WO 2019 185923A1 (SYMRISE) recommends the use of a mixture of retinol and diisopropyl adipate to improve the health of human skin.

[0006] WO 2023 025313A1 (DERMAHEALTH SHANGHAI BIOTECHNOLOGY CO LTD) discloses a composition comprising hydroxypinazone retinyl ester and retinyl propionate.

[0007] DK 202000134 U3 (BEAUTE PACIFIQUE APS) disclosed a skin cream containing hydroxypinazone retinyl ester.

[0008] CN 111388348 A (CHANGSHA DAISY BIO TECH CO LTD) relates to a composition comprising hydroxypinazone retinyl ester and retinol retinyl ester.

[0009] CN 111714400 A (GUANGDONG ZHENLIS COSMETICS CO LTD) discloses a cosmetic with anti-aging and repairing effects and a method for preparing such a cosmetic. The cosmetic includes an anti-aging and repairing substance and a cosmetic base substance, wherein the anti-aging and repairing substance is composed of the following components by weight percentage: 16-20% hydroxypinazone retinate, 13-18% ectoine, 15-18% honeysuckle polyphenol extract, 10-13% rhodioloside, 7-10% ellagic acid, and the balance being polypeptides.

[0010] CN 114588061 A (GUANGDONG CRATAEHNCHENG ZHENGCHENG) discloses an anti-aging and wrinkle-reducing composition, its preparation method, and a skin care product. This anti-aging and wrinkle-reducing composition comprises 1-15% anti-aging components, 1-15% wrinkle-reducing components, 3-30% adjuvants, water, and the balance; the anti-aging components include apple seed fermented extract, pumpkin seed fermented extract, and fig fermented extract; the wrinkle-reducing components include shea butter, hydroxypinazone retinyl ester, and small molecule peptides.

[0011] CN 115154338 A (HANGZHOU SHUCAI NETWORK TECH CO LTD) discloses a highly effective anti-aging serum and its preparation method. This highly effective anti-aging serum comprises oils, surfactants, additives, beneficial agents, and water. According to the present invention, a three-dimensional targeted anti-aging process is achieved using an anti-aging composition comprising acetyl hexapeptide-8, hydroxypinazone retinate, *Astragalus membranaceus* flower / leaf / stem extract, *Astragalus membranaceus* root extract ubiquinone (coenzyme Q10), vitamin E, and safflower seed oil.

[0012] CN 115569086 A relates to a hydroxypinazone retinate composition comprising hydroxypinazone retinate and an oil, wherein the oil is a low-polarity or non-polar oil.

[0013] CN 115177566 A (HANGZHOU SHUCAI NETWORK TECH CO LTD) discloses an enhanced hydroxypinazone retinyl ester anti-aging essence and its preparation method. The enhanced hydroxypinazone retinyl ester anti-aging essence includes oils, surfactants, additives, beneficial agents and water.

[0014] KR 20190132197 A (GIGI COSMETIC LABORATORIES LTD) provides a balanced concentrated composition for the prevention and treatment of acne, containing willowherb extract, hydroxypinazone retinate, dextran and tripeptide-1 as active ingredients. OBJECTS

[0015] Therefore, the object of this invention is to provide novel formulations for combating human skin dysfunction, particularly dysfunction associated with loss of skin firmness and elasticity caused by extracellular matrix catabolism and other degradation processes, especially through the upregulation of MMPs. Summary of the Invention

[0016] The first object of the present invention relates to a formulation for use as a medicament for the prevention and / or treatment of human skin dysfunction, comprising or consisting of the following ingredients. (a) Hydroxypinazone retinate (I) and optional (b) at least one C1-C6 alkyl monoester and / or diester of a dicarboxylic acid and / or (c) At least one antioxidant.

[0017] Next-generation sequencing whole-genome expression analysis revealed a surprising finding that, compared to retinol as a benchmark, hydroxypinazone retinate (HPR), particularly when bound to dicarboxylic acid esters, not only activated a similar subset of genes but also enhanced gene expression efficiency in gene sets involved in extracellular matrix regulation, keratin capsule, keratinization, and protein digestion and absorption.

[0018] In particular, this formulation has advantages over all-trans retinol because it better promotes the organization of the extracellular matrix and the formation of collagen, thereby strengthening the basement membrane. Furthermore, it is less irritating because it inhibits interferon-mediated signal transduction.

[0019] Furthermore, the formulations used according to the present invention can be used for the prevention and / or treatment of human skin dysfunction, for example: • Ellers-Danlos syndrome; • Skin laxity; • Elastic fibrolysis; Cellulitis; • Ligament laxity; • Loss of skin elasticity; and / or • Loss of skin firmness For example, through at least one of the following effects: • Reduces chemotaxis • Reduce ECM-receptor interaction • Upregulates protein digestion and absorption • Upregulates extracellular matrix and its tissue composition • Upregulates the expression of TIMP1, COL14A1, THBS1, SERPINB5, and CYR61 genes. • Upregulates fiber formation • Reduces collagen breakdown and extracellular matrix degradation; • Reduces the expression of MMP3, MMP10, MMP1, and MMP15 genes.

[0020] Ehlers-Danlos syndrome (EDS) is a group of 13 inherited connective tissue disorders in the current classification system. Symptoms typically include joint laxity, joint pain, elastic, velvety skin, and abnormal scarring. These symptoms may be present at birth or in early childhood. Complications may include aortic dissection, joint dislocation, scoliosis, chronic pain, or early osteoarthritis. EDS occurs due to variations in more than 19 genes at birth. The specific genes affected determine the type of EDS. Some cases are caused by new variations occurring during early development, while others are inherited in an autosomal dominant or recessive manner. Typically, these variations lead to defects in the structure or processing of collagen.

[0021] Cutis laxa, or neuromatous elephantiasis, is a rare group of connective tissue disorders in which the skin becomes inelastic, drooping and wrinkled. It is characterized by loose, sagging, wrinkled, and inelastic skin. Cutis laxa can be generalized or localized. Biopsies show a reduction and degeneration of elastic fibers in the dermis of the affected skin area. Cutis laxa is usually most noticeable on the face, leading to premature aging. Affected skin areas may thicken and darken. Furthermore, joints may become lax (overactive) due to the loosening of ligaments and tendons. When cutis laxa is severe, it can also affect internal organs. The lungs, heart (supvalvular pulmonary stenosis), intestines, or arteries may be affected by various serious damage. In some cases, hernias and bladder exstrophy may be observed. Patients may also experience a bluish tint to the whites of their eyes.

[0022] Ligament laxity is one of the causes of chronic body pain, characterized by loose ligaments. When this condition affects joints throughout the body, it is called systemic joint hyperactivity, affecting about 10% of the population and can be hereditary. The manifestations and severity of ligament laxity vary. It also doesn't always affect the whole body. Some people may have loose ligaments in their feet but not in their arms. As the name suggests, people with ligament laxity have loose ligaments. Unlike other more common conditions, a diagnosis of ligament laxity does not require the presence of loose tendons, muscles, or blood vessels, excessively loose skin, or other connective tissue problems. In hereditary connective tissue disorders associated with joint hyperactivity (such as Marfan syndrome and Ehlers-Donnell syndrome types I-III, VII, and XI), joint laxity usually appears before adulthood. However, the age of onset and degree of joint laxity vary in Marfan syndrome, and joint laxity may be limited to the hands, as in Ehlers-Donnell syndrome type I. Furthermore, ligament laxity may coexist with other body coordination conditions such as impaired motor coordination. Hydroxypinazone retinyl ester

[0023] Hydroxypinazone retinyl ester (HPR) (component a) represents a known member of the retinoid family. It is commercially available, typically as a 2% by weight solution of dimethyl isosorbide dimethyl ester. The method for synthesizing HPR is as follows: -CN112522331 A(SHANGHAI COACH TECH CO LTD) -CN114436924 A(TANGDAO THREE PEDESTRIAN CHEMISTRY LTD CO) -CN115260071 A(HUZHOU SHUOBANG BIOTECHNOLOGY CO LTD) -CN115531266 A(QUANHOU GUANGZHOU BIOTECHNOLOGY RES INST CO LTD) dicarboxylic acid ester

[0024] The formulation used may use a dicarboxylic acid ester of formula (II) as component (b). R 1 COO-(CH2) n (CH=CH) p (CH2) q COOR 2 (II) Where R 1 and R 2 Each of the following groups independently represents a straight-chain or branched alkyl or alkenyl group having 1 to 6 carbon atoms, n and q independently represent integers from 1 to 6, p is 0 or 1, and the condition is R. 1 and R 2 It cannot be hydrogen at the same time. Useful examples include methyl, ethyl, propyl, and isopropyl monoesters and diesters of succinic acid, glutaric acid, adipic acid, pimelic acid, octanoic acid, azelaic acid, sebacic acid, and maleic acid, as well as mixtures thereof. In a preferred embodiment, component (b) is diisopropyl adipate.

[0025] The formulation may contain components (a) and (b) in a weight ratio of about 1:99 to about 25:75, preferably about 2:98 to 20:80, more preferably about 5:95 to about 10:90.

[0026] In a preferred embodiment, the formulation is used in a pharmaceutical composition wherein the content of component (a) ranges from about 0.0001 to about 2% by weight, preferably from about 0.001 to about 0.5% by weight, more preferably from about 0.01 to about 0.2% by weight. The pharmaceutical composition may be a lotion, cream, spray, or ointment, all applied topically to human skin. antioxidants

[0027] The formulation used may contain an antioxidant (component c), which may be selected from tocopherol, tocopheryl acetate, tocopheryl palmitate, ascorbic acid, (deoxy)ribonucleic acid and its cleavage products, β-glucan, retinol, bisabolol, allantoin, phytanetriol, panthenol, AHA acid, amino acids, ceramides, pseudoceramides, essential oils, plant extracts, and vitamin complexes. Tocopherol is a preferred antioxidant.

[0028] The antioxidant content can be from about 0.1 to about 5% by weight, preferably from about 0.5 to about 2% by weight, based on the formulation. Cosmetic composition

[0029] Another object of the present invention relates to the non-therapeutic, cosmetic use of a formulation comprising (a) Hydroxypinazone retinate (I) and optional (b) at least one C1-C6 alkyl monoester and / or diester of a dicarboxylic acid and / or (c) At least one antioxidant.

[0030] Similarly, a cosmetic composition is required that contains a formulation comprising or consisting of the following ingredients. (a) Hydroxypinazone retinate (I) and optional (b) at least one C1-C6 alkyl monoester and / or diester of a dicarboxylic acid, and / or (c) At least one antioxidant.

[0031] With regard to the properties and weight relationships of components (a), (b), and (c), refer to the disclosure above. The most preferred formulation comprises or consists of the following components: (a) Hydroxypinazone retinate (b) diisopropyl adipate, and (c) Tocopherol.

[0032] This composition can be obtained by adding the formulation to a cosmetic matrix under stirring, optionally with gentle heating until a homogeneous product is obtained.

[0033] Cosmetic compositions can be, for example, skin care products, personal care products, sunscreens, or hair care products (for human scalp care), containing an effective amount of the formulation as defined above, such as from about 0.1 to about 10% by weight, preferably from about 0.5 to about 8% by weight, particularly from about 1 to about 5% by weight – calculated based on the composition. The composition can be, for example, a cream, lotion, spray, emulsion, ointment, gel, or mousse.

[0034] The formulations according to the present invention may contain anti-dandruff agents, anti-irritant agents, irritant inhibitors, antioxidants, astringents, antiperspirants, bactericides, antistatic agents, binders, buffers, carriers, chelating agents, cell stimulants, cleansing agents, conditioning agents, deodorants, antiperspirants, softeners, emulsifiers, enzymes, essential oils, fibers, film-forming agents, color-fixing agents, foam-forming agents, foam stabilizers, defoamers, foam promoters, gelling agents, gelling agents, hair conditioning agents, hair styling agents, hair straighteners, humectants, wetting agents, moisturizers, bleaching agents, strengthening agents, stain repellents, optical brighteners, impregnating agents, stain repellents, friction reducers, lubricants, moisturizing creams, ointments, sunscreens, plasticizers, covering agents, polishing agents, gloss agents, polymers, powders, proteins, and re-oiling agents. Agents, abrasives, silicones, hair growth agents, coolants, skin coolants, warming agents, skin warming agents, stabilizers, ultraviolet absorbers, UV filters, detergents, thickeners, vitamins, oils, waxes, fats, phospholipids, saturated fatty acids, mono- or polyunsaturated fatty acids, α-hydroxy acids, polyhydroxy fatty acids, liquefying agents, dyes, color protectants, pigments, aromatic substances, polyols, surfactants, electrolytes, organic solvents or silicone derivatives, etc., are used as additional additives and auxiliaries.

[0035] The particularly preferred cosmetic composition includes: - Antipruritic agent; - Anti-inflammatory agents; - Anti-acne agents; - Weight loss agents; - physiological cooling agents and / or; -Skin care products The following is a more detailed description. surfactants

[0036] Preferred auxiliaries and additives are anionic and / or amphoteric or zwitterionic surfactants. Nonionic and cationic surfactants may also be present in the composition. Suitable examples are mentioned in the paragraphs relating to emulsifiers. Anionic and amphoteric surfactants

[0037] Typical examples of anionic and amphoteric surfactants include: amygdalinamide propylamine oxide, amygdalinamide propyl betaine, aminopropyl lauryl glutamine, C12-15 alkanol sulfate ammonium, C12-16 alkanol sulfate ammonium, octanol polyether sulfate ammonium, glyceryl monocolate sulfate ammonium, cocoyl alcohol sulfate ammonium, cocoyl hydroxyethanesulfonate ammonium, cocoyl sarcosine ammonium, C12-15 alkanol polyether sulfate ammonium, C9-10 perfluoroalkyl sulfonate ammonium, dinonyl sulfosuccinate ammonium, dodecylbenzene sulfonate ammonium, isostearate ammonium, lauryl ether-6 carboxylate ammonium, lauryl ether-8 carboxylate ammonium, lauryl ether sulfate ammonium, lauryl ether-5 sulfate ammonium, lauryl ether-7 sulfate ammonium, lauryl ether-9 sulfate ammonium, etc. Ammonium laurate ether-12 sulfate, ammonium lauroyl sarcosine, ammonium lauryl sulfate, ammonium lauryl sulfosuccinate, ammonium myristyl ether sulfate, ammonium myristyl sulfate, ammonium nonylphenol polyether-4 sulfate, ammonium nonylphenol polyether-30 sulfate, ammonium oleate, ammonium palm kernel oil sulfate, ammonium stearate, ammonium tallowate, isostearyl hydrolyzed collagen AMPD salt, rosin (acyl) hydrolyzed collagen AMPD salt, isostearyl hydrolyzed collagen AMP salt, isostearyl hydrolyzed keratin AMP salt, isostearyl hydrolyzed soybean protein AMP salt, isostearyl hydrolyzed wheat protein AMP salt, apricot oleamidopropyl betaine, arachidic acid, hexyldecyl phosphate arginine salt, avocado oleamidopropyl betaine, avocado oil glyceryl polyether-8 ester, babassu Seed oil acid, babassu oleamide propylamine oxide, babassu oleamide propyl betaine, beeswax acid, behenamidopropyl betaine, behenamine oxide, behenyl alcohol polyether-25, behenyl alcohol polyether-30, behenic acid, behenyl betaine, bis-butyldimethylsiloxane polyglycerol-3, butylphenol polyether-5 carboxylic acid, butylphenol polyether-19 carboxylic acid, butyl dimethyl (hydroxypropyl butyl glucoside) ammonium chloride, butyl dimethyl (hydroxypropyl lauryl glucoside) ammonium chloride, butyl glucoside, butyl glucoside decanoate, butyl glucoside hydroxypropyl trimethyl ammonium chloride, butyl octanoic acid, C18-36 acid, C20-40 acid, C30-50 acid, C16-22 acid amide MEA, calcium dodecylbenzenesulfonate, calcium lauroyl taurate, C 9-16 alkyl / cycloalkanes, C10-14 alkylbenzene sulfonic acid, C12-14 alkyl di(aminoethyl)glycine HCl, C9-15 alcohol phosphate esters, Candida albicans / glucose / rapeseed oil methyl ester fermentation products, low erucic acid rapeseed oil amamidopropyl betaine, decanoic acid, hexanoic acid, hexanoyl ethyl glucoside, octanoyl / decanoyl aminopropyl betaine, octanoyl polyether-4 carboxylic acid, octanoyl polyether-6 carboxylic acid, octanoyl polyether-9 carboxylic acid, octanoic acid, octanoyl collagen amino acids, octanoyl glycine, octanoyl hydrolyzed collagen, octanoyl hydrolyzed keratin, octanoyl keratin amino acids, octanoyl silk amino acids, octyl / decyl glucoside, octyl / decyl wheat bran / straw glycosides, octyl glucoside, octyl glyceryl ether, octylpyrrolidone, carnitine, cetearyl alcohol polyether-20.Cetearyl alcohol polyether-23, Cetearyl alcohol polyether-24, Cetearyl alcohol polyether-25, Cetearyl alcohol polyether-27, Cetearyl alcohol polyether-28, Cetearyl alcohol polyether-29, Cetearyl alcohol polyether-30, Cetearyl alcohol polyether-33, Cetearyl alcohol polyether-34, Cetearyl alcohol polyether-40, Cetearyl alcohol polyether-50, Cetearyl alcohol polyether-55, Cetearyl alcohol polyether-60, Cetearyl alcohol polyether-80, Cetearyl alcohol polyether-100, Cetearyl alcohol polyether-25 carboxylic acid, Cetearyl alcohol polyether-2 phosphate, Cetearyl alcohol polyether-4 phosphorus Cetearyl ester, cetearyl alcohol polyether-5 phosphate, cetearyl alcohol polyether-10 phosphate, cetearyl alcohol polyether-20, cetearyl alcohol polyether-23, cetearyl alcohol polyether-24, cetearyl alcohol polyether-25, cetearyl alcohol polyether-30, cetearyl alcohol polyether-40, cetearyl alcohol polyether-45, cetearyl alcohol polyether-150, cetearyl alcohol polyether-8 phosphate, cetearyl alcohol polyether-10 phosphate, cetearyl alcohol polyether-20 phosphate, cetearyl oil alcohol polyether-22, cetearyl oil alcohol polyether-24, cetearyl oil alcohol polyether-25, cetearyl oil alcohol polyether-30, cetyl betaine, Chrysanthemum Sinense flower extract, C12-14 hydroxyalkyl hydroxyethyl β-alanine, C12-14 hydroxyalkyl hydroxyethyl sarcosine, cocamidoethyl betaine, cocamidopropylamine oxide, cocamidopropyl betaine amide MEA chloride, cocamidopropyl betaine, cocamidopropyl hydroxysulfonate betaine, cocamidoamine oxide, cocoaminobutyric acid, cocoaminopropionic acid, cocoyl alcohol polyether-7 carboxylic acid, cocoyl alcohol polyether-4 glucoside, cocoamphopropionic acid, cocoyl betaine amamide amphoteric propionate, cocoyl betaine, cocoyl dimethyl ammonium hydroxypropyl hydrolyzed rice protein, cocoyl dimethyl ammonium hydroxypropyl hydrolyzed soybean protein, cocoyl dimethyl ammonium hydroxypropyl hydrolyzed wheat protein, cocoyl glucoside, cocoyl glucoside hydroxypropyl trimethylammonium chloride, cocoyl hydroxysulfonate betaine, cocoyl morpholine oxide, coconut acid, coconut oil glyceryl polyether-8 Esters, cocamidopropyl betaine, cocoyl-sulfobetaine, (coconut oil / sunflower oil) amamidopropyl betaine, cocoylcholine methyl sulfate, cocoyl glutamate, cocoyl hydrolyzed collagen, cocoyl hydrolyzed keratin, cocoyl hydrolyzed oat protein, cocoyl hydrolyzed rice protein, cocoyl hydrolyzed silk, cocoyl hydrolyzed soybean protein, cocoyl hydrolyzed wheat protein, cocoyl sarcosine, corn oleic acid, cotton Cottonseed oil acid, cottonseed oil glycerol polyether-8 esters, C10-16 alkanol polyether-1, C10-16 alkanol polyether-2, C11-13 alkanol polyether-6, C11-13 alkanol polyether-9, C11-13 alkanol polyether-10, C11-15 alkanol polyether-30, C11-15 alkanol polyether-40, C12-13 alkanol polyether-1, C12-13 alkanol polyether-23C12-14 Alkyl Polyether-5, C12-14 Alkyl Polyether-9, C13-15 Alkyl Polyether-21, C14-15 Alkyl Polyether-8, C20-22 Alkyl Polyether-30, C20-40 Alkyl Polyether-40, C20-40 Alkyl Polyether-95, C22-24 Alkyl Polyether-33, C30-50 Alkyl Polyether-40, C9-11 Alkyl Polyether-6 Carboxylic Acid, C9-11 Alkyl Polyether-8 Carboxylic Acid, C11-15 Alkyl Polyether-7 Carboxylic Acid, C12-13 Alkyl Polyether-5 Carboxylic Acid, C12-13 Alkyl Polyether-7 Carboxylic Acid, C12-13 Alkyl Polyether-8 Carboxylic Acid, C12-13 Alkyl Polyether-12 Carboxylic Acid, C12-15 C12-15 Alkyl Polyether-7 Carboxylic Acid, C12-15 Alkyl Polyether-8 Carboxylic Acid, C12-15 Alkyl Polyether-12 Carboxylic Acid, C14-15 Alkyl Polyether-8 Carboxylic Acid, C6-10 Alkyl Polyether-4 Phosphate, C12-13 Alkyl Polyether-2 Phosphate, C12-13 Alkyl Polyether-10 Phosphate, C12-15 Alkyl Polyether-6 Phosphate, C12-15 Alkyl Polyether-8 Phosphate, C12-15 Alkyl Polyether-10 Phosphate, C12-16 Alkyl Polyether-6 Phosphate, C4-18 Perfluoroalkyl Ethyl Mercaptohydroxypropyl Trimethylammonium Chloride, Cocoa Fatty Acid Aminopropyl Betaine, C12-13 Alkyl Sulfate DEA Salt, C12-15 Alkyl Sulfate DEA Salt, Cetearyl Hard DEA salts of various polyol polyethers, including: 2-phosphate, cetyl sulfate, cocoamphodipropionic acid, C12-13 alkanol polyether-3-sulfate, cyclocarboxypropyl oleic acid, dodecylbenzene sulfonic acid, isostearic acid, lauryl ether sulfate, linoleic acid, methyl myristate sulfonic acid, myristyl ether sulfate, myristic acid, myristyl sulfate, 5-phosphate, 20-phosphate, PG-oleate, 7-carboxylic acid, 7-glucoside, 9-phosphate, decylamine oxide, and decyl sweetener. Caesarea, Decyl glucoside, Decyl tetradecyl alcohol polyether-30, Decyl tetradecylamine oxide, Lauryl amide-MEA sulfosuccinate diammonium, Lauryl sulfosuccinate diammonium, Oleamide-PEG-2 sulfosuccinate diammonium, Dibutoxymethane, DiC12-15 alkanol polyether-2 phosphate, DiC12-15 alkanol polyether-4 phosphate, DiC12-15 alkanol polyether-6 phosphate, DiC12-15 alkanol polyether-8 phosphate, DiC12-15 alkanol polyether-10 phosphate, Didodecyl butane tetracarboxylate, Lauryl ether sulfate diethylamine salt, Sodium diethylhexyl sulfosuccinate, Di(hydroxyethyl)C8-10 alkoxypropylamine oxide, Di(hydroxyethyl)C9-11 alkoxypropylamine oxideDi(hydroxyethyl)C12-15 alkoxypropylamine oxide, Di(hydroxyethyl)cocoamine oxide, Di(hydroxyethyl)laurylamine oxide, Di(hydroxyethyl)stearylamine oxide, Di(hydroxyethyl)tallowylamine oxide, Polydimethylsiloxane PEG-7 phosphate, Polydimethylsiloxane PEG-10 phosphate, Polydimethylsiloxane PEG / PPG-7 / 4 phosphate, Polydimethylsiloxane PEG / PPG-12 / 4 phosphate, Polydimethylsiloxane / polyglycerol-3 crosspolymer, Polydimethylsiloxane propyl PG-betaine, Dimyroxymethyl phosphate, Dioleoamide ethylhydroxyethyl Methylammonium methyl sulfate, hydrogenated coconut oil acid DIPA salt, lanolin acid DIPA salt, myristic acid DIPA salt, dipotassium capryloyl glutamate, dipotassium lauryl sulfosuccinate, dipotassium undecenoyl glutamate, disodium babassulamamide MEA-sulfosuccinate, disodium decanoyl amphoteric acid diacetate, disodium decanoyl amphoteric acid dipropionate, disodium capryloyl amphoteric acid diacetate, disodium capryloyl amphoteric acid dipropionate, disodium capryloyl glutamate, disodium cetearyl sulfosuccinate, disodium cetyl phenyl ether disulfonic acid, disodium cetyl sulfosuccinate, disodium cocamidoyl MEA-sulfosuccinate, disodium cocamidoyl MIPA Disodium PEG-4 sulfosuccinate, disodium cocamido-MIPA-sulfosuccinate, disodium cocamido-PEG-3 sulfosuccinate, disodium cocoyl alcohol polyether-3 sulfosuccinate, disodium cocoamphoyl carboxyethyl hydroxypropyl sulfonate, disodium cocoamphoyl diacetate, disodium cocoamphoyl dipropionate, disodium cocoyl glucoside sulfosuccinate, disodium cocoyl sulfosuccinate, disodium cocoyl butyl glucoside Disodium sulfosuccinate-10, disodium cocoyl glutamate, C12-14 alkanol polyether-1, disodium sulfosuccinate, C12-14 alkanol polyether-2, disodium sulfosuccinate, C12-15 alkanol polyether, disodium sulfosuccinate, C12-14 secondary alkanol polyether-3, disodium sulfosuccinate, C12-14 secondary alkanol polyether-5, disodium sulfosuccinate, C12-14 secondary alkanol polyether Disodium 7-sulfosuccinate, disodium C12-14 secondary alkanol polyether-9-sulfosuccinate, disodium C12-14 secondary alkanol polyether-12-sulfosuccinate, disodium decanol polyether-5-sulfosuccinate, disodium decanol polyether-6-sulfosuccinate, disodium decyl phenyl ether disulfonic acid, disodium dihydroxyethyl sulfosuccinoyl undecenoate, disodium dicocoyl ethylenediamine PEG-15 disulfate, hydrogenated cottonseed oil glyceryl ester sulfosuccinate Disodium succinate, disodium hydrogenated tallow glutamate, disodium hydroxydecyl sorbitan citrate, disodium isodecyl sulfosuccinate, disodium isostearamide MEA-sulfosuccinate, disodium isostearamide MIPA-sulfosuccinate, disodium isostearate diacetate, disodium isostearate dipropionate, disodium isostearyl sulfosuccinate, disodium lanolin alcohol ether-5 sulfosuccinate, disodium lauramide MEA-sulfosuccinate.Disodium lauramide MIPA ethylene glycol sulfosuccinate, disodium lauramide PEG-2 sulfosuccinate, disodium lauramide PEG-5 sulfosuccinate, disodium lauryl ether-5 carboxyamphodiacetate, disodium lauryl ether-7 citrate, disodium lauryl ether sulfosuccinate, disodium lauryl ether-6 sulfosuccinate, disodium lauryl ether-9 sulfosuccinate, disodium lauryl ether-12 sulfosuccinate, disodium lauryliminobis(hydroxypropyl)sulfonate, disodium lauryliminodiacetate, disodium lauryliminodiapropionate, disodium lauryliminodiapropionate tocopherol phosphate salt, disodium lauroylamphodiacetate, disodium lauroylamphodiapropionate, disodium N-lauroyl aspartate, disodium lauroyl glutamate. Disodium oleamide, disodium lauryl phenyl ether disulfonate, diammonium lauryl sulfosuccinate, disodium myristamide MEA-sulfosuccinate, disodium nonylphenol polyether-10 sulfosuccinate, disodium oleamide MEA sulfosuccinate, disodium oleamide MIPA sulfosuccinate, disodium oleamide PEG-2 sulfosuccinate, disodium oleoyl amphoteric dipropionate, disodium oleyl alcohol polyether-3 sulfosuccinate, disodium oleyl alcohol phosphate, disodium oleyl alcohol sulfosuccinate, disodium palmitamide PEG-2 sulfosuccinate, disodium palmitamide-PEG-2 sulfosuccinate, disodium palmitamide-2 sulfosuccinate, disodium PEG-4 cocoamide MIPA-sulfosuccinate, disodium PEG-12 polydimethylsiloxane sulfosuccinate, PEG-8 palmitoleic acid Disodium sulfosuccinate of glycerides, disodium PPG-2-isodecyl alcohol polyether-7-carboxyamphodiacetate, disodium ricinoleic acid amide MEA sulfosuccinate, disodium sitosterol polyether-14 sulfosuccinate, disodium soybean oil amphoteric diacetate, disodium stearamide MEA sulfosuccinate, disodium stearyl iminodipropionate, disodium stearyl amphoteric diacetate, disodium stearyl glutamate, disodium sulfosuccinate monoacylstearamine, disodium stearyl alcohol sulfosuccinate, disodium 2-sulfolarate, disodium 2-sulfopalactate, disodium tallow oleamide MEA sulfosuccinate, disodium tallow amide MEA sulfosuccinate, disodium tallow amphoteric diacetate, disodium tallow iminodipropionate, disodium sulfosuccinate monoacyl tallowamine, tridecanol Disodium sulfosuccinate, disodium undecenoamide MEA sulfosuccinate, disodium undecenoamide PEG-2 sulfosuccinate, disodium undecenoyl glutamate, disodium monowheat germ oleoyl MEA sulfosuccinate, disodium monowheat germ oleoyl PEG-2 sulfosuccinate, disodium wheat germ oleoyl amphoteric diacetate, cocamidoyl diacetate di-TEA salt, oleamide-2 sulfosuccinate di-TEA salt, palmitoyl aspartate di-TEA salt, sodium ditridecyl sulfosuccinate, dodecylbenzene sulfonic acid, erucamide propyl hydroxysulfobetaine, ethylhexyl alcohol polyether-3 carboxylic acid, ethyl PEG-15 cocoamine sulfate salt, octyl glyceryl ether, hexyl decanoic acid, hydrogenated coconut oil acid, hydrogenated lanolin alcohol polyether-25.Hydrogenated herring oil fatty acids, hydrogenated palmitoleic acid, hydrogenated palm kernel oil amine oxide, hydrogenated tallowic acid, hydrogenated tallow amine oxide, hydrogenated tallow betaine, hydrogenated tallow alcohol polyether-25, hydrogenated tallow glutamic acid, hydrogenated Candida albicans extract, hydroxycetyl alcohol polyether-60, hydroxyethyl acetoxymethyl ammonium PG-polydimethylsiloxane, lauryl ether sulfate hydroxyethyl butylamine salt, hydroxyethyl carboxymethyl cocamidopropylamine, hydroxyethyl hydroxypropyl C12-15 alkoxypropylamine oxide, hydroxylauryl / hydroxymyristyl betaine, hydroxystearic acid, hydroxysuccinimide C10-40 isoalkyl ester, hydroxysuccinimide C21-22 isoalkyl ester, hydroxysulfonyl betaine, IPDI / PEG-15 soybean oil amine oxide copolymer, IP DI / PEG-15 soybean oil amine ethanol sulfate copolymer, IPDI / PEG-15 soybean oil glycine ester copolymer, isocetyl alcohol polyether-30, isolaurate-4 phosphate, isopolyglycerol-3 polydimethylsiloxane, isopolyglycerol-3 polydimethylsiloxane, isopropanolamine lanolinate, isopropanolamine dodecylbenzene sulfonate, isostearamide propylamine oxide, isostearamide propyl betaine, isostearamide propyl morpholine oxide, isostearyl alcohol polyether-8, isostearyl alcohol polyether-16, isostearyl alcohol polyether-22, isostearyl alcohol polyether-25, isostearyl alcohol polyether-50, isostearic acid, isostearyl hydrolyzed collagen, jojoba oil PEG-150 esters, jojoba wax PEG-80 esters, jojoba wax PEG -120 esters, lanolin polyether-20, lanolin polyether-25, lanolin polyether-40, lanolin polyether-50, lanolin polyether-60, lanolin polyether-75, lanolin acid, lauramide propylamine oxide, lauramide propyl betaine, lauramide propyl hydroxysulfonyl betaine, laurylamine oxide, lauryl aminopropionic acid, lauryl dimethyl hydroxypropyl decyl glucoside ammonium chloride, lauryl dimethyl lauryl glucoside hydroxypropyl ammonium chloride, lauryl polyether-16, lauryl polyether-20, lauryl polyether-21, lauryl polyether-23, lauryl polyether-25, lauryl polyether-30, lauryl polyether-38, lauryl polyether-40, lauryl polyether-3 carboxylic acid, lauryl polyether-4 carboxylic acid Laureth-5 carboxylic acid, Laureth-6 carboxylic acid, Laureth-8 carboxylic acid, Laureth-10 carboxylic acid, Laureth-11 carboxylic acid, Laureth-12 carboxylic acid, Laureth-13 carboxylic acid, Laureth-14 carboxylic acid, Laureth-17 carboxylic acid, Laureth-6 citrate, Laureth-7 citrate, Laureth-1 phosphate, Laureth-2 phosphate, Laureth-3 phosphate, Laureth-4 phosphate, Laureth-7 phosphate, Laureth-8 phosphate, Laureth-7 tartrate, Lauric acid, Laurimethylenedipropylene glycol, Laurimethylenedipropionic acid, Lauroyl amphoteric dipropionic acid, Lauroyl β-aminopropionic acid, Lauroyl collagen amino acidLauroyl ethyltrimethylammonium methyl sulfate, lauroyl hydrolyzed collagen, lauroyl hydrolyzed elastin, lauroyl methyl glucamide, lauroyl sarcosine, lauroyl silk amino acids, lauryl betaine, lauryl polydimethylsiloxane / polyglycerol-3 crosspolymer, lauryl dimethyl hydroxypropyl cocoyl glucoside ammonium chloride, lauryl glucoside, lauryl glucoside hydroxypropyltrimethylammonium chloride, lauryl glycol hydroxypropyl ether, lauryl hydroxysulfonyl betaine, lauryl malicamide, lauryl methyl glucosamine, (lauryl / nutmeg) diol hydroxypropyl ether, (lauryl / nutmeg) wheat bran / straw glycosides, lauryl polyglycerol-3 polydimethylsiloxane ethyl polydimethylsiloxane, lauryl pyrrolidone, lauryl dimethyl sulfonyl betaine, linoleic acid. Linolenic acid, linoleic acid, lysine cocoate, macadamia seed oil glyceryl polyether-8 esters, magnesium cocoyl ether sulfate, magnesium cocoyl sulfate, magnesium isododecylphenyl sulfonate, magnesium lauryl ether-11 carboxylate, magnesium lauryl ether sulfate, magnesium lauryl ether-5 sulfate, magnesium lauryl ether-8 sulfate, magnesium lauryl ether-16 sulfate, magnesium lauryl ether-3 sulfosuccinate, magnesium lauryl hydroxypropyl sulfonate, magnesium lauryl sulfate, magnesium methyl cocoyl taurate, magnesium myristyl ether sulfate, magnesium oleyl ether sulfate, magnesium cocoyl sulfate / TEA salt, Mannequin glacial mud, coconut oil MEA salt, magnesium lauryl ether-6 carboxylate MEA salt, magnesium lauryl ether sulfate MEA salt, magnesium lauryl sulfate MEA salt PPG-6-Lauryl ether-7-carboxylic acid MEA salt, PPG-8-stearyl ether-7-carboxylic acid MEA salt, Undecenoic acid MEA salt, Meroxapone 108, Meroxapone 174, Meroxapone 178, Meroxapone 254, Meroxapone 255, Meroxapone 258, Meroxapone 314, MethoxyPEG-450 Amide glutaryl succinamide, MethoxyPEG-450 Amide hydroxysuccinimide succinate, MethoxyPEG-450 Maleimide, Methylmorpholine oxide, Milk amamidopropylamine oxide, Milk amamidopropyl betaine, Mink oleamidopropylamine oxide, Mink oleamidopropyl betaine, C12-15 Alkyl alcohol polyether sulfate MIPA salt, Dodecylbenzene sulfonic acid MIPA Salt, Lauryl ether sulfate MIPA salt, Lauryl sulfate MIPA salt, Mixed isopropanolamine lanolinate, Mixed isopropanolamine lauryl sulfate, Mixed isopropanolamine myristate, Morpholine oleate, Morpholine stearate, Myristyl ether-3 carboxylic acid, Myristyl ether-5 carboxylic acid, Myristyl benzyl dimethyl ammonium chloride, Myristamidopropylamine oxide, Myristamidopropyl betaine, Myristamidopropyl dimethylamine phosphate, Myristamidopropyl hydroxysulfonyl betaine, Myristamidopropyl PG-dimethylammonium chloride phosphate, Myristamine oxide, Myristyl aminopropionic acid, Myristic acid, Myristoyl ethyltrimethylammonium methyl sulfate salt, Myristoyl glutamate, Myristoyl hydrolyzed collagen, Myristoyl sarcosineMyristyl betaine, myristyl / cetylamine oxide, myristyl dimethyl hydroxypropyl cocoyl glucoside ammonium chloride, myristyl glucoside, myristyl alcohol phosphate, nonylphenol polyether-20, nonylphenol polyether-23, nonylphenol polyether-25, nonylphenol polyether-30, nonylphenol polyether-35, nonylphenol polyether-40, nonylphenol polyether-44, nonylphenol polyether-50, nonylphenol polyether-100, nonylphenol polyether-120, nonylphenol polyether-5 carboxylic acid, nonylphenol polyether-8 carboxylic acid, nonylphenol polyether-10 carboxylic acid, nonylphenol polyether-3 phosphate, nonylphenol polyether-4 phosphate, nonylphenol polyether-6 phosphate, nonylphenol polyether-9 phosphate, nonylphenol polyether-10 phosphate, dinonylphenol polyether-30, dinonylphenol polyether Dinonylphenol polyether-49, Dinonylphenol polyether-100, Dinonylphenol polyether-150, Dinonylphenol polyether-7 phosphate, Dinonylphenol polyether-8 phosphate, Dinonylphenol polyether-9 phosphate, Dinonylphenol polyether-10 phosphate, Dinonylphenol polyether-11 phosphate, Dinonylphenol polyether-15 phosphate, Dinonylphenol polyether-24 phosphate, Oat oleamide-propyl betaine, Octylphenol polyether-16, Octylphenol polyether-25, Octylphenol polyether-30, Octylphenol polyether-33, Octylphenol polyether-40, Octylphenol polyether-70, Octylphenol polyether-20 carboxylic acid, Octyldodecyl alcohol polyether-20, Octyldodecyl alcohol polyether-25, Octyldodecyl alcohol polyether-30, Oleamide-propylamine oxide, Oleamide-propyl betaine ... Aminopropyl (hydroxysulfonyl) betaine, oleylamine oxide, oleic acid, oleyl acyl hydrolyzed collagen, oleyl sarcosine, oleyl alcohol polyether-20, oleyl alcohol polyether-23, oleyl alcohol polyether-24, oleyl alcohol polyether-25, oleyl alcohol polyether-30, oleyl alcohol polyether-35, oleyl alcohol polyether-40, oleyl alcohol polyether-44, oleyl alcohol polyether-50, oleyl alcohol polyether-3 carboxylic acid, oleyl alcohol polyether-6 carboxylic acid, oleyl alcohol polyether-10 carboxylic acid, oleyl betaine, olive oil amamidopropylamine oxide, olive oil amamidopropyl betaine, oleic acid, olive oil acyl hydrolyzed wheat protein, stearate of Ophiopogon japonicus extract, ozonated oleyl alcohol polyether-10, ozonated PEG-10 oleate, ozonated PEG-14 oleate, ozonated polysorbate 80, palmitoleic acid, palmitoleyl Aminopropyl betaine, palm oil alcohol polyether-2 phosphate, palmamidopropylamine oxide, palmamidopropyl betaine, palmitoylamine oxide, palmitic acid, palmitoyl collagen amino acids, palmitoyl glycine, palmitoyl hydrolyzed collagen, palmitoyl hydrolyzed milk protein, palmitoyl hydrolyzed wheat protein, palmitoyl keratin amino acids, palmitoyl oligopeptides, palmitoyl silk amino acids, palm kernel oil, palm kernel oil oleamide-propyl betaine, peach kernel oil glycerol polyether-8 ester, arachidic acid, PEG-10 castor oil, PEG-40 castor oil, PEG-44 castor oil, PEG-50 castor oil, PEG-54 castor oil, PEG-55 castor oil, PEG-60 castor oil, PEG-80 castor oil, PEG-100 castor oilPEG-200 castor oil, PEG-11 cocamide, PEG-6 cocamide phosphate, PEG-4 cocoamine, PEG-8 cocoamine, PEG-12 cocoamine, PEG-150 disorbate, PEG-90 diisostearate, PEG-75 dilaurate, PEG-150 dilaurate, PEG-75 dioleate, PEG-150 dioleate, PEG-75 distearate, PEG-120 distearate, PEG-150 distearate, PEG-175 distearate, PEG-190 distearate, PEG-250 distearate, PEG-30 glyceryl cocoate, PEG-40 glyceryl cocoate, PEG-78 glyceryl Cocoate, PEG-80 glyceryl coconutate, PEG-30 glyceryl isostearate, PEG-40 glyceryl isostearate, PEG-50 glyceryl isostearate, PEG-60 glyceryl isostearate, PEG-90 glyceryl isostearate, PEG-23 glyceryl laurate, PEG-30 glyceryl laurate, PEG-25 glyceryl oleate, PEG-30 glyceryl oleate, PEG-30 glyceryl soybean oleate, PEG-25 glyceryl stearate, PEG-30 glyceryl stearate, PEG-40 glyceryl stearate, PEG-120 glyceryl stearate, PEG-200 glyceryl stearate, PEG-28 glyceryl shea butter, PEG-80 glyceryl shea butter, P EG-82 glyceryl triglyceride, PEG-130 glyceryl triglyceride, PEG-200 glyceryl triglyceride, PEG-45 hydrogenated castor oil, PEG-50 hydrogenated castor oil, PEG-54 hydrogenated castor oil, PEG-55 hydrogenated castor oil, PEG-60 hydrogenated castor oil, PEG-80 hydrogenated castor oil, PEG-100 hydrogenated castor oil, PEG-200 hydrogenated castor oil, PEG-30 hydrogenated lanolin, PEG-70 hydrogenated lanolin, PEG-50 hydrogenated palmitamide, PEG-2 isostearate, PEG-3 isostearate, PEG-4 isostearate, PEG-6 isostearate, PEG-8 isostearate, PEG-10 isostearate, PE G-12 isostearate, PEG-20 isostearate, PEG-30 isostearate, PEG-40 isostearate, PEG-26 jojoba acid, PEG-40 jojoba acid, PEG-15 jojoba alcohol, PEG-26 jojoba alcohol, PEG-40 jojoba alcohol, PEG-35 lanolin, PEG-40 lanolin, PEG-50 lanolin, PEG-55 lanolin, PEG-60 lanolin, PEG-70 lanolin, PEG-75 lanolin, PEG-85 lanolin, PEG-100 lanolin, PEG-150 lanolin, PEG-75 lanolin oil, PEG-2 laurylamide, PEG-3 laurylamine oxide, PEG-20 lauryl ester.PEG-32 Laurate, PEG-75 Laurate, PEG-150 Laurate, PEG-70 Mango Seed Oil Glycerides, PEG-20 Mannitol Laurate, PEG-8 Methyl Ether Polydimethylsiloxane, PEG-120 Methyl Glucoside Dioleate, PEG-80 Methyl Glucoside Laurate, PEG-120 Methyl Glucoside Trioleate, PEG-4 Lignate, PEG-30 Oleamine, PEG-20 Oleate, PEG-23 Oleate, PEG-32 Oleate, PEG-36 Oleate, PEG-75 Oleate, PEG-150 Oleate, PEG-20 Palmitate, PEG-150 Polyglycerol-2 Tristearate, PEG / PPG-28 / 21 Butyl acetate polydimethylsiloxane, PEG / PPG-24 / 18 butyl ether polydimethylsiloxane, PEG / PPG-3 / 17 copolymer, PEG / PPG-5 / 35 copolymer, PEG / PPG-8 / 55 copolymer, PEG / PPG-10 / 30 copolymer, PEG / PPG-10 / 65 copolymer, PEG / PPG-12 / 35 copolymer, PEG / PPG-16 / 17 copolymer, PEG / PPG-20 / 9 copolymer, PEG / PPG-20 / 20 copolymer, PEG / PPG-20 / 60 copolymer, PEG / PPG-20 / 65 copolymer, PEG / PPG-22 / 25 copolymer, PEG / PPG-28 PEG / PPG-30 / 35 copolymer, PEG / PPG-30 / 55 copolymer, PEG / PPG-35 / 40 copolymer, PEG / PPG-50 / 40 copolymer, PEG / PPG-150 / 35 copolymer, PEG / PPG-160 / 30 copolymer, PEG / PPG-190 / 60 copolymer, PEG / PPG-200 / 40 copolymer, PEG / PPG-300 / 55 copolymer, PEG / PPG-20 / 22 methyl ether polydimethylsiloxane, PEG-26-PPG-30 phosphate ester, PEG / PPG-4 / 2 propyl heptyl ether, PEG / PPG-6 / 2 propyl heptyl ether, PEG-7 / PPG PEG-2-propyl heptaether, PEG / PPG-8 / 2-propyl heptaether, PEG / PPG-10 / 2-propyl heptaether, PEG / PPG-14 / 2-propyl heptaether, PEG / PPG-40 / 2-propyl heptaether, PEG / PPG-10 / 2-ricinoleate, PEG / PPG-32 / 3-ricinoleate, PEG-55 propylene glycol oleate, PEG-25 propylene glycol stearate, PEG-75 propylene glycol stearate, PEG-120 propylene glycol stearate, PEG-5 rapeseed sterol, PEG-10 rapeseed sterol, PEG-40 ricinoleamide, PEG-75 shea butter glycerides, PEG-75 salsa glycerides, PEG-20 sorbitan cocoate.PEG-20 Sorbitan Isostearate, PEG-40 Sorbitan Lanolinate, PEG-75 Sorbitan Lanolinate, PEG-10 Sorbitan Laurate, PEG-40 Sorbitan Laurate, PEG-44 Sorbitan Laurate, PEG-75 Sorbitan Laurate, PEG-80 Sorbitan Laurate, PEG-20 Sorbitan Oleate, PEG-80 Sorbitan Palmitate, PEG-40 Sorbitan Stearate, PEG-60 Sorbitan Stearate, PEG-160 Sorbitan Triisostearate, PEG-40 Soy Sterol, PEG-2 Stearoamide Carboxylic Acid, PEG-9 Stearoamide Carboxylic Acid, PE G-20 stearate, PEG-23 stearate, PEG-25 stearate, PEG-30 stearate, PEG-32 stearate, PEG-35 stearate, PEG-36 stearate, PEG-40 stearate, PEG-45 stearate, PEG-50 stearate, PEG-55 stearate, PEG-75 stearate, PEG-90 stearate, PEG-100 stearate, PEG-120 stearate, PEG-150 stearate, PEG-45 stearate phosphate, PEG-20 tallow ester, PEG-50 tallow amide, PEG-2 tallow amide DEA, PEG-20 tallow ester, PEG-66 trihydroxystearate Lipids, PEG-200 Trihydroxystearin, PEG-60 Camellia Oil Glycerides, Nonanoic Acid, Pentadecylphenol Polyether-200, Phenolic Polyether-6 Phosphate, Poloxamer 105, Poloxamer 108, Poloxamer 182, Poloxamer 183, Poloxamer 184, Poloxamer 188, Poloxamer 217, Poloxamer 234, Poloxamer 235, Poloxamer 237, Poloxamer 238, Poloxamer 288, Poloxamer 334, Poloxamer 335, Poloxamer 338, Poloxamer 908, Poloxamer 1508, Polydimethylsiloxane PEG / PPG-24 / 19 Butyl Ether Silsesquioxane, Polydimethylsiloxane PPG-13 Butyl Ether Silsesquioxane, Polyglycerol Polyglycerol-6-decanoate, polyglycerol-10-dilaurate, polyglycerol-20-heptacapryate, polyglycerol-20-hexacapryate, polyglycerol-2-lauryl ether, polyglycerol-10-lauryl ether, polyglycerol-20-octaisononate, polyglycerol-6-pentacapryate, polyglycerol-10-pentacapryate, polyglycerol-3-dimethylsiloxane, polyglycerol-6-tetracapryate, polyglycerol-10-tetralauryate, polyglycerol-6-tricapryate, polyglycerol-10-trilauryate, polyquaternium-77, polyquaternium-78, polyquaternium-79, polyquaternium-80, polyquaternium-81, polyquaternium-82, Pomaderris Kumerahou flower / leaf extract, Poria cocos extract,Potassium abietic hydrolyzed collagen, potassium babassuate, potassium behenate, potassium C9-15 phosphate, potassium C11-15 phosphate, potassium C12-13 phosphate, potassium C12-14 phosphate, potassium decanoate, potassium capryloyl glutamate, potassium capryloyl hydrolyzed rice protein, potassium castor oil, potassium cocoate, potassium cocoyl glutamate, potassium cocoyl glycine, potassium cocoyl hydrolyzed casein, potassium cocoyl hydrolyzed collagen, potassium cocoyl hydrolyzed corn protein, potassium cocoyl hydrolyzed keratin, potassium cocoyl hydrolyzed oat protein, potassium cocoyl hydrolyzed potato protein, potassium cocoyl hydrolyzed rice bran protein, potassium cocoyl hydrolyzed rice protein, potassium cocoyl hydrolyzed silk, potassium cocoyl hydrolyzed soybean protein, potassium cocoyl hydrolyzed wheat protein, potassium cocoyl hydrolyzed yeast protein, potassium cocoyl P Potassium CA, Potassium Cocoyl Sarcosinate, Potassium Cocoyl Taurate, Potassium Corn Oleate, Potassium Cyclocarboxypropyl Oleate, Potassium Dihydroxyethyl Cocoamine Oxide Phosphate, Potassium Polydimethylsiloxane PEG-7 Phosphate, Potassium Dodecylbenzene Sulfonate, Potassium Hydrogenated Cocoate, Potassium Hydrogenated Palmitate, Potassium Hydrogenated Taurate, Potassium Hydroxystearate, Potassium Isostearate, Potassium Lanolinate, Potassium Laurate, Potassium Laureth-3 Carboxylate, Potassium Laureth-4 Carboxylate, Potassium Laureth-5 Carboxylate, Potassium Laureth-6 Carboxylate, Potassium Laureth-10 Carboxylate, Potassium Laureth-10 Carboxylate, Potassium Lauroyl Collagen Amino Acid, Potassium Lauroyl Glutamate, Potassium Lauroyl Hydrolyzed Collagen, Potassium Lauroyl Hydrolyzed Pea Protein, Potassium Lauroyl Hydrolyzed Soy Protein, Potassium Lauroyl PCA, Potassium Lauroyl Pea Potassium Amino Acids, Potassium Lauroyl Sarcosine, Potassium Lauroyl Silk Amino Acids, Potassium Lauroyl Wheat Amino Acids, Potassium Laureth Phosphate, Potassium Laureth Sulfate, Potassium Linoleate, Potassium Metaphosphate, Potassium Methyl Cocoyl Taurate, Potassium Myristate, Potassium Myristoyl Glutamate, Potassium Myristoyl Hydrolyzed Collagen, Potassium Octylphenol Polyether-12 Phosphate, Potassium Oleate, Potassium Oleoyl Hydrolyzed Collagen, Potassium Olive Oil, Potassium Olive Oil-Rich Oat Protein, Potassium Olive Oil-Rich Wheat Protein, Potassium Olive Oil-Rich / Lauroyl Wheat Amino Acids, Potassium Olive Oil-Rich PCA, Potassium Palmitate, Potassium Palmitate, Potassium Palmitate, Potassium Palmitate Hydrolyzed Corn Protein, Potassium Palmitate Hydrolyzed Oat Protein, Potassium Palmitate Hydrolyzed Rice Protein, Potassium Palmitate Hydrolyzed Sweet Almond Protein, Potassium Palmitate Hydrolyzed Wheat Protein, Potassium Palm Kernel Oleate Potassium arachidate, potassium rapeseed oil, potassium castor oil, potassium safflower oil, potassium soybean oil, potassium stearate, potassium stearoyl hydrolyzed collagen, potassium tallow, potassium tallow, potassium taurine, potassium taurine laurate, potassium tridecyl alcohol polyether-3 carboxylate, potassium tridecyl alcohol polyether-4 carboxylate, potassium tridecyl alcohol polyether-7 carboxylate, potassium tridecyl alcohol polyether-15 carboxylate, potassium tridecyl alcohol polyether-19 carboxylate, potassium tridecyl alcohol polyether-6 phosphate, potassium tridecyl alcohol polyether-7 phosphate, potassium camellia oil, potassium undecenoate, potassium undecenoyl hydrolyzed collagen, potassium undecenoyl hydrolyzed rice protein, PPG-30-butanol polyether-30, PPG-36-butanol polyether-36, PPG-38-butanol polyether-37, PPG-30-octyl alcohol polyether-4 phosphate esterPPG-10 Cetyl Ether Phosphate, PPG-2C9-11 Alcohol Polyether-8, PPG-1-Decanol Polyether-5, PPG-3-Decanol Polyether-2 Carboxylic Acid, PPG-30-Ethylhexanol Polyether-4 Phosphate, PPG-20-Glyceryl Polyether-30, PPG-2 Hydroxyethyl Coconut Oil / Isostearamide, PPG-2-Isodecyl Alcohol Polyether-8, PPG-2-Isodecyl Alcohol Polyether-10 PPG-2-Isodecyl alcohol polyether-18, PPG-2-Isodecyl alcohol polyether-25, PPG-4-Isodecyl alcohol polyether-10, Propyltrimethylammonium hydrolyzed collagen, Quaternary ammonium salt-24, Quaternary ammonium salt-52, Quaternary ammonium salt-87, Rapeseed oil acid, Rice bran acid, Rice bran oil glyceryl polyether-8 esters, Ricinoxane amylase-propyl betaine, Ricinoxane acid, Ricinoxane oil alcohol polyether-40, Sapindus Oahuensis fruit extract, Saponaria soapwort (Saponaria) (Officinalis) root powder, saponins, potassium soap, sodium / potassium soap, soap base, potassium soap base, sesame oil glyceryl polyether-8 esters, sesame oil amamidopropylamine oxide, sesame amamidopropyl betaine, shea butter amamidopropyl betaine, shea butter glyceryl polyether-8 esters, sodium arachidate, sodium arganampohoacetate, mulberry palm oil sodium oleate, sodium avocadoate, sodium babassu oleoylamphoacetate, sodium babassu oleate, sodium babassu oleate sulfate, sodium behenate. Sodium diethylene glycol castor oil sulfosuccinate, sodium dihydroxyethyl glycinate cocoyl glucoside cross-linked copolymer, sodium dihydroxyethyl glycinate lauryl glucoside cross-linked copolymer, sodium borage oleamidopropyl PG-dimethylammonium chloride phosphate, sodium butylphenol polyether-12 sulfate, sodium butyl glucoside hydroxypropyl phosphate, sodium C13-17 alkyl sulfonate, sodium C14-18 alkyl sulfonate, sodium C12-15 alkoxypropyliminodipropionate, sodium C10-16 alcohol sulfate, sodium C11-15 alkyl sulfate, sodium C12 -13 alkyl sulfate sodium, C12-15 alkyl sulfate sodium, C12-18 alkyl sulfate sodium, C16-20 alkyl sulfate sodium, C9-22 secondary alkyl sulfonate sodium, C14-17 secondary alkyl sulfonate sodium, sodium decanoate, sodium decanoamphoacetate, sodium decanoamphohydroxypropyl sulfonate, sodium decanoamphopropionate, sodium decanomethyl taurate, sodium octanoate, sodium octyl ether-2 carboxylate, sodium octyl ether-9 carboxylate, sodium octanoamphoacetate, sodium octanoamphohydroxypropyl sulfonate, sodium octanoamphopropionate, octanoyl glutamate Sodium octyl hydrolyzed wheat protein, sodium octyl PG-sulfonate, sodium octyl sulfonate, sodium ricinoleate, sodium cetearyl alcohol polyether-13 carboxylate, sodium cetearyl alcohol sulfate, sodium cetearyl alcohol polyether-13 carboxylate, sodium cetearyl alcohol sulfate, sodium cocamidopropyl PG-dimethylammonium chloride phosphate, sodium cocoyl aminopropionate, sodium cocoyl alcohol polyether sulfate, sodium cocoyl alcohol polyether-30 sulfate, sodium cocoa butter amphoteric acid, sodium cocoa butter ester, sodium cocoa butter amphoteric acid, sodium cocoa butter amphoteric acid, sodium cocoa butter amphoteric acid, sodium cocoa butter amphoteric hydroxypropyl sulfonate.Sodium cocoamphopropionate, Sodium cocoate, Sodium cocoyl alcohol / babassuol / adirabalol sulfate, Sodium cocoyl alcohol / babassuol sulfate, Sodium cocoyl glucoside hydroxypropyl phosphate, Sodium cocoyl glucoside hydroxypropyl sulfonate, Sodium cocoyl glucoside tartrate, Sodium cocoyl alcohol glyceryl ether sulfonate, Sodium cocoyl alcohol / hydrogenated tallow alcohol sulfate, Sodium cocoyl iminodiacetic acid, Sodium cocoyl monoglyceride sulfate, Sodium cocoyl monoglyceride sulfonate, Sodium cocoyl PG-dimethylammonium chloride phosphate, Sodium cocoyl alcohol sulfate, Sodium cocoyl alcohol sulfoacetate, Sodium cocoyl aminopropionate, Sodium cocoyl amino acid, Sodium cocoyl collagen amino acid, Sodium cocoyl glutamate, Sodium cocoyl glutamate, Sodium cocoyl glycinate, Sodium cocoyl / hydrogenated tallow glutamate Sodium cocoyl hydrolyzed collagen, sodium cocoyl hydrolyzed keratin, sodium cocoyl hydrolyzed rice protein, sodium cocoyl hydrolyzed silk, sodium cocoyl hydrolyzed soybean protein, sodium cocoyl hydrolyzed sweet almond protein, sodium cocoyl hydrolyzed wheat protein, sodium cocoyl hydrolyzed wheat protein glutamate, sodium cocoyl ethoxysulfonate, sodium cocoyl methylaminopropionate, sodium cocoyl oat amino acid, sodium cocoyl / palmitoyl / sunfloweroyl glutamate, sodium cocoyl proline, sodium cocoyl sarcosinate, sodium cocoyl taurate, sodium cocoyl threonine, sodium cocoyl wheat amino acid, sodium C12-14 olefin sulfonate, sodium C14-16 olefin sulfonate, sodium C14-18 olefin sulfonate, sodium C16-18 olefin sulfonate, sodium corn oleoyl amphoteric propionate, cotton Sodium acetate of flower seed oil, Sodium C13-15 alkanol polyether-8-butanol phosphate, Sodium C9-11 alkanol polyether-6-carboxylate, Sodium C11-15 alkanol polyether-7-carboxylate, Sodium C12-13 alkanol polyether-5-carboxylate, Sodium C12-13 alkanol polyether-8-carboxylate, Sodium C12-13 alkanol polyether-12-carboxylate, Sodium C12-15 alkanol polyether-6-carboxylate, Sodium C12-15 alkanol polyether-7-carboxylate, Sodium C12-15 alkanol polyether-8-carboxylate, Sodium C14-15 alkanol polyether-8-carboxylate, Sodium C12-14 secondary alkanol polyether-8-carboxylate, Sodium C14-15 alkanol polyether-PG sulfonate, Sodium C12-13 alkanol polyether-2-phosphate, Sodium C13-15 alkanol polyether-8-phosphate, Sodium C9-15 alkanol... Sodium polyether-3 sulfate, C10-15 sodium alkanol polyether sulfate, C10-16 sodium alkanol polyether-2 sulfate, C12-13 sodium alkanol polyether sulfate, C12-15 sodium alkanol polyether sulfate, C12-15 sodium alkanol polyether-3 sulfate, C13-15 sodium alkanol polyether-3 sulfate, C12-14 sodium secondary alkanol polyether-3 sulfate, C12-15 sodium alkanol polyether-3 sulfonate, C12-15 sodium alkanol polyether-7 sulfonate, C12-15 sodium alkanol polyether-15 sulfonate, sodium decanol polyether-2 carboxylate, sodium decanol polyether sulfate, sodium decylbenzene sulfonate, sodium decyl glucoside hydroxypropyl phosphate, sodium decyl glucoside hydroxypropyl sulfonate, sodium di(lauryl polyether-7) citrate, sodium di(lauryl polyether-10) phosphate.Sodium dilinoleamide propyl PG-dimethylammonium chloride phosphate, sodium dilinoleate, sodium di(oleyl alcohol polyether-8) phosphate, sodium dodecylbenzene sulfonate, sodium ethyl 2-sulfolarate, sodium glyceryl oleate phosphate, sodium grape seed oil dilamamide propyl PG-dimethylammonium chloride phosphate, sodium grape seed oil acylamphoacetate, sodium grape seed oil, sodium hexyl ether-4 carboxylate, hydrogenated sodium cocoate, hydrogenated cocoyl methyl hydroxyethyl sulfonate, hydrogenated sodium palmitate, hydrogenated sodium tallow, hydrogenated sodium tallow glutamate, sodium hydroxylauryl dimethylammonium ethyl phosphate, sodium palm kernel oil hydroxypropyl sulfonate, sodium hydroxypropyl phosphate decyl glucoside crosspolymer, sodium hydroxypropyl phosphate lauryl glucoside crosspolymer, sodium hydroxypropyl sulfonate cocoyl glucoside crosspolymer Sodium, sodium hydroxypropyl sulfonate decyl glucoside crosspolymer, sodium hydroxypropyl sulfonate lauryl glucoside crosspolymer, sodium hydroxystearate, sodium isostearate, sodium isostearyl alcohol polyether-6 carboxylate, sodium isostearyl alcohol polyether-11 carboxylate, sodium isostearyl amphoteric acid, sodium isostearyl amphoteric propionate, sodium N-isostearoyl methyl taurate, sodium lanolin alcohol polyether sulfate, sodium lanolinate, sodium lardate, sodium lauramide diacetate, sodium lauryl aminopropionate, sodium lauryl alcohol polyether-3 carboxylate, sodium lauryl alcohol polyether-4 carboxylate, sodium lauryl alcohol polyether-5 carboxylate, sodium lauryl alcohol polyether-6 carboxylate, sodium lauryl alcohol polyether-8 carboxylate, sodium lauryl alcohol polyether-11 carboxylate, sodium lauryl alcohol polyether-12 carboxylate, sodium lauryl alcohol polyether-13 carboxylate, lauryl alcohol Sodium lauryl ether-14 carboxylate, sodium lauryl ether-16 carboxylate, sodium lauryl ether-17 carboxylate, sodium lauryl ether sulfate, sodium lauryl ether-5 sulfate, sodium lauryl ether-7 sulfate, sodium lauryl ether-8 sulfate, sodium lauryl ether-12 sulfate, sodium lauryl ether-40 sulfate, sodium lauryl ether-7 tartrate, disodium lauryliminodipropionate, sodium lauroyl amphoteric acid, sodium lauroyl amphoteric hydroxypropyl sulfonate, sodium lauroyl PG-acetate phosphate, sodium lauroyl amphoteric propionate, sodium lauroyl aspartate, sodium lauroyl collagen amino acid, sodium lauroyl glycine propionate, sodium lauroyl hydrolyzed collagen, sodium lauroyl hydrolyzed silk, sodium lauroyl hydroxypropyl sulfonate, sodium lauroyl hydroxyethanesulfonate, sodium lauroyl... Sodium lauroyl aminopropionate, sodium lauroyl methyl hydroxyethyl sulfonate, sodium lauroyl Millet amino acid, sodium lauroyl / myristoyl aspartate, sodium lauroyl oat amino acid, sodium lauroyl sarcosine, sodium lauroyl silk amino acid, sodium lauroyl taurate, sodium lauroyl wheat amino acid, sodium lauryl di(ethylenediamino)aminoacetate, sodium lauryl glucoside carboxylate, sodium lauryl glucoside hydroxypropyl phosphate, sodium lauryl glucoside hydroxypropyl sulfonate, sodium lauryl glycol carboxylate, sodium lauryl hydroxyacetamide sulfate, disodium lauryl phosphate, sodium lauryl sulfate, sodium lauryl sulfoacetate, sodium linoleate, sodium macadamia seed oil, sodium mangoyl amphoteric acid, sodium mango seed oil ester, sodium laureth-2 sulfosuccinate / MEASodium methoxyPPG-2 acetate, sodium methyl cocoyl taurate, sodium methyl lauroyl taurate, sodium methyl myristoyl taurate, sodium methyl oleoyl taurate, sodium methyl palmitoyl taurate, sodium methyl stearyl taurate, sodium methyl 2-sulfolaurate, sodium methyl 2-sulfopalmitoate, sodium isopalmitoyl methyl taurate, sodium methyl cocoyl methyl taurate, sodium myristyl alcohol polyether sulfate, sodium myristate, sodium myristoyl amphoteric acetate, sodium myristoyl glutamate, sodium myristoyl hydrolyzed collagen, sodium myristoyl hydroxyethanesulfonate. Sodium myristoyl sarcosine, sodium myristyl sulfate, sodium nonylphenol ether-6 phosphate, sodium nonylphenol ether-9 phosphate, sodium nonylphenol ether-1 sulfate, sodium nonylphenol ether-3 sulfate, sodium nonylphenol ether-4 sulfate, sodium nonylphenol ether-6 sulfate, sodium nonylphenol ether-8 sulfate, sodium nonylphenol ether-10 sulfate, sodium nonylphenol ether-25 sulfate, sodium octylphenol ether-2 ethanesulfonate, sodium octylphenol ether-2 sulfate, sodium octylphenol ether-6 sulfate, sodium octylphenol ether-9 sulfate, sodium oleate, oil Sodium oleoylamphoacetate, sodium oleoylamphopropyl sulfonate, sodium oleoylamphopropionate, sodium oleoyl hydrolyzed collagen, sodium oleoyl ethanesulfonate, sodium oleyl alcohol polyether sulfate, sodium oleoyl methyl ethanesulfonate, sodium oleyl alcohol sulfate, sodium oleoylamphoacetate, sodium oleoyl glutamate, sodium palmitoleoylamphoacetate, sodium palmitate, sodium palmitoleate glyceryl sulfonate, sodium palmitate, sodium palmitoyl hydrolyzed collagen, sodium palmitoyl hydrolyzed wheat protein, sodium palmitoyl sarcosinate, sodium palm kernel oleate, sodium palmitoyl ethanesulfonate, sodium palmitoyl glutamate Sodium, sodium passionflower seed oil, sodium arachidonic acid, sodium arachidonic acid, PEG-6 sodium cocoamide carboxylate, PEG-8 sodium cocoamide carboxylate, PEG-4 sodium cocoamide sulfate, PEG-3 sodium lauramide carboxylate, PEG-4 sodium lauramide carboxylate, PEG-8 sodium palm oil glyceride carboxylate, pentaerythritol hydroxypropyl iminodiacetic acid sodium resin, propoxy PPG-2 sodium acetate, sodium rapeseed oil, sodium rice bran oleoylamphoacetate, sodium ricinoleate, sodium ricinoleoylamphoacetate, Sodium RoseHipsamphoacetate, Sodium Rosinate, Sodium Safflower Oil, Sodium Saffloweroyl Hydrolyzed Soybean Protein, Sodium Sesame Seed Oil, Sodium Sesame Amphoteric Acetate, Sodium Butyl Amphoteric Acetate, Sodium Soybean Oil, Sodium Soybean Oil Hydrolyzed Collagen, Sodium Stearate, Sodium Stearyl Amphoteric Acetate, Sodium Stearyl Hydroxypropyl Sulfonate, Sodium Stearyl Amphoteric Propionate, Sodium Stearyl Casein, Sodium Stearyl Glutamate, Sodium Stearyl Hyaluronic Acid, Sodium Stearyl Hydrolyzed Collagen, Sodium Stearyl Hydrolyzed Corn Protein, Sodium Stearyl Hydrolyzed Silk, Sodium Stearyl Hydrolyzed Soybean Protein, Sodium Stearyl Hydrolyzed Wheat Protein, Sodium Stearyl Whey Protein, Sodium Stearyl Methyl Hydroxyethanesulfonate, Sodium Stearyl Oat Protein, Sodium Stearyl Pea Protein, Sodium Stearyl Soybean ProteinSodium stearyl dimethyl glycinate, sodium stearyl alcohol sulfate, sodium sunflower seed oleoyl amphoteric acid, sodium subtilis lipopeptide, sodium sweet almond oleoyl amphoteric acid, sodium sweet almond oil, sodium talloyl amphoteric propionate, sodium talloate, sodium taurate oleate, sodium taurate oleate, sodium taurate oleate, sodium taurine, sodium cocoyl methyl taurate taurate, sodium laurate taurate, sodium lauroyl collagen amino acid / TEA salt, sodium lauroyl hydrolyzed collagen / TEA salt, sodium lauroyl hydrolyzed keratin / TEA salt, sodium lauroyl keratin amino acid / TEA salt, sodium undecenoyl collagen amino acid / TEA salt, sodium undecenoyl hydrolyzed collagen / TEA salt, sodium undecenoyl hydrolyzed corn gluten / TEA salt, ... Sodium undecenoyl hydrolyzed soybean protein / TEA salt, sodium undecenoyl hydrolyzed wheat protein / TEA salt, sodium theobroma grandiflorum seed oil, sodium tridecyl alcohol polyether-3 carboxylate, sodium tridecyl alcohol polyether-4 carboxylate, sodium tridecyl alcohol polyether-6 carboxylate, sodium tridecyl alcohol polyether-7 carboxylate, sodium tridecyl alcohol polyether-8 carboxylate, sodium tridecyl alcohol polyether-12 carboxylate, sodium tridecyl alcohol polyether-15 carboxylate, sodium tridecyl alcohol polyether-19 carboxylate, sodium tridecyl alcohol polyether sulfate, sodium tridecylbenzene sulfonate, sodium tridecyl alcohol sulfate, sodium trimethylolpropane hydroxypropyl iminodiacetic acid dendritic polymer, sodium undecyl alcohol polyether-5 carboxylate, sodium undecenoyl acrylate, sodium undecenoyl amphoteric acid. Sodium undecenoyl amphoteric propionate, disodium undecenoyl glutamate, sodium wheat germ oil amide amphoteric acetate, sorbitol polyether-160 tristearate, soybean oleic acid, soybean oil amamidopropylamine oxide, soybean oil amamidopropyl betaine, soybean oil glyceryl polyether-8 esters, stearamide propylamine oxide, stearamide propyl betaine, stearamide oxide, stearyl alcohol polyether-15, stearyl alcohol polyether-16, stearyl alcohol polyether-20, stearyl alcohol polyether-21, stearyl alcohol polyether-25, stearyl alcohol polyether-27, stearyl alcohol polyether-30, stearyl alcohol polyether-40, stearyl alcohol polyether-50, stearyl alcohol polyether-80, stearyl alcohol polyether-100, stearyl alcohol polyether-2 phosphate, stearyl alcohol polyether-3 phosphate, stearic acid, stearoxypropyl Trimethylammonium chloride, stearoylglutamic acid, stearoylsarcosine, stearyl betaine, stearyl dimethyl butyl glucoside hydroxypropyl ammonium chloride, stearyl dimethyl decyl glucoside hydroxypropyl ammonium chloride, stearyl dimethyl lauryl glucoside hydroxypropyl ammonium chloride, sulfated castor oil, sulfated coconut oil, sulfated glyceryl oleate, sulfated olive oil, sulfated peanut oil, sunflower oil oleamide MEA, sunflower seed oil acid, sunflower seed oil oleamide propyl hydroxyethyl dimethyl ammonium chloride, sunflower seed oil glyceryl polyether-8 esters, tallow acid, tallow aminopropylamine oxide, tallow aminopropyl betaine, tallow aminopropyl hydroxysulfonyl betaine, tallow amino oxide, tallow betaine, tallow dihydroxyethyl betaine, tallow ethyl glucoside.Abietic hydrolyzed collagen TEA salt, C12-14 alcohol phosphate TEA salt, C10-15 alkyl sulfate TEA salt, C11-15 alcohol sulfate TEA salt, C12-13 alkyl sulfate TEA salt, TEA-C12-14 alkyl sulfate TEA salt, TEA-C12-15 alkyl sulfate TEA salt, TEA C14-17 secondary alkyl sulfonic acid TEA salt, low erucic acid rapeseed oil TEA salt, cocamidodiacetic acid TEA salt, coconut oil acid TEA salt, coconut oil alcohol sulfate TEA salt, cocoyl alanine TEA salt, cocoyl glutamic acid TEA salt, cocoyl glutamine TEA salt, cocoyl glycine TEA salt, cocoyl hydrolyzed collagen TEA salt, cocoyl hydrolyzed soybean protein TEA salt, cocoyl sarcosine TEA salt, polydimethylsiloxane PEG-7 phosphate TEA salt, dodecylbenzene sulfonic acid TEA salt, hydrogenated coconut oil acid TEA salt, hydrogenated tallow glutamic acid TEA salt, isostearic acid TEA salt, TEA-isostearoyl water TEA salts of hydrolyzed collagen, lauryl aminopropionic acid, lauric acid, lauric acid / myristic acid, lauryl ether sulfate, lauroyl collagen amino acid, lauroyl glutamate, lauroyl hydrolyzed collagen, lauroyl keratin amino acid, lauroyl methylaminopropionic acid, lauroyl / myristoyl aspartic acid, lauroyl sarcosine, lauryl phosphate, lauryl sulfate, myristyl aminopropionic acid, myristic acid, myristoyl hydrolyzed collagen, oleic acid, oleoyl hydrolyzed collagen. EA salt, oleoyl sarcosine TEA salt, oleyl alcohol sulfate TEA salt, palmitic acid TEA salt, palm kernel sarcosine TEA salt, PEG-3 cocoamide sulfate TEA salt, rosinic acid TEA salt, stearic acid TEA salt, tall acid TEA salt, tridecylbenzene sulfonic acid TEA salt, undecenoic acid TEA salt, undecenoyl hydrolyzed collagen TEA salt, tetramethyldecynyl glycol, tetrasodium dicarboxyethyl stearyl sulfosuccinate, lauryl ether sulfate TIPA salt, lauryl sulfate TIPA salt, myristic acid TIPA salt, stearic acid TIPA salt, tocopheryl phosphate, trehalose undecenoate, TM-C12-15 alkanol polyether- 2-phosphate ester, TM-C12-15 alkanol polyether-6-phosphate ester, TM-C12-15 alkanol polyether-8-phosphate ester, TM-C12-15 alkanol polyether-10-phosphate ester, tridecyl alcohol polyether-20, tridecyl alcohol polyether-50, tridecyl alcohol polyether-3-carboxylic acid, tridecyl alcohol polyether-4-carboxylic acid, tridecyl alcohol polyether-7-carboxylic acid, tridecyl alcohol polyether-8-carboxylic acid, tridecyl alcohol polyether-15-carboxylic acid, tridecyl alcohol polyether-19-carboxylic acid, tridecyl alcohol polyether-10-phosphate ester, tridecylbenzene sulfonic acid, tris(lauroyl polyether-9) citrate, trimethylolpropane hydroxypropyl dihydroxyethylamine resin polymer, tris(lauroyl amphoteric PG-acetic acid sodium chloride) phosphate ester,Undecanoic acid, undecanoyl alcohol polyether-5 carboxylic acid, undecenoyl ammonium amine oxide, undecenoyl ammonium betaine, undecenoic acid, undecenoyl collagen amino acid, undecenoyl glycine, undecenoyl hydrolyzed collagen, undecenoyl wheat amino acids, undecyl glucoside, wheat germ fatty acids, wheat germ oleamidopropyl amine oxide, wheat germ oleamidopropyl betaine, Yucca Schidigera leaf / root / stem extract, Yucca Schidigera stem extract, zinc cocoyl alcohol polyether sulfate, and zinc cocoyl alcohol sulfate.

[0038] Preferably, it is selected from one or more compounds selected from sodium lauryl ether sulfate, cocamidopropyl betaine, sodium coamphoacetate, cocoyl glucoside, and ammonium lauryl sulfosuccinate.

[0039] The percentage content of surfactant in the formulation may be 0.1 to 10% by weight, preferably 0.5 to 5% by weight, based on the formulation. Nonionic surfactants

[0040] Alkyl alcohols. The added nonionic surfactant is preferably alkoxylated and / or propoxylated, particularly preferably a primary alcohol containing 8-18 carbon atoms per mole of alcohol and an average of 1-12 moles of ethylene oxide (EO) and / or 1-10 moles of propylene oxide (PO). Particularly preferred are C8-C alcohols with a degree of ethoxylation of 2-10, preferably 3-8, and / or a degree of propoxylation of 1-6, preferably 1.5-5. 16 - Alcohol alkoxylates, with ethoxylation and / or propoxylation of C being advantageous. 10 -C 15 - Alcohol alkoxylates, especially C 12 -C 14 Alcohol alkoxylates. The degrees of ethoxylation and propoxylation constitute a statistical average, which may be an integer or a fraction for a particular product. Preferred alcohol ethoxylates and propoxylates have a narrow homologue distribution (narrow range ethoxylate / propoxylate, NRE / NRP). In addition to these nonionic surfactants, fatty alcohols having more than 12EO can also be used. Examples include (butter) fatty alcohols having 14EO, 16EO, 20EO, 25EO, 30EO, or 40EO.

[0041] Alkyl glycosides In addition, as an extra nonionic surfactant, RO(G) can be added. xAlkyl glycosides, for example as compounds, particularly with nonionic surfactants, wherein R is a straight-chain or methyl-branched, especially 2-methyl-branched, aliphatic group having 8 to 22, preferably 12 to 18 carbon atoms, and G represents a monosaccharide unit having 5 or 6 carbon atoms, preferably glucose. The degree of glycosylation x, which defines the distribution of monosaccharides and oligosaccharides, is a value between 1 and 10, preferably between 1.1 and 1.4.

[0042] Fatty acid ester alkoxylated compounds. Another preferred class of nonionic surfactants, used either alone or in combination with other nonionic surfactants, particularly with alkoxylated fatty alcohols and / or alkyl glycosides, are alkoxylated, preferably ethoxylated or ethoxylated and propoxylated fatty acid alkyl esters, preferably containing 1 to 4 carbon atoms in the alkyl chain, and more particularly, fatty acid methyl esters prepared, for example, by the method described in Japanese Patent Application JP-A-58 / 217598 or preferably by the method described in International Patent Application WO-A-90 / 13533. Particularly preferred are those containing an average of 3 to 15 EO atoms, particularly C containing about 5 to 12 EO atoms. 12 -C 18 Fatty acid methyl esters.

[0043] Amine oxides. Nonionic surfactants of the amine oxide type, such as N-cocoalkyl-N,N-dimethylamine oxide and N-tartratealkyl-N,N-dihydroxyethylamine oxide, as well as fatty acid chain alkanolamides, are also suitable. The amount of these nonionic surfactants is preferably no greater than the amount of ethoxylated fatty alcohol, especially no more than half of it.

[0044] Gemini surfactants. Other surfactants are so-called gemini surfactants. Generally, these compounds refer to compounds containing two hydrophilic groups and two hydrophobic groups per molecule. These groups are typically separated by "spacers." These spacers are usually carbon chains, long enough to allow the hydrophilic groups sufficient distance to function independently. These surfactants are typically characterized by very low critical concentrations and a significant reduction in the surface tension of water. However, in special cases, gemini surfactants refer not only to dimer but also to trimer surfactants. Suitable gemini surfactants are, for example, sulfated hydroxyl mixed ethers according to German patent application DE 4321022A1, or dimerol-bis- and trimerol-tri-sulfates and ether sulfates according to International patent application 96 / 23768A1. According to German patent application DE 19513391 A1, the end-capped dimer and trimer mixed ethers are characterized by their bifunctionality and multifunctionality. Geminid polyhydroxy fatty acid amides or polyhydroxy fatty acid amides, such as those described in international patent applications WO 95 / 19953A1, WO 95 / 19954A1 and WO 95 / 19955A1, may also be used. cationic surfactants

[0045] Tetraalkyl quaternary ammonium salts. Cationic surfactants in aqueous solution contain hydrophobic polymer groups required for the surface activity of the dissociated cation. An important representative of cationic surfactants is the general formula (R...). 1 R 2 R 3 R 4 N + )X - Tetraalkyl quaternary ammonium salts. Among them, R... 1 Represents C1-C8 alkyl (alkene) groups, R 2 R 3 and R 4 Each group independently represents an alkyl (alkene) group containing 1 to 22 carbon atoms. X is a counterion, preferably from halogens, alkyl sulfates, and alkyl carbonates. Cationic surfactants are particularly preferred, wherein the nitrogen atom is replaced by two long acyl groups and two short alkyl (alkene) groups.

[0046] Ester quaternary ammonium salts. Cationic surfactants, particularly those used as auxiliary surfactants in this invention, are represented by the aforementioned ester quaternary ammonium salts. Ester quaternary ammonium salts are generally understood as quaternized fatty acid triethanolamine ester salts. These are known compounds that can be obtained by relevant methods of organic chemistry. Reference can be made to International Patent Application WO 91 / 01295A1, in which triethanolamine is partially esterified with a fatty acid in the presence of hypophosphite, air is passed into the reaction mixture, and then the mixture is quaternized bulkly with dimethyl sulfate or ethylene oxide. Furthermore, German Patent DE 4308794 C1 describes a method for preparing solid ester quaternary ammonium salts, wherein the quaternization of triethanolamine esters is carried out in the presence of a suitable dispersant, preferably a fatty alcohol.

[0047] A typical example of an ester quaternary ammonium salt suitably used according to the invention is a product whose acyl group is derived from a monocarboxylic acid corresponding to the formula RCOOH, wherein RCO is an acyl group containing 6 to 10 carbon atoms, and the amino group is triethanolamine (TEA). Examples of such monocarboxylic acids are hexanoic acid, octanoic acid, decanoic acid, and technical mixtures thereof, such as, for example, so-called head fractionated fatty acids. Preferred ester quaternary ammonium salts are those whose acyl group is derived from a monocarboxylic acid containing 8 to 10 carbon atoms. Other ester quaternary ammonium salts are those products whose acyl group is derived from dicarboxylic acids such as malonic acid, succinic acid, maleic acid, fumaric acid, glutaric acid, sorbic acid, pimelic acid, azelaic acid, sebacic acid, and / or dodecanoic acid, but adipic acid is preferred. In summary, preferred ester quaternary ammonium salts are those whose acyl group is derived from a mixture of monocarboxylic acids and adipic acid containing 6 to 22 carbon atoms. In the final ester quaternary ammonium salt, the molar ratio of monocarboxylic acid to dicarboxylic acid is 1:99 to 99:1, and preferably 50:50 to 90:10, and particularly 70:30 to 80:20. Besides quaternized fatty acid triethanolamine esters, other suitable ester quaternary ammonium salts are mixtures of mono / dicarboxylic acids with diethanolalkylamine or 1,2-dihydroxypropyldialkylamine. Esters can be obtained by mixing fatty acids and the corresponding triglycerides with the corresponding dicarboxylic acids. One such method, which can be considered representative of the relevant prior art, is described in European Patent EP 0750606 B1. For the production of quaternized esters, the molar ratio of the mixture of mono and dicarboxylic acids and triethanolamine—based on the available carboxyl group functions—can be 1.1:1 to 3:1. Considering the properties of ester quaternary ammonium salts, ratios that have proven particularly advantageous are 1.2:1 to 2.2:1, and preferably 1.5:1 to 1.9:1. Preferred ester quaternary ammonium salts are technical mixtures of mono-, di-, and tri-esters with an average degree of esterification of 1.5 to 1.9. Amphoteric surfactants

[0048] Internal ammonium salts. Amphoteric or zwitterionic surfactants possess a variety of functional groups that can ionize in aqueous solutions and thus—depending on the medium conditions—endow compounds with anionic or cationic properties (see DIN 53900, July 1972). Near their isoelectric point (approximately pH 4), amphoteric surfactants form internal salts, thus becoming weakly soluble or insoluble in water. Amphoteric surfactants are further subdivided into amphoteric compounds and internal ammonium salts, the latter exhibiting amphoteric behavior in solution. Amphoteric compounds are amphoteric electrolytes, i.e., compounds possessing both acidic and basic hydrophilic groups, and therefore exhibiting acidic or basic behavior depending on the conditions. In particular, internal ammonium salts are known surfactants produced primarily by the carboxylation of amine compounds, preferably by carboxylmethylation. The starting material is preferably condensed with a halocarboxylic acid or its salt, especially sodium chloroacetate, forming one mole of salt per mole of internal ammonium salt. Addition to unsaturated carboxylic acids, such as acrylic acid, is also possible. Suitable examples of internal ammonium salts are carboxylation products of secondary amines, especially tertiary amines, corresponding to the general formula R. 1 R2 R 3 N-(CH2) q COOX, where R 1 It is an alkyl group having 6-22 carbon atoms, R 2 It is hydrogen or an alkyl group containing 1-4 carbon atoms, R 3 It is an alkyl group containing 1-4 carbon atoms, q is a number from 1 to 6, and X is an alkali metal and / or alkaline earth metal or ammonium. Typical examples are hexylmethylamine, hexyldimethylamine, octyldimethylamine, decyldimethylamine, C 12 / 14 -Cocoyl dimethylamine, myristyl dimethylamine, cetyl dimethylamine, stearyl dimethylamine, stearyl ethyl methylamine, oleyl dimethylamine, C 16 / 18 - Tallow alkyl dimethylamine and their industrial mixtures, and in particular carboxymethylated products of dodecyl methylamine, dodecyl dimethylamine, dodecyl ethyl methylamine and their industrial mixtures.

[0049] Alkylamide inner ammonium salts. Other suitable inner ammonium salts are carboxyl alkylated products of amamide amines, corresponding to the general formula R. 1 CO(R 3 (R) 4 )-NH-(CH2) p -N-(CH2) q COOX, where R 1 CO is an aliphatic acyl group having 6-22 carbon atoms and 0 or 1 to 3 double bonds, R 2 It is hydrogen or an alkyl group having 1-4 carbon atoms, R 3 It is an alkyl group having 1-4 carbon atoms, where P is a number from 1 to 6, q is a number from 1 to 3, and X is an alkali metal and / or alkaline earth metal or ammonium. Typical examples are fatty acids having 6-22 carbon atoms, such as hexanoic acid, octanoic acid, capric acid, lauric acid, myristic acid, palmitic acid, palmitoleic acid, stearic acid, isostearic acid, oleic acid, transoleic acid, phellandrene, linoleic acid, linolenic acid, tung oil, arachidonic acid, cis(9)-eicosenoic acid, behenic acid, erucic acid, and their industrial mixtures reacting with N,N-dimethylaminoethylamine, N,N-dimethylaminopropylamine, N,N-diethylaminoethylamine, and N,N-diethylaminopropylamine, the product of which is condensed with sodium chloroacetate. Commercially available products include and PK (Cognis Deutschland GmbH & Co., KG) and Betaine (Goldschmidt).

[0050] Imidazoline. Other suitable starting materials for the ammonium salt used for the purposes of this invention are imidazoline. These substances are also known and can be obtained, for example, by using 1 or 2 moles of C6-C 22 The product is obtained by cyclization condensation of fatty acids with polyfunctional amines such as aminoethylethanolamine (AEEA) or diethylenetriamine. The corresponding carboxylalkylated products are mixtures of different open-chain intraammonium salts. A typical example is the condensation product of the aforementioned fatty acids and AEEA, preferably an imidazoline based on lauric acid, which is subsequently intraammonized with sodium chloroacetate. Commercially available products include... (Cognis Deutschland GmbH & Co., KG). oil body

[0051] A suitable oil body, which is a component of the O / W emulsion, is, for example, based on Guerbet alcohol containing 6 to 18, preferably 8 to 10, carbon atoms, with a straight-chain C6-C... 22 - Fatty acids and straight-chain or branched C6-C 22 -Ester or branched C6-C of aliphatic alcohols 13 -Carboxylic acids with straight-chain or branched C6-C 22 - Esters of aliphatic alcohols, such as, for example, tetradecyl myristate, tetradecyl palmitate, tetradecyl stearate, tetradecyl isostearate, tetradecyl oleate, tetradecyl behenate, tetradecyl erucate, hexadecyl myristate, hexadecyl palmitate, hexadecyl stearate, hexadecyl isostearate, hexadecyl oleate, hexadecyl behenate, hexadecyl erucate, octadecyl myristate, octadecyl palmitate, octadecyl stearate, octadecyl isostearate, octadecyl oleate, octadecyl behenate, octadecyl erucate, isooctadecyl myristate, isooctadecyl palmitate, stearic acid Isooctadecyl ester, isooctadecyl isostearate, isooctadecyl oleate, isooctadecyl behenate, isooctadecyl oleate, oleyl myristate, oleyl palmitate, oleyl stearate, oleyl isostearate, oleyl oleate, oleyl behenate, oleyl erucic acid, myristate docosyl ester, palmitate docosyl ester, stearate docosyl isostearate, isostearate docosyl ester, oleate docosyl ester, behenate docosyl ester, myristate mustard ester, palmitate mustard ester, stearate mustard ester, isostearate mustard ester, oleate mustard ester, behenate mustard ester, and mustard ester. Additionally, linear C6-C is suitable. 22 - Fatty acids and branched-chain alcohols, especially esters of 2-ethylhexanol, C 18 -C 38 -alkyl hydroxycarboxylic acid with straight-chain or branched C6-C 22- Esters of aliphatic alcohols, particularly dioctyl malate, straight-chain and / or branched-chain fatty acids with polyols (such as propylene glycol, dimerdiol, or trimertriol) and / or Guerbet alcohols, based on C6-C 10 - Triglycerides of fatty acids, C6-C 18 -A liquid mixture of mono- / di- / triglycerides of fatty acids, C6-C 22 - Aliphatic alcohols and / or Guerbet alcohols with aromatic carboxylic acids, especially benzoic acid esters, C2-C 12 - Dicarboxylic acids and esters of straight-chain or branched alcohols having 1 to 22 carbon atoms or polyols having 2 to 10 carbon atoms and 2 to 6 hydroxyl groups, vegetable oils, branched primary alcohols, substituted cyclohexanes, straight-chain and branched C6-C... 22 - Carbonates of aliphatic alcohols, such as dioctyl carbonate, for example Guerbet carbonates, benzoic acid, and straight-chain and / or branched C6-C atoms based on aliphatic alcohols having 6 to 18, preferably 8 to 10, carbon atoms. 22 -Esters of alcohols (e.g.) Dialkyl ethers, such as dioctyl ethers, are straight-chain or branched, symmetrical or asymmetrical, with each alkyl group having 6 to 22 carbon atoms. Ring-opening products of epoxidized fatty acid esters and polyols, silicone oils (cyclodimethylsiloxane, silicone methyl silicone oil grade, etc.) and / or aliphatic hydrocarbons or cycloalkanes, such as squalane, squalene or dialkylcyclohexane. emulsifier

[0052] Other nonionic or cationic surfactants can also be added to formulations as emulsifiers, including, for example: • 2 to 30 moles of ethylene oxide and / or 0 to 5 moles of propylene oxide with straight-chain C 8-22 Aliphatic alcohols, and C 12-22 Addition products of fatty acids and alkylphenols having 8-15 carbon atoms in the alkyl group; • The C10 of the addition products of 1 to 30 moles of ethylene oxide to glycerol 12 / 18 Fatty acid monoesters and diesters; • Saturated and unsaturated fatty acid mono- and diesters containing 6 to 22 carbon atoms and dehydrated sorbitol mono- and diesters and their ethylene oxide addition products; • Addition products of 15 to 60 moles of ethylene oxide with castor oil and / or hydrogenated castor oil; • Polyol esters, especially polyglycerol esters, such as polyglycerol polyricinoleate, polyglycerol poly-12-hydroxystearate, or polyglycerol dimeric oleoisostearate. Mixtures of several such compounds are also applicable; • Addition products of 2 to 15 moles of ethylene oxide with castor oil and / or hydrogenated castor oil; • Based on straight chain, branched chain, unsaturated or saturated C 6 / 22 Fatty acids, ricinoleic acid and 12-hydroxystearic acid and glycerol, polyglycerol, pentaerythritol, dipentaerythritol, sugar alcohols (e.g., sorbitol), alkyl glucosides (e.g., methyl glucoside, butyl glucoside, lauryl glucoside) and polyglucosides (e.g., cellulose) are esters. • Mono-, di-, and trialkyl phosphates, as well as mono-, di-, and / or tri-PEG alkyl phosphates and their salts; • Lanolin alcohols; • Polysiloxane / polyalkyl polyether copolymers and their derivatives; • Mixed esters of pentaerythritol, fatty acids, citric acid and fatty alcohols and / or C 6-22 Fatty acids, methyl glucose, and polyols, preferably a mixture of glycerol or polyglycerol esters. Alkyl and / or alkenyl oligosaccharides; Polydiols and • Glyceryl carbonate.

[0053] Ethylene oxide and / or propylene oxide addition products of aliphatic alcohols, fatty acids, and alkylphenols, as well as glycerol mono- and diesters and anhydrous sorbitol mono- and diesters of fatty acids or castor oil, are known commercially available products. Here, we refer to homologous mixtures whose average degree of alkoxylation corresponds to the ratio of ethylene oxide and / or propylene oxide to the matrix in the addition reaction. The C1 of the ethylene oxide-glycerol addition product... 12 / 18 Fatty acid monoesters and diesters are known to be used as fat enriching agents in cosmetic formulations. Preferred emulsifiers are listed in detail below:

[0054] Metaglycerides. Typical examples of suitable metaglycerides are glyceryl monostearate, glyceryl distearate, hydroxystearate, hydroxystearate distearate, isostearyl monostearate, isostearyl distearate, glyceryl monostearate, glyceryl distearate, ricinoleic acid monostearate, ricinoleic acid distearate, linoleic acid monostearate, linoleic acid distearate, erucic acid monostearate, erucic acid distearate, glyceryl monostearate, glyceryl distearate, glyceryl monostearate, glyceryl distearate, glyceryl monostearate, glyceryl distearate, glyceryl monostearate, glyceryl distearate, glyceryl monostearate, glyceryl distearate, glyceryl monostearate, glyceryl distearate, glyceryl distearate, glyceryl monostearate, glyceryl distearate, glyceryl distearate, glyceryl monostearate, glyceryl distearate, glyceryl distearate, mixed esters of citric acid and stearic acid or oleic acid with glycerol, and their technical-grade mixtures still containing small amounts of triglycerides derived from the production process. Addition products of 1 to 30, preferably 5 to 10 moles of ethylene oxide with the above metaglycerides are also suitable.

[0055] Sorbitol esters. Suitable sorbitol esters include sorbitol monoisostearate, sorbitol sesquiisostearate, sorbitol diisostearate, sorbitol triisostearate, sorbitol monooleate, sorbitol sesquioleate, sorbitol dioleate, sorbitol trioleate, sorbitol monoerucic acid ester, sorbitol sesquierucic acid ester, sorbitol dierucic acid ester, sorbitol trierucic acid ester, sorbitol monoricinoleate, sorbitol sesquierucic acid ester, sorbitol diricinoleate, sorbitol triricinoleate, and sorbitol monoricinoleate. Monohydroxy stearate, sorbitan sesquihydroxy stearate, sorbitan dihydroxy stearate, sorbitan trihydroxy stearate, sorbitan monotartrate, sorbitan sesquitartrate, sorbitan ditartrate, sorbitan tritartrate, sorbitan monocitrate, sorbitan sesquicitrate, sorbitan dicitrate, sorbitan tricitrate, sorbitan monomaleate, sorbitan sesquimaleate, sorbitan dimaleate, sorbitan trimaleate, and technical-grade mixtures thereof. Addition products of 1 to 30, preferably 5 to 10 moles of ethylene oxide with the above-mentioned sorbitan esters are also suitable.

[0056] Polyglycerol esters. A typical example of a suitable polyglycerol ester is polyglycerol-2-dimeric hydroxystearate. Polyglycerol-3-diisostearate Polyglycerol-4 isostearate Polyglycerol-3 oleate, diisostearoyl polyglycerol-3 diisostearoate Polyglycerol-3-methylglucose distearate Polyglycerol-3 beeswax Polyglycerol-4-decanoate (Polyglycerol decanoate T2010 / 90), Polyglycerol-3-Cetyl Ether Polyglycerol-3 distearate and polyglycerol polyricinoleate Polyglyceryl dimerate isostearate esters and mixtures thereof. Other examples of suitable polyol esters include monoesters, diesters, and tripesters formed by esterification of lauric acid, coconut oil acid, tartrate acid, palmitic acid, stearic acid, oleic acid, behenic acid, etc., with trimethylolpropane or pentaerythritol, these fatty acid esters optionally reacting with 1 to 30 moles of ethylene oxide.

[0057] Alkyl and / or alkenyl oligosaccharides. Alkyl and / or alkenyl oligosaccharides, their preparation, and uses are known in the prior art. They are prepared, in particular, by reacting glucose or oligosaccharides with a primary alcohol containing 8 to 18 carbon atoms. In terms of glycosidic residues, monosaccharides, wherein the cyclic sugar residues are linked to the fatty alcohol by glycosidic bonds, and oligosaccharides with an oligomerization degree preferably up to about 8 are suitable. The oligomerization degree is a statistical average of the homologous distribution commonly used in products of this technology.

[0058] Tetraalkyl quaternary ammonium salts. Cationic surfactants are active surfactants that dissociate in aqueous solution, with the cationic moiety containing hydrophobic polymeric groups that impart surface activity. An important representative of cationic surfactants is the general formula (R...). 1 R 2 R 3 R 4 N + )X - A tetraalkyl quaternary ammonium salt. Where R1 represents a C1-C8 alkyl (alkene) group, R... 2 R 3 and R 4 Each of these groups independently represents an alkyl (alkene) group containing 1 to 22 carbon atoms. X is a counterion, preferably a self-halide, alkyl sulfate, or alkyl carbonate. Cationic surfactants are particularly preferred, wherein the nitrogen atom is replaced by two long-chain acyl groups and two short-chain alkyl (alkene) groups.

[0059] Ester quaternary ammonium salts. A class of cationic surfactants particularly suitable for use as co-surfactants in this invention are so-called ester quaternary ammonium salts. Ester quaternary ammonium salts generally refer to quaternized fatty acid triethanolamine ester salts. They are known compounds that can be obtained by relevant methods of organic synthetic chemistry. In this regard, reference is made to International Patent Application WO 91 / 01295A1, in which triethanolamine is partially esterified with fatty acids in the presence of hypophosphite, air is passed through the reaction mixture, and then the bulk is quaternized with dimethyl sulfate or ethylene oxide. In addition, German Patent DE 4308794 C1 discloses a method for preparing solid ester quaternary ammonium salts, wherein the quaternization of triethanolamine esters is carried out in the presence of a suitable dispersant, preferably a fatty alcohol.

[0060] A typical example of an ester quaternary ammonium salt suitably used according to the invention is a product whose acyl component is derived from a monocarboxylic acid corresponding to the formula RCOOH, wherein RCO is an acyl group containing 6 to 10 carbon atoms, and the amino component is triethanolamine (TEA). Examples of such monocarboxylic acids are hexanoic acid, octanoic acid, decanoic acid, and technical-grade mixtures thereof, such as, for example, so-called headdicarboxylic fatty acids. Preferred ester quaternary ammonium salts are those whose acyl component is derived from a monocarboxylic acid containing 8 to 10 carbon atoms. Other ester quaternary ammonium salts are those whose acyl component is derived from dicarboxylic acids such as malonic acid, succinic acid, maleic acid, fumaric acid, glutaric acid, sorbic acid, pimelic acid, azelaic acid, sebacic acid, and / or dodecanoic acid, but those of adipic acid are preferred. Generally, ester quaternary ammonium salts are preferred whose acyl component is derived from a mixture of monocarboxylic acids containing 6 to 22 carbon atoms and adipic acid. In the final ester quaternary ammonium salt, the molar ratio of monocarboxylic acid to dicarboxylic acid is 1:99 to 99:1, and preferably 50:50 to 90:10 and more particularly 70:30 to 80:20. Besides quaternized fatty acid triethanolamine esters, other suitable ester quaternary ammonium salts are quaternized esters of mixtures of mono / dicarboxylic acids with diethanolalkylamine or 1,2-dihydroxypropyldialkylamine. The ester quaternary ammonium salt can be obtained from fatty acids and corresponding triglycerides mixed with the corresponding dicarboxylic acid. One such method, representative of the relevant prior art, is proposed by European Patent EP 0750606B1. To prepare the quaternized ester, a mixture of mono and dicarboxylic acids with triethanolamine in a molar ratio of 1.1:1 to 3:1 can be used—based on the available carboxyl functional groups. Considering the properties of the ester quaternary ammonium salt, a ratio of 1.2:1 to 2.2:1, and particularly 1.5:1 to 1.9:1, has proven particularly advantageous. Preferred ester quaternary ammonium salts are technical mixtures of mono-, di-, and tri-esters with an average degree of esterification of 1.5 to 1.9. Fat enrichment agents and consistency factors

[0061] The fat enrichment agent can be selected from substances such as lanolin and lecithin, as well as polyethoxylated or acylated lanolin and lecithin derivatives, polyol fatty acid esters, monoglycerides and fatty acid alkanolamides, among which fatty acid alkanolamides can also be used as foam stabilizers.

[0062] The main consistency factors used are aliphatic alcohols or hydroxyaliphatic alcohols containing 12 to 22, preferably 16 to 18, carbon atoms, as well as glycerides, fatty acids, or hydroxy fatty acids. These substances are preferably used in combination with alkyl oligoglucosides and / or fatty acids of the same chain length, N-methylglucamide, and / or polyglycerol poly-12-hydroxystearate. Thickeners and rheology modifiers

[0063] Suitable thickeners are polymeric thickeners, such as... Hydrophilic silica, polysaccharides, especially xanthan gum, guar gum, agar, alginate and tyloses, carboxymethyl cellulose and hydroxyethyl cellulose, and relatively high molecular weight polyethylene glycol monoesters and diesters, polyacrylates (e.g.) [Goodrich] or [Sigma]), polyacrylamide, polyvinyl alcohol and polyvinylpyrrolidone, surfactants such as ethoxylated fatty acid glycerides, fatty acids and polyols such as pentaerythritol or trimethylolpropane esters, aliphatic alcohol ethoxylates with narrow homologue distributions, and electrolytes such as sodium chloride and ammonium chloride. Film-forming agent

[0064] Suitable film-forming agents include the following types: polymer

[0065] Suitable cationic polymers are, for example, cationic cellulose derivatives, such as those available from Amerchol as PolymerJR. The names obtained are quaternized hydroxyethyl cellulose, cationic starch, diallyl ammonium salt and acrylamide copolymers, quaternized vinylpyrrolidone / vinylimidazol polymers, for example (BASF), condensates of polyethylene glycol and amines, quaternized collagen peptides, such as lauryl diammonium hydroxypropyl hydrolyzed collagen ( Grünau), quaternized wheat peptides, polyethyleneimine, cationic organosilicon polymers, such as aminopolydimethylsiloxane, adipic acid and a copolymer of dimethylaminohydroxypropyl diethylenetriamine ( Sandoz), a copolymer of acrylic acid and dimethyl diallyl ammonium chloride ( 550, Chemviron), polyamino polyamides and their crosslinked water-soluble polymers, cationic chitin derivatives, such as quaternized chitosan, optionally with microcrystalline distribution, dihaloalkanes, such as dibromobutane, condensation products with dialkylamines, such as dimethylamino-1,3-propane, cationic guar gum, such as Celanese Quaternary ammonium salt polymers, such as Miranol and can be marketed under the product name or Various polyquaternary ammonium salt types were found (e.g., 6, 7, 32, or 37).

[0066] Suitable anionic, amphoteric, amphoteric, and nonionic polymers are, for example, vinyl acetate / crotonic acid copolymers, vinylpyrrolidone / vinyl acrylate copolymers, vinyl acetate / butyl maleate / isoborneol acrylate copolymers, methyl vinyl ether / maleic anhydride copolymers and their esters, uncrosslinked and polyol-crosslinked polyacrylic acid, acrylamide propyltrimethylammonium chloride / acrylate copolymers, octylacrylamide / methyl methacrylate / tert-butylaminoethyl methacrylate / 2-hydroxypropyl methacrylate copolymers, polyvinylpyrrolidone, vinylpyrrolidone / vinyl acetate copolymers, vinylpyrrolidone / dimethylaminoethyl methacrylate / vinyl caprolactam terpolymers, and optionally derived cellulose ethers and silicone oils. Pearl wax

[0067] Suitable pearlescent waxes are, for example, alkyl glycol esters, especially ethylene glycol distearate; fatty acid alkanolamides, especially coconut fatty acid diethanolamides; glyceryl esters, especially monoglycerides of stearate; esters of poly(substituted carboxylic acids) with aliphatic alcohols having 6-22 carbon atoms, especially long-chain esters of tartaric acid; aliphatic substances having a total of at least 24 carbon atoms, such as aliphatic alcohols, aliphatic ketones, aliphatic aldehydes, aliphatic ethers and aliphatic carbonates, especially laurone and distearate; fatty acids such as stearic acid, hydroxystearic acid or behenic acid; ring-opening products of epoxyolefins having 12-22 carbon atoms and aliphatic alcohols having 12-22 carbon atoms and / or polyols having 2-15 carbon atoms and 2-10 hydroxyl groups, and mixtures thereof. silicone

[0068] Suitable silicones are selected from the group including: theophylline methylsilanol mannouronate, acetyl methionyl methylsilanol elastomeric esters, acrylates / behenol acrylates, acrylates / polydimethylsiloxane methacrylate copolymers, acrylates / behenol methacrylates / polydimethylsiloxane methacrylate copolymers, acrylates / dihydroxypropyl polydimethylsiloxane crosspolymers, acrylates / polydimethylsiloxane copolymers, acrylates / polydimethylsiloxane methacrylates / ethylhexyl acrylate copolymers, acrylates / polydimethylsiloxane alcohol acrylate copolymers, and acrylates / ethylhexyl acrylates / polydimethylsiloxane methacrylates. Ester copolymers, acrylates / octylacrylamide / diphenylamino-terminated polydimethylsiloxane copolymers, acrylates / polytrimethylsiloxane methacrylate copolymers, acrylates / propyl polytrimethylsiloxane methacrylate copolymers, acrylates / stearyl acrylate / polydimethylsiloxane methacrylate copolymers, acrylates / tridecyl acrylate / triethoxysilylpropanol methacrylate / polydimethylsiloxane methacrylate copolymers, acrylates / trifluoropropyl methacrylate / polytrimethylsiloxane methacrylate copolymers, aminodipropylpolydimethylsiloxane, aminoethylaminopropylpolydimethylsiloxane, aminopropylpolydimethylsiloxane, amino Propylphenyl polytrimethylsiloxane, aminopropyltriethoxysilane, polydimethylsiloxane PEG-7 ammonium sulfate, amino-terminated polydimethylsiloxane, amino-terminated polydimethylsiloxane hydroxystearate, amino-terminated polydimethylsiloxane / silsesquioxane copolymer, ascorbic acid carboxydecyltrisiloxane, ascorbic acid methylsilanol pectate, behenoxy polydimethylsiloxane, behenyltrimethylammonium polydimethylsiloxane PEG-8 phthalate, behenyl polydimethylsiloxane, bisaminoPEG / PPG-41 / 3 aminoethyl PG-propyl polydimethylsiloxane, bis-aminopropyl / ethoxyaminopropyl polydimethylsiloxane, bis(butyl benzoate) diaminotriazine aminopropyltrisiloxane, bis-butyl polydimethylsiloxane polyglycerol- 3. Bis-butoxy amino-terminated polydimethylsiloxane / PEG-60 copolymer, bis(C13-15alkoxy)hydroxybutamido amino-terminated polydimethylsiloxane, bis(C13-15alkoxy)PG-amino-terminated polydimethylsiloxane, bis-(C1-8 alkyllauroyl lysine decyl formamide) polydimethylsiloxane, bis-cetylcetyl polydimethylsiloxane, bis-cetyl / PEG-8cetyl PEG-8 polydimethylsiloxane, bis-diphenylethyl dipolysiloxane, bis-ethylethyl polymethylsiloxane, bis-glucamide ethyl-aminopropyl polydimethylsiloxane, bis-hydrogen polydimethylsiloxane, bis-hydroxyethoxypropyl polydimethylsiloxane bis-hydroxylauryl, polydimethylsiloxane / IPDI copolymer,Bis-hydroxy / methoxyamino-terminated polydimethylsiloxane, bis-hydroxypropyl polydimethylsiloxane behenate, bis-hydroxypropyl polydimethylsiloxane / SMDI copolymer, bis-isobutyl PEG-14 / amino-terminated polydimethylsiloxane copolymer, bis-isobutyl PEG-15 / amino-terminated polydimethylsiloxane copolymer, bis-isobutyl PEG / PPG-20 / 35 / amino-terminated polydimethylsiloxane copolymer, bis-isobutyl PEG / PPG-10 / 7 / polydimethylsiloxane copolymer, bis-isobutyl PEG-24 / PPG-7 / polydimethylsiloxane copolymer, bis-PEG-1 polydimethylsiloxane, bis-PEG-4 polydimethylsiloxane, bis-PEG-8 polydimethylsiloxane, bis-PEG -12 polydimethylsiloxane, bis-PEG-20 polydimethylsiloxane, bis-PEG-12 polydimethylsiloxane beeswax ester, bis-PEG-12 polydimethylsiloxane candelilla wax ester, bis-PEG-15 polydimethylsiloxane / IPDI copolymer, bis-PEG-15 methyl ether polydimethylsiloxane, bis-PEG-18 methyl ether dimethylsiloxane, bis-PEG / PPG-14 / 14 polydimethylsiloxane, bis-PEG / PPG-15 / 5 polydimethylsiloxane, bis-PEG / PPG-18 / 6 polydimethylsiloxane, bis-PEG / PPG-20 / 20 polydimethylsiloxane, bis-PEG / PPG-16 / 16PEG / PPG-16 / 16 polydimethylsiloxane Dimethylsiloxane, bis-PEG / PPG-20 / 5PEG / PPG-20 / 5 polydimethylsiloxane, bisphenylhexamethylsiloxane, bis-phenylpropyl polydimethylsiloxane, bispolyethylene polydimethylsiloxane, bis(polyglycerol-3-oxyphenylpropyl) polydimethylsiloxane, bis-(polyglycerol-7-oxyphenylpropyl) polydimethylsiloxane, bis-PPG-15 polydimethylsiloxane / IPDI copolymer, bis(PPG-7 undecenol polyether-21) polydimethylsiloxane, bis-stearyl polydimethylsiloxane, bis-trimethoxysilylethyltetramethyldisiloxyethyl polydimethylsiloxane, bis-vinyl polydimethylsiloxane, bis-vinyl polydimethylsiloxane / polydimethylsiloxane copolymer, borage seed oil PEG -7 Polydimethylsiloxane esters, butyl acrylate / C6-14 perfluoroalkyl ethanol acrylate / mercaptopropyl polydimethylsiloxane copolymer, butyl acrylate / hydroxypropyl polydimethylsiloxane acrylate copolymer, butyl polydimethylsiloxane acrylate / cyclohexyl methacrylate / ethylhexyl acrylate copolymer, butyl polydimethylsiloxane methacrylate / methyl methacrylate crosspolymer, tert-butyldimethylsiloxane grape seed extract, butyl polydimethylsiloxane ethylene / propylene / ethylene norbornene copolymer, C6-8 alkylC3-6 alkyl glucoside polydimethylsiloxane, C20-24 alkyl polydimethylsiloxane, C24-28 alkyl polydimethylsiloxane, C26-28 alkyl polydimethylsiloxaneC30-45 alkyl polydimethylsiloxane, C30-60 alkyl polydimethylsiloxane, C32 alkyl polydimethylsiloxane, C30-45 alkyl polydimethylsiloxane / polycyclohexene oxide crosslinked polymer, C26-28 alkanol dimethylsilane polypropylsilsesquioxane, C30-45 alkanol dimethylsilane polypropylsilsesquioxane, C20-24 alkyl polymethylsiloxane, C24-28 alkyl polymethylsiloxane, C26-28 alkyl polymethylsiloxane, C30-45 alkyl polymethylsiloxane, C20-28 alkyl perfluorinated polymethylsiloxane Decylethoxy polydimethylsiloxane, C26-54 alkyltetradecyl polydimethylsiloxane, octyl polydimethylsiloxane, octyl polydimethylsiloxane ethoxyglucoside, octyl polymethylsiloxane, octyl polytrimethylsiloxane, carboxydecyltrisiloxane, castor oil bis-hydroxypropyl polydimethylsiloxane esters, triacontyl polydimethylsiloxane, cetearyl polydimethylsiloxane crosspolymer, cetearyl polydimethylsiloxane / vinyl polydimethylsiloxane crosspolymer, cetearyl polymethylsiloxane, cetrimonium carboxydecyl PEG-8 polydimethylsiloxane Siloxane salts, Cetrimonium polydimethylsiloxane PEG-7 phthalate salts, Cetyl behenyl alcohol polydimethylsiloxane salts, Cetyl polydimethylsiloxane, Cetyl polydimethylsiloxane / bisvinyl polydimethylsiloxane crosspolymer, Cetyl hexadecyl polydimethylsiloxane, Cetyloxy polydimethylsiloxane, Cetyl PEG-8 polydimethylsiloxane, Cetyl PEG / PPG-15 / 15 butyl ether polydimethylsiloxane, Cetyl PEG / PPG-7 / 3 polydimethylsiloxane, Cetyl PEG / PPG-10 / 1 polydimethylsiloxane Dimethylsiloxane, cetyltriethylammonium polydimethylsiloxane PEG-8 phthalate, cetyltriethylammonium polydimethylsiloxane PEG-8 succinate, acetyltyrosine copper methylsilanol, PCA methylsilanol copper, C4-14 perfluoroalkyl ethoxy polydimethylsiloxane, cycloethoxy polymethylsiloxane, cycloheptane, cyclohexylsiloxane, cyclohexylsiloxane, cyclopolydimethylsiloxane, cyclopentamethoxysiloxane, cyclophenyl polymethylsiloxane, cyclotetramethylsiloxane, cyclovinyl polymethoxysilane, cystine bis-PG-propylsilanetriol, DEA PG-propyl PEG / PPG-18 / 21 polydimethylsiloxane, diisostearoyl trimethylolpropane siloxysilicate, dilauroyl trimethylolpropane siloxane alkylsilicate, di-linoleamide propyl dimethylamine polydimethylsiloxane PEG-7 phosphate, polydimethylsiloxane, polydimethylsiloxane crosspolymer, polydimethylsiloxane crosspolymer-3, polydimethylsiloxane / divinyl polydimethylsiloxane / silsesquioxane crosspolymer, polydimethylsiloxane ethoxyglucoside, polydimethylsiloxane hydroxypropyltrimethylammonium chloride, polydimethylsiloxane / mercaptopropyl polymethylsiloxane copolymer, polydimethylsiloxane PEG-15 acetate.Polydimethylsiloxane PEG-8 adipate, polydimethylsiloxane PEG-7 avocado oleate, polydimethylsiloxane PEG-8 avocado oleate, polydimethylsiloxane PEG-8 beeswax ester, polydimethylsiloxane PEG-8 benzoate, polydimethylsiloxane PEG-8 borage oleate, polydimethylsiloxane PEG-7 cocoate, polydimethylsiloxane / PEG-10 crosspolymer, polydimethylsiloxane PEG-10 / 15 crosspolymer, polydimethylsiloxane / PEG-15 crosspolymer, polydimethylsiloxane PEG-7 isostearate, polydimethylsiloxane PEG-8 isostearate, polydimethylsiloxane PEG-7 lactate, polydimethylsiloxane PEG -8 lanolinate, polydimethylsiloxane PEG-8 lauryl ester, polydimethylsiloxane PEG-8 meadowfoam seed oleate, polydimethylsiloxane PEG-7 octyl dodecyl citrate, polydimethylsiloxane PEG-7 olive oil ester, polydimethylsiloxane PEG-8 olive oil ester, polydimethylsiloxane PEG-7 phosphate, polydimethylsiloxane PEG-8 phosphate, polydimethylsiloxane PEG-10 phosphate, polydimethylsiloxane PEG-7 phthalate, polydimethylsiloxane PEG-8 phthalate, polydimethylsiloxane PEG-8 polyacrylate, polydimethylsiloxane PEG / PPG-20 / 23 benzoate, polydimethylsiloxane PEG / PPG- 7 / 4 phosphate ester, polydimethylsiloxane PEG / PPG-12 / 4 phosphate ester, polydimethylsiloxane PEG-7 succinate, polydimethylsiloxane PEG-8 succinate, polydimethylsiloxane PEG-7 sulfate, polydimethylsiloxane PEG-7 undecanoate, polydimethylsiloxane PG-diethylmethylammonium chloride, polydimethylsiloxane / phenylvinyl polydimethylsiloxane crosspolymer, polydimethylsiloxane / polyglycerol-3 crosspolymer, polydimethylsiloxane / PPG-20 crosspolymer, polydimethylsiloxane propyl ethylenediamine behenate, polydimethylsiloxane propyl PG-betaine, polydimethylsiloxane / silsesquioxane copolymer, silylated polydimethylsiloxane, polydimethyl... Siloxane / vinyl polydimethylsiloxane crosspolymer, polydimethylsiloxane / vinyltrimethylsiloxane silicate crosspolymer, polydimethylsiloxane alcohol, polydimethylsiloxane alcohol arginine, polydimethylsiloxane alcohol beeswax ester, polydimethylsiloxane alcohol behenate, polydimethylsiloxane alcohol sorbate, polydimethylsiloxane alcohol candelilla ester, polydimethylsiloxane alcohol caraway ester, polydimethylsiloxane alcohol brassinate, polydimethylsiloxane alcohol cysteine, polydimethylsiloxane alcohol derupa ester, polydimethylsiloxane alcohol fluoroalcohol dimer linoleic acid polyester, polydimethylsiloxane alcohol hydroxystearate, polydimethylsiloxane alcohol Indian hematite resin ester, polydimethylsiloxane alcohol / IPDI copolymer, polydimethylsiloxane alcohol isostearate.Polydimethylsiloxane alcohol oleate, polydimethylsiloxane alcohol lactate, polydimethylsiloxane alcohol meadowfoam seed oleate, polydimethylsiloxane alcohol methionine, polydimethylsiloxane alcohol / methylsilanol / silica ester crosspolymer, polydimethylsiloxane alcohol longleaf limonene oleate, polydimethylsiloxane alcohol panthenol, polydimethylsiloxane alcohol salicylate, polydimethylsiloxane alcohol / silica crosspolymer, polydimethylsiloxane alcohol / silsesquioxane copolymer, polydimethylsiloxane alcohol stearate, polydimethylsiloxane alcohol / stearyl polymethylsiloxane / phenyl polytrimethylsiloxane copolymer, dimethoxysilyl alkyl ethylidene diaminopropyl polydimethylsiloxane, dimethylaminopropionamide PCA polydimethylsiloxane, dimethyl Oxybenzodioxane, dimethylsilanol hyaluronic acid ester, dioleotocopherol methylsilanol, diphenylamino-terminated polydimethylsiloxane, diphenylpolydimethylsiloxane, diphenylpolydimethylsiloxane crosspolymer, diphenylpolydimethylsiloxane / vinyldiphenylpolydimethylsiloxane / silsesquioxane crosspolymer, diphenylethylbenzyloxydimethyldisiloxane, diphenylisopropylpolydimethylsiloxane, diphenylsiloxyphenyl / propylpolytrimethylsiloxane, diphenylsiloxyphenylpolytrimethylsiloxane, dipolysiloxane, disodium disuccinate of amino-terminated polydimethylsiloxane, disodium PEG-12 polydimethylsiloxane sulfosuccinate, PEG-8 lauryl polydimethylsiloxane sulfosuccinic acid Disodium ester, divinyl polydimethylsiloxane / polydimethylsiloxane copolymer, divinyl polydimethylsiloxane / polydimethylsiloxane crosspolymer, cresoltrazolium trisiloxane, ethylhexyl acrylate / VP / polydimethylsiloxane methacrylate copolymer, ethyl polymethylsiloxane, ethyl trisiloxane, fluoroC2-8 alkyl polydimethylsiloxane, glucamipropropylaminopropyl polydimethylsiloxane, 4-(2-β-pyranose glucosylsiloxy)propoxy-2-hydroxybenzophenone, glyceryl undecyl polydimethylsiloxane, glycidoxy polydimethylsiloxane, polyhexylmethylsiloxane, hexyl polydimethylsiloxane, hexyl trimethoxysilane, hydrogenated polydimethylsiloxane, hydrogen Hydrolyzed polydimethylsiloxane / octylsilsesquioxane copolymer, hydrolyzed collagen PG-propyl polydimethylsiloxane alcohol, hydrolyzed collagen PG-propylmethylsilanediol, hydrolyzed collagen PG-propylsilanetriol, hydrolyzed keratin PG-propylmethylsilanediol, hydrolyzed sesame protein PG-propylmethylsilanediol, hydrolyzed silk PG-propylmethylsilanediol, hydrolyzed silk PG-propylmethylsilanediol crosspolymer, hydrolyzed soybean protein / polydimethylsiloxane PEG-7 acetate, hydrolyzed soybean protein PG-propylmethylsilanediol, hydrolyzed plant protein PG-propylsilanetriol, hydrolyzed wheat protein / cystine bis-PG-propylsilanetriol copolymer, hydrolyzed wheat protein / polydimethylsiloxane PEG-7 acetateHydrolyzed wheat protein / polydimethylsiloxane PEG-7 phosphate copolymer, hydrolyzed wheat protein PG-propylmethylsilanediol, hydrolyzed wheat protein PG-propylsilanetriol, hydroxyethyl acetoxymethylammonium PG-polydimethylsiloxane, hydroxypropyl polydimethylsiloxane, hydroxypropyl polydimethylsiloxane behenate, hydroxypropyl polydimethylsiloxane isostearate, hydroxypropyl polydimethylsiloxane stearate, isobutyl methacrylate / bis-hydroxypropyl polydimethylsiloxane acrylate copolymer, isobutyl methacrylate / trifluoroethyl methacrylate / bis-hydroxypropyl polydimethylsiloxane acrylate copolymer, isoamyl alcohol trimethoxycinnamate trisiloxane, isopolyglycerol-3 polydimethylsiloxane, isopolyglycerol-3 polydimethylsiloxane alcohol Isopropyl titanium triisostearate / triethoxysilyl ethyl, polydimethylsiloxane crosspolymer, isostearyl carboxydecyl PEG-8 polydimethylsiloxane, lactoyl methylsilanol elastomeric ester, lauryl polydimethylsiloxane, lauryl polydimethylsiloxane PEG-15 crosspolymer, lauryl polydimethylsiloxane PEG-10 phosphate, lauryl polydimethylsiloxane / polyglycerol-3 crosspolymer, lauryl polymethylsiloxane, lauryl PEG-8 polydimethylsiloxane, lauryl PEG-10 methyl ether polydimethylsiloxane, lauryl PEG-9 polydimethylsiloxane, lauryl PEG / PPG-18 / 18 polymethylsiloxane, lauryl benzene isocyanate Propyl polymethylsiloxane, lauryl styrene-propyl polymethylsiloxane, lauryl polydimethylsiloxane / divinyl polydimethylsiloxane crosspolymer, lauryl polyglycerol-3 polydimethylsiloxane / dimethylsiloxane, lauryl polytrimethylsiloxane, linoleamide-propyl PG-dimethylammonium chloride phosphate polydimethylsiloxane, methacrylpropyltrimethoxysilane, polymethylsiloxane, methoxyamino-terminated polydimethylsiloxane / silsesquioxane copolymer, methoxycinnamoamide-propyl polysilsesquioxane, methoxycinnamoylpropyl silsesquioxane silicate, methoxyPEG-13 ethyl polysilsesquioxane, methoxyPEG / PPG-7 / 3 aminopropyl polydimethylsiloxane, methoxyPEG / PPG-2 5 / 4 polydimethylsiloxane, methoxyPEG-10propyltrimethoxysilane, methyleugenol PEG-8 polydimethylsiloxane, methyl polysiloxane emulsion, methylsilanol acetylmethionine ester, methylsilanol acetyltyrosine ester, methylsilanol ascorbate, methylsilanol carboxymethyl theophylline, methylsilanol carboxymethyl theophylline alginate, methylsilanol elastin ester, methylsilanol glycyrrhizate, methylsilanol hydroxyproline ester, methylsilanol hydroxyproline ester aspartate, methylsilanol mannouronate, methylsilanol PCA ester, methylsilanol PEG-7 glyceryl cocoate, methylsilanol / silicate crosspolymer, methylsilanol spirulina protein ester, methylsilanol tri-PEG-8 glyceryl cocoate.Methyltrimethylsiloxane, methyltrimethoxysilane, myristamidopropyl dimethylamine polydimethylsiloxane PEG-7 phosphate, myristyl polymethylsiloxane, myristyl trisiloxane, nylon-611 / polydimethylsiloxane copolymer, PCA polydimethylsiloxane, PEG-7 amino-terminated polydimethylsiloxane, PEG-8 amino-terminated polydimethylsiloxane, PEG-8 cetyl polydimethylsiloxane, PEG-3 polydimethylsiloxane, PEG-6 polydimethylsiloxane, PEG-7 polydimethylsiloxane, PEG-8 polydimethylsiloxane, PEG-9 polydimethylsiloxane, PEG-10 polydimethylsiloxane, PEG-12 polydimethylsiloxane, PEG-14 polydimethylsiloxane, PE G-17 polydimethylsiloxane, PEG-10 polydimethylsiloxane crosslinked polymer, PEG-12 polydimethylsiloxane crosslinked polymer, PEG-8 polydimethylsiloxane dimer linoleate, PEG-8 polydimethylsiloxane / dimeric linoleic acid copolymer, PEG-10 polydimethylsiloxane / vinyl polydimethylsiloxane crosslinked polymer, PEG-8 distearate methyl ammonium chloride PG-polydimethylsiloxane, PEG-10 / lauryl polydimethylsiloxane crosslinked polymer, PEG-15 / lauryl polydimethylsiloxane crosslinked polymer, PEG-15 / lauryl polydimethylsiloxane ethyl polydimethylsiloxane crosslinked polymer, PEG-8 polymethylsiloxane, PEG-6 polymethylsiloxane acetate PEG-6 methyl ether polydimethylsiloxane, PEG-7 methyl ether polydimethylsiloxane, PEG-8 methyl ether polydimethylsiloxane, PEG-9 methyl ether polydimethylsiloxane, PEG-10 methyl ether polydimethylsiloxane, PEG-11 methyl ether polydimethylsiloxane, PEG-32 methyl ether polydimethylsiloxane, PEG-8 methyl ether triethoxysilane, PEG-10 nonafluorohexyl polydimethylsiloxane copolymer, PEG-4 PEG-12 polydimethylsiloxane, PEG-8 PG cocoyl glucoside polydimethylsiloxane, PEG-9 polydimethylsiloxane ethyl polydimethylsiloxane, PEG / PPG-20 / 22 butyl ether polydimethylsiloxane, PEG / PPG-22 / 22 butyl ether polydimethylsiloxane Alkane, PEG / PPG-23 / 23 butyl ether polydimethylsiloxane, PEG / PPG-24 / 18 butyl ether polydimethylsiloxane, PEG / PPG-27 / 9 butyl ether polydimethylsiloxane, PEG / PPG-3 / 10 polydimethylsiloxane, PEG / PPG-4 / 12 polydimethylsiloxane, PEG / PPG-6 / 4 polydimethylsiloxane, PEG / PPG-6 / 11 polydimethylsiloxane, PEG / PPG-8 / 14 polydimethylsiloxane, PEG / PPG-8 / 26 polydimethylsiloxane, PEG / PPG-10 / 2 polydimethylsiloxane, PEG / PPG-12 / 16 polydimethylsiloxane, PEG / PPG-12 / 18 polydimethylsiloxanePEG / PPG-14 / 4 polydimethylsiloxane, PEG / PPG-15 / 5 polydimethylsiloxane, PEG / PPG-15 / 15 polydimethylsiloxane, PEG / PPG-16 / 2 polydimethylsiloxane, PEG / PPG-16 / 8 polydimethylsiloxane, PEG / PPG-17 / 18 polydimethylsiloxane, PEG / PPG-18 / 6 polydimethylsiloxane, PEG / PPG-18 / 12 polydimethylsiloxane, PEG / PPG-18 / 18 polydimethylsiloxane, PEG / PPG-19 / 19 polydimethylsiloxane, PEG / PPG-20 / 6 polydimethylsiloxane, PEG / PPG-20 / 15 polydimethylsiloxane, PEG / PPG-20 / 20 polydimethylsiloxane, PEG / PPG-20 / 23 polydimethylsiloxane, PEG / PPG-20 / 29 polydimethylsiloxane, PEG / PPG-22 / 23 polydimethylsiloxane, PEG / PPG-22 / 24 polydimethylsiloxane, PEG / PPG-23 / 6 polydimethylsiloxane, PEG / PPG-25 / 25 polydimethylsiloxane, PEG / PPG-27 / 27 polydimethylsiloxane, PEG / PPG-30 / 10 polydimethylsiloxane, PEG / PPG-25 / 25 polydimethylsiloxane / acrylate copolymer, PEG / PPG-20 / 22 methyl ether polydimethylsiloxane, PEG / PPG-24 / 24-Methyl ether epoxypropoxy polydimethylsiloxane, PEG / PPG-10 / 3 oil-based ether polydimethylsiloxane, PEG / PPG-5 / 3 trisiloxane, PEG-4 trifluoropropyl polydimethylsiloxane copolymer, PEG-8 trifluoropropyl polydimethylsiloxane copolymer, PEG-10 trifluoropropyl polydimethylsiloxane copolymer, PEG-8 trisiloxane, perfluorooctyltriethoxysilylethyl polymethylsiloxane, perfluorononyl polydimethylsiloxane, perfluorononyl polydimethylsiloxane / polymethylsiloxane / ammonia-terminated polydimethylsiloxane crosspolymer, perfluorononylethylcarboxydecylbenzyl polydimethylsiloxane, perfluorononylethylcarboxydecylhexadecyl polydimethylsiloxane, perfluorononylethylcarboxydecyl polydimethylsiloxane Lauryl / behenyl polydimethylsiloxane, perfluorononylethylcarboxydecyl lauryl polydimethylsiloxane, perfluorononylethylcarboxydecyl PEG-8 polydimethylsiloxane, perfluorononylethylcarboxydecyl PEG-10 polydimethylsiloxane, perfluorononylethyl polydimethylsiloxane / polymethylsiloxane copolymer, perfluorononylethyl PEG-8 polydimethylsiloxane, perfluorononylethyl stearyl polydimethylsiloxane, perfluorooctylethyl / diphenyl polydimethylsiloxane copolymer, perfluorooctylethyltriethoxysilane, perfluorooctylethanoltrimethoxysilane, perfluorooctylethyltrisiloxane, perfluorooctyltriethoxysilane, PG-amino-terminated polydimethylsiloxane, phenethyl polydimethylsiloxane, phenethyl disiloxane, phenyl polydimethylsiloxanePhenyl isopropyl polydimethylsiloxane, phenyl polymethylsiloxane, phenyl polymethylsiloxane alcohol, phenylpropyl dimethylsiloxysilicate, phenylpropyl ethyl polymethylsiloxane, phenylpropyl polytrimethylsiloxane, phenylpropyl polytrimethylsiloxane / diphenyl polymethylsiloxane, phenyl polytrimethylsiloxane, divinyldisiloxane platinum, polyacrylate-6, polydiethylsiloxane, polydimethylsiloxane / divinyl dimethylsiloxane crosspolymer, polydimethylsiloxane / polymethylsiloxane copolymer, polydimethylsiloxane PEG / PPG-24 / 19 butyl ether silsesquioxane, polydimethylsiloxane PPG-13 butyl ether silsesquioxane, polyglycerol-3 disiloxane polydimethylsiloxane Poly(glycerol-3 / lauryl polydimethylsiloxane) crosspolymer, poly(glycerol-3) polydimethylsiloxane, poly(ethylene glycol adipate) / dihydroxyethoxypropyl polydimethylsiloxane copolymer, polymethylsilsesquioxane, polymethylsilsesquioxane / trimethylsiloxysilicate, polyphenylsilsesquioxane, polypropylsilsesquioxane, polysiloxane-1, polysiloxane-2, polysiloxane-3, polysiloxane-4, polysiloxane-5, polysiloxane-6, polysiloxane-7, polysiloxane-8, polysiloxane-9, polysiloxane-10, polysiloxane-11, polysiloxane-12, polysiloxane-13, polysiloxane-14, polysiloxane-15, polysiloxane-16, polysiloxane... Polysiloxane-17, Polysiloxane-18, Polysiloxane-19, Polysiloxane-20, Polysiloxane-21, Polysiloxane-18 Cetyl Phosphate, Polysiloxane-1 Crosspolymer, Polysiloxane-18 Stearate, Polyurethane-10, Methylsiloxane PEG-7 Panthenol Phosphate Potassium, Polydimethylsiloxane PEG-7 Phosphate Potassium, PPG-12 Butyl Ether Polydimethylsiloxane, PPG-2 Polydimethylsiloxane, PPG-12 Polydimethylsiloxane, PPG-27 Polydimethylsiloxane, PPG-4 Oleyl Alcohol Polyether-10 Polydimethylsiloxane, Propyleneoxytetramethylpiperidinyl Polydimethylsiloxane, Propylene Trimethylsiloxane, Quaternary Ammonium Salt-80, Retinoxytrimethylsilane, Silane Diol Salicylate, Silane Tri Alcohols, silanetriol arginine ester, silanetriol glutamate ester, silanetriol lysine ester, silanetriol melanin ester, silanetriol trehalose ether, silica, polydimethylsiloxane silylated silica, dimethylsilylated silica, silylated silica, silicon carbide, polysiloxane quaternary ammonium salt-1, polysiloxane quaternary ammonium salt-2, polysiloxane quaternary ammonium salt-2 panthenol succinate, polysiloxane quaternary ammonium salt-3, polysiloxane quaternary ammonium salt-4, polysiloxane quaternary ammonium salt-5, polysiloxane quaternary ammonium salt-6, polysiloxane quaternary ammonium salt-7, polysiloxane quaternary ammonium salt-8, polysiloxane quaternary ammonium salt-9, polysiloxane quaternary ammonium salt-10, polysiloxane quaternary ammonium salt-11, polysiloxane quaternary ammonium salt-12, polysiloxane quaternary ammonium salt-15, polysiloxane quaternary ammonium salt-16.Polysiloxane quaternary ammonium salt-16 / epoxypropoxy polydimethylsiloxane crosspolymer, polysiloxane quaternary ammonium salt-17, polysiloxane quaternary ammonium salt-18, polysiloxane quaternary ammonium salt-19, polysiloxane quaternary ammonium salt-20, polysiloxane quaternary ammonium salt-21, polysiloxane quaternary ammonium salt-22, polysiloxane quaternary ammonium salt-24, polysiloxane quaternary ammonium salt-25, siloxane triol alginate, siloxane triol phytate, organosilicon resin, carboxydecyl PEG-8 sodium polydimethylsiloxane, polydimethylsiloxane PEG-7 sodium acetylmethane taurate, sodium dimethylsilanol hyaluronic acid ester, sodium lactate methylsilanol, sodium mannouronate methylsilanol, sodium PCA methylsilanol, PG-propyl polydimethylsiloxane thiosulfate copolymer sodium, PG-propyl Sodium thiosulfate polydimethylsiloxane, propoxyhydroxypropyl thiosulfate sodium silicate, sorbitol silanediol, soybean triethoxysilylpropyl dimethylammonium chloride, silachlor polydimethylsiloxane PEG-8 phthalate salt, stearamide propyl polydimethylsiloxane, stearyl dimethylammonium hydroxypropyl panthenol PEG-7 polydimethylsiloxane phosphate chloride, stearyl dimethylammonium hydroxypropyl PEG-7 polydimethylsiloxane phosphate chloride, stearyloxy polydimethylsiloxane, stearyloxy polymethsiloxane / polydimethylsiloxane copolymer, stearyloxy trimethylsilane, stearyl aminopropyl polymethylsiloxane, stearyl polydimethylsiloxane, stearyl alcohol / lauryl methacrylate crosspolymer, stearyl polymethylsiloxane, stearyl trimethylsiloxane Ethoxysilane, stearyl polytrimethylsiloxane, styrene / acrylate / polydimethylsiloxane acrylate crosspolymer, styrene / acrylate / polydimethylsiloxane copolymer, polydimethylsiloxane PEG-7 phosphate TEA salt, (tetrabutoxy)propyltrisiloxane, tetramethylhexanetetraphenyltetrasiloxane, tetramethyltetraphenyltrisiloxane, tocopheryloxypropyltrisiloxane, tridecyl alcohol polyether-9PG-amino-terminated polydimethylsiloxane, triethoxyoctylsilane, triethoxysilylethyl polydimethylsiloxane / polymethylsiloxane copolymer, triethoxysilylethyl polydimethylsiloxane, triethoxysilylethyl polydimethylsiloxane, triethoxysilylethyl polydimethylsiloxane, triethoxysilylethyl polydimethylsiloxane, triethoxysilylethyl polydimethylsiloxane, triethoxysiloxane Oxymethylsilylpropylcarbamoylethoxypropylbutyl polydimethylsiloxane, trifluoromethyl C1-4 alkyl polydimethylsiloxane, trifluoropropylcyclopentasiloxane, trifluoropropylcyclotetrasiloxane, trifluoropropyl polydimethylsiloxane, trifluoropropyl polydimethylsiloxane / PEG-10 crosslinked polymer, trifluoropropyl polydimethylsiloxane / trifluoropropyl divinyl polydimethylsiloxane crosslinked polymer, trifluoropropyl polydimethylsiloxane / vinyltrifluoropropyl polydimethylsiloxane / silsesquioxane crosslinked polymer, trifluoropropyl polydimethylsiloxane alcohol, trifluoropropyl dimethyl / trimethylsiloxysilicate, trifluoropropyl polymethylsiloxane, trimethoxyoctylsilane, trimethoxysilyl polydimethylsiloxane, trimethylpentaphenyltrisiloxaneTrimethylsiloxane amino-terminated polydimethylsiloxane, trimethylsiloxane oxyphenyl polydimethylsiloxane, trimethylsiloxane silicate, trimethylsiloxane silicate / polydimethylsiloxane crosslinked copolymer, trimethylsiloxane silicate / polydimethylsiloxane alcohol crosslinked polymer, trimethylsiloxane silyl carbamoyl amylopectin, trimethylsilyl hydrolyzed conchiolin PG-propyl methylsilanediol crosslinked polymer, trimethylsilyl hydrolyzed silk PG-propyl methylsilanediol crosslinked polymer, trimethylsilyl hydrolyzed wheat protein PG-propyl methylsilanediol crosslinked polymer, trimethylsilyl pullulan, trimethylsilane alcohol tris(methylsiloxane) glycolate, trimethylsiloxane... Methylsilane alcohol trisilylated lactate, trimethylsilane alcohol trisilylated salicylate, polytriphenyltrimethylsiloxane, trisiloxane, tris(tributoxysiloxy)methylsilane, undecene polydimethylsiloxane, vinyl polydimethylsiloxane, vinyl polydimethylsiloxane / lauryl polydimethylsiloxane crosspolymer, vinyl polydimethylsiloxane / polymethylsiloxane silsesquioxane crosspolymer, vinyl dimethyl / trimethylsiloxysilicate / stearyl polydimethylsiloxane crosspolymer, VP / dimethylaminoethyl acrylate / polyurethane / polyethylene glycol ester, zinc carboxydecyltrisiloxane and zinc polydimethylsiloxane PEG-8 succinate and mixtures thereof.

[0069] The silicone contained in the mixture according to the invention is more preferably polydimethylsiloxane, cyclomethicone, phenyltrimethylsiloxane, cyclohexylsiloxane, and cyclopentasiloxane. A detailed description of suitable volatile siloxane compounds can be found in Todd et al. in Cosm. Toil. 91, 27 (1976). waxes and stabilizers

[0070] In addition to the natural oils used, the formulation may also contain waxes, especially natural waxes such as candelilla wax, carnauba wax, Japanese wax, espartograss wax, cork wax, guaruma wax, rice bran oil wax, sugarcane wax, ouricury wax, lignite wax, beeswax, shellac wax, whale wax, lanolin, uropygial fat, (pure) ceresin, ceresin (paraffin), petroleum jelly, petroleum wax, and microcrystalline wax; chemically modified waxes (hard waxes) such as montan ester waxes, sasolwaxes, hydrogenated jojoba waxes; and synthetic waxes such as polyalkylene waxes and polyethylene glycol waxes.

[0071] Metal salts of fatty acids, such as stearates or ricinoleates of magnesium, aluminum and / or zinc, can be used as stabilizers. Main sunscreen agents

[0072] The main sunscreen agent in this invention is, for example, an organic substance (light-filtering substance) that is in a liquid or crystalline state at room temperature. It can absorb ultraviolet radiation and release the absorbed energy in the form of long-wave radiation, such as heat.

[0073] The formulations according to the invention advantageously contain at least one UV-A filter and / or at least one UV-B filter and / or a broad-spectrum filter and / or at least one inorganic pigment. The formulations according to the invention preferably contain at least one UV-B filter or a broad-spectrum filter, and more particularly contain at least one UV-A filter and at least one UV-B filter.

[0074] The UV filter materials used in this invention as cited below are preferred, but not limited to, these materials. Preferably, the UV filter materials used are selected from one, two, three, four, five, or more of the following:

[0075] Preferred UV filters include:

[0076] In a preferred embodiment, component (ii) forming the sunscreen filter represents a blend of UV-A and UV-B filters selected from high salicylates, octocrylene, bis-ethylhexyloxyphenol methoxyphenyl triazine, butyl methoxydibenzoylmethane, ethylhexyl salicylate, and mixtures thereof. Particularly preferred are mixtures of all these filters, commercially available under trademarks. (SYMRISE) is a commercial purchase, which is also the theme of WO 2020 088778A1.

[0077] Suitable pigments include oxides of titanium (TiO2), zinc (ZnO), iron (Fe2O3), zirconium (ZrO2), silicon (SiO2), manganese (e.g., MnO), aluminum (Al2O3), cerium (e.g., Ce2O3), and / or mixtures thereof.

[0078] In a further preferred embodiment, the formulation according to the invention comprises a total amount of sunscreen agent, i.e., in particular UV filter and / or inorganic pigment (UV filter pigment), such that the formulation according to the invention has a photoprotective factor greater than or equal to 5 and at most 50. Such formulations according to the invention are particularly suitable for protecting skin and hair. Secondary sunscreen

[0079] In addition to the main sunscreen groups mentioned above, secondary sunscreens with antioxidants can also be used. Antioxidant-based secondary sunscreens block the photochemical reaction chain that occurs when ultraviolet rays penetrate the skin. Typical examples include amino acids (e.g., glycine, histidine, tyrosine, tryptophan) and their derivatives, imidazoles (e.g., uric acid) and their derivatives, peptides such as D,L-carnosine, D-carnosine, L-carnosine and their derivatives (e.g., anserine), carotenoids, carotenoids (e.g., α-carotene, β-carotene, lycopene) and their derivatives, chlorogenic acid and its derivatives, lipoic acid and its derivatives (e.g., dihydrolipoic acid), aurora thioglycosides, propylthiouracil, and other thiols (e.g., thioredoxin, glutathione, cysteine, cystine, cystamine and its glycosyl, N-acetyl, methyl groups, etc.). Ethyl, propyl, pentyl, butyl, lauryl, palmitoyl, oleylenyl, α-linoleyl, cholesterol, and their glycerides) and their salts, dilaurate thiodipropionate, dioctadecyl thiodipropionate, thiodipropionic acid and its derivatives (esters, ethers, peptides, lipids, nucleotides, nucleosides, and salts), and sulfonylimine compounds with very low resistance doses (e.g., sulfonyl butyrate, sulfocysteine, sulfonyl butyrate, pentyl, hexa-, and hepta-thionine sulfonylimine), as well as (metal) chelating agents (e.g., α-hydroxy fatty acids, palmitic acid, phytic acid, lactoferrin), α-hydroxy acids Characteristic compounds (e.g., citric acid, lactic acid, malic acid), humic acid, bile acids, bile extracts, bilirubin, biliverdin, EDTA, EGTA and their derivatives, unsaturated fatty acids and their derivatives (e.g., linoleic acid, oleic acid), folic acid and its derivatives, ubiquinone and panthenol and their derivatives, vitamin C and its derivatives (e.g., ascorbate palmitate, ascorbate magnesium phosphate, ascorbate acetate), tocopherol and its derivatives (e.g., vitamin E acetate), vitamin A and its derivatives (vitamin A palmitate), as well as benzoic acid resins such as benzoyl benzoate, rutin and its derivatives, glycosylrutin, ferulic acid, and fenestrations. Sorbitol, carnosine, butylated hydroxytoluene, butylated hydroxyanisole, nordihydroguaiacol, lignan, trihydroxybutyrylbenzene, uric acid and its derivatives, mannose and its derivatives, superoxide dismutase, titanium dioxide (e.g., dispersions in ethanol), zinc and its derivatives (e.g., ZnO, ZnSO4), selenium and its derivatives (e.g., selenomethionine), stilbenes and their derivatives (e.g., stilbene oxide, trans-stilbene oxide), and derivatives of these active compounds suitable for the purposes of this invention (salts, esters, ethers, sugars, nucleotides, nucleosides, peptides, and lipids).

[0080] Advantageous inorganic secondary photoprotective pigments are finely dispersed metal oxides and metal salts, which are also mentioned in WO2005123101A1. In the finished cosmetic formulations according to the invention, the total amount of inorganic pigments, particularly hydrophobic inorganic micropigments, is advantageously 0.1 to 30% by weight, preferably 0.5 to 10.0% by weight, based on the total weight of the formulation in each case.

[0081] Also preferred are particulate UV filters or inorganic pigments, which may optionally be hydrophobic and may be oxides of, for example, titanium (TiO2), zinc (ZnO), iron (Fe2O3), zirconium (ZrO2), silicon (SiO2), manganese (e.g., MnO), aluminum (Al2O3), cerium (e.g., Ce2O3) and / or mixtures thereof. Biologics and antioxidants

[0082] Bioactive substances include, for example, tocopherol, tocopheryl acetate, tocopheryl palmitate, ascorbic acid, (deoxy)ribonucleic acid and its fragmentation products, beta-glucan, retinol, bisabolol, allantoin, phytanetriol, panthenol, AHA acid, amino acids, ceramides, pseudoceramides, essential oils, plant extracts such as plum extract, bambaranus extract, and vitamin complexes.

[0083] Antioxidants block the photochemical reaction chain that occurs when ultraviolet light penetrates the skin. Typical examples include amino acids (such as glycine, histidine, tyrosine, tryptophan) and their derivatives, imidazoles (such as uric acid) and their derivatives, peptides such as D,L-carnosine, D-carnosine, L-carnosine and their derivatives (such as anserine), carotenoids, carotene (carotene, lycopene) and their derivatives, chlorogenic acid and its derivatives, lipoic acid and its derivatives (such as dihydrolipoic acid), aurothioglucose, propylthiouracil and other thiols (such as thioredoxin, glutathione, cysteine, cystine, cystamine and their glycosyl, N-acetyl, methyl, ethyl, propyl, pentyl) Butyl and lauryl, palmitoyl, oleylene, α-linoleyl, cholesterol, and glyceryl esters) and their salts, dilaurate thiodipropionate, dioctadecyl thiodipropionate, thiodipropionic acid and its derivatives (esters, ethers, peptides, lipids, nucleotides, nucleosides, and salts), and sulfonyl imine compounds at very low resistance doses (pmol to mol / k) (e.g., sulfonyl butyrate, homocysteine, sulfonyl butyrate, pentyl, hexa-, and hepta-thionine sulfonyl imines), and (metal) chelating agents (e.g., hydroxy fatty acids, palmitic acid, phytic acid, lactoferrin). Hydroxy acids (e.g., citric acid, lactic acid, malic acid), humic acids, bile acids, bile extracts, bilirubin, biliverdin, EDTA, EGTA and their derivatives, unsaturated fatty acids and their derivatives (e.g., linolenic acid, linoleic acid, oleic acid), folic acid and its derivatives, ubiquinone and panthenol and their derivatives, vitamin C and its derivatives (e.g., ascorbate palmitate, ascorbate magnesium phosphate, ascorbate acetate), tocopherol and its derivatives (e.g., vitamin E acetate), vitamin A and its derivatives (vitamin A palmitate), as well as benzoic acid benzoate, rutin decaenoic acid and its derivatives. Glycosylrutin, ferulic acid, furfuryl sorbitol, carnosine, butylated hydroxytoluene, butylated hydroxyanisole, nordihydroguaiacol, nordihydroguaiacol, trihydroxybutyrophenone, uric acid and its derivatives, mannose and its derivatives, superoxide dismutase, zinc and its derivatives (e.g., ZnO, ZnSO4), selenium and its derivatives (e.g., methionine selenium), stilbenes and their derivatives (e.g., stilbene oxide, trans-stilbene oxide), and derivatives of these active compounds suitable for the purposes of this invention (salts, esters, ethers, sugars, nucleotides, nucleosides, peptides, and lipids). Active substances that regulate hair pigmentation

[0084] Preferred active ingredients for hair brightening are selected from the group comprising: kojic acid (5-hydroxy-2-hydroxymethyl-4-pyranone), kojic acid derivatives, preferably kojic acid dipalmitate, arbutin, ascorbic acid, ascorbic acid derivatives, preferably magnesium ascorbate phosphate, hydroquinone, hydroquinone derivatives, resorcinol, resorcinol derivatives, preferably 4-alkylresorcinol and 4-(1-phenylethyl)1,3-resorcinol (phenylethyl resorcinol), cyclohexyl carbamates (preferably WO3). One or more cyclohexyl carbamate esters disclosed in WO2010 / 122178 and WO2010 / 097480, sulfur-containing molecules, preferably glutathione or cysteine, α-hydroxy acids (preferably citric acid, lactic acid, malic acid), their salts and esters, N-acetyltyrosine and its derivatives, undecanoylphenylalanine, gluconic acid, chromone derivatives, preferably aloe-emodin, flavonoids, 1-aminoethylphosphonic acid, thiourea derivatives, ellagic acid, niacinamide, zinc salts, preferably zinc chloride or zinc gluconate, cypressin and its derivatives, triterpenoids, preferably crataegolic acid, sterols, preferably ergosterol, benzofuranones, preferably ligustrol, vinyl guaiacol, ethyl guaiacol, dionic acid acids), preferably octadecenoic acid and / or azelaic acid, inhibitors of nitrogen oxide synthesis, preferably L-nitroarginine and its derivatives, 2,7-dinitroindazole or thiocitrulline, metal chelating agents (preferably α-hydroxy fatty acids, phytic acid, humic acid, cholic acid, bile extracts, EDTA, EGTA and their derivatives), retinoids, soy milk and extracts, serine protease inhibitors or lipoic acid, or other synthetic or natural active ingredients for skin and hair brightening, the latter preferably used in the form of plant extracts, preferably bearberry extract, rice extract, papaya extract, turmeric extract, mulberry extract, jicama extract, cyperus extract, licorice root extract or components concentrated or isolated therefrom, preferably glycyrrhizin or glycyrrhizin chalcone M, jackfruit extract, sorrel and uncaria extracts, pine (pine tree) extracts, grape extracts or scutellaria derivatives isolated or concentrated therefrom, saxifrage extract, scutellaria extract (Scutellaria baicalensis) Extracts), grape extracts and / or microalgae extracts, especially *Tetracapterhosum* extract.

[0085] Beneficial active ingredients for skin and hair tanning in this regard include substrates or substrate analogs of tyrosinases, such as L-tyrosine, N-acetyltyrosine, L-DOPA, or L-dihydroxyphenylalanine; xanthine alkaloids, such as caffeine, theobromine, and theophylline and their derivatives; melanocortin precursor peptides, such as ACTH, α-MSH, their peptide analogs, and other substances that bind to melanocortin receptors; peptides; pyrimidine compounds; folic acid; and copper salts such as copper gluconate and chloride. Copper oxide or copper pyrrolidine, 1,3,4-oxadiazol-2-thiols such as 5-pyrazin-2-yl-1,3,4-oxadiazol-2-thiols, curcumin, zinc diglycinate (Zn(GIy)2), manganese(II) dicarbonate complexes (“pseudocat-alases”), as described, for example, in EP0584178, tetrasubstituted cyclohexene derivatives, such as those described in WO2005 / 032501, isoprene terpenes, such as WO The melanin derivatives described in 2005 / 102252 and WO2006 / 010661, such as Melasyn-100 and MelanZe, diacylglycerols, aliphatic or cyclic diols, psoralens, prostaglandins and their analogues, activators of adenylate cyclase and compounds that activate the conversion of hair melanosomes into keratinocytes, such as serine proteases or PAR-2 ​​receptor agonists, extracts of plants and parts of the genus Chrysanthemum, extracts of plants and parts of the genus Sanguisorba, walnut extract, urucum extract, rhubarb extract, microalgae extracts, especially Isochrysis galbana, trehalose, erythritol and dihydroxyacetone. Flavonoids that cause skin and hair staining or browning (such as quercetin, rhamnone, kaempferol, rutin, genistein, daidzein, apigenin and genistein, epicatechin, geraniol and geraniol, morin, quercetin, naringin, hesperidin, phlorizin, phlorizin) can also be used.

[0086] The amounts of the aforementioned examples of other active ingredients (one or more compounds) used to adjust skin and hair pigmentation in the products according to the invention are preferably 0.00001 to 30% by weight, more preferably 0.0001 to 20% by weight, and particularly preferably 0.001 to 5% by weight, based on the total amount of the formulation. Hair growth activators or inhibitors

[0087] The formulations and products according to the present invention may also contain one or more hair growth activators, i.e., formulations that stimulate hair growth. Hair growth activators preferably comprise pyrimidine derivatives, such as 2,4-diaminopyrimidine-3-oxide (Aminexil), 2,4-diamino-6-piperidinopyrimidine-3-oxide (Minoxidil) and their derivatives, 6-amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine and their derivatives, xanthine alkaloids, such as caffeine, theobromine and theophylline and their derivatives, quercetin and its derivatives, dihydroquercetin (tacutanein) and its derivatives, potassium channel openers, anti-androgen drugs, synthetic or natural 5-reductase inhibitors, nicotinic acid esters, such as nicotinic acid tocopheryl ester, benzyl nicotinate and C1-C6 alkyl nicotinate, proteins such as tripeptides Lys-Pro-Val, diphthylpren, hormones, finasteride, dutasteride, flutamide, bicalutamide, pregnane derivatives, progesterone and its derivatives, cyproterone acetate. Ketones, spironolactone and other diuretics, calcineurin inhibitors such as FK506 (tacrolimus, Fujimycin) and its derivatives, cyclosporine A and its derivatives, zinc and zinc salts, polyphenols, proanthocyanidins, phytosterols such as β-sitosterol, biotin, eugenol, (±)-β-citronellol, panthenol, glycogen, for example derived from mussels, microorganisms, algae, Extracts of plants and plant parts, such as those from the following genera: dandelion (Taraxacum or Taraxacum), ginseng, Vitex negundo, coffee, clematis, cocoa, Asarum heterotropoides, Cucurbita or Sophora japonica, saw palmetto, Sophora flavescens, African pine, millet, Cimicifuga foetida, soybean, clove, smoke tree, hibiscus, tea tree, Paraguayan tea, Isochrysis galanga, licorice, grape, apple, barley or hops, and / or rice or wheat hydrolysates.

[0088] Optionally, the formulations and products according to the present invention may further comprise one or more hair growth inhibitors (as described above), i.e., formulations that slow down or prevent hair growth. The hair growth inhibitors preferably comprise activators, activator derivatives or activator agonists, ornithine decarboxylase inhibitors, such as α-difluoromethylornithine, or pentacyclic triterpenoids such as ursolic acid, betulin, betulinic acid, oleanolic acid and its derivatives, 5α-reductase inhibitors, androgen receptor antagonists, S-adenosylmethionine decarboxylase inhibitors, γ-glutamyl transpeptidase inhibitors, glutamine transaminase inhibitors, serine protease inhibitors derived from soybean, extracts from microorganisms, algae, various microalgae, or plants and plant parts, such as those from the legume family, solanaceae family, grass family, asclepiadaceae family, or cucurbitaceae family, *Chloranthus*, *Hydrocotyle*, *Gnaphalium*, *Dourville*, *Glycine*, *Sanguisorba*, *Calendula*, *Hamamelis*, *Montana*, *Salix*, *St. John's wort*, or *Gymnema*. Skin care products

[0089] Typical examples of skin moisturizing and repairing agents include sodium lactate, urea and its derivatives, glycerin, propylene glycol, 1,2-pentanediol, 1,2-hexanediol and 1,2-octanediol, collagen, elastin or hyaluronic acid, adipate diesters, petrolatum, urocanic acid, lecithin, allantoin, panthenol, phytanetriol, lycopene, (pseudo)ceramides (preferably ceramide 2, hydroxypropyl bispalmitamide MEA, cetyloxypropylglyceromethoxypropylmyristamide, N-(1-hexadecyl)-4-hydroxy-L-proline (1-hexadecyl) ester, hydroxyethylpalmitoyloxyhydroxypropylpalmitamide), glycosphingolipids, cholesterol, phytosterols, chitosan, chondroitin sulfate, lanolin, lanolin esters, amino acids, vitamins Tocopherol E and its derivatives (preferably tocopherol, tocopheryl acetate), α-hydroxy acids (preferably citric acid, lactic acid, malic acid) and their derivatives, monosaccharides, disaccharides and oligosaccharides, preferably glucose, galactose, fructose, mannose, levulose and lactose, polysaccharides, such as β-glucan, especially 1,3-1,4-β-glucan from oats, α-hydroxy fatty acids, triterpenic acids, such as betulinic acid or ursolic acid, and algal extracts or their single active compounds, (vii) physiological cooling agents, preferably selected from the group including menthone glycerol acetal, menthyl lactate, preferably l-menthyl lactate, especially l-menthyl lactate, menthyl oxalate ethyl ester, substituted menthyl-3-carboxylic amides (e.g., menthyl-3-carboxylic acid N-acetamide, N... a -(L-menthanecarbonyl)glycine ethyl ester, 2-isopropyl-N-2,3-trimethylbutyramide, substituted cyclohexanecarboxylic acid amide, 3-menthoxypropane-1,2-diol, 2-hydroxyethyl menthyl carbonate, 2-hydroxypropyl menthyl carbonate, N-acetylglycine menthyl ester, isopreneol, hydroxycarboxylic acid menthyl esters (e.g., 3-hydroxybutyrate menthyl ester), succinate monomenthyl ester, glutaric acid monomenthyl ester, 2-mercaptocyclodecone, 2-pyrrolidine-5-ketocarboxylic acid menthyl ester, 2,3-dihydroxy-p-menthane, 3,3,5-trimethylcyclohexanone glycerol ketal, 3,6-di- and-trioxane 3-menthyl ester, methoxyacetic acid 3-menthyl ester and icilin, and physiological cooling agents and warming agents

[0090] Physiological cooling agents are liquids or solids, particularly crystalline substances. The sensation of cold is not triggered by a physical mechanism, but rather by the binding of the cooling agent to a physiologically activated cold receptor. This receptor is the cation channel TRPM8, a member of the TRP channel family. TRPM8 is located at the free nerve endings of afferent A and C fibers and is crucial for the sensation of cold. Physiological cooling agents, such as menthol and menthol compounds, are preferably selected from the substances shown in the table below (including their optical isomers and racemates):

[0091] Physiological thermogenic agents can be selected from the group including capsaicin, dihydrocapsaicin, nordihydrocapsaicin, high capsaicin, high dihydrocapsaicin, N-vanillylnonivamide, and chili extract. Antipruritic and anti-inflammatory agents

[0092] Suitable anti-inflammatory agents are selected from the following groups: (i) Corticosteroid anti-inflammatory substances, especially hydrocortisone, hydrocortisone derivatives such as hydrocortisone 17-butyrate, dexamethasone, dexamethasone phosphate, methylprednisolone or cortisone, (ii) Nonsteroidal anti-inflammatory drugs, especially oxoxacins such as piroxicam or tenoxacins, salicylates such as aspirin, disalcid, solprin or fendosal, acetic acid derivatives such as diclofenac, fenclofenac, indomethacin, sulindac, tolmetin or clindanac, fenamirates such as mefenamic acid, meclofenamic acid, flufenamic acid or niflufenic acid, propionic acid derivatives such as ibuprofen, methoxynaphthylpropionic acid or benzoxalofen, and pyrazoles such as phenylbutazone, oxyphenbutazone, febrazone or azaacetone. (iii) Natural or naturally occurring anti-inflammatory substances or substances that relieve redness and / or itching, especially extracts or fractions of chamomile, aloe vera, myrrh, madder, willow, willow grass, oats, calendula, arnica, St. John's wort, honeysuckle, rosemary, passionflower (Passiflora incarnata), witch hazel, ginger, or purple daisy, or single active compounds thereof. (iv) Histamine receptor antagonists, serine protease inhibitors (e.g., soybean extract), TRPV1 antagonists (e.g., 4-tert-butylcyclohexanol), NK1 antagonists (e.g., aprepitant, hydroxyphenylpropionamide benzoic acid), palmitoylethanolamine, and TRPV3 antagonists. Antimicrobial agents

[0093] A suitable antimicrobial agent is theoretically any substance capable of resisting Gram-positive bacteria, such as 4-hydroxybenzoic acid and its salts and esters, N-(4-chlorophenyl)-N′-(3,4-dichlorophenyl)urea, 4-chloro-3,5-dimethylphenol, 2,2′-methylenebis(6-bromo-4-chlorophenol), 3-methyl-4-(1-methylethyl)phenol, 2-benzyl-4-chlorophenol, 3-(4-chlorophenoxy)-1,2-propanediol, and 3-iodo-2-propyne. Butyl carbamate, chlorhexidine, 3,4,4′-trichlorocarbamate (TTC), antibacterial fragrance, thymol, thymol oil, eugenol, clove oil, menthol, peppermint oil, farnesol, phenoxyethanol, glyceryl monodecanoate, glyceryl monocaprylate, glyceryl monolaurate (GML), diglyceryl monodecanoate (DMC), 1,3-propanediol monocaprylate, 4-hydroxyacetophenone, N-alkyl amides of salicylic acid, such as n-octylsalicylate or n-decylsalicylate. Enzyme inhibitors

[0094] Suitable enzyme inhibitors are, for example, esterase inhibitors. These inhibitors are preferably trialkyl citrates, such as trimethyl citrate, tripropyl citrate, triisopropyl citrate, tributyl citrate, and, in particular, triethyl citrate (HydagenCAT). These substances inhibit enzyme activity, thereby reducing odor formation. Other suitable substances as esterase inhibitors are sterol sulfates or phosphates, such as lanosterol sulfate or phosphate, cholesterol sulfate or phosphate, campesterol sulfate or phosphate, stigmasterol sulfate or phosphate, and sitosterol sulfate or phosphate; dicarboxylic acids and their esters, such as glutaric acid, monoethyl glutarate, diethyl glutarate, adipic acid, monoethyl adipic acid, diethyl adipic acid, malonic acid, and diethyl malonate; hydroxycarboxylic acids and their esters, such as citric acid, malic acid, tartaric acid, or diethyl tartarate; and zinc glycinate. Odor absorbents and antiperspirants

[0095] Suitable odor absorbers are substances capable of absorbing and largely retaining odor-forming compounds. They lower the partial pressure of the components, thereby reducing their diffusion rate. It is important that the fragrance remains undamaged during this process. Odor absorbers have no effect on bacteria. They contain, for example, complex zinc salts of ricinoleic acid as a main component, or specific main odor-neutralizing fragrances known to those skilled in the art as "fragrance fixatives," such as extracts of rockrose or styrax, or some abietic acid derivatives. Odor masking agents are fragrances or aromatic oils that, in addition to their function as odor maskers, also impart their respective fragrance to deodorants. Aromatic oils that may be mentioned are, for example, mixtures of natural and synthetic fragrances. Natural fragrances are extracts of flowers, stems and leaves, fruits, peels, roots, wood, herbs and grasses, pine needles and twigs, as well as resins and balsams. Animal products, such as civet and castoreum, are also suitable. Typical synthetic aromatic compounds are esters, ethers, aldehydes, ketones, alcohols, and hydrocarbon products. Ester aromatic compounds include, for example, benzyl acetate, p-tert-butylcyclohexyl acetate, linalyl acetate, phenethyl acetate, linalyl benzoate, benzyl formate, allyl cyclohexylpropionate, styraxyl propionate, and benzyl salicylate. Ethers include, for example, benzyl ethyl ether; aldehydes include, for example, straight-chain alkanes containing 8 to 18 carbon atoms, citral, citronellol, citronelloloxyacetaldehyde, cyclamenaldehyde, hydroxycitronellol, lily of the valley aldehyde, and bourgeonal; ketones include, for example, ionone and methyl cedrol; alcohols include anethole, citronellol, eugenol, isoeugenol, geraniol, linalool, phenethyl alcohol, and terpineol; hydrocarbons mainly include terpenes and balsams. However, it is preferable to use mixtures of different aromatic compounds that together produce a pleasant fragrance. Essential oils with low volatility that are commonly used as aromatic components are also suitable as aromatic oils, such as sage oil, chamomile oil, clove oil, bee pollen oil, peppermint oil, cinnamon leaf oil, linden flower oil, juniper berry oil, vetiver oil, frankincense oil, galbanum oil, rockrose oil, and lavender oil.Bergamot oil, dihydromyrcenol, lily aldehyde, neolily aldehyde, citronellol, phenethyl alcohol, α-hexylcinnamaldehyde, geraniol, benzylacetone, cyclamate aldehyde, linalool, boisambrene forte, ambergris, indole, methyl dihydrojasmone, sandelice, lemon oil, citrus oil, orange oil, isopentoxyethyl acetate, cyclovertal, lavender oil, sage oil, β-damascone, bourbon geranium oil, cyclohexyl salicylate, VertofixCoeur, Iso-E-Super, Fixolide NP, evernyl, iraldein gamma, phenylacetic acid, geraniol acetate, benzyl acetate, rose ether, romilat, ethyl 2-ethylhexanoate, and 2-tert-butylcyclohexylethyl carbonate.

[0096] Suitable astringent and antiperspirant active ingredients are primarily salts of aluminum, zirconium, or zinc. These suitable antihydrotic active ingredients include, for example, aluminum chloride, aluminum hydrochloride, aluminum dihydrochloride, aluminum sesquihydrochloride, and their complexes, such as complexes with 1,2-propanediol; aluminum allantoinate; aluminum tartrate chloride; aluminum zirconium trihydrochloride, aluminum zirconium tetrahydrochloride, aluminum zirconium pentahydrochloride, and their complexes, such as complexes with amino acids like glycine. Film-forming agents and anti-dandruff agents

[0097] Standard film-forming agents include, for example, chitosan, microcrystalline chitosan, quaternary ammonium chitosan, polyvinylpyrrolidone, vinylpyrrolidone / vinyl acetate copolymer, acrylic polymers, quaternary cellulose derivatives, collagen, hyaluronic acid and its salts and similar compounds.

[0098] A suitable anti-dandruff agent is Pirocton Olamin (1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-(1H)-pyridone monoethanolamine salt). (clomibazole) (4-Acetyl-1-{4-[2-(2,4-dichlorophenyl)r-2-(1H-imidazol-1-ylmethyl)-1,3-dioxylan-c-4-ylmethoxyphenyl}-piperazine, ketoconazole, neoconazole, selenium disulfide, colloidal sulfur, sulfur-modified polyethylene glycol dehydrated sorbitan monooleate, sulfur-modified ricinoleic acid polyethoxylate, sulfur tar fraction, salicylic acid (or conjugated hexachlorophenol), undecanoic acid, sodium monoethanolamide sulfosuccinate. (Protein / Undecenoic Acid Concentrate), Zinc Pyrithione, Aluminum Pyrithione, and Magnesium Pyrithione / Dipyrithione Magnesium Sulfate. Carrier and water-soluble agent

[0099] Preferred cosmetic carrier materials are solid or liquid (including high-viscosity substances) at 25°C and 1013 mbar, such as glycerol, 1,2-propanediol, 1,2-butanediol, 1,3-propanediol, 1,3-butanediol, ethanol, water, and mixtures of two or more of the said liquid carrier materials with water. Optionally, these formulations of the present invention can be prepared using preservatives or solubilizers. Other preferred liquid carrier materials that can be used as components of the formulations of the present invention are selected from the group consisting of oils, such as vegetable oils, neutral oils, and mineral oils.

[0100] Preferred solid carrier substances that can be used as components of the formulations of the present invention are hydrocolloids, such as starch, degraded starch, chemically or physically modified starch, dextrin, (powdered) maltodextrin (preferably with a glucose value of 5 to 25, more preferably 10 to 20), lactose, silicon dioxide, glucose, modified cellulose, gum arabic, gum agar, guanosine gum, carrageenan, pullulan, gelatin, xanthan gum, gellan gum, guar gum, carob powder, alginate, agar, pectin and inulin, as well as mixtures of two or more of these solid substances, especially maltodextrin (preferably with a glucose value of 15 to 20), lactose, silicon dioxide and / or glucose.

[0101] In addition, water-soluble agents, such as ethanol, isopropanol, or polyols, can be used to improve flowability. Suitable polyols preferably contain 2 to 15 carbon atoms and at least two hydroxyl groups. Such polyols may contain other functional groups, more specifically amino groups, or may be nitrogen-modified. Typical examples include: ·glycerin; Alkanediols, such as ethylene glycol, diethylene glycol, propylene glycol, butanediol, hexanediol, and polyethylene glycol with an average molecular weight of 100 to 1000 Daltons; • Polyglycerol technical blends with a degree of self-condensation of 1.5 to 10, such as polyglycerol technical grade blends with a diglycerol content of 40 to 50% by weight; • Hydroxymethyl compounds, particularly, for example, trimethylolethane, trimethylolpropane, trimethylolbutane, pentaerythritol and dipentaerythritol; • Lower alkyl glycosides, especially those alkyl glycosides containing 1 to 8 carbon atoms in the alkyl group, such as methyl glycosides and butyl glycosides; • Sugar alcohols containing 5 to 12 carbon atoms, such as sorbitol or mannitol; • Sugars containing 5 to 12 carbon atoms, such as glucose or sucrose; Amino sugars, such as glucosamine; Diolamines, such as diethanolamine or 2-aminopropane-1,3-diol Preservatives and / or product protectants

[0102] Suitable preservatives are listed in Annexes 6A and 6B of the Cosmetics Directive and are selected from the group including benzoic acid and p-hydroxybenzoic acid, their esters and salts, benzyl benzoate, propionic acid and its salts, salicylic acid and its salts, 2,4-hexadienoic acid (sorbic acid) and its salts, levulinic acid and its salts, anisic acid and its salts, perillic acid and its salts, cinnamic acid and its salts, formaldehyde and paraformaldehyde, 4-hydroxybenzaldehyde, o-, m- and p-anisaldehyde, cinnamaldehyde, cinnamyl alcohol, 2-hydroxydiphenyl ether and its salts, 2-zinc-thiopyridine N-oxide, inorganic sulfites and bisulfites, sodium iodate, chlorobutanol, 4-ethylmercuric-(II)5- Amino-1,3-bis(2-hydroxybenzoic acid), its salts and esters, anhydroacetic acid, formic acid, 1,6-bis(4-amidinyl-2-bromophenoxy)-n-hexane and its salts, sodium salt of ethylmercury(II)-thiosalicylic acid, phenylmercury and its salts, 10-undecenoic acid and its salts, 5-amino-1,3-bis(2-ethylhexyl)-5-methyl-hexahydropyridine, 5-bromo-5-nitro-1,3-dioxane, 2-bromo-2-nitro-1,3-propanediol, 2,4-dichlorobenzyl alcohol, N-(4-chlorophenyl)-N'-(3,4-dichlorophenyl)urea, 4-chloro-m-cresol, 4-chloro 3,5-Dimethylphenol, 1,1'-Methylene-di(3-(1-hydroxymethyl-2,4-dioximidazolidine-5-yl)urea), poly-(hexamethylene biguanide) hydrochloride, (benzyloxymethoxy)-methanol, hexamethylenetetramine, 1-(3-chloroallyl)-3,5,7-triaza-1-azamonoadamantane chloride, 1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethyl-2-butanone, 1,3-di(hydroxymethyl)-5,5-dimethyl-2,4-imidazolinide, 1,2-di... Bromo-2,4-dicyanbutane, 2,2'-methylene-di(6-bromo-4-chlorophenol), bromochlorobenzene, 5-chloro-2-methyl-3(2H)-isothiazolinone and 2-methyl-3(2H)-isothiazolinone mixed with magnesium chloride and magnesium nitrate, 2-octyl-2H-isothiazo-3-one, 1,2-benzisothiazol-3(2H)-one, 2-benzyl-4-chlorophenol, 3-(4-chlorophenoxy)-1,2-propanediol (Chlorphenesin), 2-chloroacetamide, chlorhexidine, chlorhexidine acetate, chlorhexidine gluconate, chlorhexidine hydrochloride, N-alkyl(C 12 -C 22 Trimethyl-ammonium bromide and N-alkyl (C 12 -C 22Trimethylammonium chloride, 4,4-dimethyl-1,3-oxazolidine, N-hydroxymethyl-N-(1,3-di(hydroxymethyl)-2,5-dioxoimidazoline-4-yl)-N'-hydroxymethylurea, 1,6-di(4-formamidinyl-phenoxy)-n-hexane and its salts, glutaraldehyde, 5-ethyl-1-aza-3,7-dioxabicyclo(3.3.0)octane, 3-(4-chlorophenoxy)-1,2-propanediol, hyamines, alkyl-(C8-C 18 )-Dimethyl-benzylammonium chloride, alkyl-(C8-C 18 )-Dimethyl-benzylammonium bromide, alkyl-(C8-C 18Dimethyl-benzylammonium saccharide, benzyl hemiacetal, 3-iodo-2-propynyl butylcarbamate, sodium hydroxymethyl-aminoacetate or sodium hydroxymethyl-aminoacetate, imidazolidinyl urea, diazolidinyl urea, sodium hydroxymethylglycinate, DMDM ​​hydantoin, tyrosinone, (ethylenedioxy)diethanol, 2-bromo-2-(bromomethyl)pentanilonitrile, N-(3-aminopropyl)-N-dodecylpropane-1,3-diamine, α,α',α“-trimethyl-1,3,5-triazine-1,3,5(2H,4H,6H)-triethanol, pyridine-2-thiol-1-oxide, Sodium salt, tetrahydro-1,3,4,6-tetra(hydroxymethyl)imidazo[4,5-d]imidazo-2,5(1H,3H)-dione, 1,3-bis(hydroxymethyl)-1-(1,3,4-tris(hydroxy-methyl)-2,5-dioxoimidazolidin-4-yl)urea (bis(imidazolidinyl)urea), 1,3-bis(hydroxy-methyl)-5,5-dimethylimidazolidin-2,4-dione, 3-acetyl-2-hydroxy-6-methyl-4H-pyran-4-one, hexadecylpyridine chloride, octanoyl hydroxamic acid, sorbitol isohydroxamic acid (acid) and mixtures thereof, 1,3-propanediol, methylpropanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, 1,2-decanediol, 1,5-pentanediol, 1,6-hexanediol, 1,8-octanediol, 1,2-decanediol, ethylhexylglycerol, hexoxy-prop-1,2-diol, heptaoxy-prop-1,2-diol, octoxy-prop-1,2-diol, 3-phenoxy-prop-1,2-diol, 3-benzyloxy-prop-1,2-diol, 3-phenethoxy-prop-1,2-diol, 3-phenylpropoxy-prop-1,2-diol, 3-methylbenzyloxy-prop-1,2-diol, sorbitan caprylate, chlorfenapyridine, Oc Topirox (1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone, 2-aminoethanol), chitosan, farnesol, 2-butyloctanoic acid, 2-benzylhept-1-ol, glyceryl monolaurate, bis(2-pyridinylthio)zinc 1,1′-dioxide, N,N′-(decylidene 1,10-dipyridin-1-yl-4-ylidene)-dioctane-1-amine dihydrochloride (otinidin dihydrochloride), thymol, eugenol, benzyl alcohol, 2-phenylethanol, 3-phenylpropanol, 2-phenoxyethanol, 1-phenoxy-prop-2-ol, 3-phenoxypropanol, benzyl methoxymethanol, 4-hydroxyacetophenone and mixtures thereof. aromatic oils

[0103] Appropriate aromatic oils are mixtures of natural and synthetic fragrances. Natural fragrances include extracts of flowers (lily, lavender, rose, jasmine, orange blossom, ylang-ylang), stems and leaves (geranium, patchouli, bitter orange), fruits (fennel, coriander, cilantro, juniper), peels (bergamot, lemon, orange), roots (nutmeg, angelica, celery, cardamom, costus root, iris, calamus), woods (pine, sandalwood, guaiac, cedar, mahogany), herbs and grasses (tarragon, lemongrass, sage, thyme), conifers and branches (spruce, fir, pine, dwarf pine), resins and balsams (galbanum, elemi, benzoin, myrrh, frankincense, opoponax). Animal ingredients, such as civet and castoreum, may also be used. spices Suitable spices include:

[0104] Aliphatic esters include 1-phenyl-2-methyl-2-propyl acetate, 2-methyl butyl butyrate, aldron (4-[(3,3-dimethylbicyclo[2.2.1]hept-2-yl)methyl]-2-methylcyclohexanone), allyl 2-cyclohexyloxyglycolate, allyl 2-pentoxyglycolate, allyl 3-cyclohexylpropionate, allyl hexanoate, amarocite (1,1-dimethoxy-2,2,5-trimethyl-4-hexene), ambral (dodecylhydro-3,8,8,11a-tetramethyl-5H-3.5a-epoxynaphthalene[2.1-c]oxaheptaene), ambretolide (9-hexadecene-16-lactone), and ambrinol. S(1,2,3,4,4a,5,6,7-octahydro-2,6,6-trimethyl-2-naphthylmethanol), ambrinolepoxide, Ambrocenide (4aR,5R,7aS,9R)-octahydro-2,2,5,8,8,9a-hexamethyl-4h-4a,9-methylene-otope(5,6-d)-1,3-dioxazole), Ambroxide (3a,6,6,9a-tetramethyl-dodecanonaphtho[2,1-b]-furan), amyl formate, Aureli one (7-cyclohexadecen-1-one and 8-cyclohexadecen-1-one), Boronal [2-methyl-4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-butenal], Brahmanol [2-methyl-4-(2,2,3-trimethyl-3-cyclopentenyl)-butanol], Buccoxime (1,5-dimethylbicyclo[3.2.1]octane-8-one oxime), butyl acetate, Cantryl (2,2,3-trimethyl-3-cyclopentenyl-1-acetonitrile), Cassix 150 (4-methoxy-2-methyl-2-butyritin), Chrysantheme [1-(2,4-dimethyl-3-cyclohexen-1-yl)-2,2-dimethyl-1-propanone], cis-3-hexenyl acetate, citronellol butyrate, citronellol tegmentol (3,7-dimethyl-6-octenyl-2-methylcrotonate), citronitrile (3-methyl-5-phenyl-2-pentanilide), Citrowanil b (α-vinyl-α-methylphenylpropionitrile), Claritone (2,4,7-Tetramethyl-6-octen-3-one), Corps racinevs [2-(3-phenylpropyl)pyridine], coumarone (1-(2-benzofuranyl)-ethyl ketone), Cyclogalbanate (allyl cyclohexyloxyacetate), Cyclohexylmagnol (α-methylcyclohexylpropanol), Datilate (1-cyclohexylethyl crotonate), ethyl-2-methylbutyrate, ethyl isobutyrate, ethyl isovalerate, ethyl tricyclo-[5.2.1,02,6]dec-2-alkylcarboxylate, farenal (2,6,10-trimethyl-9-undecenal), filbertone (5-methyl-2-hepten-4-one) Fleursandol (4-(3a,4,5,6,7,7a-hexahydro-4,7-methylene-1H-inden-6-yl)-3-methyl-3-buten-2-ol), Florazon (4-ethyl-α,α-dimethylphenylpropanal), Floropal (2,4,6-trimethyl-4-phenyl-1,3-dioxane), Fragolane [(2,4-dimethyl-[1,3]dioxacyclopentan-2-yl)ethyl acetate], Frutinat (1,3-dimethylbutyl butyrate), γ-decanoic acid, Geranyl acetate, Geranyl butyrate, Geranyl tetlinate (trans-3,7-dimethyl-2,6-octadienyl-2-methylcrotonate), Globanone [(11 / 12)-pentadene-15-lactone], Globanone (8-cyclohexadecene-1-one), hexyl butyrate, Hydrocitronitrile (β-methylphenylpentanol), Indianol (4-[3a,4,5,6,7,7a-hexahydro-4,7-methylene-1h-indene-5(6)-yl]-3-methyl-3-buten-2-ol), Indoflor (4,4a,5,9b-tetrahydroindo[1,2-d]m-dioxin), Irisnitrile (2-nonenonitrile), isoamyl acetate, isoamyl isovalerate, Isod amascon [1-(2,4,4-trimethyl-2-cyclohexen-1-yl)-2-buten-1-yl], Isomuscon (cyclohexadecanone), Jacinthaflor (2-methyl-4-phenyl-1,3-dioxolane), Ketamber (dodecylhydro-3,8,8,11a-tetramethyl-5h-3,5a-epoxynaphtho[2,1-c]oxacon), Lactojasmon (4-hexyl-4-methylbutyrolactone), Leguminal (propanal-methyl-cis-3-hexenyl-acetal), Macrolide (oxacyclohexadecanone-2-one), Madranol (a mixture of different hexahydromethyl ionones), Magnolan (2,4-Dimethyl-5,6-indeno-1,3-dioxane), Majantol [2,2-dimethyl-3-(3-methylphenyl)-propanol], Mandaril (3,12-tridecadienoic acid), menthyl acetate, methyl butyrate, methyl dihydrojasmonic acid, methyl isobutyrate, Mintonat (3,3,5-trimethylcyclohexyl acetate), Mugetanol [1-(4-isopropylcyclohexyl)-ethanol], Nerolione [1-(3-methyl-2- [Benzofuranyl]-ethyl ketone, octyl acetate, Ozonil (2-tridecenoyl nitrile), Palisandal (1,1-dimethoxycyclododecane), Palisandin (cyclododecyl methyl ether), Parmanyl [3-(cis-3-hexenoxy)propionitrile], Passifloran (3-acetylthiohexyl acetate), Peacholide (cis- and trans-3-methyl-γ-decyl lactone), Prenyl salicylate, Profarnesal (2,6,10-trimethyl-5,9-undecanedienal), Projasmon p (2-heptylcyclopentanone), Pyroprunate (butyric acid dicyclopenten-2-yl ester), Rholiate (ethyl-2,3,6-trimethylcyclohexyl carbonate), Rosaphene (2-methyl-5-phenylpentan-1-ol), rose oxide, sandel 80 (trans-3-isobornylcyclohexanol), Sandranol (2-ethyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-ol), Symrose (4-isopentylcyclohexanol), Symroxane (4-(3-methylbutyl)-cyclohexanol(z)), Tabanone [4-(2-butenylidene)-3,4,5-trimethyl-2-cyclohexen-1-one], terpineol-4, Timberol (2,2,6-trimethyl-α-propylcyclohexylpropanol), Tolylacetataldeyde dpara (4-methylphenylacetaldehyde), tricyclodecenylpropionate, Tropicol (2-mercapto-2-methyl-pentan-1-ol), Vertosine [2-(2,4-(or 3,5)-dimethyl-3-cyclohexen-1-yl)-methylene-amino-benzoate methyl ester], Vertral (octahydro-4,7-methylene-1H-indenealdehyde), Vetikolacetate (1,3-dimethyl-3-phenylbutylacetic acid ester), vetival (4-cyclohexyl-4-methylpentan-2-one), Ysamber k (spirocyclohexane-1',1',5',5'-tetramethyl-[1,3-dioxolane-2,8'-(5'H)-[2H-2,4a]-methylnaphthalene].

[0105] Aliphatic aldehydes and their acetals, such as hexanal, heptanal, octanal, nonanal, decanal, undecanoal, dodecanal, tridecanal, 2-methyloctanal, 2-methylnonanal, (E)-2-hexenal, (Z)-4-heptenal, 2,6-dimethyl-5-heptenal, 10-undecenal, (E)-4-decenal, 2-dodecenal, 2,6,10-trimethyl-9-undecenal, 2,6,10-trimethyl-5,9-undecadienal, heptanal diethyl acetal, 1,1-dimethoxy-2,2,5-trimethyl-4-hexene, citronelloloxyacetaldehyde, 1-(1-methoxy-propoxy)-(E / Z)-3-hexene;

[0106] Aliphatic ketones and their oximes, such as 2-heptanone, 2-octanone, 3-octanone, 2-nonanone, 5-methyl-3-heptanone, 5-methyl-3-heptanone oxime, 2,4,4,7-tetramethyl-6-octen-3-one, and 6-methyl-5-hepten-2-one;

[0107] Aliphatic sulfur-containing compounds, such as 3-methylthiohexanol, 3-methylthiohexyl acetate, 3-mercaptohexanol, 3-mercaptohexyl acetate, 3-mercaptohexyl butyrate, 3-acetylthiohexyl acetate, and 1-menthol-8-thiol.

[0108] Aliphatic nitrile, such as 2-nonenoic acid nitrile, 2-undecenoic acid nitrile, 2-tetratecenoic acid nitrile, 3,12-tetratecadienoic acid nitrile, 3,7-dimethyl-2,6-octadienoic acid nitrile, and 3,7-dimethyl-6-octenic acid nitrile.

[0109] Aromatic aliphatic alcohols, such as benzyl alcohol, 1-phenylethanol, 2-phenylethanol, 3-phenylpropanol, 2-phenylpropanol, 2-phenoxyethanol, 2,2-dimethyl-3-phenylpropanol, 2,2-dimethyl-3-(3-methylphenyl)propanol, 1,1-dimethyl-2-phenylethanol, 1,1-dimethyl-3-phenylpropanol, 1-ethyl-1-methyl-3-phenylpropanol, 2-methyl-5-phenylpentanol, 3-methyl-5-phenylpentanol, 3-phenyl-2-propen-1-ol, 4-methoxybenzyl alcohol, and 1-(4-isopropylphenyl)ethanol;

[0110] Aryl ethers, such as 2-phenylethyl methyl ether, 2-phenylethyl isopentyl ether, 2-phenylethyl-1-ethoxyethyl ether, phenylacetaldehyde dimethyl acetal, phenylacetaldehyde diethyl acetal, hydratropaaldehyde dimethylacetal, phenylacetaldehyde glycerol acetal, 2,4,6-trimethyl-4-phenyl-1,3-dioxane, 4,4a,5,9b-tetrahydroindene-[1,2-d]-m-dioxane, 4,4a,5,9b-tetrahydro-2,4-dimethylindene[1,2-d]-m-dioxane;

[0111] Aromatic and aliphatic aldehydes, such as: benzaldehyde, phenylacetaldehyde, 3-phenylpropanal, Hydratropaaldehyd, 4-methylbenzaldehyde, 4-methylphenylacetaldehyde, 3-(4-ethylphenyl)-2,2-dimethylpropanal, 2-methyl-3-(4-isopropylphenyl)propanal, 2-methyl-3-(4-isobutylphenyl)propanal, 2-methyl-3-(4-isopropylphenyl)propanal, 3-(4-tert-butylphenyl)propanal. α-Butylcinnamaldehyde, α-pentylcinnamaldehyde, α-hexylcinnamaldehyde, 3-methyl-5-phenylpentanal, 4-methoxybenzaldehyde, 4-hydroxy-3-methoxybenzaldehyde, 4-hydroxy-3-ethoxybenzaldehyde, 3,4-methylenedioxybenzaldehyde, 3,4-dimethoxybenzaldehyde, 2-methyl-3-(4-methoxyphenyl)propanal, 2-methyl-3-(4-methylenedioxyphenyl)propanal;

[0112] Aromatic and arylita-ketones, such as acetophenone, 4-methylacetophenone, 4-methoxyacetophenone, 4-tert-butyl-2,6-dimethylacetophenone, 4-phenyl-2-butanone, 4-(4-hydroxyphenyl)-2-butanone, 1-(2-naphthyl)acetone, 2-benzofuran acetone, 3-methyl-2-benzofuranyl)acetone, benzophenone, 1,1,2,3,6-hexamethyl-5-indanylmethyl ketone, 6-tert-butyl-1,1-dimethyl-4-indanylmethyl ketone, 1-[2,3-dihydro-1,1,2,6-tetramethyl-3-(1-methylethyl)-1H-5-indanyl]acetone; 5′,6',7',8′-tetrahydro-3′,5',5′,6',8′,8′-hexamethyl-2-naphthyl ketone;

[0113] Aromatic and aryl carboxylic acids and their esters, such as benzoic acid, phenylacetic acid, methyl benzoate, ethyl benzoate, hexyl benzoate, benzyl benzoate, methyl phenyl acetate, ethyl phenyl acetate, geranyl phenyl acetate, phenylethyl phenylacetate, methyl cinnamate, ethyl cinnamate, benzyl cinnamate, phenylethyl cinnamate; cinnamate, allyl phenoxyacetate, methyl salicylate, hexyl salicylate, cyclohexyl salicylate, cis-3-hexenyl salicylate, benzyl salicylate, phenylethyl salicylate, methyl 2,4-dihydroxy-3,6-dimethylbenzoate, ethyl 3-phenylglycidate, ethyl 3-methyl-3-phenylglycidate;

[0114] Noncyclic terpene alcohols, such as citronellol, geraniol, nerol, linalool, lavadulol, nerolidol, farnesol, tetrahydrolinalol, tetrahydrogeraniol, 2,6-dimethyl-7-octen-2-ol, 2,6-dimethyloct-2-ol, 2-methyl-6-methylene-7-octen-2-ol, 2,6-dimethyl-5,7-octadien-2-ol, 2,6-dimethyl-3,5-octadien-2-ol, 3,7-dimethyl-4,6-octadien-3-ol, 3,7-dimethyl-1,5,7-octtrien-3-ol, 2,6-dimethyl-2,5,7-octtrien-1-ol, and their formate, acetate, propionate, isobutyrate, butyrate, isovalerate, valerate, hexanoate, crotonate, tiglinate, and 3-methyl-2-butenoate;

[0115] Noncyclic terpene aldehydes and ketones, such as geranialdehyde, neraldehyde, citronellol, 7-hydroxy-3,7-dimethyloctanal, 7-methoxy-3,7-dimethyloctanal, 2,6,10-trimethyl-9-undecenal, geraniol acetone; and dimethyl and diethyl acetals of geranialdehyde, neraldehyde, and 7-hydroxy-3,7-dimethyloctanal; cyclic terpene alcohols, such as menthol; isopreneol; α-terpineol; terpinenol-4; menthol-8-ol; menthol-1-ol; menthol-7-ol; borneol; isoborneol; linalool oxide; noberol; cedrol; ambroxol; vetiverol; guaiacol; and their formate, acetate, propionate, isobutyrate, butyrate, isovalerate, valerate, hexanoate, crotonate, tiglinates, and 3-methyl-2-butenoate;

[0116] Cyclic terpenoid aldehydes and ketones, such as menthone, isomenthone, 8-mercaptomenthane-3-one, carvone, camphor, frankincense, α-ionone, β-ionone, α-n-methylionone, β-n-methylionone; α-isomethylionone, β-isomethylionone, α-irisone, α-damasone, β-damasone, β-damaseneone, δ-damasone, γ-damasone, 1-(2,4,4-trimethyl-2-cyclohexane) (en-1-yl)-2-buten-1-one, 1,3,4,6,7,8a-hexahydro-1,1,5,5-tetramethyl-2H-2,4a-methylenenaphthylamine-8(5H)-one, 2-methyl-4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2-butenal, nocacolone; dihydronocacolone; 4,6,8-mega-stigmastrien-3-one; α-sweet orange aldehyde; β-sweet orange aldehyde; acetylated cedar oil (methyl cedarone);

[0117] Cyclic alcohols, such as: 4-tert-butylcyclohexanol, 3,3,5-trimethyl-cyclohexanol, 3-isocampylcyclohexanol, 2,6,9-trimethyl-(Z2,Z5,E9)-cyclododecanetrien-1-ol, 2-isobutyl-4-methyltetrahydro-2H-pyran-4-ol;

[0118] Cycloaliphatic alcohols, such as α-3,3-trimethylcyclohexylmethanol, 1-(4-isopropylcyclohexyl)ethanol, 2-methyl-4-(2,2,3-trimethyl-3-cyclopent-1-yl)butanol, 2-methyl-4-(2,2,3-trimethyl-3-cyclopent-1-yl)-2-buten-1-ol, 2-ethyl-4-(2,2,3-trimethyl-3-cyclopent-1-yl)-2-buten-1-ol; 3-methyl-5- (2,2,3-Trimethyl-3-cyclopentan-1-yl)-pentan-2-ol, 3-methyl-5-(2,2,3-trimethyl-3-cyclopentan-1-yl)-4-penten-2-ol, 3,3-dimethyl-5-(2,2,3-trimethyl-3-cyclopentan-1-yl)-4-penten-2-ol, 1-(2,2,6-trimethylcyclohexyl)pentan-3-ol, 1-(2,2,6-trimethylcyclohexyl)hex-3-ol;

[0119] Cyclic ethers and cyclic aliphatic ethers, such as: eucalyptol, methyl cedarwood ether, cyclododecyl methyl ether, 1,1-dimethoxycyclododecane, (ethoxymethoxy)cyclododecane, α-epoxycedarwoodene, 3a,6,6,9a-tetramethyldodecanophen[2,1-b]furan, 3a-ethyl-6,6,9a-trimethyldodecanophen[2,1-b]furan, 1,5,9-trimethyl-13-oxabicyclo[10.1.0]-tetrazyl-4,8-diene, rose ether, 2-(2,4-dimethyl-3-cyclohexen-1-yl)-5-methyl-5-(1-methylpropyl)-1,3-dioxacyclohexane;

[0120] Cyclic ketones and macrocyclic ketones, such as: 4-tert-butylcyclohexanone, 2,2,5-trimethyl-5-pentylcyclopentanone, 2-heptylcyclopentanone, 2-pentylcyclopentanone, 2-hydroxy-3-methyl-2-cyclopenten-1-one, 3-methyl-cis-2-penten-1-yl-2-cyclopenten-1-one, 3-methyl-2-pentyl-2-cyclopenten-1-one, 3-methyl-4-cyclopentadecenone, 3-Methyl-5-cyclopentadecanone, 3-methylcyclopentadecanone, 4-(1-ethoxyvinyl)-3,3,5,5-tetramethylcyclohexanone, 4-tert-amylcyclohexanone, 5-cyclohexadecene-1-one, 6,7-dihydro-1,1,2,3,3-pentamethyl-4(5H)-indanone, 8-cyclohexadecene-1-one, 9-cycloheptadecene-1-one, cyclopentadecanone, cyclohexadecenecanone;

[0121] Cycloallic aldehydes, such as 2,4-dimethyl-3-cyclohexenecarboxaldehyde, 2-methyl-4-(2,2,6-trimethyl-cyclohexen-1-yl)-2-butenaldehyde, 4-(4-hydroxy-4-methylpentyl)-3-cyclohexenecarboxaldehyde, and 4-(4-methyl-3-penten-1-yl)-3-cyclohexenecarboxaldehyde;

[0122] Cyclic ketones, such as 1-(3,3-dimethylcyclohexyl)-4-penten-1-one, 2,2-dimethyl-1-(2,4-dimethyl-3-cyclohexen-1-yl)-1-propanone, 1-(5,5-dimethyl-1-cyclohexen-1-yl)-4-penten-1-one, 2,3,8,8-tetramethyl-1,2,3,4,5,6,7,8-octahydro-2-naphthylmethyl ketone, methyl-2,6,10-trimethyl-2,5,9-cyclododecanetrienone, and tert-butyl-(2,4-dimethyl-3-cyclohexen-1-yl)one;

[0123] Aliphatic carboxylic acid esters, such as (E) and (Z)-3-hexenic acid esters, ethyl acetoacetate, isoamyl acetate, hexyl acetate, 3,5,5-trimethyl-hexyl acetate, 3-methyl-2-butenyl acetate, (E)-2-hexenyl acetate, (E) and (Z)-3-hexenyl acetate, octyl acetate, 3-octyl acetate, 1-octen-3-acetate, ethyl butyrate, butyl butyrate, isoamyl butyrate, hexyl butyrate. Isobutyric acid (E) and (Z)-3-hexenyl ester, hexyl crotonate, ethyl isovalerate, ethyl 2-methylvalerate, ethyl hexanoate, allyl hexanoate, ethyl heptaate, allyl heptaate, ethyl octanoate, (E,Z)-2,4-decadienoic acid ethyl ester, methyl 2-octenate, methyl 2-nonenoate, allyl 2-isopentyloxyacetate, methyl 3,7-dimethyl-2,6-octadienoate; 4-methyl-2-pentyl crotonate;

[0124] Esters of cycloalcohols, such as 2-tert-butylcyclohexyl acetate, 4-tert-butylcyclohexyl acetate, 2-tert-pentylcyclohexyl acetate, 4-tert-pentylcyclohexyl acetate, 3,3,5-trimethylcyclohexyl acetate, decahydro-2-naphthyl acetate, 2-cyclopentyl cyclopentylcrotonate, 3-pentyl-tetrahydro-2H-pyran-4 ester of acetate, and decahydro-2,5,5,8a-tetramethyl-2-naphthyl acetate. 4,7-Methylene-3a,4,5,6,7,7a-hexahydro-5- or -6-indanate, 4,7-Methylene-3a,4,5,6,7,7a-hexahydro-5- or -6-indanate, 4,7-Methylene-3a,4,5,6,7,7a-hexahydro-5- or -6-indanate, 4,7-Methyleneoctahydro-5- or -6-indanate,

[0125] Esters of alicyclic alcohols, such as 1-cyclohexylethyl crotonate;

[0126] Cycloaliphatic carboxylic acid esters, such as allyl 3-cyclohexylpropionate, allyl cyclohexyloxyacetate, methyl cis and trans-dihydrojasmonic acid, methyl cis and trans-jasmonic acid, methyl 2-hexyl-3-oxocyclopentanecarboxylate, ethyl 2-ethyl-6,6-dimethyl-2-cyclohexenecarboxylate, ethyl 2,3,6,6-tetramethyl-2-cyclohexenecarboxylate, and ethyl 2-methyl-1,3-dioxolane-2-ethyl acetate;

[0127] Esters of aryl aliphatic alcohols and aliphatic carboxylic acids, such as benzoyl acetate, benzoyl propionate, benzoyl isobutyrate, benzoyl isovalerate, 2-phenylethyl acetate, 2-phenylethyl propionate, 2-phenylethyl isobutyrate, 2-phenylethyl isovalerate, 1-phenylethyl acetate, α-trichloromethylbenzyl acetate, α,α-dimethylphenyl ethyl acetate, α,α-dimethylphenyl ethyl ethyl butyrate, cinnamyl acetate, 2-phenoxyethyl isobutyrate, and 4-methoxybenzyl acetate;

[0128] Heterocyclic compounds, such as 2,5-dimethyl-4-hydroxy-2H-furan-3-one, 2-ethyl-4-hydroxy-5-methyl-2H-furan-3-one, 3-hydroxy-2-methyl-4H-pyran-4-one, and 2-ethyl-3-hydroxy-4H-pyran-4-one;

[0129] Hydrocarbons, such as 3-carene; α-pinene; β-pinene; α-terpinene; γ-terpinene; p-cymene; bisabolene; camphene; caryophyllene; cedrene; farnesene; limonene; longifolene; myrcene; ocimene; arbutin; (E,Z)-1,3,5-undecanetriene; styrene; diphenylmethane; aliphatic alcohols, such as hexanol; octanol; 3-octanol; 2,6-dimethylheptanol; 2-methyl-2-heptanol; 2-methyl-2- -Octanol; (E)-2-Hexenol; (E)- and (Z)-3-Hexenol; 1-Octen-3-ol; a mixture of 3,4,5,6,6-pentamethyl-3 / 4-hepten-2-ol and 3,5,6,6-tetramethyl-4-methylenehepten-2-ol; (E,Z)-2,6-nonadienol; 3,7-dimethyl-7-methoxyoct-2-ol; 9-decenol; 10-undecenol; 4-methyl-3-decen-5-ol;

[0130] Lactones, such as 1,4-octyl lactone, 3-methyl-1,4-octyl lactone, 1,4-nonyl lactone, 1,4-decyl lactone, 8-decen-1,4-lactone, 1,4-undecyl lactone, 1,4-dodecyl lactone, 1,5-decyl lactone, 1,5-dodecyl lactone, 4-methyl-1,4-decyl lactone, 1,15-pentadecanolone, cis- and trans-11-pentadecane-1,15-lactone, cis- and trans- 12-Pentadecene-1,15-lactone; 1,16-Hexadecyllactone, 9-Hexadecene-1,16-lactone, 10-O-1,16-Hexadecyllactone, 11-O-1,16-Hexadecyllactone, 12-O-1,16-Hexadecyllactone, vinyl-1,12-dodecyl-dilactone, vinyl-1,13-tridecyl-dilactone, coumarin, 2,3-dihydrocoumarin, octahydrocoumarin.

[0131] Phenols, phenyl ethers, and phenyl esters, such as Tarragol; anethole; eugenol; eugenyl methyl ether; isoeugenol; isoeugenyl methyl ether; thymol; carvacrol; diphenyl ether; β-naphthyl methyl ether; β-naphthyl ethyl ether; β-naphthyl isobutyl ether; 1,4-dimethoxybenzene; eugenol acetate; 2-methoxy-4-methylphenol; 2-ethoxy-5-(1-propenyl)phenol; p-cresol phenyl acetate;

[0132] Nitrogen-containing aromatic compounds, such as 2,4,6-trinitro-1,3-dimethyl-5-tert-butylbenzene, 3,5-dinitro-2,6-dimethyl-4-tert-butylacetophenone, cinnamic acid nitrile, 3-methyl-5-phenyl-2-pentenic acid nitrile, 3-methyl-5-phenylpentanic acid nitrile, methyl anthranilate, N-methyl anthranilate, methyl anthranilate and Schiff bases of 7-hydroxy-3,7-dimethyloctanal, 2-methyl-3-(4-tert-butylphenyl)propanal or 2,4-dimethyl-3-cyclohexenecarboxaldehyde, 6-isopropylquinoline, 6-isobutylquinoline, 6-sec-butylquinoline, 2-(3-phenylpropyl)pyridine, indole, skatole, 2-methoxy-3-isopropylpyrazine, 2-isobutyl-3-methoxypyrazine Preferred perfumes with a woody note

[0133] Suitable spices with woody notes are selected from the following group: Preferred perfumes with an amber note

[0134] Suitable fragrances with amber notes are selected from the following group: Preferred perfumes with a fruity note

[0135] Suitable fruity fragrances are selected from the following group: Preferred perfumes with a musky note

[0136] Suitable fragrances with a musky note are selected from the following group: dye

[0137] Suitable dyes are, for example, the publications of the German Research Society for Dyes, such as the "Kosmetische" (Dyes of the German Research Society). Any of the substances listed in Verlag Chemie, Weinheim, 1984, pp. 81-106 that are suitable for and approved for use in cosmetics. Examples include Carmine A (CI16255), Patent Blue V (CI42051), Indigo (CI73015), Folate (CI75810), Quinoline Yellow (CI47005), Titanium Dioxide (CI77891), Indanthrene Blue RS (CI69800), and Madder Red (CI58000). Luminol can also be used as a fluorescent dye. Advantageous coloring pigments are, for example, titanium dioxide, mica, iron oxides (e.g., Fe2O3, Fe3O4, FeO(OH)) and / or tin oxide. Advantageous dyes are, for example, Carmine, Berlin Blue, Chromium Oxide Green, Ultramarine, and / or Manganese Violet. Composition

[0138] The preferred compositions according to the invention are selected from products for treating, protecting, caring for and cleansing skin and / or hair or as cosmetic products, preferably as leave-on products (meaning one or more compounds remain on the skin and / or hair for a longer time compared to rinse-off products).

[0139] The formulations according to the invention are preferably in the form of emulsions, such as W / O (water-in-oil), O / W (oil-in-water), W / O / W (oil-in-oil-in-water), O / W / O (oil-in-water-in-oil), PIT emulsions, Pickling emulsions, low-oil emulsions, micron-emulsions or nano-emulsions, solutions, for example, in oil (fatty oils or fatty acid esters, especially C6-C). 32 Fatty acid C2-C 30Esters or solutions in silicone oils, dispersions, suspensions, creams, emulsions or milks, depending on the preparation method and ingredients; gels (including hydrogels, aqueous dispersions, oleogels); aerosols (e.g., pump sprays or propellant-containing sprays) or foams or impregnation solutions for wiping cosmetics; detergents such as soaps, synthetic detergents, washes, shower and bath preparations, bath products (capsules, oils, tablets, salts, bath salts, soaps, etc.); effervescent preparations; skin care products such as emulsions (as described above), ointments, pastes, gels (as described above), oils, sesame oils, whey, powders (e.g., face powder, body powder), perfumes, eau de toilette, aftershave, face masks, eyebrow pencils, lipsticks, roll-ons, pumps, aerosols (foaming, non-foaming) Foaming or post-foaming products, deodorants and / or antiperspirants, mouthwash and oral cleansers, foot care products (including exfoliants and deodorants), insect repellents, sunscreens, after-sun products, shaving products, aftershave creams, pre- and post-shave shampoos, depilatory agents, hair care products such as shampoos (including 2-in-1 shampoos, anti-dandruff shampoos, baby shampoos, dry hair shampoos, concentrated shampoos), conditioners, hair growth oils, hair growth solutions, hair dyes, styling creams, hair oils, perming and curling solutions, hair gels, styling aids (such as gels or waxes), hair smoothing agents (conditioners, relaxants), hair dyes such as short-term direct hair dyes, semi-permanent hair dyes, permanent hair dyes, conditioners, hair mousses, eye care products, cosmetics, makeup removers, or baby products.

[0140] The content of auxiliary substances and additives is 5 to 99% by weight, preferably 10 to 80% by weight, based on the total amount of the formulation. Those skilled in the art can readily determine the amount of cosmetic or skin care auxiliary substances, additives, and fragrances used in each case by simple trial and error, based on the properties of the specific product.

[0141] The formulation may also contain up to 99% by weight, preferably about 5% to about 80% by weight, and more preferably about 10% to about 50% or about 60% to about 80% by weight, water, based on the total weight of the formulation. INDUSTRIAL APPLICABILITY

[0142] Another object of the present invention relates to a non-therapeutic cosmetic method for achieving at least one, two, or all of the following effects: - Improve the extracellular matrix; and / or -Prevention and / or treatment of loss of skin elasticity; -Prevention and / or treatment of decreased skin firmness; Includes the following steps: (i) A formulation comprising or consisting of the following ingredients: (a) Hydroxypinazone retinate (I) and optional (b) at least one C1-C6 alkyl monoester and / or diester of a dicarboxylic acid, and / or (c) at least one antioxidant, and (ii) Apply the preparation topically to human skin.

[0143] It should be emphasized that all preferred embodiments, especially those involving the selection, amount and proportion of active ingredients, are also applicable to the methods disclosed above, and therefore any repetition is redundant. Example _____________________________________________________________________ RNA sequencing of a 3D reconstructed epidermal skin model.

[0144] The 3D model reconstructed by EpiDerm (MatTek, Bratislava, Slovakia) was cultured for 72 hours. Then SymRenew was applied daily for 5 consecutive days. TM HPR (INCI: diisopropyl adipate, hydroxypinazone retinate, tocopherol) and benchmark all-trans retinol. This composition is a specially designed blend of hydroxypinazone retinate to provide good stability. Three biological replicates were analyzed for each experimental condition. EpiDerm models were collected in RNA lysis buffer. RNA was isolated using the Quiagen RNAeasy Mini Kit (Quiagen, Hilden, Germany). Samples were processed using Illumina TruSeq to prepare stranded, poly(A)-enriched RNA libraries. Sequencing was performed on the IlluminaNextSeq v2.5 platform, with approximately 30 million reads per sample at 75 bp length. RNA sequencing data analysis

[0145] After base recognition, demultiplexing, and removal of Illumina adapter remnants, the data were aligned to the GRCh38 genome, and the FPKM values ​​for each gene were obtained. The FPKM values ​​were averaged and normalized to untreated control samples or ATRA-treated samples. Genes with a natural logarithmic fold change ≤-1 or ≥1 and a p-value <0.05 (excluding genes with FPKM <3) were considered to have significant differences in expression levels. Functional enrichment and cluster analysis were performed using DAVID Bioinformatics Resource 6.8. Functional clusters with a Bonferroni-corrected p-value ≤0.05 were considered significant. result

[0146] RNA sequencing analysis revealed that HPR altered the expression of 2747 genes compared to the untreated sample. All-trans retinol altered the expression of 3893 genes compared to the untreated control. To demonstrate the advantages of this component over all-trans retinol, we analyzed 493 genes regulated solely by HPR, not by all-trans retinol. Figure 3 Among these genes, we found genes associated with the upregulation of extracellular matrix organization, extracellular matrix, and collagen, indicating improved basement membrane formation, dermal-epidermal anchoring, and skin elasticity. Furthermore, protein digestion and absorption were promoted, which is crucial for protecting skin cells from the aging process and improving stratum corneum formation during differentiation (see [link to relevant documentation]). Figure 1 and Figure 2 ).

[0147] Next, we investigated whether this component could improve gene expression compared to all-trans retinol. Therefore, we used all-trans retinol gene expression data as a control for standardization. We found that 843 genes showed differential expression compared to all-trans retinol. Figure 4 The results showed that HPR downregulated processes associated with extracellular matrix degradation, collagen catabolism, and interferon-γ signaling. This indicates that the component inhibits the degradation of the extracellular matrix and collagen and is less irritating than all-trans retinol. On the other hand, it induced the expression of genes associated with the keratin capsule, peptide crosslinking, keratinocyte differentiation, and cell cycle. Furthermore, we compared the expression of kallikrein, keratin, and other genes associated with keratinocyte differentiation. For example, keratin 1 / 10, keratin 4 / 13, and filaggrin (… Figure 5 The expression level of [a specific ingredient] was higher than that of the retinol-treated sample, supporting the gene ontology data. This clearly indicates that the ingredient exhibits greater activity in keratinocyte differentiation, and therefore, at equimolar levels, provides a greater improvement in epidermal thickening compared to all-trans retinol (see [link to relevant documentation]). Figure 3 , 4 and 5). Discussion and Conclusion

[0148] This study compared the molecular and phenotypic effects of all-trans retinol (HPR) and this ingredient (a pinacolone-based alternative derivative). Results showed that HPR exhibited higher transcriptomic activity in keratinocyte differentiation and barrier formation compared to HPR. For example, this ingredient was superior to HPR because it better promoted the organization of the extracellular matrix and collagen formation, thereby strengthening the basement membrane. It was also less irritating due to its ability to inhibit interferon-mediated signaling. Furthermore, compared to HPR, this ingredient showed higher activity in keratinocyte differentiation, resulting in a greater improvement in epidermal thickening at equimolar concentrations. In in vivo wrinkle studies, both this ingredient and HPR significantly reduced wrinkles with similar efficacy. Therefore, we conclude that this ingredient is a safe and effective alternative anti-aging compound suitable for use in anti-aging cosmetic formulations. Attached Figure Description Figure 1 The Venn diagram illustrates the differences in the genes regulated by this component compared to all-trans retinol. Figure 2 Left panel: Venn diagram showing 2254 genes (red border) regulated by both this component and all-trans retinol. Right panel: Gene ontology cluster analysis of the 2254 genes regulated by both this component and all-trans retinol. Figure 3 Left panel: Venn diagram highlighting gene categories (red border), showing 493 genes regulated solely by this component and not by all-trans retinol. Right panel: Gene ontology cluster analysis of the 493 genes regulated solely by this component. Figure 4 Gene ontology clustering analysis of 843 genes regulated solely by this component, distinguishing between upregulated and downregulated genes. Figure 5 Compared to all-trans retinol, selected genes involved in keratinocyte differentiation and barrier formation are upregulated. Figure 6: Left: Image showing wrinkle reduction in in vivo studies; Right: Bar chart showing the effect of this ingredient compared to all-trans retinol. *p<0.05 compared to placebo. Examples of cosmetic composition formulations The following examples F1 to F18 illustrate various cosmetic composition formulations. This represents a formulation containing hydroxypinazone retinate, diisopropyl adipate, and tocopherol. Table F1 O / W emulsion (amount in weight %) Table F2 Body lotion (amount used in weight %) Table F3 Face cream (amount used in % by weight) Table F4 Face cream (amount used in % by weight) Table F5 Hand cream and body cream (amount used in % by weight) Table F6 Face cream (amount used in % by weight) Table F7 Moisturizing body cream (amount used in % by weight) Table F8 Anti-wrinkle cream (amount used in weight %) Table F9 Disinfecting functional skin oil (dosage by weight%) Table F10 Moisturizing and disinfecting face mask (dosage by weight%) Table F11 Disinfectant gel can be sprayed (dosage is in % by weight). Table F12 Cosmetic sunscreen composition (in weight %) Table F13 Sunscreen spray (dosage by weight%) Table F14 Sunscreen spray O / W.SPE 15-20 (dosage by weight%) Table F15 Sunscreen cream (w / o). SPF 40 (amount used in weight %) Table F16 Sunscreen lotion (W / O) (Amount used in weight %) Table F17 After-sun gel (amount by weight%) Table F18 After-sun lotion (amount by weight%) CITED LITERATURE [1]Heyman,RA,Mangelsdorf,DJ,Dyck,J Aet al(1992)9-cis retinoic acid is a high affinity ligand for the retinoid X receptor.Cel 68(2)397-406 [2]Levin,AA,Sturzenbecker,LJ,Kazmer,Set al(1992)9-cis retinoic acidstereoisomer binds and activates the nuclear receptor RXR alpha.Nature355(6358)359-361 [3]Piskunov,A,&Rochette-Egly,C(2012)A retinoic acid receptor RARαpoolpresent in membrane lipid rafts forms complexes with G proteinαQ to activatep38MAPK.Oncogene 31(28)3333-3345 [4] S,Alvarez,S,de Lera,A Ret al(2007)Rapid,Nongenomic Actions ofRetinoic Acid on Phosphatidylinositol-3-Kinase Signaling Pathway Mediated by the Retinoic Acid Re-ceptor.Molecular Endocrinology 21(10)2391-2402 [5]Szymański, Skopek, R, Palusińska, M et al (2020) Retinoic Acid and Its Derivatives in Skin. Cels 9(12)2660 [6] H(2011) Regulation of keratin expression by retinoids. Dermato - endocrinology 3(3)136 - 140 [7]Hubbard, B A, Unger, J G, & Rohrich, R J(2014) Reversal of Skin Aging with Topical Retinoids. Plastic and reconstructive surgery 133(4) [8]Baumann, L(2007) Skin ageing and its treatment. J Pathol 211(2)241 - 251 [9]Puizina - Ivic, N, Miric, L, Carija, A et al Modern approach to topical treatment of aging skin. Col Antropol 34(3)1145 - 1153

[10] Isoherranen, N, & Zhong, G(2019) Biochemical and physiological importance of the CYP26 retinoic acid hydroxylases. Pharmacology & Therapeutics 204 107400

[10] Yin, S, Luo, J, Qian, A et al(2013) Retinoids activate the irritant receptor TRPV1 and produce sensory hypersensitivity. Journal of Clinical Investigation 123(9)3941 - 3951

[12] Varani,J,Fay,K,&Perone,P(2007)MDI 301,a non-irritating retinoid,induces changes in human skin that underlie repair.Archives of DermatologicalResearch 298(9)439-448

Claims

1. A formulation of a medicament used for the prevention and / or treatment of human skin dysfunction, comprising or consisting of the following ingredients. (a) Hydroxypinazone retinate (I) and optional (b) at least one C1-C6 alkyl monoester and / or diester of a dicarboxylic acid and / or (c) At least one antioxidant.

2. A formulation for use according to claim 1, wherein the dysfunction is selected from the group consisting of: Ellers-Danlos syndrome; • Skin laxity; • Elastic fibrolysis; ·cellulitis; • Ligament laxity; • Loss of skin elasticity; • Loss of skin firmness.

3. A formulation for use according to claims 1 and / or 2, wherein component (b) conforms to formula (II). R 1 COO-(CH2) n (CH=CH) p (CH2) q COOR 2 (II) Where R 1 and R 2 Each of the following groups independently represents a straight-chain or branched alkyl or alkenyl group having 1 to 6 carbon atoms, n and q independently represent integers from 1 to 6, p is 0 or 1, and the condition is R. 1 and R 2 It cannot be hydrogen at the same time.

4. A formulation for use according to any one of claims 1 to 3, wherein component (b) is diisopropyl adipate.

5. A formulation for use according to any one of claims 1 to 4, wherein components (a) and (b) are present in a weight ratio of about 1:99 to about 25:

75.

6. A formulation for use according to any one of claims 1 to 5, wherein the antioxidant is selected from the group comprising tocopherol, tocopheryl acetate, tocopheryl palmitate, ascorbic acid, (deoxy)ribonucleic acid and its cleavage products, β-glucan, retinol, bisabolol, allantoin, phytanetriol, panthenol, AHA acid, amino acids, ceramides, pseudoceramides, essential oils, plant extracts and vitamin complexes.

7. A formulation for use according to any one of claims 1 to 6, wherein the antioxidant content is from about 0.1 to about 5% by weight, based on the formulation.

8. A formulation for use according to any one of claims 1 to 7, wherein the formulation is used in a pharmaceutical composition, wherein the content of component (a) ranges from about 0.0001 to about 2% by weight, preferably from about 0.001 to about 0.5% by weight, and more preferably from about 0.01 to about 0.2% by weight.

9. A formulation for use according to claim 8, wherein the pharmaceutical composition is a lotion, cream, spray, or ointment, all applied topically to human skin.

10. A formulation for non-therapeutic, cosmetic use in combating human skin aging, wherein the formulation contains or is composed of the following ingredients: (a) Hydroxypinazone retinate (I) and optional (b) at least one C1-C6 alkyl monoester and / or diester of a dicarboxylic acid and / or (c) At least one antioxidant.

11. A cosmetic composition comprising a formulation containing or consisting of the following ingredients. (a) Hydroxypinazone retinate (I) and optional (b) at least one C1-C6 alkyl monoester and / or diester of a dicarboxylic acid and / or (c) At least one antioxidant.

12. The composition of claim 11, wherein the formulation comprises or is composed of the following components: (a) Hydroxypinazone retinate (b) diisopropyl adipate, and (c) Tocopherol.

13. The composition according to claim 11 and / or 12, wherein the formulation comprises or consists of components (a), (b) and (c) in an amount of about 0.1 to 10 wt.%.

14. The composition according to any one of claims 11 to 13, further comprising at least one of the following adjuvants. - Antipruritic agent; - Anti-inflammatory agents; - Anti-acne agents; - Weight loss agents; - physiological cooling agents and / or; - Skin care products.

15. A non-therapeutic cosmetic method for achieving at least one, two, three, or all of the following effects. - Improve the extracellular matrix; and / or -Prevention and / or treatment of loss of skin elasticity; and / or -Prevention and / or treatment of decreased skin firmness; Includes the following steps: (i) A formulation comprising or consisting of the following ingredients: (a) Hydroxypinazone retinate (I) and optional (b) at least one C1-C6 alkyl monoester and / or diester of a dicarboxylic acid, and / or (c) at least one antioxidant, and (ii) Apply the preparation topically to human skin.

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