Personal care rinse-off formulation

Abstract

There is provided an aqueous personal care rinse-off formulation, the aqueous personal care rinse-off formulation comprising: a dermatologically acceptable aqueous vehicle; a dermatologically acceptable cleansing surfactant, wherein the dermatologically acceptable cleansing surfactant comprises an anionic surfactant; and an alkyl polysaccharide thickener; wherein the alkyl polysaccharide thickener comprises from 50% to 100% by weight, based on the weight of the alkyl polysaccharide thickener, of a linear alkyl polysaccharide of formula A, R-O-(S) nH (A) wherein R is a linear C9-15 alkyl group; wherein n is an average value from 1 to 2.5, and wherein S is a monosaccharide selected from the group consisting of ribulose, xylulose, ribose, arabinose, xylose, lyxose and mixtures thereof; and wherein 70% to 100% by weight, based on the weight of monosaccharide S in the linear alkyl polysaccharide of formula A, of the monosaccharide S is xylose.

Description

[0001] This invention relates to an aqueous personal care wash-off formulation. Specifically, this invention relates to an aqueous personal care wash-off formulation comprising: a dermatologically acceptable aqueous mediator; a dermatologically acceptable cleansing surfactant, wherein the dermatologically acceptable cleansing surfactant comprises anionic surfactants; and an alkyl polysaccharide thickener, wherein the alkyl polysaccharide thickener comprises 50% to 100% by weight of a linear alkyl polysaccharide of formula A based on the weight of the alkyl polysaccharide thickener.

[0002] RO-(S) n H(A)

[0003] Where R is a straight chain C 9-15 Alkyl group; wherein n is an average of 1 to 2.5, and wherein S is a monosaccharide selected from the group consisting of ribulose, xylulose, ribose, arabinose, xylose, lysose, and mixtures thereof; and wherein 70% to 100% by weight of the monosaccharide S in the linear alkyl polysaccharide based on Formula A is xylose; provided that the alkyl polysaccharide thickener contains <15% by weight of the branched alkyl polysaccharide of Formula I based on the alkyl polysaccharide thickener.

[0004] (I)

[0005] Where R 1 Is it a straight chain or a branched chain C? 3-4 alkyl groups; wherein R 2 Is it a straight chain or a branched chain C? 5-6 alkyl groups; wherein G 1 It is a monosaccharide having 4 to 6 carbon atoms, wherein x is 1.1 to 4; provided that the alkyl polysaccharide thickener contains <1.5% by weight of a branched alkyl polysaccharide of formula II based on the weight of the alkyl polysaccharide thickener.

[0006] R 3 -(OG 2 ) y (II)

[0007] Where R 3 It is an alkyl or alkenyl moiety containing 7 to 30 carbon atoms, wherein the alkyl or alkenyl moiety is in R 3 A branch is formed at a carbon position of 2 or higher, wherein the branch is selected from the group consisting of: methyl, ethyl, isopropyl, n-propyl, butyl, pentyl, hexyl, and mixtures thereof; wherein G 2y is the sugar fraction selected from the group consisting of: glucose, fructose, mannose, galactose, tarose, gulose, allose, azoose, idose, arabinose, xylose, lysoose, ribose, and mixtures thereof, where y is the average of ≥2.

[0008] Surfactant-based formulations for wash-off personal care applications (most commonly formulated using sulfate-based anionic surfactants mixed with amphoteric surfactants) are typically thickened by adding sodium chloride, which induces a globular-to-worm-like micelle transition in the surfactant's microstructure, resulting in the desired viscosity. However, thickening by adding a single salt can cause problems, including undesirable interactions with deposition aid polymers and reduced performance; decreased stability of emulsions used in personal care formulations; and limited efficacy of thickening advanced ethoxylated sulfate surfactants (e.g., sodium lauryl ether sulfate (3EO SLES) with an average degree of ethoxylation of 3).

[0009] To address these issues with salt thickening, polymer rheology modifiers have been used alone or in combination with salt to provide the desired thickening in personal care formulations. However, conventional polymer rheology modifiers tend to exhibit poor biodegradability, are often derived from petroleum, and are therefore not considered environmentally acceptable or renewable materials.

[0010] Alkyl polyglucosides have been proposed as alternatives to thickeners in mixed surfactant personal care systems. However, such alkyl polyglucosides have shown limited effectiveness in thickening sulfate-based surfactant systems to desired viscosities at low usage levels.

[0011] Therefore, there is still a need for alternative thickeners that can effectively thicken a wide range of sulfate-based personal care formulations, and are also naturally derived and biodegradable with improved sustainability characteristics.

[0012] This invention provides an aqueous personal care wash-off formulation comprising: a dermatologically acceptable aqueous mediator; a dermatologically acceptable cleansing surfactant, wherein the dermatologically acceptable cleansing surfactant comprises anionic surfactant; and an alkyl polysaccharide thickener; wherein the alkyl polysaccharide thickener comprises 50% to 100% by weight of a linear alkyl polysaccharide of formula A based on the weight of the alkyl polysaccharide thickener.

[0013] RO-(S) n H(A)

[0014] Where R is a straight chain C 9-15Alkyl group; wherein n is an average of 1 to 2.5, and wherein S is a monosaccharide selected from the group consisting of ribulose, xylulose, ribose, arabinose, xylose, lysose, and mixtures thereof; and wherein 70% to 100% by weight of the monosaccharide S in the linear alkyl polysaccharide based on Formula A is xylose; provided that the alkyl polysaccharide thickener contains <15% by weight of the branched alkyl polysaccharide of Formula I based on the alkyl polysaccharide thickener.

[0015] (I)

[0016] Where R 1 Is it a straight chain or a branched chain C? 3-4 alkyl groups; wherein R 2 Is it a straight chain or a branched chain C? 5-6 alkyl groups; wherein G 1 It is a monosaccharide having 4 to 6 carbon atoms, wherein x is 1.1 to 4; and the prerequisite is that the alkyl polysaccharide thickener contains <1.5% by weight of a branched alkyl polysaccharide of formula II based on the weight of the alkyl polysaccharide thickener.

[0017] R 3 -(OG 2 ) y (II)

[0018] Where R 3 It is an alkyl or alkenyl moiety containing 7 to 30 carbon atoms, wherein the alkyl or alkenyl moiety is in R 3 A branch is formed at a carbon position of 2 or higher, wherein the branch is selected from the group consisting of: methyl, ethyl, isopropyl, n-propyl, butyl, pentyl, hexyl, and mixtures thereof; wherein G 2 It is the sugar fraction selected from the group consisting of: glucose, fructose, mannose, galactose, tarose, gulose, allose, azoose, idose, arabinose, xylose, lysoose, ribose, and mixtures thereof; and where y is the average value of ≥2.

[0019] This invention provides an aqueous personal care wash-off formulation comprising: a dermatologically acceptable aqueous mediator; a dermatologically acceptable cleansing surfactant, wherein the dermatologically acceptable cleansing surfactant comprises anionic surfactant; and an alkyl polysaccharide thickener; wherein the alkyl polysaccharide thickener comprises 50% to 100% by weight of a linear alkyl polysaccharide of formula A based on the weight of the alkyl polysaccharide thickener.

[0020] RO-(S) n H(A)

[0021] Where R is a straight chain C 9-15Alkyl group; wherein n is an average of 1 to 2.5, and wherein S is a monosaccharide selected from the group consisting of ribulose, xylulose, ribose, arabinose, xylose, lysose, and mixtures thereof; and wherein 70% to 100% by weight of the monosaccharide S in the linear alkyl polysaccharide based on Formula A is xylose; provided that the alkyl polysaccharide thickener contains <15% by weight of the branched alkyl polysaccharide of Formula I based on the alkyl polysaccharide thickener.

[0022] (I)

[0023] Where R 1 Is it a straight chain or a branched chain C? 3-4 alkyl groups; wherein R 2 Is it a straight chain or a branched chain C? 5-6 alkyl groups; wherein G 1 It is a monosaccharide having 4 to 6 carbon atoms, wherein x is 1.1 to 4; provided that the alkyl polysaccharide thickener contains <1.5% by weight of a branched alkyl polysaccharide of formula II based on the weight of the alkyl polysaccharide thickener.

[0024] R 3 -(OG 2 ) y (II)

[0025] Where R 3 It is an alkyl or alkenyl moiety containing 7 to 30 carbon atoms, wherein the alkyl or alkenyl moiety is in R 3 A branch is formed at a carbon position of 2 or higher, wherein the branch is selected from the group consisting of: methyl, ethyl, isopropyl, n-propyl, butyl, pentyl, hexyl, and mixtures thereof; wherein G 2 It is a sugar fraction selected from the group consisting of: glucose, fructose, mannose, galactose, tarose, gulose, allose, azoose, idose, arabinose, xylose, lysoose, ribose, and mixtures thereof, wherein y is an average value of ≥2; and wherein the viscosity of the aqueous personal care wash-off formulation at 21°C is ≥2,000 cP.

[0026] The present invention provides a method for cleaning at least one of mammalian skin and hair, the method comprising: applying the aqueous personal care wash-off formulation of the present invention to the skin or hair of a mammal; and rinsing the aqueous personal care wash-off formulation off the skin or hair with rinsing water. Detailed Implementation

[0027] We have surprisingly discovered that aqueous personal care rinse-off formulations containing sulfate-based surfactants can be effectively thickened using alkyl polysaccharide thickeners; wherein the alkyl polysaccharide thickener comprises 50% to 100% by weight of a linear alkyl polysaccharide of formula A based on the weight of the alkyl polysaccharide thickener.

[0028] RO-(S) n H(A)

[0029] Where R is a straight chain C 9-15 An alkyl group; wherein n is an average of 1 to 2.5, and wherein S is a monosaccharide selected from the group consisting of ribulose, xylulose, ribose, arabinose, xylose, lysoose, and mixtures thereof; and wherein 70% to 100% by weight of the monosaccharide S in the linear alkyl polysaccharide of Formula A is xylose; and the linear alkyl polysaccharide of Formula A of the present invention provides significantly improved thickening properties in such formulations compared to linear alkyl polyglucosides.

[0030] Unless otherwise specified, ratios, percentages, parts, etc. are all by weight.

[0031] As used herein, unless otherwise specified, the phrase "molecular weight" or MW refers to the weight-average molecular weight as measured in a conventional manner using gel permeation chromatography (GPC) and conventional standards, such as polystyrene molecular weight standards. GPC techniques are discussed in detail in *Modern Size-Exclusion Liquid Chromatography – Practice of Gel Permeation and Gel Filtration Chromatography*, 2nd Edition, AM Striegel, WW Yau, JJ Kirkland, DD Bly; John Wiley & Sons, Inc. 2009. Molecular weights are reported in Daltons or, equivalently, g / mol.

[0032] As used herein and in the appended claims, the term "dermatologically acceptable" refers to an ingredient typically used for topical application to the skin, and it is intended to emphasize that toxic substances present in amounts typically found in skin care compositions are not considered part of this invention.

[0033] Preferably, the aqueous personal care wash-off formulation of the present invention is selected from the group consisting of: shampoo, conditioning shampoo, bath product, exfoliating bath product, facial cleanser, exfoliating facial cleanser, and liquid hand soap. More preferably, the aqueous personal care wash-off formulation of the present invention is selected from the group consisting of: shampoo, conditioning shampoo, bath product, facial cleanser, and liquid hand soap. Most preferably, the aqueous personal care wash-off formulation of the present invention is selected from the group consisting of: shampoo and conditioning shampoo.

[0034] Preferably, the aqueous personal care rinse-off formulation of the present invention comprises: a dermatologically acceptable aqueous medium (preferably, wherein the aqueous personal care rinse-off formulation comprises 25% to 98.9% by weight (preferably, 30% to 97.5% by weight; more preferably, 40% to 96.4% by weight; most preferably, 50% to 95% by weight) based on the weight of the aqueous personal care rinse-off formulation); a dermatologically acceptable cleansing surfactant (preferably, wherein the aqueous personal care rinse-off formulation comprises 1% to 50% by weight (preferably, 2% to 40% by weight; more preferably, 3% to 30% by weight; most preferably, 4% to 20% by weight) based on the weight of the aqueous personal care rinse-off formulation); and wherein the dermatologically acceptable cleansing surfactant... The active agent comprises anionic surfactants; and an alkyl polysaccharide thickener (preferably, wherein the aqueous personal care rinse-off formulation comprises 0.1% to 30% by weight (preferably, 0.5% to 25% by weight; more preferably, 0.6% to 20% by weight; most preferably, 1% to 15% by weight) of an alkyl polysaccharide thickener based on the weight of the aqueous personal care rinse-off formulation, wherein the alkyl polysaccharide thickener comprises 50% to 100% by weight (preferably, 75% to 100% by weight; more preferably, 80% to 100% by weight; still more preferably, 90% to 100% by weight; still more preferably, 95% to 100% by weight; still even more preferably, 98% to 100% by weight; still even more preferably, 99% to 100% by weight; most preferably, 100% by weight) of a linear alkyl polysaccharide of formula A based on the weight of the alkyl polysaccharide thickener.

[0035] RO-(S) n H(A)

[0036] Where R is a straight chain C 9-15 alkyl group (preferably, C 9-14 Alkyl groups; more preferably, C 9-13 Alkyl group; most preferably, C 10-12Alkyl groups); wherein g is an average of 1 to 2.5 (preferably 1.1 to 2; more preferably 1.1 to 1.75; most preferably 1.15 to 1.5), and wherein S is a monosaccharide selected from the group consisting of ribulose, xylulose, ribose, arabinose, xylose, lysose, and mixtures thereof (preferably arabinose, xylose, and mixtures thereof; most preferably xylose); and wherein the monosaccharide S in the linear alkyl polysaccharide of formula A is 70% to 100% by weight (preferably 80% to 100% by weight; more preferably 85% to 10% by weight). 0% by weight; more preferably, 90% by weight to 100% by weight; even more preferably, 95% by weight to 100% by weight; still more preferably, 98% by weight to 100% by weight; most preferably, 99% by weight to 100% by weight) is xylose; provided that the alkyl polysaccharide thickener contains <15% by weight (preferably, <10% by weight; more preferably, <1% by weight; still more preferably, <0.1% by weight; even more preferably, 0.01% by weight; still more preferably, 0.001% by weight; most preferably, less than the detectable limit) of a branched alkyl polysaccharide of Formula I based on the weight of the alkyl polysaccharide thickener.

[0037] (I)

[0038] Where R 1 Is it a straight chain or a branched chain C? 3-4 alkyl groups; wherein R 2 Is it a straight chain or a branched chain C? 5-6 alkyl groups; wherein G 1 It is a monosaccharide having 4 to 6 carbon atoms and wherein x is 1.1 to 4; and the prerequisite is that the alkyl polysaccharide thickener contains <1.5% by weight (preferably, <1% by weight; more preferably, <0.5% by weight; still more preferably, <0.1% by weight; even more preferably, <0.01% by weight; still even more preferably, <0.001% by weight; still even more preferably, <0.0001% by weight; most preferably, less than the detectable limit) of a branched alkyl polysaccharide of Formula II.

[0039] R 3 -(OG 2 ) y (II)

[0040] Where R 3 It is an alkyl or alkenyl moiety containing 7 to 30 carbon atoms, wherein the alkyl or alkenyl moiety is in R 3 A branch is formed at a carbon position of 2 or higher, wherein the branch is selected from the group consisting of: methyl, ethyl, isopropyl, n-propyl, butyl, pentyl, hexyl, and mixtures thereof; wherein G 2It is a sugar fraction selected from the group consisting of: glucose, fructose, mannose, galactose, tarose, gulose, allose, azoose, idose, arabinose, xylose, lysoose, ribose, and mixtures thereof, wherein y is an average of ≥2 (preferably 2 to 10).

[0041] More preferably, the aqueous personal care rinse-off formulation of the present invention comprises: a dermatologically acceptable aqueous medium (preferably, wherein the aqueous personal care rinse-off formulation comprises 25% to 98.9% by weight (preferably, 30% to 97.5% by weight; more preferably, 40% to 96.4% by weight; most preferably, 50% to 95% by weight) based on the weight of the aqueous personal care rinse-off formulation); a dermatologically acceptable cleansing surfactant (preferably, wherein the aqueous personal care rinse-off formulation comprises 1% to 50% by weight (preferably, 2% to 40% by weight; more preferably, 3% to 30% by weight; most preferably, 4% to 20% by weight) based on the weight of the aqueous personal care rinse-off formulation); and wherein the dermatologically acceptable cleansing surfactant... The active agent comprises anionic surfactant; and an alkyl polysaccharide thickener (preferably, wherein the aqueous personal care rinse-off formulation comprises 0.1% to 30% by weight (preferably, 0.5% to 25% by weight; more preferably, 0.6% to 20% by weight; most preferably, 1% to 15% by weight) of an alkyl polysaccharide thickener based on the weight of the aqueous personal care rinse-off formulation), wherein the alkyl polysaccharide thickener comprises 50% to 100% by weight (preferably, 75% to 100% by weight; more preferably, 80% to 100% by weight; still more preferably, 90% to 100% by weight; still more preferably, 95% to 100% by weight; still even more preferably, 98% to 100% by weight; still even more preferably, 99% to 100% by weight; most preferably, 100% by weight) of a linear alkyl polysaccharide of formula A based on the weight of the alkyl polysaccharide thickener.

[0042] RO-(S) n H(A)

[0043] Where R is a straight chain C 9-15 alkyl group (preferably, C 9-14 Alkyl groups; more preferably, C 9-13 Alkyl group; most preferably, C 10-12Alkyl groups); wherein g is an average of 1 to 2.5 (preferably 1.1 to 2; more preferably 1.1 to 1.75; most preferably 1.15 to 1.5), and wherein S is a monosaccharide selected from the group consisting of ribulose, xylulose, ribose, arabinose, xylose, lysoose, and mixtures thereof (preferably arabinose, xylose, and mixtures thereof; most preferably xylose); and wherein the monosaccharide S in the linear alkyl polysaccharide of formula A is 70% to 100% by weight (preferably 80% to 100% by weight; more preferably 85% to 100% by weight; still more preferably 90% to 100% by weight; even more preferably 95% to 100% by weight). More preferably, 98% to 100% by weight; most preferably, 99% to 100% by weight) is xylose; wherein the linear alkyl polysaccharide of Formula A accounts for 0.1% to 39% by weight (preferably 1% to 25% by weight) of the combination of the linear alkyl polysaccharide of Formula A and the dermatologically acceptable cleansing surfactant in the aqueous personal care wash-off composition; provided that the alkyl polysaccharide thickener comprises <15% by weight (preferably <10% by weight; more preferably <1% by weight; still more preferably <0.1% by weight; even more preferably 0.01% by weight; still more preferably 0.001% by weight; most preferably, less than the detectable limit) of the branched alkyl polysaccharide of Formula I based on the weight of the alkyl polysaccharide thickener.

[0044] (I)

[0045] Where R 1 Is it a straight chain or a branched chain C? 3-4 alkyl groups; wherein R 2 Is it a straight chain or a branched chain C? 5-6 alkyl groups; wherein G 1 It is a monosaccharide having 4 to 6 carbon atoms and wherein x is 1.1 to 4; and the prerequisite is that the alkyl polysaccharide thickener contains <1.5% by weight (preferably, <1% by weight; more preferably, <0.5% by weight; still more preferably, <0.1% by weight; even more preferably, <0.01% by weight; still even more preferably, <0.001% by weight; still even more preferably, <0.0001% by weight; most preferably, less than the detectable limit) of a branched alkyl polysaccharide of Formula II.

[0046] R 3 -(OG 2 ) y (II)

[0047] Where R 3 It is an alkyl or alkenyl moiety containing 7 to 30 carbon atoms, wherein the alkyl or alkenyl moiety is in R3 A branch is formed at a carbon position of 2 or higher, wherein the branch is selected from the group consisting of: methyl, ethyl, isopropyl, n-propyl, butyl, pentyl, hexyl, and mixtures thereof; wherein G 2 It is a sugar fraction selected from the group consisting of: glucose, fructose, mannose, galactose, tarose, gulose, allose, azoose, idose, arabinose, xylose, lysoose, ribose, and mixtures thereof, wherein y is an average of ≥2 (preferably 2 to 10).

[0048] Preferably, the aqueous personal care wash-off formulation of the present invention comprises a dermatologically acceptable aqueous medium. More preferably, the aqueous personal care wash-off formulation of the present invention comprises 25% to 98.9% by weight (preferably 30% to 97.5% by weight; more preferably 40% to 96.4% by weight; most preferably 50% to 95% by weight) of a dermatologically acceptable aqueous medium based on the weight of the aqueous personal care wash-off formulation. Still more preferably, the aqueous personal care wash-off formulation of the present invention comprises 25% to 98.9% by weight (preferably 30% to 97.5% by weight; more preferably 40% to 96.4% by weight; most preferably 50% to 95% by weight) of a dermatologically acceptable aqueous medium based on the weight of the aqueous personal care wash-off formulation. Wherein, the dermatologically acceptable aqueous medium includes water. More preferably, the aqueous personal care wash-off formulation of the present invention comprises 25% to 98.9% by weight (preferably 30% to 97.5% by weight; more preferably 40% to 96.4% by weight; most preferably 50% to 95% by weight) of a dermatologically acceptable aqueous medium based on the weight of the aqueous personal care wash-off formulation. The dermatologically acceptable aqueous medium is selected from the group consisting of water and aqueous C. 1-4 An alcohol mixture. Most preferably, the aqueous personal care wash-off formulation of the present invention comprises: 25% to 98.9% by weight (preferably 30% to 97.5% by weight; more preferably 40% to 96.4% by weight; most preferably 50% to 95% by weight) of a dermatologically acceptable aqueous medium based on the weight of the aqueous personal care wash-off formulation, wherein the dermatologically acceptable aqueous medium is water.

[0049] Preferably, the water used in the aqueous personal care wash-off formulation of the present invention is at least one of distilled water and deionized water. More preferably, the water used in the aqueous personal care wash-off formulation of the present invention is both distilled and deionized.

[0050] Preferably, the aqueous personal care wash-off formulation of the present invention comprises 1% to 50% by weight (preferably 2% to 40% by weight; more preferably 3% to 30% by weight; most preferably 4% to 20% by weight) of a dermatologically acceptable cleansing surfactant based on the weight of the aqueous personal care wash-off formulation; wherein the dermatologically acceptable cleansing surfactant comprises anionic surfactant. More preferably, the aqueous personal care wash-off formulation of the present invention comprises: 1% to 50% by weight (preferably 2% to 40% by weight; more preferably 3% to 30% by weight; most preferably 4% to 20% by weight) of a dermatologically acceptable cleansing surfactant based on the weight of the aqueous personal care wash-off formulation; wherein the dermatologically acceptable cleansing surfactant comprises anionic surfactants selected from the group consisting of: glycinate (e.g., sodium cocoyl glycinate), taurine (e.g., sodium methyl cocoyl taurate), glutamate (e.g., sodium cocoyl glutamate), sarcosinate (e.g., sodium lauroyl sarcosinate), hydroxyethyl sulfonate (e.g., sodium cocoyl hydroxyethyl sulfonate, sodium lauroyl methyl hydroxyethyl sulfonate), sulfoacetate (e.g., sodium lauryl sulfoacetate), alanine (e.g., sodium cocoyl alanine), sulfate (e.g., sodium laureth sulfate (SLES), sodium lauryl sulfate (SLS)), sulfonate (e.g., C 14-16 Sodium olefin sulfonate), succinate (e.g., disodium lauryl sulfosuccinate), and mixtures thereof. Most preferably, the aqueous personal care wash-off formulation of the present invention comprises: 1% to 50% by weight (preferably 2% to 40% by weight; more preferably 3% to 30% by weight; most preferably 4% to 20% by weight) of a dermatologically acceptable cleansing surfactant based on the weight of the aqueous personal care wash-off formulation; wherein the dermatologically acceptable cleansing surfactant comprises anionic surfactant, which includes sodium lauryl ether sulfate (SLES).

[0051] Preferably, the aqueous personal care wash-off formulation of the present invention comprises 1% to 50% by weight (preferably 2% to 40% by weight; more preferably 3% to 30% by weight; most preferably 4% to 20% by weight) of a dermatologically acceptable cleansing surfactant based on the weight of the aqueous personal care wash-off formulation; wherein the dermatologically acceptable cleansing surfactant comprises a mixture of anionic surfactants and amphoteric surfactants. More preferably, the aqueous personal care wash-off formulation of the present invention comprises: 1% to 50% by weight (preferably 2% to 40% by weight; more preferably 3% to 30% by weight; most preferably 4% to 20% by weight) of a dermatologically acceptable cleansing surfactant based on the weight of the aqueous personal care wash-off formulation; wherein the dermatologically acceptable cleansing surfactant comprises a mixture of anionic surfactant and amphoteric surfactant; wherein the anionic surfactant is selected from the group consisting of: glycinate (e.g., sodium cocoyl glycinate), taurine (e.g., sodium methyl cocoyl taurine), glutamate (e.g., sodium cocoyl glutamate), sarcosinate (e.g., sodium lauroyl sarcosinate), hydroxyethyl sulfonate (e.g., sodium cocoyl hydroxyethyl sulfonate, sodium lauroyl methyl hydroxyethyl sulfonate), sulfoacetate (e.g., sodium lauryl sulfoacetate), alanine (e.g., sodium cocoyl alanine), sulfate (e.g., sodium laureth sulfate (SLES)), sulfonate (e.g., C 14-16 The amphoteric surfactant comprises sodium olefin sulfonate, succinate (e.g., disodium lauryl sulfosuccinate), carboxylates (e.g., sodium lauryl glucocarboxylate), and mixtures thereof; and wherein the amphoteric surfactant is selected from the group consisting of: betaine (e.g., alkyl betaine, such as trimethylglycine and cetyl betaine; and amide betaine, such as cocamidopropyl betaine); amphoteric acetate (e.g., sodium cocamidopropyl acetate); sulfobetaine (e.g., cocamidopropyl hydroxysulfobetaine), and mixtures thereof; most preferably, the aqueous personal care wash-off formulation of the present invention comprises: 1% to 50% by weight (preferably, 2% to 40% by weight; more preferably, 3% to 30% by weight; most preferably, 4% to 20% by weight) of a dermatologically acceptable cleansing surfactant based on the weight of the aqueous personal care wash-off formulation; wherein the dermatologically acceptable cleansing surfactant comprises a mixture of sodium laureth sulfate (SLES) and cocamidopropyl betaine.

[0052] Dermatologically acceptable cleansing surfactants optionally further comprise cationic surfactants. Cationic surfactants include quaternary ammonium compounds (e.g., behenyltrimethylammonium chloride, cetyltrimethylammonium chloride) or amine-based surfactants (e.g., stearamidopropyl dimethylamine).

[0053] Dermatologically acceptable cleansing surfactants optionally further comprise nonionic surfactants, provided that when the dermatologically acceptable cleansing surfactants comprise nonionic surfactants other than alkyl polysaccharide thickeners, the weight ratio of anionic surfactants to nonionic surfactants in the aqueous personal care wash-off formulation is greater than 1:1 (preferably, >2:1; more preferably >2.5:1) (i.e., dermatologically acceptable anionic cleansing surfactants are preferred over any nonionic surfactants that do not contain alkyl polysaccharide thickeners) (i.e., alkyl polysaccharide thickeners are not considered nonionic surfactants for the purpose of anionic to nonionic cleansing surfactant weight ratios). Nonionic surfactants include fatty alcohols (e.g., cetearyl alcohol, stearyl alcohol, cetyl alcohol, lauryl alcohol) and fatty alkanolamides (e.g., cocamidoyl alcohol, cocamidoyl alcohol, diethanolamine, soyamide diethanolamine, lauryl alcohol, oleamide monoisopropanolamine, stearamide monoethanolamine, myristamide monoethanolamine, lauryl alcohol, decanoamide diethanolamine, castor oil oleamide diethanolamine, myristamide diethanolamine, stearamide diethanolamine, oleamide diethanolamine, tallow amine diethanolamine, lauryl alcohol monoisopropanolamine, tallow amine monoethanolamine, isostearamide diethanolamine, isostearamide diethanolamine, isostearamide diethanolamine, isostearamide monoethanolamine).

[0054] Preferably, the aqueous personal care wash-off formulation of the present invention comprises 0.1% to 30% by weight (preferably 0.5% to 25% by weight; more preferably 0.6% to 20% by weight; most preferably 1% to 15% by weight) of an alkyl polysaccharide thickener based on the weight of the aqueous personal care wash-off formulation, wherein the alkyl polysaccharide thickener comprises 50% to 100% by weight (preferably 75% to 100% by weight; more preferably 80% to 100% by weight; still more preferably 90% to 100% by weight; still more preferably 95% to 100% by weight; still even more preferably 98% to 100% by weight; still even more preferably 99% to 100% by weight; most preferably 100% by weight) of a linear alkyl polysaccharide of formula A based on the weight of the alkyl polysaccharide thickener.

[0055] RO-(S) n H(A)

[0056] Where R is a straight chain C 9-15 alkyl group (preferably, C 9-14 Alkyl groups; more preferably, C 9-13 Alkyl group; most preferably, C 10-12Alkyl groups); wherein g is an average of 1 to 2.5 (preferably 1.1 to 2; more preferably 1.1 to 1.75; most preferably 1.15 to 1.5), and wherein S is a monosaccharide selected from the group consisting of ribulose, xylulose, ribose, arabinose, xylose, lysose, and mixtures thereof (preferably arabinose, xylose, and mixtures thereof; most preferably xylose); and wherein the monosaccharide S in the linear alkyl polysaccharide of formula A is 70% to 100% by weight (preferably 80% to 100% by weight; more preferably 85% to 10% by weight). 0% by weight; more preferably, 90% by weight to 100% by weight; even more preferably, 95% by weight to 100% by weight; still more preferably, 98% by weight to 100% by weight; most preferably, 99% by weight to 100% by weight) is xylose; provided that the alkyl polysaccharide thickener contains <15% by weight (preferably, <10% by weight; more preferably, <1% by weight; still more preferably, <0.1% by weight; even more preferably, 0.01% by weight; still more preferably, 0.001% by weight; most preferably, less than the detectable limit) of a branched alkyl polysaccharide of Formula I based on the weight of the alkyl polysaccharide thickener.

[0057] (I)

[0058] Where R 1 Is it a straight chain or a branched chain C? 3-4 alkyl groups; wherein R 2 Is it a straight chain or a branched chain C? 5-6 alkyl groups; wherein G 1 It is a monosaccharide having 4 to 6 carbon atoms and wherein x is 1.1 to 4; and the prerequisite is that the alkyl polysaccharide thickener contains <1.5% by weight (preferably, <1% by weight; more preferably, <0.5% by weight; still more preferably, <0.1% by weight; even more preferably, <0.01% by weight; still even more preferably, <0.001% by weight; still even more preferably, <0.0001% by weight; most preferably, less than the detectable limit) of a branched alkyl polysaccharide of Formula II.

[0059] R 3 -(OG 2 ) y (II)

[0060] Where R 3 It is an alkyl or alkenyl moiety containing 7 to 30 carbon atoms, wherein the alkyl or alkenyl moiety is in R 3 A branch is formed at a carbon position of 2 or higher, wherein the branch is selected from the group consisting of: methyl, ethyl, isopropyl, n-propyl, butyl, pentyl, hexyl, and mixtures thereof; wherein G 2It is a sugar fraction selected from the group consisting of: glucose, fructose, mannose, galactose, tarose, gulose, allose, azoose, idose, arabinose, xylose, lysoose, ribose, and mixtures thereof, wherein y is an average of ≥2 (preferably 2 to 10).

[0061] Preferably, the aqueous personal care wash-off formulation of the present invention comprises 0.1% to 30% by weight (preferably 0.5% to 25% by weight; more preferably 0.6% to 20% by weight; most preferably 1% to 15% by weight) of an alkyl polysaccharide thickener based on the weight of the aqueous personal care wash-off formulation, wherein the alkyl polysaccharide thickener comprises 50% to 100% by weight (preferably 75% to 100% by weight; more preferably 80% to 100% by weight; still more preferably 90% to 100% by weight; still more preferably 95% to 100% by weight; still even more preferably 98% to 100% by weight; still even more preferably 99% to 100% by weight; most preferably 100% by weight) of a linear alkyl polysaccharide of formula A based on the weight of the alkyl polysaccharide thickener.

[0062] RO-(S) n H(A)

[0063] Where R is a straight chain C 9-15 alkyl group (preferably, C 9-14 Alkyl groups; more preferably, C 9-13 Alkyl group; most preferably, C 10-12 Alkyl groups); wherein g is an average of 1 to 2.5 (preferably 1.1 to 2; more preferably 1.1 to 1.75; most preferably 1.15 to 1.5), and wherein S is a monosaccharide selected from the group consisting of ribulose, xylulose, ribose, arabinose, xylose, lysose, and mixtures thereof (preferably arabinose, xylose, and mixtures thereof; most preferably xylose); and wherein the monosaccharide S in the linear alkyl polysaccharide of formula A is 70% to 100% by weight (preferably 80% to 100% by weight; more preferably 85% to 10% by weight). 0% by weight; more preferably, 90% by weight to 100% by weight; even more preferably, 95% by weight to 100% by weight; still more preferably, 98% by weight to 100% by weight; most preferably, 99% by weight to 100% by weight) is xylose; provided that the alkyl polysaccharide thickener contains <15% by weight (preferably, <10% by weight; more preferably, <1% by weight; still more preferably, <0.1% by weight; even more preferably, 0.01% by weight; still more preferably, 0.001% by weight; most preferably, less than the detectable limit) of a branched alkyl polysaccharide of Formula I based on the weight of the alkyl polysaccharide thickener.

[0064] (I)

[0065] Where R 1 Is it a straight chain or a branched chain C? 3-4 alkyl groups; wherein R 2 Is it a straight chain or a branched chain C? 5-6 alkyl groups; wherein G 1 It is a monosaccharide having 4 to 6 carbon atoms and wherein x is 1.1 to 4; provided that the alkyl polysaccharide thickener contains <1.5% by weight (preferably, <1% by weight; more preferably, <0.5% by weight; still more preferably, <0.1% by weight; even more preferably, <0.01% by weight; still even more preferably, <0.001% by weight; still even more preferably, <0.0001% by weight; most preferably, less than the detectable limit) of a branched alkyl polysaccharide of Formula II.

[0066] R 3 -(OG 2 ) y (II)

[0067] Where R 3 It is an alkyl or alkenyl moiety containing 7 to 30 carbon atoms, wherein the alkyl or alkenyl moiety is in R 3 A branch is formed at a carbon position of 2 or higher, wherein the branch is selected from the group consisting of: methyl, ethyl, isopropyl, n-propyl, butyl, pentyl, hexyl, and mixtures thereof; wherein G 2 It is a sugar fraction selected from the group consisting of: glucose, fructose, mannose, galactose, tarose, gulose, allose, azoose, idose, arabinose, xylose, lysoose, ribose, and mixtures thereof, wherein y is an average of ≥2 (preferably, 2 to 10); and has any one or more of the following additional preconditions (i) to (x), namely: (i) the precondition is that the alkyl polysaccharide thickener contains <1% by weight (preferably, <0.5% by weight; more preferably, <0.1% by weight; still more preferably, <0.01% by weight; even more preferably, <0.001% by weight; still even more preferably, <0.0001% by weight; most preferably, less than the detectable limit) of a branched alkyl polysaccharide of Formula III based on the weight of the alkyl polysaccharide thickener.

[0068] R 4 -O-(G 3 ) p H(III)

[0069] Where R 4 It is a branch C 8-15 alkyl groups; wherein G 3(i) is a monosaccharide having 5 or 6 carbon atoms and wherein p is an average of 1 to 10; (ii) provided that the alkyl polysaccharide thickener contains <10% by weight (preferably, <1% by weight; more preferably, <0.1% by weight; still more preferably, <0.01% by weight; even more preferably, <0.001% by weight; still even more preferably, <0.0001% by weight; still even more preferably, <0.00001% by weight; most preferably, less than the detectable limit) of a branched alkyl polysaccharide of formula IV.

[0070] (IV)

[0071] Where R 5 It is –(CH2) r CH(CH3)2; where R 6 It is –(CH2) r+2 CH(CH3)2;G 4 It is a monosaccharide having 4 to 6 carbon atoms; wherein m is 1.1 to 4 and r is 0 to 3; (iii) the prerequisite is that the alkyl polysaccharide thickener contains <1.5% by weight (preferably, <1% by weight; more preferably, <0.1% by weight; still more preferably, <0.01% by weight; even more preferably, <0.001% by weight; still even more preferably, <0.0001% by weight; still even more preferably, <0.00001% by weight; most preferably, less than the detectable limit) of a branched alkyl polysaccharide of formula V based on the weight of the alkyl polysaccharide thickener.

[0072] (V)

[0073] Where R 7 It is –(CH2) b CH(CH3)2; where R 8 It is –CH2-CH(CH3)(CH2) b+1 CH3; G 5 It is a monosaccharide having 4 to 6 carbon atoms; wherein a is 1.1 to 4 and wherein b is 0 to 3; (iv) provided that the alkyl polysaccharide thickener contains <0.5% by weight (preferably, <0.1% by weight; more preferably, <0.05% by weight; still more preferably, <0.01% by weight; even more preferably, <0.001% by weight; still even more preferably, <0.0001% by weight; still even more preferably, <0.00001% by weight; most preferably, less than the detectable limit) of a branched alkyl polysaccharide of formula VI based on the weight of the alkyl polysaccharide thickener.

[0074] (VI)

[0075] Where R 9It is –(CH2) d+1 CH3; where R 10 It is –(CH2) d+3 CH3; where G 6 It is a monosaccharide having 4 to 6 carbon atoms; wherein d is 0 to 3 and wherein c is 1.1 to 4; (v) the prerequisite is that the alkyl polysaccharide thickener contains <0.05% by weight (preferably, <0.01% by weight; more preferably, <0.005% by weight; still more preferably, <0.001% by weight; even more preferably, <0.0001% by weight; still even more preferably, <0.00001% by weight; most preferably, less than the detectable limit) of a compound of formula VII based on the weight of the alkyl polysaccharide thickener.

[0076] (VII)

[0077] Where R 11 Is it hydrogen or straight-chain or branched C? 1-4 alkyl groups; wherein R 12 It is -CH2CH2R 11 Group; wherein G 7 It is glucose or xylose, wherein the amount of glucose ranges from 70 mol% to 95 mol%, and the amount of xylose ranges from 5 mol% to 30 mol%, and wherein f is 1.1-4; (vi) the prerequisite is that the alkyl polysaccharide thickener contains <5% by weight (preferably, <1% by weight; more preferably, <0.5% by weight; still more preferably, <0.1% by weight; even more preferably, <0.01% by weight; still even more preferably, <0.001% by weight; still even more preferably, <0.0001% by weight; most preferably, less than the detectable limit) of a branched alkyl polysaccharide of formula VIII based on the weight of the alkyl polysaccharide thickener.

[0078] (VIII)

[0079] Where R 13 It is –(CH2) k CH3; where R 14 It is –(CH2) k+2 CH3; where G 8 It is a monosaccharide having 4 to 6 carbon atoms; wherein h is 1.1 to 10 and wherein k is 1 to 4; (vii) provided that the alkyl polysaccharide thickener contains <1% by weight (preferably, <0.5% by weight; more preferably, <0.1% by weight; still more preferably, <0.05% by weight; even more preferably, <0.01% by weight; still even more preferably, <0.001% by weight; still even more preferably, <0.0001% by weight; most preferably, less than the detectable limit) of a branched alkyl polysaccharide of formula IX.

[0080] (IX)

[0081] Where R 15 It is -(CH2) t CH3; where R 16 It is -(CH2) t+1 CH(CH3)2; where G 9 It is a monosaccharide having 4 to 6 carbon atoms; wherein s is 1.1 to 10 and wherein t is 1 to 4; (viii) the prerequisite is that the alkyl polysaccharide thickener contains <0.2% by weight (preferably, <0.1% by weight; more preferably, <0.05% by weight; still more preferably, <0.01% by weight; even more preferably, <0.001% by weight; still even more preferably, <0.0001% by weight; still even more preferably, <0.00001% by weight; most preferably, less than the detectable limit) of a branched alkyl polysaccharide of formula X based on the weight of the alkyl polysaccharide thickener.

[0082] (X)

[0083] Where R 17 It is –(CH2) v+1 CH(CH3)2; where R 18 It is –(CH2) v-1 CH(CH3)2; where G 10 It is a monosaccharide having 4 to 6 carbon atoms; wherein u is 1.1 to 10 and v is 1 to 4; (ix) the prerequisite is that when the alkyl polysaccharide thickener contains fatty acid ester C 12-23 Alkyl-(O)O- moiety and fatty acid ester C 6-10 When both alkyl-(O)O- and alkyl-(O)O- are present, C 12-23 Alkyl-(O)O- moiety with C 6-10 The molar ratio of the alkyl-(O)O- moiety is >1.1:1 (preferably, >1.2:1; more preferably, >1.3:1; still more preferably, >1.5:1; most preferably, >2:1); and / or (x) is provided that the alkyl polysaccharide thickener contains <0.1% by weight (preferably, <0.05% by weight; more preferably, <0.01% by weight; still more preferably, <0.001% by weight; even more preferably, <0.0001% by weight; still even more preferably, <0.00001% by weight; most preferably, less than the detectable limit) of a linear alkyl polysaccharide of formula XIII.

[0084] R 23 -O-(G 12 ) i H(XIII)

[0085] Where R 23 It is a straight chain C 1-8 alkyl groups; wherein G 12 It is a monosaccharide with 5 or 6 carbon atoms, where i is an average value from 1 to 10.

[0086] Preferably, the aqueous personal care wash-off formulation of the present invention further comprises at least one ingredient selected from the group consisting of: absorbents; aesthetic enhancers (e.g., starch); α-hydroxy acids; anti-aging agents; anti-dandruff agents; antifungal agents; antimicrobial agents; antioxidants (e.g., butylated hydroxytoluene); antibacterial agents; antistatic agents; bioactive agents; bleaching agents; chelating agents; colorants; conditioning agents (e.g., silicones, polyquaternium salts, cationic guar gum); dyes; emollients; emulsifiers; film-forming agents (e.g., waterproofing agents); fixative polymers; foaming agents; fragrances; hard particles; moisturizers (e.g., glycerin, sorbitol, monoglycerides, lecithin, glycolipids). Fatty alcohols, fatty acids, polysaccharides, sorbitol esters, polysorbates (e.g., polysorbate 20, polysorbate 40, polysorbate 60 and polysorbate 80), glycols (e.g. propylene glycol), glycol analogs, triols, triol analogs, cationic polymer polyols); lubricants; opacifiers; pearlescent agents; penetrants; pH adjusters; pigments; plant extracts; preservatives (e.g. benzoic acid, sorbic acid, phenoxyethanol); proteins / amino acids; rheology modifiers; salts (e.g., NaCl); sensory modifiers; slip agents; soaps; soft particles; sunscreen additives; suspending agents; UV inhibitors; vitamins and mixtures thereof.

[0087] Preferably, the aqueous personal care wash-off formulation of the present invention further comprises 0% to 10% by weight (preferably 0% to 3% by weight) of a salt (e.g., NaCl) based on the weight of the aqueous personal care wash-off formulation.

[0088] Preferably, the aqueous personal care wash-off formulation of the present invention further comprises an antimicrobial agent. More preferably, the aqueous personal care wash-off formulation of the present invention further comprises an antimicrobial agent; wherein the antimicrobial agent is selected from the group consisting of phenoxyethanol, benzoic acid, benzyl alcohol, sodium benzoate, DMDM ​​hydantoin, 2-ethylhexylglycerin ether, and isothiazolinones (e.g., methylchloroisothiazolinone, methylisothiazolinone). Still more preferably, the aqueous personal care wash-off formulation of the present invention further comprises an antimicrobial agent; wherein the antimicrobial agent is an isothiazolinone (more preferably, wherein the antimicrobial agent is selected from the group consisting of methylisothiazolinone, methylchloroisothiazolinone, and mixtures thereof; most preferably, wherein the biocide is methylisothiazolinone).

[0089] Preferably, the aqueous personal care wash-off formulation of the present invention further comprises a pH adjuster. More preferably, the aqueous personal care wash-off formulation of the present invention further comprises a pH adjuster. Most preferably, the aqueous personal care wash-off formulation of the present invention further comprises a pH adjuster; wherein the pH of the aqueous personal care wash-off formulation is 4.5 to 9 (preferably 5 to 8; most preferably 5 to 7).

[0090] Preferably, the pH adjuster is selected from the group consisting of at least one of the following: citric acid, lactic acid, hydrochloric acid, aminoethylpropylene glycol, triethanolamine, monoethanolamine, sodium hydroxide, potassium hydroxide, and amino-2-methyl-1-propanol. More preferably, the pH adjuster is selected from the group consisting of at least one of the following: citric acid, lactic acid, sodium hydroxide, potassium hydroxide, triethanolamine, and amino-2-methyl-1-propanol. Still more preferably, the pH adjuster includes triethanolamine. Most preferably, the pH adjuster is triethanolamine.

[0091] Preferably, the aqueous personal care wash-off formulation has a viscosity ≥ 2,000 cP at 21°C (preferably 2,000 cP to 50,000 cP at 21°C; more preferably 2,500 cP to 30,000 cP at 21°C; even more preferably 3,000 cP to 25,000 cP at 21°C; even more preferably 4,000 cP to 20,000 cP at 21°C; most preferably 5,000 cP to 15,000 cP at 21°C) (preferably measured after 24 hours in a temperature-controlled room (21°C ± 3°C) using a Brookfield viscometer model DV-II+ at 30 RPM with RV spindle 31). The viscosity value can be obtained after a stabilization time of 1 minute.

[0092] Preferably, the aqueous personal care wash-off formulation comprises <0.05% by weight (preferably <0.01% by weight; more preferably <0.005% by weight; still more preferably <0.001% by weight; even more preferably <0.0005% by weight; still even more preferably <0.0001% by weight; most preferably, below the detectable limit) of a branched alkyl polysaccharide of formula IV based on the weight of the aqueous personal care wash-off formulation.

[0093] (IV)

[0094] Where R 5 It is –(CH2) r CH(CH3)2; where R 6 It is –(CH2) r+2 CH(CH3)2;G 4It is a monosaccharide having 4 to 6 carbon atoms; where m is 1.1 to 4 and r is 0 to 3.

[0095] Preferably, the aqueous personal care wash-off formulation comprises <0.1% by weight (preferably <0.01% by weight; more preferably <0.001% by weight; still more preferably <0.0001% by weight; even more preferably <0.00001% by weight; most preferably, below the detectable limit) of a branched alkyl polysaccharide according to Formula XI based on the weight of the aqueous personal care wash-off formulation.

[0096] (XI)

[0097] Where R 19 It is C 2-4 alkyl groups; wherein R 20 It is C 4-7 alkyl groups; wherein R 19 and R 20 The sum of carbon atoms in G is between 7 and 11; where G 11 It is a monosaccharide (i.e., glucose, mannose, galactose, tarose, allose, azoose, idose, arabinose, xylose, ribose, lysoose, and mixtures thereof), and wherein w is 1 to 4.

[0098] Preferably, the aqueous personal care wash-off formulation comprises <0.05% by weight (preferably <0.01% by weight; more preferably <0.005% by weight; still more preferably <0.001% by weight; even more preferably <0.0005% by weight; and most preferably, less than the detectable limit) of a fatty acid alkyl ester alkoxylate based on the weight of the aqueous personal care wash-off formulation.

[0099] R 21 CO2-(AO) e -R 22 (XII)

[0100] Where R 21 It is a straight-chain or branched, saturated or unsaturated alkyl group containing 5 to 21 carbon atoms; wherein AO is C 2-4 Epoxyalkane group; wherein e is 1 to 30, and wherein R 22 It is a straight-chain or branched alkyl group containing 1 to 6 carbon atoms.

[0101] Preferably, the aqueous personal care wash-off formulation comprises <0.01% by weight (preferably <0.005% by weight; more preferably <0.001% by weight; still more preferably <0.0001% by weight; even more preferably <0.00001% by weight; most preferably, less than the detectable limit) of an alkyl polyglucan (e.g., C10) based on the weight of the aqueous personal care wash-off formulation. 1-30 Alkyl polyglucoside).

[0102] Preferably, the aqueous personal care wash-off formulation contains <0.1% by weight (preferably <0.05% by weight; more preferably <0.01% by weight; still more preferably <0.001% by weight; even more preferably <0.0001% by weight; most preferably, less than the detectable limit) of C based on the weight of the aqueous personal care wash-off formulation. 6-24 Alkyl polyglucosides (e.g., polyglucosides).

[0103] Preferably, the aqueous personal care wash-off formulation comprises <0.01% by weight (preferably <0.005% by weight; more preferably <0.001% by weight; still more preferably <0.0001% by weight; even more preferably <0.00001% by weight; most preferably, less than the detectable limit) of fatty acid ester C based on the weight of the aqueous personal care wash-off formulation. 12-23 Alkyl-(O)O-parts and / or fatty acid esters C 6-10 Alkyl polysaccharide thickeners with alkyl-(O)O- moiety.

[0104] Preferably, the method of cleaning at least one of mammalian skin and hair (preferably, at least one of human skin and hair) according to the present invention comprises: applying the aqueous personal care wash-off formulation of the present invention to mammalian skin or hair (preferably, human skin or hair); and rinsing the aqueous personal care wash-off formulation off the skin or hair with rinsing water.

[0105] Some embodiments of the present invention will now be described in detail in the following examples.

[0106] Synthesis of S1 to S10: Alkyl polysaccharides

[0107] A 500 mL round-bottom reactor was placed in an aluminum heating block and equipped with a 25 mL ean-Stark separator (containing 15 mL hexane) and a magnetic stir bar. Sugar (Ag, 200 mmol) and n-butanol (B mL, 1.2 mol, 6 equivalents) were added to the reactor as shown in Table 1. The reactor contents were then vigorously stirred under nitrogen cover (bubbling). p-Toluenesulfonic acid monohydrate (C mg, 2.00 mmol, 1 mol%) (as noted in Table 1) was added to the stirred reactor contents, and the aluminum heating block was set to temperature T. 1 The contents were then set at the specified temperature (as indicated in Table 1) and maintained at that temperature for 2 hours. The reactor contents were then cooled to ambient temperature with continuous stirring. An alcohol (D, 600 mmol, 3 equivalents) was then added to the reactor contents. The type and amount of alcohol added are reported in Table 1. The Dean-Stark separator was then reassembled with a distillation head and condenser flask. The reactor contents were then vacuum distilled, with the aluminum heating block set at temperature T. 2 (As shown in Table 1) and set the condenser flask in an ice-cooled bath. Periodically adjust the vacuum to a flow rate of 1-2 drops / second. Maintain the vacuum for 2 hours. Then stop distillation. Return the distillation apparatus to a nitrogen atmosphere and allow the contents of the stirred reactor to cool to ambient temperature. Add sodium hydroxide solution (120 μL, 50% by weight aqueous solution, 2.2 mmol) to the stirred reactor contents. After vigorous stirring, measure the pH (pH paper) to ensure the reactor contents are alkaline. Dilute a 30 mL sample of the reactor contents with hexane (30 mL) and purify by automated column chromatography (silica gel, 220 g). The alcohol was eluted at 20 / 80 ethyl acetate / hexane. The solvent mixture was then increased to 100% ethyl acetate over 2 column volumes. The solvent system was then changed to ethyl acetate-methanol, and the solvent ratio was increased to net methanol over 6 column volumes—during which time the product eluted as a mixture of monosaccharides and polysaccharides. The solvent was removed under reduced pressure to obtain the final product.

[0108] Table 1

[0109]

[0110] Comparative Examples CF1 to CF5 and Examples F1 to F5: Aqueous Formulations

[0111] Aqueous surfactant formulations having the compositions of Comparative Examples CF1 to CF5 and Examples F1 to F5 as shown in Table 2 were prepared.

[0112] Table 2

[0113]

[0114] Thickening properties

[0115] The thickening properties of the alkyl polysaccharides synthesized in S1 to S4 and S6 to S10 were evaluated by measuring the viscosity of the aqueous surfactant formulations prepared according to Comparative Examples CF1 to CF5 and Examples F1 to F5. The viscosities reported in Table 3 were measured using the Total Aspiration and Dispensing Monitoring (TADM) function on a Hamilton MicroLab Star liquid handling robot at 21°C. Hamilton aspirated and dispensed the samples at a set rate and monitored pressure changes (Δp). Calibration curves were generated using known viscosity standards. The viscosity was calculated by comparing the pressure curve of the samples with the pressure curve of the viscosity standards. The data collected by the TADM method are Δp values ​​in Pascals (Pa). The viscosity was calculated from the measured Δp according to the following formula: Viscosity = 0.3461 × Δp - 115.44.

[0116] Table 3

[0117]

[0118] Comparative Examples CF6 to CF8 and Example F6: Aqueous Surfactant Formulations

[0119] Aqueous surfactant formulations having the compositions of comparative examples CF6 to CF8 and example F6 as shown in Table 4 were prepared.

[0120] Table 4

[0121]

[0122] Thickening properties

[0123] The viscosity of the aqueous surfactant formulations prepared according to Comparative Examples CF6 to CF8 and Example F6 was measured to evaluate the effect of short-chain (C8 alkyl) alkyl polysaccharides (synthetic S5) on longer-chain (C8 alkyl) alkyl polysaccharides. 10 / C 12The effect of blends of alkyl polysaccharides (synthetic S7 and synthetic S9). Viscosities reported in Table 5 were measured using the Total Aspiration and Dispensing Monitoring (TADM) function on a Hamilton MicroLab Star liquid handling robot at 21 °C. Hamilton aspirated and dispensed samples at a set rate and monitored pressure changes (Δp). Calibration curves were generated using known viscosity standards. Viscosities were calculated by comparing the pressure curves of the samples with those of the viscosity standards. Data collected using the TADM method are Δp values ​​in Pascals (Pa). Viscosity was calculated from the measured Δp using the following formula: Viscosity = 0.3461 × Δp - 115.44.

[0124] Table 5

[0125]

[0126] Comparative Examples CF9 to CF11 and Examples F7 to F8: Aqueous Formulations

[0127] Aqueous surfactant formulations having the compositions of Comparative Examples CF9 to CF11 and Examples F7 to F8 as shown in Table 6 were prepared.

[0128] Table 6

[0129]

[0130] Thickening properties

[0131] By using C according to comparative examples CF9 to CF11 10 The measured viscosity of the aqueous surfactant formulation prepared from alkyl polyglucosides was compared with that obtained using C according to Examples F7 to F8. 10 A comparison of the measured viscosities of aqueous surfactant formulations prepared from alkyl xylosides demonstrated that C 10 Alkyl polyxyloside ratio C 10 Alkyl polyglucosides exhibit superior thickening properties. Viscosities reported in Table 7 were measured using the Total Aspiration and Dispensing Monitoring (TADM) function on a Hamilton MicroLab Star liquid handling robot at 21°C. Hamilton aspirated and dispensed the sample at a set rate, monitoring pressure changes (Δp). Calibration curves were generated using known viscosity standards. Viscosities were calculated by comparing the pressure curves of the sample with those of the viscosity standards. Data collected using the TADM method are Δp values ​​in Pascals (Pa). Viscosity was calculated from the measured Δp using the following formula: Viscosity = 0.3461 × Δp - 115.44.

[0132] Table 7

[0133]

Claims

1. A water-based personal care wash-off formulation, wherein the water-based personal care wash-off formulation comprises: Aqueous carton that is dermatologically acceptable; Dermatologically acceptable cleansing surfactants, wherein the dermatologically acceptable cleansing surfactants comprise anionic surfactants; and Alkyl polysaccharide thickener, wherein the alkyl polysaccharide thickener comprises 50% to 100% by weight of a linear alkyl polysaccharide of formula A based on the weight of the alkyl polysaccharide thickener. R-O-(S) n H(A) Where R is a straight chain C 9-15 Alkyl group; wherein n is an average value of 1 to 2.5, and wherein S is a monosaccharide selected from the group consisting of ribulose, xylulose, ribose, arabinose, xylose, lysoose and mixtures thereof; and wherein 70% to 100% by weight of the monosaccharide S in the linear alkyl polysaccharide of formula A is xylose; The prerequisite is that the alkyl polysaccharide thickener contains <15% by weight of a branched alkyl polysaccharide of Formula I based on the weight of the alkyl polysaccharide thickener. (I) Where R 1 Is it a straight chain or a branched chain C? 3-4 alkyl groups; wherein R 2 Is it a straight chain or a branched chain C? 5-6 alkyl groups; wherein G 1 It is a monosaccharide having 4 to 6 carbon atoms, where x is 1.1 to 4; and The prerequisite is that the alkyl polysaccharide thickener contains <1.5% by weight of a branched alkyl polysaccharide of Formula II based on the weight of the alkyl polysaccharide thickener. R 3 -(AND 2 ) y (II) Where R 3 It is an alkyl or alkenyl moiety containing 7 to 30 carbon atoms, wherein the alkyl or alkenyl moiety is in R 3 A branch is formed at a carbon position of 2 or higher, wherein the branch is selected from the group consisting of: methyl, ethyl, isopropyl, n-propyl, butyl, pentyl, hexyl, and mixtures thereof; wherein G 2 y is the sugar fraction selected from the group consisting of: glucose, fructose, mannose, galactose, tarose, gulose, allose, azoose, idose, arabinose, xylose, lysoose, ribose, and mixtures thereof, where y is the average of ≥2.

2. The aqueous personal care wash-off formulation according to claim 1, wherein the anionic surfactant is selected from the group consisting of glycine salts, taurine salts, glutamate salts, sarcosine salts, hydroxyethyl sulfonate salts, sulfoacetate salts, alanine salts, sulfates, sulfonates, succinates, carboxylates, and mixtures thereof.

3. The aqueous personal care wash-off formulation of claim 2, wherein the dermatologically acceptable cleansing surfactant further comprises an amphoteric surfactant.

4. The aqueous personal care wash-off formulation according to claim 3, wherein the amphoteric surfactant is selected from the group consisting of: betaine, amphoteric acetate, sulfobetaine, and mixtures thereof.

5. The aqueous personal care wash-off formulation according to claim 4, wherein the anionic surfactant comprises sodium lauryl ether sulfate, and the amphoteric surfactant comprises cocamidopropyl betaine.

6. The aqueous personal care wash-off formulation according to claim 5, wherein R is a linear C 10-12 Alkyl groups.

7. The aqueous personal care wash-off formulation according to claim 1, wherein the aqueous personal care wash-off formulation has a viscosity ≥1,500 cP at 21°C.

8. The aqueous personal care wash-off formulation according to claim 7, further comprising ingredients selected from the group consisting of: absorbents, aesthetic enhancers, alpha-hydroxy acids, anti-aging agents, anti-dandruff agents, antifungal agents, antimicrobial agents, antioxidants, antibacterial agents, antistatic agents, bioactive agents, bleaching agents, chelating agents, colorants, conditioning agents, dyes, emollients, emulsifiers, film-forming agents, fixative polymers, foaming agents, fragrances, hard particles, moisturizers, lubricants, sunscreens, pearlescent agents, penetrants, pH adjusters, pigments, plant extracts, preservatives, proteins / amino acids, rheology modifiers, salts, sensory modifiers, slip agents, soft particles, sunscreen additives, suspending agents, UV inhibitors, vitamins, and mixtures thereof.

9. The water-based personal care wash-off formulation according to claim 8, wherein the water-based personal care wash-off formulation is selected from the group consisting of: shampoos, conditioning shampoos, shower gel formulations, exfoliating shower gel formulations, facial cleansers, exfoliating facial cleansers, liquid hand soap formulations, and mild cleansing formulations.

10. A method for cleaning at least one of mammalian skin and hair, the method comprising: Apply the aqueous personal care wash-off formulation according to claim 1 to the skin or hair of a mammal; as well as Rinse the water-based personal care wash-off preparation off the skin or hair with rinsing water.

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