Composition for improving skin state of pressure muscle as well as preparation method and application of composition

Abstract

The invention relates to the technical field of skin care products, and particularly discloses a composition for improving the skin state of pressure muscles as well as a preparation method and application of the composition. According to the application, the composition for improving the skin state of the pressure muscle is formed by the combined action of the guaiazulene flexible body, the tephrosia rubescens seed extract, the nicotinamide and the camellia exosome; the guaiazulene flexible body and the tephrosia rubescens seed extract can jointly inhibit a TRPV1 / P substance pathway to relieve neurogenic causalgia, the nicotinamide and the camellia exosome can block alpha-MSH mediated hyperpigmentation and repair a barrier to reduce TEWL, and meanwhile, the four components can activate collagen regeneration and resist external stimulation; neural calming, black fading, barrier repairing and anti-aging are synchronously realized, and HPA axis cascade injury is blocked, so that repeated deterioration of symptoms is avoided.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of skin care, in particular to a composition for improving the skin state of pressure muscles, a preparation method and application thereof. BACKGROUND

[0002] Pressure muscles are a skin syndrome caused by the abnormal release of stress hormones such as cortisol due to the activation of the hypothalamic-pituitary-adrenal (HPA) axis through the sustained mental stress (such as work load, emotional anxiety) of modern high-pressure people. Its core manifestations are: (1) neurogenic sensitivity: stress mediators such as P substance and corticotropin-releasing hormone (CRH) stimulate cutaneous sensory nerve endings, causing burning, stinging and sudden redness; (2) pigment disorder: cortisol promotes the release of melanocyte-stimulating hormone (alpha-MSH), activates tyrosinase and accelerates melanin synthesis, forming pressure stains; (3) barrier function damage: cortisol degrades ceramide and cholesterol in the stratum corneum, destroys the "brick wall structure", causes increased trans-epidermal water loss (TEWL) and decreased water retention capacity, and the skin presents a "oily outside and dry inside" state; (4) aging and relaxation: stress hormones activate matrix metalloproteinases (MMP-1 / 9), degrade dermal collagen and elastic fibers, and inhibit fibroblast activity, accelerating wrinkle formation and skin relaxation.

[0003] Current skin care products do not have products and ingredients specifically for pressure muscle skin care. For the multi-channel combined damage caused by stress, including neurosensitivity, pigment disorder, barrier collapse, collagen collapse, there is a lack of systematic and synergistic intervention, which cannot simultaneously block the cascade reaction triggered by the activation of the HPA axis, resulting in repeated exacerbation of symptoms. And the existing products are difficult to achieve long-term, dynamic and full-dimensional protection. SUMMARY

[0004] The purpose of the present application is to overcome the shortcomings of the prior art and provide a composition for improving the skin state of pressure muscles, a preparation method and application thereof.

[0005] To achieve the above purpose, the technical solution adopted by the present application is:

[0006] The present application provides a composition for improving the skin state of pressure muscles, which comprises the following components in parts by weight:

[0007] 0.1-1 parts of guaiazul flexible body, 0.1-5 parts of Albizia Lebbeck seed extract, 0.1-5 parts of nicotinamide and 0.01-3 parts of Camellia japonica exosome;

[0008] The guaiazul flexible body comprises two phases with the following mass percentage: oil phase 15-35% and water phase 65%-85%;

[0009] The oil phase comprises guaiazulene, a solubilizing carrier, an emulsifier, and a stabilizer.

[0010] The water phase comprises a polyol and deionized water.

[0011] The mass percentage of guaiazulene in the guaiazulene flexible body is not less than 2%.

[0012] In the above technical solution, guaiazulene is a blue-purple sesquiterpene compound extracted from the chrysanthemum plant mother chrysanthemum and guaiac wood, which has unique anti-inflammatory and nerve regulation activity. The five-membered ring and seven-membered conjugated system in the molecular structure of guaiazulene can efficiently capture free radicals, reduce the release of substance P by inhibiting the TRPV1 ion channel (transient receptor potential vanilloid subtype 1), and block neurogenic inflammation signaling, thereby rapidly relieving the burning pain and redness of the stress muscle.

[0013] Greyhairs soybean seeds are derived from leguminous plants and are rich in isoflavones (such as rotenone and greyhairs soybean phenol) and triterpenoid saponins. Its core mechanism lies in bidirectional regulation of the "nerve-skin axis": on the one hand, by inhibiting the hypothalamic-pituitary-adrenal (HPA) axis activity, it reduces the release of cortisol, thereby blocking stress-induced neurogenic inflammation and relieving redness, burning pain, and itching; on the other hand, some of its polysaccharide and flavonoid active ingredients can stimulate keratinocytes to release β-endorphins, which, by binding to skin opioid receptors, inhibit inflammatory mediators such as substance P, while promoting barrier repair and pigment metabolism balance.

[0014] Nicotinamide is the active form of vitamin B3, which repairs the barrier and prevents pigment deposition through a dual pathway. First, it increases the expression of ceramide synthase, promoting the synthesis of ceramide subtypes III and VI in the stratum corneum, reducing the trans-epidermal water loss (TEWL) by 42%. Second, nicotinamide can inhibit the transfer of melanin bodies to keratinocytes, reducing the area of pigment deposition-type spots.

[0015] Camellia flower exosomes are nanoscale vesicles (30-150 nm in diameter) isolated from camellia flower stem cell culture medium, rich in small molecule RNAs (such as miR166a-3p) and growth factors (TGF-β). miRNA activates the TGF-β / Smad pathway in fibroblasts, upregulating collagen type I / III gene expression. The exosome phospholipid bilayer fuses with the keratinocyte membrane, repairing the "brick wall structure" and increasing the water content of the stratum corneum. Camellia flower exosomes can protect active substances from enzymatic degradation, increasing the transdermal rate.

[0016] The present application forms a composition for improving the stress skin state through the combined action of guaiazulene flexible body, milk vetch seed extract, nicotinamide and camellia flower exosome. Guaiazulene flexible body and milk vetch seed extract can jointly inhibit the TRPV1 / P substance pathway to relieve neurogenic burning pain, nicotinamide and camellia flower exosome can block the α-MSH mediated pigmentation and repair the barrier to reduce TEWL, and the four components can also activate collagen regeneration, resist external stimulation, achieve the effects of nerve calming, melatonin, barrier repair and anti-aging, synchronously block the HPA axis cascade damage, and avoid repeated deterioration of symptoms.

[0017] Further, guaiazulene has the defects of poor water solubility, photosensitivity discoloration and low skin permeability in traditional applications. The guaiazulene flexible body of the present application uses caprylic / capric triglyceride as a solubilizing carrier to break the hydrophobic property of guaiazulene, greatly improve its solubility in the oil phase, and the solubilizing carrier cooperates with sorbitan palmitate stabilizer to form a nanoscale lipid structure, which significantly improves the solubility and compatibility of guaiazulene, so that it can be stably integrated into the water phase and avoid the loss of activity caused by light decomposition. At the same time, the lipid bilayer structure formed by the oil phase and the water phase greatly enhances the transdermal absorption rate, promotes the efficient delivery of guaiazulene to the deep layer of the skin, targets the inhibition of the TRPV1 / P substance pathway, quickly relieves neurogenic burning pain and redness, and realizes the dual breakthrough of bioavailability and long-acting soothing effect.

[0018] The water phase of the present application includes polyhydric alcohol and deionized water. The polyhydric alcohol has both moisturizing and stabilizing effects. On the one hand, it provides moisture to the skin and enhances the skin feel of the preparation; on the other hand, it adjusts the osmotic pressure of the water phase to help maintain the dispersion stability of the oil phase nanoparticles and avoid particle agglomeration.

[0019] As a preferred embodiment of the composition described in the present application, the composition includes the following components in the following weight fractions:

[0020] Guaiazulene flexible body 0.3-0.8 parts, milk vetch seed extract 0.3-3 parts, nicotinamide 0.5-3 parts and camellia flower exosome 0.1-2 parts.

[0021] The guaiazulene flexible body, milk vetch seed extract, nicotinamide and camellia flower exosome of the present application preferably have the above weight fraction range, which can better improve the stress skin state, has the effects of nerve calming, melatonin, barrier repair and anti-aging, synchronously blocks the HPA axis cascade damage, and avoids repeated deterioration of symptoms.

[0022] As a preferred embodiment of the composition described in the present application, the composition includes the following components in the following weight fractions:

[0023] Guaiazulene flexible body 0.5 parts, milk vetch seed extract 0.5 parts, nicotinamide 1 part and camellia flower exosome 0.2 parts.

[0024] When the composition of this application is preferably formulated as described above, it can simultaneously block the cascade reaction triggered by HPA axis activation and inhibit the repeated deterioration of symptoms in response to the lack of systematic and synergistic intervention for stress-induced damage involving multiple pathways, including nerve sensitivity, pigmentary disorders, barrier collapse, and collagen breakdown; and it can achieve long-lasting, dynamic, and all-dimensional protection.

[0025] As a preferred embodiment of the composition described in this application, the emulsifier comprises polyglycerol-10 oleate and polyglycerol-6 laurate; the stabilizer comprises sorbitan palmitate; the solubilizing carrier comprises caprylic / capric triglyceride or isopropyl myristate; and the polyol comprises glycerol.

[0026] Traditional guaiac is a hydrophobic component, which has drawbacks such as poor water solubility, photosensitivity and easy discoloration, and low skin permeability. This application uses caprylic / capric triglyceride or isopropyl myristate as a solubilizing carrier, which can completely dissolve guaiac. The solubilizing carrier, together with stabilizers and emulsifiers (reduces the interfacial tension between the oil phase and the water phase, so that the oil phase can be uniformly dispersed in the water phase, avoids the two phases from separating, and ensures the uniformity and stability of the flexible body), makes the oil phase form a nanoscale lipid structure and disperse it in the water phase. Guaiac has no compatibility problems such as separation and precipitation, and avoids the loss of activity caused by light decomposition, which greatly broadens the application range of guaiac.

[0027] More preferably, the solubilizing carrier is caprylic / capric triglyceride;

[0028] The sorbitan palmitate is sorbitan palmitate-40 or sorbitan palmitate-80.

[0029] In the technical solution of this application, when the solubilizing carrier is preferably of the above-mentioned type, it can better dissolve guaiazoline; when the stabilizer is preferably of the above-mentioned type, it can better synergize with the solubilizing carrier and avoid the loss of activity caused by the light decomposition of guaiazoline.

[0030] As a preferred embodiment of the composition described in this application, the weight ratio of guaiac:solubilizer:emulsifier:stabilizer is (1-5):(5-15):(8-20):(1-5);

[0031] And / or, the weight ratio of the polyol to deionized water is polyol to deionized water = (10-30): (30-75).

[0032] As a preferred embodiment of the composition described in this application, the weight ratio of guaiac:solubilizer:emulsifier:stabilizer is (1.5-2):(7.5-10):(12-17):(3-4);

[0033] And / or, the weight ratio of the polyol to deionized water is polyol to deionized water = (15-20):(47-61).

[0034] More preferably, the mass ratio of guaiac to stabilizer is 1:2; and the mass ratio of guaiac to solubilizing carrier is 1:5.

[0035] When the guaiac, solubilizing carrier, emulsifier, and stabilizer are used in the above-mentioned mass ratio range in this application, the solubilizing carrier and stabilizer synergistically form a nanoscale lipid structure, which significantly improves the solubility and compatibility of guaiac, allowing the prepared oil phase to be stably dissolved in the aqueous phase and avoiding photodecomposition that would lead to the loss of guaiac activity. At the same time, the nanoemulsion formed by the oil and aqueous phases greatly enhances the transdermal absorption rate of guaiac, promotes the efficient delivery of guaiac to the deep layers of the skin, targets and inhibits the TRPV1 / P pathway, and rapidly relieves neurogenic burning pain and redness, achieving a dual breakthrough in bioavailability and long-lasting soothing effect.

[0036] As a preferred embodiment of the composition described in this application, the method for preparing the guaiac flexible body includes the following steps:

[0037] S1. Guaifenesin and solubilizing carrier are mixed evenly, then mixed with emulsifier and stabilizer and heated to dissolve to obtain oil phase; polyol and deionized water are mixed and heated to obtain aqueous phase;

[0038] S2. Pour the oil phase into the aqueous phase, shear and homogenize to form a primary emulsion, and then homogenize the primary emulsion under high pressure to obtain a guaiac flexible body.

[0039] This application employs a thermal melting-high pressure homogenization method to prepare guaiac flexible bodies. A solubilizing carrier and a synergistic stabilizer are used to form nanoscale flexible bodies, which significantly improves the solubility and compatibility of guaiac. The prepared oil phase can be stably integrated into the aqueous phase, and the loss of activity caused by photodegradation of guaiac is avoided. At the same time, the lipid bilayer structure greatly enhances the transdermal absorption rate, promotes the efficient delivery of guaiac to the deep layers of the skin, targets and inhibits the TRPV1 / P pathway, and quickly relieves neurogenic burning pain and redness, achieving a dual breakthrough in bioavailability and long-lasting soothing effect.

[0040] In a preferred embodiment of the composition described in this application, in step S1, guaiac and solubilizing carrier are mixed evenly, and then mixed with emulsifier and stabilizer and heated to 70-75°C to dissolve and obtain oil phase; polyol and deionized water are mixed and heated to 80-85°C to obtain aqueous phase.

[0041] In a preferred embodiment of the composition described in this application, in step S2, the rotation speed for shearing homogenization is 5000-8000 rpm, and the time is 1-5 min;

[0042] And / or, the pressure for high-pressure homogenization is 600–1200 bar, the rotation speed is 8000–15000 rpm, and the number of homogenization cycles is 3–5.

[0043] This application utilizes thermal melting-high pressure homogenization technology to prepare guaiac flexible tissue, which has advantages such as good water solubility, photosensitivity and resistance to discoloration, and high skin permeability.

[0044] This application also provides the use of the above composition in the preparation of cosmetics for the care of stressed skin.

[0045] This application also provides a cosmetic for the care of stressed skin, the cosmetic comprising a face cream;

[0046] The face cream comprises the following components by weight percentage:

[0047] The above composition contains 1% to 5% thickener, 0.1% to 2% humectant, 0.5% to 5% emulsifier, 1% to 10% pH adjuster, 0.01% to 0.3% preservative, and the balance is deionized water.

[0048] Preferably, the cosmetic includes at least one of the following: toner, lotion, cream, mask, lotion, essential oil, and spray.

[0049] Preferably, the thickener includes at least one of xanthan gum, carbomer, ammonium acryloyldimethyl taurate / VP copolymer, and sclerotium gum; the humectant includes at least one of glycerin, D-panthenol, vitamin B5, 1,3-butanediol, 1,2-hexanediol, 1,3-propanediol, sodium hyaluronate, tremella polysaccharide, trehalose, betaine, allantoin, and hyaluronic acid; the emulsifier includes at least one of caprylic / capric triglyceride, C14-22 alcohol, C12-20 alkyl glucoside, cetearyl glucoside, isononyl isononanoate, pentaerythritol tetraester, polydimethylsiloxane, stearyl alcohol, hydroxystearic acid, polymethyl silsesquioxane, pentaerythritol distearate, and sucrose stearate; the pH adjuster includes at least one of arginine, disodium ethylenediaminetetraacetate, tromethamine, and disodium EDTA; and the preservative includes at least one of p-hydroxyacetophenone and polyols.

[0050] This application also provides a method for preparing a face cream for stress-induced skin care, comprising the following steps:

[0051] (1) Mix the humectant and thickener with water and stir. Heat to 85°C and homogenize at 13000 rpm for 4 min to obtain pre-prepared component A.

[0052] (2) After mixing the emulsifier and heating it to 85°C, pour it into the pre-prepared A component at 85°C and homogenize it at 13000 rpm for 3-4 minutes to obtain the pre-prepared face cream base.

[0053] (3) Mix the preservatives and heat them to 60°C to melt them, to obtain a pre-preservative;

[0054] (4) After cooling the pre-made face cream base to 60°C, add the pre-made preservative at 3000 rpm and stir to mix. Then cool it down to below 45°C, add the above composition and continue stirring for 8 minutes. Finally, add the pH adjuster to adjust the pH to 5.5-6.0, then stop stirring, discharge the material, and obtain the face cream.

[0055] Compared with the prior art, this application has the following beneficial effects:

[0056] This application provides a composition for improving the condition of stressed skin, its preparation method, and its application. The composition for improving the condition of stressed skin is formed by the combined action of guaiac soft tissue, edamame seed extract, nicotinamide, and camellia exosomes. Guaiac soft tissue and edamame seed extract can jointly inhibit the TRPV1 / P substance pathway to relieve neurogenic burning pain. Nicotinamide and camellia exosomes can block α-MSH-mediated pigmentation and repair the skin barrier to reduce TEWL. At the same time, the four components can also activate collagen regeneration and resist external stimuli, achieving simultaneous blocking of the HPA axis cascade damage through four pathways: "nerve calming - melanin reduction - barrier repair - anti-aging", thus avoiding repeated worsening of symptoms. Furthermore, guaiacine has drawbacks in traditional applications, including poor water solubility, photosensitivity, easy discoloration, and low skin penetration. The guaiacine flexible body of this application uses caprylic / capric triglycerides as a solubilizing carrier, overcoming the hydrophobic properties of guaiacine and significantly improving its solubility in the oil phase. The solubilizing carrier, in conjunction with sorbitan palmitate stabilizer, forms a nanoscale lipid structure, significantly enhancing the solubility and compatibility of guaiacine, allowing it to stably integrate into the aqueous phase and avoiding photodegradation leading to loss of activity. Simultaneously, the lipid bilayer structure formed by the oil and aqueous phases greatly enhances transdermal absorption, promoting efficient delivery of guaiacine to the deep layers of the skin, targeting and inhibiting the TRPV1 / P pathway, and rapidly relieving neurogenic burning pain and redness, achieving a dual breakthrough in bioavailability and long-lasting soothing effect. Attached Figure Description

[0057] Figure 1 This illustrates the dissolution of guaiac flexible tissue in water.

[0058] Figure 2 The improvement in cell scratches is shown in Example 1 and Comparative Example 1;

[0059] Figure 3 The improvement of facial redness after 0 and 14 days of use is shown in Application Example 1 and the blank application example. Detailed Implementation

[0060] To better illustrate the purpose, technical solution, and advantages of this application, the following description will be provided in conjunction with the accompanying drawings and specific embodiments.

[0061] In the following examples and comparative examples, unless otherwise specified, the experimental methods used are conventional methods, and the materials and reagents used are commercially available unless otherwise specified. Furthermore, the raw materials used in each parallel experiment are the same.

[0062] In the following embodiments and comparative examples:

[0063] The edamame seed extract was purchased from Givaudan, under the brand name [Brand Name - missing in original text]. Niacinamide was purchased from DSM under the trade name Niacinamide PC; camellia exosomes were purchased from Shandong Huayi Biotechnology Group Co., Ltd.

[0064] Schisandra chinensis extract was purchased from Draco, under the trade name Schisandra chinensis extract; rose exosomes were purchased from Shandong Huayi Biotechnology Group Co., Ltd., under the trade name... Rose extract.

[0065] The components and weight proportions of the guaiac flexible body described in this application are shown in Table 1 below. The preparation method of the guaiac flexible body includes the following steps:

[0066] S1. Guaifenesin and solubilizing carrier are mixed evenly, then mixed with emulsifier and stabilizer and heated to 75°C to dissolve and obtain oil phase; polyol and deionized water are mixed and heated to 85°C to obtain aqueous phase;

[0067] S2. Pour the oil phase into the aqueous phase and shear homogenize at 6000 rpm for 3 minutes to form a primary emulsion. The primary emulsion is then homogenized under high pressure at 800 bar and 12000 rpm for 3 cycles to obtain a guaiac flexible body.

[0068] The total weight parts of guaiac wood flexible body in Table 1 are 100 parts. A schematic diagram of the dissolution of guaiac wood flexible body in water is shown below. Figure 1 As shown.

[0069] Table 1

[0070]

[0071]

[0072] This application provides a composition for improving the condition of stressed skin, the components and weight proportions of which are selected as follows.

[0073] The method for preparing the composition for improving the condition of stressed skin is as follows: Guaiac soft tissue, edamame seed extract, nicotinamide and camellia exosomes are mixed evenly to obtain the composition for improving the condition of stressed skin.

[0074] When preparing a composition for improving the condition of stressed skin, if the relevant component is not available, it can be omitted; if other components are available, they should be added together and mixed thoroughly.

[0075] Examples 1-10 and Comparative Examples 1-10, a composition for improving the state of stress skin

[0076] Examples 1-10 and Comparative Examples 1-10 provide a composition for improving the condition of stressed skin, as detailed below:

[0077] Example 1:

[0078] The composition for improving the condition of stressed skin comprises the following components in parts by weight:

[0079] 0.5 parts guaiac flexures, 0.5 parts edamame seed extract, 1 part nicotinamide and 0.2 parts camellia exosomes.

[0080] Example 2:

[0081] The composition for improving the condition of stressed skin comprises the following components in parts by weight:

[0082] 1 part guaiac soft tissue, 0.1 part edamame seed extract, 5 parts nicotinamide and 0.01 part camellia exosomes.

[0083] Example 3:

[0084] The composition for improving the condition of stressed skin comprises the following components in parts by weight:

[0085] 0.1 parts guaiac soft tissue, 1.5 parts edamame seed extract, 0.1 parts nicotinamide and 3 parts camellia exosomes.

[0086] Example 4:

[0087] The composition for improving the condition of stressed skin comprises the following components in parts by weight:

[0088] 0.3 parts guaiac flexures, 1.3 parts edamame seed extract, 0.5 parts nicotinamide and 0.1 parts camellia exosomes.

[0089] Example 5:

[0090] The composition for improving the condition of stressed skin comprises the following components in parts by weight:

[0091] 0.8 parts guaiac flexures, 0.3 parts edamame seed extract, 3 parts nicotinamide and 2 parts camellia exosomes.

[0092] Example 6:

[0093] The composition for improving the condition of stressed skin comprises the following components in parts by weight:

[0094] 0.5 parts guaiac flexible body 2, 0.5 parts edamame seed extract, 1 part nicotinamide and 0.2 parts camellia exosomes.

[0095] Example 7:

[0096] The composition for improving the condition of stressed skin comprises the following components in parts by weight:

[0097] 0.5 parts guaiac soft tissue 3, 0.5 parts edamame seed extract, 1 part nicotinamide and 0.2 parts camellia exosomes.

[0098] Example 8:

[0099] The composition for improving the condition of stressed skin comprises the following components in parts by weight:

[0100] 0.5 parts guaiac soft tissue, 0.5 parts edamame seed extract, 1 part nicotinamide and 0.2 parts camellia exosomes.

[0101] Example 9:

[0102] The composition for improving the condition of stressed skin comprises the following components in parts by weight:

[0103] 0.5 parts guaiac flexures, 0.5 parts edamame seed extract, 1 part nicotinamide and 0.2 parts camellia exosomes.

[0104] Example 10:

[0105] The composition for improving the condition of stressed skin comprises the following components in parts by weight:

[0106] 0.5 parts guaiac flexible body 6, 0.5 parts edamame seed extract, 1 part nicotinamide and 0.2 parts camellia exosomes.

[0107] Example 11:

[0108] The composition for improving the condition of stressed skin comprises the following components in parts by weight:

[0109] 0.5 parts guaiac flexible body 7, 0.5 parts edamame seed extract, 1 part nicotinamide and 0.2 parts camellia exosomes.

[0110] Example 12:

[0111] The composition for improving the condition of stressed skin comprises the following components in parts by weight:

[0112] 0.5 parts guaiac flexible body 8, 0.5 parts edamame seed extract, 1 part nicotinamide and 0.2 parts camellia exosomes.

[0113] Example 13:

[0114] The composition for improving the condition of stressed skin comprises the following components in parts by weight:

[0115] 0.5 parts guaiac flexible body 9, 0.5 parts edamame seed extract, 1 part nicotinamide and 0.2 parts camellia exosomes.

[0116] Example 14:

[0117] The composition for improving the condition of stressed skin comprises the following components in parts by weight:

[0118] 0.5 parts guaiac flexible body 10, 0.5 parts edamame seed extract, 1 part nicotinamide and 0.2 parts camellia exosomes.

[0119] Example 15:

[0120] The composition for improving the condition of stressed skin comprises the following components in parts by weight:

[0121] 0.5 parts guaiac flexible body 11, 0.5 parts edamame seed extract, 1 part nicotinamide and 0.2 parts camellia exosomes.

[0122] Example 16:

[0123] The composition for improving the condition of stressed skin comprises the following components in parts by weight:

[0124] 0.5 parts guaiac flexible body 12, 0.5 parts edamame seed extract, 1 part nicotinamide and 0.2 parts camellia exosomes.

[0125] Comparative Example 1:

[0126] Compared with Example 1, Comparative Example 1 did not use guaiac flexible body 1, but directly used 0.5 parts of guaiac. The remaining components and their weight parts were the same as those in Example 1.

[0127] Comparative Example 2:

[0128] Compared with Example 1, Comparative Example 2 does not contain guaiac flexible body 1, and the remaining components and their weight parts are the same as those in Example 1.

[0129] Comparative Example 3:

[0130] Compared with Example 1, Comparative Example 3 does not contain edamame seed extract, and the remaining components and their weight parts are the same as those in Example 1.

[0131] Comparative Example 4:

[0132] Compared with Example 1, Comparative Example 4 does not contain nicotinamide, and the remaining components and their weight parts are the same as those in Example 1.

[0133] Comparative Example 5:

[0134] Compared with Example 1, Comparative Example 5 did not contain camellia exosomes, but the remaining components and their weight proportions were the same as those in Example 1.

[0135] Comparative Example 6:

[0136] Compared with Example 1, Comparative Example 6 does not contain guaiac flexible body 1 and edamame seed extract, while the remaining components and their weight parts are the same as those in Example 1.

[0137] Comparative Example 7:

[0138] Compared with Example 1, Comparative Example 7 does not contain guaiac flexible body 1 and camellia exosomes, and the remaining components and their weight parts are the same as those in Example 1.

[0139] Comparative Example 8:

[0140] Compared with Example 1, Comparative Example 8 did not contain edamame seed extract and camellia exosomes, while the remaining components and their weight proportions were the same as in Example 1.

[0141] Comparative Example 9:

[0142] Compared with Example 1, the weight of guaiac flexible body 1 in Comparative Example 9 is 5 parts, and the remaining components and their weight parts are the same as in Example 1.

[0143] Comparative Example 10:

[0144] Compared with Example 1, the weight of guaiac flexible body 1 in Comparative Example 10 is 0.05 parts, and the remaining components and their weight parts are the same as those in Example 1.

[0145] Comparative Example 11:

[0146] Compared with Example 1, the weight parts of the soybean seed extract in Comparative Example 11 were 8 parts, while the remaining components and their weight parts were the same as in Example 1.

[0147] Comparative Example 12:

[0148] Compared with Example 1, the weight of nicotinamide in Comparative Example 12 was 8 parts, while the weight of the remaining components was the same as in Example 1.

[0149] Comparative Example 13:

[0150] Compared with Example 1, the weight fraction of camellia exosomes in Comparative Example 13 was 5 parts, and the remaining components and their weight fractions were the same as in Example 1.

[0151] Comparative Example 14:

[0152] Compared with Example 1, Comparative Example 14 used Schisandra chinensis extract instead of Edamame seed extract, and the remaining components and their weight parts were the same as in Example 1.

[0153] Comparative Example 15:

[0154] Compared with Example 1, Comparative Example 15 used tranexamic acid instead of nicotinamide, and the remaining components and their weight parts were the same as in Example 1.

[0155] Comparative Example 16:

[0156] Compared with Example 1, Comparative Example 15 used rose exosomes instead of camellia exosomes, and the remaining components and their weight parts were the same as in Example 1.

[0157] Application Examples 1-18, Comparative Application Examples 1-16, A face cream for stress-induced skin care

[0158] Application Examples 1-18, Comparative Application Examples 1-16, and a blank example provide a face cream for stress-induced skin care. The components (mass percentage) of the face cream are shown in Table 2. Although Table 2 illustrates the compositions used in the corresponding examples / comparative examples, for clarity, illustrative examples are provided here. For instance, Application Example 1 uses the composition of Example 1, Application Example 2 uses the composition of Example 2, and so on. Comparative Application Example 1 uses the composition of Comparative Example 1, Comparative Application Example 2 uses the composition of Comparative Example 2, and so on. Application Examples 17-18 use the composition of Example 1.

[0159] Table 2

[0160]

[0161] This application provides a method for preparing a face cream, the method comprising the following steps:

[0162] (1) Mix the humectant and thickener with water and stir. Heat to 85°C and homogenize at 13000 rpm for 4 min to obtain pre-prepared component A.

[0163] (2) After mixing the emulsifier and heating it to 85°C, pour it into the pre-prepared A component at 85°C and homogenize it at 13000 rpm for 3-4 minutes to obtain the pre-prepared face cream base.

[0164] (3) Mix the preservatives and heat them to 60°C to melt them, to obtain a pre-preservative;

[0165] (4) After cooling the pre-made face cream base to 60°C, add the pre-made preservative at 3000 rpm and stir to mix. Then cool it down to below 45°C, add the composition and continue stirring for 8 minutes. Finally, add the pH adjuster to adjust the pH to 5.5-6.0, then stop stirring, discharge the material, and obtain the face cream.

[0166] Test Example 1, experiment of the cell repair effect of the composition under the stress of cortisol

[0167] The scratch assay is an effective way to evaluate the skin barrier repair capacity. Cortisol is a typical "stress factor" that inhibits the skin's self-repair. By observing cell migration and regeneration after scratching, the ability of the composition to repair damaged cell barriers can be directly reflected. In the experiment, by comparing cell healing speed, the impact of different treatments on skin repair can be assessed.

[0168] The test samples of the compositions of Examples 1-16 and the test samples of the compositions of Comparative Examples 1-16 were tested according to the following steps, and the results are shown in Table 3.

[0169] Human keratinocytes (HaCaT) resuscitation (Guangzhou Genio Biotechnology Co., Ltd.) were tested under the following conditions: incubator temperature 37±1℃, humidity 90±5%, and carbon dioxide 5±1%. Cells were cultured and treated according to groupings, followed by testing. Specifically, the test utilized two-well cell healing slides, and the testing method is as follows:

[0170] Test substance preparation: Dilute the composition (Examples 1-16, Comparative Examples 1-16) to 0.05% using DMEM cell culture medium, and record it as the sample solution; refrigerate.

[0171] (1) Take out the 12-well plate, use sterile forceps to fix the 2-well wound healing inserts in the middle of the corresponding wells, and seed the cell suspension into the 12-well plate with the 2-well wound healing inserts at a density of 6 × 10⁶ cells per well. 5 Add 1000 μL of DMEM high glucose medium (Gibco) containing 10% fetal bovine serum to each well and incubate for 24 h.

[0172] (2) Drug administration: 100 μL of culture medium containing 0.05% of the test sample and 250 μg / mL of cortisol solution was added to the sample group, the insert was removed, and the culture was continued for 24 h.

[0173] (3) Photographs: The cell scratches of each group were photographed under a microscope at 0h and 24h, and the area of ​​the scratches was measured.

[0174] The skin barrier repair ability of the samples was represented by the cell scratch healing rate, which was calculated as follows, and the results are shown in Table 3:

[0175] Cell healing rate (%) = (cell scratch area) 0h -Cell scratch area 24h ) / cell scratch area 0h ×100%.

[0176] Table 3

[0177]

[0178]

[0179]

[0180] As shown in Table 3 and Figure 2 As shown, the compositions prepared using Examples 1-16 for improving the condition of stressed skin can repair cells under cortisol stress, with a high cell healing rate, reaching up to 99.2%, effectively repairing the damaged barrier and thus repairing the skin.

[0181] The compositions in Examples 1-5 used different weight parts of guaiac flexible body 1, soybean seed extract, nicotinamide, and camellia exosomes. The cell healing rate of the composition in Example 1 was better than that in Examples 4-5, and Examples 4-5 were better than Examples 2-3. This indicates that the preferred weight parts of guaiac flexible body 1 (0.3-0.8 parts), soybean seed extract (0.3-3 parts), nicotinamide (0.5-3 parts), and camellia exosomes (0.1-2 parts) can better repair cells under cortisol stress and effectively repair damaged barriers.

[0182] Examples 1 and 6-16 used different guaiac flexible bodies, and the component weight parts of Examples 1, 6-9 and 15-16 were different. Examples 15-16 used excess caprylic / capric triglyceride and sorbitan palmitate-40. The cell repair effect of the compositions of Examples 1 and 8-9 under cortisol pressure was better than that of Examples 6-7 and Examples 15-16, indicating that the appropriate weight ratio of guaiac, solubilizing carrier, emulsifier and stabilizer can better improve the effect of repairing damaged barriers.

[0183] Examples 1, 10, and 11 used different solubilizing carriers. Example 1 used caprylic / capric triglyceride as a solubilizing carrier, while Examples 10 and 11 used isopropyl myristate and ethylhexyl palmitate as solubilizing carriers, respectively. The composition of Example 1 showed better cell repair effect under cortisol pressure than Examples 10 and 11, indicating that using caprylic / capric triglyceride as a solubilizing carrier can better improve the repair effect of damaged barrier.

[0184] Examples 1 and 12 used different emulsifiers. Example 1 used polyglycerol-10 oleate and polyglycerol-6 laurate as emulsifiers, while Example 12 used hydrogenated lecithin as an emulsifier. The composition of Example 1 showed better cell repair performance under cortisol pressure than that of Example 12, indicating that using polyglycerol-10 oleate and polyglycerol-6 laurate as emulsifiers can better improve the repair effect on damaged barriers. Using hydrogenated lecithin as an emulsifier in this system may lead to oil phase precipitation, decreased viscosity, and inactivation of active ingredients, thus weakening the effect of repairing damaged barriers.

[0185] Examples 1 and 13-14 used different types of sorbitan palmitate. Example 1 used sorbitan palmitate-40 as a stabilizer, while Examples 13 and 14 used sorbitan palmitate-80 and sorbitan palmitate-20 as stabilizers, respectively. Sorbitan palmitate-40 and sorbitan palmitate-80 have longer hydrophobic carbon chains, which can bring steric stability, crystallization inhibition ability and interfacial film strength. Therefore, Examples 1 and 13 have better effects in repairing damaged barriers.

[0186] The composition of Comparative Example 1 uses guaiac, which has poor water solubility, is easily photosensitive and discolored, and has low skin penetration, resulting in poor effect of the composition in repairing damaged cell barriers.

[0187] The compositions of Comparative Examples 2–8 lacked at least one or two of the following: guaiac soft tissue, edamame seed extract, nicotinamide, and camellia exosomes. Comparative Examples 14–16 used other substances to replace edamame seed extract, nicotinamide, and camellia exosomes, and the cell healing rate was poor in all of them. This indicates that compositions with specific components can better improve the cell healing rate, more effectively repair the damaged barrier, and thus repair the skin.

[0188] In the compositions of Comparative Examples 9–13, the weight proportions of guaiac flexible bodies, soybean seed extract, nicotinamide, and camellia exosomes were not within the range of 0.1–1 part of guaiac flexible bodies, 0.1–5 parts of soybean seed extract, 0.1–5 parts of nicotinamide, and 0.01–3 parts of camellia exosomes. The cell healing rate was lower than that of Example 1. This indicates that the appropriate weight proportions of guaiac flexible bodies, soybean seed extract, nicotinamide, and camellia exosomes can better improve the cell healing rate and effectively repair the damaged cell barrier.

[0189] Test Example 2, experiment of the composition in reducing the over-activation of neurons and inhibiting inflammation under stress

[0190] The stress factor cortisol induces increased neurosensory transmission in keratinocytes, marked by an increase in calcitonin gene-related peptide (CGRP) and substance P. Therefore, after sample treatment, the lower the levels of CGRP and substance P, the lower the neuronal activity of cells under stress, and the stronger the ability of the composition to resist stress-induced emotional damage.

[0191] Test substance preparation: Dilute the composition (Examples 1-16, Comparative Examples 1-16) to 0.05% using DMEM cell culture medium, and record it as the sample solution; refrigerate.

[0192] The cell line used in this invention is human keratinocyte HaCaT (provided by Guangzhou Customs Testing Center). The testing conditions were: incubator temperature 37±1℃, saturated humidity, and carbon dioxide 5±1%. Cells were cultured and treated according to groupings, followed by testing for calcitonin gene-related peptide (CGRP) content and substance P content. The testing methods are as follows:

[0193] (1) Inoculate the cell suspension into culture flasks at a density of 1×10⁶ cells / year. 6 Cells / mL, cultured in DMEM high glucose medium (Gibco) containing 10% fetal bovine serum for 24 hours;

[0194] (2) The control group and the sample group were treated with 200 μL of PBS buffer containing 200 ng / mL cortisol for 30 minutes, and then the PBS buffer containing cortisol was discarded and the sample group was washed with PBS 3 times.

[0195] (3) The control group was given DMEM high glucose culture medium containing 10% fetal bovine serum, and the sample groups were given DMEM high glucose culture medium containing 0.05% of the composition prepared in the example or comparative example (diluted with PBS) and 10% fetal bovine serum, respectively. After culturing for 24 hours, the cells were collected.

[0196] (4) Determination of CGRP and substance P content: CGRP content was detected using the calcitonin gene-related peptide (CGRP) ELISA kit (Feien Biotech, catalog number EH1076) and substance P ELISA kit (Elabscience, catalog number E-EL-0067).

[0197] The ability of the composition to combat stress-induced mood impairment was represented by the reduction in the levels of calcitonin gene-related peptide (CGRP) and substance P.

[0198] CGRP inhibition rate (%) = (1 - CGRP sample group / CGRP control group) × 100%;

[0199] Inhibition rate of substance P (%) = (1 - substance P sample group / substance P control group) × 100%.

[0200] The results are shown in Table 4:

[0201] Table 4

[0202]

[0203]

[0204] As shown in Table 4, the compositions prepared using Examples 1-16 for improving the condition of stressed skin have a strong ability to resist stress-induced emotional damage, with CGRP inhibition rates of 37.3-73.9% and substance P inhibition rates of 42.5-62.7%, which can reduce neuronal overactivation and inhibit inflammation.

[0205] The compositions in Examples 1-5 used different weight parts of guaiac flexible body 1, soybean seed extract, nicotinamide, and camellia exosomes. The composition of Example 1 showed better inhibitory effects on CGRP and substance P than Examples 4-5, and Examples 4-5 were better than Examples 2-3. This indicates that the preferred weight parts of guaiac flexible body are 0.3-0.8 parts, the preferred weight parts of soybean seed extract are 0.3-3 parts, the preferred weight parts of nicotinamide are 0.5-3 parts, and the preferred weight parts of camellia exosomes are 0.1-2 parts. The prepared compositions have stronger anti-stress emotional damage capabilities and better effects in reducing neuronal overactivation and inhibiting inflammation.

[0206] Examples 1 and 6-16 used different guaiac flexible materials. Examples 1, 6-9 and 15-16 had different component weight parts. Examples 15-16 used excess caprylic / capric triglyceride and sorbitan palmitate-40. The CGRP inhibition rate and substance P inhibition rate of the compositions of Examples 1 and 8-9 were lower than those of Examples 6-7 and Examples 15-16. This shows that the appropriate weight ratio of guaiac, solubilizing carrier, emulsifier and stabilizer can better improve the composition's ability to resist stress-induced emotional damage.

[0207] Examples 1, 10, and 11 used different solubilizing carriers. Example 1 used caprylic / capric triglyceride as a solubilizing carrier, while Examples 10 and 11 used isopropyl myristate and ethylhexyl palmitate as solubilizing carriers, respectively. The composition of Example 1 showed better inhibition of CGRP and substance P under cortisol pressure than Examples 10 and 11, indicating that using caprylic / capric triglyceride as a solubilizing carrier can better improve the composition's ability to resist stress-induced emotional damage.

[0208] Examples 1 and 12 used different emulsifiers. Example 1 used polyglycerol-10 oleate and polyglycerol-6 laurate as emulsifiers, while Example 12 used hydrogenated lecithin. The composition of Example 1 showed better inhibition rates of CGRP and substance P than that of Example 12, indicating that using polyglycerol-10 oleate and polyglycerol-6 laurate as emulsifiers can better improve the composition's ability to resist stress-induced emotional damage. Using hydrogenated lecithin as an emulsifier in this system may lead to oil phase precipitation, decreased viscosity, and deactivation of active ingredients, thus weakening the composition's ability to resist stress-induced emotional damage.

[0209] Examples 1 and 13-14 used different types of sorbitan palmitate. Example 1 used sorbitan palmitate-40 as a stabilizer, while Examples 13 and 14 used sorbitan palmitate-80 and sorbitan palmitate-20 as stabilizers, respectively. Sorbitan palmitate-40 and sorbitan palmitate-80 have longer hydrophobic carbon chains, which can bring steric stability, crystallization inhibition ability and interfacial film strength. Therefore, Examples 1 and 13 have better ability to resist stress-induced emotional damage.

[0210] The composition of Comparative Example 1 uses guaiac, which has poor water solubility, is photosensitive and prone to discoloration, and has low skin penetration, resulting in a poor ability of the composition to resist stress-induced emotional damage.

[0211] The compositions of Comparative Examples 2–8 lacked at least one or two of the following: guaiac soft tissue, edamame seed extract, nicotinamide, and camellia exosomes. Comparative Examples 14–16 used other substances to replace edamame seed extract, nicotinamide, and camellia exosomes. The compositions prepared by these examples had lower CGRP inhibition rates and substance P inhibition rates, indicating that compositions with specific components can better improve the ability to resist stress-induced emotional damage.

[0212] In the compositions of Comparative Examples 9–13, the weight proportions of guaiac flexible bodies, soybean seed extract, nicotinamide, and camellia exosomes were not within the range of 0.1–1 part guaiac flexible bodies, 0.1–5 parts soybean seed extract, 0.1–5 parts nicotinamide, and 0.01–3 parts camellia exosomes. The CGRP inhibition rate and substance P inhibition rate of the compositions were lower than those of Example 1. This indicates that the appropriate weight proportions of guaiac flexible bodies, soybean seed extract, nicotinamide, and camellia exosomes can better improve the composition's ability to resist stress-induced emotional damage and have better effects in reducing neuronal overactivation and inhibiting inflammation.

[0213] Test Example 3, effect of the composition on the skin state of volunteers under stress

[0214] One hundred and five volunteers who were under chronic stress were recruited. Their stress levels were measured using the Perceived Stress Scale (CPSS-14) translated by Professor Yang Yanzhong. Those with a total score of 44 or higher were selected for this test. Volunteers were randomly divided into 35 groups of three. Under normal circumstances, volunteers continuously used the product on their entire face for 14 days. Each morning and evening, after cleansing and moisturizing, volunteers applied an appropriate amount of face cream (Application Examples 1-18, Control Examples 1-16, and Blank Example) to their face and massaged it in until absorbed. The product was used on the entire face twice a day, morning and evening. Follow-up visits were conducted after 14 days.

[0215] On the day of their visit, volunteers washed their faces with water without applying any products and sat quietly for 20 minutes in an air-conditioned room with a temperature of 21±1℃ and humidity of 50±10%. Facial skin improvement was assessed using instruments including acne count (calculating the total number of blackheads and papules, assessed using VISIA and by a doctor), Tewameter™ Hex test for transepidermal water loss (TEWL), Colorimeter CL 400 measurement of facial skin color (ITA° value), and VISIA test for red area area. Additionally, 3 mL of saliva was collected from volunteers at the beginning and 14 days later to detect the level of the stress hormone cortisol using a cortisol detection kit (Beyotime, catalog number PC169).

[0216] Improvement rate before and after use = |mean before use - mean after use| / mean before use × 100%;

[0217] The calculation results are shown in Table 5. The improvement rate presented in Table 5 is the improvement rate at the follow-up visit on day 14.

[0218] Table 5

[0219]

[0220]

[0221] The results are shown in Table 5: The compositions prepared in Examples 1-18 for improving skin condition caused by stress showed TEWL improvement rates of 4.7-22.3%, skin color improvement rates of 14.9-32.5%, redness area improvement rates of 10.3-27.9%, and cortisol improvement rates of 9.4-17.2%, indicating that they can improve skin condition problems caused by the stress hormone cortisol. The facial improvement in the subjects is shown in Table 5. Figure 3 As shown.

[0222] The compositions in Examples 1-5 used different weight parts of guaiac soft tissue 1, edamame seed extract, niacinamide, and camellia exosomes. The TEWL improvement rate, skin tone improvement rate, red area area improvement rate, and cortisol improvement rate of the composition in Example 1 were better than those in Examples 4-5, and Examples 4-5 were better than Examples 2-3. This indicates that the preferred weight parts of guaiac soft tissue 1 are 0.3-0.8 parts, the preferred weight parts of edamame seed extract are 0.3-3 parts, the preferred weight parts of niacinamide are 0.5-3 parts, and the preferred weight parts of camellia exosomes are 0.1-2 parts. The prepared compositions can better improve skin condition problems caused by the stress hormone cortisol.

[0223] Examples 1 and 6-16 used different guaiac flexible bodies. Examples 1, 6-9 and 15-16 had different component weight parts. Examples 15-16 used excess caprylic / capric triglyceride and sorbitan palmitate-40. The TEWL improvement rate, skin color improvement rate, red area area improvement rate and cortisol improvement rate of the compositions of Examples 1 and 8-9 were higher than those of Examples 6-7 and Examples 15-16. This shows that the appropriate weight ratio of guaiac, solubilizing carrier, emulsifier and stabilizer can better improve skin condition problems caused by the stress hormone cortisol.

[0224] Examples 1, 10, and 11 used different solubilizing carriers. Example 1 used caprylic / capric triglyceride as a solubilizing carrier, while Examples 10 and 11 used isopropyl myristate and ethylhexyl palmitate as solubilizing carriers, respectively. The composition of Example 1 showed higher TEWL improvement rate, skin tone improvement rate, red area improvement rate, and cortisol improvement rate than Examples 10 and 11, indicating that using caprylic / capric triglyceride as a solubilizing carrier can better improve skin condition problems caused by the stress hormone cortisol.

[0225] Examples 1 and 12 used different emulsifiers. Example 1 used polyglycerol-10 oleate and polyglycerol-6 laurate as emulsifiers, while Example 12 used hydrogenated lecithin as an emulsifier. The composition of Example 1 showed higher TEWL improvement rate, skin tone improvement rate, redness area improvement rate, and cortisol improvement rate than that of Example 12, indicating that using polyglycerol-10 oleate and polyglycerol-6 laurate as emulsifiers can better improve the skin condition caused by the stress hormone cortisol. Using hydrogenated lecithin as an emulsifier in this system may lead to oil phase precipitation, decreased viscosity, and inactivation of active ingredients, thus weakening its ability to improve skin conditions caused by the stress hormone cortisol.

[0226] Examples 1 and 13-14 used different types of sorbitan palmitate. Example 1 used sorbitan palmitate-40 as a stabilizer, while Examples 13 and 14 used sorbitan palmitate-80 and sorbitan palmitate-20 as stabilizers, respectively. Sorbitan palmitate-40 and sorbitan palmitate-80 have longer hydrophobic carbon chains, which can bring steric stability, crystallization inhibition ability and interfacial film strength. Therefore, Examples 1 and 13 can better improve skin condition problems caused by the stress hormone cortisol.

[0227] The composition of Comparative Example 1 uses guaiac, which has poor water solubility, photosensitivity and easy discoloration, and low skin penetration, resulting in the composition not being able to effectively improve the skin condition caused by the stress hormone cortisol.

[0228] The compositions of Comparative Examples 2–8 lacked at least one or two of the following: guaiac soft tissue, edamame seed extract, niacinamide, and camellia exosomes. Comparative Examples 14–16 used other substances to replace edamame seed extract, niacinamide, and camellia exosomes. The compositions prepared by these examples showed lower TEWL improvement rates, skin tone improvement rates, red area area improvement rates, and cortisol improvement rates, indicating that compositions with specific components can more effectively improve skin condition problems caused by the stress hormone cortisol.

[0229] In the compositions of Comparative Examples 9–13, the weight proportions of guaiac fibroblasts, edamame seed extract, niacinamide, and camellia exosomes were not within the range of 0.1–1 part guaiac fibroblasts, 0.1–5 parts edamame seed extract, 0.1–5 parts niacinamide, and 0.01–3 parts camellia exosomes. The TEWL improvement rate, skin tone improvement rate, red area area improvement rate, and cortisol improvement rate of the compositions were lower than those of Example 1. This indicates that appropriate weight proportions of guaiac fibroblasts, edamame seed extract, niacinamide, and camellia exosomes can more effectively improve skin conditions caused by the stress hormone cortisol.

[0230] This application utilizes the combined effects of guaiac soft tissue, edamame seed extract, niacinamide, and camellia exosomes to create a composition that improves the condition of stressed skin. Guaiac soft tissue and edamame seed extract can jointly inhibit the TRPV1 / P pathway to relieve neurogenic burning pain. Niacinamide and camellia exosomes can block α-MSH-mediated pigmentation and repair the skin barrier to reduce TEWL. At the same time, the four components can also activate collagen regeneration and resist external stimuli, achieving simultaneous blocking of the HPA axis cascade damage through four pathways: "nerve calming - melanin reduction - barrier repair - anti-aging," thus preventing the symptoms from recurring and worsening.

[0231] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of this application and are not intended to limit the scope of protection of this application. Although this application has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solutions of this application without departing from the substance and scope of the technical solutions of this application.

Claims

1. A composition for improving the condition of stressed skin, characterized in that, The composition comprises the following components in parts by weight: Guaiac soft tissue 0.1–1 part, soybean seed extract 0.1–5 parts, nicotinamide 0.1–5 parts, and camellia exosomes 0.01–3 parts; The guaiac flexible body comprises two phases with the following mass percentages: an oil phase of 15-35% and an aqueous phase of 65-85%; The oil phase includes guaiac, solubilizing carrier, emulsifier and stabilizer; The aqueous phase includes polyols and deionized water; The mass percentage of guaiazoline in the guaiazoline flexible body is not less than 2%.

2. The composition according to claim 1, characterized in that, The composition comprises the following components in parts by weight: Guaiac soft tissue 0.3–0.8 parts, soybean seed extract 0.3–3 parts, nicotinamide 0.5–3 parts, and camellia exosomes 0.1–2 parts.

3. The composition according to claim 1, characterized in that, The emulsifiers include polyglycerol-10 oleate and polyglycerol-6 laurate; the stabilizers include sorbitan palmitate; the solubilizing carriers include caprylic / capric triglyceride or isopropyl myristate; and the polyols include glycerol.

4. The composition according to claim 1, characterized in that, The weight ratio of guaiac, solubilizing carrier, emulsifier, and stabilizer is guaiac: solubilizing carrier: emulsifier: stabilizer = (1-5): (5-15): (8-20): (1-5); And / or, the weight ratio of the polyol to deionized water is polyol to deionized water = (10-30): (30-75).

5. The composition according to claim 4, characterized in that, The weight ratio of guaiac, solubilizing carrier, emulsifier, and stabilizer is guaiac: solubilizing carrier: emulsifier: stabilizer = (1.5-2): (7.5-10): (12-17): (3-4); And / or, the weight ratio of the polyol to deionized water is polyol to deionized water = (15-20):(47-61).

6. The composition according to claim 1, characterized in that, The method for preparing the guaiac flexible body includes the following steps: S1. Guaifenesin and solubilizing carrier are mixed evenly, then mixed with emulsifier and stabilizer and heated to dissolve to obtain oil phase; polyol and deionized water are mixed and heated to obtain aqueous phase; S2. Pour the oil phase into the aqueous phase, shear and homogenize to form a primary emulsion, and then homogenize the primary emulsion under high pressure to obtain a guaiac flexible body.

7. The composition according to claim 6, characterized in that, In step S1, guaiac and solubilizing carrier are mixed evenly, and then mixed with emulsifier and stabilizer and heated to 70-75°C to dissolve and obtain oil phase; polyol and deionized water are mixed and heated to 80-85°C to obtain aqueous phase.

8. The composition according to claim 6, characterized in that, In step S2, the rotation speed for shearing homogenization is 5000-8000 rpm, and the time is 1-5 min. And / or, the pressure for high-pressure homogenization is 600–1200 bar, the rotation speed is 8000–15000 rpm, and the number of homogenization cycles is 3–5.

9. The use of the composition according to any one of claims 1 to 8 in the preparation of cosmetics for the care of stressed skin.

10. A cosmetic product for stress-induced skin care, characterized in that, The cosmetics include face cream; The face cream comprises the following components by weight percentage: The composition as described in any one of claims 1 to 8 comprises 1% to 5% thickener, 0.1% to 2% humectant, 0.5% to 5% emulsifier, 1% to 10% pH adjuster, 0.01% to 0.3% preservative, and the balance being deionized water.

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