Antibacterial hygienic wet wipe and method for preparing the same

Abstract

The present application relates to the technical field of wet wipes, and particularly relates to a bacteriostatic sanitary wet wipe and a preparation method thereof. The bacteriostatic sanitary wet wipe comprises a fiber base and a bacteriostatic liquid. The wet wipe in the present application is alcohol-free and quaternary ammonium salt-free, is safe to use, and is suitable for skin sensitive people and infant care. Glycerol, butanediol, panthenol, allantoin and sodium hyaluronate synergistically provide moisturizing and skin barrier repair. The wet wipe is prepared by using a conventional spraying process and low-temperature conditions, can be directly applied to an existing wet wipe production line, and does not need additional equipment. The product still maintains the antibacterial effect under high-temperature and high-humidity storage conditions, and is suitable for commercial circulation and long-term storage.

Description

Technical Field

[0001] This invention relates to the field of wet wipes technology, and in particular to an antibacterial sanitary wet wipe and its preparation method. Background Technology

[0002] With the improvement of people's living standards and the enhancement of health awareness, wet wipes have been widely used in personal care, household cleaning, medical and health care, and many other fields. Traditional wet wipes mainly achieve their antibacterial function by adding chemical preservatives such as alcohol, quaternary ammonium salts, or organic acids. However, these ingredients generally have the following problems:

[0003] First, alcohol-based wipes are highly irritating. While low-molecular-weight alcohols such as ethanol and isopropanol have excellent instantaneous bactericidal effects, they can also damage the skin's lipid barrier, causing adverse reactions such as dryness, stinging, and allergies. Their safety is particularly poor when used on infants, children, those with sensitive skin, or those with broken skin.

[0004] Secondly, quaternary ammonium salt antibacterial agents pose biosafety risks. Cationic surfactants such as benzalkonium chloride, chlorhexidine, and cetyltrimethylammonium bromide can form residual films on the skin, which may lead to cytotoxic reactions or microecological imbalance, and can easily cause persistent environmental pollution.

[0005] Secondly, chemical antibacterial agents have limited stability. Most small-molecule preservatives are prone to decomposition, oxidation, or volatilization under high temperature, high humidity, or strong light conditions, which leads to a decrease in the antibacterial effect of wet wipes during storage and a limited shelf life.

[0006] On the other hand, with the rise of green and sustainable consumption concepts, consumers have placed higher demands on wet wipes products:

[0007] The industry desires products that possess gentle, low-irritation natural antibacterial properties, while also exhibiting long-lasting, stable antibacterial activity and a pleasant skin feel. Therefore, significantly improving antibacterial performance and stability while ensuring safety has become a pressing technical challenge for the industry.

[0008] In recent years, polyphenolic compounds (such as tannic acid, ellagic acid, chlorogenic acid, and rhubarb polyphenols) from natural plant extracts have gradually attracted attention due to their natural origin, antioxidant properties, and antibacterial effects. Polyphenols can inhibit the growth of various pathogenic bacteria through mechanisms such as disrupting bacterial cell membranes, inhibiting enzyme activity, and chelating metal ions. However, polyphenolic compounds themselves have drawbacks such as easy oxidation, photosensitivity, poor solubility, and difficulty in maintaining activity in aqueous systems, which limits their application in daily chemical products such as wet wipes.

[0009] Meanwhile, metal-organic frameworks (MOFs), as porous crystalline structures formed by the self-assembly of metal ions and organic ligands, possess high specific surface area, structural designability, and good loading capacity. Studies have shown that certain MOF materials (such as ZIF-8, Cu-MOF, and Bi-MOF) can slowly release metal ions and produce synergistic antibacterial effects, demonstrating promising prospects in antibacterial dressings, air purification, and biomedical materials. However, traditional MOF materials have poor aqueous stability, easily collapsing or rapidly releasing metal ions in humid environments, making it difficult to maintain antibacterial properties over a long period.

[0010] Therefore, effectively combining natural polyphenols with MOF materials, utilizing both the bioactivity of polyphenols and the structural stability and sustained-release properties of MOFs, is currently a hot topic in technological research. Some studies have attempted to use strategies such as "polyphenol-metal complexation" or "polyphenol surface-modified MOFs" to improve material stability and biocompatibility, but their mature application in daily wet wipe formulations has not yet been seen, mainly due to limitations such as poor dispersibility, unstable pH of the system, and insufficient compatibility with moisturizing ingredients.

[0011] Furthermore, most existing wet wipes use a single moisturizing system (such as glycerin or propylene glycol) as their base liquid, lacking the function of repairing the skin barrier. Long-term use may still cause mild dryness or tightness, which is not conducive to the skin's microecological balance.

[0012] In summary, current technologies still lack antibacterial wipes that combine the safety of natural ingredients, the stability of MOF structure, and long-lasting antibacterial activity. There is an urgent need for a novel formulation system that can achieve highly effective, long-lasting, and gentle antibacterial care at room temperature without using high-concentration alcohol or strong irritating preservatives, while also possessing excellent skin affinity and storage stability. Summary of the Invention

[0013] The purpose of this invention is to provide a mild and safe antibacterial wipe with long-lasting antibacterial properties, in order to overcome the problems of skin irritation, unstable antibacterial performance, and short shelf life caused by the use of chemical preservatives in existing wipes.

[0014] This invention combines polyphenolic natural active ingredients (such as ellagic acid, tannic acid, and rhubarb polyphenols) with metal ions to form a metal-organic framework (MOF) material, and scientifically combines moisturizing, repairing, and preservative systems to enable the resulting wipes to maintain a highly effective and long-lasting antibacterial effect under normal temperature storage conditions, while also having good skin compatibility.

[0015] This invention is achieved through the following technical solution:

[0016] An antibacterial sanitary wipe, comprising a fiber base and an antibacterial liquid; the fiber base is a spunlace nonwoven fabric; the antibacterial liquid comprises the following components: a metal-organic framework antibacterial material, deionized water, glyceryl butanediol, ethylhexylglycerin, panthenol, PEG-40 hydrogenated castor oil, citric acid, sodium citrate, allantoin, sodium hyaluronate, and 0.6% phenoxyethanol; the metal-organic framework antibacterial material is selected from at least one of hydrothermal bismuth ellagicate MOF, bismuth ellagicate MOF, tannic acid-modified ZIF-8, rhubarb polyphenol-modified ZIF-8, and water-extracted rhubarb polyphenol-modified ZIF-8.

[0017] Further, the antibacterial solution comprises, by weight: 2 parts of metal-organic framework antibacterial material, 85.5 parts of deionized water, 2 parts of glycerol, 3 parts of butylene glycol, 0.5 parts of ethylhexylglycerin, 0.3 parts of panthenol, 0.3 parts of PEG-40 hydrogenated castor oil, 0.15 parts of citric acid, 0.25 parts of sodium citrate, 0.3 parts of allantoin, 0.1 parts of sodium hyaluronate, and 0.6 parts of phenoxyethanol.

[0018] Furthermore, the pH of the antibacterial solution is 5.5–6.0.

[0019] Furthermore, the metal-organic framework antibacterial material is selected from hydrothermal bismuth ellagicate MOF.

[0020] Furthermore, the preparation method of the hydrothermal bismuth ellagicate MOF is as follows: 10 mg of ellagic acid and 24 mg of bismuth acetate are added to 3 mL of deionized water, then transferred to a high-pressure reactor, heated to 120°C and maintained for 16 hours, then centrifuged at 8000 rpm for 10 minutes, and then placed in a 60°C oven overnight; after washing with water and ethanol, it is dried.

[0021] Furthermore, the metal-organic framework antibacterial material is selected from bismuth ellagicate (MOF).

[0022] Furthermore, the preparation method of the bismuth ellagicate MOF is as follows:

[0023] Add 3.3 g ellagic acid and 7.6 g bismuth acetate to a beaker containing a mixture of 600 mL water and acetic acid; stir the solution for 48 hours, then centrifuge and dry.

[0024] Furthermore, the wet wipes exhibit an initial inhibition rate of ≥99% against Staphylococcus aureus, and after being stored at 30°C and 75% relative humidity for 180 days, the inhibition rate against Staphylococcus aureus remains ≥92%.

[0025] This invention also provides a method for preparing antibacterial sanitary wipes, comprising the following steps: spraying an antibacterial liquid at a temperature of 40°C onto a spunlace nonwoven fabric, repeating the spraying once. The spraying amount is 150 g / m².2 .

[0026] Compared with the prior art, the present invention has the following advantages and beneficial effects:

[0027] The MOF material is formed by compounding with natural polyphenolic compounds. Utilizing the porous structure and antibacterial properties of metal ions, it achieves sustained release and stable protection of active ingredients. The hydroxyl groups in the natural polyphenols coordinate with the metal skeleton of the MOF, improving system stability and antioxidant properties. A citric acid / sodium citrate buffer system maintains the pH at 5.5–6.0 to keep the polyphenols and bioactive components stable. Glycerin, butylene glycol, and sodium hyaluronate form a triple moisturizing system to enhance skin feel and hydration. PEG-40 hydrogenated castor oil is used to solubilize the MOF dispersion and prevent sedimentation or clumping. Phenoxyethanol and ethylhexylglycerin are combined to provide broad-spectrum antibacterial properties; their synergistic effect with the MOF antibacterial agent avoids the irritation of traditional alcohols or quaternary ammonium salts. The antibacterial solution is heated to 40°C and then uniformly applied to a spunlace nonwoven fabric by spraying at a rate of 150 g / m². After static adsorption, the product is sealed and packaged. The resulting wipes exhibit an initial inhibition rate of ≥99% against Staphylococcus aureus, and maintain an inhibition rate of ≥97% after 180 days of storage, demonstrating significant long-term antibacterial stability. The wipes of this invention are alcohol-free and quaternary ammonium salt-free, making them safe to use and suitable for sensitive skin individuals and infant care. Glycerin, butylene glycol, panthenol, allantoin, and sodium hyaluronate work synergistically to provide moisturizing and skin barrier repair effects. Prepared using conventional spraying technology and low-temperature conditions, they can be directly applied to existing wipes production lines without additional equipment. The product maintains its antibacterial effect even under high-temperature and high-humidity storage conditions, making it suitable for commercial distribution and long-term storage. Detailed Implementation

[0028] To make the objectives, technical solutions, and advantages of this invention clearer, the invention will be further described in detail below with reference to the embodiments. The illustrative embodiments and descriptions of this invention are only used to explain this invention and are not intended to limit this invention.

[0029] Example 1

[0030] An antibacterial sanitary wipe, the antibacterial sanitary wipe comprising a fiber base and an antibacterial liquid.

[0031] The fiber base is spunlace nonwoven fabric;

[0032] The antibacterial solution comprises: 2 parts hydrothermal bismuth ellagicate MOF, 85.5 parts deionized water, 2 parts glycerol, 3 parts butylene glycol, 0.5 parts ethylhexylglycerol, 0.3 parts panthenol, 0.3 parts PEG-40 hydrogenated castor oil, 0.15 parts citric acid, 0.25 parts sodium citrate, 0.3 parts allantoin, 0.1 parts sodium hyaluronate, and 0.6 parts phenoxyethanol. The pH of the antibacterial solution is controlled between 5.5 and 6.0.

[0033] The method for preparing the antibacterial sanitary wipes is as follows:

[0034] An antibacterial solution at 40℃ was sprayed onto the spunlace nonwoven fabric once, with a spraying amount of 150g / m². 2 .

[0035] In this embodiment, the hydrothermal method for preparing bismuth ellagicate MOF is as follows: 10 mg of ellagic acid and 24 mg of bismuth acetate are added to 3 mL of deionized water, then transferred to a high-pressure reactor, heated to 120°C and maintained for 16 hours, then centrifuged at 8000 rpm for 10 minutes, and then placed in a 60°C oven overnight; after washing with water and ethanol, it is dried overnight at 60°C.

[0036] Example 2

[0037] An antibacterial sanitary wipe, the antibacterial sanitary wipe comprising a fiber base and an antibacterial liquid.

[0038] The fiber base is spunlace nonwoven fabric;

[0039] The antibacterial solution comprises: 2 parts bismuth ellagicate MOF, 85.5 parts deionized water, 2 parts glycerol, 3 parts butylene glycol, 0.5 parts ethylhexylglycerin, 0.3 parts panthenol, 0.3 parts PEG-40 hydrogenated castor oil, 0.15 parts citric acid, 0.25 parts sodium citrate, 0.3 parts allantoin, 0.1 parts sodium hyaluronate, and 0.6 parts phenoxyethanol. The pH value of the antibacterial solution is controlled between 5.5 and 6.0.

[0040] The method for preparing the antibacterial sanitary wipes is as follows:

[0041] An antibacterial solution at 40℃ was sprayed onto the spunlace nonwoven fabric once, with a spraying amount of 150g / m². 2 .

[0042] The preparation method of bismuth ellagicate MOF in this embodiment is as follows:

[0043] Add 3.3 g ellagic acid and 7.6 g bismuth acetate to a beaker containing a mixture of 600 mL water and acetic acid (6 vol.% acetic acid); stir the solution for 48 hours, then centrifuge at 8000 rpm for 10 minutes, and then place it in a 60 °C oven overnight; wash with water and ethanol, and then dry overnight at 60 °C.

[0044] Example 3

[0045] An antibacterial sanitary wipe, the antibacterial sanitary wipe comprising a fiber base and an antibacterial liquid.

[0046] The fiber base is spunlace nonwoven fabric;

[0047] The antibacterial solution comprises: 2 parts tannic acid-modified ZIF-8, 85.5 parts deionized water, 2 parts glycerol, 3 parts butylene glycol, 0.5 parts ethylhexylglycerin, 0.3 parts panthenol, 0.3 parts PEG-40 hydrogenated castor oil, 0.15 parts citric acid, 0.25 parts sodium citrate, 0.3 parts allantoin, 0.1 parts sodium hyaluronate, and 0.6 parts phenoxyethanol. The pH of the antibacterial solution is controlled between 5.5 and 6.0.

[0048] The method for preparing the antibacterial sanitary wipes is as follows:

[0049] An antibacterial solution at 40℃ was sprayed onto the spunlace nonwoven fabric once, with a spraying amount of 150g / m². 2 .

[0050] In this embodiment, the preparation method of tannic acid modified ZIF-8 is as follows: 2-Methylimidazole (6.5 g) was mixed with ethanol (200.0 mL) and allowed to stand at room temperature for 30 min. Then, 20.0 mL of ethanol solution containing tannic acid (0.5 g) was added and allowed to stand at room temperature for another 30 min. After the system stood at room temperature for 24 h, the solid was collected by centrifugation at 6000 rpm for 15 min. The solid was washed three times with ethanol and dried under vacuum at 60°C overnight to obtain tannic acid modified ZIF-8.

[0051] Example 4

[0052] An antibacterial sanitary wipe, the antibacterial sanitary wipe comprising a fiber base and an antibacterial liquid.

[0053] The fiber base is spunlace nonwoven fabric;

[0054] The antibacterial solution comprises: 2 parts rhubarb polyphenol-modified ZIF-8, 85.5 parts deionized water, 2 parts glycerol, 3 parts butylene glycol, 0.5 parts ethylhexylglycerin, 0.3 parts panthenol, 0.3 parts PEG-40 hydrogenated castor oil, 0.15 parts citric acid, 0.25 parts sodium citrate, 0.3 parts allantoin, 0.1 parts sodium hyaluronate, and 0.6 parts phenoxyethanol. The pH of the antibacterial solution is controlled between 5.5 and 6.0.

[0055] The method for preparing the antibacterial sanitary wipes is as follows:

[0056] An antibacterial solution at 40℃ was sprayed onto the spunlace nonwoven fabric once, with a spraying amount of 150g / m². 2 .

[0057] In this embodiment, the preparation method of ZIF-8 modified with rhubarb polyphenols is as follows: 2-Methylimidazole (6.5 g) was mixed with ethanol (200.0 mL) and allowed to stand at room temperature for 30 min. Then, ethanol solution (20.0 mL) containing rhubarb polyphenol (0.5 g) was added and allowed to stand at room temperature for another 30 min. After the system stood at room temperature for 24 h, the solid was collected by centrifugation at 6000 rpm for 15 min. The solid was washed three times with ethanol and dried under vacuum at 60°C overnight to obtain rhubarb polyphenol modified ZIF-8.

[0058] The extraction method of rhubarb polyphenols is as follows: Take 0.2g of dried powder of rhubarb root and rhizome, mix it with 18mL of 75% (v / v) ethanol water in a flask, and extract it by ultrasonic extraction for 30 minutes at a power of 800W and a working frequency of 45kHz.

[0059] After extraction, the solution was filtered through a 0.45 μm filter membrane, and 5 mL of the filtrate was evaporated on a petri dish and then dried in a water bath. The dried residue was dissolved in 10 mL of water, 1 mL of hydrochloric acid was added, and the mixture was heated under reflux for 30 minutes. Then, it was extracted twice with 20 mL of diethyl ether. Finally, the diethyl ether solutions obtained from the two extractions were combined and dried under vacuum to obtain rhubarb polyphenols.

[0060] Example 5

[0061] An antibacterial sanitary wipe, the antibacterial sanitary wipe comprising a fiber base and an antibacterial liquid.

[0062] The fiber base is spunlace nonwoven fabric;

[0063] The antibacterial solution comprises: 2 parts water-extracted rhubarb polyphenol-modified ZIF-8, 85.5 parts deionized water, 2 parts glycerol, 3 parts butylene glycol, 0.5 parts ethylhexylglycerol, 0.3 parts panthenol, 0.3 parts PEG-40 hydrogenated castor oil, 0.15 parts citric acid, 0.25 parts sodium citrate, 0.3 parts allantoin, 0.1 parts sodium hyaluronate, and 0.6 parts phenoxyethanol. The pH of the antibacterial solution is controlled between 5.5 and 6.0.

[0064] The method for preparing the antibacterial sanitary wipes is as follows:

[0065] An antibacterial solution at 40℃ was sprayed onto the spunlace nonwoven fabric once, with a spraying amount of 150g / m². 2 .

[0066] The preparation method of ZIF-8 modified with water-extracted rhubarb polyphenols in this embodiment is as follows:

[0067] Will 2-Methylimidazole (6.5 g) was mixed with ethanol (200.0 mL) and allowed to stand at room temperature for 30 min. Then, ethanol solution (20.0 mL) containing 0.5 g of water-extracted rhubarb polyphenols was added, and the mixture was allowed to stand at room temperature for another 30 min. After the system stood at room temperature for 24 h, the solid was collected by centrifugation at 6000 rpm for 15 min. The solid was washed three times with ethanol and dried under vacuum at 60°C overnight to obtain rhubarb polyphenol-modified ZIF-8.

[0068] The extraction method of water-extracted rhubarb polyphenols is as follows: Weigh 10g of dried powder of rhubarb root and rhizome, decoct it three times with 100mL of water at 100℃ for 1 hour each time; after filtering the decoction, dry it under reduced pressure at 60℃ to obtain water-extracted rhubarb polyphenols.

[0069] Test Example 1

[0070] Performance tests were conducted on the antibacterial sanitary wipes of Examples 1-5 of this application. The antibacterial properties were determined according to the national standard GB / T15979-2002. The packaged wipe material was stored at 30°C and 75% relative humidity for 180 days, and the stability was evaluated by measuring the antibacterial properties. The results are shown in Table 1.

[0071] Table 1 Performance Tests

[0072]

[0073] The specific embodiments described above further illustrate the purpose, technical solution, and beneficial effects of the present invention. It should be understood that the above description is only a specific embodiment of the present invention and is not intended to limit the scope of protection of the present invention. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the scope of protection of the present invention.

Claims

1. A bacteriostatic sanitary wet wipe, characterized in that, The bacteriostatic sanitary wet tissue comprises a fibrous base and a bacteriostatic liquid; the fibrous base is a spunlace non-woven fabric; the bacteriostatic liquid comprises the following components: a metal organic framework bacteriostatic material, deionized water, glycerol, butanediol, ethylhexyl glycerin, panthenol, hydrogenated castor oil, citric acid, sodium citrate, allantoin, sodium hyaluronate and phenoxyethanol; the metal organic framework bacteriostatic material is selected from at least one of the following: a hydrothermal method tannic acid bismuth MOF, a tannic acid bismuth MOF, a tannic acid modified rhubarb polyphenol modified and water extracted rhubarb polyphenol modified ​ The preparation method of the hydrothermal tannic acid bismuth MOF is: 10 mg of tannic acid and 24 mg of bismuth acetate are added to 3 mL of deionized water, and then transferred to a reaction kettle, and then heated to 120 DEG C for 16 hours, then centrifuged at 8000 rpm for 10 minutes, and then placed in a 60 DEG C oven overnight; after washing with water and ethanol, drying; The preparation method of the tannic acid bismuth MOF is: 3.3 g of tannic acid and 7.6 g of bismuth acetate are added to a mixture containing 600 mL of water and acetic acid; the solution is stirred for 48 hours, then centrifuged and dried to obtain.

2. The bacteriostatic sanitary wet wipe of claim 1 wherein, The bacteriostatic liquid comprises, by weight parts: 2 parts of metal organic framework bacteriostatic material, 85.5 parts of deionized water, 2 parts of glycerol, 3 parts of butanediol, 0.5 parts of ethylhexylglycerin, 0.3 parts of panthenol, 0.3 parts of hydrogenated castor oil, 0.15 parts of citric acid, 0.25 parts of sodium citrate, 0.3 parts of allantoin, 0.1 parts of sodium hyaluronate, 0.6 parts of phenoxyethanol.

3. The bacteriostatic sanitary wet wipe of claim 2 wherein, The pH of the bacteriostatic solution is 5.5-6.

0.

4. The bacteriostatic sanitary wet wipe of claim 1 wherein, The metal organic framework bacteriostatic material is selected from a hydrothermal tannic acid bismuth MOF.

5. The bacteriostatic sanitary wet wipe of claim 1 wherein, The metal organic framework bacteriostatic material is selected from a tannic acid bismuth MOF.

6. The bacteriostatic sanitary wet wipe of any one of claims 1 to 5, wherein, The initial bacteriostatic rate of the wet wipe on Staphylococcus aureus is ≥99%, and after being stored at 30 DEG C and a relative humidity of 75% for 180 days, the bacteriostatic rate on Staphylococcus aureus is maintained at ≥92%.

7. A method of making bacteriostatic sanitary wipes according to any of claims 1 to 5, characterized in that, The steps include: The bacteriostatic solution at a temperature of 40 DEG C is sprayed onto the spunlace non-woven fabric, and the spraying is performed 1 time. The temperature of the bacteriostatic solution is 40 DEG C.

8. The production method as claimed in claim 7, characterized in that, The spraying amount is 150 g / m 2 .

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