Cosmetic composition for repairing photodamage with broad-spectrum uv protection and cosmetic photoreversal and uses thereof

Abstract

The present application provides a kind of broad-spectrum UV protection and cosmetic light reverse light damage repair cosmetic composition and its application, belong to the cosmetic technical field.The cosmetic composition of the present application includes: photoactivated enzyme repair factor, ginger flower root extract and white water lily flower extract;The composition also includes QUERCARE light-resistant substance.The photoactivated enzyme repair factor, ginger flower root extract and white water lily flower extract of the present application are compounded, accelerate light damage recovery, improve sunscreen product performance, reduce adverse reactions after sun exposure, have the effect of soothing and whitening, light-resistant substance not only absorbs ultraviolet rays, and is converted into cosmetic light, from the source, the light that is harmful to skin is converted into the light that is beneficial to skin, has anti-inflammatory soothing effect, reduces collagen degradation, inhibits DNA damage and mutation, reduces cell nucleus senescence, inhibits oil secretion.The cosmetic composition of the present application is suitable for high sunscreen demand and anti-photoaging skin care products, has the function of immediate protection and long-term repair.

Description

Technical Field

[0001] This invention relates to the field of cosmetic technology, specifically to a cosmetic composition for broad-spectrum UV protection and cosmetic light reversal and repair of photodamage, and its application. Background Technology

[0002] With increasing environmental pollution and ozone layer depletion, ultraviolet (UV) radiation is causing increasingly severe damage to human skin. UVA (320-400 nm) and UVB (280-320 nm) rays can penetrate different depths of the skin, triggering photoaging, pigmentation, inflammation, and even skin cancer. Long-term exposure to UV radiation leads to collagen degradation, elastin fiber breakage, and free radical accumulation, accelerating skin aging. Furthermore, visible light and infrared radiation (IRA) may also exacerbate photodamage by inducing oxidative stress. Therefore, developing cosmetics that combine broad-spectrum UV protection with photodamage repair has become a research hotspot.

[0003] Currently, sunscreens on the market primarily rely on chemical and physical sunscreens to block or absorb ultraviolet (UV) rays. However, traditional sunscreens have limitations: they can cause skin irritation or photosensitivity reactions; physical sunscreens tend to leave a white cast, affecting the user experience; they only focus on UVB protection, offering insufficient protection against UVA and visible light; and they lack the ability to repair existing photodamage. Common active ingredients for photodamage repair include antioxidants, plant extracts, and cell repair factors. These ingredients reduce photodamage by scavenging free radicals, inhibiting inflammation, or promoting collagen synthesis, but their effectiveness is limited by poor stability, low transdermal absorption, or a single mechanism of action.

[0004] Therefore, it is of great significance to develop a cosmetic composition that combines broad-spectrum UV protection, high-efficiency antioxidant properties, and photodamage reversal. Summary of the Invention

[0005] The purpose of this invention is to provide a cosmetic composition for broad-spectrum UV protection and photoreversal and photodamage repair, and its application. The cosmetic composition provided by this invention can provide comprehensive UV protection and has a photodamage repair effect; the composition can be used as a cosmetic ingredient to give cosmetic products excellent effects.

[0006] To achieve the above-mentioned objectives, the present invention provides the following technical solution:

[0007] This invention provides a cosmetic composition for broad-spectrum UV protection and cosmetic light-reversal and photodamage repair, comprising photoactivated enzyme repair factor, ginger flower root extract and white water lily extract.

[0008] Preferably, the weight ratio of the photoactivated enzyme repair factor, ginger flower root extract and white water lily extract is (0.3-0.5):(4-6):(2-4).

[0009] Preferred options also include QUERCARE.

[0010] More preferably, the weight ratio of QUERCARE to photoactivated enzyme repair factor, ginger root extract and white water lily extract is (0.3-0.5):(0.3-0.5):(4-6):(2-4).

[0011] Preferred options also include chemical sunscreens, physical sunscreens, and photodamage repair agents.

[0012] More preferably, the photodamage repair agent is composed of rockrose leaf extract, Ganoderma lucidum extract and hydrolyzed red algae extract.

[0013] More preferably, physical sunscreens consist of titanium dioxide and silica.

[0014] Preferably, it also includes excipients acceptable in cosmetics.

[0015] The present invention also provides the application of the above-mentioned cosmetic composition in sunscreen cosmetics.

[0016] The present invention also provides the application of the above-mentioned cosmetic composition in photodamage repair cosmetics.

[0017] Compared with the prior art, the present invention has the following beneficial effects:

[0018] This invention provides a cosmetic composition for broad-spectrum UV protection and photoreversal and photodamage repair, comprising: photoactivated enzyme repair factor, ginger flower root extract and white water lily extract; and further comprising QUERCARE, physical sunscreen, chemical sunscreen and photodamage repair agent, wherein the photodamage repair agent is composed of rockrose leaf extract, Ganoderma lucidum extract and hydrolyzed red algae extract. This invention scientifically combines three active ingredients—photoactivated enzyme repair factor, ginger flower root extract, and white water lily extract—to enhance the UV defense system, accelerate photodamage recovery, combat photoaging, delay skin aging, improve sunscreen efficacy, and soothe and whiten the skin. Through the synergistic effect of physical and chemical sunscreens, it covers a wider range of UV wavelengths, effectively blocking and absorbing UV rays, providing comprehensive UV protection and preventing sunburn, tanning, and photoaging caused by UV radiation. The photodamage repair agent forms a complete "defense-repair-reversal" photodamage repair system, comprehensively addressing photoaging caused by environmental factors such as UVA / UVB, blue light, and pollution, while promoting skin barrier repair and rejuvenation. This cosmetic composition is suitable for skincare products with high sun protection needs and anti-photoaging properties, offering both immediate protection and long-term repair. Detailed Implementation

[0019] This invention provides a cosmetic composition for broad-spectrum UV protection and cosmetic light-reversal and repair of photodamage, characterized in that it comprises photoactivated enzyme repair factor, ginger flower root extract and white water lily extract.

[0020] The preferred weight ratio of the photoactivated enzyme repair factor, ginger flower root extract and white water lily extract in this invention is (0.3-0.5):(4-6):(2-4), and more preferably 0.4:5:3.

[0021] This invention's photoactivated enzyme repair factor can specifically target and repair cyclobutane pyrimidine dimers; it is activated by light and can rapidly and completely repair damaged DNA; the enzyme can repeatedly participate in the reaction, with photolyase acting as a catalyst in the repair process, its properties remaining unchanged, and it can cyclically participate in the repair; it can eliminate reactive oxygen species generated by ultraviolet radiation; it has a calming and soothing effect, enhancing immunity and reducing post-sun pain by reducing the expression of pro-inflammatory cytokines; it reduces the content of metalloproteinases to prevent wrinkle formation and combat photoaging; it can be used with sunscreen ingredients to enhance the protective ability of sunscreens. Ginger flower root extract can scavenge free radicals, reduce photo-oxidative damage, inhibit MMP-1 activity to protect collagen, and reduce the formation of AGEs (advanced glycation end products), thereby delaying skin yellowing; more importantly, it can provide multiple protections for the skin against aging (UVA model) and external pollution (blue light and benzo[a]pyrene model), significantly improving abnormal skin energy metabolism caused by UVA. White water lily extract can enhance the skin's defenses, soothe skin tissue by reducing inflammation, relieve skin discomfort caused by sunlight and chemical irritants, and reduce pigmentation caused by inflammatory stress, thereby achieving a skin-whitening effect.

[0022] This invention scientifically combines three active ingredients—photoactivated enzyme repair factor, ginger flower root extract, and white water lily extract—to enhance the UV defense system, forming a triple protective network of "instant repair (DNA) + anti-oxidation (free radicals) + anti-inflammation (barrier protection)," covering different stages of UV-induced damage (acute damage, oxidative stress, and chronic inflammation), achieving comprehensive repair from the molecular to the tissue level; accelerating the recovery from photodamage, achieving comprehensive repair from the molecular to the tissue level; simultaneously targeting the three major photoaging pathways of "collagen degradation + glycation + pigmentation," which is more comprehensive than single-ingredient products; improving the efficacy of sunscreen products, compensating for the shortcomings of traditional sunscreens; reducing adverse reactions after sun exposure, and having soothing and whitening effects.

[0023] The present invention preferably includes 0.3-0.5 parts by weight of QUERCARE. On the one hand, the absorption peak of QUERCARE highly overlaps with UVA and UVB, and can absorb ultraviolet rays and convert them into cosmetic light, transforming skin-damaging light into skin-beneficial light from the source; on the other hand, QUERCARE has strong antioxidant, anti-inflammatory and soothing effects, protects the integrity and density of the stratum corneum, protects the thickness and density of the granular layer and spinous layer, reduces collagen degradation caused by UVB, inhibits DNA damage and mutation caused by ultraviolet rays, reduces cell nuclear aging caused by ultraviolet rays, and inhibits sebum secretion.

[0024] The present invention also includes chemical sunscreens, physical sunscreens, and photodamage repair agents.

[0025] The chemical sunscreen agent of this invention is preferably composed of bis-ethylhexyloxyphenol methoxyphenyl triazine, avobenzone, and octocrylene in a weight ratio of (2-4):(1-3):(3-5), more preferably 3:2:4. Bis-ethylhexyloxyphenol methoxyphenyl triazine provides all-around protection by absorbing, scattering, and reflecting ultraviolet rays, and is not absorbed by the skin; it stabilizes avobenzone and reduces photodegradation. Avobenzone is a broad-spectrum UVA absorber. Octoccrylene improves the spreadability of cosmetic compositions and significantly enhances the photostability of UVA sunscreen agents such as avobenzone, thereby improving overall sun protection efficacy. The combination of these three agents achieves full-spectrum coverage, improves sun protection effect, and bis-ethylhexyloxyphenol methoxyphenyl triazine and octocrylene stabilize avobenzone to prevent photodegradation.

[0026] The physical sunscreen agent of this invention is preferably composed of titanium dioxide and silica, and the weight ratio of titanium dioxide to silica is preferably 40-45:55-60, more preferably 42:58. This physical sunscreen agent can improve SPF value, reduce shine, has an ultra-light texture, enhance transparency, and has good compatibility with thickeners.

[0027] The photodamage repair agent of the present invention is composed of rockrose leaf extract, Ganoderma lucidum extract and hydrolyzed red algae extract.

[0028] The rockrose leaf extract of this invention is obtained through ethanol-microwave extraction. This rockrose leaf extract possesses photoprotective, anti-pollution and antioxidant, skin repair and renewal promoting, anti-aging, and skin texture improvement effects. Photoprotective effects include resisting blue light damage: reducing collagen degradation caused by blue light from electronic devices, inhibiting the activity of matrix metalloproteinase MMP-1, protecting dermal structure, and protecting against UVA / UVB: scavenging free radicals, reducing oxidative stress, preventing lipid peroxidation; reducing DNA damage, promoting DNA repair gene expression, and reducing inflammatory factors. Anti-pollution and antioxidant effects: neutralizing oxidative stress synergistically induced by air pollutants and UVA, reducing cell membrane damage, and possessing potent antioxidant activity. Skin repair and renewal promotion: shortening the epidermal renewal cycle, helping the skin recover quickly, enhancing skin recovery ability, improving skin barrier function, and repairing after photodamage. Anti-aging and skin texture improvement: reducing wrinkles and fine lines, making the skin smoother by promoting collagen protection and reducing inflammation.

[0029] The Ganoderma lucidum extract of this invention is obtained through enzymatic hydrolysis with a complex enzyme. This Ganoderma lucidum extract regulates sensory receptors, helping to relieve discomfort; reduces the content of inflammatory markers, thus reducing local inflammation; it can increase the synthesis of filaggrin, improving moisturizing effects and enhancing the skin barrier; it has immediate and long-lasting moisturizing effects, immediate relief of stinging, and immediate reduction of redness.

[0030] The hydrolyzed red algae extract of this invention is obtained through aerobic fermentation with *Lactobacillus paracasei* CICC 25261 and anaerobic fermentation with *Bifidobacterium adolescentis* CICC 24573. This hydrolyzed red algae extract achieves skin aging reversal at the cellular level through a triple mechanism of reversing cellular aging, activating autophagy, and repairing photodamage. It is particularly suitable for improving deep wrinkles, sagging, and photoaging problems. Reversing cellular aging: It reduces the release of pro-inflammatory factors, blocks inflammatory damage to surrounding tissues, degrades key aging factors, reduces the expression of aging cell markers, and restores cells to a youthful state. Activating autophagy and cellular energy: It enhances the expression of autophagy markers, clears damaged organelles and metabolic waste, and enhances autophagy activity; it increases cellular energy, improves mitochondrial function, and restores cellular metabolic vitality. Repairing photoaging and oxidative damage: It scavenge hydroxyl free radicals, inhibits ROS and lipid peroxidation; it protects collagen and hyaluronic acid, reduces collagen degradation, promotes the synthesis of type I procollagen and hyaluronic acid, and improves the structure of the dermis.

[0031] The photodamage repair agent of this invention combines rockrose leaf extract, Ganoderma lucidum extract and hydrolyzed red algae extract to form a full-chain photodamage repair system of "defense-repair-reversal". It can comprehensively address the skin photoaging problems caused by environmental factors such as ultraviolet rays (UVA / UVB), blue light, and pollution, while promoting skin barrier repair and rejuvenation.

[0032] The moisturizer, antioxidant, emulsifier, film-forming agent, and preservative described in this invention are all selected from raw materials known in the cosmetics field. As a preferred embodiment, the moisturizer includes, but is not limited to, at least one of glycerin, sorbitol, betaine, and panthenol; the antioxidant includes, but is not limited to, ascorbic acid, tocopherol, and ferulic acid; the emulsifier includes, but is not limited to, at least one of stearyl alcohol polyether-2, stearyl alcohol polyether-21, and PEG-40 stearate; the film-forming agent includes, but is not limited to, at least one of VP / eicosene copolymer, polyvinylpyrrolidone K30, and polymethylsilsesquioxane; the preservative includes, but is not limited to, at least one of phenoxyethanol, ethylhexylglycerin, and 1,2-pentanediol; and the solvent is preferably water.

[0033] The method of using the cosmetic composition of the present invention is as follows: After cleansing and basic skin care, take a coin-sized amount (about 0.9g) of the cosmetic composition and apply it to five areas, namely the cheeks, forehead, nose tip, and chin, with your fingertips. Massage it evenly in a clockwise circular motion in the same direction until it forms a film.

[0034] The present invention also provides the application of the above-mentioned cosmetic composition in sunscreen cosmetics.

[0035] The present invention also provides the application of the above-mentioned cosmetic composition in photodamage repair cosmetics.

[0036] The technical solutions of this invention will be clearly and completely described below with reference to the embodiments thereof. Obviously, the described embodiments are only a part of the embodiments of this invention, and not all of them. All other embodiments obtained by those skilled in the art based on the embodiments of this invention without creative effort are within the scope of protection of this invention.

[0037] Unless otherwise specified, the following embodiments are all conventional methods.

[0038] Unless otherwise specified, all materials and reagents used in the following examples are commercially available.

[0039] Photoactivated enzyme repair factor is ALGAKTIV ®GenoFix CPD photoactivated enzyme repair factor, disclosed in international patent number WO2017013183A1, INCI name: Spirulina maxima extract / lecithin / 1,3-propanediol / water, purchased from Guangzhou Bochi Biotechnology Co., Ltd.; polyvinylpyrrolidone K30 purchased from Anhui Weimao Biotechnology Co., Ltd., item number 6686686645; stearyl alcohol polyether-2 purchased from Guangzhou Chennuo Biotechnology Co., Ltd., item number ET85237; stearyl alcohol polyether-21 purchased from Yichang Mingya New Material Technology Co., Ltd., item number MY972-B; polysiloxane quaternary ammonium salt-12 purchased from Guangdong Wengjiang Chemical Reagent Co., Ltd., item number PB90591; VP / eicosene copolymer purchased from Guangzhou Bao Long International Trade Co., Ltd., item number V-220F; cellulase purchased from Qingdao Weisen Biotechnology Co., Ltd., enzyme activity 100,000 U / g, item number X5641; pectinase purchased from Ningxia Xiasheng Industrial Group Co., Ltd., enzyme activity 60,000 U / g, item number FDY-2212; QUERCARE™, purchased from Shanghai Huiwen Biotechnology Co., Ltd.; ginger root extract from Guangzhou Baihaobo Co., Ltd.; white water lily extract from Seppic, France; chamomile extract, calendula extract and licorice extract were all purchased from Shanxi Baohe Biotechnology Co., Ltd., item numbers sxbb389869893, SXBBGGYTQY and sxbb789489384112 respectively.

[0040] Example 1

[0041] Cosmetic compositions for broad-spectrum UV protection and photoreversal and repair of photodamage.

[0042] Accurately weigh 0.4 parts of photoactivating enzyme repair factor, 5 parts of ginger flower root extract, 3 parts of white water lily extract, and 0.4 parts of QUERCARE light-protecting agent according to the specified weight; mix the above components to obtain a cosmetic composition.

[0043] Example 2

[0044] Cosmetic compositions for broad-spectrum UV protection and photoreversal and repair of photodamage.

[0045] Accurately weigh 0.3 parts of photoactivating enzyme repair factor, 6 parts of ginger flower root extract, 2 parts of white water lily extract, and 0.5 parts of QUERCARE light-protecting agent according to the specified weight; mix the above components to obtain a cosmetic composition.

[0046] Example 3

[0047] Cosmetic compositions for broad-spectrum UV protection and photoreversal and repair of photodamage.

[0048] Accurately weigh 0.5 parts of photoactivating enzyme repair factor, 4 parts of ginger flower root extract, 4 parts of white water lily extract, and 0.3 parts of QUERCARE light-protecting agent according to the weight ratio; mix the above components to obtain a cosmetic composition.

[0049] Experimental Example 1

[0050] Animal experiments

[0051] Healthy SKH-1 hairless mice, weighing 20-25g and 8 weeks old, were selected, with an equal number of males and females. The mice were housed in a standard environment with a temperature controlled at 22-25℃, humidity maintained at 50%-60%, and a light cycle of 12 hours of light followed by 12 hours of darkness. They had free access to food and water. Experiments began after the mice had acclimatized to the environment for one week to minimize the impact of environmental changes on the experimental results.

[0052] Preparation of the emulsion in the example: 5 parts by weight of the example composition, 65 parts by weight of deionized water, 20 parts by weight of liquid paraffin, 8 parts by weight of Tween-80 and 2 parts by weight of glycerin; mix the example composition, deionized water and glycerin to obtain an aqueous phase; mix the liquid paraffin and Tween-80 to obtain an oil phase; pour the oil phase into the aqueous phase and stir at 600 rpm for 10 min to obtain the example emulsion.

[0053] Mice were randomly divided into 6 groups of 10 mice each, as follows:

[0054] Blank control group: No ultraviolet radiation treatment or cosmetics were applied; the animals were simply raised under the same conditions.

[0055] Model control group: exposed to ultraviolet light only, without applying cosmetics.

[0056] Positive control group: 30 minutes before ultraviolet irradiation, 0.2g of Shiseido Anessa was applied to the back of mice, followed by ultraviolet irradiation.

[0057] Example 1 group: 30 minutes before ultraviolet irradiation, 0.2g of the emulsion of the composition of Example 1 was applied to the back of mice, and then ultraviolet irradiation was performed.

[0058] Example 2 group: 30 minutes before ultraviolet irradiation, 0.2g of the emulsion of the composition of Example 2 was applied to the back of mice, and then ultraviolet irradiation was performed.

[0059] Example 3 group: 30 minutes before ultraviolet irradiation, 0.2g of the emulsion of the composition of Example 3 was applied to the back of mice, and then ultraviolet irradiation was performed.

[0060] Ultraviolet lamps were used as the light source, primarily emitting medium-wave ultraviolet (UVB) radiation with a wavelength range of 280-320 nm. By adjusting the distance between the mice and the ultraviolet lamps, the irradiation intensity was controlled within a certain range, which was measured to be 0.5 mW / cm². 2 Irradiate 3 times a week, 30 minutes each time, for 4 consecutive weeks.

[0061] (1) Subjective scores and skin erythema index

[0062] The appearance of erythema, desquamation, and wrinkles on the skin of mice in each group were scored according to the following criteria:

[0063] Erythema: 0 points for no erythema, 1 point for mild erythema, 2 points for moderate erythema, and 3 points for severe erythema.

[0064] Desquamation: 0 points for no desquamation, 1 point for slight desquamation, 2 points for moderate desquamation, and 3 points for severe desquamation.

[0065] Wrinkles: 0 points for no wrinkles, 1 point for slight wrinkles, 2 points for moderate wrinkles, and 3 points for severe wrinkles.

[0066] Scoring: Scoring was conducted 24 hours after the experiment ended (the last ultraviolet irradiation). The scores were given independently by 5 professionals, and the average score was taken.

[0067] After scoring, the skin erythema index on the back of the mice was measured using a skin tester and the skin spectroscopy method.

[0068] The subjective scores and skin erythema index results are shown in Table 1.

[0069] Table 1. Subjective scores and skin erythema index results for each group.

[0070] Group Erythema (divided) Desquamation (in parts) Wrinkles (points) Total Score Erythema Index Blank control group 0 0 0 0 16.5 Model group 2.3 2.1 1.7 6.1 42.3 Positive control group 0.6 0.5 0.4 1.5 19.7 Example 1 Group 0.5 0.4 0.3 1.2 17.3 Example 2 group 0.5 0.5 0.5 1.5 17.8 Example 3 Group 0.6 0.4 0.4 1.4 18.2

[0071] As shown in Table 1, compared with the blank control group, the model group showed obvious erythema, desquamation, and photoaging wrinkles, and the erythema index was significantly increased, indicating that the mouse model was successfully constructed. The positive control group showed mild skin damage. The erythema, desquamation, and wrinkles in the Example 1-3 groups were significantly improved compared with the model group, and the erythema index was significantly reduced. The Example 1 group had the best effect and was higher than the subjective score of the positive control group. This may be because the examples contained soothing and repairing ingredients in addition to sunscreen ingredients, which can accelerate the recovery of photodamage and reduce adverse reactions after sun exposure.

[0072] (2) Oxidative stress indicators

[0073] After measuring the skin erythema index, mice were euthanized by cervical dislocation, and intact skin tissue from the irradiated area was harvested. Excess fat and other connective tissues were removed, and the activities of SOD, GSH-Px, and MDA in the skin tissue were measured according to the method provided in the kit. The specific results are shown in Table 2.

[0074] Table 2. Oxidative stress indicators of mice in each group

[0075] Group SOD activity (U / mg prot) GSH-Px activity (U / mg prot) MDA (nmol / mg prot) Blank control group 118.71 55.82 4.31 Model group 62.38 33.06 8.85 Positive control group 98.60 50.41 4.92 Example 1 Group 103.04 52.19 4.56 Example 2 group 100.25 50.75 4.84 Example 3 Group 99.29 51.03 4.72

[0076] As shown in Table 2, the model group exhibited significantly reduced SOD and GSH-Px activities and significantly increased MDA content, showing a clear difference from the blank control group, indicating the successful establishment of the mouse model. Examples 1-3 demonstrated superior effects compared to the positive control group in increasing SOD and GSH-Px activities and reducing MDA content, suggesting that the compositions in these examples can exert a repairing effect by enhancing endogenous antioxidant enzyme activity and inhibiting lipid peroxidation.

[0077] Example 4

[0078] (1) Preparation of photodamage repair agent

[0079] Preparation of rockrose leaf extract: dried and pulverized rockrose leaves were passed through a 200-mesh sieve. A 60% ethanol solution was added at a material-to-liquid ratio of 1:20 g / mL. The mixture was microwave extracted for 20 min at 400 W, 60 °C, and pH 5.5. The extract was then filtered, concentrated, and dried to a water content of 4 wt% to obtain the rockrose leaf extract.

[0080] Preparation of Ganoderma lucidum extract: Grind the fruiting bodies of Ganoderma lucidum to obtain ground material 1. Mix it with water at a material-to-liquid ratio of 1:10 g / mL. Add 2% by weight of compound enzyme to ground material 1 and enzymatically hydrolyze it at 55℃ and pH 4.8 for 30 min. Filter the mixture, concentrate the filtrate, and dry it to a water content of 2 wt% to obtain Ganoderma lucidum extract. The compound enzyme is composed of cellulase and pectinase at a weight ratio of 3:1.

[0081] Preparation of hydrolyzed red algae extract: Grind hot spring red algae to obtain ground material 2, add water at a material-to-liquid ratio of 1:30 g / mL, sterilize, and inoculate with 3×10⁻⁶ live bacteria. 9 Lactobacillus paracasei CICC 25261, at cfu / mL, was aerobic fermented for 36 h at 37℃, pH 6.8, and 200 rpm. The inoculum viable was 5 × 10⁻⁶. 9Bifidobacterium adolescentis CICC 24573 (cfu / mL) was anaerobic fermented at 37℃ and pH 7 for 60 h, sterilized, filtered, and the filtrate was concentrated and dried to a water content of 4 wt% to obtain a hydrolyzed red algae extract. The inoculum of Lactobacillus paracasei CICC 25261 was 1.5% of the weight of the ground material 2, and the inoculum of Bifidobacterium adolescentis CICC 24573 was 2% of the weight of the ground material 2.

[0082] A photodamage repair agent was obtained by mixing rock rose leaf extract, Ganoderma lucidum extract and hydrolyzed red algae extract in a weight ratio of 0.005:0.1:2.

[0083] (2) Preparation of cosmetic compositions for broad-spectrum UV protection and cosmetic photoreversal and photodamage repair

[0084] Titanium dioxide and silica are mixed in a weight ratio of 42:58 to obtain a physical sunscreen.

[0085] A chemical sunscreen agent was obtained by mixing bis-ethylhexyloxyphenol methoxyphenyl triazine, avobenzone and octocrylene in a weight ratio of 3:2:4.

[0086] Accurately weigh the following components per 100 parts by weight: 8 parts physical sunscreen, 12 parts chemical sunscreen, 0.4 parts photoactivated enzyme repair factor, 5 parts ginger flower root extract, 3 parts white water lily extract, 0.4 parts QUERCARE light-protecting agent, 2.105 parts photodamage repair agent, 3 parts glycerin, 2 parts panthenol, 1 part ascorbic acid, 0.5 parts ferulic acid, 1 part stearyl alcohol polyether-2, 1 part stearyl alcohol polyether-21, 3 parts polyvinylpyrrolidone K30, 0.2 parts phenoxyethanol, and the balance being water.

[0087] A physical sunscreen agent was mixed with 16 parts by weight of water and sonicated at 150W for 25 min to obtain a physical sunscreen agent dispersion. A chemical sunscreen agent, ascorbic acid, ferulic acid, stearyl alcohol polyether-2, and stearyl alcohol polyether-21 were mixed and heated at 70°C for 10 min to obtain an oil phase. The remaining water, glycerin, panthenol, polyvinylpyrrolidone K30, and phenoxyethanol were mixed to obtain an aqueous phase. The oil phase was added to the aqueous phase and homogenized at 8000 rpm for 5 min. The physical sunscreen agent dispersion was then added and homogenized at 5000 rpm for 2 min. Photoactivated enzyme repair factor, ginger flower root extract, white water lily extract, QUERCARE light-protecting agent, and photodamage repair agent were added. The mixture was stirred at 200 rpm for 20 min, the pH was adjusted to 6.3, and the mixture was degassed under vacuum and sterilized to obtain a cosmetic composition.

[0088] Example 5

[0089] (1) Preparation of photodamage repair agent

[0090] Preparation of rockrose leaf extract: dried and pulverized rockrose leaves were passed through a 150-mesh sieve. A 58% ethanol solution was added at a material-to-liquid ratio of 1:18 g / mL. The mixture was microwave extracted for 25 min at 350 W, 58 °C, and pH 5.2. The extract was then filtered, concentrated, and dried to a water content of 3 wt% to obtain the rockrose leaf extract.

[0091] Preparation of Ganoderma lucidum extract: Grind the fruiting bodies of Ganoderma lucidum to obtain ground material 1. Mix it with water at a material-to-liquid ratio of 1:10 g / mL. Add 2% by weight of compound enzyme to ground material 1 and enzymatically hydrolyze it at 55℃ and pH 4.5 for 35 min. Filter the mixture, concentrate the filtrate, and dry it to a water content of 3 wt% to obtain Ganoderma lucidum extract. The compound enzyme consists of cellulase and pectinase at a weight ratio of 2:0.5.

[0092] Preparation of hydrolyzed red algae extract: Grind hot spring red algae to obtain ground material 2, add water at a material-to-liquid ratio of 1:25 g / mL, sterilize, and inoculate with 2×10⁻⁶ live bacteria. 9 Lactobacillus paracasei CICC 25261, at cfu / mL, was aerobic fermented for 48 h at 35℃, pH 6.5, and 150 rpm. The inoculum viable was 4 × 10⁻⁶. 9 Bifidobacterium adolescentis CICC 24573 (cfu / mL) was anaerobic fermented at 35℃ and pH 6.7 for 72 h, sterilized, filtered, and the filtrate was concentrated and dried to a water content of 2 wt% to obtain a hydrolyzed red algae extract. The inoculum amount of Lactobacillus paracasei CICC 25261 was 1% of the weight of the ground material 2, and the inoculum amount of Bifidobacterium adolescentis CICC 24573 was 1.5% of the weight of the ground material 2.

[0093] A photodamage repair agent was obtained by mixing rock rose leaf extract, Ganoderma lucidum extract and hydrolyzed red algae extract in a weight ratio of 0.01:0.12:1.

[0094] (2) Preparation of cosmetic compositions for broad-spectrum UV protection and cosmetic photoreversal and photodamage repair

[0095] Titanium dioxide and silica are mixed in a weight ratio of 40:60 to obtain a physical sunscreen.

[0096] A chemical sunscreen agent was obtained by mixing bis-ethylhexyloxyphenol methoxyphenyl triazine, avobenzone and octocrylene in a weight ratio of 2:1:3.

[0097] Accurately weigh the following components per 100 parts by weight: 5 parts physical sunscreen, 15 parts chemical sunscreen, 0.3 parts photoactivated enzyme repair factor, 6 parts ginger flower root extract, 2 parts white water lily extract, 0.5 parts QUERCARE light-protecting agent, 1.13 parts photodamage repair agent, 5 parts glycerin, 2 parts sorbitol, 0.5 parts ascorbic acid, 0.5 parts tocopherol, 3 parts PEG-40 stearate, 2 parts VP / eicosene copolymer, 0.3 parts ethylhexylglycerin, and the balance being water.

[0098] A physical sunscreen agent was mixed with 15 parts by weight of water and sonicated at 120W for 30 min to obtain a physical sunscreen agent dispersion. A chemical sunscreen agent, ascorbic acid, tocopherol, PEG-40 stearate, and VP / eicosene copolymer were mixed and heated at 65°C for 15 min to obtain an oil phase. The remaining water, glycerin, sorbitol, and ethylhexylglycerin were mixed to obtain an aqueous phase. The oil phase was added to the aqueous phase and homogenized at 7500 rpm for 6 min. The physical sunscreen agent dispersion was added and homogenized at 4000 rpm for 3 min. Photoactivated enzyme repair factor, ginger flower root extract, white water lily extract, QUERCARE light-protecting agent, and photodamage repair agent were added. The mixture was stirred at 180 rpm for 30 min, the pH was adjusted to 6, and the mixture was degassed under vacuum and sterilized to obtain a cosmetic composition.

[0099] Example 6

[0100] (1) Preparation of photodamage repair agent

[0101] Preparation of rockrose leaf extract: dried and pulverized rockrose leaves were passed through a 250-mesh sieve. A 65% ethanol solution was added at a material-to-liquid ratio of 1:23 g / mL. The extract was then microwaved at 450 W, 65 °C, and pH 5.8 for 18 min. The extract was filtered, concentrated, and dried to a water content of 3 wt% to obtain the rockrose leaf extract.

[0102] Preparation of Ganoderma lucidum extract: Grind the fruiting body of Ganoderma lucidum to obtain ground material 1. Mix it with water at a material-to-liquid ratio of 1:12 g / mL. Add 3% by weight of compound enzyme to ground material 1 and enzymatically hydrolyze it at 58℃ and pH5 for 25 min. Filter the mixture, concentrate the filtrate, and dry it to a water content of 3wt% to obtain Ganoderma lucidum extract. The compound enzyme is composed of cellulase and pectinase at a weight ratio of 4:3.

[0103] Preparation of hydrolyzed red algae extract: Hot spring red algae were ground to obtain ground material 2. Water was added at a material-to-liquid ratio of 1:32 g / mL, sterilized, and inoculated with 4×10⁻⁶ live bacteria. 9 Lactobacillus paracasei CICC 25261, at cfu / mL, was aerobic fermented for 30 h at 38℃, pH 7, and 250 rpm. The inoculum viable count was 6 × 10⁶. 9Bifidobacterium adolescentis CICC 24573 (cfu / mL) was anaerobic fermented at 38℃ and pH 7.2 for 55 h, sterilized, filtered, and the filtrate was concentrated and dried to a water content of 3 wt% to obtain a hydrolyzed red algae extract. The inoculum amount of Lactobacillus paracasei CICC 25261 was 1% of the weight of the ground material 2, and the inoculum amount of Bifidobacterium adolescentis CICC 24573 was 1.5% of the weight of the ground material 2.

[0104] A photodamage repair agent was obtained by mixing rock rose leaf extract, Ganoderma lucidum extract and hydrolyzed red algae extract in a weight ratio of 0.003:0.08:3.

[0105] (2) Preparation of cosmetic compositions for broad-spectrum UV protection and cosmetic photoreversal and photodamage repair

[0106] Titanium dioxide and silica are mixed in a weight ratio of 45:55 to obtain a physical sunscreen.

[0107] A chemical sunscreen agent was obtained by mixing bis-ethylhexyloxyphenol methoxyphenyl triazine, avobenzone and octocrylene in a weight ratio of 4:3:5.

[0108] Accurately weigh the following components per 100 parts by weight: 10 parts physical sunscreen, 10 parts chemical sunscreen, 0.5 parts photoactivated enzyme repair factor, 4 parts ginger flower root extract, 4 parts white water lily extract, 0.3 parts QUERCARE light-protecting agent, 3.083 parts photodamage repair agent, 3 parts glycerin, 1 part betaine, 2 parts tocopherol, 0.5 parts ferulic acid, 0.5 parts stearyl alcohol polyether-2, 0.5 parts stearyl alcohol polyether-21, 4 parts polymethyl silsesquioxane, 0.3 parts 1,2-pentanediol, and the balance being water.

[0109] A physical sunscreen agent was mixed with 18 parts by weight of water and sonicated at 200W for 20 min to obtain a physical sunscreen agent dispersion. A chemical sunscreen agent, tocopherol, ferulic acid, stearyl alcohol polyether-2, and stearyl alcohol polyether-21 were mixed and heated at 70°C for 10 min to obtain an oil phase. The remaining water, glycerin, betaine, polymethyl silsesquioxane, and 1,2-pentanediol were mixed to obtain an aqueous phase. The oil phase was added to the aqueous phase and homogenized at 10,000 rpm for 3 min. The physical sunscreen agent dispersion was then added and homogenized at 5,500 rpm for 1.5 min. Photoactivated enzyme repair factor, ginger flower root extract, white water lily extract, QUERCARE light-protecting agent, and photodamage repair agent were added. The mixture was stirred at 250 rpm for 18 min, the pH was adjusted to 6.5, and the mixture was degassed under vacuum and sterilized to obtain a cosmetic composition.

[0110] Comparative Example 1

[0111] The specific implementation method is the same as in Example 4, except that "8 parts of physical sunscreen and 12 parts of chemical sunscreen" are replaced with "20 parts of physical sunscreen".

[0112] Comparative Example 2

[0113] The specific implementation method is the same as that in Example 4, except that "8 parts of physical sunscreen and 12 parts of chemical sunscreen" are replaced with "20 parts of chemical sunscreen" and step (1) is deleted.

[0114] Comparative Example 3

[0115] The specific implementation method is the same as in Example 4, except that the physical sunscreen agent is replaced with nano titanium dioxide and step (1) is deleted.

[0116] Comparative Example 4

[0117] The specific implementation method is the same as in Example 4, except that the chemical sunscreen agent is composed of homosalate, avobenzone and octocrylene in a weight ratio of 3:2:4.

[0118] Comparative Example 5

[0119] The specific implementation method is the same as that in Example 4, except that the "60% ethanol solution by volume" in step (1) of preparing the photodamage repair agent is replaced with water.

[0120] Comparative Example 6

[0121] The specific implementation method is the same as in Example 4, except that in step (1) the preparation of the photodamage repair agent, Lactobacillus paracasei CICC 25261 is replaced with Lactobacillus helveticus CICC 22818, and Bifidobacterium adolescentis CICC 24573 is replaced with Bifidobacterium longum CICC 6207, while other conditions remain unchanged.

[0122] Comparative Example 7

[0123] The specific implementation method is the same as in Example 4, except that the photodamage repair agent is composed of chamomile extract, calendula extract and licorice extract in a weight ratio of 2:3:2.

[0124] Experimental Example 1

[0125] Sunscreen efficacy test

[0126] In accordance with the method for selecting subjects in section 4.2 of the "Cosmetic Safety Technical Specifications" for determining the sun protection index (SPF value) of sunscreen cosmetics, 100 subjects were selected and divided into 10 groups of 10 subjects each. There were no significant differences in age and skin condition among the groups.

[0127] The SPF and PFA values ​​of the cosmetic compositions in Examples 4-6 and Comparative Examples 1-7 were determined according to the determination methods of the Sun Protection Factor (SPF) and UVA (PFA) values ​​of sunscreen cosmetics in the "Cosmetic Safety Technical Specifications". The specific results are shown in Table 3.

[0128] Table 3. SPF and PFA values ​​of each cosmetic composition group

[0129] Group SPF value PFA value Example 4 58.7 17.6 Example 5 57.6 16.5 Example 6 58.3 17.2 Comparative Example 1 42.8 11.9 Comparative Example 2 41.1 11.4 Comparative Example 3 50.2 13.8 Comparative Example 4 49.4 13.7 Comparative Example 5 53.0 15.0 Comparative Example 6 52.5 14.3 Comparative Example 7 52.2 14.5

[0130] As shown in Table 3, the SPF and PFA values ​​of the cosmetic compositions in the examples are higher than those in the comparative examples. A comparison of the data from Example 4 and Comparative Examples 1-2 shows that the synergistic effect of physical and chemical sunscreens can cover more UV wavelengths, effectively blocking and absorbing UV rays, providing comprehensive UV protection, significantly improving SPF and PFA values, and giving the cosmetic composition a stronger sun protection effect. A comparison of the data from Example 4 and Comparative Example 3 shows that modifying nano-titanium dioxide can improve its stability and dispersibility, thereby enhancing the sun protection effect of the cosmetic composition. A comparison of the data from Example 4 and Comparative Example 4 shows that the synergistic effect of the three chemical sunscreens—bis-ethylhexyloxyphenol methoxyphenyl triazine, avobenzone, and octocrylene—reduces photodegradation and improves sun protection. A comparison of the data from Example 4 and Comparative Examples 5-7 shows that extraction with different solvents, fermentation by different microorganisms, and combinations of different ingredients can affect the SPF and PFA values ​​of the cosmetic composition.

[0131] Experimental Example 2

[0132] UV protection and repair effect against photodamage

[0133] After the subjects in Experiment 1 had their SPF and PFA values ​​measured, they applied the cosmetic compositions of Examples 4-6 and Comparative Examples 1-7 respectively. After one week of use, the UV protection and photodamage repair effects were evaluated. Subjects scored the compositions on a 10-point scale, from 1 (worst) to 10 (best), and the average value was taken. The specific results are shown in Table 4.

[0134] The method of using the cosmetic composition is as follows: After cleansing and basic skin care, take an amount of the cosmetic composition the size of a one-yuan coin (about 0.9g) and apply it to five areas: cheeks, forehead, nose tip, and chin with your fingertips. Massage evenly in a clockwise circular motion in the same direction until it forms a film.

[0135] Table 4. UV protection and photodamage repair scores of each cosmetic composition group

[0136] Group UV protection and photodamage repair rating Group UV protection and photodamage repair rating Example 4 9.5 Comparative Example 3 5.6 Example 5 9.0 Comparative Example 4 6.2 Example 6 9.2 Comparative Example 5 6.8 Comparative Example 1 5.4 Comparative Example 6 6.3 Comparative Example 2 5.0 Comparative Example 7 6.1

[0137] As shown in Table 4, the examples significantly improved the UV protection photodamage repair score compared to the comparative examples. A comparison of the data from Example 4 and Comparative Examples 1-2 shows that the synergistic combination of physical and chemical sunscreens significantly reduced UV photodamage, decreased sunburn and photoaging, thereby improving the photodamage repair effect. A comparison of the data from Example 4 and Comparative Examples 3-4 shows that modifying nano-titanium dioxide and adjusting the composition of the photodamage repair agent can improve the UV protection photodamage repair effect. A comparison of the data from Example 4 and Comparative Examples 5-7 shows that extraction with different solvents, fermentation by different microorganisms, and combinations of different ingredients can affect the UV protection photodamage repair effect of the cosmetic composition.

[0138] The above description is only a preferred embodiment of the present invention. It should be noted that for those skilled in the art, several improvements and modifications can be made without departing from the principle of the present invention, and these improvements and modifications should also be considered within the scope of protection of the present invention.

Claims

1. A cosmetic composition for broad-spectrum UV protection and cosmetic photoreversal and photodamage repair, characterized in that, The cosmetic composition includes QUERCARE (a light-protecting agent), photoactivated enzyme repair factor, ginger flower root extract, and white water lily extract in a weight ratio of (0.3-0.5):(0.3-0.5):(4-6):(2-4); the cosmetic composition also includes chemical sunscreens, physical sunscreens, and photodamage repair agents. The photodamage repair agent is composed of rockrose leaf extract, Ganoderma lucidum extract and hydrolyzed red algae extract; Physical sunscreens are composed of titanium dioxide and silica in a weight ratio of 40-45:55-60. The chemical sunscreen is composed of bis-ethylhexyloxyphenol methoxyphenyl triazine, avobenzone and octocrylene in a weight ratio of (2-4):(1-3):(3-5); Rockrose leaf extract was obtained by ethanol-microwave extraction; The hydrolyzed red algae extract was obtained by aerobic fermentation with Lactobacillus paracasei followed by anaerobic fermentation with Bifidobacterium adolescentis. Lactobacillus paracasei was obtained from the China Industrial Microbial Culture Collection Center, with accession number CICC 25261; Bifidobacterium adolescentis was obtained from the China Industrial Microbial Culture Collection Center, with accession number CICC 24573.

2. The cosmetic composition according to claim 1, characterized in that, This also includes acceptable excipients in cosmetics.

3. The use of a cosmetic composition according to any one of claims 1-2 in a sunscreen cosmetic.

4. The use of a cosmetic composition according to any one of claims 1-2 in a photodamage repair cosmetic.