Plant composition for treating acute and chronic rhinitis and preparation method thereof

Abstract

The invention relates to a plant composition for treating acute and chronic rhinitis and a preparation method thereof. The plant composition comprises the following raw material components in parts by weight: 7.5-20 parts of blumea oil; 3.5-6 parts of sesame oil; 0.8 to 2.5 parts of licoflavone A; 1.5-4 parts of a radix angelicae dahuricae extract; 2-6 parts of a cocklebur fruit extract; 3-9 parts of Roventura leaf essential oil; 8-15 parts of peppermint essential oil; and 12-24 parts of tea tree essential oil. In the formula of the composition disclosed by the invention, licoflavone A has the effects of resisting oxidation, resisting inflammation, regulating hormone and the like, and can be used for scavenging free radicals, effectively eliminating adverse effects of the free radicals on the nasal cavity and prolonging the acting effect and the shelf life. The folium artemisiae argyi contains volatile oil (such as eucalyptol, camphor and the like) and flavonoid compounds, and has the effects of inhibiting bacteria, relieving inflammation and alkalizing mucus; artemisia argyi can warm channels, dispel cold and relieve nasal obstruction, running nose and other symptoms caused by wind-cold or allergy.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine. In particular, it relates to a plant composition for treating acute and chronic rhinitis and its preparation method. Background Technology

[0002] Rhinitis is an inflammatory disease affecting the nasal mucosa. Its etiology is complex, but it is generally believed to result from inflammatory changes in the nasal mucosa caused by viruses, bacteria, allergens, various physical and chemical factors, and certain systemic diseases. The main pathological changes in rhinitis include congestion, swelling, exudation, hyperplasia, atrophy, or necrosis of the nasal mucosa.

[0003] Currently, the main treatments for rhinitis fall into three categories: medication, acupuncture, and surgery. Medication includes both traditional Chinese medicine and Western medicine. Commonly used Western medicines include antihistamines, corticosteroids, and leukotriene inhibitors. These drugs have certain toxic side effects and cannot completely cure the condition; repeated use can easily lead to drug resistance. Traditional Chinese medicine, on the other hand, can differentiate syndromes and treat accordingly, with few or no side effects. In recent years, the application of traditional Chinese medicine in treating allergic rhinitis has become widespread. For example, patents CN117771296A discloses a composition for preventing allergic rhinitis; CN113577139A discloses the application of a plant composition in the preparation of a rhinitis treatment drug; CN108042611A discloses a pure plant composition for treating rhinitis and its preparation method; and CN108014175A discloses a plant composition for relieving rhinitis symptoms. These solutions have achieved some effectiveness, but it is necessary to develop more rhinitis treatment drugs. A common problem with these solutions is the difficulty in achieving long-term drug delivery. Summary of the Invention

[0004] The technical problem to be solved by the present invention is to provide a plant composition for treating acute and chronic rhinitis and its preparation method, in order to address the shortcomings of the prior art.

[0005] To solve the above-mentioned technical problems, the technical solution adopted by the present invention is as follows: In its first aspect, the present invention provides a plant composition for treating acute and chronic rhinitis, comprising the following raw material components in parts by weight: Artemisia argyi oil 7.5-20 parts; 3.5-6 parts sesame oil; Licorice isoflavone A 0.8-2.5 parts; Angelica dahurica extract 1.5-4 parts; 2-6 parts of Xanthium sibiricum extract; Ravensard leaf essential oil 3-9 parts; 8-15 parts peppermint essential oil; 12-24 parts tea tree oil.

[0006] Preferably, the Angelica dahurica extract is prepared by the following method: Angelica dahurica is ball-milled to below 300-800 mesh, the obtained Angelica dahurica powder is added to ethanol, ultrasonically dispersed for 15-60 min, then stirred at 50-80℃ and 200-1000 rpm for 2 h, centrifuged, the supernatant is distilled under reduced pressure and vacuum dried to obtain Angelica dahurica extract; In this context, the volume of ethanol is 20-50 times the mass of Angelica dahurica powder, measured in mL and g respectively.

[0007] Preferably, the Angelica dahurica extract is prepared by the following method: Angelica dahurica is ball-milled to below 600 mesh, the obtained Angelica dahurica powder is added to ethanol, ultrasonically dispersed for 30 min, then stirred at 70℃ and 500 rpm for 2 h, centrifuged, the supernatant is distilled under reduced pressure and vacuum dried to obtain Angelica dahurica extract; In this context, the volume of ethanol is 30 times the mass of Angelica dahurica powder, measured in mL and g respectively.

[0008] Preferably, the Xanthium sibiricum extract is prepared by the following method: Xanthium sibiricum is ball-milled to below 400-700 mesh, the resulting Angelica dahurica powder is added to ethanol, ultrasonically dispersed for 15-60 min, then stirred at 40-60℃ and 500-1000 rpm for 1.5-6 h, centrifuged, the supernatant is distilled under reduced pressure and vacuum dried to obtain Angelica dahurica extract; In terms of volume (mL) and mass (g), the volume of ethanol is 25-70 times the mass of Angelica dahurica powder.

[0009] Preferably, the Xanthium sibiricum extract is prepared by the following method: Xanthium sibiricum is ball-milled to below 600 mesh, the resulting Angelica dahurica powder is added to ethanol, ultrasonically dispersed for 30 min, then stirred at 50℃ and 700 rpm for 3 h, centrifuged, the supernatant is distilled under reduced pressure and vacuum dried to obtain Angelica dahurica extract; In this context, the volume of ethanol is 35 times the mass of Angelica dahurica powder, measured in mL and g respectively.

[0010] A second aspect of the invention provides the use of the plant composition described above in the preparation of a medicament for treating acute and chronic rhinitis.

[0011] In a third aspect, the present invention provides an preparation for treating acute and chronic rhinitis, comprising the plant composition described above, wherein the preparation is a patch, spray, liniment, ointment, powder or film.

[0012] A fourth aspect of the present invention provides a patch for treating acute and chronic rhinitis, comprising a substrate and a gel disposed on the substrate, the gel comprising the plant composition described above.

[0013] Preferably, the patch for treating acute and chronic rhinitis is prepared by the following method: S1. Preparation of mesoporous silica-calcium carbonate composite particles: Take 1.1-4.4g of calcium chloride and 0.75-3g of hexadecyltrimethylammonium bromide and add them to a mixture of 50-300mL of deionized water and isopropanol in a volume ratio of 2:1. Stir for 5-30min, then add 2.1-8.4mL of tetraethyl orthosilicate and stir for 30-90min. Add 10-20wt% ammonia water to the resulting mixture to adjust the pH to 10-11. Add 7.5-30g of 10-30wt% deionized sodium carbonate solution while stirring. Stir at 40-60℃ for 1-4h, let stand at room temperature for 2-8h, centrifuge, wash with deionized water, vacuum dry, and then calcine at 450-550℃ for 1.5-6h to obtain mesoporous silica-calcium carbonate composite particles. S2. Loading plant compositions onto mesoporous silica-calcium carbonate composite particles yields drug-loaded active particles: S2-1. According to the proportion of the plant composition, mix the artemisia oil, sesame oil, glycyrrhizin A, angelica extract, cocklebur extract, ravensardine leaf essential oil, peppermint essential oil and tea tree essential oil, and stir for 1 hour to obtain the plant composition. S2-2. Take 0.5-2g of mesoporous silica-calcium carbonate composite particles and add them to 10-40mL of deionized water. Disperse them by ultrasonication for 0.5-2h to obtain a carrier dispersion. S2-3. Take 1-4g of the prepared plant composition for treating acute and chronic rhinitis and add it to a mixture of 20-80mL of ethanol and deionized water in a volume ratio of 3:1. Stir at 1000-2000rpm for 30-90min to obtain the composition solution. S2-4. Add the carrier dispersion to the composition solution under stirring at 500-1200 rpm, keep stirring for 1-4 h, shake on a shaker at room temperature for 4-12 h, filter, and vacuum dry to obtain drug-loaded active particles. S3. Preparation of the dressing: S3-1. Add 5-20g of drug-loaded active particles and 15-60g of ethanol to 35-140g of deionized water and sonicate for 0.5-2h. Then add 4-16g of hydroxyethyl cellulose and 2.5-10g of methyl cellulose, stir for 30-90min, and then add 1.75-7g of sodium hyaluronate. Stir and react for 2-8h, and let stand at room temperature for 3-12h to obtain a gel. S3-2. Apply the obtained gel to the surface of medical gauze, controlling the wet coating amount to be 0.5-4 g / cm³. 2 Vacuum-dry at 40-65℃ for 4-12 hours to obtain the patch for treating acute and chronic rhinitis.

[0014] Preferably, the patch for treating acute and chronic rhinitis is prepared by the following method: S1. Preparation of mesoporous silica-calcium carbonate composite particles: Take 2.2g of calcium chloride and 1.5g of hexadecyltrimethylammonium bromide and add them to a mixture of 150mL of deionized water and isopropanol in a volume ratio of 2:1. Stir for 15min, then add 4.2mL of tetraethyl orthosilicate and stir for 60min. Add 15wt% ammonia water to the resulting mixture to adjust the pH to 11. Add 15g of 20wt% sodium carbonate deionized water dropwise while stirring. Stir at 50℃ for 2h, let stand at room temperature for 4h, centrifuge, wash with deionized water, vacuum dry at 100℃ for 6h, and then calcine at 500℃ for 3h to obtain mesoporous silica-calcium carbonate composite particles. S2. Loading plant compositions onto mesoporous silica-calcium carbonate composite particles yields drug-loaded active particles: S2-1. According to the proportion of the plant composition, mix the artemisia oil, sesame oil, glycyrrhizin A, angelica extract, cocklebur extract, ravensardine leaf essential oil, peppermint essential oil and tea tree essential oil, and stir for 1 hour to obtain the plant composition. S2-2. Take 1g of mesoporous silica-calcium carbonate composite particles and add them to 20mL of deionized water. Disperse them by ultrasonication for 1h to obtain a carrier dispersion. S2-3. Take 2g of the prepared plant composition for treating acute and chronic rhinitis and add it to a mixture of 40mL of ethanol and deionized water in a volume ratio of 3:1. Stir at 1500rpm for 45min to obtain the composition solution. S2-4. The carrier dispersion was added to the composition solution under stirring at 1000 rpm, and stirring was maintained for 2 hours. The mixture was then shaken on a shaker at room temperature for 8 hours, filtered, and vacuum dried at 50°C for 12 hours to obtain drug-loaded active particles. S3. Preparation of the dressing: S3-1. Add 10g of drug-loaded active particles and 30g of ethanol to 70g of deionized water and sonicate for 1h. Then add 8g of hydroxyethyl cellulose and 5g of methyl cellulose, stir for 45min, and then add 3.5g of sodium hyaluronate. Stir and react for 4h, and let stand at room temperature for 6h to obtain a gel. S3-2. Apply the obtained gel to the surface of medical gauze, controlling the wet coating amount to 1 g / cm³. 2 The patch for treating acute and chronic rhinitis was obtained by vacuum drying at 60°C for 8 hours.

[0015] The beneficial effects of this invention are: This invention provides a plant composition for treating acute and chronic rhinitis, as well as a patch based on this plant composition. In the composition formulation of this invention: glycyrrhizin isoflavone A has antioxidant, anti-inflammatory, and hormone-regulating effects, can scavenge free radicals, effectively eliminate the adverse effects of free radicals on the nasal cavity, and prolong the effect and shelf life. Artemisia argyi contains volatile oils (such as eucalyptol and camphor) and flavonoids, which have antibacterial, anti-inflammatory, and mucus-alkalizing effects; Artemisia argyi can warm the meridians and dispel cold, relieving symptoms such as nasal congestion and runny nose caused by wind-cold or allergies. Sesame oil contains vitamin E and fatty acids, which have lubricating and moisturizing effects, lubricating the nasal mucosa, reducing dryness and crusting, and having a certain relieving effect on atrophic rhinitis or dry rhinitis. Angelica dahurica extract can dispel wind and release exterior pathogens, dispel cold and dry dampness, and relieve symptoms such as nasal congestion and runny nose. The terpinene contained in Xanthium sibiricum extract and the terpinene contained in Cypress extract have anti-inflammatory effects. The caryophyllene in ravensardine leaf essential oil has antihistamine effects, inhibiting allergic reactions, reducing congestion and edema of mucous membranes, and decreasing nasal secretions. Peppermint essential oil is a pungent, cooling, diaphoretic, and antipyretic, with cough-suppressing, asthma-relieving, heat-clearing, detoxifying, wind-dispelling, and pain-relieving effects, and can alleviate nasal congestion and runny nose. Tea tree essential oil has antibacterial, anti-inflammatory, pore-tightening, and therapeutic effects on colds, rhinitis, and asthma, and can enhance therapeutic efficacy.

[0016] This invention also provides a patch for treating acute and chronic rhinitis. In this patch, a plant composition is loaded onto mesoporous silica-calcium carbonate composite particles to obtain drug-loaded active particles with sustained-release properties. These drug-loaded active particles are then used as the active component of a gel to prepare the patch. The drug-loaded active particles enable the continuous and stable release of the plant composition, allowing the plant composition to fully and efficiently exert its therapeutic effect, thereby prolonging the patch's duration of action and improving its overall efficacy. In the mesoporous silica-calcium carbonate composite particles of this invention, the doping with silica improves the stability of the calcium carbonate nanoparticles, reduces pore structure collapse, and increases porosity and pore uniformity, thereby increasing the loading capacity and improving the ability to stably release the composition. Attached Figure Description

[0017] Figure 1 The results show the drug loading of the drug-loaded active particles in Example 1, Comparative Example 1, and Comparative Example 2 at different oscillation times. Figure 2 The results are the sustained-release performance test results of the drug-loaded active particles prepared in Example 1, Comparative Example 1, and Comparative Example 2. Figure 3 The average score for each subject before and after treatment; Figure 4 The percentage of subjects whose scores decreased after treatment. Detailed Implementation

[0018] The following specific embodiments illustrate the implementation of the present invention. Those skilled in the art can easily understand other advantages and effects of the present invention from the content disclosed in this specification. Obviously, the described embodiments are only some, not all, of the embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0019] Unless otherwise specified, the experimental methods used in the following examples are conventional methods. Unless otherwise specified, the materials and reagents used in the following examples are commercially available. For examples where specific conditions are not specified, conventional conditions or conditions recommended by the manufacturer are followed. For reagents or instruments whose manufacturers are not specified, they are all commercially available products.

[0020] This invention provides a plant-based composition for treating acute and chronic rhinitis, comprising the following raw material components in parts by weight: Artemisia argyi oil 7.5-20 parts; 3.5-6 parts sesame oil; Licorice isoflavone A 0.8-2.5 parts; Angelica dahurica extract 1.5-4 parts; 2-6 parts of Xanthium sibiricum extract; Ravensard leaf essential oil 3-9 parts; 8-15 parts peppermint essential oil; 12-24 parts tea tree oil.

[0021] In a preferred embodiment, Angelica dahurica extract is prepared by the following method: Angelica dahurica is ball-milled to below 300-800 mesh, the obtained Angelica dahurica powder is added to ethanol, ultrasonically dispersed for 15-60 min, then stirred at 50-80℃ and 200-1000 rpm for 2 h, centrifuged, the supernatant is distilled under reduced pressure and vacuum dried to obtain Angelica dahurica extract; In this context, the volume of ethanol is 20-50 times the mass of Angelica dahurica powder, measured in mL and g respectively.

[0022] In a preferred embodiment, the Xanthium sibiricum extract was prepared by the following method: Xanthium sibiricum was ball-milled to below 400-700 mesh, the resulting Angelica dahurica powder was added to ethanol, ultrasonically dispersed for 15-60 min, and then stirred at 40-60℃ and 500-1000 rpm for 1.5-6 h. After centrifugation, the supernatant was distilled under reduced pressure and dried under vacuum to obtain the Angelica dahurica extract. In terms of volume (mL) and mass (g), the volume of ethanol is 25-70 times the mass of Angelica dahurica powder.

[0023] The present invention also provides the use of the above-mentioned plant composition in the preparation of a medicament for treating acute and chronic rhinitis.

[0024] The present invention also provides an preparation for treating acute and chronic rhinitis, comprising the above-mentioned plant composition, wherein the preparation is a patch, spray, liniment, ointment, powder or film.

[0025] The present invention also provides a patch for treating acute and chronic rhinitis, comprising a substrate and a gel disposed on the substrate, the gel comprising the above-described plant composition.

[0026] In a preferred embodiment, the patch for treating acute and chronic rhinitis is prepared by the following method: S1. Preparation of mesoporous silica-calcium carbonate composite particles: Take 1.1-4.4g of calcium chloride and 0.75-3g of hexadecyltrimethylammonium bromide and add them to a mixture of 50-300mL of deionized water and isopropanol in a volume ratio of 2:1. Stir for 5-30min, then add 2.1-8.4mL of tetraethyl orthosilicate and stir for 30-90min. Add 10-20wt% ammonia water to the resulting mixture to adjust the pH to 10-11. Add 7.5-30g of 10-30wt% deionized sodium carbonate solution while stirring. Stir at 40-60℃ for 1-4h, let stand at room temperature for 2-8h, centrifuge, wash with deionized water, vacuum dry, and then calcine at 450-550℃ for 1.5-6h to obtain mesoporous silica-calcium carbonate composite particles. S2. Loading plant compositions onto mesoporous silica-calcium carbonate composite particles yields drug-loaded active particles: S2-1. According to the proportion of the plant composition, mix the artemisia oil, sesame oil, glycyrrhizin A, angelica extract, cocklebur extract, ravensardine essential oil, peppermint essential oil and tea tree essential oil, stir for 1 hour to obtain the plant composition. S2-2. Take 0.5-2g of mesoporous silica-calcium carbonate composite particles and add them to 10-40mL of deionized water. Disperse them by ultrasonication for 0.5-2h to obtain a carrier dispersion. S2-3. Take 1-4g of the prepared plant composition for treating acute and chronic rhinitis and add it to a mixture of 20-80mL of ethanol and deionized water in a volume ratio of 3:1. Stir at 1000-2000rpm for 30-90min to obtain the composition solution. S2-4. Add the carrier dispersion to the composition solution under stirring at 500-1200 rpm, keep stirring for 1-4 h, shake on a shaker at room temperature for 4-12 h, filter, and vacuum dry to obtain drug-loaded active particles. S3. Preparation of the dressing: S3-1. Add 5-20g of drug-loaded active particles and 15-60g of ethanol to 35-140g of deionized water and sonicate for 0.5-2h. Then add 4-16g of hydroxyethyl cellulose and 2.5-10g of methyl cellulose, stir for 30-90min, and then add 1.75-7g of sodium hyaluronate. Stir and react for 2-8h, and let stand at room temperature for 3-12h to obtain a gel. S3-2. Apply the obtained gel to the surface of medical gauze, controlling the wet coating amount to be 0.5-4 g / cm³. 2 Vacuum-dry at 40-65℃ for 4-12 hours to obtain a patch for treating acute and chronic rhinitis.

[0027] In the composition formulation of the present invention: Licorice isoflavone A has antioxidant, anti-inflammatory, and hormone-regulating effects. It can scavenge free radicals, effectively eliminate the adverse effects of free radicals on the nasal cavity, and prolong the effect and shelf life.

[0028] Artemisia argyi contains volatile oils (such as eucalyptol and camphor) and flavonoids, which can inhibit bacteria, reduce inflammation, and alkalize mucus. Artemisia argyi can warm the meridians and dispel cold, relieving symptoms such as nasal congestion and runny nose caused by wind-cold or allergies.

[0029] Sesame oil contains vitamin E and fatty acids, and has lubricating and moisturizing effects. It can lubricate the nasal mucosa, reduce dryness and crusting, and has a certain relieving effect on atrophic rhinitis or dry rhinitis.

[0030] Angelica dahurica extract can dispel wind and release the exterior, dispel cold and dry dampness, and relieve symptoms such as nasal congestion and runny nose.

[0031] The terpinene contained in Xanthium sibiricum extract and the terpinene contained in Cypress extract have anti-inflammatory effects.

[0032] The caryophyllene contained in ravensa leaf essential oil has antihistamine effects, which can inhibit allergic reactions, reduce congestion and edema of mucous membrane tissues, and reduce nasal secretions.

[0033] Peppermint essential oil is a pungent and cooling diaphoretic and antipyretic. It has the effects of relieving cough and asthma, clearing heat and detoxifying, dispelling wind and relieving pain, and can relieve nasal congestion and runny nose.

[0034] Tea tree oil has antibacterial and anti-inflammatory properties, can tighten pores, and can treat colds, rhinitis, and asthma, enhancing the therapeutic effect.

[0035] Furthermore, the present invention also provides a patch for treating acute and chronic rhinitis. In this patch, a plant composition is loaded with mesoporous silica-calcium carbonate composite particles to obtain drug-loaded active particles with sustained-release properties. The drug-loaded active particles are then used as the active component of the gel to prepare the patch. The drug-loaded active particles can continuously and stably release the plant composition, allowing the plant composition to fully and efficiently exert its therapeutic effect, thereby prolonging the duration of action of the patch and improving its efficacy.

[0036] In the mesoporous silica-calcium carbonate composite particles of the present invention, by doping with silica, the stability of calcium carbonate nanoparticles can be improved, the collapse of pore structure can be reduced, and the porosity can be increased and the pore uniformity can be improved, thereby increasing the loading capacity and improving the ability to release the composition smoothly.

[0037] The above is the general concept of the present invention. Based on this, detailed embodiments and comparative examples are provided below to further illustrate the present invention.

[0038] In the following examples and comparative examples: 1. Angelica dahurica extract was prepared by the following method: Angelica dahurica was ball-milled to below 600 mesh, the obtained Angelica dahurica powder was added to ethanol, ultrasonically dispersed for 30 min, then stirred at 70℃ and 500 rpm for 2 h, centrifuged, the supernatant was distilled under reduced pressure and vacuum dried to obtain Angelica dahurica extract; In this context, the volume of ethanol is 30 times the mass of Angelica dahurica powder, measured in mL and g respectively.

[0039] 2. The Xanthium sibiricum extract was prepared by the following method: Xanthium sibiricum was ball-milled to below 600 mesh, the resulting Angelica dahurica powder was added to ethanol, ultrasonically dispersed for 30 min, then stirred at 50℃ and 700 rpm for 3 h, centrifuged, the supernatant was distilled under reduced pressure and vacuum dried to obtain Angelica dahurica extract; In this context, the volume of ethanol is 35 times the mass of Angelica dahurica powder, measured in mL and g respectively.

[0040] 3. Artemisia oil, sesame oil, licorice isoflavone A, ravensardine essential oil, peppermint essential oil, and tea tree essential oil are all commercially available products.

[0041] Example 1 A plant-based composition for treating acute and chronic rhinitis, comprising the following raw material components in parts by weight: 13 parts Artemisia argyi oil; 4.8 parts sesame oil; Licorice isoflavone A 1.6 parts; Two portions of Angelica dahurica extract; 3.5 parts of Xanthium sibiricum extract; 6 parts of Ravensard leaf essential oil; 11 parts peppermint essential oil; 15 parts tea tree oil.

[0042] This embodiment also provides a patch for treating acute and chronic rhinitis, which is prepared by the following method: S1. Preparation of mesoporous silica-calcium carbonate composite particles: Take 2.2g of calcium chloride and 1.5g of hexadecyltrimethylammonium bromide and add them to a mixture of 150mL of deionized water and isopropanol in a volume ratio of 2:1. Stir for 15min, then add 4.2mL of tetraethyl orthosilicate and stir for 60min. Add 15wt% ammonia water to the resulting mixture to adjust the pH to 11. Add 15g of 20wt% sodium carbonate deionized water dropwise while stirring. Stir at 50℃ for 2h, let stand at room temperature for 4h, centrifuge, wash with deionized water, vacuum dry at 100℃ for 6h, and then calcine at 500℃ for 3h to obtain mesoporous silica-calcium carbonate composite particles. S2. Loading plant compositions onto mesoporous silica-calcium carbonate composite particles yields drug-loaded active particles: S2-1. According to the above proportions of plant composition, mix artemisia oil, sesame oil, licorice isoflavone A, angelica extract, cocklebur extract, ravensardine leaf essential oil, peppermint essential oil and tea tree essential oil, stir for 1 hour to obtain plant composition. S2-2. Take 1g of mesoporous silica-calcium carbonate composite particles (i.e., carrier particles) and add them to 20mL of deionized water. Disperse them by ultrasonication for 1h to obtain a carrier dispersion. S2-3. Take 2g of the prepared plant composition for treating acute and chronic rhinitis and add it to a mixture of 40mL of ethanol and deionized water in a volume ratio of 3:1. Stir at 1500rpm for 45min to obtain the composition solution. S2-4. The carrier dispersion was added to the composition solution under stirring at 1000 rpm, and stirring was maintained for 2 hours. The mixture was then shaken on a shaker at room temperature for 8 hours, filtered, and vacuum dried at 50°C for 12 hours to obtain drug-loaded active particles. S3. Preparation of the dressing: S3-1. Add 10g of drug-loaded active particles and 30g of ethanol to 70g of deionized water and sonicate for 1h. Then add 8g of hydroxyethyl cellulose and 5g of methyl cellulose, stir for 45min, and then add 3.5g of sodium hyaluronate. Stir and react for 4h, and let stand at room temperature for 6h to obtain a gel. S3-2. Apply the obtained gel to the surface of medical gauze, controlling the wet coating amount to 1 g / cm³. 2 Vacuum dried at 60℃ for 8 hours, a patch for treating acute and chronic rhinitis was obtained.

[0043] Comparative Example 1 A plant-based composition for treating acute and chronic rhinitis, comprising the following raw material components in parts by weight: 13 parts Artemisia argyi oil; 4.8 parts sesame oil; Licorice isoflavone A 1.6 parts; Two portions of Angelica dahurica extract; 3.5 parts of Xanthium sibiricum extract; 6 parts of Ravensard leaf essential oil; 11 parts peppermint essential oil; 15 parts tea tree oil.

[0044] This embodiment also provides a patch for treating acute and chronic rhinitis, which is prepared by the following method: S1. Preparation of mesoporous calcium carbonate: Take 2.2g of calcium chloride and 1.5g of cetyltrimethylammonium bromide and add them to a mixture of 150mL of deionized water and isopropanol in a volume ratio of 2:1. Stir for 60min. Add 15wt% ammonia water to the mixture to adjust the pH to 11. Add 15g of 20wt% sodium carbonate deionized water dropwise while stirring. Stir at 50℃ for 2h. Let stand at room temperature for 4h. Centrifuge, wash with deionized water, dry under vacuum at 100℃ for 6h, and then calcine at 500℃ for 3h to obtain mesoporous calcium carbonate. S2. Loading plant compositions onto mesoporous calcium carbonate yields drug-loaded active particles: S2-1. According to the above proportions of plant composition, mix artemisia oil, sesame oil, licorice isoflavone A, angelica extract, cocklebur extract, ravensardine leaf essential oil, peppermint essential oil and tea tree essential oil, stir for 1 hour to obtain plant composition. S2-2. Take 1g of mesoporous calcium carbonate (i.e., carrier particles) and add it to 20mL of deionized water. Disperse it by ultrasonication for 1h to obtain a carrier dispersion. S2-3. Take 2g of the prepared plant composition for treating acute and chronic rhinitis and add it to a mixture of 40mL of ethanol and deionized water in a volume ratio of 3:1. Stir at 1500rpm for 45min to obtain the composition solution. S2-4. The carrier dispersion was added to the composition solution under stirring at 1000 rpm, and stirring was maintained for 2 hours. The mixture was then shaken on a shaker at room temperature for 8 hours, filtered, and vacuum dried at 50°C for 12 hours to obtain drug-loaded active particles. S3. Preparation of the dressing: S3-1. Add 10g of drug-loaded active particles and 30g of ethanol to 70g of deionized water and sonicate for 1h. Then add 8g of hydroxyethyl cellulose and 5g of methyl cellulose, stir for 45min, and then add 3.5g of sodium hyaluronate. Stir and react for 4h, and let stand at room temperature for 6h to obtain a gel. S3-2. Apply the obtained gel to the surface of medical gauze, controlling the wet coating amount to 1 g / cm³. 2 Vacuum dried at 60℃ for 8 hours, a patch for treating acute and chronic rhinitis was obtained.

[0045] Comparative Example 2 A plant-based composition for treating acute and chronic rhinitis, comprising the following raw material components in parts by weight: 13 parts Artemisia argyi oil; 4.8 parts sesame oil; Licorice isoflavone A 1.6 parts; Two portions of Angelica dahurica extract; 3.5 parts of Xanthium sibiricum extract; 6 parts of Ravensard leaf essential oil; 11 parts peppermint essential oil; 15 parts tea tree oil.

[0046] This embodiment also provides a patch for treating acute and chronic rhinitis, which is prepared by the following method: S1. Preparation of mesoporous silica: 1.5 g of hexadecyltrimethylammonium bromide was added to a mixture of 150 mL of deionized water and isopropanol in a volume ratio of 2:1 and stirred for 15 min. Then, 4.2 mL of tetraethyl orthosilicate was added and stirred for 60 min. Ammonia solution with a concentration of 15 wt% was added dropwise to the resulting mixture to adjust the pH to 11. The mixture was stirred at 50 °C for 2 h, allowed to stand at room temperature for 4 h, centrifuged, washed with deionized water, dried under vacuum at 100 °C for 6 h, and then calcined at 500 °C for 3 h to obtain mesoporous silica. S2. Loading the plant composition onto mesoporous silica yields drug-loaded active particles: S2-1. According to the above proportions of plant composition, mix artemisia oil, sesame oil, licorice isoflavone A, angelica extract, cocklebur extract, ravensardine leaf essential oil, peppermint essential oil and tea tree essential oil, stir for 1 hour to obtain plant composition. S2-2. Take 1g of mesoporous silica (i.e., carrier particles) and add it to 20mL of deionized water. Disperse it by ultrasonication for 1h to obtain a carrier dispersion. S2-3. Take 2g of the prepared plant composition for treating acute and chronic rhinitis and add it to a mixture of 40mL of ethanol and deionized water in a volume ratio of 3:1. Stir at 1500rpm for 45min to obtain the composition solution. S2-4. The carrier dispersion was added to the composition solution under stirring at 1000 rpm, and stirring was maintained for 2 hours. The mixture was then shaken on a shaker at room temperature for 8 hours, filtered, and vacuum dried at 50°C for 12 hours to obtain drug-loaded active particles. S3. Preparation of the dressing: S3-1. Add 10g of drug-loaded active particles and 30g of ethanol to 70g of deionized water and sonicate for 1h. Then add 8g of hydroxyethyl cellulose and 5g of methyl cellulose, stir for 45min, and then add 3.5g of sodium hyaluronate. Stir and react for 4h, and let stand at room temperature for 6h to obtain a gel. S3-2. Apply the obtained gel to the surface of medical gauze, controlling the wet coating amount to 1 g / cm³. 2 Vacuum dried at 60℃ for 8 hours, a patch for treating acute and chronic rhinitis was obtained.

[0047] Comparative Example 3 The only difference between this example and Example 1 is that licorice isoflavone A is not added to the plant composition.

[0048] Comparative Example 4 A plant-based composition for treating acute and chronic rhinitis, comprising the following raw material components in parts by weight: 13 parts Artemisia argyi oil; 4.8 parts sesame oil; Licorice isoflavone A 1.6 parts; Two portions of Angelica dahurica extract; 3.5 parts of Xanthium sibiricum extract; 6 parts of Ravensard leaf essential oil; 11 parts peppermint essential oil; 15 parts tea tree oil.

[0049] This embodiment also provides a patch for treating acute and chronic rhinitis, which is prepared by the following method: S1. According to the above proportions of plant composition, mix artemisia oil, sesame oil, licorice isoflavone A, angelica extract, cocklebur extract, ravensardine leaf essential oil, peppermint essential oil and tea tree essential oil, stir for 1 hour to obtain plant composition. S2. Preparation of the dressing: S2-1. Add 6.5g of plant composition and 30g of ethanol to 70g of deionized water and sonicate for 1h. Then add 8g of hydroxyethyl cellulose and 5g of methyl cellulose, stir for 45min, and then add 3.5g of sodium hyaluronate. Stir and react for 4h, and let stand at room temperature for 6h to obtain a gel. S2-2. Apply the obtained gel to the surface of medical gauze, controlling the wet coating amount to 1 g / cm³. 2 Vacuum dried at 60℃ for 8 hours, a patch for treating acute and chronic rhinitis was obtained.

[0050] I. Performance Test Examples 1. The drug loading capacity of the drug-loaded active particles in Example 1, Comparative Example 1, and Comparative Example 2 was tested at different oscillation times. The test method was as follows: In step S2-4 of each example, the drug loading of the drug-loaded active particles obtained under different shaking times (2h, 4h, 6h, 8h) is tested. The drug loading is: [mass of drug-loaded active particles obtained in step S2-4 - 1g (i.e., the mass of carrier particles added in step S2-2)] / mass of drug-loaded active particles obtained in step S2-4 * 100%.

[0051] Test results are as follows Figure 1 As shown, it can be seen that with the extension of the shaking time, the drug loading of the drug-loaded active particles in Example 1, Comparative Example 1 and Comparative Example 2 gradually increases, and the drug loading capacity of Example 1 is stronger than that of Comparative Example 1 and Comparative Example 2.

[0052] 2. Testing sustained-release performance (using glycyrrhizin isoflavone A as a representative): 5g of the drug-loaded active particles prepared in Example 1, Comparative Example 1, and Comparative Example 2 were added to 300mL of deionized water and ultrasonically dispersed for 30min to obtain a particle dispersion. The dispersion was then kept at 37℃ and allowed to stand. Every 2 hours, the content of glycyrrhizin A in the particle dispersion was measured (using high-performance liquid chromatography). The release amount of glycyrrhizin A was calculated, and a release curve was plotted with the cumulative percentage of release on the ordinate and the release time (i.e., the standing time) on the abscissa. Cumulative percentage of release = Q t Q0 represents the cumulative release amount within time t, and Q0 represents the total loading of glycyrrhizin A in the drug-loaded active particles (which is the total amount of glycyrrhizin A in the initial composition solution in S2-4 minus the remaining amount of glycyrrhizin A in the composition solution after the removal of the drug-loaded active particles).

[0053] Test results are as follows Figure 2 As shown, the drug-loaded active particles of Example 1 can achieve long-term release of glycyrrhizin A, and can stably release glycyrrhizin A within 48 hours. Although Comparative Examples 1 and 2 can also achieve sustained release of glycyrrhizin A, the release rate is fast in the early stage and too slow in the later stage, and the stability of release is not as good as that of Example 1.

[0054] II. Application Test Cases 1. Subjects: 250 patients with chronic rhinitis who visited the hospital were selected, including 125 males and 125 females, aged between 25 and 55 years. They were randomly divided into 6 groups of 50 each. Groups 5 were designated as experimental groups 1-5, and the remaining experimental group 6 served as the blank control group.

[0055] 2. Diagnostic criteria: 2. Treatment methods Experimental groups 1 to 5 were treated with the patches described in Example 1 and Comparative Examples 1-4, respectively. The patches were cut into strips of 2.5cm × 5cm and applied to the Yingxiang and Bitong acupoints on the nose. The patches were applied once each in the morning, noon and evening for 30 minutes each time. One patch could be reused for 48 hours. The efficacy was evaluated after one month of treatment.

[0056] 3. Efficacy criteria: (1) Rhinitis Symptom Scoring Standard Table: It mainly includes four symptom indicators: sneezing, nasal congestion, runny nose, and nasal itching. The scores are based on the presence and severity of the symptoms. Each symptom is scored from 0 to 4 points (0 points for no symptoms, 1 point for mild symptoms, 2 points for moderate symptoms, 3 points for moderate symptoms, and 4 points for severe symptoms). The total score of the four symptoms is the rhinitis symptom score.

[0057] The test results are shown in Table 1 below. Figure 3 , Figure 4 As shown: Table 1 experimental group Use dressings Average score of each subject before treatment Average score of each subject after treatment Rating decrease percentage / % Experimental group 1 Example 1 8.53 2.17 74.56 Experimental group 2 Comparative Example 1 8.48 3.62 57.31 Experimental group 3 Comparative Example 2 8.59 3.81 55.65 Experimental group 4 Comparative Example 3 8.57 2.95 65.58 Experimental group 5 Comparative Example 4 8.44 4.33 48.70 The percentage decrease in score is calculated as follows: (Average score of each subject before treatment - Average score of each subject after treatment) / Average score of each subject before treatment * 100% The test results show that experimental group 1 had the best treatment effect. In experimental groups 2 and 3, the carrier particles in the patches were not doped with mesoporous silica and mesoporous calcium carbonate, respectively, resulting in a lower loading capacity of the composition and affecting the efficacy. The results of experimental group 4 confirmed that the added glycyrrhizin isoflavone A in the composition could improve the treatment efficacy of rhinitis. In experimental group 5, the lack of drug-loaded active particles prevented sustained-release drug delivery, leading to a significant decrease in treatment effect.

[0058] The above description is merely a preferred embodiment of the present invention and is not intended to limit the present invention in any way. Although the present invention has been disclosed above with reference to preferred embodiments, it is not intended to limit the present invention. Any person skilled in the art can make some modifications or alterations to the above-disclosed technical content to create equivalent embodiments without departing from the scope of the present invention. Any simple modifications, equivalent changes and alterations made to the above embodiments based on the technical essence of the present invention without departing from the scope of the present invention shall still fall within the scope of the present invention.

Claims

1. A plant composition for treating acute and chronic rhinitis, characterized in that, The plant composition comprises the following raw material components by weight parts: Artemisia argyi oil 7.5-20 parts; Sesame oil 3.5-6 parts; Glycyrrhiza flavone A 0.8-2.5 parts; Angelica extract 1.5-4 parts; Xanthium extract 2-6 parts; Ravensara leaf essential oil 3-9 parts; Peppermint essential oil 8-15 parts; Tea tree essential oil 12-24 parts.

2. The plant composition for treating acute and chronic rhinitis as claimed in claim 1, wherein, The angelica extract is prepared by the following method: grinding angelica into 300-800 mesh, adding the angelica powder into ethanol, ultrasonic dispersion for 15-60 min, then stirring at 50-80℃ and 200-1000 rpm for 2h, centrifugation, vacuum distillation of the supernatant, and vacuum drying to obtain the angelica extract; wherein the volume of ethanol is 20-50 times the mass of the angelica powder, both in volume units of mL and mass units of g.

3. The plant composition for treating acute and chronic rhinitis as claimed in claim 2, wherein, The angelica extract is prepared by the following method: grinding angelica into 600 mesh, adding the angelica powder into ethanol, ultrasonic dispersion for 30 min, then stirring at 70℃ and 500 rpm for 2h, centrifugation, vacuum distillation of the supernatant, and vacuum drying to obtain the angelica extract; wherein the volume of ethanol is 30 times the mass of the angelica powder, both in volume units of mL and mass units of g.

4. The plant composition for treating acute and chronic rhinitis as claimed in claim 1, wherein, The xanthium extract is prepared by the following method: grinding xanthium into 400-700 mesh, adding the angelica powder into ethanol, ultrasonic dispersion for 15-60 min, then stirring at 40-60℃ and 500-1000 rpm for 1.5-6h, centrifugation, vacuum distillation of the supernatant, and vacuum drying to obtain the angelica extract; wherein the volume of ethanol is 25-70 times the mass of the angelica powder, both in volume units of mL and mass units of g.

5. The plant composition for treating acute and chronic rhinitis as claimed in claim 4, wherein, The xanthium extract is prepared by the following method: grinding xanthium into 600 mesh, adding the angelica powder into ethanol, ultrasonic dispersion for 30 min, then stirring at 50℃ and 700 rpm for 3h, centrifugation, vacuum distillation of the supernatant, and vacuum drying to obtain the angelica extract; wherein the volume of ethanol is 35 times the mass of the angelica powder, both in volume units of mL and mass units of g.

6. Use of the plant composition of any one of claims 1-5 in the preparation of a medicament for treating acute or chronic rhinitis.

7. A preparation for treating acute and chronic rhinitis, characterized by, It comprises the plant composition of any one of claims 1-5, and the preparation is a plaster, a spray, a liniment, a paste, a powder or a film.

8. A patch for treating acute and chronic rhinitis, characterized by, It comprises a substrate and a gel agent arranged on the substrate, wherein the gel agent comprises the plant composition of any one of claims 1-5.

9. The patch for treating acute and chronic rhinitis according to claim 8, wherein It is prepared by the following method: S1, preparing mesoporous silica-calcium carbonate composite particles: Take 1.1-4.4g calcium chloride, 0.75-3g hexadecyl trimethyl ammonium bromide into 50-300mL deionized water and isopropanol mixed solution consisting of volume ratio 2:1, stirring for 5-30min, then add 2.1-8.4mL tetraethyl orthosilicate, stirring for 30-90min, drop 10-20wt% ammonia water into the resulting mixture to adjust pH to 10-11, drop 7.5-30g 10-30wt% sodium carbonate deionized water solution under stirring, stirring at 40-60℃ for 1-4h, room temperature standing for 2-8h, centrifugation, deionized water washing, vacuum drying, then calcining at 450-550℃ for 1.5-6h, mesoporous silica-calcium carbonate composite particles are obtained; S2, load plant composition on mesoporous silica-calcium carbonate composite particles to obtain drug-loaded active particles: S2-1, according to the ratio of the plant composition, mix mulberry leaf oil, sesame oil, glycyrrhizinate A, Baiji extract, Xiang'erzi extract, rosemary leaf essential oil, peppermint essential oil, tea tree essential oil, stirring for 1h, to obtain plant composition; S2-2, take 0.5-2g mesoporous silica-calcium carbonate composite particles into 10-40mL deionized water, ultrasonic dispersion for 0.5-2h, to obtain carrier dispersion liquid; S2-3, take 1-4g prepared plant composition for treating acute and chronic rhinitis into 20-80mL ethanol and deionized water mixed solution consisting of volume ratio 3:1, stirring at 1000-2000rpm for 30-90min, to obtain composition solution; S2-4, under the stirring of 500-1200rpm, add carrier dispersion liquid into composition solution, keep stirring for 1-4h, shaking bed oscillation at room temperature for 4-12h, filtration, vacuum drying, to obtain drug-loaded active particles; S3, preparation of patch: S3-1, add 5-20g drug-loaded active particles, 15-60g ethanol into 35-140g deionized water, ultrasonic dispersion for 0.5-2h, then add 4-16g hydroxyethyl cellulose, 2.5-10g methyl cellulose, stirring for 30-90min, then add 1.75-7g sodium hyaluronate, stirring reaction for 2-8h, room temperature standing for 3-12h, to obtain gel; S3-2, the obtained gel is applied on the surface of medical gauze, and the wet coating amount is controlled to be 0.5-4 g / cm 2 , vacuum drying at 40-65 ℃ for 4-12 h to obtain the patch for treating acute and chronic rhinitis.

10. The patch for treating acute and chronic rhinitis according to claim 9, wherein It is prepared by the following method: S1, preparation of mesoporous silica-calcium carbonate composite particles: Take 2.2g calcium chloride, 1.5g hexadecyl trimethyl ammonium bromide into 150mL deionized water and isopropanol mixed solution consisting of volume ratio 2:1, stirring for 15min, then add 4.2mL tetraethyl orthosilicate, stirring for 60min, drop 15wt% ammonia water into the resulting mixture to adjust pH to 11, drop 15g 20wt% sodium carbonate deionized water solution under stirring, stirring at 50℃ for 2h, room temperature standing for 4h, centrifugation, deionized water washing, 100℃ vacuum drying for 6h, then calcining at 500℃ for 3h, mesoporous silica-calcium carbonate composite particles are obtained; S2, load plant composition on mesoporous silica-calcium carbonate composite particles to obtain drug-loaded active particles: S2-1, according to the proportion of the plant composition, mix mulberry leaf oil, sesame oil, glycyrrhiza isoflavone A, Bai Zhi extract, Xiang' ezi extract, rosemary leaf essential oil, peppermint essential oil, tea tree essential oil, stir for 1h, get plant composition; S2-2, take 1g mesoporous silica-calcium carbonate composite particles into 20mL deionized water, ultrasonic dispersion for 1h, get carrier dispersion liquid; S2-3, take 2g prepared plant composition for treating acute and chronic rhinitis into 40mL mixed solution of ethanol and deionized water with volume ratio of 3:1, stir at 1500rpm for 45min, get composition solution; S2-4, under the stirring of 1000rpm, add carrier dispersion liquid into composition solution, keep stirring for 2h, shake at room temperature for 8h, filter, vacuum drying at 50℃ for 12h, get drug-loaded active particles; S3, preparation of patch: S3-1, add 10g drug-loaded active particles, 30g ethanol into 70g deionized water, ultrasonic dispersion for 1h, then add 8g hydroxyethyl cellulose, 5g methyl cellulose, stir for 45min, then add 3.5g sodium hyaluronate, stir for 4h, stand at room temperature for 6h, get gelatin; S3-2, the obtained gel is applied on the surface of medical gauze, and the wet coating amount is controlled to be 1 g / cm 2 vacuum drying at 60 °C for 8 h to obtain the patch for treating acute and chronic rhinitis.

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