Prostate targeted puncture method and device based on combination of mpMRI and ultrasonic image, medium and program product
By using rotational ranging to locate the prostate, and combining mpMRI and ultrasound images, distances a and b and the included angle θ are measured, achieving precise positioning for targeted prostate puncture. This improves the diagnostic success rate and detection rate, and reduces the missed detection rate.
Patent Information
- Application Number
- CN202511444687.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-10-10
- Publication Date
- 2025-12-19
AI Technical Summary
In existing technologies, prostate targeted puncture methods are difficult to achieve precise localization, especially the mpMRI-TRUS cognitive fusion method, which lacks measurement data and leads to inaccurate localization.
The rotational ranging method is used to achieve precise targeted localization by measuring distances a and b and the included angle θ in mpMRI images and combining them with ultrasound images.
It improved the diagnostic success rate and targeted biopsy detection rate of prostate cancer and reduced the false negative rate, especially in the subgroup with larger prostate volume.
Smart Images
Figure CN121169906A_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The present application relates to the field of intelligent medical treatment, and more particularly, to a prostate targeted biopsy method, device, medium and program product based on mpMRI and ultrasound images. BACKGROUND
[0002] Prostate cancer is a common malignant tumor in men, with an incidence rate second only to lung cancer, becoming the second largest tumor threatening men's health. Prostate biopsy is the gold standard for diagnosing prostate cancer, mainly including systematic biopsy (SB) and targeted biopsy (TB). Transrectal ultrasound (TRUS) guided 12-needle systematic biopsy is the most commonly used prostate biopsy scheme in clinical practice, but it has the disadvantages of low detection rate, high randomness and underestimation of Gleason score.
[0003] In order to overcome the shortcomings of systematic biopsy, researchers began to combine mpMRI with TRUS, thereby forming prostate targeted biopsy technology. There are three main ways of prostate magnetic resonance guided targeted biopsy: direct magnetic resonance guided targeted biopsy, magnetic resonance and TRUS software fusion targeted biopsy, and mpMRI-TRUS cognitive fusion targeted biopsy. MpMRI-TRUS cognitive fusion is the most commonly used targeted biopsy method, but this method is difficult to accurately locate the target area due to the lack of measurement data and subjective cognition. SUMMARY
[0004] The present application aims to at least solve one of the technical problems existing in the prior art. To this end, the present application provides a prostate targeted biopsy method, device, medium and program product based on the combination of mpMRI and ultrasound images; the method of the present application can achieve accurate targeted positioning by measuring only three values according to the existing magnetic resonance and ultrasound images of the patient through the proposed rotation ranging positioning method.
[0005] The first aspect of the present application discloses a prostate targeted biopsy method based on the combination of mpMRI and ultrasound images, the method comprising:
[0006] S101, acquiring an mpMRI image containing a tumor to be punctured, the mpMRI image including a transverse image and a sagittal image;
[0007] S102, defining the median anteroposterior diameter as the y-axis based on the mpMRI image; defining the intersection of the y-axis and the anterior wall of the rectum as the intersection, defining the line passing through the intersection and perpendicular to the y-axis as the x-axis, and defining the line passing through the intersection and perpendicular to the y-axis as the z-axis;
[0008] S103, measuring a distance a between the intersection and the center of the tumor to be punctured according to the cross-sectional image;
[0009] S104, measuring a distance b between the lateral edge of the tumor and the edge of the prostate along the z-axis direction according to the sagittal image; the direction of the distance b is parallel to the z-axis;
[0010] S105, determining the target puncture area according to the distance a and the distance b.
[0011] In some embodiments, the method further comprises:
[0012] measuring an angle θ between the distance a and the y-axis;
[0013] acquiring an ultrasound image of a median sagittal section of the tumor to be punctured by using a rectal ultrasound probe, rotating the ultrasound probe by an angle θ to obtain a target ultrasound image π3, and locating the tumor to be punctured and the target puncture area in the target ultrasound image.
[0014] In some embodiments, the target ultrasound image is a cross-sectional image of the tumor to be punctured.
[0015] In some embodiments, the angle θ includes a positive value or a negative value.
[0016] In some embodiments, the method further comprises: performing puncture by using a biopsy needle according to the target ultrasound image to reach the target puncture area.
[0017] Optionally, the puncture distance is less than the distance b.
[0018] In some embodiments, the mpMRI image includes T2WI, DWI and DCE images.
[0019] In some embodiments, when the ultrasound probe enters the rectum, the center line of the ultrasound probe is parallel to the z-axis.
[0020] The second aspect of the present application discloses a computer device, which comprises a memory and a processor; the memory is used to store a computer program; and the processor executes the computer program to realize the steps of the above method.
[0021] The third aspect of the present application discloses a computer readable storage medium, which stores a computer program; and the computer program is executed by a processor to realize the steps of the above method.
[0022] The fourth aspect of the present application discloses a computer program product, which comprises a computer program; and the computer program is executed by a processor to realize the steps of the above method.
[0023] The present application has the following beneficial effects:
[0024] The application discloses a rotating distance measuring positioning method, which is characterized in that: according to the existing magnetic resonance and ultrasound images of a patient, a coordinate axis is established based on the existing magnetic resonance image, and three values of distance a / distance b / angle theta are measured, and then accurate target positioning can be realized based on the ultrasound image and the above values. BRIEF DESCRIPTION OF DRAWINGS
[0025] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed to be used in the embodiment description will be briefly introduced. Obviously, the drawings in the following description are only some embodiments of the present application, and other drawings can be obtained by those skilled in the art without creative effort on the basis of these drawings.
[0026] Figure 1 is a method flowchart provided by the first aspect of the embodiment of the present application;
[0027] Figure 2 is a schematic diagram of a targeted puncture system based on mpMRI and ultrasound images provided by the second aspect of the embodiment of the present application;
[0028] Figure 3 is a schematic diagram of a computer device provided by the embodiment of the present application;
[0029] Figure 4 is a schematic diagram of the architecture of an exemplary computing device provided by the embodiment of the present application;
[0030] Figure 5 is a schematic diagram of a storage medium provided by the embodiment of the present application;
[0031] Figure 6 is an image schematic diagram marked in the pi1 / pi2 / pi3 plane, wherein, Figure 6 A is the distance mark of pi1, i.e. the cross-sectional image, Figure 6 B is the distance mark of pi2, i.e. the sagittal image, Figure 6 C is the distance mark of pi3, i.e. the target ultrasound image;
[0032] Figure 7 is a schematic diagram of the relative position of the pi1 / pi2 / pi3 plane and the prostate provided by the embodiment of the present application. DETAILED DESCRIPTION
[0033] In order to better understand the technical scheme of the present application, the technical scheme in the embodiments of the present application will be clearly and completely described below in conjunction with the accompanying drawings of the embodiments of the present application.
[0034] In some of the processes described in this specification, including in the description and claims of the application and in the above-described drawings, numerous specific details are recited in order to provide a thorough understanding of the present application. It will be apparent, however, to one skilled in the art, that these specific details can not be required in every implementation, and that the application can be practiced without such details. In other instances, well-known methods, procedures, components, and networks have not been described in detail as not to unnecessarily obscure pertinent aspects of the implementation. In this specification, the terms“first,”“second,”“third,” etc. are used to distinguish between different elements, devices, modules, etc. and are not used to describe a sequential order or a priority. The terms“first,”“second,” etc. are used arbitrarily and are not used to denote or imply a sequential order or a priority.
[0035] In the following, the technical scheme in the embodiments of the present application will be clearly and completely described in conjunction with the accompanying drawings of the embodiments of the present application. Obviously, the described embodiments are only some of the embodiments of the present application, but not all the embodiments of the present application. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative work fall within the scope of protection of the present application.
[0036] Figure 1 is a flowchart of a prostate targeting puncture method based on mpMRI and ultrasound images provided by an embodiment of the present application. Specifically, the method comprises the following steps:
[0037] S101, acquiring an mpMRI image containing a tumor to be punctured, the mpMRI image comprising a transverse cross-sectional image and a sagittal cross-sectional image;
[0038] In some embodiments, the mpMRI image of the tumor to be punctured is from a subject. The term“subject” or“testee” or“test sample” used herein refers to any animal (e.g., a mammal), including but not limited to a human, a non-human primate, a rodent, etc., who will be the recipient of a particular treatment. Generally, the terms“subject” and“patient” are used interchangeably herein when referring to a human subject. Preferably, the subject is a human.
[0039] S102, defining the median anteroposterior diameter as the y-axis based on the mpMRI image; defining the intersection of the y-axis and the rectal anterior wall (equivalent to the posterior wall of the prostate) as the intersection point, and defining the line passing through the intersection point and perpendicular to the y-axis as the x-axis, and defining the line passing through the intersection point and perpendicular to the y-axis as the z-axis;
[0040] S103, measure the distance a between the intersection point and the center of the tumor to be punctured according to the cross-sectional image (i.e. the π1 image), i.e. the distance between the tumor and the rectal forearm; as shown in Figure 6 A;
[0041] S104, measure the distance b between the lateral edge of the tumor and the edge of the prostate along the z-axis direction according to the sagittal image (i.e. the π2 image); the direction of the line where the distance b is located is parallel to the z-axis; as shown in Figure 6 B;
[0042] In some embodiments, the distance b is the distance between the lateral edge of the tumor and the anterior wall of the prostate rather than the center of the tumor because the biopsy needle does not need to puncture into the center of the tumor.
[0043] S105, determine the target puncture area according to the line where the distance a is located and the line where the distance b is located.
[0044] In some embodiments, the method further comprises:
[0045] measuring the angle θ between the line where the distance a is located and the y-axis; obtaining the ultrasound image of the median sagittal section containing the tumor to be punctured by using the rectal ultrasound probe, rotating the ultrasound probe by the angle θ to obtain the target ultrasound image π3, and positioning the tumor to be punctured and the target puncture area in the target ultrasound image. As shown in Figure 6 C;
[0046] In some embodiments, the target ultrasound image is the cross-sectional image of the tumor to be punctured.
[0047] In some embodiments, the angle θ includes a positive value or a negative value. The angle θ is determined as positive or negative according to the position of the tumor to be punctured, and the positioning of positive or negative is adaptively set according to habit, for example: when the tumor is on the left side, the angle θ can be defined as positive or negative, and correspondingly when the tumor is on the right side, the angle θ can be defined as negative or positive.
[0048] In some embodiments, the method further comprises: performing puncture by using the biopsy needle according to the target ultrasound image, so that the puncture distance reaches the target puncture area; optionally, the puncture distance is less than the distance b because there is a sampling groove in front of the biopsy needle, and the sampling groove can reach the tumor as long as it touches the tumor.
[0049] In some embodiments, the mpMRI image includes T2WI, DWI and DCE images.
[0050] In some embodiments, when the ultrasound probe enters the rectum, the center line of the ultrasound probe is parallel to the z-axis. The z-axis arrow is the direction of the person's foot, and the biopsy needle enters along the z-axis direction in parallel with the probe.
[0051] Figure 3 is a schematic diagram of a computer device provided by an embodiment of the present application, as shown in Figure 3As shown, the device 2000 can include one or more processors 2010, and one or more memories 2020; wherein the memory has stored therein computer readable codes which, when executed by the one or more processors, can perform the method as described above.
[0052] The processor in the embodiment can be an integrated circuit chip with a signal processing capability. The processor can be a general purpose processor, a Digital Signal Processor (DSP), an Application Specific Integrated Circuit (ASIC), a Field Programmable Gate Array (FPGA) or other programmable logic device, discrete gate or transistor logic device, discrete hardware component. The methods, operations and logical block diagrams disclosed in the embodiments of the present disclosure can be implemented or executed by the processor. The general purpose processor can be a microprocessor or the processor can also be any conventional processor, etc., which can be of X86 architecture or ARM architecture.
[0053] In general, the various example embodiments of the present disclosure can be implemented in hardware or special-purpose circuitry, software, firmware, logic, or any combination thereof. Some aspects can be implemented in hardware, while other aspects can be implemented in firmware or software which can be executed by a controller, microprocessor or other computing device. When aspects of the present disclosure are illustrated or described as a block diagram, flow chart, or using some other pictorial representation, it will be understood that the blocks, devices, systems, techniques or methods described herein can be implemented in hardware, software, firmware, special-purpose circuitry, general purpose hardware or controller or other computing device, or some combination thereof.
[0054] For example, the methods or apparatuses according to embodiments of the present disclosure can also be implemented by means of Figure 4 The architecture of the computing device 3000 as shown can be used to implement the methods according to embodiments of the present disclosure. As shown, Figure 4 As shown, the computing device 3000 can include a bus 3010, one or more CPUs 3020, a read-only memory (ROM) 3030, a random access memory (RAM) 3040, a communication port connected to a network 3050, an input / output component 3060, a hard disk 3070, etc. The storage devices in the computing device 3000, such as the ROM 3030 or the hard disk 3070, can store various data or files used in processing and / or communication of the methods provided by the present disclosure, as well as program instructions executed by the CPU. The computing device 3000 can also include a user interface 3080. Of course, Figure 4 The architecture as shown is only exemplary, and when implementing different devices, one or more components in the computing device can be omitted according to actual needs. Figure 4 One or more components in the computing device as shown.
[0055] The embodiments of the present disclosure also provide a computer readable storage medium, such as a floppy disk, an optical disk, a CD-ROM, a magnetic disk, a ROM, a RAM, etc. Figure 5As shown, the computer storage medium 4020 stores computer readable instructions 4010. The computer readable instructions 4010, when executed by a processor, can perform the method according to the embodiments of the present disclosure described with reference to the above drawings. The computer readable storage medium in the embodiments of the present disclosure can be a volatile memory or a non-volatile memory, or can include both volatile and non-volatile memories. The non-volatile memory can be a read-only memory (ROM), a programmable read-only memory (PROM), an erasable programmable read-only memory (EPROM), an electrically erasable programmable read-only memory (EEPROM), or a flash memory. The volatile memory can be a random access memory (RAM) used as an external cache. By way of example, and not limitation, many forms of RAM are available, such as Static Random Access Memory (SRAM), Dynamic Random Access Memory (DRAM), Synchronous Dynamic Random Access Memory (SDRAM), Double Data Rate Synchronous Dynamic Random Access Memory (DDR SDRAM), Enhanced Synchronous Dynamic Random Access Memory (ESDRAM), SynchBurst Dynamic Random Access Memory (SLDRAM), and Direct Rambus Dynamic Random Access Memory (DR RAM). It should be noted that the memory of the method described herein is intended to include, but not be limited to, these and any other suitable types of memory. It should be noted that the memory of the method described herein is intended to include, but not be limited to, these and any other suitable types of memory.
[0056] The embodiments of the present disclosure also provide a computer program product or system, including a computer program, which, when executed by a processor, implements the steps of the above method, such as Figure 2 As shown, the computer program product or computer program includes:
[0057] The image acquisition module 201 is configured to or used to acquire an mpMRI image containing a tumor to be punctured, and the mpMRI image includes a transverse image and a sagittal image.
[0058] The coordinate axis marking module 202 is configured to or used to define a median anteroposterior diameter as a y-axis based on the mpMRI image; define an intersection of the y-axis and a rectal anterior wall as an intersection point; define a line passing through the intersection point and perpendicular to the y-axis as an x-axis; and define a line passing through the intersection point and perpendicular to the y-axis as a z-axis.
[0059] The first measurement module 203 is configured to or used to measure a straight-line distance a between the intersection point and a center of the tumor to be punctured according to the transverse image.
[0060] The second measurement module 204 is configured to or used to measure a straight-line distance b between a lateral edge of the tumor and a prostate edge along a z-axis direction according to the sagittal image, and a direction of the straight line where the distance b is located is parallel to the z-axis.
[0061] The target puncture region determination module 205 is configured to determine the target puncture region according to the straight line where the distance a is located and the straight line where the distance b is located. Specific embodiments
[0062] The present embodiment provides an experimental group and a control group, wherein the control group is transperineal prostate targeted puncture using mpMRI-ultrasound cognitive fusion positioning method: the operator carefully reads the images and reports of the prostate mpMRI examination before the puncture, and the approximate position of the suspicious nodule or suspicious lesion in the prostate is spatially positioned in the brain, and then combined with the real-time dynamic images of transrectal ultrasound during the operation, the two images are formed into cognitive fusion, and then the suspicious lesion is targeted. The experimental group is transperineal prostate targeted puncture guided by the rotation and distance measurement positioning method disclosed in the present embodiment, and the clinical value of the rotation and distance measurement positioning method guided by the combination of multi-parameter MRI and transrectal ultrasound images in transperineal prostate targeted puncture is evaluated.
[0063] Methods: A retrospective analysis was conducted on the clinical data of 142 patients with suspicious lesions found by multiparametric magnetic resonance imaging (mpMRI) and prostate imaging and reporting and data system (PI-RADS) score ≥3 in the Second Hospital of Hebei Medical University from May 2023 to May 2025. All patients underwent diagnostic puncture for the first time. According to the different guiding methods, the patients were divided into the experimental group (68 cases) using the rotation and distance measurement positioning method guided transperineal prostate targeted puncture and the control group (74 cases) based on mpMRI-ultrasound cognitive fusion transperineal prostate targeted puncture. Both groups underwent 12-needle system puncture after targeted puncture. The clinical data, puncture positive rate, and pathological information of the two groups were analyzed.
[0064] Results: In this study, 142 cases, the test group diagnosed 52 cases of prostate cancer (76.47%), the control group diagnosed 44 cases of prostate cancer (59.46%), the difference of prostate cancer detection rate between the two groups was statistically significant (p=0.030). The detection rate of targeted puncture in the test group [70.59%(48 / 68)] was significantly different from that in the control group [52.70%(39 / 74)] (p=0.029). There was no significant difference in the detection rate of systematic puncture between the two groups [47.06% and 41.89% (p=0.536)]. In the subgroup of prostate volume <40 ml, there was no significant difference between the two groups (p>0.05), and in the ≥40 subgroup, the detection rates of prostate cancer in the test group and the control group were [80.56%(29 / 52)] and [57.14%(16 / 44)], respectively, with significant difference (p=0.042). There was no significant difference in the detection rate of prostate cancer and CsPCa in the two groups in the targeted puncture and systematic puncture of different PSA levels and PI-RADS scores (p>0.05). There was no significant difference in the operation time, intraoperative blood loss, puncture VAS score, and postoperative complications between the two groups (p>0.05).
[0065] Conclusion: The combination of mpMRI-ultrasound image and rotation ranging positioning method guided transperineal prostate targeted puncture can improve the positive detection rate of prostate cancer, reduce the misdiagnosis of prostate cancer patients, and provide a new prostate targeted puncture method for clinicians without increasing economic burden and complications.
[0066]
[0067] It should be noted that the flowcharts and block diagrams in the drawings illustrate the possible architectural, functional, and operational architectures of systems, methods, and computer program products according to various embodiments of the present disclosure. In this regard, each block in the flowcharts or block diagrams can represent a module, a program segment, or a portion of code that contains one or more executable instructions for implementing the specified functions. It should also be noted that in some alternative implementations, the functions noted in the blocks can occur in different orders than those noted in the drawings. For example, two blocks that are shown in succession can actually be executed substantially in parallel, and sometimes they can be executed in reverse order, depending on the involved functions. It should also be noted that each block in the block diagrams and / or flowcharts, and the combination of blocks in the block diagrams and / or flowcharts, can be implemented by a dedicated hardware-based system that performs the specified functions or operations, or can be implemented by a combination of dedicated hardware and computer instructions.
[0068] The example embodiments of the present disclosure described in detail above are merely illustrative, rather than restrictive. It should be understood by those skilled in the art that various modifications and combinations can be made to the embodiments or features thereof without departing from the principles and spirit of the present disclosure, and such modifications should fall within the scope of the present disclosure.
Claims
1. A prostate-targeted biopsy method based on a combination of mpMRI and ultrasound imaging, characterized in that, The methods include: S101, acquire mpMRI images containing the tumor to be punctured. The mpMRI images include transverse and sagittal images. S102, based on the mpMRI image, the midline anteroposterior diameter is defined as the y-axis; the intersection of the y-axis and the anterior wall of the rectum is defined as the intersection point; the line passing through the intersection point and perpendicular to the y-axis is defined as the x-axis; and the line passing through the intersection point and perpendicular to the y-axis is defined as the z-axis. S103, Measure the straight-line distance a between the intersection point and the center of the tumor to be punctured based on the cross-sectional image; S104, Measure the straight-line distance b from the outer edge of the tumor to the edge of the prostate along the z-axis direction based on the sagittal image; the straight-line direction of distance b is parallel to the z-axis; S105, determine the target puncture area based on the straight line containing distance a and the straight line containing distance b.
2. The prostate targeted puncture method based on the combination of mpMRI and ultrasound imaging according to claim 1, characterized in that, The method further includes: Measure the angle θ between the line containing distance a and the y-axis; A rectal ultrasound probe is used to acquire an ultrasound image of the midline sagittal section containing the tumor to be punctured. The ultrasound probe is rotated by an angle θ to obtain a target ultrasound image. The tumor to be punctured and the target puncture area are located in the target ultrasound image.
3. The prostate targeted puncture method based on the combination of mpMRI and ultrasound imaging according to claim 2, characterized in that, The included angle θ can be positive or negative.
4. The prostate targeted puncture method based on the combination of mpMRI and ultrasound imaging according to claim 2, characterized in that, The target ultrasound image is a cross-sectional image of the tumor to be punctured.
5. The prostate targeted puncture method based on the combination of mpMRI and ultrasound imaging according to claim 2, characterized in that, The method further includes: based on the target ultrasound image, using a biopsy needle to perform a puncture distance to reach the target puncture area; Optionally, the puncture distance is less than distance b.
6. The prostate targeted puncture method based on the combination of mpMRI and ultrasound imaging according to claim 1, characterized in that, The mpMRI images include T2WI, DWI, and DCE images.
7. The prostate targeted puncture method based on mpMRI and ultrasound imaging as described in claim 2, characterized in that, When the ultrasound probe enters the rectum, the center line of the ultrasound probe is parallel to the z-axis.
8. A computer device, characterized in that, The device includes: a memory and a processor; the memory is used to store a computer program; the processor executes the computer program to implement the steps of the method according to any one of claims 1-7.
9. A computer-readable storage medium, characterized in that, It stores a computer program that, when executed by a processor, implements the steps of the method as described in any one of claims 1-7.
10. A computer program product, comprising a computer program, characterized in that, When executed by a processor, the computer program implements the steps of the method described in any one of claims 1-7.