Ir-titanate nanobiocatalyst and preparation method and application thereof

By using iridium-strontium titanate nanobiocatalyst (Ir-STO) to mimic enzyme activity under acidic and neutral conditions, the problem of imbalance and limited efficacy in the treatment of caries and periodontitis in existing technologies has been solved, achieving highly efficient antibacterial, anti-inflammatory and tissue repair effects.

CN121287744BActive Publication Date: 2026-04-14SICHUAN UNIV
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Patent Information

Application Number
CN202511874772.2
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2025-12-12
Publication Date
2026-04-14
Estimated Expiration
2045-12-12

AI Technical Summary

Technical Problem

Existing antibiotics for treating dental caries and periodontitis can easily disrupt the oral ecological balance, leading to the risk of drug resistance. Furthermore, they are difficult to effectively break the vicious cycle of bacterial destruction and inflammatory damage, resulting in limited clinical efficacy.

Method used

A strontium-iridium titanate nanobiocatalyst (Ir-STO) was developed. This catalyst exhibits pH responsiveness, with peroxidase-like activity killing cariogenic bacteria under acidic conditions, catalase-like activity inhibiting the growth of Porphyromonas gingivalis under neutral conditions, and generating singlet oxygen under NIR light to enhance its antibacterial effect while releasing strontium ions to promote tissue repair.

Benefits of technology

Ir-STO can effectively kill cariogenic bacteria and inhibit Porphyromonas gingivalis under acidic and neutral conditions, maintain oral flora balance, reduce oxidative stress, regulate immune system balance, and promote tissue repair, providing a new approach to comprehensive treatment of periodontitis.

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Abstract

The application belongs to the technical field of catalyst materials, and particularly relates to an iridium-strontium titanate nanobiocatalyst, a preparation method and application thereof. Specifically, the iridium-strontium titanate nanobiocatalyst comprises strontium titanate and iridium nanoclusters loaded on the strontium titanate. The application further provides a preparation method of the iridium-strontium titanate nanobiocatalyst, which comprises preparing an iridium-strontium titanate precursor through a hydrothermal ion exchange reaction of strontium titanate and soluble iridium salt, and then performing calcination treatment on the iridium-strontium titanate precursor to obtain the iridium-strontium titanate nanobiocatalyst. The iridium-strontium titanate nanobiocatalyst has pH-dependent peroxidase-like and catalase-like activities, and has a good application prospect in antibacterial, biofilm removal, and prevention or treatment of dental caries and periodontitis.
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