Neutralization reaction method and system for sucralose

Abstract

The invention belongs to the technical field of sucralose preparation, and particularly relates to a sucralose neutralization reaction method and system.The sucralose neutralization reaction method comprises the steps that S1, chlorination liquid obtained after chlorination reaction is introduced into a neutralization reaction kettle, and circulating cooling is conducted on the chlorination liquid; s2, dropwise adding the circularly cooled ammonia water into a neutralization reaction kettle, and carrying out a neutralization reaction to form a neutralization solution; s3, when the pH value of the neutralization solution is detected to be 9-10, stopping adding the ammonia water; after the neutralization solution is circulated for 10-20 minutes, the PH is measured again, the PH is not changed, and the PH is kept to be 9-10; s4, adding hydrochloric acid into the neutralization reaction kettle, adjusting the pH value of the neutralization solution back to 7-8 through the hydrochloric acid, and stopping adding the hydrochloric acid; and after the neutralization solution is circulated for 10-20 minutes, the pH value is remeasured to be unchanged, the pH value is kept to be 7-8, and then the regulated neutralization solution is pumped to a concentrated drying workshop. The side reaction in the sucralose preparation process is inhibited, and the purity of the sucralose final product is improved.

Description

TECHNICAL FIELD

[0001] The application belongs to the technical field of sucralose preparation, and particularly relates to a sucralose neutralization reaction method and system. BACKGROUND

[0002] Sucralose is a high-intensity sweetener obtained by chlorination reaction using sucrose as raw material. It was developed by Tate & Lyle and the University of London in 1976 and patented, and was put into the market in 1988. The chemical name of sucralose is 4,1',6'-trichloro-4,1',6'-trideoxygalactosucrose, and the molecular formula is C 12 H 19 O8Cl3, and the molecular weight is 397.64 g / mol.

[0003] The functional characteristics of sucralose are as follows: 1) High sweetness: The sweetness of sucralose is about 400 to 800 times that of sucrose.

[0004] 2) Stability: It has high stability at room temperature and different pH values, and does not change chemically after being stored for more than one year.

[0005] 3) Solubility: It is easily soluble in water, and also soluble in organic solvents such as ethanol and methanol.

[0006] 4) Safety: It is not involved in metabolism in the human body, has zero heat value, and is suitable for diabetics.

[0007] 5) No tooth decay: It is not utilized by caries bacteria, and is helpful for anti-caries.

[0008] The biological properties of sucralose are as follows: 1) Metabolism: Sucralose is not absorbed in the human body and is not involved in metabolism.

[0009] 2) FDA certification: In 1998, it was certified by the FDA of the United States and can be used as a general sweetener for all foods.

[0010] Sucralose is widely used in various foods, such as carbonated beverages, still beverages, alcoholic beverages, confectionery, fruit and vegetable cans, pickled foods, sauces, jams, baked goods, ice cream, dairy products, etc.

[0011] In the prior art, the chlorination liquid after chlorination reaction is put into a chlorination neutralization reaction kettle and cooled to -5-5℃, then ammonia water is added dropwise to reach a certain pH value, and then hydrochloric acid is adjusted. In the reaction process, because at a higher temperature, part of the raw materials or intermediates may undergo decomposition, polymerization and other side reactions to generate impurities, which affect the purity of the final sucralose product. SUMMARY

[0012] To solve the technical problem of how to inhibit side reactions in the preparation of sucralose and improve the purity of the final product of sucralose, the present application provides the following technical solutions: In a first aspect, The present application provides a neutralization reaction method for sucralose, comprising: S1. The chlorination liquid after chlorination is introduced into a neutralization reactor, and a first cooling medium is used to circulate and cool the chlorination liquid in the neutralization reactor; S2. When the temperature of the chlorination liquid is reduced to -10℃-5℃, -12℃-15℃ ammonia water cooled by a second cooling medium is added dropwise to the neutralization reactor through an ammonia water regulating valve, and the added ammonia water is neutralized with the cooled chlorination liquid to form a neutralization liquid; during the dropwise addition of the ammonia water, the temperature of the neutralization liquid is controlled to be within 15℃; S3. When the PH of the neutralization liquid in the neutralization reactor is detected to be 9-10, the addition of ammonia water is stopped; after the neutralization liquid in the neutralization reactor is circulated for 10-20 minutes, the PH is re-measured and remains unchanged at PH=9-10; S4. Hydrochloric acid is added to the neutralization reactor, and the PH of the neutralization liquid is adjusted back to 7-8 by the hydrochloric acid, and then the addition of hydrochloric acid is stopped; after the neutralization liquid in the neutralization reactor is circulated for 10-20 minutes, the PH is re-measured and remains unchanged at PH=7-8, and then the adjusted neutralization liquid is pumped to a concentration and drying workshop.

[0013] In a second aspect, The present application provides a neutralization reaction method for sucralose, comprising: S1. The chlorination liquid after chlorination is introduced into a neutralization reactor, and a first cooling medium is used to circulate and cool the chlorination liquid in the neutralization reactor; S2. When the temperature of the chlorination liquid is reduced to -10℃-5℃, -12℃-15℃ ammonia water cooled by a second cooling medium is added dropwise to the neutralization reactor through an ammonia water regulating valve, and the added ammonia water is neutralized with the cooled chlorination liquid to form a neutralization liquid; during the dropwise addition of the ammonia water, the temperature of the neutralization liquid is controlled to be within 15℃; S3. When the PH of the neutralization liquid in the neutralization reactor is detected to be 9-10, and the temperature of the neutralization liquid is controlled to be T=5℃-15℃, the addition of ammonia water is stopped; the neutralization liquid in the neutralization reactor is stirred for a certain period of time, and then the PH is re-measured and remains unchanged; S4. Hydrochloric acid is added to the neutralization reactor, and the PH of the neutralization liquid is adjusted back to 7-8 by the hydrochloric acid, and then the adjusted neutralization liquid is pumped to a concentration and drying workshop.

[0014] Further, the volume of the neutralization reactor is 10 cubic meters.

[0015] Further, the first cooling medium and the second cooling medium are both -15℃ salt water.

[0016] Further, before the chlorinated liquid after chlorination is introduced into the neutralization reactor, it is necessary to confirm that the reactor is empty and open the gas phase channel of the neutralization reactor.

[0017] Further, the ammonia water is added to the neutralization reactor in different drop stages with different drop speeds and different volumes, specifically including: In the first drop stage, the ammonia water regulating valve is at 1 / 3 valve position, a certain volume of ammonia water is added to the neutralization reactor, and the temperature of the neutralization liquid is controlled within -10℃-5℃; In the second drop stage, the ammonia water regulating valve is at 1 / 4 valve position, a certain volume of ammonia water is added to the neutralization reactor, and the temperature of the neutralization liquid is controlled within 0℃-10℃; In the later drop stage, the ammonia water regulating valve is at 2 / 3 valve position, a certain volume of ammonia water is added to the neutralization reactor, and the temperature of the neutralization liquid is controlled within 15℃; In step S3, the neutralization liquid in the neutralization reactor is stirred for a certain time, and the stirring time is 1 hour.

[0018] Further, the total volume of ammonia water added to the neutralization reactor is 1000-1100L, and the concentration of ammonia water is 20%; in the first drop stage, 50L of ammonia water is added to the neutralization reactor; in the second drop stage, 70L of ammonia water is added to the neutralization reactor; and in the later drop stage, the drop volume of ammonia water is the remaining volume of the total ammonia water after the first and second drop stages.

[0019] Further, in step S4, the temperature of the neutralization liquid after being adjusted by hydrochloric acid is controlled within 10℃-25℃.

[0020] Further, the volume of hydrochloric acid drop is 10L-30L, and the concentration is 25%.

[0021] The third aspect, The present application provides a neutralization reaction system for sucralose, characterized in that it comprises a neutralization reactor, a hydrochloric acid high tank, an ammonia water storage tank, an ammonia water condenser, an ammonia water regulating valve and a concentrated dry workshop neutralization liquid tank. The neutralization reactor is used to accommodate the chlorinated liquid after chlorination and the subsequent neutralization reaction site; a jacket in the neutralization reactor is used to introduce a first cooling medium to circulate and cool the chlorinated liquid in the neutralization reactor to -10℃-5℃; The neutralization reactor is connected with the ammonia water storage tank, and the ammonia water storage tank stores pre-cooled ammonia water; An ammonia water condenser is arranged between the ammonia water storage tank and the neutralization reactor, and the ammonia water in the ammonia water storage tank is pumped to the ammonia water condenser and circulated and cooled by a second cooling medium introduced into the ammonia water condenser. An ammonia water regulating valve is arranged on a pipeline connecting the ammonia water condenser and the neutralization reactor, and the circulating cooled ammonia water is added dropwise into the neutralization reactor through the ammonia water regulating valve to react with the chlorination liquid to form a neutralization liquid; A hydrochloric acid high tank is communicated with the neutralization reactor at a high position, and when the addition of ammonia water into the neutralization reactor is completed, the hydrochloric acid in the hydrochloric acid high tank is added dropwise into the neutralization reactor to adjust the pH value of the neutralization liquid. The discharge port of the neutralization reactor is connected to a neutralization liquid tank in a concentration and drying workshop to receive the neutralization liquid adjusted by the hydrochloric acid.

[0022] Further, a neutralization transfer reactor connected to the discharge port of the neutralization reactor is further included, and the neutralization transfer reactor is connected to the neutralization liquid tank in the concentration and drying workshop through a neutralization liquid feeding pump; when the pH value of the neutralization liquid in the neutralization reactor is 7.0-8.0, the pH adjustment is completed, and the adjusted neutralization liquid is first discharged into the neutralization transfer reactor for storage, and then the neutralization liquid feeding pump is used to press the neutralization liquid into the neutralization liquid tank in the concentration and drying workshop.

[0023] Compared with the prior art, the present application has the following beneficial effects: In the present application, the ammonia water is added dropwise into the neutralization reactor after being cooled by circulation, and the chlorination liquid is neutralized after being cooled by circulation. The ammonia water with a lower temperature after being cooled by circulation is relatively safer and easier to control the flow rate and other parameters in the operation links such as conveying and feeding. The volatility of the cooled ammonia water is reduced, which is beneficial to maintaining a good operating environment and accurately adding the material.

[0024] After the ammonia water is cooled by circulation, the neutralization is carried out at a low temperature, which helps to inhibit the side reactions such as decomposition and polymerization of the partial raw materials or intermediate products. The appropriate reaction temperature helps to ensure the stability of the physicochemical properties, and the low temperature condition helps to improve the selectivity of the reaction, so that the effective components in the chlorination liquid are more inclined to react with the ammonia water to generate more target product sucralose-6-ethyl ester, thereby improving the product purity.

[0025] In the sucralose production process, the present application increases the circulation cooling of the ammonia water by the ammonia water condenser, so that more target product sucralose-6-ethyl ester is generated in the extremely low dropwise reaction process, and the content of sucralose-6-ethyl ester in each batch is increased by about 2%, thereby improving the product yield. Each batch produces about 400 kg of sugar, and the market price of one ton of sucralose is about 10,000 yuan, so the value of the process is about 580,000 yuan per year. BRIEF DESCRIPTION OF DRAWINGS

[0026] Figure 1 It is a structural schematic diagram of the neutralization reaction method and system of sucralose. DETAILED DESCRIPTION

[0027] The technical solution of the present invention will be clearly described below with reference to the accompanying drawings. Obviously, the described embodiments are not all embodiments of the present invention. All other embodiments obtained by those skilled in the art without creative effort are within the protection scope of the present invention.

[0028] Example 1 This invention provides a method for sucralose neutralization reaction, comprising: S1. After cooling the chlorinated liquid from the chlorination reaction, discharge it into a 10 cubic meter neutralization reactor and circulate it to cool it down using -15℃ brine. S2. When the temperature of the chlorination solution drops to -10℃~5℃, ammonia water at -12℃~-15℃ is cooled by circulating brine at -15℃. Ammonia water is then added dropwise to the neutralization reactor through the ammonia water regulating valve. The added ammonia water reacts with the cooled chlorination solution to adjust the pH of the chlorination solution and form a neutralized solution. During the dropwise addition process, the temperature of the neutralization reactor is controlled below 15℃. S3. When the pH of the neutralized liquid in the neutralization reactor is detected to be 9~10, stop adding ammonia; circulate the neutralized liquid in the neutralization reactor for 10~20 minutes, and then retest the pH. The pH remains unchanged and is maintained at pH=9~10. S4. Add hydrochloric acid to the neutralization reactor and adjust the pH of the neutralized solution to 7-8. Then stop adding hydrochloric acid. Circulate the neutralized solution in the neutralization reactor for 10-20 minutes and retest the pH. If it remains unchanged, keep it at pH=7-8. After that, pump the adjusted neutralized solution to the concentration and drying workshop.

[0029] Before introducing the chlorinated liquid after the chlorination reaction into the neutralization reactor in step S1, it is necessary to confirm that the reactor is empty and to open the gas phase valve of the neutralization reactor.

[0030] Example 2 like Figure 1 As shown, the present invention provides a method for sucralose neutralization reaction, comprising: S1. Discharge the chlorinated liquid after the chlorination reaction into a 10 cubic meter neutralization reactor at a volume of 8500 liters; use -15℃ brine to circulate and cool the chlorinated liquid in the neutralization reactor; S2. When the temperature of the chlorination solution drops to -10℃~5℃, ammonia water at -12℃~-15℃ is cooled by circulating brine at -15℃. Ammonia water is then added dropwise to the neutralization reactor through the ammonia water regulating valve. Different volumes of ammonia water are added to the neutralization reactor, and the ammonia water reacts with the cooled chlorination solution to form a neutralized solution. The temperature of the neutralized solution is controlled at different stages of the dropwise addition. In the initial dropwise stage, the ammonia water regulating valve is at 1 / 3 position, and ammonia water is slowly added. The heat release is large in the early stage of the dropwise addition. 50L of ammonia water is added to the neutralization reactor. The dropwise addition rate of 50L is relatively slow in the early stage of the dropwise addition. The temperature of the neutralization liquid is controlled within -10℃ to 5℃. In the second dropwise stage, the ammonia water regulating valve is at 1 / 4 position, and ammonia water is slowly added dropwise. 70L of ammonia water is added dropwise into the neutralization reactor, and the temperature of the neutralization liquid is controlled within 0℃~10℃. During the later dropwise addition stage, the ammonia regulating valve is at 2 / 3 position. After adding 120L of ammonia in the initial stage, the dropwise addition rate is accelerated, and the remaining volume of ammonia is added dropwise into the neutralization reactor. The temperature of the neutralization solution is controlled below 15℃; the total ammonia volume is 1000-1100L, and the ammonia concentration is below 20%. S3. When the pH of the neutralization solution in the neutralization reactor is detected to be 9~10 and the temperature of the neutralization solution is controlled at T=5℃~15℃, stop adding ammonia water; stir the neutralization solution in the neutralization reactor for 1 hour, and then retest the pH. The pH remains unchanged. S4. Add hydrochloric acid to the neutralization reactor, and then use hydrochloric acid to adjust the pH of the neutralized solution to 7-8. The temperature of the neutralized solution after adjustment with hydrochloric acid should be controlled at 10℃-25℃. The volume of hydrochloric acid added dropwise is 10L-30L, and the concentration is 25%. Pump the adjusted neutralized solution to the concentration and drying workshop.

[0031] Before introducing the chlorinated liquid after the chlorination reaction into the neutralization reactor in step S1, it is necessary to confirm that the reactor is empty and to open the gas phase valve of the neutralization reactor.

[0032] Example 3 like Figure 1 As shown, the present invention provides a sucralose neutralization reaction system. Figure 1 In this diagram, P represents a pressure sensor, T represents a temperature sensor, L represents a level gauge, and F represents a flow meter.

[0033] A sucralose neutralization reaction system includes a neutralization reaction vessel, a hydrochloric acid high-level tank, an ammonia water storage tank, and a neutralization transfer vessel.

[0034] The neutralization reactor is used to contain the chlorinated liquid after the chlorination reaction and as a place for subsequent neutralization reactions. The jacket of the neutralization reactor is connected to a freezing medium pipeline, which is equipped with a freezing brine regulating valve. When the freezing brine regulating valve is opened to its full position, freezing brine at -15°C is introduced into the freezing medium pipeline to circulate and cool the chlorinated liquid in the neutralization reactor to -10°C to 5°C.

[0035] The neutralization reactor is equipped with a bottom valve, which connects to the reactor's feed valve. A gas phase pipeline with a gas phase valve is located at the top of the reactor. Before discharging chlorinated liquid into the neutralization reactor, ensure the reactor is empty, close the bottom valve, and then sequentially open the feed valve and gas phase valve. Contact the high-temperature control unit to release 8500 liters of the chlorinated liquid from the chlorination reaction into the 10 cubic meter neutralization reactor.

[0036] The neutralization reactor is connected to an ammonia storage tank, which contains pre-cooled ammonia.

[0037] An ammonia condenser is installed between the ammonia storage tank and the neutralization reactor. The ammonia in the ammonia storage tank is pumped to the ammonia condenser by an ammonia feed pump. The ammonia is circulated and cooled by -15℃ brine introduced into the ammonia condenser. The cooled ammonia is then dripped into the neutralization reactor to neutralize with the cooled chlorinated liquid to form a neutralized liquid.

[0038] An ammonia regulating valve is installed on the pipeline connecting the ammonia condenser and the neutralization reactor. By controlling the valve position, the rate at which ammonia is added to the neutralization reactor can be adjusted, either at a constant rate or at different rates in stages. The ammonia is added until the pH of the neutralized solution in the reactor reaches 9–10 and the temperature reaches 5–15°C. At this point, the ammonia regulating valve is closed, and the addition of ammonia stops.

[0039] The ammonia regulating valve is connected to a flow meter on its pipeline. A bypass pipeline is connected in parallel to the flow meter and is equipped with a manual bypass valve. This bypass valve is used to temporarily add ammonia by manually adjusting its position when the ammonia regulating valve malfunctions. During use, the flow meter is used to prevent measurement errors. Once the ammonia regulating valve is repaired, the manual bypass valve is immediately closed and switched to a normally closed, non-operational state.

[0040] The neutralization reactor is connected to a neutralization circulation pump to continuously circulate the neutralized liquid. After the ammonia water is added, the neutralization circulation pump circulates the neutralized liquid with a pH of 9-10 for 10-20 minutes, and the pH is retested; the pH remains unchanged.

[0041] The neutralization reactor is connected to a hydrochloric acid high-level tank at its upper level, and a hydrochloric acid regulating valve is installed on the pipeline between the two. After ammonia water is added dropwise to the neutralization reactor, the hydrochloric acid regulating valve is opened, and hydrochloric acid is added dropwise to the neutralization reactor to adjust the pH value of the neutralized solution until the pH value of the neutralized solution in the neutralization reactor is 7.0-8.0. The neutralized solution with a pH value of 7-8 is circulated through the neutralization circulation pump for 10-20 minutes, and the pH is measured again. If the pH does not change, the concentration and drying workshop is contacted.

[0042] Alternatively, the stirring function of the neutralization reactor can be activated, and the mixture can be stirred for one hour after the ammonia water is added; or the neutralization liquid can be circulated twice by a neutralization circulation pump.

[0043] The outlet of the neutralization reactor is connected to a neutralization transfer vessel, and a discharge valve is installed between the two. When the pH value of the neutralization liquid is 7.0 to 8.0, the discharge valve is opened to send the liquid with a pH value of 7.0 to 8.0 to the neutralization transfer vessel for temporary storage.

[0044] The neutralization transfer vessel is connected to the neutralization liquid tank in the concentration and drying workshop via a neutralization liquid feed pump. The neutralization liquid in the neutralization transfer vessel, after being returned to its original state, is then pumped into the neutralization liquid tank in the concentration and drying workshop using the neutralization liquid feed pump.

[0045] The above technical features constitute the preferred embodiment of the present invention, which has strong adaptability and optimal implementation effect. Non-essential technical features can be added or removed according to actual needs to meet the needs of different situations.

[0046] Finally, it should be noted that the above content is only used to illustrate the technical solution of the present invention, and is not intended to limit the scope of protection of the present invention. Simple modifications or equivalent substitutions made by those skilled in the art to the technical solution of the present invention do not depart from the essence and scope of the technical solution of the present invention.

Claims

1. A method for neutralizing sucralose, characterized in that, include: S1. Pass the chlorinated liquid after the chlorination reaction into the neutralization reactor, and use the first cooling medium to circulate and cool the chlorinated liquid in the neutralization reactor; S2. When the temperature of the chlorination solution drops to -10℃~5℃, ammonia water that has been cooled to -12℃~-15℃ through the second cooling medium circulation is added dropwise to the neutralization reaction vessel through the ammonia water regulating valve. The added ammonia water reacts with the cooled chlorination solution to form a neutralized solution. During the ammonia water addition process, the temperature of the neutralized solution is controlled below 15℃. S3. When the pH of the neutralized liquid in the neutralization reactor is detected to be 9~10, stop adding ammonia; circulate the neutralized liquid in the neutralization reactor for 10~20 minutes, and then retest the pH. The pH remains unchanged and is maintained at pH=9~10. S4. Add hydrochloric acid to the neutralization reactor and adjust the pH of the neutralized solution to 7-8. Then stop adding hydrochloric acid. Circulate the neutralized solution in the neutralization reactor for 10-20 minutes and retest the pH. If it remains unchanged, keep it at pH=7-8. After that, pump the adjusted neutralized solution to the concentration and drying workshop.

2. A method for neutralizing sucralose, characterized in that, include: S1. Pass the chlorinated liquid after the chlorination reaction into the neutralization reactor, and use the first cooling medium to circulate and cool the chlorinated liquid in the neutralization reactor; S2. When the temperature of the chlorination liquid drops to -10℃~5℃, the ammonia water that has been cooled by circulating the second cooling medium at -12℃~-15℃ is added to the neutralization reaction vessel in different stages and at different rates through the ammonia water regulating valve. The ammonia water and the cooled chlorination liquid undergo a neutralization reaction to form a neutralized liquid. The temperature of the neutralized liquid is controlled at different stages of the addition. S3. When the pH of the neutralizing liquid in the neutralization reactor is detected to be 9~10 and the temperature of the neutralizing liquid is controlled at T=5℃~15℃, stop adding ammonia water; stir the neutralizing liquid in the neutralization reactor for a certain period of time, and then retest the pH. The pH remains unchanged. S4. Add hydrochloric acid to the neutralization reactor, then use hydrochloric acid to adjust the pH of the neutralized solution to 7-8, and pump the adjusted neutralized solution to the concentration and drying workshop.

3. A method for neutralizing sucralose according to claim 1 or 2, characterized in that, The neutralization reactor has a volume of 10 cubic meters.

4. A method for neutralizing sucralose according to claim 1 or 2, characterized in that, Both the first and second cooling media are -15℃ brine.

5. The method for neutralizing sucralose according to claim 2, characterized in that, In step S2, ammonia water of different volumes is added to the neutralization reactor at different dropping rates in different dropping stages, specifically including: In the initial first droplet addition stage, the ammonia water regulating valve is at 1 / 3 position, and a certain volume of ammonia water is added droplet into the neutralization reaction vessel. The temperature of the neutralization liquid is controlled within -10℃ to 5℃. In the second dropwise stage, the ammonia water regulating valve is in the 1 / 4 position, and a certain volume of ammonia water is added dropwise into the neutralization reaction vessel. The temperature of the neutralization liquid is controlled within 0℃ to 10℃. During the later dripping stage, the ammonia water regulating valve is in the 2 / 3 position, and a certain volume of ammonia water is dripped into the neutralization reactor. The temperature of the neutralization liquid is controlled within 15℃. In step S3, the neutralization liquid in the neutralization reactor is stirred for a certain period of time, which is 1 hour.

6. The method for neutralizing sucralose according to claim 5, characterized in that, The total volume of ammonia water added to the neutralization reactor is 1000-1100L, and the ammonia water concentration is 20%. In the first dropping stage, 50L of ammonia water is added to the neutralization reactor. In the second dropping stage, 70L of ammonia water is added to the neutralization reactor. The volume of ammonia water added in the later dropping stage is the remaining volume of total ammonia water after the first and second dropping stages.

7. The method for neutralizing sucralose according to claim 2, characterized in that, In step S4, the temperature of the neutralized solution after hydrochloric acid rehydration is controlled between 10°C and 25°C.

8. The method for neutralizing sucralose according to claim 7, characterized in that, In step S4, the volume of hydrochloric acid added dropwise is 10L-30L, and the concentration is 25%.

9. A sucralose neutralization reaction system, characterized in that, This includes a neutralization reactor, a hydrochloric acid high-level tank, an ammonia storage tank, an ammonia condenser, an ammonia regulating valve, and a neutralization liquid tank in the concentration and drying workshop. The neutralization reactor is used to contain the chlorinated liquid after the chlorination reaction, as well as the subsequent neutralization reaction site; the jacket of the neutralization reactor is used to introduce a first cooling medium to circulate and cool the chlorinated liquid in the neutralization reactor to -10℃~5℃. The neutralization reactor is connected to an ammonia storage tank, which contains pre-cooled ammonia. An ammonia condenser is installed between the ammonia storage tank and the neutralization reactor. The ammonia in the ammonia storage tank is pumped to the ammonia condenser and cooled by a second cooling medium introduced into the ammonia condenser. An ammonia regulating valve is installed on the pipeline connecting the ammonia condenser and the neutralization reactor. A certain amount of the circulating and cooled ammonia is dripped into the neutralization reactor through the ammonia regulating valve to neutralize with the chlorination liquid and form a neutralized liquid. The neutralization reactor is connected to a hydrochloric acid high-level tank at its upper part. After the ammonia water is added to the neutralization reactor, a certain amount of hydrochloric acid is added from the hydrochloric acid high-level tank to restore the pH value of the neutralized liquid in the neutralization reactor. The outlet of the neutralization reactor can be connected to the neutralization liquid tank in the concentration workshop to receive the neutralized liquid that has been adjusted by hydrochloric acid.

10. The sucralose neutralization reaction system according to claim 9, characterized in that, It also includes a neutralization transfer vessel connected to the outlet of the neutralization reactor, which is connected to the neutralization liquid tank in the concentration and drying workshop via a neutralization liquid feed pump. When the pH value of the neutralization liquid in the neutralization reactor is 7.0 to 8.0, the pH is adjusted, and the adjusted neutralization liquid is first discharged to the neutralization transfer vessel for storage, and then pumped to the neutralization liquid tank in the concentration and drying workshop using the neutralization liquid feed pump.

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