Whitening and freckle-removing composition and skin cream prepared from whitening and freckle-removing composition

Abstract

The invention relates to the technical field of cosmetics, in particular to a whitening and freckle-removing composition and skin cream prepared from the same. The invention relates to a whitening and freckle-removing composition, which consists of an almond extract, a peach kernel extract, a ligusticum wallichii extract, an angelica sinensis extract and a scutellaria baicalensis root extract, and the mass ratio of the almond extract to the peach kernel extract is (1-3): (1-3). The mass ratio of the ligusticum wallichii and angelica sinensis extract to the scutellaria baicalensis root extract is (1-4): (1-4): 1. The whitening and freckle-removing composition can be applied to skin care cream or skin cream, not only has whitening and freckle-removing effects, but also is mild in property, safe and non-irritant.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of cosmetics, in particular to a whitening and freckle-removing composition and a skin cream and skin milk prepared therefrom. BACKGROUND

[0002] Silk white freckle ointment is a unique product of Nanjing Jinling Pharmaceutical Factory of Jinling Pharmaceutical Co., Ltd., and is one of the few external ointments for treating chloasma, and is included in the "Chloasma Expert Consensus on Traditional Chinese Medicine Treatment (2019 Edition)". It has the effects of activating blood and resolving stasis, dispelling wind and removing spots, and is suitable for chloasma caused by blood stasis and skin malnutrition. Chinese Patent CN100446801C discloses a freckle-removing ointment and its preparation method. The ointment base contains thirteen kinds of Chinese medicinal ingredients, including notoginseng, apricot kernel, peach kernel, yam, white radix angelica, prepared white aconite, loofah sponge, angelica, yarrow, white caterpillar fungus, white vine, radix scrophulariae, and chuanxiong. The preparation method is to extract the volatile oil of angelica and chuanxiong for standby, recover the ethanol filtrate of notoginseng, apricot kernel, peach kernel, yarrow, and yam for standby, and water decoct the filtrate of radix scrophulariae, white caterpillar fungus, prepared white aconite, and loofah sponge with the angelica and chuanxiong residue after volatile oil extraction, and then add the above extracted Chinese medicinal ingredients to the ointment base. The freckle-removing ointment is beneficial to improving the permeability of skin capillaries, promoting subcutaneous circulation, and has a strong inhibitory rate on tyrosinase, and has a significant effect on chloasma. However, the freckle-removing ointment has many components and a complex preparation process, and it is necessary to find a whitening and freckle-removing composition that can reduce components while still having freckle-removing effect, and can be used as the core to prepare special cosmetics such as mild, safe, and non-irritating milk or cream. SUMMARY

[0003] The present application aims to provide a whitening and freckle-removing composition that can be applied to skin milk or cream, has a whitening and freckle-removing effect, and is mild, safe, and non-irritating.

[0004] To achieve the object of the present application, the technical solutions are as follows:

[0005] A whitening and freckle-removing composition is composed of apricot kernel extract, peach kernel extract, chuanxiong extract, angelica extract, and radix scrophulariae extract.

[0006] Further, the mass ratio of apricot kernel extract to peach kernel extract is (1-3):(1-3); preferably, the mass ratio of apricot kernel extract to peach kernel extract is 1:1. The mass ratio of chuanxiong extract to angelica extract to radix scrophulariae extract is (1-4):(1-4):1. The mass ratio of chuanxiong extract to angelica extract to radix scrophulariae extract is (2-4):(2-4):1; more preferably, the mass ratio of chuanxiong extract to angelica extract to radix scrophulariae extract is 4:2:1.

[0007] Furthermore, the whitening and freckle-removing composition accounts for 0.026%-0.128% of the mass of the skin lotion or cream. Preferably, the whitening and freckle-removing composition accounts for 0.068%-0.1% of the mass of the skin lotion or cream. More preferably, the whitening and freckle-removing composition accounts for 0.084% of the mass of the skin lotion or cream.

[0008] The whitening and freckle-removing composition, in a skin lotion or cream, comprises the following components in the following mass percentages: almond extract 0.01%~0.05%; peach kernel extract 0.01%~0.05%; chuanxiong extract 0.002%~0.01%; angelica extract 0.002%~0.01%; and scutellaria root extract 0.002%~0.008%. Preferably, the whitening and freckle-removing composition, in a skin lotion or cream, comprises the following components in the following mass percentages: almond extract 0.02%~0.04%; peach kernel extract 0.02%~0.04%; chuanxiong extract 0.006%~0.01%; angelica extract 0.002%~0.006%; and scutellaria root extract 0.002%~0.004%. More preferably, in the skin care lotion or cream, the whitening and freckle-removing composition comprises the following components in the following mass percentages: almond extract 0.035%; peach kernel extract 0.035%; chuanxiong extract 0.008%; angelica extract 0.004%; and scutellaria root extract 0.002%.

[0009] A skin lotion comprising the whitening and spot-removing composition as described above, specifically as follows:

[0010] A1 phase raw materials: water, glycerol, butylene glycol, carbomer, xanthan gum, disodium EDTA (disodium EDTA).

[0011] B1 phase raw materials: cetearyl alcohol, isononyl isononanoate, glyceryl stearate citrate, polydimethylsiloxane, squalane, shea butter (BUTYROSPERMUM PARKII), ethylene glycol stearate, polydimethylsiloxane, tocopheryl acetate;

[0012] C1 phase raw materials: triethanolamine and water;

[0013] D1 phase raw materials: 1,3-propanediol, octyl glycol, ethylhexylglycerol, octyl hydroxamic acid;

[0014] E1 phase ingredients: 1,2-hexanediol, glycerin, butylene glycol, p-hydroxyacetophenone, ethylhexylglycerin, phenoxyethanol, panthenol, 3-o-ethyl ascorbic acid, dipotassium glycyrrhizate, raspberry ketone glucoside, ginsenosides and whitening and spot-removing composition.

[0015] Furthermore, the mass percentages of each component in the above-mentioned skincare lotion are as follows:

[0016] The mass percentages of the A1 phase raw material are: water 3.46%, glycerol 5%, butylene glycol 4%, carbomer 0.3%, xanthan gum 0.1%, and disodium ethylenediaminetetraacetate (EDTA-disodium) 0.05%.

[0017] The mass percentages of the B1 phase raw materials are as follows: cetearyl alcohol 1%, isononyl isononanoate 3%, glyceryl stearate citrate 2%, polydimethylsiloxane 2%, squalane 2%, shea butter (BUTYROSPERMUM PARKII) 1%, ethylene glycol stearate 0.7%, polydimethylsiloxane 2%, and tocopheryl acetate 0.5%;

[0018] The mass percentages of the D1 phase feedstock are: 1,3-propanediol 0.575%, octyl glycol 0.25%, ethylhexylglycerin 0.1%, and capryloyl hydroxamic acid 0.074%.

[0019] The mass percentages of the E1 phase raw materials are as follows: 1,2-hexanediol 0.024%, glycerin 0.18%, butylene glycol 2.15%, p-hydroxyacetophenone 0.01%, ethylhexylglycerin 0.0003%, phenoxyethanol 0.0027%, panthenol 0.5%, 3-o-ethyl ascorbic acid 1%, dipotassium glycyrrhizate 0.1%, raspberry ketone glucoside 0.5%, ginsenosides 0.02%, and whitening and freckle-removing composition 0.026%-0.128%.

[0020] The mass percentage of the C1 phase raw material is: triethanolamine 0.2%, water 67.076~67.178%.

[0021] Furthermore, the mass percentages of each component in the aforementioned skincare lotion are as follows:

[0022] The mass percentages of the A1 phase raw material are: water 3.46%, glycerol 5%, butylene glycol 4%, carbomer 0.3%, xanthan gum 0.1%, and disodium ethylenediaminetetraacetate (EDTA-disodium) 0.05%.

[0023] The mass percentages of the B1 phase raw materials are as follows: cetearyl alcohol 1%, isononyl isononanoate 3%, glyceryl stearate citrate 2%, polydimethylsiloxane 2%, squalane 2%, shea butter (BUTYROSPERMUM PARKII) 1%, ethylene glycol stearate 0.7%, polydimethylsiloxane 2%, and tocopheryl acetate 0.5%;

[0024] The mass percentages of the D1 phase feedstock are: 1,3-propanediol 0.575%, octyl glycol 0.25%, ethylhexylglycerin 0.1%, and capryloyl hydroxamic acid 0.074%.

[0025] The mass percentages of the E1 phase raw materials are as follows: 1,2-hexanediol 0.024%, glycerol 0.18%, butylene glycol 2.15%, p-hydroxyacetophenone 0.01%, ethylhexylglycerin 0.0003%, phenoxyethanol 0.0027%, panthenol 0.5%, 3-o-ethyl ascorbic acid 1%, dipotassium glycyrrhizate 0.1%, raspberry ketone glucoside 0.5%, ginsenosides 0.02%, almond extract 0.01%~0.05%; peach kernel extract 0.01%~0.05%; chuanxiong extract 0.002%~0.01%; angelica extract 0.002%~0.01%; scutellaria root extract 0.002%~0.008%.

[0026] The mass percentage of the C1 phase raw material is: triethanolamine 0.2%, water 67.076~67.178%.

[0027] The above-mentioned method for preparing a skin lotion includes the following steps:

[0028] S1. Add phase A1 to the main pot, heat to 75~85℃ while stirring, and stir thoroughly until completely dissolved;

[0029] S2. Add phase B1 to the oil pan, heat to 75~85℃ while stirring, and stir thoroughly until completely dissolved.

[0030] S3. Add phase B1 raw material to phase A1 raw material, turn on the main pot homogenization function, set the homogenization frequency to 45±2Hz, and homogenize for 3-5 minutes until the material is completely homogeneous.

[0031] S4. After cooling to 40-50℃, keep the temperature and add the C1 phase raw material into the main pot, then stir evenly.

[0032] S5. Keep the temperature at 40-50℃, add the D1 phase raw material into the main pot and stir evenly;

[0033] S6. Keep the temperature at 40-50℃, add the E1 phase raw material to the main pot, and stir evenly;

[0034] S7. Cool to room temperature (23±5℃) to obtain the product.

[0035] A skin cream comprising the whitening and spot-removing composition as described above, specifically as follows:

[0036] A2 phase ingredients: water, glycerol, butylene glycol, nicotinamide, hydroxyethyl acrylate copolymer with sodium acryloyl dimethyl taurate, trehalose, xanthan gum and disodium EDTA;

[0037] B2 phase raw materials: cetearyl alcohol, triglyceride decanoate, polyglycerol-3 stearate, hydrogenated coconut oil, shea butter, isononyl isononanoate, squalane, polydimethylsiloxane and tocopheryl acetate;

[0038] C2 phase raw materials: 1,3-propanediol, octyl glycol, ethylhexylglycerol and octyl hydroxamic acid;

[0039] D2 phase ingredients: water, p-hydroxyacetophenone, polyol mixture, hydroxypropyl cyclodextrin, potassium sorbate, phenoxyethanol, panthenol, glycyrrhizin, dipotassium glycyrrhizate, raspberry ketone glucoside, mandarin orange peel extract and whitening and spot-removing composition.

[0040] E2 phase raw materials: water and citric acid.

[0041] Furthermore, the polyol mixture in the D2 phase raw material of the skin cream is selected from two or more of butylene glycol, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, glycerin, and ethylhexylglycerin.

[0042] Furthermore, the mass percentages of each component in the skin cream are as follows:

[0043] The mass percentages of the A2 phase raw materials are: water 3.035%, glycerol 5%, butanediol 4%, nicotinamide 5%, hydroxyethyl acrylate and sodium acryloyl dimethyl taurate copolymer 1.1%, trehalose 1%, xanthan gum 0.1%, and disodium EDTA (ethylenediaminetetraacetic acid) 0.05%.

[0044] The mass percentages of the B2 phase raw materials are as follows: cetearyl alcohol 2.5%, triglyceride decanoate 0.8%, polyglycerol-3 stearate 0.5%, hydrogenated coconut oil 0.5%, shea butter (BUTYROSPERMUM PARKII) 2.3%, isononyl isononanoate 3%, squalane 3%, polydimethylsiloxane 2%, and tocopheryl acetate 0.5%.

[0045] The mass percentages of the C2 phase feedstock are: 1,3-propanediol 0.8625%, octyl glycol 0.375%, ethylhexylglycerin 0.15%, and capryloyl hydroxamic acid 0.1125%.

[0046] The mass percentages of the raw materials in phase D2 are as follows: water 58.18%, p-hydroxyacetophenone 0.01%, butylene glycol 0.18%, 1,3-propanediol 1%, 1,2-pentanediol 0.055%, 1,2-hexanediol 0.004%, glycerin 0.18%, ethylhexylglycerin 0.0004%, hydroxypropyl cyclodextrin 0.17%, potassium sorbate 0.001%, phenoxyethanol 0.0036%, panthenol 0.5%, glycyrrhizin 0.022%, dipotassium glycyrrhizate 0.1%, raspberry ketone glucoside 0.5%, mandarin orange peel extract 0.01~0.06%, and whitening and freckle-removing composition 0.026%-0.128%.

[0047] The mass percentages of the E2 phase raw materials are: water 3.521~3.673%, citric acid 0.06%. Furthermore, the mass percentages of each component in the skin cream are as follows:

[0048] The mass percentages of the A2 phase raw materials are: water 3.035%, glycerol 5%, butanediol 4%, nicotinamide 5%, hydroxyethyl acrylate and sodium acryloyl dimethyl taurate copolymer 1.1%, trehalose 1%, xanthan gum 0.1%, and disodium EDTA (ethylenediaminetetraacetic acid) 0.05%.

[0049] The mass percentages of the B2 phase raw materials are as follows: cetearyl alcohol 2.5%, triglyceride decanoate 0.8%, polyglycerol-3 stearate 0.5%, hydrogenated coconut oil 0.5%, shea butter (BUTYROSPERMUM PARKII) 2.3%, isononyl isononanoate 3%, squalane 3%, polydimethylsiloxane 2%, and tocopheryl acetate 0.5%.

[0050] The mass percentages of the C2 phase feedstock are: 1,3-propanediol 0.8625%, octyl glycol 0.375%, ethylhexylglycerin 0.15%, and capryloyl hydroxamic acid 0.1125%.

[0051] The mass percentages of the D2 phase raw materials are as follows: water 58.18%, p-hydroxyacetophenone 0.01%, butylene glycol 0.18%, 1,3-propanediol 1%, 1,2-pentanediol 0.055%, 1,2-hexanediol 0.004%, glycerol 0.18%, ethylhexylglycerol 0.0004%, hydroxypropyl cyclodextrin 0.17%, potassium sorbate 0.001%, phenoxyethanol 0.0036%, panthenol 0.5%, glycyrrhizin 0.022%, dipotassium glycyrrhizate 0.1%, raspberry ketone glucoside 0.5%, mandarin orange peel extract 0.01-0.06%, almond extract 0.01%-0.05%, peach kernel extract 0.01%-0.05%, chuanxiong extract 0.002%-0.01%, angelica extract 0.002%-0.01%, and scutellaria root extract 0.002-0.008%. ;

[0052] The mass percentage of the E2 phase raw material is: water 3.521~3.673%, citric acid 0.06%. Further, the preparation method of the above-mentioned skin cream composition includes the following steps:

[0053] Add phase A2 to the main pot, and heat to 75-85°C while stirring, stirring thoroughly until completely dissolved;

[0054] Add phase B2 to the oil pan, and heat to 75-85°C while stirring, stirring thoroughly until completely dissolved;

[0055] Add phase B2 raw material to phase A2 raw material, turn on the main pot homogenization function, set the homogenization frequency to 45±2Hz, and homogenize for 3-5 minutes until the material is completely homogeneous.

[0056] After cooling to 40-50℃, keep the temperature warm, add the C2 phase raw material to the main pot, and stir evenly;

[0057] Keep the temperature at 40-50℃, add the D2 phase raw material to the main pot, and stir well;

[0058] Maintain the temperature at 40-50℃, add the E2 phase raw material to the main pot, and stir well;

[0059] Cool to room temperature (23±5℃) to obtain the product.

[0060] Compared with existing technologies, the significant advantages of this invention are: the whitening and freckle-removing composition provided by this invention can significantly improve skin darkening and has obvious whitening and freckle-removing effects while reducing the original formula. When added to skin creams and lotions, the samples are mild, safe and non-irritating to the skin, and do not cause allergic reactions or phototoxicity. The skin creams or lotions are stable; after being placed under accelerated conditions (40℃ / RH75%) for 12 weeks, no significant changes in appearance were observed, and the results for microorganisms and heavy metals met the requirements, indicating good stability. Detailed Implementation

[0061] The technical solution of the present invention will be further described in detail through the following embodiments, but the embodiments should not be used to limit the scope of protection of the present invention. Any modifications and / or changes made to the invention will fall within the scope of protection of the present invention.

[0062] Almond extract, walnut kernel extract, chuanxiong extract, angelica extract, scutellaria extract, and Wenzhou mandarin peel extract were all purchased from the market.

[0063] Example 1: Preparation of Whitening and Spot-Removing Skin Lotion

[0064] This embodiment provides a whitening and freckle-removing skin lotion, the raw materials of which, according to parts by weight, include:

[0065] A1 phase raw materials: water 3.46%, glycerol 5%; butylene glycol 4%, carbomer 0.3%, xanthan gum 0.1%, disodium EDTA (disodium EDTA) 0.05%;

[0066] B1 phase raw materials: cetearyl alcohol 1%, isononyl isononanoate 3%, glyceryl stearate citrate 2%, polydimethylsiloxane 2%, squalane 2%, shea butter 1%, ethylene glycol stearate 0.7%, polydimethylsiloxane 2%, tocopheryl acetate 0.5%;

[0067] C1 phase raw materials: triethanolamine 0.2% or water 67.12%;

[0068] D1 phase raw materials: 1,3-propanediol 0.575%, octyl glycol 0.25%, ethylhexylglycerin 0.1%, capryloyl hydroxamic acid 0.074%;

[0069] E1 phase raw materials: 1,2-hexanediol 0.024%, glycerin 0.18%, butylene glycol 2.15%, p-hydroxyacetophenone 0.01%, ethylhexylglycerin 0.0003%, phenoxyethanol 0.0027%, panthenol 0.5%, 3-o-ethyl ascorbic acid 1%, dipotassium glycyrrhizate 0.1%, raspberry ketone glucoside 0.5%, ginsenosides 0.02%; almond extract 0.035%; peach kernel extract 0.035%; chuanxiong extract 0.008%; angelica extract 0.004%; scutellaria root extract 0.002%.

[0070] The preparation method of the whitening and freckle-removing skin lotion is as follows:

[0071] Add phase A1 to the main pot, heat to 80±5℃ while stirring, and stir thoroughly until completely dissolved;

[0072] Add phase B1 to the oil pan, heat to 80±5℃ while stirring, and stir thoroughly until completely dissolved;

[0073] Add phase B1 raw material to phase A1 raw material, turn on the emulsification pot homogenization function, set the homogenization frequency to 45±2Hz, and homogenize for 5 minutes until the material is completely homogeneous.

[0074] After cooling to 45±5℃, keep warm, add the C1 phase raw material into the main pot, and stir evenly;

[0075] Keep the temperature at 45±5℃, add the D1 phase raw material into the main pot, and stir well;

[0076] Keep the temperature at 45±5℃, add the E1 phase raw material to the main pot, and stir well;

[0077] Cool to room temperature (23±5℃), take samples for testing, and fill, package, and code after passing the inspection.

[0078] Example 2

[0079] Example 2: The formulation of the whitening and freckle-removing skin care lotion composition is basically the same as that of Example 1, except that the Coix Seed Extract is used instead of Ligusticum chuanxiong Extract in the D1 phase raw materials, and the preparation method is the same as that of Example 1.

[0080] Example 3

[0081] Example 3: The formulation of the whitening and freckle-removing skin care lotion composition is basically the same as that of Example 1, except that the mass percentages of Ligusticum chuanxiong extract, Angelica sinensis extract, and Scutellaria baicalensis root extract are changed from 0.008% Ligusticum chuanxiong extract, 0.004% Angelica sinensis extract, and 0.002% Scutellaria baicalensis root extract to 0.006% Ligusticum chuanxiong extract, 0.006% Angelica sinensis extract, and 0.002% Scutellaria baicalensis root extract. The preparation method is the same as that of Example 1.

[0082] Example 4

[0083] Example 4: The formulation of the whitening and freckle-removing skin care lotion composition is basically the same as that of Example 1, except that the mass percentages of Ligusticum chuanxiong extract, Angelica sinensis extract, and Scutellaria baicalensis root extract are changed. Instead of 0.008% Ligusticum chuanxiong extract, 0.004% Angelica sinensis extract, and 0.002% Scutellaria baicalensis root extract, the composition is changed to 0.002% Ligusticum chuanxiong extract, 0.008% Angelica sinensis extract, and 0.004% Scutellaria baicalensis root extract. The preparation method is the same as that of Example 1.

[0084] Example 5: Preparation of Whitening and Spot-Removing Skin Cream

[0085] This embodiment provides a whitening and freckle-removing skin cream, the raw materials of which, according to parts by weight, include:

[0086] A2 phase raw materials: water 3.035%; glycerol 5%; butylene glycol 4%; nicotinamide 5%; hydroxyethyl acrylate / sodium acryloyl dimethyl taurate copolymer 1.1%; trehalose 1%; xanthan gum 0.1%; disodium EDTA (ethylenediaminetetraacetic acid) 0.05%.

[0087] B2 phase ingredients: Cetearyl alcohol 2.5%; Triglyceride decanoate 0.8%; Polyglycerol-3 stearate 0.5%; Hydrogenated coconut oil 0.5%; Butyrospermum Parkii fruit oil 2.3%; Isonononyl isononanoate 3%; Squalane 3%; Polydimethylsiloxane 2%; Tocopheryl acetate 0.5%.

[0088] C2 phase raw materials: 1,3-propanediol 0.8625%; octyl glycol 0.375%; ethylhexylglycerin 0.15%; capryloyl hydroxamic acid 0.1125%.

[0089] D2 phase raw materials: Water 58.18%; p-hydroxyacetophenone 0.01%; butylene glycol 0.18%; 1,3-propanediol 1%; 1,2-pentanediol 0.055%; 1,2-hexanediol 0.004%; glycerol 0.18%; ethylhexylglycerol 0.0004%; hydroxypropyl cyclodextrin 0.17%; potassium sorbate 0.001%; ​​phenoxyethanol 0.0036%; panthenol 0.5%; glycyrrhizin 0.022%; dipotassium glycyrrhizate 0.1%; Satsuma mandarin orange peel extract 0.03%; almond extract 0.035%; peach kernel extract 0.035%; chuanxiong extract 0.008%; angelica extract 0.004%; scutellaria baicalensis root extract 0.002%; raspberry ketone glucoside 0.5%.

[0090] E2 phase raw materials: water 3.035%; citric acid 0.06%.

[0091] The preparation method of the whitening and freckle-removing skin cream is as follows:

[0092] Add phase A2 to the main pot, and heat to 80±5℃ while stirring, stirring thoroughly until completely dissolved;

[0093] Add phase B2 to the oil pan, heat to 80±5℃ while stirring, and stir thoroughly until completely dissolved;

[0094] Add phase B2 raw material to phase A2 raw material, turn on the main pot homogenization function, set the homogenization frequency to 45±2Hz, and homogenize for 5 minutes until the material is completely homogeneous.

[0095] After cooling to 45±5℃, keep warm, add the C2 phase raw material into the main pot, and stir evenly;

[0096] Keep the temperature at 45±5℃, add the D2 phase raw material into the main pot, and stir well;

[0097] Keep the temperature at 45±5℃, add the E2 phase raw material to the main pot, and stir well;

[0098] Cool to room temperature (23±5℃), take samples for testing, and fill, package, and code after passing the inspection.

[0099] Example 6

[0100] The formulation of the whitening and freckle-removing skin cream composition in Example 6 is basically the same as that in Example 5, except that the Coix Seed Extract is used instead of the Ligusticum chuanxiong Extract in the D2 phase raw material, and the preparation method is the same as that in Example 5.

[0101] Example 7

[0102] The formulation of the whitening and freckle-removing skin cream composition in Example 7 is basically the same as that in Example 5, except that the mass percentages of the extracts of Ligusticum chuanxiong, Angelica sinensis, and Scutellaria baicalensis roots are changed. The extract of Ligusticum chuanxiong 0.008%; the extract of Angelica sinensis 0.004%; the extract of Scutellaria baicalensis roots 0.002% are replaced with the extract of Ligusticum chuanxiong 0.006%; the extract of Angelica sinensis 0.006%; the extract of Scutellaria baicalensis roots 0.002%. The preparation method is the same as that in Example 5.

[0103] Example 8

[0104] The formulation of the whitening and freckle-removing skin cream composition in Example 8 is basically the same as that in Example 5, except that the mass percentages of the extracts of Ligusticum chuanxiong, Angelica sinensis, and Scutellaria baicalensis roots are changed. The extract of Ligusticum chuanxiong 0.008%; the extract of Angelica sinensis 0.004%; the extract of Scutellaria baicalensis roots 0.002% are replaced with the extract of Ligusticum chuanxiong 0.002%; the extract of Angelica sinensis 0.008%; the extract of Scutellaria baicalensis roots 0.004%. The preparation method is the same as that in Example 5.

[0105] Example 9 Repeated Skin Irritation Test

[0106] 1. Materials and Methods [[ID=1s4]]

[0107] 1.1 Test Substances: Samples of Examples 1-4 and Samples of Examples 5-8

[0108] 1.2 Experimental Animals

[0109] Species: Rabbit.

[0110] Strain: New Zealand Rabbit.

[0111] Level: Ordinary Level

[0112] Quantity: 4 in each test group. Female animals are selected as those that have not been pregnant and have not given birth.

[0113] Body Weight: 2.0 kg - 3.0 kg.

[0114] Source: Jiashan Jintu Rabbit Industry Professional Cooperative.

[0115] Experimental Animal Production License Number: SCXK (Zhe) 2020-0006.

[0116] Quality Certificate Number: 20250213Cezz06000000172.

[0117] 1.3 Feeding Environment

[0118] Temperature: 20°C - 26°C.

[0119] Relative Humidity: 40% - 70%.

[0120] License number for the use of experimental animal environment: SYXK (Shanghai) 2022 - 0005.

[0121] 1.4 Feed information

[0122] Feed source: Pizhou Xiaohe Technology Development Co., Ltd.

[0123] Feed certificate of conformity: QC2024113583291.

[0124] 2. Test methods

[0125] Before the test, the animals should be acclimated in the experimental animal house environment for at least 3 days. Approximately 24 hours before the test, clip the hair on both sides of the back spine of the experimental animals, taking care not to damage the epidermis. The hair removal area is 3 cm × 3 cm on each side (left and right). Take about 0.5 mL of the sample from the embodiment and apply it directly to one side of the skin. The application area is 2.5 cm × 2.5 cm. Apply deionized water to the other side as a control. Apply once a day for 14 consecutive days. Starting from the second day, clip the hair before each application and remove the residual test substance with deionized water. Observe the results one hour later and conduct skin reaction scoring according to Table 1 on Page 491 of the "Cosmetics Safety Technical Specifications" (2015 Edition) (hereinafter referred to as the Specifications). The control area and the test area are treated in the same way.

[0126] Table 1 Results of repeated skin irritation tests on rabbits in Example 1

[0127]

[0128] Table 2 Results of repeated skin irritation tests on rabbits in Example 2

[0129]

[0130] Table 3 Results of repeated skin irritation tests on rabbits in Example 3

[0131]

[0132] Table 4 Results of repeated skin irritation tests on rabbits in Example 4

[0133]

[0134] Table 5 Results of repeated skin irritation tests on rabbits in Example 5

[0135]

[0136] Table 6 Results of repeated skin irritation tests on rabbits in Example 6

[0137]

[0138] Table 7 Results of repeated skin irritation tests on rabbits in Example 7

[0139]

[0140] Table 8 Results of repeated skin irritation tests on rabbits in Example 8

[0141]

[0142] Experimental conclusions: Samples from Examples 1-3 showed no irritation to the skin of rabbits after repeated skin irritation; Sample 4 showed slight irritation after repeated skin irritation; Samples from Examples 5-7 showed no irritation to the skin of rabbits after repeated skin irritation; Sample 8 showed slight irritation after repeated skin irritation.

[0143] Example 10 Skin Allergic Reactions

[0144] 1. Materials and Methods

[0145] 1.1 Test substances: Samples from Examples 1-4 and Samples from Examples 5-8

[0146] 1.2. Positive substance name: 2,4-dinitrochlorobenzene.

[0147] Batch number: BCCJ4545. Manufacturer: Sigma-Aldrich.

[0148] Solvent: 80% ethanol

[0149] Inducing concentration: 1.0%.

[0150] Excitation concentration: 0.5%.

[0151] Dosage: 0.2 mL / animal.

[0152] 1.3 Laboratory Animals

[0153] Species: Guinea pig.

[0154] Strain: Hartley guinea pig.

[0155] Number: 20 animals in each experimental group, 20 animals in the positive control group, and 10 animals in the blank control group. Female animals were selected that were not pregnant and had never given birth.

[0156] Weight: 200g-300g.

[0157] Source: Jiashan County Jintu Rabbit Industry Professional Cooperative.

[0158] Laboratory animal production license number: SCXK (Zhejiang) 2020-0006.

[0159] Quality Certificate Number: 20250209Cddz06000000001

[0160] 1.4 Rearing Environment

[0161] Temperature: 20°C - 26°C.

[0162] Relative Humidity: 40% - 70%.

[0163] License Number for the Use of Experimental Animal Environment: SYXK (Shanghai) 2022 - 0005.

[0164] 1.5 Feed Information

[0165] Feed Source: Pizhou Xiaohe Technology Development Co., Ltd.,

[0166] Feed Qualification Certificates: QC20250102084706, QC20250102086820.

[0167] 2 Test Methods:

[0168] Before the test, the animals should be acclimated in the experimental animal house environment for at least 3d - 5d. The animals are randomly divided into the test substance group and the control group. The skin sensitization test of the test substance is carried out by the local closed skin painting method. Approximately 24h before the test, depilate the left side of the guinea pig's back, and the depilated area is 4cm 2 -6cm 2 .

[0169] Inductive Contact: Apply 0.2 mL of the test substance on the depilated area of the left side of the experimental animal's skin, cover it with two layers of gauze and one layer of cellophane, and then seal and fix it with non - irritating adhesive tape for 6h. The blank control group is treated in the same way after applying deionized water, and the positive control group is treated in the same way after applying the 2,4 - dinitrochlorobenzene solution at the inductive concentration. Repeat it once on the 7th day and the 14th day in the same way.

[0170] Challenge Contact: 14 days after the last induction, apply 0.2 mL of the test substance on the depilated area (depilated 24h before contact) of 2 cm × 2 cm on the right side of the guinea pig, then cover it with two layers of gauze and one layer of cellophane, and fix it with non - irritating adhesive tape for 6h. The blank control group is treated in the same way with the test substance in Example 1 during the challenge contact, and the positive control group is treated in the same way after applying the 2,4 - dinitrochlorobenzene solution at the challenge concentration.

[0171] Observe the skin reaction 24h and 48h after the challenge contact, and score according to Table 1 on Page 497 of the "Safety Technical Specification for Cosmetics" (2015 Edition) (hereinafter referred to as the Specification). When the skin reaction integral of the animals in the test substance group is ≥2, it is judged that the animal shows a positive skin sensitization reaction, and the sensitization intensity of the test substance is judged according to Table 3 on Pages 498 - 499 of the Specification.

[0172] Table 9 Experimental Information

[0173]

[0174] 3. Test Results

[0175] Table 10 Results of Guinea Pig Skin Allergy Test (BT Method)

[0176]

[0177]

[0178]

[0179] Note: In the column of skin reaction intensity, the proportion of the number of animals with reactions to the number of test animals should be filled in when the skin reaction scores are 0, 1, 2, 3...

[0180] Experimental Conclusion: The results of the guinea pig skin allergy test for the samples of Examples 1 - 8 were: no skin allergy was observed.

[0181] Example 11 Skin Phototoxicity Reaction

[0182] 1. Materials and Methods

[0183] 1.1 Test Substances: Samples of Examples 1 - 4 and Samples of Examples 5 - 8

[0184] Preparation Method: Use as original

[0185] 1.2 Experimental Animals

[0186] Species: Guinea pig.

[0187] Strain: Hartley guinea pig. <s

[0188] Grade: Ordinary grade.

[0189] Quantity: 6 in the test group (half male and half female), and female animals are selected as non-pregnant and non-littering

[0190] Body Weight: 200g - 300g.

[0191] Source: Jiashan Jintutu Industry Professional Cooperative

[0192] Experimental Animal Production License Number: SCXK (Zhe) 2020 - 0006

[0193] Quality Certificate Number: 20250206Cddz06000000010

[0194] 1.3 Feeding Environment

[0195] Temperature: 20℃-26℃.

[0196] Relative humidity: 40%-70%.

[0197] Laboratory Animal Environment Use Permit Number: SYXK (Shanghai) 2022-0005.

[0198] 1.4 Feed Information

[0199] Feed source: Pizhou Xiaohe Technology Development Co., Ltd.

[0200] Feed qualification certificate: QC20250102084706.

[0201] 1.5. Instruments

[0202] The manufacturer of the light source is Tianjin Economic-Technological Development Area Hepu Industry and Trade Co., Ltd.

[0203] Model: HOPE-MED 8130C.

[0204] 2. Experimental Methods

[0205] Average light intensity and exposure time:

[0206] Intensity Measurement: Before using the skin phototoxicity tester, the light intensity (mW / cm²) was measured at six points on the irradiated area of ​​the experimental animal's back, and the average value was taken. Under the experimental conditions, the average light intensity was approximately 5.625 mW / cm². 2

[0207] Calculation of irradiation time: Irradiation dose is 10 J / cm². 2 Calculate using the following formula:

[0208] Irradiation time (sec) = Irradiation dose (10000 mJ / cm²) 2 ) / Light intensity (mJ / cm 2 / sec), Under the conditions of this experiment, the irradiation time was 1778 seconds.

[0209] Animals should be allowed to acclimatize to the laboratory environment for at least 3-5 days before the experiment.

[0210] 18-24 hours before the formal phototoxicity test, remove hair from the skin on both sides of the animal's spine. The skin at the test site must be intact, without damage or abnormalities. Prepare 4 hair-removed areas according to Figure 1 on page 501 of the "Cosmetic Safety Technical Specifications" (2015 edition) (hereinafter referred to as the Specifications). Each hair-removed area is approximately 2cm × 2cm.

[0211] The animals were secured, and 0.2 mL of the test substance was applied to hairless areas 1 and 2 as shown in Table 1 of specification P501. After 30 min, the left side (hairless areas 1 and 3) was covered with aluminum foil and secured with tape, while the right side (hairless areas 2 and 4) was irradiated with UVA. Skin reactions were observed at 1, 24, 48, and 72 h after the procedure, and the skin reaction score for each animal was determined according to Table 2 of specification P501-P502. If no skin reaction was observed in the unirradiated areas after applying the test substance, but one or more animals showed a skin reaction score of 2 or higher in the irradiated areas after applying the test substance, the test substance was considered to be phototoxic.

[0212] Table 11 Results of phototoxicity test on guinea pig skin in Example 1

[0213]

[0214] Table 12 Results of phototoxicity test on guinea pig skin in Example 2

[0215]

[0216] Table 13 Results of phototoxicity test on guinea pig skin in Example 3

[0217]

[0218] Table 14 Results of phototoxicity test on guinea pig skin in Example 4

[0219]

[0220] Table 15 Results of phototoxicity test on guinea pig skin in Example 5

[0221]

[0222] Table 16 Results of phototoxicity test on guinea pig skin in Example 6

[0223]

[0224] Table 17 Results of phototoxicity test on guinea pig skin in Example 7

[0225]

[0226] Table 18 Results of phototoxicity test on guinea pig skin in Example 8

[0227]

[0228] Experimental conclusions: No skin phototoxicity was observed in Examples 1, 3, and 4; Example 2 exhibited some skin phototoxicity. No skin phototoxicity was observed in Examples 5, 7, and 8; Example 6 exhibited some skin phototoxicity.

[0229] Example 12: Detection of Skin Whitening and Spot Removal Using an Ultraviolet-Induced Human Skin Melanization Model

[0230] 1. Materials and Methods

[0231] 1.1 Test substances: Samples from Example 1 and Example 5

[0232] Blank comparison: Blank comparison of the blackened area

[0233] Positive control: 7% ascorbic acid (vitamin C) product (refrigerated at 4°C, stored in aluminum tube away from light).

[0234] 1.2. Light source: Xenon arc lamp of daylight simulator, all performance indicators meet the requirements of the testing specifications.

[0235] 1.3. Instrument: Equipped with instruments capable of measuring L*a*b* color space data as defined by the International Commission on Illumination (CIE), and all performance indicators meet the requirements of the measurement specifications.

[0236] An instrument that measures skin MI values ​​based on the principle of spectral absorption.

[0237] 1.4. A total of 30 subjects were included in Example 1, including 21 males and 9 females, aged 22 to 48 years, with a mean age of 34.6 ± 7.4 years, meeting the subject voluntary inclusion criteria. A total of 30 subjects were included in Example 5, including 21 males and 9 females, aged 22 to 48 years, with a mean age of 34.6 ± 7.4 years, meeting the subject voluntary inclusion criteria.

[0238] 1.5. Environmental conditions: Visual assessment and instrument testing should be conducted in an environment with a temperature of 21±1℃ and a relative humidity of 50±10% RH. Visual assessment should also be conducted under constant lighting conditions (fluorescent tubes or LED lights with a color temperature of 5500-6500K). Subjects should adapt to these environmental conditions for at least 30 minutes before assessment and testing can be performed.

[0239] 1.6. Testing Method: The test was conducted in accordance with the specific requirements of Chapter 8.5 of the 2015 edition of the "Cosmetic Safety Technical Specifications" (Test Method for Whitening and Spot-Removing Efficacy of Cosmetics (Method 1: Ultraviolet-Induced Human Skin Melanization Model Whitening and Spot-Removing Efficacy Test Method)). The test sites of the subjects were screened, with ITA° values ​​between 20° and 41°.

[0240] Qualified subjects enter the stage of establishing a human skin melanization model: First, the MED of each subject's test site should be determined. Then, each test area is selected at the test site, and a sunlight simulator is used to irradiate the same irradiation point once a day at a dose of 0.75 times the MED, for 4 consecutive days. The 4 days after the end of irradiation are the skin melanization period, during which no treatment is performed.

[0241] On the 5th day after the irradiation ended, the skin of each test area was visually evaluated and detected by a skin color instrument. Test areas with poor consistency (areas where the ITA° value differed from the average value of all test areas by more than 5) should be excluded. Starting from that day, the corresponding test substances were applied to each melanized test area according to the random table. The test substances were continuously applied for at least 4 weeks. The skin color should be visually evaluated and detected by the instrument at 1 week, 2 weeks, 3 weeks, and 4 weeks after application, and the results should be recorded.

[0242] 1.7 Statistical methods

[0243] Statistical analysis of the data was performed using statistical analysis software. Measurement data were expressed as mean ± standard deviation, and a normal distribution test was conducted. If it met the requirements of normal distribution, paired t-tests were used for comparison before and after; otherwise, the Wilcoxon signed-rank test for two related samples was used. For ordinal data, the Wilcoxon signed-rank test for two related samples was used for comparison before and after. For comparison between the test area and the control area, independent sample t-tests or the Wilcoxon rank-sum test were used. At the same time, the regression coefficient (slope K value) of each parameter changing over time was calculated, and the significance level was P < 0.05.

[0244] If the difference in ITA° value and the difference in MI value at any time point before and after the application of the test product were significantly improved compared with the negative control (P < 0.05), or if it was determined through regression coefficient analysis that the skin melanization of the test product was significantly improved compared with the negative control (P < 0.05), then the test product was considered to have the efficacy of freckle removal and skin whitening; otherwise, the test product was considered to have no such efficacy.

[0245] 2. Test results

[0246] Table 19 Results of the difference in ITA° value of skin color in each test area before and after the use of Example 1 (mean ± standard deviation)

[0247]

[0248] Note: Independent sample t-tests (or the Wilcoxon rank-sum test) were used for statistical analysis. Compared with the negative control, * indicates 0.01 < p < 0.05; ** indicates 0.001 < p < 0.01; *** indicates p < 0.001.

[0249] Table 20 Results of the regression coefficient (slope k value) of the skin ITA° value in Example 1 (mean + standard deviation)

[0250]

[0251] Note: Independent sample t-tests (or the Wilcoxon rank-sum test) were used for statistical analysis. Compared with the negative control, * indicates 0.01 < p <

[0252] Table 21 Skin MI difference value before and after the use of Example 1 (mean ± standard deviation)

[0253]

[0254] Note: Independent-sample t-test (or rank sum test) was used for statistical analysis. Compared with the negative control, * indicates 0.01 < p < 0.05; ** indicates 0.001 < p < 0.01; *** indicates p < 0.001.

[0255] Table 22 Analysis results of the regression coefficient (slope k value) of the skin MI value in Example 1 (mean ± standard deviation)

[0256]

[0257] Note: Independent-sample t-test (or rank sum test) was used for statistical analysis. Compared with the negative control, * indicates 0.01 < p < 0.05; ** indicates 0.001 < p < 0.01; *** indicates p < 0.001.

[0258] Table 23 Results of the difference in skin ITA° value in each test area before and after the use of Example 5 (mean ± standard deviation)

[0259] Note: Independent-sample t-test was used for statistical analysis. Compared with the negative control, * indicates 0.01 < p < 0.05; ** indicates 0.001 < p < 0.01; *** indicates p < 0.001.

[0260] Table 24 Results of the regression coefficient (slope k value) of the skin ITA° value in Example 5 (mean + standard deviation)

[0261]

[0262] Note: Independent-sample t-test was used for statistical analysis. Compared with the negative control, * indicates 0.01 < p < 0.05; ** indicates 0.001 < p < 0.01; *** indicates p < 0.001.

[0263] Table 25 Skin MI difference value before and after the use of Example 5 (mean ± standard deviation)

[0264]

[0265] Note: Independent-sample t-test was used for statistical analysis. Compared with the negative control, * indicates 0.01 < p < 0.05; ** indicates 0.001 < p < 0.01; *** indicates p < 0.001.

[0266] Table 26 Analysis Results of Skin MI Value Regression Coefficient (Slope k Value) in Example 5 (Mean ± Standard Deviation)

[0267]

[0268] Note: Independent-sample t-test (or rank sum test) was used for statistical analysis. Compared with the negative control, * indicates 0.01 < p < 0.05; ** indicates 0.001 < p < 0.01; *** indicates p < 0.001.

[0269] 3. Experimental Conclusions

[0270] Tables 19 and 20 show that the difference in skin ITA° at the first, second, third, and fourth weeks after using the product of Example 1 was significantly improved compared with the negative control (P < 0.05); the regression coefficient of skin ITA value (slope k value) showed significant improvement in skin darkening compared with the negative control (P < 0.05). Tables 21 and 22 show that the difference in skin MI at the first, second, third, and fourth weeks after using the product of Example 1 was significantly improved compared with the negative control (P < 0.05); the regression coefficient of skin MI value (slope k value) showed significant improvement in skin darkening compared with the negative control (P < 0.05), indicating that the product has the effect of removing freckles and whitening the skin.

[0271] Tables 23 and 24 show that the difference in skin ITA° at the first, second, third, and fourth weeks after using the product of Example 1 was significantly improved compared with the negative control (P < 0.05); the regression coefficient of skin ITA value (slope k value) showed significant improvement in skin darkening compared with the negative control (P < 0.05). Tables 25 and 26 show that the difference in skin MI at the first, second, third, and fourth weeks after using the product of Example 1 was significantly improved compared with the negative control (P < 0.05); the regression coefficient of skin MI value (slope k value) showed significant improvement in skin darkening compared with the negative control (P < 0.05), indicating that the product has the effect of removing freckles and whitening the skin.

[0272] Example 13 Stability Study

[0273] The samples of Example 1 and 5 were placed under the accelerated test conditions (40°C / RH75%) for stability study, and the results are shown in Tables 27 and 28.

[0274] Table 27 Results of Stability Study of Example 1 (40°C / RH75%)

[0275]

[0276] Table 28 Results of Stability Study of Example 5 (40°C / RH75%)

[0277]

[0278] Conclusion: The samples of Examples 1 and 5 underwent a 12-week accelerated stability test in accordance with the "Technical Guidelines for Stability Testing and Evaluation of Cosmetics", "Technical Specifications for Cosmetic Safety (2015 Edition)" and GB / T29665-2013 standards. No significant changes in appearance were found, and the results for microorganisms and heavy metals met the requirements, indicating good stability.

Claims

1. A skin whitening and freckle-removing composition, characterized by comprising: The whitening and freckle-removing composition is composed of almond extract, peach kernel extract, chuanqiong extract, angelica extract and radix scrophulariae extract. ​ 2. The whitening and freckle-removing composition according to claim 1, characterized by: The mass ratio of the almond extract and the peach kernel extract is (1-3):(1-3); the mass ratio of the chuanqiong extract and the angelica extract and the radix scrophulariae extract is (1-4):(1-4):

1.

3. The whitening and freckle-removing composition according to claim 2, characterized by: The mass ratio of the almond extract and the peach kernel extract is 1:1; the mass ratio of the chuanqiong extract, the angelica extract and the radix scrophulariae extract is (2-4):(2-4):

1.

4. The whitening and freckle-removing composition according to claim 3, characterized by: The mass ratio of the whitening and freckle-removing composition in the skin care milk or cream is 0.026%-0.128%.

5. The whitening and freckle-removing composition according to claim 3, characterized by: The mass ratio of each component in the whitening and freckle-removing composition in the skin care milk or cream is as follows: the almond extract is 0.01%-0.05%; the peach kernel extract is 0.01%-0.05%; the chuanqiong extract is 0.002%-0.01%; the angelica extract is 0.002%-0.01%; and the radix scrophulariae extract is 0.002-0.008%.

6. The whitening and freckle-removing composition according to claim 3, characterized by: The mass ratio of each component in the whitening and freckle-removing composition in the skin care milk or cream is as follows: the almond extract is 0.02%-0.04%; the peach kernel extract is 0.02%-0.04%; the chuanqiong extract is 0.006%-0.01%; the angelica extract is 0.002%-0.006%; and the radix scrophulariae extract is 0.002-0.004%.

7. A skin care cream, characterized by: The whitening and freckle-removing composition comprises the following components: A1 phase raw materials: water, glycerol, butanediol, carbomer, xanthan gum, disodium EDTA; B1 phase raw materials: cetyl stearyl alcohol, isononyl isononanoate, glyceryl stearate citrate, dimethicone, squalane, butyrospermum parkii butter, ethylene glycol stearate, dimethicone, tocopheryl acetate; C1 phase raw materials: triethanolamine and water; D1 phase raw materials: 1,3-propanediol, caprylyl glycol, ethylhexylglycerin, capryloyl oxyhydroxamic acid; E1 phase raw materials: 1,2-hexanediol, glycerol, butanediol, p-hydroxyacetophenone, ethylhexylglycerin, phenoxyethanol, panthenol, 3-o-ethyl ascorbic acid, dipotassium glycyrrhizate, raspberry ketone glucoside, ginsenoside and the whitening and freckle-removing composition. The whitening and freckle-removing composition comprises the following components: A2 phase raw materials: water, glycerol, butanediol, nicotinamide, hydroxyethyl acrylate and sodium acryloyldimethyl taurate copolymer, trehalose, xanthan gum and disodium EDTA; B2 phase raw materials: cetyl stearyl alcohol, capric triglyceride, polyglyceryl-3 stearate, hydrogenated coconut oil, butyrospermum parkii butter, isononyl isononanoate, squalane, dimethicone and tocopheryl acetate; C2 phase raw materials: 1,3-propanediol, caprylyl glycol, ethylhexylglycerin and capryloyl oxyhydroxamic acid; ​ ​ 8. A skin cream characterized by: ​ ​ ​ D2 phase raw materials: water, p-hydroxyacetophenone, polyol mixture, hydroxypropyl cyclodextrin, potassium sorbate, phenoxyethanol, panthenol, glabridin, glycyrrhizic acid dipotassium, raspberry ketone glucoside, mandarin peel extract and whitening and freckle-removing composition; E2 phase raw materials: water and citric acid.

9. A method of preparing a skin cream characterized in that: The skin care cream is selected from the skin care cream of claim 8, and the preparation method comprises the following steps: S1, A1 phase is added to the main pot, heated to 75-85°C while stirring, and fully stirred until completely dissolved; S2, B1 phase is added to the oil pot, heated to 75-85°C while stirring, and fully stirred until completely dissolved; S3, B1 phase raw materials are added to A1 phase raw materials, the homogenization function of the main pot is turned on, the homogenization frequency is set to 45±2Hz, and homogenization is performed for 3-5min until the material body is completely uniform; S4, after cooling to 40-50°C, C1 phase raw materials are added to the main pot and stirred uniformly; S5, after keeping the temperature at 40-50°C, D1 phase raw materials are added to the main pot and stirred uniformly; S6, after keeping the temperature at 40-50°C, E1 phase raw materials are added to the main pot and stirred uniformly; S7, cool to room temperature 23±5°C, and obtain.

10. A method of preparing a skin cream, characterized by: The skin care cream is selected from the skin care cream of claim 8, and the preparation method comprises the following steps: A2 phase is added to the main pot, heated to 75-85°C while stirring, and fully stirred until completely dissolved; B2 phase is added to the oil pot, heated to 75-85°C while stirring, and fully stirred until completely dissolved; B2 phase raw materials are added to A2 phase raw materials, the homogenization function of the main pot is turned on, the homogenization frequency is set to 45±2Hz, and homogenization is performed for 3-5min until the material body is completely uniform; S4, after cooling to 40-50°C, C2 phase raw materials are added to the main pot and stirred uniformly; S5, after keeping the temperature at 40-50°C, D2 phase raw materials are added to the main pot and stirred uniformly; S6, after keeping the temperature at 40-50°C, E2 phase raw materials are added to the main pot and stirred uniformly; S7, cool to room temperature 23±5°C, and obtain.

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