Mixing device for processing amlodipine benazepril capsules and processing technology

Abstract

The invention relates to the technical field of capsule production, and discloses a mixing device for amlodipine benazepril capsule processing and a processing technology.The mixing device for amlodipine benazepril capsule processing comprises a bottom frame, a driving assembly and a mixing assembly, the driving assembly and the mixing assembly are arranged above the bottom frame, and a flow guide mechanism is arranged in the mixing assembly; a lifting mechanism is arranged between the flow guide mechanism and the driving assembly, through the arranged overturning assembly, in the rotating process of the V-shaped charging barrel, the unique shape of the V-shaped charging barrel enables materials to continuously roll and collide in the barrel, the contact opportunity between the materials is increased, meanwhile, a first overturning plate and a second overturning plate are opened and closed under the action of gravity, and therefore the materials are not prone to falling off. And the flow guide plate and the V-shaped flow guide plate jointly guide capsule powder, so that the movement path of materials in the barrel is changed, the materials are fully blended, the shearing force and convection are increased, material agglomeration is broken, and the effects of improving the mixing efficiency and the mixing uniformity are achieved.

Description

Technical Field

[0001] This invention relates to the field of capsule manufacturing technology, and in particular to a mixing device and processing technology for processing amlodipine and benazepril capsules. Background Technology

[0002] In the processing of amlodipine and benazepril capsules, the mixing process is crucial to drug quality. Currently, V-shaped mixers are commonly used equipment. However, existing V-shaped mixers have certain limitations. During the mixing process, materials are prone to localized aggregation, making it difficult to achieve uniform mixing and resulting in uneven proportions of drug components within the capsules. Furthermore, their simple flow guide design leads to a single material movement trajectory and low mixing efficiency. Simultaneously, the lack of a mechanism for flexible adjustment of the mixing space fails to adequately meet the needs of different production scales, impacting the overall quality of the capsules and production efficiency.

[0003] Patent publication number CN212237002U discloses a mixing device for capsule production, including a frame. A shaft frame is welded to the top outer wall of the frame, and a fixed shaft is connected to the inner wall of the shaft frame via bearings. A V-shaped mixing tank is fixedly connected between the two fixed shafts. A discharge hopper is welded to the bottom outer wall of the V-shaped mixing tank. A tank cover fixing structure is provided on both sides of the top outer wall of the V-shaped mixing tank. One of the frames is bolted to a drive motor and a reducer. The V-shaped mixing tank includes a V-shaped tank body, a heat-insulating sleeve, an electric heating baffle, and a stirring assembly. This patent describes a V-shaped mixing tank that utilizes high-speed operation, combined with internal electric heating baffles for heat insulation. The stirring assembly is located on both sides of the tank body and conforms to the V-shaped tank structure. Through staggered stirring, the raw materials are mixed evenly. Molten raw materials form turbulent flows on both sides of the V-shaped tank body, ensuring thorough mixing.

[0004] The existing technology has the following drawbacks:

[0005] Insufficient mixing uniformity: Existing devices use a simple mixing method that fails to generate sufficient shear force and convection, making it difficult to break up material agglomerates. Furthermore, the material's movement path within the drum is singular, hindering thorough mixing. While using an additional stirring rod can increase shear force and convection, breaking up agglomerates, the strong stirring can damage the material's original physical properties, such as causing particle breakage and altering crystal structure. Therefore, an adjustable flow guiding structure and a sealing mechanism are needed. The flow guiding structure can dynamically change the material's movement path within the drum, ensuring thorough mixing, increasing shear force and convection, breaking up agglomerates, and improving mixing uniformity. The sealing mechanism can reduce the space, concentrating the material in a smaller area for mixing, reducing dispersion and improving mixing efficiency and uniformity.

[0006] The inability to adjust the center of gravity of the mixing drum: Existing devices cannot adjust the center of gravity of the mixing drum, making it difficult for materials to tumble and convection fully within the drum. For example, denser materials tend to concentrate at the bottom of the mixing drum, while less dense materials remain at the top, resulting in uneven distribution of drug components. Simultaneously, due to the fixed center of gravity, material flow is restricted in certain areas within the mixing drum, creating mixing dead zones. In these dead zones, materials hardly participate in the mixing process, resulting in insufficiently mixed portions in the final product. Therefore, a structure that allows for adjusting the center of gravity of the mixing drum is needed to ensure even distribution of materials of different densities, preventing denser materials from sinking to the bottom and less dense materials from floating to the top. This would also eliminate mixing dead zones, allowing materials in previously restricted flow areas to actively participate in the mixing process, thereby improving the mixing quality. Summary of the Invention

[0007] In view of the problems of insufficient mixing uniformity and inability to adjust the center of gravity of the mixing cylinder in the existing technology, a mixing device and processing technology for processing amlodipine and benazepril capsules are proposed.

[0008] One aspect of this application provides a mixing device for processing amlodipine and benazepril capsules. Its purpose is to: dynamically change the movement path of materials within the cylinder through a flow guiding mechanism, allowing for thorough mixing, increasing shear force and convection, breaking up material agglomeration, and improving mixing uniformity; and to periodically reduce the space, concentrating materials in a smaller area for mixing, reducing dispersion of movement; simultaneously, through a lifting mechanism, materials of different densities can be evenly distributed, preventing denser materials from sinking and less dense materials from floating, eliminating mixing dead zones, and allowing materials in originally restricted flow areas to actively participate in mixing, thereby improving mixing efficiency and mixing uniformity.

[0009] The technical solution of the present invention is: a mixing device for processing amlodipine and benazepril capsules, comprising a base frame, a driving component and a mixing component disposed above the base frame, wherein a flow guiding mechanism is disposed inside the mixing component, and a lifting mechanism is disposed between the flow guiding mechanism and the driving component;

[0010] The mixing component includes a support frame installed inside the drive component, and a V-shaped material cylinder is fixedly connected to the inner wall of the support frame. The flow guiding mechanism includes a closing component and a flipping component disposed on the inner wall of the V-shaped material cylinder.

[0011] The flipping assembly includes a V-shaped guide plate fixedly connected to the inner wall of the V-shaped material cylinder. Both ends of the V-shaped guide plate are fixedly installed with steering hinges. The outer walls of the two steering hinges are respectively fixedly connected with a first flipping plate and a second flipping plate. The first flipping plate and the second flipping plate can open and close under the action of gravity when the V-shaped material cylinder rotates, so as to guide the capsule powder.

[0012] Using the above scheme, the unique shape of the V-shaped barrel causes the material to tumble and collide continuously during the rotation of the V-shaped barrel, increasing the contact opportunities between materials. At the same time, the first and second flip plates open and close under the action of gravity, together with the V-shaped guide plate, to guide the capsule powder, change the material movement path, enhance the shear force and convection between materials, break up material agglomeration, and improve the mixing uniformity.

[0013] Furthermore, the sealing assembly includes a central rod rotatably connected to the inner wall of the V-shaped cylinder, a sealing plate fixedly connected to the outer wall of the central rod, one end of the central rod penetrating the V-shaped cylinder and fixedly connected to a driven wheel, and a rope nail fixedly connected to the inner wall of the driven wheel. When the sealing plate closes the V-shaped cylinder, it can reduce the space of the V-shaped cylinder.

[0014] Furthermore, the flow guiding mechanism also includes a reset frame fixedly connected to the outer wall of the V-shaped material cylinder. A weight is slidably connected to the inner wall of the reset frame. A telescopic spring is fixedly connected between the bottom of the weight and the inner wall of the reset frame. A steel wire rope is fixedly connected to the end of the weight away from the telescopic spring. The middle section of the steel wire rope is fixedly connected to a rope fixing nail. When the steel wire rope is pulled, the driven wheel is driven to rotate through the rope fixing nail.

[0015] Using the above scheme, through the set flow guiding mechanism, when the V-shaped material cylinder moves upward, the trapezoidal block pulls the wire rope. Since the middle section of the wire rope is fixedly connected to the rope fixing nail, when the wire rope is pulled, the fixed rope fixing nail drives the passive wheel to rotate, thereby causing the central rod to rotate, and the closed plate fixed to the outer wall of the central rod to flip accordingly. When the V-shaped material cylinder moves downward, the weight will pull the wire rope in the opposite direction under the rebound force of the telescopic spring, causing the passive wheel to rotate, thereby driving the closed plate to reset. Thus, the flipping of the closed plate in stages reduces the internal space of the V-shaped material cylinder, which enhances the interaction between materials. The materials are subjected to stronger compression and collision in a smaller space, further improving the mixing efficiency.

[0016] Furthermore, the drive assembly includes a bearing frame fixedly mounted on the top of the base frame, with a drive shaft rotatably connected to the inner wall of the bearing frame. The lifting mechanism includes an umbrella-shaped frame fixedly mounted on the outer wall of the drive shaft, with a trapezoidal block fixedly connected to the outer wall of the umbrella-shaped frame. The outer wall of the trapezoidal block is fixedly connected to the end of the wire rope away from the weight.

[0017] Furthermore, the inner wall of the umbrella-shaped frame is provided with a lifting groove, the inner wall of the lifting groove is slidably connected to the outer wall of the support frame, a central block is fixedly connected to the inner wall of the umbrella-shaped frame, a threaded rod is threadedly connected to the inner wall of the central block, a rotating rod is fixedly connected to the outer wall of the threaded rod, and the outer wall of the rotating rod is rotatably connected to the inner wall of the support frame.

[0018] Furthermore, the lifting mechanism also includes a connecting rod fixedly connected to the bottom of the support frame, and a synchronization component disposed at the bottom of the connecting rod. The synchronization component includes a diamond-shaped frame fixedly connected to the bottom of the connecting rod. Multiple synchronization gears are rotatably connected to the inner wall of the diamond-shaped frame. Toothed transmission belts are connected between the multiple synchronization gears. The bottom of the rotating rod is connected to the corresponding synchronization gear. A rotating cylinder is fixedly connected to the outer wall of the diamond-shaped frame. The output end of the rotating cylinder is connected to the corresponding synchronization gear.

[0019] Using the above scheme, the lifting mechanism operates the rotating cylinder, whose output end drives the corresponding synchronous gear to rotate. Multiple synchronous gears are driven by a toothed transmission belt, causing the synchronous gear connected to the bottom of the rotating rod to rotate synchronously, thereby driving the rotating rod to rotate. The rotating rod drives the threaded rod fixedly connected to it to rotate. Since the threaded rod is threadedly connected to the center block, when the threaded rod rotates, the support frame moves up and down in the lifting groove on the inner wall of the umbrella-shaped frame. The movement of the support frame drives the V-shaped material cylinder to move up and down, thereby adjusting the center of gravity position of the V-shaped material cylinder. The change in the center of gravity position makes the movement trajectory of the material more complex and variable, avoiding the stratification phenomenon of the material due to density differences, eliminating mixing dead zones, and further improving the mixing effect.

[0020] Furthermore, the drive assembly also includes a servo motor fixedly mounted on the inner wall of the base frame, and the output shaft of the servo motor is connected to the drive shaft.

[0021] Furthermore, two symmetrically arranged feed top covers are fixedly installed on the top of the V-shaped material cylinder, and a discharge valve is fixedly installed on the bottom of the V-shaped material cylinder.

[0022] The above scheme, through the servo motor, the feed top cover and the discharge valve, serves to feed materials, discharge materials and provide power.

[0023] Another aspect of this application provides a processing method for a mixing apparatus for processing amlodipine and benazepril capsules, comprising the following steps:

[0024] Step 1: Accurately weigh amlodipine, benazepril, and excipients according to the formula, and sieve to ensure uniform particle size;

[0025] Step 2: Slowly pour the pre-treated material into the V-shaped material cylinder;

[0026] Step 3: Activate the drive component to rotate the V-shaped cylinder for mixing;

[0027] Step 4: The first and second tilting plates open and close under the action of gravity, guiding the material;

[0028] Step 5: Operate the lifting mechanism to move the V-shaped cylinder up and down, adjust the center of gravity of the V-shaped cylinder, and make its movement trajectory more complex and varied;

[0029] Step Six: As the V-shaped barrel moves up and down, it causes the enclosed component to flip, gradually reducing the internal space of the V-shaped barrel and enhancing the interaction between materials.

[0030] Step 7: After mixing, discharge and package.

[0031] By adopting the above scheme, the flow guiding mechanism can dynamically change the movement path of the material in the cylinder, allowing the material to fully mix, increasing shear force and convection, breaking up material agglomeration, and improving mixing uniformity. It also reduces the space in stages, allowing the material to concentrate in a smaller area for mixing, reducing the dispersion of movement. At the same time, the lifting mechanism allows materials of different densities to be evenly distributed, avoiding the situation where denser materials sink to the bottom and less dense materials float to the top, and eliminating mixing dead zones, allowing materials in areas with restricted flow to actively participate in mixing, thereby improving mixing efficiency and mixing uniformity.

[0032] The beneficial effects of this invention are:

[0033] 1. Through the set flipping component, during the rotation of the V-shaped material cylinder, the unique shape of the V-shaped material cylinder causes the material to continuously roll and collide inside the cylinder, increasing the contact opportunities between materials. At the same time, the first flipping plate and the second flipping plate open and close under the action of gravity, together with the V-shaped guide plate, to guide the capsule powder, change the material movement path, enhance the shear force and convection between materials, break up material agglomeration, and improve the mixing uniformity.

[0034] 2. Through the designed flow guiding mechanism, when the V-shaped material cylinder moves upward, the trapezoidal block pulls the wire rope. Since the middle section of the wire rope is fixedly connected to the rope fixing nail, when the wire rope is pulled, the fixed rope fixing nail drives the driven wheel to rotate, which in turn causes the central rod to rotate. The closing plate fixed to the outer wall of the central rod then flips over. When the V-shaped material cylinder moves downward, the weight will pull the wire rope in the opposite direction under the rebound force of the telescopic spring, causing the driven wheel to rotate again, thereby driving the closing plate to reset. Thus, the flipping of the closing plate in stages reduces the internal space of the V-shaped material cylinder, which enhances the interaction between materials. The materials are subjected to stronger compression and collision in a smaller space, further improving the mixing efficiency.

[0035] 3. Through the set lifting mechanism, the rotating cylinder is operated, and its output end drives the corresponding synchronous gear to rotate. Multiple synchronous gears are driven by a toothed transmission belt, so that the synchronous gear connected to the bottom of the rotating rod rotates synchronously, thereby driving the rotating rod to rotate. The rotating rod drives the threaded rod fixedly connected to it to rotate. Since the threaded rod is threadedly connected to the center block, when the threaded rod rotates, the support frame moves up and down in the lifting groove on the inner wall of the umbrella frame. The movement of the support frame drives the V-shaped material cylinder to move up and down, thereby adjusting the center of gravity position of the V-shaped material cylinder. The change in the center of gravity position makes the movement trajectory of the material more complex and variable, avoiding the stratification phenomenon of the material due to density differences, eliminating mixing dead zones, and further improving the mixing effect. Attached Figure Description

[0036] Figure 1 This is a schematic diagram of the overall structure of the present invention;

[0037] Figure 2 This is a front view of the overall structure of the present invention;

[0038] Figure 3 This is a schematic diagram of the structure of the drive component of the present invention;

[0039] Figure 4 This is a schematic diagram of the structure of the hybrid component of the present invention;

[0040] Figure 5 This is a schematic diagram of the structure of the synchronization component of the present invention;

[0041] Figure 6 This is a schematic diagram of the threaded rod structure of the present invention;

[0042] Figure 7 This is a schematic diagram of the trapezoidal block structure of the present invention;

[0043] Figure 8 This is a schematic diagram of the structure of the closed component of the present invention;

[0044] Figure 9 For the present invention Figure 8 Enlarged structural diagram of point A in the middle;

[0045] Figure 10 This is a schematic diagram of the structure of the flipping component of the present invention;

[0046] Figure 11 This is a schematic diagram of the first and second flip plates in their open and closed states according to the present invention.

[0047] In the picture:

[0048] 1. Base frame; 2. Drive assembly; 21. Servo motor; 22. Bearing frame; 23. Drive shaft; 3. Mixing assembly; 31. Feed top cover; 32. V-shaped material cylinder; 33. Support frame; 34. Discharge valve; 4. Lifting mechanism; 41. Umbrella frame; 42. Lifting groove; 43. Center block; 44. Threaded rod; 45. Rotating rod; 46. Connecting rod; 47. Synchronization assembly; 471. Diamond frame; 472. Rotating cylinder; 4 73. Toothed drive belt; 474. Synchronous gear; 5. Guide mechanism; 51. Trapezoidal block; 52. Steel wire rope; 53. Enclosure assembly; 531. Enclosure plate; 532. Center rod; 533. Driven wheel; 534. Rope fixing nail; 54. Reset frame; 55. Weight; 56. Telescopic spring; 57. Tilting assembly; 571. V-shaped guide plate; 572. Steering hinge; 573. First tilting plate; 574. Second tilting plate. Detailed Implementation

[0049] To make the above-mentioned objects, features and advantages of the present invention more apparent and understandable, the specific embodiments of the present invention will be described in detail below with reference to the accompanying drawings.

[0050] Example 1, referring to Figure 1 - Figure 11 The first embodiment of the present invention provides a mixing device for processing amlodipine benazepril capsules, including a base frame 1, a drive assembly 2 and a mixing assembly 3 disposed above the base frame 1, a flow guiding mechanism 5 disposed inside the mixing assembly 3, and a lifting mechanism 4 disposed between the flow guiding mechanism 5 and the drive assembly 2.

[0051] Reference Figure 2 - Figure 10 The mixing component 3 includes a support frame 33 installed inside the drive component 2. A V-shaped material cylinder 32 is fixedly connected to the inner wall of the support frame 33. The flow guiding mechanism 5 includes a closing component 53 and a flipping component 57 disposed on the inner wall of the V-shaped material cylinder 32. The flipping component 57 includes a V-shaped flow guide plate 571 fixedly connected to the inner wall of the V-shaped material cylinder 32. Both ends of the V-shaped flow guide plate 571 are fixedly installed with a steering hinge 572. The outer walls of the two steering hinges 572 are respectively fixedly connected with a first flipping plate 573 and a second flipping plate 574. When the first flipping plate 573 and the second flipping plate 574 rotate with the V-shaped material cylinder 32, they can open and close under the action of gravity to guide the capsule powder.

[0052] Specifically, the V-shaped guide plate 571 is closely fitted to the inner wall of the V-shaped material cylinder 32, and its shape is adapted to the V-shaped material cylinder 32, which can effectively guide the flow of materials. When the V-shaped material cylinder 32 rotates, the first flip plate 573 and the second flip plate 574 will automatically open and close under the action of gravity. During the opening and closing process, the flow direction and path of the capsule powder can be changed, so that the material forms a more complex convection and stirring effect in the V-shaped material cylinder 32, thereby breaking the agglomeration state of the material and further improving the uniformity of mixing.

[0053] With the help of the flipping component 57, the unique shape of the V-shaped material cylinder 32 causes the material to tumble and collide continuously inside the cylinder during rotation, increasing the contact opportunities between materials. At the same time, the first flipping plate 573 and the second flipping plate 574 open and close under the action of gravity, together with the V-shaped guide plate 571, to guide the capsule powder, change the material movement path, enhance the shear force and convection between materials, break up material agglomeration, and improve the mixing uniformity.

[0054] Reference Figure 6 - Figure 10 The sealing assembly 53 includes a central rod 532 rotatably connected to the inner wall of the V-shaped material cylinder 32. A sealing plate 531 is fixedly connected to the outer wall of the central rod 532. One end of the central rod 532 penetrates the V-shaped material cylinder 32 and is fixedly connected to a driven wheel 533. A rope nail 534 is fixedly connected to the inner wall of the driven wheel 533. When the sealing plate 531 closes the V-shaped material cylinder 32, it can reduce the space of the V-shaped material cylinder 32.

[0055] Reference Figure 6 - Figure 10 The flow guiding mechanism 5 also includes a reset frame 54 fixedly connected to the outer wall of the V-shaped material cylinder 32. A weight 55 is slidably connected to the inner wall of the reset frame 54. A telescopic spring 56 is fixedly connected between the bottom of the weight 55 and the inner wall of the reset frame 54. A steel wire rope 52 is fixedly connected to the end of the weight 55 away from the telescopic spring 56. The middle section of the steel wire rope 52 is fixedly connected to a rope fixing nail 534. When the steel wire rope 52 is pulled, the driven wheel 533 is driven to rotate through the rope fixing nail 534.

[0056] Specifically, the rope fixing nail 534 is used to securely fix the wire rope 52, ensuring that the driven wheel 533 can be stably driven to rotate when the wire rope 52 is pulled or released.

[0057] When the V-shaped material cylinder 32 moves upward via the guide mechanism 5, the trapezoidal block 51 pulls the wire rope 52. Since the middle section of the wire rope 52 is fixedly connected to the rope fixing nail 534, when the wire rope 52 is pulled, the rope fixing nail 534 drives the passive wheel 533 to rotate, thereby causing the central rod 532 to rotate. The closing plate 531 fixed on the outer wall of the central rod 532 then flips over. When the V-shaped material cylinder 32 moves downward, the weight 55 will pull the wire rope 52 in the opposite direction under the rebound force of the telescopic spring 56, causing the passive wheel 533 to rotate, thereby driving the closing plate 531 to reset. Thus, the flipping of the closing plate 531 reduces the internal space of the V-shaped material cylinder 32 in stages, which enhances the interaction between materials. The materials are subjected to stronger compression and collision in a smaller space, further improving the mixing efficiency.

[0058] Reference Figure 2 - Figure 6 The drive assembly 2 includes a bearing frame 22 fixedly installed on the top of the base frame 1. The inner wall of the bearing frame 22 is rotatably connected to the drive shaft 23. The lifting mechanism 4 includes an umbrella-shaped frame 41 fixedly installed on the outer wall of the drive shaft 23. A trapezoidal block 51 is fixedly connected to the outer wall of the umbrella-shaped frame 41. The outer wall of the trapezoidal block 51 is fixedly connected to the end of the wire rope 52 away from the weight 55. The inner wall of the umbrella-shaped frame 41 is provided with a lifting groove 42. The inner wall of the lifting groove 42 is slidably connected to the outer wall of the support frame 33. A center block 43 is fixedly connected to the inner wall of the umbrella-shaped frame 41. A threaded rod 44 is threadedly connected to the inside of the center block 43. A rotating rod 45 is fixedly connected to the outer wall of the threaded rod 44. The outer wall of the rotating rod 45 is rotatably connected to the inner wall of the support frame 33.

[0059] Reference Figure 2 - Figure 6 The lifting mechanism 4 also includes a connecting rod 46 fixedly connected to the bottom of the support frame 33, and a synchronization component 47 disposed at the bottom of the connecting rod 46. The synchronization component 47 includes a rhomboid frame 471 fixedly connected to the bottom of the connecting rod 46. Multiple synchronization gears 474 are rotatably connected to the inner wall of the rhomboid frame 471. Toothed transmission belts 473 are connected between the multiple synchronization gears 474. The bottom of the rotating rod 45 is connected to the corresponding synchronization gear 474. A rotating cylinder 472 is fixedly connected to the outer wall of the rhomboid frame 471. The output end of the rotating cylinder 472 is connected to the corresponding synchronization gear 474.

[0060] The lifting mechanism 4 operates the rotating cylinder 472, whose output end drives the corresponding synchronous gear 474 to rotate. Multiple synchronous gears 474 are driven by the toothed transmission belt 473, causing the synchronous gear 474 connected to the bottom of the rotating rod 45 to rotate synchronously, thereby driving the rotating rod 45 to rotate. The rotating rod 45 drives the threaded rod 44 fixedly connected to it to rotate. Since the threaded rod 44 is threadedly connected to the center block 43, when the threaded rod 44 rotates, the support frame 33 moves up and down in the lifting groove 42 on the inner wall of the umbrella frame 41. The movement of the support frame 33 drives the V-shaped material cylinder 32 to move up and down, thereby adjusting the center of gravity position of the V-shaped material cylinder 32. The change in the center of gravity position makes the movement trajectory of the material more complex and varied, avoiding the stratification phenomenon of the material due to density differences, eliminating mixing dead angles, and further improving the mixing effect.

[0061] Reference Figure 2 The drive assembly 2 also includes a servo motor 21 fixedly installed on the inner wall of the base frame 1, and the output shaft of the servo motor 21 is connected to the drive shaft 23; two symmetrically arranged feed top covers 31 are fixedly installed on the top of the V-shaped material cylinder 32, and a discharge valve 34 is fixedly installed on the bottom of the V-shaped material cylinder 32.

[0062] The servo motor 21, the feed top cover 31, and the discharge valve 34 are designed to handle feeding, discharging, and power supply.

[0063] Example 2, refer to Figure 1 - Figure 11 The second embodiment of the present invention provides a processing method for a mixing device for processing amlodipine and benazepril capsules, comprising the following steps:

[0064] Step 1: Accurately weigh amlodipine, benazepril, and excipients according to the formula, and sieve to ensure uniform particle size;

[0065] Step 2: Slowly pour the pre-treated material into the V-shaped material cylinder 32;

[0066] Step 3: Run drive component 2 to rotate V-shaped cylinder 32 for mixing;

[0067] Step 4: The first flip plate 573 and the second flip plate 574 open and close under the action of gravity to guide the material;

[0068] Step 5: Operate the lifting mechanism 4 to move the V-shaped material cylinder 32 up and down, adjust the center of gravity of the V-shaped material cylinder 32, and make its movement trajectory more complex and varied;

[0069] Step 6: When the V-shaped barrel 32 moves up and down, it drives the sealing component 53 to flip, which reduces the internal space of the V-shaped barrel 32 in stages and enhances the interaction of materials.

[0070] Step 7: After mixing, discharge and package.

[0071] Working principle of the invention:

[0072] During operation, the operator accurately weighs amlodipine, benazepril and excipients according to the formula, and sieves these materials to ensure uniform particle size. Then, the pre-treated materials are slowly poured into the V-shaped material cylinder 32 through the two feed top covers 31 to prepare for the subsequent mixing operation.

[0073] The servo motor 21 is activated, and its output shaft drives the drive shaft 23 to rotate. Through the umbrella frame 41 and the support frame 33, the V-shaped material cylinder 32 is rotated, causing the material inside the cylinder to begin to mix initially. During the rotation of the V-shaped material cylinder 32, the unique shape of the V-shaped material cylinder 32 causes the material to tumble and collide continuously inside the cylinder, increasing the contact opportunities between the materials. At the same time, the first flip plate 573 and the second flip plate 574 open and close under the action of gravity, together with the V-shaped guide plate 571, to guide the capsule powder, change the material movement path, enhance the shear force and convection between the materials, break up the material agglomeration, and improve the mixing uniformity.

[0074] Next, the rotating cylinder 472 is operated, and its output end drives the corresponding synchronous gear 474 to rotate. Multiple synchronous gears 474 are driven by the toothed transmission belt 473, so that the synchronous gear 474 connected to the bottom of the rotating rod 45 rotates synchronously, thereby driving the rotating rod 45 to rotate. The rotating rod 45 drives the threaded rod 44 fixedly connected to it to rotate. Since the threaded rod 44 is threadedly connected to the center block 43, when the threaded rod 44 rotates, the support frame 33 moves up and down in the lifting groove 42 on the inner wall of the umbrella frame 41. The movement of the support frame 33 drives the V-shaped material cylinder 32 to move up and down, thereby adjusting the center of gravity position of the V-shaped material cylinder 32. The change in the center of gravity position makes the movement trajectory of the material more complex and varied, avoiding the stratification phenomenon of the material due to density differences, eliminating the mixing dead zone, and further improving the mixing effect.

[0075] When the V-shaped cylinder 32 moves upward, the trapezoidal block 51 on the outer wall of the umbrella frame 41 pulls the wire rope 52. Since the middle section of the wire rope 52 is fixedly connected to the rope fixing nail 534, when the wire rope 52 is pulled, it drives the driven wheel 533 to rotate through the rope fixing nail 534, thereby causing the central rod 532 to rotate. The closing plate 531 fixed on the outer wall of the central rod 532 flips accordingly. When the V-shaped cylinder 32 moves downward, the weight 55 will pull the wire rope 52 in the opposite direction under the rebound force of the telescopic spring 56, causing the driven wheel 533 to rotate, thereby driving the closing plate 531 to reset. Thus, the flipping of the closing plate 531 reduces the internal space of the V-shaped cylinder 32 in stages, which enhances the interaction between materials. The materials are subjected to stronger compression and collision in a smaller space, further improving the mixing efficiency.

[0076] After mixing is complete, open the discharge valve 34 at the bottom of the V-shaped barrel 32 to discharge the mixed material, and then package it to complete the entire processing flow.

[0077] It should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit it. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention, and all such modifications or substitutions should be covered within the scope of the claims of the present invention.

Claims

1. A mixing apparatus for processing amlodipine and benazepril capsules, comprising a base frame (1), a drive assembly (2) disposed above the base frame (1), and a mixing assembly (3), characterized in that: The mixing component (3) is provided with a flow guiding mechanism (5) inside, and a lifting mechanism (4) is provided between the flow guiding mechanism (5) and the driving component (2); The mixing component (3) includes a support frame (33) installed inside the drive component (2), and a V-shaped material cylinder (32) is fixedly connected to the inner wall of the support frame (33). The flow guiding mechanism (5) includes a closing component (53) and a flipping component (57) disposed on the inner wall of the V-shaped material cylinder (32). The flipping assembly (57) includes a V-shaped guide plate (571) fixedly connected to the inner wall of the V-shaped material cylinder (32). Both ends of the V-shaped guide plate (571) are fixedly installed with a turning hinge (572). The outer walls of the two turning hinges (572) are respectively fixedly connected with a first flipping plate (573) and a second flipping plate (574). The first flipping plate (573) and the second flipping plate (574) can open and close under the action of gravity when the V-shaped material cylinder (32) rotates, so as to guide the capsule powder.

2. The mixing apparatus for processing amlodipine and benazepril capsules according to claim 1, characterized in that: The enclosing assembly (53) includes a central rod (532) rotatably connected to the inner wall of the V-shaped cylinder (32). A sealing plate (531) is fixedly connected to the outer wall of the central rod (532). One end of the central rod (532) penetrates the V-shaped cylinder (32) and is fixedly connected to a driven wheel (533). A rope nail (534) is fixedly connected to the inner wall of the driven wheel (533). When the sealing plate (531) encloses the V-shaped cylinder (32), it can reduce the space of the V-shaped cylinder (32).

3. The mixing apparatus for processing amlodipine and benazepril capsules according to claim 2, characterized in that: The flow guiding mechanism (5) also includes a reset frame (54) fixedly connected to the outer wall of the V-shaped material cylinder (32). A weight (55) is slidably connected to the inner wall of the reset frame (54). A telescopic spring (56) is fixedly connected between the bottom of the weight (55) and the inner wall of the reset frame (54). A steel wire rope (52) is fixedly connected to the end of the weight (55) away from the telescopic spring (56). The middle section of the steel wire rope (52) is fixedly connected to a rope fixing nail (534). When the steel wire rope (52) is pulled, the passive wheel (533) is driven to rotate through the rope fixing nail (534).

4. The mixing apparatus for processing amlodipine and benazepril capsules according to claim 3, characterized in that: The drive assembly (2) includes a bearing frame (22) fixedly installed on the top of the base frame (1). The inner wall of the bearing frame (22) is rotatably connected to a drive shaft (23). The lifting mechanism (4) includes an umbrella-shaped frame (41) fixedly installed on the outer wall of the drive shaft (23). A trapezoidal block (51) is fixedly connected to the outer wall of the umbrella-shaped frame (41). The outer wall of the trapezoidal block (51) is fixedly connected to the end of the wire rope (52) away from the weight (55).

5. The mixing apparatus for processing amlodipine and benazepril capsules according to claim 4, characterized in that: The inner wall of the umbrella frame (41) is provided with a lifting groove (42), the inner wall of the lifting groove (42) is slidably connected to the outer wall of the support frame (33), the inner wall of the umbrella frame (41) is fixedly connected to a central block (43), the inner thread of the central block (43) is connected to a threaded rod (44), the outer wall of the threaded rod (44) is fixedly connected to a rotating rod (45), and the outer wall of the rotating rod (45) is rotatably connected to the inner wall of the support frame (33).

6. The mixing apparatus for processing amlodipine and benazepril capsules according to claim 5, characterized in that: The lifting mechanism (4) further includes a connecting rod (46) fixedly connected to the bottom of the support frame (33), and a synchronization component (47) disposed at the bottom of the connecting rod (46). The synchronization component (47) includes a rhomboid frame (471) fixedly connected to the bottom of the connecting rod (46). Multiple synchronization gears (474) are rotatably connected to the inner wall of the rhomboid frame (471). Toothed transmission belts (473) are connected between the multiple synchronization gears (474). The bottom of the rotating rod (45) is connected to the corresponding synchronization gear (474). A rotating cylinder (472) is fixedly connected to the outer wall of the rhomboid frame (471). The output end of the rotating cylinder (472) is connected to the corresponding synchronization gear (474).

7. The mixing apparatus for processing amlodipine and benazepril capsules according to claim 1, characterized in that: The drive assembly (2) also includes a servo motor (21) fixedly installed on the inner wall of the base frame (1), and the output shaft of the servo motor (21) is connected to the drive shaft (23).

8. The mixing apparatus for processing amlodipine and benazepril capsules according to claim 1, characterized in that: The top of the V-shaped material cylinder (32) is fixedly equipped with two symmetrically arranged feed top covers (31), and the bottom of the V-shaped material cylinder (32) is fixedly equipped with a discharge valve (34).

9. A processing method for a mixing apparatus for processing amlodipine and benazepril capsules, comprising the mixing apparatus for processing amlodipine and benazepril capsules as described in claim 1, characterized in that, Includes the following steps: Step 1: Accurately weigh amlodipine, benazepril, and excipients according to the formula, and sieve to ensure uniform particle size; Step 2: Slowly pour the pretreated material into the V-shaped material cylinder (32); Step 3: Run the drive component (2) to drive the V-shaped barrel (32) to rotate for mixing; Step 4: The first flip plate (573) and the second flip plate (574) open and close under the action of gravity to guide the material; Step 5: Operate the lifting mechanism (4) to move the V-shaped cylinder (32) up and down, adjust the center of gravity of the V-shaped cylinder (32) to make its movement trajectory more complex and varied; Step 6: When the V-shaped barrel (32) moves up and down, it drives the closed component (53) to flip, which reduces the internal space of the V-shaped barrel (32) in stages and enhances the interaction between materials; Step 7: After mixing, discharge and package.

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