Anti-pigmentation composition for improving elasticity of vulva tissue and preparation method of anti-pigmentation composition

Abstract

The invention relates to an anti-pigmentation composition for improving vulva tissue elasticity and a preparation method thereof, and belongs to the technical field of external care products. The composition comprises the following components in percentage by mass: 0.5-8% of a whitening and brightening component which is selected from at least one of nicotinamide, arbutin, dipotassium glycyrrhizinate, a licorice extract and a safflower extract; 0.5-5% of an elastic repair component, which is selected from at least one of elastin, hydrolyzed red algae extract, saccharide isomeride, glycosylglycerol 50 and sclerotium gum; 0.5-10% of a soothing and flora adjusting component, which is selected from at least one of an oldenlandia diffusa extract, a purslane extract, a sophora flavescens root extract, a chrysanthellum indicum extract, an aloe barbadensis extract, an althaea officinalis extract and a salvia miltiorrhiza root extract; and the balance of solvent and cosmeceutically acceptable auxiliary materials. The traditional Chinese medicine composition has the characteristics of improving vulva skin elasticity and fading pigmentation.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of external care products, and more particularly relates to an anti-pigmentation composition for improving the elasticity of vulvar tissue and a preparation method thereof. BACKGROUND

[0002] The physiological structure of the skin on the female external genital area is special and significantly different from that of the skin on the face, hands and other conventional parts. The stratum corneum of the skin on the external genital area is thinner than that of the skin on the face and is rich in sweat glands and sebaceous glands, making it more sensitive and fragile. In daily life, the skin on the external genital area inevitably undergoes continuous physical friction with underpants, sanitary napkins and the skin on the inner side of the thighs. This long-term mechanical stimulation can cause a series of skin problems: first, physical abrasion, which makes the stratum corneum thin and impairs the barrier function; second, repeated friction stimulation can induce an inflammatory response and activate melanocytes, leading to excessive production and deposition of melanin, resulting in darkening of the local skin color and blackening, which seriously affects the appearance and causes psychological distress to women; in addition, long-term friction and inflammatory state can also damage the collagen and elastic fiber structure of the skin, leading to skin laxity and lack of elasticity, showing signs of aging.

[0003] At the same time, as a sentinel of the vagina, the microecological environment of the external genital area is closely connected with the inside of the vagina. Vaginal secretions (such as leukorrhea) continuously contact the skin on the external genital area, and these secretions contain exfoliated cells, lactobacilli and a small amount of other microorganisms. When the skin barrier function of the external genital area is impaired or not properly cleaned, pathogenic bacteria (such as Staphylococcus aureus and Escherichia coli) from the outside world are easy to colonize and proliferate on the external genital area. These harmful microorganisms not only cause itching, odor and other problems on the external genital area, but also can cause upper infection, destroy the balance of the dominant flora in the vagina dominated by lactobacilli, induce bacterial vaginosis and other gynecological inflammation, and even indirectly affect the stability of the endocrine system of the body.

[0004] Currently, there are great risks and no obviousness in directly applying the conventional facial or body skincare concept to external genital care. For example, fruit acids, salicylic acid, high-concentration vitamin C or A alcohol ingredients commonly used for facial whitening are contraindicated for the extremely sensitive skin on the external genital area, as they can cause severe burning, stinging and allergic reactions. Similarly, although many broad-spectrum antibacterial agents can effectively kill bacteria on the hands or general skin surface, if used on the external genital area, they will indiscriminately kill all microorganisms including beneficial lactobacilli, thereby destroying the natural acidic protective barrier and creating conditions for the growth of harmful bacteria. Therefore, the prior art lacks a multi-effect-in-one care product that can simultaneously solve the problems of pigmentation and decreased elasticity of the skin on the external genital area and maintain and improve its microecological environment. SUMMARY

[0005] The present application aims to provide an anti-pigmentation composition for improving the elasticity of vulvar tissue and a preparation method thereof, which has the characteristics of maintaining the vaginal microecological environment while improving the elasticity of vulvar skin and lightening pigmentation.

[0006] The object of the present application can be achieved by the following technical solutions: An anti-pigmentation composition for improving the elasticity of vulvar tissue, comprising the following components in mass percentage: A whitening component: 0.5-8%, selected from at least one of niacinamide, arbutin, dipotassium glycyrrhizinate, licorice extract, and safflower extract; An elasticity repair component: 0.5-5%, selected from at least one of elastin, hydrolyzed red algae extract, sugar isomer, glycerol glucoside 50, and small core bacterial glue; A soothing and flora regulating component: 0.5-10%, selected from at least one of balanophora manillana extract, spilanthes acmella extract, sophora flavescens root extract, golden chamomile extract, aloe vera barbadensis miller extract, malva sylvestris extract, and salvia miltiorrhiza root extract; A solvent and cosmetically acceptable adjuvant: the balance.

[0007] Further, the cosmetically acceptable adjuvant comprises the following components in mass percentage: A penetration promoting component: 0.05-1%, selected from tetrahydro-piperine; A moisturizing component: 3-10%, selected from at least one of butanediol, sodium hyaluronate, glycerol, 1,3-propanediol, and trehalose; An oil phase component: 0-25%, selected from at least one of squalane, camellia seed oil, shea butter, evening primrose oil, hydrogenated polyisobutylene, dimethicone, pentaerythrityl tetraisostearate, and isononyl isononanoate; An emulsifying thickening agent: 0.1-8%, selected from at least one of carbomer, cetylstearyl alcohol, cetylstearyl glucoside 20, glyceryl stearate 65, and PEG-100 stearate 35; A pH regulator: for adjusting the pH of the system to 4.0-5.5; The solvent is deionized water: the balance.

[0008] Further, the cosmetically acceptable adjuvant further comprises at least one of a preservative, an antioxidant, a chelating agent, and a fragrance.

[0009] As a preferred technical solution of the present application, the whitening component is a combination of niacinamide, arbutin, and dipotassium glycyrrhizinate.

[0010] Among them, nicotinamide can inhibit the transport of melanin to keratinocytes and accelerate the metabolism of the stratum corneum; arbutin can inhibit tyrosinase activity from the source and reduce melanin production; potassium glycyrrhizinate can not only inhibit tyrosinase but also has excellent anti-inflammatory effect, and its strong anti-inflammatory effect can block the post-inflammatory pigmentation caused by friction from the source. The combination of the three can realize efficient whitening under the premise of ensuring the safety of private skin through multi-pathway synergistic effect.

[0011] Further, the mass percentage of the whitening component is 0.5-1%, 0.5-1%, 0.5-2%, 0.5-3%, 0.5-4%, 0.5-5%, 0.5-6% or 0.5-7%.

[0012] As a preferred technical solution of the present application, the elastic repair component is a combination of elastin and saccharide isomerate.

[0013] Among them, elastin can directly supplement the lost elastic components of the skin and increase the skin resilience; saccharide isomerate is a moisturizer similar in structure to the stratum corneum of human skin, which can combine with keratin like a magnet, providing up to 72 hours of deep moisturizing effect and strengthening the skin barrier.

[0014] Further, the mass percentage of the elastic repair component is 0.5-1%, 0.5-1%, 0.5-2%, 0.5-3% or 0.5-4%.

[0015] As a preferred technical solution of the present application, the soothing and flora regulating component is a combination of extract of Sarcandra glabra, extract of spilanthes and extract of Sophora flavescens.

[0016] Sarcandra glabra has the effects of clearing heat and resolving toxicity and anti-inflammatory; the extract of spilanthes is rich in polysaccharides and flavonoids, which can effectively soothe skin irritation and anti-allergy; the ingredients such as sophoramine in the extract of Sophora flavescens have broad-spectrum antibacterial effect. Unlike broad-spectrum antibacterial agents that can destroy the microecology, this combination can specifically inhibit the growth of harmful bacteria such as Staphylococcus aureus and Escherichia coli, but has little effect on lactobacillus which is essential to maintain the weak acid environment. This intelligent ability to regulate flora balance solves the contradiction between safety and efficacy that has long plagued the field of private care.

[0017] Further, the mass percentage of the soothing and flora regulating component is 0.5-1%, 0.5-1%, 0.5-2%, 0.5-3%, 0.5-4%, 0.5-5%, 0.5-6%, 0.5-7%, 0.5-8% or 0.5-9%.

[0018] Further, the pH regulator is arginine or citric acid.

[0019] The pH regulator is mainly used to adjust the pH value of the system close to the physiological pH of the vulva skin to avoid affecting the balance of the bacterial flora.

[0020] The preservative is at least one of chlorphenesin, p-hydroxyacetophenone, caprylhydroxamic acid, ethylhexylglycerin, 1,2-hexanediol; the antioxidant is tocopherol or tocopherol acetate.

[0021] Further, the dosage form of the composition is a gel, an emulsion or a cream.

[0022] As a preferred technical solution of the present application, the composition is in the form of a gel; the mass percentage of the oil phase component is 0-2%, and the emulsifying thickening agent is carbomer.

[0023] The dosage form has a refreshing skin feel, is easy to absorb, and is suitable for use in summer.

[0024] In another preferred technical solution, the composition is in the form of an emulsion; the mass percentage of the oil phase component is 2-10%, and the emulsifying thickening agent is at least one of cetylstearyl alcohol, cetylstearyl glucoside 20, glyceryl stearate 65, and PEG-100 stearate 35.

[0025] The dosage form has a relatively refreshing skin feel and can form a protective oil film on the skin surface, having both certain moisturizing degree and high comfort.

[0026] In another preferred technical solution, the composition is in the form of a cream; the mass percentage of the oil phase component is 10-25%, and the emulsifying thickening agent is at least one of cetylstearyl alcohol, glyceryl stearate 65, and PEG-100 stearate 35.

[0027] The dosage form has high moisturizing degree and can form a protective oil film on the skin surface, being suitable for use in dry skin or in autumn and winter.

[0028] The preparation method of the gel dosage form composition as described above comprises the following steps: S1, mixing the moisturizing component and deionized water, and then adding the emulsifying thickening agent to swell sufficiently to obtain a gel body; S2, adding the elasticity repair component, the whitening component, and the soothing and bacterial flora regulating component, heating to 40-45℃, and stirring to dissolve; S3, after the gel is cooled to 36-42℃, adding the pH regulator to adjust the pH of the system to 4.0-5.5, and then adding the penetration promoting component and the remaining excipients after the gel is cooled to 35-40℃, and stirring to obtain the gel dosage form composition.

[0029] The preparation method of the emulsion or cream dosage form composition as described above comprises the following steps: S1, mix the moisturizing component and deionized water, heat to 75-85℃, keep warm and stir to obtain the water phase; mix the oil phase component and emulsifying thickening agent, heat to 75-85℃, keep warm and stir to obtain the oil phase; S2, continuously add the oil phase into the water phase or continuously add the water phase into the oil phase with stirring to obtain an emulsion; S3, after the emulsion is cooled to 40-50℃, add the elastic repair component, whitening component and soothing and flora regulating component, and stir to mix; S4, after the emulsion is cooled to 35-40℃, add the pH regulator to adjust the pH of the system to 4.0-5.5, then add the penetration promoting component and the remaining excipients, and stir to obtain the emulsion type composition.

[0030] Further, in step S2, when the composition is an emulsion, the oil phase is continuously added into the water phase; when the composition is a cream, the water phase is continuously added into the oil phase.

[0031] The beneficial effects of the present application are: (1) The composition of the present application abandons the irritating ingredients which are effective for facial skin but harmful for the private parts, and the pH value is adjusted to be close to the weak acidic environment (4.0-5.5) of the female external genitalia, which is skin-friendly and does not destroy the physiological balance; through the scientific compounding of mild raw materials, the elasticity of the external genital skin can be effectively improved, the pigment deposition can be lightened, the skin barrier can be enhanced, and a healthy microecological environment can be maintained, while the composition has the characteristics of mildness, non-irritation and easy absorption; by introducing the penetration promoting agent tetrahydro-piperine, the skin absorption channel can be effectively opened, so that the macromolecules or active ingredients with strong polarity such as niacinamide and elastin can penetrate into the deep layer of the skin better, thereby improving the health and appearance of the female private parts, and having the beneficial effects of specifically inhibiting harmful bacteria (such as Staphylococcus aureus) and protecting beneficial lactobacilli.

[0032] (2) The barrier repair component of the present application provides a healthy "soil" for the soothing and flora regulating component, so that it can play a better role; and the soothing and flora regulating component can block the post-inflammatory pigment deposition pathway that the whitening component needs to deal with. This chain-like synergistic effect of "repairing the barrier → optimizing the flora → reducing inflammation → lightening the pigment" makes the overall effect far exceed the expectation of single functional ingredient. The present application not only improves the appearance (whitening and tightening), but also forms a protective film to reduce friction and regulate the balance of flora, thereby alleviating the unique physiological discomfort of the part, maintaining the health of the private parts from the biological level, and bringing unexpected technical effects.

[0033] (3) The preparation process of the present application is simple and easy to industrialize. The composition is mild and non-irritating, suitable for daily external genital care, and solves the problem of single function and strong irritation of existing products. DETAILED DESCRIPTION

[0034] To further clarify the technical means and effects taken by the present application to achieve the predetermined inventive purpose, the specific embodiments, structures, features and effects thereof according to the present application are described in detail below in combination with the embodiments.

[0035] Example 1 The present example provides an anti-pigmentation composition for improving the elasticity of vulvar tissue, specifically, the composition is in a gel dosage form, the composition comprises the following components by mass percentage: The preparation method of the above composition comprises the following steps: S1, mix the solvent and the moisturizing component, then slowly disperse the thickening agent in the mixed solution of the solvent and the moisturizing component, and stir until completely swelled and transparent; S2, add the elasticity repair component, the whitening component and the soothing and flora regulating component, heat to 42±2℃, and stir until completely dissolved; S3, cool to 38±2℃, add the arginine aqueous solution, adjust the pH of the system to 4.5±0.5, and when the system cools below 40℃, sequentially add the penetration enhancer, the preservative and the antioxidant, stir uniformly, then stand for defoaming, and the finished product is obtained.

[0036] Example 2 The present example provides an anti-pigmentation composition for improving the elasticity of vulvar tissue, specifically, the composition is in a gel dosage form, the composition comprises the following components by mass percentage: The preparation method of the above composition comprises the following steps: S1, mix the solvent and the moisturizing component, heat to 80℃, and stir uniformly to obtain the water phase; mix the oil phase component and the emulsifier, heat to 80℃, and stir until completely dissolved and clear to obtain the oil phase; S2, continuously and slowly add the oil phase into the water phase with stirring operation, homogenize for 2-3 minutes to obtain a uniform emulsion; S3, with stirring operation, when the emulsion cools to 45℃, add the elasticity repair component, the whitening component and the soothing and flora regulating component, and stir uniformly; S4, add the arginine aqueous solution, adjust the pH of the system to 4.5±0.5, and when the system cools below 40℃, sequentially add the penetration enhancer, the preservative, the antioxidant and the fragrance, stir uniformly, then stand for defoaming, and the finished product is obtained.

[0037] Example 3 The present embodiment provides an anti-pigmentation composition for improving the elasticity of vulvar tissue, in particular, the composition is in the form of a cream, and the composition comprises the following components by mass percentage: The preparation method of the above composition comprises the following steps: S1, mix the solvent and the moisturizing component, heat to 80℃, stir uniformly to obtain the water phase; mix the oil phase component and the emulsifier, heat to 80℃, stir until completely dissolved and clear to obtain the oil phase; S2, continuously and slowly add the water phase into the oil phase with stirring operation, homogenize for 3-5 minutes to obtain a uniform cream; S3, with stirring operation, when the cream cools to 45℃, add the elasticity repair component, the whitening component and the soothing and flora regulating component, and stir uniformly; S4, add the arginine aqueous solution to adjust the pH of the system to 4.5±0.5, and then add the penetration enhancer, the preservative, the antioxidant and the fragrance in sequence when the system cools to below 40℃, stir uniformly, and then stand still to remove bubbles to obtain the finished product.

[0038] Comparative Example 1 Compared with Example 1, the difference between Comparative Example 1 and Example 1 is that the sugar epimer in Example 1 is replaced by an equal amount of retinol with a concentration of 0.2%, and the other components, preparation steps and parameters are the same.

[0039] Comparative Example 2 Compared with Example 2, the difference between Comparative Example 2 and Example 2 is that the arbutin and dipotassium glycyrrhizinate in Example 2 are replaced by an equal amount of sodium ascorbyl phosphate with a concentration of 2%, and the other components, preparation steps and parameters are the same.

[0040] Comparative Example 3 Compared with Example 3, the difference between Comparative Example 3 and Example 3 is that the Sophora flavescens extract in Example 3 is replaced by an equal amount of cucumber extract, and the other components, preparation steps and parameters are the same.

[0041] Comparative Example 4 Compared with Example 1, the difference between Comparative Example 4 and Example 1 is that the elasticity repair component, the whitening component and the soothing and flora regulating component are not added in Comparative Example 4, and the weights of the three components are made up by water, and the other components, preparation steps and parameters are the same.

[0042] In order to verify the beneficial effects of the composition of the present application and the necessity of the compounding of each component thereof, 70 healthy female volunteers aged 25-45 years old who complained of dull and slack skin on the vulva were selected for testing. They were randomly divided into seven groups, 10 people in each group, including: Group A: using the gel product of Example 1.

[0043] Group B: Emulsion product of Example 2 was used.

[0044] Group C: Cream product of Example 3 was used.

[0045] Group D: Gel product of Comparative Example 1 was used.

[0046] Group E: Emulsion product of Comparative Example 2 was used.

[0047] Group F: Cream product of Comparative Example 3 was used.

[0048] Group G (control group): Gel product of Comparative Example 4 was used (basic moisturizing gel without any active ingredients).

[0049] The volunteers applied an appropriate amount of the product to the vulvar skin area and the unilateral facial area once a day in the morning and evening, respectively, and continuously used for 8 weeks. The index detection was carried out at 0thweek, 4thweek and 8thweek, respectively.

[0050] (1) Skin pigment improvement test The brightness value (L* value) of the skin of the vulvar area of the subject was measured using a color difference meter (Konica Minolta CM-700d). The higher the L* value, the lighter the skin color.

[0051] The test results are shown in Table 1.

[0052] Table 1 From the test results in Table 1, it can be seen that after 8 weeks of use, the L* values of the vulvar and facial skin of the inventive Examples A, B and C groups were significantly improved, indicating that the composition can effectively lighten pigments and improve skin dullness, but the L* value of the vulvar skin is more significantly improved, indicating that the composition of the present application is particularly suitable for vulvar skin. In the comparative examples, groups D and F also showed good whitening effect because they retained the whitening components. However, group E had a greater impact on the vulvar skin because it lacked the key whitening components potassium glycyrrhizinate and arbutin, and the L* value of the vulvar skin had no significant difference from group G (control group), and the whitening effect was almost negligible. This fully proves that the whitening and lightening components in the present application have a significant effect in vulvar care, and their presence is necessary.

[0053] (2) Skin elasticity improvement test The total elasticity of the skin (R2 value, Ua / Uf) was measured using a skin elasticity tester (Cutometer®MPA580). The closer the R2 value to 1, the better the skin elasticity. The results are shown in Table 2.

[0054] Table 2 From the results of Table 2, it can be seen that the total elasticity R2 values of the vulvar skin of groups A, B and C are significantly improved after 8 weeks, indicating that the composition of the application can effectively improve the laxity of the vulvar skin and enhance the tightness and elasticity. Among them, the effect of group C (cream) and group B (emulsion) with more moisturizing and higher elastin content is particularly prominent. Although the total elasticity R2 values of the facial skin of groups A, B and C are improved after 8 weeks, the improvement effect is not obvious, indicating that the composition of the application is particularly suitable for vulvar skin. In the comparative examples, groups E and F also show good elasticity improvement effect due to the retention of the elasticity repair component. In contrast, the elasticity improvement effect of the vulvar skin of group D is not significantly different from that of group G (control group) due to the lack of key carbohydrate isomers. This proves that the elasticity repair component in the application plays a crucial role in restoring the elasticity of the vulvar skin and is indispensable.

[0055] (3) Test of skin flora regulation ability At weeks 0 and 8, the surface of the vulvar skin of the subjects was wiped with a sterile cotton swab for microbial culture. The number of colonies of Staphylococcus aureus (representative of harmful bacteria) and Staphylococcus epidermidis (representative of beneficial / neutral bacteria) was observed.

[0056] Result analysis: At week 8, the number of colonies of Staphylococcus aureus of groups A, B and C was reduced by about 40-55% compared with that at week 0, while the number of Staphylococcus epidermidis remained stable or increased slightly. In the comparative examples, groups D and E also showed inhibition of harmful bacteria due to the retention of effective soothing and flora regulation components. However, group F did not show significant inhibition effect due to the replacement of the soothing and flora regulation components with weaker cucumber extract, and the number of Staphylococcus aureus was not significantly different from that of group G (control group). This proves that the preferred soothing and flora regulation components of the application have clear advantages in selectively inhibiting harmful bacteria and regulating the microecology of the vulvar skin.

[0057] (4) Test of use satisfaction After 8 weeks of experience, the satisfaction of the volunteers with the product used was investigated, with 0 being the lowest score and 10 being the highest score. The results of the investigation showed that the product scores of groups A, B and C were 9 or above in terms of the experience effect (including irritation and comfort) of the vulvar use, while the scores of groups D, E, F and G were between 7 and 8, indicating that the product of the application has a good experience of application; while the product scores of groups A, B and C were between 6 and 7, and the scores of groups D, E, F and G were also between 6 and 7 in terms of the experience effect of facial use, and some volunteers feedback that there was a slight irritation in the initial stage of facial use, which may be due to the slight irritation of the pH value of the product to the facial skin.

[0058] Based on the above experimental results, the female vulva care composition disclosed in the present application, whether in the form of a gel, emulsion or cream, can effectively improve the problems of pigmentation and decreased elasticity of the vulvar skin, and has a positive effect on maintaining the local microecological health. The comparative experiment further confirms that the whitening and lightening component, the elasticity repairing component, and the soothing and flora regulating component in the present application are the core to achieve the corresponding effects, and it is proved that the composition of the present application is especially suitable for the care of the vulvar skin.

[0059] The above is only a preferred embodiment of the present application, and does not limit the present application in any form. Although the present application has been disclosed as above with a preferred embodiment, it is not intended to limit the present application. Any person skilled in the art can make some changes or modifications to the above disclosed technical content to obtain equivalent embodiments with equivalent changes, without departing from the technical solution of the present application. Any modification, equivalent change and modification of the above embodiments based on the technical essence of the present application are still within the scope of the technical solution of the present application.

Claims

1. A composition for improving the elasticity of vulvar tissue and resisting pigmentation deposition, characterized in that, By mass percentage, it includes the following components: Whitening and brightening ingredients: 0.5-8%, selected from at least one of niacinamide, arbutin, dipotassium glycyrrhizate, licorice extract, and safflower extract; Elastic repair component: 0.5-5%, selected from at least one of elastin, hydrolyzed red algae extract, saccharide isomers, glyceryl glucoside 50, and sclerotium gum; Soothing and gut microbiota regulating components: 0.5-10%, selected from at least one of the following: Hedyotis diffusa extract, Portulaca oleracea extract, Sophora flavescens root extract, Chamomile extract, Aloe vera extract, Marshmallow root extract, and Salvia miltiorrhiza root extract; and Solvents and excipients acceptable for cosmeceuticals: balance.

2. The anti-pigmentation composition for improving vulvar tissue elasticity according to claim 1, characterized in that, By weight percentage, the excipients acceptable for use in cosmeceuticals include the following components: Penetration-enhancing component: 0.05-1%, selected from tetrahydropiperine; Moisturizing ingredients: 3-10%, selected from at least one of butylene glycol, sodium hyaluronate, glycerin, 1,3-propanediol, and trehalose; Oil phase component: 0-25%, selected from at least one of squalane, camellia seed oil, shea butter, evening primrose oil, hydrogenated polyisobutylene, polydimethylsiloxane, pentaerythritol tetraisostearate, and isononyl isononanoate; Emulsifying thickener: 0.1-8%, selected from at least one of carbomer, cetearyl alcohol, cetearyl glucoside 20, glyceryl stearate 65, and PEG-100 stearate 35; pH adjuster: used to adjust the pH of the system to 4.0-5.5; The solvent is deionized water: balance.

3. The anti-pigmentation composition for improving vulvar tissue elasticity according to claim 1 or 2, characterized in that, The whitening and brightening ingredients are a combination of niacinamide, arbutin and dipotassium glycyrrhizate; The elastic repair component is a combination of elastin and carbohydrate isomers; The soothing and microbiome-regulating components are a combination of extracts from Hedyotis diffusa, Portulaca oleracea, and Sophora flavescens root.

4. The anti-pigmentation composition for improving vulvar tissue elasticity according to claim 2, characterized in that, The pH adjuster is arginine or citric acid.

5. The anti-pigmentation composition for improving vulvar tissue elasticity according to claim 2, characterized in that, The excipients acceptable for use in cosmeceuticals also include at least one of preservatives, antioxidants, chelating agents, and fragrances.

6. The anti-pigmentation composition for improving vulvar tissue elasticity according to claim 1, characterized in that, The composition is in the form of a gel, emulsion, or cream.

7. The anti-pigmentation composition for improving vulvar tissue elasticity according to claim 7, characterized in that, When the composition is a gel formulation, the oil phase component has a mass percentage of 0-2%, and the emulsifying thickener is carbomer; When the composition is an emulsion formulation, the oil phase component has a mass percentage of 2-10%, and the emulsifying thickener is at least one of cetearyl alcohol, cetearyl glucoside 20, glyceryl stearate 65, and PEG-100 stearate 35. When the composition is a cream formulation, the oil phase component has a mass percentage of 10-25%, and the emulsifying thickener is at least one of cetearyl alcohol, glyceryl stearate 65, and PEG-100 stearate 35.

8. A method for preparing an anti-pigmentation composition for improving vulvar tissue elasticity as described in any one of claims 2-7, characterized in that, The composition is a gel formulation, and the preparation method includes the following steps: S1. Mix the moisturizing components and deionized water, then add the emulsifying thickener and allow it to swell fully to obtain a gel. S2. Add elastic repair components, whitening and brightening components, and soothing and microbiome regulating components, heat to 40-45℃, and stir until dissolved; S3. After the gel cools to 36-42℃, add a pH adjuster to adjust the pH of the system to 4.0-5.

5. After the gel cools to 35-40℃, add the penetration enhancer and the remaining excipients, and stir to obtain the gel formulation composition.

9. A method for preparing an anti-pigmentation composition for improving vulvar tissue elasticity as described in any one of claims 2-7, characterized in that, The composition is an emulsion or cream formulation, and the preparation method includes the following steps: S1. Mix the moisturizing component and deionized water, heat to 75-85℃, and stir while maintaining the temperature to obtain the aqueous phase; mix the oil phase component and emulsifying thickener, heat to 75-85℃, and stir while maintaining the temperature to obtain the oil phase; S2. With stirring, the oil phase is continuously added to the aqueous phase or the aqueous phase is continuously added to the oil phase to obtain an emulsion. S3. Once the emulsion has cooled to 40-50℃, add the elasticity repair component, whitening and brightening component, and soothing and microbiome regulating component, and stir to mix. S4. After the emulsion cools to 35-40℃, add a pH adjuster to adjust the pH of the system to 4.0-5.5, then add the penetration enhancer and the remaining excipients, and stir to obtain an emulsion composition.

10. The preparation method according to claim 9, characterized in that, In step S2, when the composition is an emulsion, the oil phase is continuously added to the aqueous phase; when the composition is a cream, the aqueous phase is continuously added to the oil phase.

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