Preparation of diosgenin composition with whitening, soothing and repairing effects

Abstract

The invention provides an inulin composition for stabilizing and thickening a cosmetic system, the inulin composition comprises short-chain inulin, medium-chain inulin and long-chain inulin, and the mass ratio of the short-chain inulin to the medium-chain inulin to the long-chain inulin is (0.6-1.8): (0.6-1.2): (1.6-3.6); the invention further provides a composition for inhibiting tyrosinase activity, the composition comprises the grape seed extract (grape polyphenol) and honokiol, and the mass ratio of the grape seed extract (grape polyphenol) to honokiol is (0.4-0.6): (0.05-0.10). The invention further provides a cosmetic composition, and the cosmetic composition has a certain synergistic effect on the stability and whitening effect of a cosmetic system under a certain mass ratio.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of cosmetics, and particularly relates to a cosmetic composition with whitening and soothing and repairing effects and application thereof. BACKGROUND

[0002] Skin problems have become a hot topic in today's society, and more and more functional skin care products have been developed, such as products with anti-aging, soothing, whitening and brightening, moisturizing and other effects, which have gradually been favored by consumers.

[0003] Inulin, also known as inulin, is a natural fructan mixture. Inulin is a reserve polysaccharide in plants. In nature, inulin is widely distributed, and the content is highest in plants. According to the length of the molecular chain, inulin can be divided into long-chain inulin, medium-chain inulin and short-chain inulin. In general, inulin with an average degree of polymerization of less than or equal to 10 is referred to as short-chain inulin, and inulin with an average degree of polymerization of greater than or equal to 23 is referred to as long-chain inulin. Inulin extracted from natural plants, Jerusalem artichoke or chicory contains short-chain inulin, medium-chain inulin and long-chain inulin. In the field of cosmetics, inulin mainly plays a role as a thickening agent, a stabilizing agent, etc.

[0004] Grape seed extract is a mixture of polyphenols, which is mainly derived from grape seeds. The active ingredients include grape polyphenols, procyanidins, resveratrol, anthocyanins, catechins, epicatechin, etc. Studies have shown that grape polyphenols have antioxidant, anti-inflammatory and soothing effects. In addition, procyanidins can effectively inhibit the activity of tyrosinase and inhibit the production of melanin. Grape polyphenols can also have a synergistic effect with vitamins to achieve whitening.

[0005] Honokiol is mainly derived from Chinese medicine Magnolia officinalis. It has antioxidant, anti-inflammatory, anti-drug-resistant bacteria, and anti-allergic effects. Studies have shown that honokiol can effectively inhibit the proliferation of B16 melanoma cells and the production of intracellular melanin, and the inhibitory effect is related to the time and concentration. Studies have also shown that 0.01% honokiol has an inhibition rate of 64.2% on tyrosinase, so honokiol has a certain whitening effect.

[0006] In recent years, due to the problems such as skin irritation caused by organic ingredients in cosmetics, plant extracts with natural sources and certain effects have become a research hotspot in the field of cosmetics. SUMMARY

[0007] The present application provides a cosmetic composition with stable system, whitening and soothing and repairing effects, safe and natural ingredients, and application thereof.

[0008] The present application relates to the following invention content: 1. A composition comprising a mixture of short chain inulin, medium chain inulin and long chain inulin, wherein the mass ratio of the short chain inulin, medium chain inulin and long chain inulin is (0.6-1.8):(0.6-1.2):(1.6-3.6) for use in stabilizing and thickening a cosmetic system.

[0009] 2. The composition according to item 1, wherein the mass ratio of the short chain inulin, medium chain inulin and long chain inulin is (0.6-1.8):(0.6-1.2):(1.8-3.0).

[0010] 3. A composition comprising a mixture of short chain inulin, medium chain inulin and long chain inulin, wherein the mass ratio of the short chain inulin, medium chain inulin and long chain inulin is (0.6-1.8):(0.6-1.2):(1.6-3.6) for use in stabilizing and thickening a cosmetic system.

[0011] 4. The use according to item 3, wherein the mass ratio of the short chain inulin, medium chain inulin and long chain inulin is (0.6-1.8):(0.6-1.2):(1.8-3.0).

[0012] 5. A composition for inhibiting the activity of tyrosinase, wherein the composition comprises grape seed extract and honokiol, and the mass ratio of the grape seed extract and honokiol is (0.4-0.6):(0.05-0.10).

[0013] 6. The composition according to item 5, wherein the grape seed extract is selected from one or more of the group consisting of grape polyphenol, proanthocyanidin, resveratrol, anthocyanin, catechin, epicatechin. Preferably, the grape seed extract is grape polyphenol.

[0014] 7. Use of a composition comprising grape seed extract and honokiol for inhibiting the activity of tyrosinase, wherein the mass ratio of the grape seed extract and honokiol is (0.4-0.6):(0.05-0.10).

[0015] 8. The use according to item 7, wherein the grape seed extract is selected from one or more of the group consisting of grape polyphenol, proanthocyanidin, resveratrol, anthocyanin, catechin, epicatechin. Preferably, the grape seed extract is grape polyphenol.

[0016] 9. A cosmetic composition comprising a yam extract, a mixture of inulins, and sodium hyaluronate.

[0017] 10. The cosmetic composition according to item 9, wherein the inulin mixture consists of short chain inulin, medium chain inulin and long chain inulin, and the mass ratio of the short chain inulin, medium chain inulin and long chain inulin is (0.6-1.8):(0.6-1.2):(1.6-3.6).

[0018] 11. The cosmetic composition according to item 10, wherein the mass ratio of the short chain inulin, medium chain inulin and long chain inulin is (0.6-1.8):(0.6-1.2):(1.8-3.0).

[0019] 12. The cosmetic composition according to item 9, wherein the composition further comprises grape seed extract and honokiol.

[0020] 13. The cosmetic composition according to item 12, wherein the grape seed extract is selected from one or more of grape polyphenol, proanthocyanidin, resveratrol, anthocyanin, catechin and epicatechin. Preferably, the grape seed extract is grape polyphenol.

[0021] 14. The cosmetic composition according to item 12, wherein the mass ratio of the grape seed extract and honokiol is (0.4-0.6):(0.05-0.10).

[0022] 15. The cosmetic composition according to any one of items 9-14, wherein the composition further comprises one or more of diosgenin, artemisia extract and licorice (root) extract.

[0023] 16. A cosmetic preparation, wherein the cosmetic preparation comprises the cosmetic composition according to any one of items 9-15 and conventional adjuvants in the cosmetic field.

[0024] 17. Use of the cosmetic composition according to any one of items 9-15 or the cosmetic preparation according to item 16 in skin whitening.

[0025] Inventive effects: 1. The inulin composition according to the present application comprises short chain inulin, medium chain inulin and long chain inulin, and the short chain inulin, medium chain inulin and long chain inulin have a certain synergistic effect on the viscosity of the cosmetic system at a certain mass ratio, and can stabilize and thicken the system; 2. The composition for inhibiting the activity of tyrosinase according to the present application comprises grape seed extract and honokiol, and the grape seed extract and honokiol have a certain synergistic effect on the inhibition of the activity of tyrosinase at a certain mass ratio, can significantly inhibit the activity of tyrosinase, and have excellent effect on skin whitening; 3. The cosmetic composition of the present application, the main components of which include yam extract, short-chain inulin, medium-chain inulin, long-chain inulin and sodium hyaluronate, the short-chain inulin, medium-chain inulin and long-chain inulin in the composition can produce synergistic effect on the viscosity of the composition at a certain mass ratio, thereby achieving the effect of stabilizing the system and thickening; in addition to the above effective components, the composition also contains diosgenin, extract of capillaris, licorice (root) extract, grape seed extract and honokiol, the grape seed extract and honokiol in the composition can produce synergistic effect on the inhibition of tyrosine kinase activity at a certain mass ratio, thereby having significant whitening and soothing and repairing effects. DETAILED DESCRIPTION

[0026] The present application will be further described in conjunction with the examples. It should be understood that the examples are only used to further illustrate and explain the present application, and are not intended to limit the present application.

[0027] Unless otherwise defined, the technical and scientific terms used in the present specification have the same meaning as commonly understood by one of ordinary skill in the art. "Include" or "includes" as used throughout the specification and claims, is an open term that is intended to mean "includes but is not limited to". The description that follows is intended to be a general description of the preferred embodiments of the present application, and is not intended in any way to limit the scope of the present application. The scope of the present application is defined by the appended claims. Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this disclosure belongs.

[0028] The present application provides an inulin composition for stabilizing and thickening a cosmetic system, wherein the inulin composition comprises short-chain inulin, medium-chain inulin and long-chain inulin, and the mass ratio of the short-chain inulin, medium-chain inulin and long-chain inulin is (0.6-1.8):(0.6-1.2):(1.6-3.6). For the mass ratio of (0.6-1.8):(0.6-1.2):(1.6-3.6), 0.6-1.8 can be 0.6, 0.7, 0.8, 0.9, 1.0, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, and any range between these values; 0.6-1.2 can be 0.6, 0.7, 0.8, 0.9, 1.0, 1.1, 1.2, and any range between these values; 1.6-3.6 can be 1.6, 1.7, 1.8, 1.9, 2.0, 2.1, 2.2, 2.3, 2.4, 2.5, 2.6, 2.7, 2.8, 2.9, 3, 3.1, 3.2, 3.3, 3.4, 3.5, 3.6, and any range between these values.

[0029] In some preferred embodiments, the mass ratio of short-chain inulin, medium-chain inulin, and long-chain inulin is (0.6-1.8):(0.6-1.2):(1.8-3.0).

[0030] In some more preferred embodiments, the mass ratio of short-chain inulin, medium-chain inulin, and long-chain inulin is 1.2:0.6:3.0, 1.5:0.6:2.7, 0.6:1.2:3.0, 1.2:1.2:2.4, or 1.8:1.2:1.8.

[0031] The present application also provides a use of an inulin composition in stabilizing, thickening a cosmetic system, wherein the inulin composition comprises short-chain inulin, medium-chain inulin, and long-chain inulin, and the mass ratio of the short-chain inulin, medium-chain inulin, and long-chain inulin is (0.6-1.8):(0.6-1.2):(1.6-3.6). For the mass ratio of (0.6-1.8):(0.6-1.2):(1.6-3.6), 0.6-1.8 can be 0.6, 0.7, 0.8, 0.9, 1.0, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, and any range between these values; 0.6-1.2 can be 0.6, 0.7, 0.8, 0.9, 1.0, 1.1, 1.2, and any range between these values; 1.6-3.6 can be 1.6, 1.7, 1.8, 1.9, 2.0, 2.1, 2.2, 2.3, 2.4, 2.5, 2.6, 2.7, 2.8, 2.9, 3, 3.1, 3.2, 3.3, 3.4, 3.5, 3.6, and any range between these values.

[0032] In some preferred embodiments, the mass ratio of short-chain inulin, medium-chain inulin, and long-chain inulin is (0.6-1.8):(0.6-1.2):(1.8-3.0).

[0033] In some more preferred embodiments, the mass ratio of short-chain inulin, medium-chain inulin, and long-chain inulin is 1.2:0.6:3.0, 1.5:0.6:2.7, 0.6:1.2:3.0, 1.2:1.2:2.4, or 1.8:1.2:1.8.

[0034] The present application also provides a composition for inhibiting the activity of tyrosinase, wherein the composition comprises grape seed extract and honokiol, and the mass ratio of the grape seed extract and honokiol is (0.4-0.6):(0.05-0.10). For the mass ratio of (0.4-0.6):(0.05-0.10), 0.4-0.6 can be 0.4, 0.5, 0.6, and any range between these values; 0.05-0.10 can be 0.05, 0.06, 0.07, 0.08, 0.09, 0.10, and any range between these values.

[0035] In the present application, the grape seed extract is selected from one or more of grape polyphenol, proanthocyanidin, resveratrol, anthocyanin, catechin, and epicatechin; preferably grape polyphenol.

[0036] In some preferred embodiments, the mass ratio of grape seed extract and honokiol is 0.4:0.05, 0.5:0.05, 0.6:0.05, 0.4:0.08, 0.5:0.08, 0.5:0.10, 0.6:0.08, 0.6:0.10, or 0.4:0.10.

[0037] The present application also provides the use of a composition comprising grape seed extract and honokiol for inhibiting the activity of tyrosinase, wherein the mass ratio of the grape seed extract and honokiol is (0.4-0.6):(0.05-0.10). For the mass ratio of (0.4-0.6):(0.05-0.10), 0.4-0.6 can be 0.4, 0.5, 0.6, and any range between these values; 0.05-0.10 can be 0.05, 0.06, 0.07, 0.08, 0.09, 0.10, and any range between these values.

[0038] In some preferred embodiments, the mass ratio of grape seed extract and honokiol is 0.4:0.05, 0.5:0.05, 0.6:0.05, 0.4:0.08, 0.5:0.08, 0.5:0.10, 0.6:0.08, 0.6:0.10, or 0.4:0.10.

[0039] The present application also provides a cosmetic composition comprising yam extract, inulin mixture, and sodium hyaluronate.

[0040] In the present application, the inulin mixture consists of short-chain inulin, medium-chain inulin, and long-chain inulin, and the mass ratio of the short-chain inulin, the medium-chain inulin, and the long-chain inulin is (0.6-1.8):(0.6-1.2):(1.6-3.6). For the mass ratio of (0.6-1.8):(0.6-1.2):(1.6-3.6), 0.6-1.8 can be 0.6, 0.7, 0.8, 0.9, 1.0, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, and any range between these values; 0.6-1.2 can be 0.6, 0.7, 0.8, 0.9, 1.0, 1.1, 1.2, and any range between these values; 1.6-3.6 can be 1.6, 1.7, 1.8, 1.9, 2.0, 2.1, 2.2, 2.3, 2.4, 2.5, 2.6, 2.7, 2.8, 2.9, 3, 3.1, 3.2, 3.3, 3.4, 3.5, 3.6, and any range between these values.

[0041] In some preferred embodiments, the mass ratio of the short-chain inulin, the medium-chain inulin, and the long-chain inulin is (0.6-1.8):(0.6-1.2):(1.8-3.0).

[0042] In some more preferred embodiments, the mass ratio of the short-chain inulin, the medium-chain inulin, and the long-chain inulin is 1.2:0.6:3.0, 1.5:0.6:2.7, 0.6:1.2:3.0, 1.2:1.2:2.4, or 1.8:1.2:1.8.

[0043] In the present application, the cosmetic composition further comprises grape seed extract and honokiol, and the mass ratio of the grape seed extract and the honokiol is (0.4-0.6):(0.05-0.10). For the mass ratio of (0.4-0.6):(0.05-0.10), 0.4-0.6 can be 0.4, 0.5, 0.6, and any range between these values; 0.05-0.10 can be 0.05, 0.06, 0.07, 0.08, 0.09, 0.10, and any range between these values.

[0044] In some preferred embodiments, the mass ratio of the grape seed extract and the honokiol is 0.4:0.05, 0.5:0.05, 0.6:0.05, 0.4:0.08, 0.5:0.08, 0.5:0.10, 0.6:0.08, 0.6:0.10, or 0.4:0.10.

[0045] In the present application, the cosmetic composition further comprises one or two or more of diosgenin, extract of artemisia, and licorice (root) extract.

[0046] The present application also provides a cosmetic preparation, wherein the cosmetic preparation comprises the above cosmetic composition and conventional adjuvants in the cosmetic field.

[0047] In the present application, the dosage form of the preparation is not limited, and those skilled in the art can select a suitable dosage form according to the prior art, including but not limited to cosmetic water, essence, skin care emulsion, skin care cream, facial cleanser, facial mask, skin care jelly, foundation, etc.

[0048] In the present application, the conventional adjuvants in the cosmetic field are not limited, and those skilled in the art can select according to the prior art, such as humectants, thickeners, emulsifiers, chelating agents, fatty alcohols, emollients, skin care agents, antioxidants, preservatives, fragrances, etc.

[0049] The present application also provides the use of the above cosmetic composition or cosmetic preparation in whitening.

[0050] Preparation Example 1 Sodium hyaluronate, yam extract, short-chain inulin, medium-chain inulin and long-chain inulin were added to rose water respectively, heated and stirred to 65°C, and then cooled to room temperature after complete dissolution. The content of each component was shown in Table 1 in mass percentage, and the balance was rose water.

[0051] Preparation Examples 2-5 and Comparative Examples 1-3 were different from Preparation Example 1 only in the content of each component, which was shown in Table 1.

[0052] Table 1

[0053] Preparation Example 6 Honokiol and grape seed extract (grape polyphenol) were dissolved in 1,3-butanediol and 1,2-hexanediol, and then added to 75°C rose water to dissolve completely. After stirring uniformly, sodium hyaluronate, short-chain inulin, medium-chain inulin, long-chain inulin, yam extract and EDTA-2Na were added in turn at 65°C, and stirred at 4500 rpm for 10 minutes until complete dissolution. When the temperature reached 45°C, grape seed extract (grape polyphenol), Artemisia capillaris extract, licorice (root) extract and diosgenin were added in turn, and stirred at 4500 rpm for 10 minutes. After adding p-hydroxyacetophenone, the mixture was stirred for another 10 minutes, and then cooled to room temperature. The content of each component was shown in Table 2 in mass percentage, and the balance was rose water.

[0054] Preparation Examples 7-14 and Comparative Examples 4-5 were different from Preparation Example 6 only in the content of each component, which was shown in Table 2.

[0055] Table 2

[0056] Example 1 Stability determination Take 10 g of the sample into a centrifuge tube, centrifuge at 4000 r / min for 30 min, and observe whether the sample has obvious differences in properties such as stratification, etc. If there are no obvious differences in properties such as stratification, etc., it indicates that the state is good.

[0057] Take 10 g of the sample into a sample bottle, and place it at 50±1℃, 40±1℃, 5±1℃, and -20±1℃, respectively, for 7 days. After recovery to room temperature, observe whether there are obvious differences in properties such as stratification, turbidity, discoloration, etc. compared with before the experiment. Take 10 g of the sample into a sample bottle, and place it at room temperature for 1 month. Observe whether the sample has phenomena such as stratification, turbidity, discoloration, etc.

[0058] Take 10 g of the sample into a sample bottle, and irradiate it under sunlight for 7 days. Observe whether there are phenomena such as stratification, turbidity, discoloration, etc.

[0059] Under different conditions, the sample has no obvious differences in properties such as stratification, turbidity, discoloration, etc. It indicates that the product has good stability.

[0060] This example tests the stability of Preparation Examples 6-14 and Comparative Examples 4-5. The results are shown in Table 3. As can be seen from the results, the preparation examples have good stability under different conditions.

[0061] Table 3

[0062] Example 2 Viscosity determination The viscosity of a cosmetic product is an important indicator for measuring its physical properties during the development stage of the product, and is a key detection item for quality control of the product. It can directly affect the stability of the product and the use experience of consumers. The determination of viscosity can be measured by a rotary viscometer according to different viscosities.

[0063] This example determines the viscosity of Preparation Examples 1-5 and Comparative Examples 1-3. The viscosity of each matrix is determined by an NDJ-5S rotary viscometer. The No. 1 rotor is selected, the rotation speed is 60 r / min, and the resistance generated by direct contact with the sample is used to calculate the viscosity. The viscosity values (mPa·s) of Preparation Examples 1-5 and Comparative Examples 1-3 are obtained, and the results are shown in Table 4.

[0064] Table 4

[0065] As can be seen from Table 4: Comparing Preparation Example 1 with Preparation Examples 2, 3, it can be seen that the viscosity increases when the long-chain inulin increases. Comparing Preparation Example 4 with Comparative Example 2, it can be seen that the viscosity increases when the medium-chain inulin increases, but the increase is smaller than that of the long-chain inulin. Comparing Preparation Example 4 with Comparative Example 3, it can be seen that the long-chain inulin determines the viscosity. Comparing Preparation Example 5 with Comparative Example 1, it can be seen that the short-chain inulin can also increase the viscosity to a certain extent; comparing Preparation Example 1 with Preparation Example 3, it can be seen that when the long-chain inulin is the same, the medium-chain inulin and the short-chain inulin have different viscosities, and when the ratio of short-chain inulin to medium-chain inulin is 2:1, the viscosity increases the most. In summary, when the total amount of inulin is ≤4.8% of the residence amount, the viscosity increases the most when the ratio of short-chain inulin to medium-chain inulin to long-chain inulin is 2:1:5, and the content of the short-chain and medium-chain inulins is largely retained.

[0066] Example 3 Tyrosinase Inhibitory Activity Assay Tyrosinase is a key enzyme in the process of skin melanin synthesis. Tyrosinase initiates the hydroxylation reaction of the substrate L-tyrosine (monophenol) to generate L-dopa (diphenol) in a PBS solution at 37°C and pH=6.8; then, L-dopa can be further oxidized to generate dopaquinone, which is further converted to dopachrome (with a maximum absorption peak at 475 nm), and the activity of tyrosinase can be determined by the change in absorbance (OD 475 ) of the solution. The reaction process usually takes 10-30 minutes, and the optimal temperature is 37°C.

[0067] In this example, the tyrosinase inhibitory activity of Preparation Examples 6-14 and Comparative Examples 4-5 was determined. 200 μL of sample solution, 200 μL of L-tyrosine solution (mass concentration 1 g / L), and 200 μL of PBS solution (pH=6.8) were sequentially added to a 1.5 ml centrifuge tube, vortexed, and incubated at 37°C for 10 min; then, 200 μL (200 U / mL) of substrate tyrosinase solution (mass concentration 0.4 g / L) was added, and the reaction was continued at 37°C for 30 min. With arbutin (Arb) as the positive control and PBS (pH=6.8) as the blank control, the absorbance A of the solution was determined at 475 nm, and the in vitro tyrosinase inhibition rate (%) was calculated. The formula for calculating the tyrosinase inhibition rate (%) is as follows:

[0068] In the formula: A sample : the absorbance of the sample solution + L-tyrosine solution + PBS solution + tyrosinase solution A sample control : the absorbance of the sample solution + L-tyrosine solution + PBS solution A blank : the absorbance of the L-tyrosine solution + PBS solution + tyrosinase solution A blank control: refers to the absorbance of L-tyrosine solution + PBS solution The results are shown in Table 5 below: Table 5

[0069] From the results of Table 5, it can be seen that in Preparation Example 6-8, it can be proved that when the proportion of honokiol is 0.5%, the inhibition rate of grape seed extract (grape polyphenol) with a proportion of 0.6% is improved, and the proportion is optimal; from Preparation Examples 7, 10 and 11, it can be seen that under the condition of 0.5% grape seed extract (grape polyphenol), 1.0% honokiol has the best inhibition rate on tyrosinase; from Preparation Examples 10-13, it can be seen that although the inhibition rate of 1.0% honokiol is slightly higher than that of 0.8% honokiol, the significant difference is not large; from Preparation Examples 9, 10 and 12, it can be proved that the proportion of 0.8% honokiol and 0.5% grape seed extract (grape polyphenol) is the optimal inhibition rate; by comparing Preparation Example 6, 9 and Preparation Example 14, it can be proved again that 0.8% honokiol is saturated in the formula. From Preparation Examples 6-14 and Comparative Examples 4 and 5, it can be seen that under the condition of the formula, honokiol and grape seed extract (grape polyphenol) have a synergistic effect on the inhibition rate, and the proportion of 0.8% honokiol and 0.5% grape seed extract (grape polyphenol) is the optimal synergistic inhibition rate in the formula.

[0070] The description of the present disclosure is given for the purpose of illustration and description, and is not exhaustive or limiting to the disclosed form. Many modifications and variations will be apparent to those of ordinary skill in the art. The embodiments are chosen and described in order to better illustrate the principles and practical application of the present disclosure, and to enable those of ordinary skill in the art to understand the present disclosure in order to design various embodiments with various modifications for specific use.

Claims

1. A composition of inulin for stabilizing and thickening a cosmetic system, wherein, The inulin composition comprises short-chain inulin, medium-chain inulin and long-chain inulin, and the mass ratio of the short-chain inulin, medium-chain inulin and long-chain inulin is (0.6-1.8):(0.6-1.2):(1.6-3.6).

2. The composition of claim 1, wherein, The mass ratio of the short-chain inulin, medium-chain inulin and long-chain inulin is (0.6-1.8):(0.6-1.2):(1.8-3.0).

3. Use of a inulin composition for stabilizing, thickening a cosmetic system, wherein, The inulin composition comprises short-chain inulin, medium-chain inulin and long-chain inulin, and the mass ratio of the short-chain inulin, medium-chain inulin and long-chain inulin is (0.6-1.8):(0.6-1.2):(1.6-3.6).

4. Use according to claim 3, wherein, The mass ratio of the short-chain inulin, medium-chain inulin and long-chain inulin is (0.6-1.8):(0.6-1.2):(1.8-3.0).

5. A composition for inhibiting the activity of a tyrosinase, wherein, The composition comprises grape seed extract and honokiol, and the mass ratio of the grape seed extract and honokiol is (0.4-0.6):(0.05-0.10).

6. The composition of claim 5, wherein, The grape seed extract is selected from one or more of grape polyphenol, proanthocyanidin, resveratrol, anthocyanin, catechin and epicatechin; Preferably, the grape seed extract is grape polyphenol.

7. Use of a composition comprising grape seed extract and honokiol for inhibiting tyrosinase activity, wherein, The mass ratio of the grape seed extract and honokiol is (0.4-0.6):(0.05-0.10).

8. Use according to claim 7, wherein, The grape seed extract is selected from one or more of grape polyphenol, proanthocyanidin, resveratrol, anthocyanin, catechin and epicatechin; Preferably, the grape seed extract is grape polyphenol.

9. A cosmetic composition comprising yam extract, inulin mixture, sodium hyaluronate.

10. The cosmetic composition according to claim 9, wherein, The inulin mixture is composed of short-chain inulin, medium-chain inulin and long-chain inulin, and the mass ratio of the short-chain inulin, medium-chain inulin and long-chain inulin is (0.6-1.8):(0.6-1.2):(1.6-3.6).

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