Microdialysis brain tissue monitoring electrode needle

Abstract

The application discloses a microdialysis brain tissue monitoring electrode needle, which comprises an electrode needle (10) and a microdialysis probe (20). The electrode needle is a needle body structure extending towards an extension direction, one side of the electrode needle is provided with a first connecting surface (11), and the side opposite to the first connecting surface of the electrode needle is a first working surface (12) provided with an electrode point (13); the microdialysis probe is a tubular structure extending towards an extension direction, a microdialysis catheter (23) is arranged in the microdialysis probe, one side of the microdialysis probe is provided with a second connecting surface (21), and the side opposite to the second connecting surface of the microdialysis probe is a second working surface (22); and along the extension direction, one end of the microdialysis probe is wrapped with a dialysis membrane (25). The device can integrate the electrode needle and the microdialysis probe into one body, realize synchronous collection of the electrophysiological signals and biochemical information of the same brain area, and make the data correlation more accurate.

Description

Technical Field

[0001] This application relates to a monitoring device that can be used for both monitoring brain tissue electrodes and brain tissue microdialysis, and more particularly to a microdialysis brain tissue monitoring electrode needle. Background Technology

[0002] In the diagnosis and treatment of epilepsy, intracranial electrode implantation is commonly used for preoperative evaluation of drug-resistant epilepsy. By recording brain electrical activity, it locates the lesion and allows for interventions such as electrical stimulation or electrothermal coagulation of the implanted brain region to treat seizures. However, the application of these electrodes is currently mainly limited to the acquisition of electrophysiological signals. To comprehensively assess the functional state of local neurons in epilepsy patients, intracranial microdialysis technology is also used clinically to monitor the dynamic changes of important substances such as neurotransmitters, drugs, and their metabolites in extracellular fluid in real time and continuously, thereby reflecting real-time changes in the brain's chemical environment. Furthermore, microdialysis probes can precisely deliver drugs to specific brain regions, enabling targeted epilepsy treatment.

[0003] In current clinical practice, the two procedures mentioned above are usually performed separately and sequentially. First, doctors implant intracranial electrodes to collect electroencephalogram (EEG) signals for electrophysiological monitoring. Then, microdialysis is used to obtain interstitial fluid from the brain tissue for biochemical monitoring, analyzing neurotransmitters and other chemical substances. However, this separate approach has limitations. Because electrophysiological and biochemical signals from the same site cannot be acquired simultaneously, subsequent data analysis may be biased. Furthermore, the distributed operation not only prolongs the surgery and monitoring time but also increases brain tissue damage due to multiple intracranial procedures. Additionally, traditional microdialysis probes, used separately, often have a small dialysis membrane area on the dialysis side to ensure sufficient rigidity and stability during implantation, resulting in low dialysis efficiency. Summary of the Invention

[0004] To address the aforementioned issues, this application discloses a microdialysis brain tissue monitoring electrode needle that integrates the electrode needle with a microdialysis probe, enabling simultaneous acquisition of electrophysiological signals and biochemical information from the same brain region. This results in more accurate data correlation, shorter surgical time, and minimizes brain tissue damage due to a single puncture operation. Furthermore, it increases the dialysis membrane area on the dialysis side of the microdialysis probe and utilizes a rigid electrode needle to drive the microdialysis probe into the human brain, significantly improving dialysis efficiency.

[0005] To achieve the above objectives, this application adopts the following technical solution:

[0006] This application provides a microdialysis brain tissue monitoring electrode needle, which includes an electrode needle and a microdialysis probe. The electrode needle is a needle body structure extending in one direction. One side of the electrode needle is provided with a first connecting surface, and the side opposite to the first connecting surface of the electrode needle is a first working surface, and an electrode point is provided on the first working surface. The microdialysis probe is a tubular structure extending in one direction. A microdialysis catheter is inserted inside the microdialysis probe. One side of the microdialysis probe is provided with a second connecting surface, and the side opposite to the second connecting surface of the microdialysis probe is a second working surface. Along the extension direction, one end of the microdialysis probe is wrapped with a dialysis membrane. The first connecting surface of the electrode needle can be connected with the second connecting surface of the microdialysis probe to form an integral structure.

[0007] The monitoring electrode needle and the microdialysis probe are integrated into a single structure via a connecting part. After implantation into the human brain, this structure can acquire electrophysiological signals through the electrode needle and biochemical signals from the same brain location through the microdialysis probe. This allows for precise correlation of the data analysis, improving the accuracy of disease diagnosis. Simultaneous acquisition of both types of information can also shorten the operation time. Acquiring two types of information in a single puncture can also minimize brain tissue damage and ensure safety during the operation. Furthermore, the design of using a rigid electrode needle to drive the microdialysis probe into the human brain avoids the situation where the dialysis membrane area is reduced due to the need to increase the rigidity of the microdialysis probe. In other words, this microdialysis brain tissue monitoring electrode needle can increase the dialysis membrane area and improve microdialysis efficiency.

[0008] In one illustrative embodiment of the microdialysis brain tissue monitoring electrode needle, one of the first and second connecting surfaces has a strip-shaped recess along its extension direction, and the other of the first and second connecting surfaces has a strip-shaped protrusion along its extension direction. The strip-shaped protrusion can be inserted into the strip-shaped recess along its extension direction, maintaining a close connection between the first connecting surface of the electrode needle and the second connecting surface of the microdialysis probe. This design makes the integration of the electrode needle and the microdialysis probe convenient and quick, and the integration is more robust. Furthermore, the two can be separated as needed, allowing for the use of the electrode needle independently, thus increasing flexibility during use.

[0009] In one illustrative embodiment of the microdialysis brain tissue monitoring electrode needle, the first connecting surface of the electrode needle can be bonded to the second connecting surface of the microdialysis probe.

[0010] In one illustrative embodiment of a microdialysis brain tissue monitoring electrode needle, along its extension direction, the electrode needle includes an insertion end, a first connecting surface disposed at the insertion end, and a microdialysis probe includes a dialysis end, with a second connecting surface disposed at the dialysis end. This method of providing connecting portions only at the insertion end of the electrode needle and the dialysis end of the microdialysis probe avoids causing greater damage to the human brain by having the first connecting surface as a whole when the electrode needle needs to be used alone.

[0011] In one illustrative embodiment of the microdialysis brain tissue monitoring electrode needle, the first working surface of the electrode needle is an arc surface with a central angle α, where 180°≤α≤270°. The second working surface of the microdialysis probe is also an arc surface with a central angle β, where 180°≤β≤270°. This design ensures a stable connection between the first connecting surface of the electrode needle and the second connecting surface of the microdialysis probe, preventing instability due to insufficient area of ​​the connecting surfaces.

[0012] In one illustrative embodiment of the microdialysis brain tissue monitoring electrode needle, the central angle α corresponding to the arc surface of the electrode needle is 180°, and the central angle β corresponding to the arc surface of the microdialysis probe is 180°. This design makes the microdialysis brain tissue monitoring electrode needle, which is composed of the electrode needle and the microdialysis probe, cylindrical, reducing its cross-sectional area when implanted into the human brain and minimizing damage to brain tissue.

[0013] In one illustrative embodiment of the microdialysis brain tissue monitoring electrode needle, multiple electrode points are disposed on the first working surface of the electrode needle, and the multiple electrode points are evenly arranged along the extension direction. This design enables the brain tissue monitoring electrode needle to monitor the electrophysiological signals of the human brain from all directions and provide feedback.

[0014] In one illustrative embodiment of the microdialysis brain tissue monitoring electrode needle, the electrode needle further includes a holding base that can be fitted onto the integrated structure of the electrode needle and the microdialysis probe. This design makes the microdialysis brain tissue monitoring electrode easy to hold, and the holding base makes the connection between the electrode needle and the microdialysis probe more secure.

[0015] In one illustrative embodiment of the microdialysis brain tissue monitoring electrode needle, the end of the microdialysis probe relative to the dialysis end is a connecting end, and a microdialysis catheter extends from the connecting end. The microdialysis brain tissue monitoring electrode needle also includes a sealing plug, which is detachably disposed on the microdialysis catheter extending from the connecting end, allowing the sealing plug to seal the microdialysis catheter. This design allows the microdialysis catheter to be sealed with the sealing plug when the microdialysis brain tissue monitoring electrode needle is not in use, thus preventing contamination or dust ingress.

[0016] In one illustrative embodiment of the microdialysis brain tissue monitoring electrode needle, the length of the microdialysis brain tissue monitoring electrode needle is set to 5cm to 10cm. This design allows the operator to use microdialysis brain tissue monitoring electrode needles of different lengths according to actual needs.

[0017] The following description, in a clear and easy-to-understand manner and with reference to the accompanying drawings, will further explain the above-mentioned characteristics, technical features, advantages, and implementation methods of the microdialysis brain tissue monitoring electrode needle. Attached Figure Description

[0018] Various other advantages and benefits will become apparent to those skilled in the art upon reading the following detailed description of preferred embodiments. The accompanying drawings are for illustrative purposes only and are not intended to limit the scope of this application. Furthermore, the same reference numerals denote the same parts throughout the drawings. In the drawings:

[0019] Figure 1 A schematic diagram illustrating a possible embodiment of a microdialysis brain tissue monitoring electrode needle.

[0020] Figure 2 A schematic diagram illustrating a possible embodiment of the first connecting surface of the electrode needle.

[0021] Figure 3 A schematic diagram illustrating a possible embodiment of the second connection surface of a microdialysis probe.

[0022] Figure 4 This is a schematic diagram illustrating one possible implementation of the electrode needle for monitoring brain tissue during microdialysis.

[0023] Figure 5 A schematic diagram showing the disassembled structure of an exemplary embodiment of a microdialysis brain tissue monitoring electrode needle.

[0024] Figure 6 A schematic diagram illustrating a possible embodiment of the strip-shaped recess and strip-shaped protrusion.

[0025] Figure 7 This is an enlarged view of the local structure of the microdialysis brain tissue monitoring electrode needle implanted in one end of the human brain.

[0026] Figure 8 A cross-sectional view illustrating a schematic embodiment of a microdialysis brain tissue monitoring electrode needle.

[0027] Figure 9 A cross-sectional view illustrating another schematic embodiment of the microdialysis brain tissue monitoring electrode needle.

[0028] Label Explanation

[0029] 10 electrode needles

[0030] 11 First connecting surface

[0031] 111 strip-shaped depressions

[0032] 12 First Working Face

[0033] 13 electrode points

[0034] 14 Insertion end

[0035] 20 microdialysis probes

[0036] 21 Second connecting surface

[0037] 211 strip bumps

[0038] 22 Second Working Face

[0039] 23 microdialysis catheters

[0040] 231 connector

[0041] 232 Fixing Part

[0042] 24 dialysis end

[0043] 25dialysis membrane

[0044] 30 Holding the base

[0045] 32 sealing plug

[0046] 60 monitoring areas

[0047] 70 metabolites Detailed Implementation

[0048] To provide a clearer understanding of the technical features, objectives, and effects of this application, specific embodiments of this application are now described with reference to the accompanying drawings. In the drawings, the same reference numerals indicate components with the same or similar structures but the same function.

[0049] In this document, “illustrative” means “serving as an example, illustration or description”, and any illustration or implementation described herein as “illustrative” should not be construed as a more preferred or advantageous technical solution.

[0050] Figure 1 The diagram shown is a schematic representation of one embodiment of the microdialysis brain tissue monitoring electrode needle. Figure 1As shown, the microdialysis brain tissue monitoring electrode needle includes an electrode needle 10 (the right-hand structure shown in the figure) and a microdialysis probe 20 (the left-hand structure shown in the figure). In practical applications, the electrode needle 10 of the microdialysis brain tissue monitoring electrode needle extends into a lead wire, which can be connected to an external electrode display (not shown in the figure) to display the electrophysiological signals of the brain tissue in real time. At the same time, the microdialysis catheter 23 of the microdialysis probe 20 is externally connected to a microdialysis pump (not shown in the figure), which can control the microdialysis probe 20 to achieve microdialysis operation.

[0051] The electrode needle 10 is a needle structure extending in a direction A. In practical applications, the end of the needle structure is arc-shaped along the extension direction, which can reduce damage to the human brain during implantation. Figure 2 It can be seen that a first connecting surface 11 is provided on one side of the electrode needle 10. The first connecting surface 11 can be a planar structure, such as... Figure 1 A first working surface 12 is provided on the side opposite to the first connecting surface 11 of the electrode needle 10. Electrode points 13 are provided on the first working surface 12. Those skilled in the art will understand that the first connecting surface 11 and the first working surface 12 together form the electrode needle 10 part of the microdialysis brain tissue monitoring electrode needle. The electrode points 13 on the first working surface 12 can acquire electrophysiological signals of the brain region and output them outward for subsequent data analysis. According to the actual needs, multiple electrode points 13 can be provided on the first working surface 12. The multiple electrode points 13 can be evenly arranged along the extension direction A, so as to acquire brain tissue electrophysiological signals from all directions.

[0052] like Figure 1 As shown, the microdialysis probe 20 is a tubular structure extending in a direction A, i.e., its interior is hollow. A microdialysis catheter 23 is inserted inside the microdialysis probe 20. In practical applications, the microdialysis catheter 23 is inserted at the center of the microdialysis probe 20. Therefore, a fixing part 232 can be provided at the end of the microdialysis probe 20 away from the extension direction A to fix the microdialysis probe 20 inside the microdialysis catheter 23. Combined with... Figure 3 It can be seen that a second connecting surface 21 is provided on one side of the microdialysis probe 20 along the extension direction A. The second connecting surface 21 can also be set as a planar structure with the same as the first connecting surface 11, such as... Figure 1 As shown, a second working surface 22 is provided on the side opposite to the second connecting surface 21 of the microdialysis probe 20. Along the extension direction A, one end of the microdialysis probe 20 is wrapped with a dialysis membrane 25. Those skilled in the art will understand that the second connecting surface 21 and the second working surface 22 together form the microdialysis probe 20 part of the microdialysis brain tissue monitoring electrode needle, and brain tissue material can enter the microdialysis probe 20 through the dialysis membrane 25.

[0053] Combination Figure 1 , Figure 2 , Figure 3 It can be seen that the first connecting surface 11 of the electrode needle 10 can be connected to the second connecting surface 21 of the microdialysis probe 20 so that the electrode needle 10 and the microdialysis probe 20 form an integral structure, that is, the electrode needle 10 is on one side of the microdialysis brain tissue monitoring electrode needle along the extension direction A, and the microdialysis probe 20 is on the other side.

[0054] Figure 4 This demonstrates the working process of the microdialysis brain tissue monitoring electrode needle after implantation in the human brain, such as... Figure 4 As shown, when the microdialysis brain tissue monitoring electrode needle is inserted into a monitoring area 60 of the human brain tissue, the electrode point 13 on the electrode needle 10 can acquire the electrophysiological signal of the monitoring area 60 and output the signal outward through the wire, thereby displaying the signal in real time on the external electrode display. At the same time, the external microdialysis pump can apply a certain power and release microdialysis fluid into the monitoring area 60 through the microdialysis catheter 23. The microdialysis fluid circulates in the direction indicated by the arrow in the microdialysis catheter 23 in the figure, thereby driving the metabolic products 70 that have entered the microdialysis probe 20 through the dialysis membrane 25 to be recovered outside the human body for subsequent biochemical information monitoring. By combining the electrode needle 10 and the microdialysis probe 20 into an integrated structure, electrophysiological signals and biochemical signals can be acquired simultaneously in the same monitoring area 60 in a single puncture operation. The data monitored by the two are accurately correlated, which helps to improve the accuracy of disease diagnosis. Furthermore, a single puncture can not only shorten the operation time but also minimize brain tissue damage, ensuring the patient's safety during the operation. At the same time, the use of a rigid electrode needle 10 to drive the microdialysis probe 20 into the human brain avoids the situation where the dialysis membrane area is reduced due to the consideration of increasing the rigidity of the probe. That is, the design of the microdialysis brain tissue monitoring electrode needle can increase the dialysis membrane area and improve the microdialysis efficiency, so that the end of the microdialysis probe implanted into the human brain can be fully wrapped with the dialysis membrane 25.

[0055] In order to enable the electrode needle 10 and the microdialysis probe 20 to be tightly connected, in one embodiment, the first connecting surface 11 of the electrode needle 10 can be bonded to the second connecting surface of the microdialysis probe 20, so that the two form an integral structure.

[0056] In another embodiment, one of the first connecting surface 11 of the electrode needle 10 and the second connecting surface 21 of the microdialysis probe 20 is provided with a strip-shaped recess 111 along the extending direction A, and the other of the first connecting surface 11 of the electrode needle 10 and the second connecting surface 21 of the microdialysis probe 20 is provided with a strip-shaped protrusion 211 along the extending direction A. That is, Figure 5 As shown, it can be combined with Figure 2 and Figure 3The first connecting surface 11 of the electrode needle 10 can be provided with a strip-shaped recess 111, which extends along the extension direction A. The second connecting surface 21 of the microdialysis probe 20 can be provided with a strip-shaped protrusion 211, which also extends along the extension direction A. The strip-shaped protrusion 211 can be inserted into the strip-shaped recess 111 along the extension direction A, keeping the first connecting surface 11 of the electrode needle 10 and the second connecting surface 21 of the microdialysis probe 20 in close contact. This insertion method also allows the two to be separated according to actual needs, so that the electrode needle can be used alone. The separation method is simple and quick.

[0057] Among them, such as Figure 6 As shown, Figure 6 The left side is the first connecting surface 11 of the electrode needle 10, and the right side is the second connecting surface 21 of the microdialysis probe 20. It can be seen that the strip-shaped recess 111 of the first connecting surface 11 is configured as an inverted Y-shaped structure, narrow at the top and wide at the bottom, at the insertion entrance of the strip-shaped protrusion 211 of the second connecting surface 21. This allows the inclined surface of the inverted Y-shaped opening to guide the strip-shaped protrusion 211 to quickly insert when it is inserted into the strip-shaped recess 111, avoiding misalignment and inaccurate insertion. Of course, those skilled in the art will understand that the first connecting surface 11 can be a strip-shaped recess 111, the second connecting surface can be a strip-shaped protrusion 211, and the first connecting surface 11 and the second connecting surface 21 can be any structure capable of connecting the electrode needle 10 and the microdialysis probe 20.

[0058] To simplify the integration of the electrode needle 10 with the microdialysis probe 20, such as Figure 7 As shown, along the extension direction A, the electrode needle 10 includes an insertion end 14 and a first connecting surface 11 disposed at the insertion end 14. The microdialysis probe 20 includes a dialysis end 24 and a second connecting surface 21 disposed at the dialysis end 24. This method of providing a connecting part only at the insertion end 14 of the electrode needle 10 and the dialysis end 24 of the microdialysis probe 20 can also prevent greater damage to the human brain when the electrode needle 10 is implanted in the human brain when the two are separated and the electrode needle is used alone, because the first connecting surface 11 is integrally connected along the extension direction A.

[0059] In practical product applications, the first working surface 12 of the electrode needle 10 is an arc surface, and the central angle corresponding to the arc surface is α, and 180°≤α≤270°. The second working surface 22 of the microdialysis probe 20 is an arc surface, and the central angle corresponding to its arc surface is β, and 180°≤β≤270°. Those skilled in the art should understand that the central angle α corresponding to the arc surface of the electrode needle 10 should be the same as the central angle β corresponding to the arc surface of the microdialysis probe 20.

[0060] Figure 8 A cross-sectional view illustrating a schematic embodiment of a microdialysis brain tissue monitoring electrode needle. (See diagram below.) Figure 8As shown, the central angle α corresponding to the arc surface of the electrode needle 10 is 270°, and the central angle β corresponding to the arc surface of the microdialysis probe is the same. The electrode needle 10 and the microdialysis probe 20 are combined into a single structure.

[0061] Depending on the actual situation, such as Figure 9 As shown, the central angle α corresponding to the arc surface of the electrode needle 10 can also be 180°, and the central angle β corresponding to the arc surface of the microdialysis probe is still the same. That is, the electrode needle 10 can be combined with the microdialysis probe 20 to form a cylinder. This structure makes the connection area between the first connecting surface 11 and the second connecting surface 21 larger, the connection more stable, and the cross-sectional area of ​​the cylinder smaller, resulting in less damage to brain tissue when implanted into the human brain.

[0062] In practical product applications, to facilitate the holding of the microdialysis brain tissue monitoring electrode needle, a holding base 30 is also provided, such as... Figure 1 As shown, after the electrode needle 10 and the microdialysis probe 20 are combined, the holding base 30 can be fitted onto the integrated structure formed by the electrode needle 10 and the microdialysis probe 20, which avoids the electrode needle 10 and the microdialysis probe 20 from separating during operation and reduces surgical risks.

[0063] like Figure 1 As shown, the end of the microdialysis probe 20 relative to the dialysis end 24 is a connection end 231. The microdialysis catheter 23 extends out of the connection end 231. The microdialysis brain tissue monitoring electrode needle also includes a sealing plug 32. The sealing plug 32 is detachably disposed on the microdialysis catheter 23 extending out of the connection end 231, so that the sealing plug 32 can seal the microdialysis catheter 23. During the use of the microdialysis brain tissue monitoring electrode needle, the connection end 231 of the microdialysis catheter 23 is connected to the microdialysis pump. After use, in order to prevent contamination or dust from entering the microdialysis catheter 23 extending out of the connection end 231 of the microdialysis probe 20, the sealing plug 32 can be connected to the microdialysis catheter 23. If continued use is desired, the sealing plug 32 can be removed.

[0064] Depending on the actual needs, the length of the microdialysis brain tissue monitoring electrode needle can be set from 5cm to 10cm, which can monitor different parts of the human brain and avoid inaccurate monitoring caused by insufficient length of the microdialysis brain tissue monitoring electrode needle.

[0065] To keep the drawings concise, only the parts relevant to this application are shown schematically in each drawing, and they do not represent the actual structure of the product. In addition, to make the drawings concise and easy to understand, in some drawings, only one of the components with the same structure or function is shown schematically, or only one of them is labeled.

[0066] It should be understood that although this specification describes various embodiments, not every embodiment contains only one independent technical solution. This way of describing the specification is only for clarity. Those skilled in the art should regard the specification as a whole. The technical solutions in each embodiment can also be appropriately combined to form other embodiments that can be understood by those skilled in the art.

[0067] The detailed descriptions listed above are merely specific descriptions of feasible embodiments of this application and are not intended to limit the scope of protection of this application. All equivalent implementations or modifications made without departing from the spirit of the art of this application, such as combinations, divisions or repetitions of features, should be included within the scope of protection of this application.

Claims

1. A microdialysis brain tissue monitoring electrode needle, characterized in that, It includes: Electrode needle (10), the electrode needle (10) is a needle body structure extending in an extension direction, a first connecting surface (11) is provided on one side of the electrode needle (10), and a first working surface (12) is provided on the side opposite to the first connecting surface (11) of the electrode needle (10), and an electrode point (13) is provided on the first working surface (12). A microdialysis probe (20) is a tubular structure extending in a certain direction. A microdialysis catheter (23) is inserted inside the microdialysis probe (20). A second connecting surface (21) is provided on one side of the microdialysis probe (20), and a second working surface (22) is provided on the side opposite to the second connecting surface (21) of the microdialysis probe (20). Along the extension direction, one end of the microdialysis probe (20) is wrapped with a dialysis membrane (25). The first connecting surface (11) of the electrode needle (10) can be connected to the second connecting surface (21) of the microdialysis probe (20) to form an integral structure.

2. The microdialysis brain tissue monitoring electrode needle according to claim 1, characterized in that, One of the first connecting surface (11) and the second connecting surface (21) is provided with a strip-shaped recess (111) along the extending direction. The other of the first connecting surface (11) and the second connecting surface (21) is provided with a strip-shaped protrusion (211) along the extending direction. The strip-shaped protrusion (211) can be inserted into the strip-shaped recess (111) along the extension direction, and keep the first connecting surface (11) of the electrode needle (10) and the second connecting surface (21) of the microdialysis probe (20) in close contact.

3. The microdialysis brain tissue monitoring electrode needle according to claim 1, characterized in that, The first connecting surface (11) of the electrode needle (10) can be bonded to the second connecting surface (21) of the microdialysis probe (20).

4. The microdialysis brain tissue monitoring electrode needle according to claim 1, characterized in that, Along the said extension direction, The electrode needle (10) includes an insertion end (14), and the first connecting surface (11) is disposed on the insertion end (14). The microdialysis probe (20) includes a dialysis end (24), and the second connecting surface (21) is disposed on the dialysis end (24).

5. The microdialysis brain tissue monitoring electrode needle according to claim 1, characterized in that, The first working surface (12) of the electrode needle (10) is an arc surface, and the central angle corresponding to the arc surface is α, 180°≤α≤270°; The second working surface (22) of the microdialysis probe (20) is an arc surface, and the central angle corresponding to the arc surface is β, 180°≤β≤270°.

6. The microdialysis brain tissue monitoring electrode needle according to claim 5, characterized in that, The central angle α of the arc surface of the electrode needle (10) is 180°, and the central angle β of the arc surface of the microdialysis probe (20) is 180°.

7. The microdialysis brain tissue monitoring electrode needle according to claim 1, characterized in that, The electrode needle (10) has a plurality of electrode points (13) on its first working surface (12), and the plurality of electrode points (13) are evenly arranged along the extension direction.

8. The microdialysis brain tissue monitoring electrode needle according to claim 1, characterized in that, The microdialysis brain tissue monitoring electrode needle also includes a holding base (30), which can be fitted onto the integral structure formed by the electrode needle (10) and the microdialysis probe (20).

9. The microdialysis brain tissue monitoring electrode needle according to claim 4, characterized in that, The end of the microdialysis probe (20) relative to the dialysis end (24) is a connection end (231), and the microdialysis catheter (23) extends out of the connection end (231). The microdialysis brain tissue monitoring electrode needle also includes a sealing plug (32), which is detachably disposed on the microdialysis catheter (23) extending from the connecting end (231), so that the sealing plug (32) can seal the microdialysis catheter (23).

10. The microdialysis brain tissue monitoring electrode needle according to claim 1, characterized in that, The length of the microdialysis brain tissue monitoring electrode needle is set to 5cm to 10cm.

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