Tissue cutter and minimally invasive interventional surgical instrument

Abstract

The invention discloses a tissue cutter and a minimally invasive interventional surgical instrument. The tissue cutting device comprises a tissue cutting support and a first tightening wire. The tissue cutting stent comprises a fixing part, a supporting part and an expanding part which are sequentially connected from the near end to the far end in the axial direction. The supporting part and the expanding part can expand in the radial direction so as to form a horn-shaped containing space which is gradually opened from the near end to the far end. The far end of the expansion part is provided with a plurality of first threading holes arranged in the circumferential direction. The first tightening wire penetrates through the first threading hole and can be pulled to close the far end of the expansion part, so that the tissue cutting stent is in a folded state. In the folded state, the expansion part is bent inwards in the radial direction relative to the supporting part. Compared with the prior art, the tissue cutting device has the advantages that a wound required for cutting pathological tissues is small, and an excision area is accurate, so that compared with the prior art, more normal tissues and organs can be reserved when the tissue cutting device is used for implementing a minimally invasive surgery, and pathological changes in the body of a patient can be cut off more minimally invasively and more accurately.

Description

Technical Field

[0001] This invention relates to the field of medical devices, specifically to a tissue harvester and a minimally invasive interventional surgical instrument. Background Technology

[0002] With the rapid popularization and cost reduction of imaging equipment (such as CT / MRI), early-stage tumors can be detected even when patients are asymptomatic, providing conditions for early diagnosis, early treatment, and reducing the mortality rate of cancer patients. For the large number of early-stage tumors found in solid organs, such as lung cancer, liver cancer, breast cancer, and prostate cancer, the corresponding radical treatment technique is mainly surgical resection.

[0003] Currently used surgical resection equipment mainly includes minimally invasive surgical instruments such as thoracoscopes or laparoscopy. However, even these minimally invasive surgical instruments still create relatively large incisions on the body surface and target tissues and organs. Taking single-port thoracoscopy as an example, this surgery requires an incision of at least 3 centimeters on the body surface. This is because thoracoscopes require multiple instruments (various forceps, scissors, hooks, and anastomosing devices, etc.) to be inserted into the body through the incision to operate simultaneously in order to remove and extract early-stage tumors.

[0004] Because a large incision is required, general anesthesia is necessary. Furthermore, the instruments and resection techniques involved are complex, making imaging equipment unusable during the procedure; only the human eye can be relied upon. However, the human eye cannot accurately pinpoint the exact location of the lesion within the organ, often necessitating a wider resection area to ensure the removal of the target lesion. Such extensive resections generally only support linear cuts, leading to the removal of a larger amount of normal tissue and organs.

[0005] The larger the surgical incision, the slower the patient's recovery. The more normal organs are removed, the greater the long-term health impact on the patient. To improve patients' quality of life, it is necessary to provide a minimally invasive treatment method with less trauma. Summary of the Invention

[0006] To at least partially address the problems of the prior art, according to one aspect of the present invention, a tissue harvester is provided, comprising a tissue harvesting scaffold and a first tightening wire. The tissue harvesting scaffold is radially expandable, and the expanded scaffold is funnel-shaped, gradually opening from proximal to distal end, forming a funnel-shaped internal space. A plurality of first threading holes are provided at the distal end of the tissue harvesting scaffold, the plurality of first threading holes being arranged along the circumferential direction of the tissue harvesting scaffold. The first tightening wire passes through the plurality of first threading holes, and the first tightening wire has opposing first and second ends, the first end being fixed to a starting threading hole among the plurality of first threading holes.

[0007] For example, the tissue harvesting scaffold includes a fixing part, a supporting part, and an expanding part. The fixing part, the supporting part, and the expanding part are connected sequentially from the proximal end to the distal end along the axial direction of the tissue harvesting scaffold. The plurality of first suture holes are disposed on the expanding part. The supporting part and the expanding part are expandable in the radial direction to form the content space.

[0008] For example, the expansion portion and the support portion are generally in the form of a mesh structure.

[0009] For example, the support portion includes a plurality of support segments arranged along the circumferential direction of the tissue cutting scaffold, each of the plurality of support segments having a root end and a tip end, the root end being connected to the fixation portion and the tip end being connected to the expansion portion.

[0010] Exemplarily, the expansion portion has a single-layer or multi-layer annular structure, each annular structure including a plurality of expansion segments arranged along the circumferential direction of the tissue harvesting scaffold, each expansion segment being V-shaped such that each expansion segment has two open ends and one pointed end, the open ends of adjacent expansion segments in each annular structure being connected, wherein... When the expansion section has a single-layer annular structure, the opening end is connected to the tip of the plurality of support segments in a one-to-one correspondence, and each expansion segment tip is provided with a first threading hole; When the expansion portion has a multi-layered annular structure, the multi-layered annular structure is arranged along the axial direction, wherein in two adjacent annular structures, the opening end of one annular structure and the tip of the other annular structure are connected in a one-to-one correspondence; and wherein the opening end of the annular structure closest to the support segment is connected in a one-to-one correspondence to the tip of the plurality of support segments, and each expansion segment tip of the annular structure farthest from the support segment is provided with a first threading hole.

[0011] For example, each of the plurality of support segments is rod-shaped, wherein, in the expanded support portion, the plurality of support segments are radial from the root end to the tip end.

[0012] For example, in the expanded support portion, each of the plurality of support segments is Y-shaped such that each of the plurality of support segments includes a root end and two tip ends, wherein the root ends of the plurality of support segments converge with each other, and in any two adjacent support segments, a tip end of one support segment is connected to a tip end of another support segment.

[0013] For example, the tip of the first suture hole is rotated by a predetermined angle in a plane perpendicular to the axial direction, so that the first suture hole forms the predetermined angle with the radial direction of the tissue harvesting scaffold.

[0014] For example, the expansion portion gradually opens from its proximal end to its distal end.

[0015] For example, the expansion portion is bent radially outward relative to the support portion.

[0016] For example, the support portion is provided with a plurality of second threading holes, the plurality of second threading holes being arranged along the circumferential direction of the tissue cutting support, and the tissue cutter further includes a second tightening wire, the second tightening wire passing through the plurality of second threading holes.

[0017] For example, the second tightening wire passes sequentially through the plurality of second threading holes in the circumferential direction, and one end of the second tightening wire is fixed to one of the plurality of second threading holes.

[0018] For example, the fixing part, the supporting part, and the expansion part are formed by cutting the tube along the axial direction.

[0019] For example, the support portion and the expansion portion have a self-expanding function.

[0020] For example, the proximal end of the tissue harvesting scaffold has a central hole that communicates with the content space along the axial direction, and the second end of the first tightening wire passes through the central hole from within the content space.

[0021] For example, the proximal end of the tissue harvesting scaffold is further provided with a through hole, which communicates with the central hole.

[0022] For example, the middle section of the first tightening wire passes sequentially through other threading holes in the plurality of threading holes along the circumferential direction.

[0023] For example, the middle sections of the first tightening wire all pass through the other threading holes in the same direction.

[0024] For example, the middle section of the first tightening wire is interleaved with other thread holes among the plurality of thread holes, so that the first tightening wire forms a mesh structure at the distal end of the tissue cutting scaffold.

[0025] For example, the tissue harvesting scaffold further includes a membrane layer covering the support portion and the expansion portion.

[0026] For example, the membrane layer includes an inner membrane layer and / or an outer membrane layer, the inner membrane layer covers the inner surface of the support portion and the expansion portion, the outer membrane layer covers the outer surface of the support portion and the expansion portion, the inner membrane layer is an insulating membrane layer, and the outer membrane layer is a conductive membrane layer.

[0027] According to another aspect of the present invention, a minimally invasive interventional surgical instrument is also provided, comprising a tissue harvester, a delivery sheath, a pusher, and a connector as described above. A retracted tissue harvesting scaffold is housed within the delivery sheath, the delivery sheath having a proximal opening and a distal opening. The connector connects the pusher and the proximal end of the tissue harvesting scaffold. The pusher extends from the proximal opening of the delivery sheath into the delivery sheath for pushing the tissue harvesting scaffold out from the distal opening of the delivery sheath.

[0028] For example, the connector includes a plurality of elastic claws, and a plurality of slots are provided on the outer surface of the proximal end of the tissue harvesting scaffold. When the connector is located inside the delivery sheath, the plurality of elastic claws are compressed in the radial direction, and the compressed plurality of elastic claws engage with the plurality of slots respectively. When the plurality of elastic claws are outside the delivery sheath, the plurality of elastic claws separate from the plurality of slots in the radial direction.

[0029] For example, the first tightening wire and the tissue harvesting scaffold are conductive.

[0030] For example, the delivery sheath is conductive, the outer surface of the tissue harvesting scaffold is covered with an insulating outer membrane layer, and the connector and the pusher are insulated from the delivery sheath.

[0031] For example, the distal end of the delivery sheath is provided with a water-permeable hole, the tissue harvesting scaffold is covered with a water-resistant membrane layer, and the space between the water-resistant membrane layer and the delivery sheath is connected to the outside through the water-permeable hole.

[0032] For example, the minimally invasive interventional surgical instrument also includes a puncture needle, and the delivery sheath is housed within the puncture needle.

[0033] For example, the first tightening wire and the tissue harvesting scaffold are conductive, the puncture needle is conductive, and the delivery sheath is insulating.

[0034] For example, at least one of the puncture needle, the delivery sheath, and the first tightening wire is provided with a scale.

[0035] For example, when a through hole is provided on the fixing part and the through hole communicates with the central hole, the minimally invasive interventional surgical instrument further includes a pneumatic device for inflating the delivery sheath and / or evacuating the delivery sheath.

[0036] The tissue harvester provided by this invention can be retracted into a delivery sheath before being inserted into the human body. After entering the body, it can expand either by self-expansion or by applying positive pressure to its internal space. After tissue harvesting, the opening of the tissue harvester can be closed to enclose the tissue. During the closing process, the tissue harvester can compress the enclosed tissue to a certain extent. Therefore, inserting and removing the tissue harvester and the harvested tissue only require small incisions. Furthermore, since skin, muscle, fat, and other organs have a certain degree of elasticity, it is possible to cut and remove tissue with a diameter greater than 10 mm through a skin incision of only 2-3 mm. Such small incisions can even heal on their own without sutures. This has the advantage of eliminating the need for general anesthesia during the procedure. Moreover, the surgical instruments and harvesting actions of this invention are simple, thus enabling the surgery to be performed under imaging guidance. This allows for accurate removal of diseased tissue while minimizing damage to normal organs.

[0037] A series of simplified concepts are introduced in the description of the invention, which will be further explained in detail in the detailed description section. This description is not intended to limit the key features and essential technical features of the claimed technical solution, nor is it intended to determine the scope of protection of the claimed technical solution.

[0038] The advantages and features of the present invention will be described in detail below with reference to the accompanying drawings. Attached Figure Description

[0039] The following figures are included as part of this invention for understanding its principles. The figures illustrate embodiments of the invention and their descriptions, serving to explain the principles of the invention. In the figures, Figure 1 This is a schematic diagram of a minimally invasive interventional surgical instrument according to an embodiment of the present invention, wherein the tissue harvesting scaffold is in a retracted state; Figure 2 for Figure 1 A schematic diagram of minimally invasive interventional surgical instruments, in which the tissue harvesting stent is in an expanded state; Figure 3 for Figure 1 A schematic diagram of minimally invasive interventional surgical instruments, in which the tissue harvesting stent is in a retracted state; Figures 4A-4C These are schematic diagrams of multiple angles of a tissue harvesting scaffold according to an exemplary embodiment of the present invention, wherein the tissue harvesting scaffold is in an expanded state; Figure 5 Figure 4 shows a schematic diagram of the tissue harvesting scaffold, in which the tissue harvesting scaffold is in a contracted state. Figures 6A-6BThese are schematic diagrams of multiple angles of a tissue cutter according to a first exemplary embodiment of the present invention, wherein the first tightening wire adopts a Z-shaped winding method; Figure 7 This is a schematic diagram of a tissue slicing device according to a first exemplary embodiment of the present invention, wherein the tissue slicing support is in a retracted state; Figures 8A-8B These are schematic diagrams of various angles of the tissue cutter according to a second exemplary embodiment of the present invention, wherein the first tightening wire adopts a star-shaped winding method; Figures 9A-9B These are schematic diagrams of multiple angles of a tissue cutter according to a third exemplary embodiment of the present invention, wherein the first tightening wire is wound in a loop; Figures 10A-10B These are schematic diagrams showing multiple angles of a tissue cutter according to a fourth exemplary embodiment of the present invention; Figure 11A-11B These are schematic diagrams showing multiple angles of a tissue cutter according to a fifth exemplary embodiment of the present invention; Figure 12 This is a schematic diagram of a tissue harvester according to a sixth exemplary embodiment of the present invention, wherein a membrane layer is covered on the tissue harvesting scaffold; Figure 13 This is a schematic diagram of a tissue harvesting scaffold according to another exemplary embodiment of the present invention; Figures 14A-14B These are schematic diagrams showing the connector and fixing part assembled according to an exemplary embodiment of the present invention; and Figures 15A-15B These are schematic diagrams showing the connector and tissue cutter assembled according to an exemplary embodiment of the present invention.

[0040] The above figures include the following reference numerals: 1, 1', 1'', Tissue harvesting scaffold; 2, Puncture needle; 3, Delivery sheath; 4, 4', Connector; 5, First tightening wire; 6, Pusher; 7, Second tightening wire; 10, Fixing part; 12, Center hole; 14, Through hole; 16, Bayonet; 18, Slot; 20, 20', 20'', Support part; 200, 200', Support section; 210, Root end; 220, 220', Tip end; 22, First support section; 24. Second support section; 242. Second left support section; 244. Second right support section; 30, 30', 30'', expansion section; 310, 310', opening end; 320, 320', tip; 32. Left expansion section; 34. Right expansion section; 40. Content space; 42. Buckle; 44. Elastic claw; 50, 50', first threading hole; 52. Starting threading hole; 60. Outer membrane layer; 70. Second threading hole. Detailed Implementation

[0041] In the following description, numerous details are provided to enable a thorough understanding of the invention. However, those skilled in the art will appreciate that the following description merely illustrates preferred embodiments of the invention, and that the invention can be practiced without one or more of these details. Furthermore, to avoid obscuring the invention, some technical features well-known in the art have not been described in detail.

[0042] To address the challenge of minimally invasive resection of lesions within tissues (excluding cavities such as blood vessels or trachea), this invention provides a tissue harvesting device and a minimally invasive interventional surgical instrument. The tissue harvesting device includes a compressible tissue harvesting scaffold that can be inserted into the tissue to harvest lesions while expanding and moving within the tissue. After harvesting, the scaffold can be retracted to encapsulate the harvested tissue and remove it from the body. The minimally invasive interventional surgical instrument includes this tissue harvesting device. To provide an overall understanding of this invention, the minimally invasive interventional surgical instrument will first be described in detail below.

[0043] Figure 1-3 Three states of a minimally invasive interventional surgical instrument according to an exemplary embodiment of the present invention are shown. The minimally invasive interventional surgical instrument includes a tissue harvester, a delivery sheath 3, a pusher 6, and a connector 4. In one embodiment, the tissue harvester may include a tissue harvesting support 1 and a first tightening wire 5.

[0044] The shrinking tissue harvesting scaffold 1 is housed within a delivery sheath 3. The delivery sheath 3 has a proximal opening at its proximal end and a distal opening at its distal end. The delivery sheath 3 may be tubular. The delivery sheath 3 can be inserted into the patient's body along the axial direction of the tube, with the two ends forming a proximal opening and a distal opening, respectively. In this text, "proximal" and "distal" refer to the surgeon performing the minimally invasive interventional procedure using this instrument; the end closer to the surgeon is the proximal end, and conversely, the end farther from the surgeon is the distal end.

[0045] Connector 4 connects the pusher 6 and the tissue harvesting scaffold 1. Connector 4 can be connected to the tissue harvesting scaffold 1 in a detachable, non-detachable, or self-detachable manner. More specifically, it connects to the proximal end of the tissue harvesting scaffold 1, which will be described in detail later. Detachable connections include snap-fit, threaded connections, and pin insertion. The advantage of detachable connections is that the tissue harvesting scaffold 1 can be disassembled from the connector 4 after use, requiring only the tissue harvesting scaffold 1 to be replaced each time. Non-detachable connections include welding, bonding, and interference fits. A self-detachable connection means that when the binding force on connector 4 is removed, connector 4 can detach from the tissue harvesting scaffold 1 on its own. The binding force can be the radial constraint force applied by the delivery sheath 3. When connector 4 is pushed out of the delivery sheath 3, this binding force is removed, thereby separating connector 4 from the tissue harvesting scaffold 1. Self-detachable connections are suitable for situations where the tissue harvesting scaffold 1 remains in the body after cutting and wrapping tissue. It can be subsequently located and removed surgically along the first tightening wire 5 as needed, or it can spontaneously degrade after long-term implantation.

[0046] The pusher 6 extends into the delivery sheath 3 through the proximal opening of the sheath 3 to push the tissue harvesting scaffold 1 out through the distal opening of the delivery sheath 3. The pusher 6 can push the tissue harvesting scaffold 1 completely or partially out of the delivery sheath 3 via the distal opening. Those skilled in the art can make appropriate choices according to the needs of the surgical procedure. In embodiments where the connector 4 and the tissue harvesting scaffold 1 are connected in a self-detachable manner, the pusher 6 can also push part or all of the connector 4 out of the body.

[0047] Figures 4A-4C and Figure 5 Both illustrate a tissue harvesting scaffold 1 according to an exemplary embodiment of the present invention, wherein Figures 4A-4C The tissue harvesting scaffold 1 is in an expanded state. Figure 5 The tissue harvesting scaffold 1 is in a contracted state.

[0048] The tissue harvesting support 1 is expandable in the radial direction. The expanded tissue harvesting support 1 takes on a trumpet shape, gradually opening from the proximal end to the distal end. The expanded tissue harvesting support 1 forms a trumpet-shaped internal space 40. This internal space 40 is used to accommodate the harvested tissue. Before expansion, the tissue harvesting support 1 can be elongated and rod-shaped, which facilitates its placement within the delivery sheath 3. The distal end of the tissue harvesting support 1 is provided with a plurality of first threading holes 50. The plurality of first threading holes 50 are arranged along the circumferential direction of the tissue harvesting support 1. A first tightening wire 5 passes through the plurality of first threading holes 50. The first tightening wire 5 has opposing first and second ends; the first end is fixed to one of the plurality of first threading holes 50. The second end can be used for lifting and closing.

[0049] In one specific embodiment, as shown in the figure, the tissue harvesting scaffold 1 may include a fixing part 10, a supporting part 20, and an expansion part 30.

[0050] The fixation part 10, the support part 20, and the expansion part 30 are arranged sequentially along the axial direction of the tissue harvesting scaffold 1 (i.e., the extension direction of the axis PP shown in the figure). In use, the fixation part 10 is located at the proximal end of the tissue harvesting scaffold 1, and the expansion part 30 is located at the distal end of the tissue harvesting scaffold 1. The support part 20 connects between the fixation part 10 and the expansion part 30. The proximal end of the support part 20 is connected to the fixation part 10. The proximal end of the expansion part 30 is connected to the distal end of the support part 20.

[0051] The expansion portion 30 and the support portion 20 are expandable in the radial direction. The fixing portion 10 does not have an expansion function; therefore, under the constraint of the fixing portion 10, the expanded expansion portion 30 and the support portion 20 form a trumpet shape that gradually opens from the proximal end to the distal end. Preferably, the ratio of the outer diameter of the distal end of the trumpet to that of the proximal end is greater than 5:1. The expanded expansion portion 30 and the support portion 20 together form a trumpet-shaped internal space 40.

[0052] Exemplarily, the expansion portion 30 and the support portion 20 can be made of any material capable of expansion and contraction, such as an elastic material. When not under external force, the expansion portion 30 and the support portion 20 are funnel-shaped; when subjected to radially inward pressure, the elastic material can be compressed, and the expansion portion 30 and the support portion 20 can contract. Figure 5 The shape shown allows it to be accommodated within the delivery sheath 3.

[0053] For example, the expansion portion 30 and the support portion 20 are integrally formed into a mesh structure. Although the material forming this mesh structure may not be elastic, the mesh structure allows the expansion portion 30 and the support portion 20 to expand and contract. In this case, optionally, the expansion portion 30 and the support portion 20 may be made of a shape memory material (e.g., a shape memory alloy). When not subjected to external force, the expansion portion 30 and the support portion 20 are funnel-shaped; when subjected to radially inward pressure, the expansion portion 30 and the support portion 20 can contract. Figure 5 The shape shown allows it to be accommodated within the delivery sheath 3. Optionally, the expansion portion 30 and the support portion 20 can be made of a deformable material. After the tissue harvesting scaffold 1 is placed inside the human body, positive pressure can be applied within the content space 40, for example, by filling the content space 40 with gas or liquid, causing the expansion portion 30 and the support portion 20 to expand. Of course, the expansion portion 30 and the support portion 20 can also adopt a mesh structure made of an elastic material. Figures 4A-4C Only one style of mesh structure is shown in the figure. In other embodiments not shown, the mesh structure may have other styles, as long as it can achieve its function.

[0054] When the expansion portion 30 and the support portion 20 are made of elastic or shape memory materials, they can be allowed to have a self-expanding function. Alternatively, the expansion portion 30 and the support portion 20 may not have a self-expanding function, but instead rely on external force (such as positive pressure, as described below) to expand to the desired shape after the delivery sheath 3 is ejected. Both sets of embodiments have their own advantages. The self-expanding function of the expansion portion 30 and the support portion 20 allows them to automatically expand to the desired shape after the delivery sheath 3 is ejected, thus simplifying the doctor's operation. In embodiments where external force is required to compel the expansion portion 30 and the support portion 20 to expand after the delivery sheath 3 is ejected, the external force can help the stent expand in denser tissues (such as dense breast tissue, prostate gland, etc.).

[0055] Multiple first threading holes 50 may be provided at the distal end of the expansion portion 30. Optionally, the multiple first threading holes 50 may be uniformly provided at the distal end along the circumferential direction of the expansion portion 30. Optionally, the multiple first threading holes 50 may also be provided at unequal intervals.

[0056] The fixing part 10 is used to connect with the pusher 6. The fixing part 10 may have a central hole 12. Preferably, the central hole 12 can extend through the fixing part 10 in the axial direction. The central hole 12 communicates with the content space 40. The first tightening wire 5 can extend into the content space 40 through the central hole 12, and the first tightening wire 5 extending into the content space 40 passes through a plurality of first threading holes 50, such as... Figures 6A-6B As shown, when the doctor pulls on the second end of the first tightening wire 5 proximally, the distal end of the expansion portion 30 gradually closes, thereby enveloping the tissue that has entered the content space 40, as... Figure 3 and Figure 7 As shown. Doctors can remove them as needed, leave them temporarily in the body, or allow them to degrade spontaneously after long-term implantation. Optionally, the fixation part 10 may not have a central hole 12. The first tightening wire 5 can extend from the support part 20 near the fixation part 10 into the content space 40.

[0057] By employing the tissue extractor provided by this invention, it can be retracted and placed into the delivery sheath 3 before being inserted into the human body. After entering the human body, it is pushed out of the delivery sheath 3 by the pusher 6. After being pushed out, the tissue extractor can expand on its own or by applying positive pressure to the internal space 40. Therefore, only a very small diameter delivery sheath 3 is needed to insert the tissue extractor into the human body. After tissue extraction, the opening of the tissue extractor can be closed by the first tightening wire 5, encasing the tissue inside. During the closing process, the tissue extractor can compress the encased tissue to a certain extent. Therefore, removing the tissue extractor and the extracted tissue only requires a small incision. Furthermore, since organs such as skin, muscle, and fat have a certain degree of elasticity, it is practically possible to cut and extract tissue with a diameter greater than 10 mm through a skin incision of 2-3 mm. Such a small incision can even heal itself without sutures. The advantages of this are that general anesthesia is not required during the procedure, and compared to thoracoscopy or laparoscopy, the surgical instruments of this invention are simpler and the cutting movements are easier, thus enabling the surgery to be performed under imaging guidance. This allows for accurate removal of diseased tissue while minimizing damage to normal organs.

[0058] In summary, minimally invasive surgery using the tissue harvester provided by this invention results in smaller wounds on the body surface and target tissues and organs, and allows for precise removal of only diseased tissue while preserving more normal tissues and organs. This leads to less damage to the patient, faster recovery, and better long-term quality of life.

[0059] By way of example, the support portion 20 includes a plurality of support segments 200 arranged along the circumferential direction of the tissue harvesting scaffold 1. Each support segment 200 has a root end 210 and a tip end 220. The root end 210 is connected to the fixation portion 10. The tip end 220 is connected to the expansion portion 30.

[0060] In a preferred embodiment, each support segment 200 is Y-shaped, thereby each support segment includes a root end 210 and two tip ends 220, see also [link to previous document]. Figures 4A-4B In the expanded support section, the root ends 210 of multiple support segments 200 converge with each other, and in any two adjacent support segments, one end 220 of one support segment is connected to one end 220 of the other support segment.

[0061] That is, each support segment 200 may include a first support segment 22 and a pair of second support segments 24. Thus, for the expanded support portion 20, the plurality of first support segments 22 are radially arranged from proximal to distal. The included angles between adjacent first support segments 22 may be equal or unequal. The proximal ends of the plurality of first support segments 22 are connected to the fixing portion 10. The distal ends of the plurality of first support segments 22 are connected to the second support segments 24. For clarity, the pair of second support segments 24 included in each support segment 200 will be referred to as the second left support segment 242 and the second right support segment 244. For any two adjacent support segments 200, the second left support segment 242 of one support segment 200 and the second right support segment 244 of the other support segment 200 are connected at the tip 220. In other words, for each pair of second support segments 24, the second left support segment 242 is connected to the second right support segment 244 of the adjacent support segment 200 on the left at the tip 220, and the second right support segment 244 is connected to the second left support segment 242 of the adjacent support segment 200 on the right at the tip 220. Thus, the expanded support portion 20 branches out in a tree-like pattern along the direction from the proximal end to the distal end.

[0062] In this way, while ensuring that the support portion 20 has sufficient and uniform radial support strength, the axial length of the support section 200 can be extended, thereby allowing the tissue harvesting scaffold 1 to have a sufficiently large radial dimension and internal space, so that a sufficient amount of diseased tissue can be harvested each time. Furthermore, along the axial direction, the support portion 20 can have relatively uniform mesh openings, preventing the tissue encased within it from passing through larger mesh openings and protruding outside the support portion 20, which would cause the radial dimension of the support portion 20 in its closed state to be uneven at various locations.

[0063] In another preferred embodiment, each of the plurality of support segments 200' is rod-shaped, such as Figures 10A-10B As shown, within the expanded support portion 20', multiple support segments 200' radiate from the root to the tip, resembling umbrella ribs. While maintaining the same stent expansion diameter, this approach shortens the axial dimension of the expanded stent, reduces the volume of the internal space 40, and decreases the amount of tissue that can be resected in a single procedure. However, it simultaneously shortens the axial dimension of the compressed tissue harvesting stent 1' and reduces the stent release distance (the distance between the delivery device and the target lesion before stent release), making it suitable for cases where the lesion is close to the organ margin. Physicians can select the appropriate tissue harvesting stent as needed.

[0064] Exemplarily, the expansion portion may have a single-layer or multi-layer annular structure. Each annular structure includes multiple expansion segments arranged along the circumferential direction of the tissue harvesting scaffold. Each expansion segment is V-shaped, such that each expansion segment has two open ends and a pointed end, and the open ends of adjacent expansion segments in each annular structure are connected.

[0065] See back Figures 4A-4C Each expansion section 30 has a single-layer annular structure. Each expansion section 30 includes multiple expansion segments 300. Each expansion segment 300 is V-shaped, with the opening of the V-shape facing proximally. That is, the two open ends 310 of each expansion segment 300 are located at the proximal end of the expansion segment 300, and the tip 320 of each expansion segment 300 is located at the distal end of the expansion segment 300. For clarity in the following description, the two sides of the V-shape are respectively designated as the left expansion segment 32 and the right expansion segment 34. The left expansion segment 32 and the right expansion segment 34 are connected to each other at their distal ends to form a tip 320. The proximal ends of the left expansion segment 32 and the right expansion segment 34 are spaced apart to form two open ends 310, but the open ends 310 of adjacent expansion segments 300 are connected to each other to form an annular structure. Furthermore, the open ends 310 are connected one-to-one to the tips 220 of multiple support segments 200.

[0066] In the illustrated embodiment, for each pair of second support segments 24, the second left support segment 242 connects to the left expansion segment 32, and the second right support segment 244 connects to the right expansion segment 34. Thus, a pair of second support segments (i.e., the second left support segment 242 and the second right support segment 244) and a pair of expansion segments (i.e., the left expansion segment 32 and the right expansion segment 34) are connected to form a small loop. Along the circumferential direction of the tissue harvesting scaffold 1, adjacent small loops connect to form a large loop. In this way, a stable structure can be obtained.

[0067] Each expansion section 300 has a first threading hole 50 at its tip 320. Thus, the first threading holes 50 can be evenly distributed at the distal end of the expansion section 30. When the first tightening wire 5 passes through the first threading hole 50, as... Figure 6A As shown, when the doctor pulls the first tightening wire 5, the first tightening wire 5 first pulls the distal end of the expansion section 30 inward. As the first tightening wire 5 is fully tightened, the distal end of the expansion section 30 is completely closed, as... Figure 7 As shown, the cut tissue can be contained within the content space 40.

[0068] exist Figures 10A-10B In the illustrated embodiment, since each support segment 200' has only one tip 220', the two open ends 310' of each expansion segment 300' are respectively connected to two support segments 200', and each support segment 200' is connected to one open end 310' of each of two adjacent expansion segments 300'.

[0069] Although not shown in the figures, those skilled in the art will recognize from the disclosure of this invention that, in the case where the expansion portions 30 and 30' have a multi-layered annular structure, the multi-layered annular structure can be arranged along the axial direction. That is, in two adjacent annular structures, the open end of one annular structure and the tip of the other annular structure are connected in a one-to-one correspondence. For Figures 10A-10B In the illustrated embodiment, if another annular structure is added, it can be assumed that the two tips of each expansion segment included in the added annular structure are respectively connected to the two tips 320' of the two expansion segments 300'. Of course, more annular structures can be added. The opening end 310' of the annular structure closest to the support segment 200' is connected one-to-one to the tip ends 220' of the multiple support segments 200', and each tip of the expansion segment of the annular structure furthest from the support segment 200' is provided with a first threading hole. It should be noted that the expansion portion of the multi-layer annular structure can also be combined with the support portion of the Y-shaped support segment.

[0070] For example, the expansion portion 30 and the support portion 20 have a relatively thin thickness along the radial direction of the tissue harvesting scaffold 1, thereby allowing the expansion portion 30 and the support portion 20 to expand and contract in the radial direction. The width of the expansion portion 30 and the support portion 20 is greater than that in the thickness direction. The width refers to the dimension of each expansion segment 300 of the expansion portion 30 and each first support segment 22 and second support segment 24 of the support portion 20 along the circumferential direction of the tissue harvesting scaffold 1. Therefore, the first suture hole 50 extends along the radial direction of the tissue harvesting scaffold 1, as... Figures 6A-6B As shown, this is more conducive to ensuring that the tip 320 of the first thread hole 50 has sufficient mechanical strength.

[0071] In a preferred embodiment, the fixing portion 10, the supporting portion 20, and the expanding portion 30 are formed by cutting a tube along the axial direction. This tube can have a relatively thin wall thickness. Forming the tissue harvesting scaffold 1 by cutting a tube is crucial because the thin scaffold structure formed by cutting the tube not only provides the strongest radial support but also provides sufficient rigidity to ensure that the tissue harvesting scaffold 1 does not twist during its advancement within the tissue, thus allowing it to expand smoothly to the predetermined size in solid organs. Furthermore, the integrated scaffold structure ensures the smallest possible outer diameter after compression, reducing the risk of puncture; and it is more suitable for maintaining its shape and advancing in solid organs with resistance. This is something that mesh-woven structures or rod-shaped expanding structures cannot achieve. Of course, the present invention does not exclude the possibility that the mesh structure of the supporting portion 20 and the expanding portion 30 is an embodiment of a mesh-woven structure or a rod-shaped expanding structure.

[0072] As previously described, the first end of the first tightening wire 5 can be fixed to the starting threading hole 52 among the plurality of threading holes 50. After passing through the other threading holes, the first end can extend from within the internal space 40 through the central hole 12 on the fixing part 10 to the outside. The first tightening wire 5 and the other threading holes are all connected by a sliding connection. When the doctor pulls the first tightening wire 5 outside the body to retract the tissue harvesting stent 1, the first tightening wire 5 remains connected to the tissue harvesting stent 1.

[0073] Furthermore, the first tightening wire 5 can be wound around the tissue harvesting scaffold 1 in various ways.

[0074] In a preferred embodiment, the first tightening wire 5 is wound in a Z-shape. For example... Figures 6A-6B As shown, the first end of the first tightening wire 5 is fixed to the starting threading hole 52, and the middle section of the first tightening wire 5 passes through other threading holes sequentially along the circumferential direction. Preferably, the middle sections of the first tightening wire 5 all pass through other threading holes in the same direction. In this way, when the tissue harvesting support 1 is in the retracted state, two adjacent first threading holes 50 may not be completely close together along the circumferential direction of the tissue harvesting support 1 due to the action of the first tightening wire 5, and they also tend to be spaced apart from each other along the radial direction. Taking the case of passing through other threading holes sequentially from the inside to the outside as an example, the next threading hole tends to be located radially outside the previous threading hole, and there will also be a certain gap between them along the circumferential direction. Therefore, when the first tightening wire 5 is tightened, there will be multiple bends at multiple first threading holes 50, thus having a certain self-locking effect, and the tissue harvesting support 1 is not easy to expand.

[0075] In another preferred embodiment, after the first end of the first tightening wire 5 passes through the initial threading hole 52, the middle section of the first tightening wire 5 is alternately threaded through other threading holes, so that the first tightening wire 5 forms a mesh structure at the distal end of the tissue harvesting scaffold 1. Figures 8A-8B The diagram illustrates one method of winding the first tightening wire 5 to form a mesh structure. In other embodiments not shown, the first tightening wire 5 can be wound in other ways, as long as a mesh structure is formed. The advantage of this winding method is that, as the tissue harvesting scaffold 1 travels within the tissue, the mesh-like first tightening wire 5 at its front end can have the function of cutting the tissue, facilitating the shredding of the tissue. Therefore, those skilled in the art can set the mesh size of the mesh structure as needed to obtain the desired degree of tissue shredding. After the tissue is shredded, the shredded tissue is wrapped around the tissue harvesting scaffold 1, making it easier for the tissue to be compressed even smaller after the tissue harvesting scaffold 1 is closed, thereby further ensuring a smaller wound size.

[0076] In yet another preferred embodiment, such as Figures 9A-9BAs shown, in this embodiment, the tip 320' of the expansion section rotates by a predetermined angle relative to the tip 320 in the previous embodiment, within a plane perpendicular to the axial direction PP of the tissue harvesting scaffold 1, thereby making the suture hole on the tip 320' form the predetermined angle with the radial direction of the tissue harvesting scaffold 1. In the previous embodiment, the first suture hole 50 on the tip 320 extends along the radial direction of the tissue harvesting scaffold 1. As the tip 320' rotates in a plane perpendicular to the axis PP, the first suture hole 50' on it also rotates accordingly, and the two rotate by the same angle. Figures 9A-9B The diagram shows a case where the first threading hole 50' is rotated 90 degrees relative to the tip 320, with the rotated first threading hole 50' extending along the circumferential direction of the tissue harvesting scaffold 1. This results in fewer bends after the first tightening wire 5 passes through all the first threading holes 50', thus reducing resistance as the first tightening wire 5 moves relative to the first threading holes 50'. This helps to minimize the frictional resistance between the first tightening wire 5 and the first threading holes 50' during the expansion of the tissue harvesting scaffold from a compressed state to an expanded state, preventing it from fully expanding to the desired size. However, in other embodiments not shown, the tip 320' can also be rotated at any other arbitrary angle. Those skilled in the art can rotate the appropriate angle as needed, thereby adjusting the coefficient of friction of the sliding connection between the first threading hole 50' and the first tightening wire 5, and the closing effect of the tissue harvesting scaffold 1. This method of threading the first tightening wire 5 is referred to herein as the annular threading method.

[0077] In the aforementioned embodiments, when the first tightening wire 5 is wound around the distal end of the tissue harvesting scaffold 1 to form a mesh structure, the tissue can be cut primarily using the first tightening wire 5 during the process, supplemented by the distal edge of the tissue harvesting scaffold 1. In other embodiments, such as Z-shaped winding and ring winding, the effect of cutting tissue using the first tightening wire 5 and the distal edge of the tissue harvesting scaffold 1 is not particularly ideal. In this case, optionally, the tissue harvesting scaffold 1 can be made conductive. Simultaneously, the first tightening wire 5 is also conductive. Thus, the tissue harvesting scaffold 1 and the first tightening wire 5 can form the positive electrode in an electrical circuit, forming a unipolar electrosurgical circuit with the negative electrode plate attached to the body surface, thereby performing electrical treatments such as electro-cutting, electrocoagulation, or radiofrequency ablation on the tissue during travel and during the expansion of the tissue harvesting scaffold 1.

[0078] In a further preferred embodiment, see [link to previous section] Figure 1-3The delivery sheath 3 is conductive, serving as one electrode, while the tissue harvesting scaffold 1 and the first tightening wire 5 serve as the other electrode, thus forming a bipolar electrosurgical circuit. In this case, the outer surface of the tissue harvesting scaffold 1 can be covered with an insulating outer membrane layer 60, as shown in Figure 10. Furthermore, the connector 4 and the pusher 6 are insulated from the delivery sheath 3. Optionally, the connector 4 and the pusher 6 can be made of insulating material, or an insulating layer can also be formed on the outer surfaces of the connector 4 and the pusher 6. Thus, by forming a bipolar electrosurgical circuit, energization can be initiated during the travel and expansion of the tissue harvesting scaffold 1, allowing for electrosurgical cutting of the tissue.

[0079] In another further preferred embodiment, the puncture needle 2 is conductive, serving as one electrode, while the tissue harvesting scaffold 1 and the first tightening wire 5 serve as the other electrode, thereby forming a bipolar electrosurgical circuit. In this case, the delivery sheath 3 can be insulated. Optionally, the delivery sheath 3 can be made of an insulating material, or an insulating layer can also be formed on the outer surface of the delivery sheath 3. Thus, by forming a bipolar electrosurgical circuit, energization can be initiated during the travel and expansion of the tissue harvesting scaffold 1, enabling electrosurgical cutting of the tissue.

[0080] By forming the aforementioned monopolar and bipolar electrosurgical circuits, electrocoagulation hemostasis can be performed during or after tissue cutting. Furthermore, the bipolar electrosurgical circuit offers more stable electrical performance compared to the monopolar circuit. Simultaneously, ablation can be performed outside the needle tract or cutting area to kill any unresected, locally scattered tumor cells.

[0081] In another preferred embodiment, such as Figure 11A-11B As shown, the support section 200 may be provided with a plurality of second threading holes 70, which are arranged along the circumferential direction of the tissue harvesting scaffold. Along the axial direction, the plurality of second threading holes 70 may be located in the middle of the support section 200 or at its distal end. The tissue harvester also includes a second tightening wire 7, which passes through the plurality of second threading holes 70. Thus, when the tissue harvesting scaffold is in a retracted state, the second tightening wire 7 can be pulled externally to further reduce the radial dimension of the retracted tissue harvester and compress the harvested tissue within its internal space, allowing the retracted tissue harvester to be removed through a smaller incision.

[0082] The second tightening wire 7 passes sequentially through a plurality of second threading holes 70 in the circumferential direction. The second tightening wire 7 can pass through each second threading hole 70 in the same direction. The second tightening wire 7 can also pass through each second threading hole 70 in different directions, for example, the second tightening wire 7 can pass through adjacent second threading holes 70 in different directions. One end of the second tightening wire 7 is fixed to a second threading hole 70, and the other end protrudes from the content space. If the proximal end of the tissue harvesting scaffold has a central hole 12, the other end can protrude from the central hole 12, as shown. If no central hole is provided, the other end can protrude from any suitable position near the proximal end of the tissue harvesting scaffold. In other embodiments not shown, the second tightening wire 7 can also pass through the plurality of second threading holes 70 in other winding methods. For example, the second tightening wire 7 can employ any of the various winding methods of the first tightening wire 5. The advantage of the second tightening wire 7 passing sequentially through the plurality of second threading holes 70 in the circumferential direction is that the second tightening wire 7 does not affect the utilization rate of the content space.

[0083] Figure 13 The diagram schematically illustrates a tissue harvesting scaffold 1'' according to another exemplary embodiment of the present invention, wherein the expansion portion 30'' of the tissue harvesting scaffold 1'' gradually opens from its proximal end to its distal end. The expansion portion 30'' forms an angle with the overall direction of travel (i.e., along the axis PP), thereby allowing the expansion portion 30'' to expand prematurely before the support portion 20'' fully extends from the delivery sheath, enabling preliminary tissue cutting. This reduces the radial resistance encountered by the tissue harvesting scaffold during expansion release, resulting in a more stable expansion size. Along the extension direction of the axis PP, the angles between the various portions of the expansion portion 30'' and the axis PP can be the same or different. Preferably, in the case of different angles, the angle between the expansion portion 30'' and the axis PP can gradually increase from the proximal end to the distal end, thereby facilitating the expansion portion 30'' to expand and open within the tissue.

[0084] More preferably, the expansion portion 30'' is bent outward relative to the support portion 20''. The small angle between the support portion 20'' and the axis PP ensures that the tissue harvesting scaffold 1'' has sufficient axial dimensions to form a sufficiently deep content space. The large angle between the expansion portion 30'' and the axis PP reduces the radial resistance experienced by the expansion portion 30'' and the support portion 20'' during expansion, resulting in a more stable expansion size.

[0085] Optionally, any of the aforementioned tissue harvesting scaffolds may further include a membrane layer. (See also...) Figures 4A-4CTaking the illustrated embodiment as an example, Figure 10 shows the structure after the membrane layer is applied. The membrane layer can cover the support portion 20 and the expansion portion 30. The membrane layer may include an inner membrane layer, an outer membrane layer, or both. The inner membrane layer covers the inner surfaces of the support portion 20 and the expansion portion 30. The outer membrane layer 60 (see Figure 10) covers the outer surfaces of the support portion 20 and the expansion portion 30. By covering the support portion 20 and the expansion portion 30 with a membrane layer, effective isolation between diseased tissue and healthy tissue can be ensured during and after the cutting process. From the perspective of isolating diseased tissue and healthy tissue, the membrane layer does not need to be completely sealed; it only needs to be able to isolate cells.

[0086] After the expansion portion 30 has completely closed, electroablation can continue to be applied to inactivate the unresected tissue. In this case, preferably, the outer membrane layer can be a conductive membrane layer that participates in the ablation, while the inner membrane layer needs to be an insulating membrane layer to protect the biological properties of the excised tissue from damage for pathological diagnosis.

[0087] Alternatively, both the inner and outer membrane layers can be made of insulating film. This allows the inner and outer membrane layers to use the same material, thus simplifying the processing and reducing costs.

[0088] Preferably, the fixing part 10 is provided with a through hole 14, which communicates with the central hole 12, such as... Figure 12 As shown. When the support portion 20 and the expansion portion 30 are covered with a membrane layer, see also [reference needed]. Figure 1-3 An airway can be formed inside the delivery sheath 3 and outside the tissue harvesting scaffold 1. During expansion, positive pressure gas can be delivered from the proximal end into the delivery sheath 3 and then through the through-hole 14 and the central hole 12 into the content space. Since the front end of the tissue harvesting scaffold 1 is located within the tissue, the support portion 20 and the expansion portion 30 can be expanded by the positive pressure gas. After expansion and shaping, a negative pressure can be formed within the delivery sheath 3 and the content space, thereby drawing in more tissue to be harvested.

[0089] Therefore, in this case, the interventional surgical instruments also include a pneumatic device for inflating and / or evacuating the delivery sheath 3 to create the aforementioned positive and negative pressures.

[0090] Furthermore, when the fixation part 10 is provided with a through hole 14, the tissue harvesting support 1 is in the extended position. Figure 2 As shown, the tissue harvesting scaffold 1 does not completely detach from the delivery sheath 3, but rather rests against the edge of the distal opening of the delivery sheath 3. Because the fixation part 10 remains inside the delivery sheath 3, leakage of cell tissue along the through-hole 14 will not occur.

[0091] In another preferred embodiment, the distal end of the delivery sheath 3 may be provided with a water-permeable hole (not shown), and the tissue harvesting scaffold 1 may be covered with a water-resistant membrane layer. The space between the water-resistant membrane layer and the delivery sheath 3 is connected to the outside through the water-permeable hole. Thus, conductive water can be delivered into the tissue through the delivery sheath 3 and the water-permeable hole, thereby improving the conductivity of the electrode and making the conductivity of the tissue more uniform, which is beneficial for electroresection. Simultaneously, it can also reduce the temperature of the local tissue during the electroresection process. If the temperature of the surrounding tissue is too high during the electroresection process, it may adhere to the tissue harvesting scaffold 1. By delivering liquid, not only can the temperature of the tissue and the tissue harvesting scaffold 1 be cooled, but the tissue can also be moisturized, preventing the tissue harvesting scaffold 1 from sticking to the tissue.

[0092] Figures 14A-14B A preferred embodiment of the connector 4 is also shown. The distal end of the connector 4 may be provided with a plurality of latches 42, which are distributed circumferentially with gaps between adjacent latches 42, thereby allowing the latches 42 to have a certain degree of elasticity. The fixing part 10 may be provided with slots 16 corresponding to the latches 42. When a radially outward force is applied to the latches 42, the latches 42 can open and engage with the slots 16.

[0093] Figures 15A-15B Another preferred embodiment of connector 4 is shown. Connector 4' includes multiple resilient claws 44, and multiple slots 18 are provided on the outer surface of the fixing portion 10 of the tissue scaffold 1. When connector 4 is located inside the delivery sheath 3, as... Figure 1-3 As shown, multiple elastic claws 44 are compressed radially, meaning the elastic claws 44 are subjected to a radially inward force applied by the delivery sheath 3. At this time, the multiple elastic claws 44 engage with the multiple slots 18 respectively. When the multiple elastic claws 44 are outside the delivery sheath 3, the multiple elastic claws 44 separate radially from the multiple slots 18. Thus, when the pusher 6 pushes the connector 4 out of the delivery sheath 3, the radial force applied by the delivery sheath 3 is removed, thereby separating the connector 4 from the tissue harvesting scaffold 1.

[0094] Optionally, at least one of the puncture needle 2, delivery sheath 3, and first tightening wire 5 is provided with graduations. The outer surfaces of the puncture needle 2 and delivery sheath 3 may have graduations to help the physician determine the depth to which they have entered the tissue. The first tightening wire 5 may have graduations on the portion remaining outside the body to indicate to the physician the current degree of closure of the tissue harvesting scaffold 1.

[0095] The use of this minimally invasive interventional surgical instrument includes: Guided by imaging (such as CT), the puncture path leads to the target tissue. Alternatively, it can be accessed through natural cavities to reach the vicinity of the target tissue, followed by local puncture to approach the lesion.

[0096] After puncture, the delivery sheath 3 can be delivered into the patient's body through the puncture needle 2, or it can be re-entered through the puncture opening after the puncture needle 2 is withdrawn, making it possible to use a smaller diameter puncture needle 2.

[0097] The tissue harvesting scaffold 1 or 1' is pushed out of the delivery sheath 3 by the pusher 6. After self-expansion or the application of positive pressure, it will form a structure within the tissue. Figure 2 The expansion state is shown. The expansion process can be energized to reduce expansion resistance. Since the distal end of the tissue harvesting scaffold 1 leaves the delivery sheath 3, the distal end of the tissue harvesting scaffold 1 expands first. Energizing this distal end can give it a cutting function, allowing it to cut and expand simultaneously.

[0098] After the tissue harvesting stent 1 or 1' expands, it can continue to be pushed forward, and the diseased tissue can be drawn into the internal space of the tissue harvesting stent 1 or 1' through mechanical cutting and / or electro-cutting. Alternatively, it can be rotated while suction is applied to increase the intensity of mechanical cutting. During the cutting process, the aforementioned pneumatic device can continuously maintain a negative pressure state within the internal space, allowing more tissue to be drawn and fixed into the internal space. During tissue cutting, electro-cutting mode can be used alone, electrocoagulation mode can be used alone, or a combination of electro-cutting and electrocoagulation modes can be used to meet different cutting and hemostasis needs.

[0099] After the diseased tissue is brought into the content space, the first tightening wire 5 is pulled up. The length of the pull can be used to determine whether the tissue harvesting scaffold 1 or 1' has been completely retracted. Different electrosurgical modes such as electrocautery, electrocoagulation, or vascular closure can be performed continuously during the pulling process. After complete retraction, electroablation can be applied to inactivate any unharvested tissue in the area.

[0100] If the tissue is compressible, after it is fully compressed, the tissue harvesting scaffold 1 or 1' can be retracted into the delivery sheath 3 by pulling the pusher 6. This allows the tissue harvesting scaffold 1 or 1' to be completely encapsulated before being removed from the body, reducing the risk of implantation metastasis. Alternatively, the tissue harvesting scaffolds 1 and 1' can be fixed to the delivery sheath 3 and the pusher 6 and then pulled directly to remove all the tissue. Optionally, the puncture needle 2 can remain in the body for subsequent treatment, such as injecting hemostatic agents.

[0101] If the tissue harvesting stent 1 or 1' needs to be retained in the patient's body, the pusher 6 can be continued to be pushed out until the connector 4' is pushed out of the delivery sheath 3 and then unlocked. After retracting the puncture needle 2, delivery sheath 3, connector 4' and pusher 6, the tissue harvesting stent 1 or 1' and the first tightening wire 5 will remain in the body and will be removed in another surgery. If the tissue harvesting stent 1 or 1' is in self-degradable mode, the first tightening wire 5 can be extracted from the body by unlocking the tissue harvesting stent 1 or 1' from the first tightening wire 5, or the portion of the first tightening wire 5 remaining outside the stent can be cut off using a cutting device.

[0102] The present invention has been described through the above embodiments. However, it should be understood that the above embodiments are for illustrative purposes only and are not intended to limit the invention to the scope of the described embodiments. Furthermore, those skilled in the art will understand that the present invention is not limited to the above embodiments, and many more variations and modifications can be made based on the teachings of the present invention, all of which fall within the scope of protection claimed by the present invention. The scope of protection of the present invention is defined by the appended claims and their equivalents.

Claims

1. A tissue cutter, comprising: The tissue resection device comprises: a tissue resection stent comprising a fixed part, a support part and an expansion part, which are sequentially connected in an axial direction of the tissue resection stent from a proximal end to a distal end, wherein: the support part and the expansion part are radially expandable to form a content space in a shape of a gradually opened horn from the proximal end to the distal end; and the distal end of the expansion part is provided with a plurality of first threading holes arranged in a circumferential direction of the tissue resection stent; and a first tightening wire passing through the plurality of first threading holes, wherein: the first tightening wire is configured to be pulled to narrow the distal end of the expansion part so that the tissue resection stent is in a collapsed state; when the tissue resection stent is in the collapsed state, the expansion part is bent radially inward relative to the support part.

2. The tissue snare of claim 1, wherein, The expansion part and the support part are in a net structure as a whole.

3. The tissue snare of claim 1, wherein, The support part comprises a plurality of support segments arranged in the circumferential direction of the tissue resection stent, each of the plurality of support segments having a root end connected to the fixed part and a tip end connected to the expansion part.

4. The tissue snare of claim 3, wherein, The expansion part comprises a plurality of expansion segments arranged in the circumferential direction of the tissue resection stent, each of the expansion segments being V-shaped so as to have two open ends and a pointed end, the open ends are connected to the tip ends of the plurality of support segments one by one, and the pointed end of each of the expansion segments is provided with a first threading hole.

5. The tissue snare of claim 4, wherein, All the pointed ends of the expansion part are rotated by a predetermined angle in a plane perpendicular to the axial direction, so that the first threading holes are at the predetermined angle with the radial direction of the tissue resection stent.

6. The tissue snare of claim 3, wherein, Each of the plurality of support segments is in a rod shape, wherein, in the expanded support part, the plurality of support segments are radially arranged from the root end to the tip end.

7. The tissue snare of claim 3, wherein, In the expanded support part, each of the plurality of support segments is Y-shaped, so that each of the plurality of support segments comprises a root end and two tip ends, wherein the root ends of the plurality of support segments are gathered together, and in any two adjacent support segments, one tip end of one support segment is connected to one tip end of the other support segment.

8. The tissue snare of claim 1, wherein, The expansion part gradually opens from the proximal end to the distal end in a free state without external force.

9. The tissue snare of claim 8, wherein, The expansion part is bent radially outward relative to the support part in a free state without external force.

10. The tissue snare of claim 1, wherein, The support part is provided with a plurality of second threading holes arranged in the circumferential direction of the tissue resection stent, and the tissue resector further comprises a second tightening wire passing through the plurality of second threading holes.

11. The tissue snare of claim 10, wherein, The second tightening wire sequentially passes through the plurality of second threading holes in the circumferential direction.

12. The tissue resector according to claim 1, wherein: the fixed part, the support part and the expansion part are formed by cutting a pipe material in the axial direction; and / or the support part and the expansion part have a self-expanding function; and / or The proximal end of the tissue cutting stent has a central hole which is communicated to the inner space along the axial direction, and the end of the first tightening wire is led out from the inner space through the central hole.

13. The tissue snare of claim 1, wherein, The first tightening wire sequentially passes through the plurality of threading holes along the circumferential direction.

14. The tissue cutter according to claim 17, wherein The first tightening wire passes through the plurality of threading holes along the radial direction of the tissue cutting stent; and / or The first tightening wire passes through the plurality of threading holes alternately, so that the first tightening wire forms a mesh structure at the distal end of the expansion part.

15. The tissue snare of claim 1, wherein, The tissue cutting stent further comprises a film layer covering the support part and the expansion part.

16. The tissue snare of claim 15, wherein, The film layer comprises an inner film layer covering the inner surface of the support part and the expansion part, and / or an outer film layer covering the outer surface of the support part and the expansion part, the inner film layer being an insulating film layer, and the outer film layer being a conductive film layer or an insulating film layer.

17. A minimally invasive interventional surgical instrument, characterized by, The minimally invasive interventional surgical instrument comprises: The tissue cutter according to any one of claims 1-16; a delivery sheath, the tissue cutting stent in a contracted state being accommodated in the delivery sheath, the delivery sheath having a proximal opening at the proximal end thereof and a distal opening at the distal end thereof; a pusher; and a connector connected between the pusher and the proximal end of the tissue cutting stent, wherein the pusher extends into the delivery sheath from the proximal opening of the delivery sheath, and is used to push the tissue cutting stent out of the distal opening of the delivery sheath.

18. The minimally invasive interventional surgical instrument of claim 17, wherein, The connector comprises a plurality of elastic clamping claws, and the proximal end of the tissue cutting stent is provided with a plurality of clamping grooves on the outer side surface thereof, wherein when the connector is located in the delivery sheath, the plurality of elastic clamping claws are compressed in the radial direction, and the compressed plurality of elastic clamping claws are respectively clamped with the plurality of clamping grooves, when the plurality of elastic clamping claws are located outside the delivery sheath, the plurality of elastic clamping claws are separated from the plurality of clamping grooves in the radial direction.

19. The minimally invasive interventional surgical instrument of claim 17, wherein, The first tightening wire and the tissue cutting stent are conductive.

20. The minimally invasive interventional surgical instrument of claim 19, wherein, The delivery sheath is conductive, the outer surface of the tissue cutting stent is covered with an insulating outer film layer, and the connector and the pusher are insulated from the delivery sheath.

21. The minimally invasive interventional surgical instrument of claim 17, wherein, The distal end of the delivery sheath is provided with a water permeable hole, the tissue cutting stent is covered with a water-proof film layer, and the space between the water-proof film layer and the delivery sheath is communicated with the outside through the water permeable hole.

22. The minimally invasive interventional surgical instrument of claim 17, wherein, The minimally invasive interventional surgical instrument further comprises a puncture needle, and the delivery sheath is accommodated in the puncture needle.

23. The minimally invasive interventional surgical instrument according to claim 22, wherein The first tightening wire and the tissue cutting stent are conductive, the puncture needle is conductive, and the delivery sheath is insulating; and / or At least one of the puncture needle, the delivery sheath and the first tightening wire is provided with a scale.

24. The minimally invasive interventional surgical instrument of claim 17, wherein, In the case that the fixing part is provided with a through hole communicated with the central hole, the minimally invasive interventional surgical instrument further comprises a pneumatic device for inflating and / or deflating the delivery sheath.

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