Traditional Chinese medicine composition for treating acute kidney injury and preparation method thereof

Abstract

The invention relates to a traditional Chinese medicine composition for treating acute kidney injury and a preparation method, and belongs to the technical field of traditional Chinese medicine preparation. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 10-30 parts of raw radix astragali; 10-15 parts of codonopsis pilosula; 10 parts of rhizoma pinellinae praeparata; 10 parts of pericarpium citri reticulatae; 15 to 30 parts of loofah sponge; 15 to 30 parts of serissa japonica; and 15-30 parts of rhizoma smilacis glabrae. The traditional Chinese medicine composition disclosed by the invention has two treatment methods of tonifying qi and relieving turbidity, realizes multiple ways, treats both symptoms and root causes, is promoted to be new, has the functions of tonifying qi and relieving turbidity, has a remarkable clinical effect on treating acute renal insufficiency, and has a very good effect in the aspects of improving renal functions and protecting kidneys.

Description

TECHNICAL FIELD

[0001] The present application relates to a traditional Chinese medicine composition for treating acute kidney injury and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine pharmacy. BACKGROUND

[0002] Acute kidney injury (AKI) refers to an increase of serum creatinine by at least 0.3 mg / dl within 48 hours, an increase of SCr to ≥1.5 times the baseline within the past 7 days, and urine output <0.5 ml / kg / h for 6 hours. Factors such as hypotension, ischemia, infection, exposure to nephrotoxic substances, or urinary tract obstruction can cause a decrease in renal blood flow, renal dysfunction, and an increase in serum urea nitrogen (BUN) and creatinine (Scr) levels, resulting in acute kidney injury.

[0003] According to statistics, 7% of hospitalized patients and 67% of ICU patients will eventually develop acute kidney injury and other organ dysfunction. The treatment options for AKI are very limited in clinical practice. The main treatment strategies focus on etiological treatment (such as controlling infection, restoring blood volume, and stopping the use of nephrotoxic drugs), maintaining water and electrolyte balance and acid-base balance, and using renal replacement therapy (such as hemodialysis and peritoneal dialysis) when necessary. Currently, there is no effective clinical drug for treating acute kidney injury. Based on this, the present application provides a traditional Chinese medicine composition for treating acute kidney injury and a preparation method thereof. SUMMARY

[0004] Therefore, the present application provides a traditional Chinese medicine composition for treating acute kidney injury and a preparation method thereof, which is innovative and has the functions of tonifying qi and removing turbidity. The clinical effect of the composition in treating acute renal insufficiency is remarkable, and the composition has a very good effect on improving renal function and protecting the kidneys.

[0005] The present application provides a traditional Chinese medicine composition for treating acute kidney injury, which is prepared from the following raw medicinal materials by weight: Radix Astragali 10-30 parts, Radix Codonopsis 10-15 parts, Rhizoma Pinelliae 10 parts, Pericarpium Citri Reticulatae 10 parts, Luffa operculata 15-30 parts, Herba Hyperici 15-30 parts, and Smilax glabra 15-30 parts.

[0006] Further, a traditional Chinese medicine composition for treating acute kidney injury is prepared from the following raw medicinal materials by weight: Radix Astragali 20 parts, Radix Codonopsis 12 parts, Rhizoma Pinelliae 10 parts, Pericarpium Citri Reticulatae 10 parts, Luffa operculata 20 parts, Herba Hyperici 20 parts, and Smilax glabra 20 parts.

[0007] Further, the traditional Chinese medicine composition is prepared into any dosage form acceptable in clinic.

[0008] Further, the dosage form is a decoction, granules, capsules, tablets, pills, or oral liquid.

[0009] Further, a preparation method of a traditional Chinese medicine composition for treating acute kidney injury comprises the following steps: (1) The raw materials of Radix Astragali, Radix Codonopsis, Rhizoma Pinelliae, Pericarpium Citri Reticulatae, Luffa, Radix Trichosanthis, and Smilax Glabra are weighed by parts; (2) All the weighed raw materials are mixed and placed in an extraction tank, 8-12 times the amount of water of the total weight of the raw materials is added, after soaking, the first decoction is carried out, after heating to boiling, a slight boiling state is maintained for a period of time, filtration is carried out, and the filtrate is collected; (3) In the dregs of step (2), 6-10 times the amount of water of the total weight of the raw materials is added, the second decoction is carried out, after heating to boiling, a slight boiling state is maintained for a period of time, filtration is carried out, and the filtrate is collected; (4) The two filtrates are combined, after standing and precipitating, the supernatant is taken, concentration is carried out, the supernatant is concentrated under the condition of 60-70℃, and the extract is obtained, which has a relative density of 1.10-1.25 measured at 60℃; (5) The extract is dried and crushed, and the traditional Chinese medicine composition for treating acute kidney injury is obtained.

[0010] Further, the soaking time in step (2) is 20-40 minutes, and the slight boiling state is maintained for 1-2 hours.

[0011] Further, in step (3), the slight boiling state is maintained for 1-1.5 hours.

[0012] Further, the drying treatment in step (5) is spray drying or vacuum reduced pressure drying.

[0013] The beneficial effects of the present application are: The present prescription combines the two treatment methods of tonifying qi and removing turbidity, and has the functions of tonifying qi and removing turbidity, and the clinical effect of treating acute renal failure is remarkable, and the effect of improving renal function and protecting the kidney is very good. DETAILED DESCRIPTION

[0014] The preferred embodiments of the present application will be described in detail below.

[0015] The present application provides a traditional Chinese medicine composition for treating acute kidney injury, which is made of the following raw materials by weight: Radix Astragali 10-30 parts; Radix Codonopsis 10-15 parts; Rhizoma Pinelliae 10 parts; Pericarpium Citri Reticulatae 10 parts; Luffa 15-30 parts; Radix Trichosanthis 15-30 parts; and Smilax Glabra 15-30 parts.

[0016] As an optional embodiment, a traditional Chinese medicine composition for treating acute kidney injury is prepared from the following raw medicinal materials by weight: Radix Astragali 20 parts; Codonopsis 12 parts; Rhizoma Pinelliae 10 parts; Pericarpium Citri Reticulatae 10 parts; Luffa 20 parts; Herba Hyperici 20 parts; Smilax 20 parts.

[0017] As an optional embodiment, the traditional Chinese medicine composition is prepared into any dosage form acceptable in clinic.

[0018] As an optional embodiment, the dosage form is decoction, granules, capsules, tablets, pills or oral liquid.

[0019] As an optional embodiment, a preparation method of a traditional Chinese medicine composition for treating acute kidney injury comprises the following steps: (1) Take Radix Astragali 20 kg, Codonopsis 12 kg, Rhizoma Pinelliae 10 kg, Pericarpium Citri Reticulatae 10 kg, Luffa 20 kg, Herba Hyperici 20 kg, and Smilax 20 kg of each raw medicinal material by weight; (2) Mix all the weighed raw medicinal materials and place them in an extraction tank, add 8-12 times the amount of water based on the total weight of the raw medicinal materials, soak for 20-40 minutes, then perform the first decoction, heat to boiling and maintain a state of slight boiling for 1-2 hours, filter, and collect the filtrate; (3) Add 6-10 times the amount of water based on the total weight of the raw medicinal materials to the residue of step (2), perform the second decoction, heat to boiling and maintain a state of slight boiling for 1-1.5 hours, filter, and collect the filtrate; (4) Combine the two filtrates, let them stand to precipitate, take the supernatant, concentrate, and reduce the pressure to concentrate the supernatant at 60-70°C to obtain an extract with a relative density of 1.10-1.25 measured at 60°C; (5) Dry the extract, which can be done by spray drying or vacuum reduced pressure drying, crush, pass the dry extract powder through a 100-mesh sieve, mix uniformly, and package, to obtain the product.

[0020] As an optional embodiment, a preparation method of a traditional Chinese medicine composition for treating acute kidney injury comprises the following steps: (1) Take Radix Astragali 20 kg, Codonopsis 12 kg, Rhizoma Pinelliae 10 kg, Pericarpium Citri Reticulatae 10 kg, Luffa 20 kg, Herba Hyperici 20 kg, and Smilax 20 kg of each raw medicinal material by weight; (2) Mix all the weighed raw medicinal materials and place them in an extraction tank, add 8-12 times the amount of water based on the total weight of the raw medicinal materials, soak for 20-40 minutes, then perform the first decoction, heat to boiling and maintain a state of slight boiling for 1-2 hours, filter, and collect the filtrate; (3) to the residue of step (2) add 6-10 times the total weight of the raw material water, second decoction, heating to boiling and keep the state of micro-boiling for 1-1.5 hours, filtration, collection of filtrate; (4) combined two filtrates, after standing, take the supernatant, concentrated, the supernatant at 60-70 DEG C under the condition of reduced pressure concentration, get in 60 DEG C under the condition of relative density of 1.10-1.25 extract; (5) the extract is dried, can use spray drying or vacuum drying, crushing, dry extract powder through 100 mesh sieve, mix evenly, sub-pack, get.

[0021] The application has the advantages of combination innovation, strict compatibility and sufficient theoretical basis: based on the deep understanding of the etiology and pathogenesis of acute kidney injury in TCM, the core pathogenesis is considered as deficiency in origin and excess in superficiality, that is, deficiency of spleen and kidney, and accumulation of dampness, blood stasis and toxic evil, the application takes tonifying qi as the origin, and considers dampness and detoxification, achieving the organic combination of supporting healthy qi and eliminating evil.

[0022] The monarch drug: heavy use of raw astragalus and radix codonopsis. Raw astragalus greatly tonifies the qi of spleen and lung, removes water and swelling, and promotes toxin discharge and skin granulation; Radix codonopsis strengthens the spleen and replenishes qi and blood, and the two drugs are used together as the monarch drug, which greatly tonifies the primordial qi, protects the spleen and kidney, supports healthy qi to resist evil, and provides the fundamental power for the recovery of kidney function. The minister drug: selected from smilax glabra, radix ophiopogonis and luffa, smilax glabra is sweet and bland, which can detoxify, remove dampness, and benefit joints, radix ophiopogonis clears heat and removes dampness, and soothes the liver and relieves depression, and luffa unblocks channels and collaterals, clears heat and resolves phlegm, the three drugs are used together as the minister drug, which mainly undertakes the function of removing dampness, and effectively removes the pathological products such as dampness, heat and toxin accumulated in the body due to kidney failure, and improves the microcirculation of the kidney. The assistant drug: selected from pinellia ternate and dried tangerine or orange peel, which are the main drugs of Erchen decoction, regulating qi, drying dampness and resolving phlegm, and strengthening the spleen and stomach, in the formula, they can assist the monarch drug in strengthening the spleen and replenishing qi, and enhance the effect of the minister drug in removing dampness and removing dampness, preventing the tonifying products from being greasy and hindering the stomach, and playing the role of regulating the middle jiao and transporting water and dampness.

[0023] The two methods of tonifying qi and removing dampness in the formula are used together, which treats the root and branch, and pushes out the old to bring forth the new, has the functions of tonifying qi and removing dampness, and has remarkable clinical effect in the treatment of acute renal insufficiency, and achieves good results in improving kidney function and protecting the kidney.

[0024] The above describes the application and its embodiments, which is not limited, and the actual structure is not limited. In general, if the ordinary skilled person in the art is inspired, without departing from the purpose of the application, without creative design, similar structure and embodiments of the technical solution should belong to the protection scope of the application.

Claims

1. A traditional Chinese medicine composition for treating acute kidney injury, characterized in that: The raw medicinal materials are prepared by weight parts: Radix Astragali 10-30 parts; Codonopsis 10-15 parts; Rhizoma Pinelliae 10 parts; Pericarpium Citri Reticulatae 10 parts; Luffa 15-30 parts; Herba Reineckiae 15-30 parts; Smilax 15-30 parts. ​ 2. The traditional Chinese medicine composition for treating acute kidney injury according to claim 1, characterized in that: The raw medicinal materials are prepared by weight parts: Radix Astragali 20 parts; Codonopsis 12 parts; Rhizoma Pinelliae 10 parts; Pericarpium Citri Reticulatae 10 parts; Luffa 20 parts; Herba Reineckiae 20 parts; Smilax 20 parts. 3.The traditional Chinese medicine composition for treating acute kidney injury according to claim 1 or 2, characterized in that: The traditional Chinese medicine composition is prepared into any dosage form acceptable in clinic.

4. The traditional Chinese medicine composition for treating acute kidney injury according to claim 3, characterized in that: The dosage form is decoction, granules, capsules, tablets, pills or oral liquid.

5. The preparation method of the traditional Chinese medicine composition for treating acute kidney injury according to any one of claims 1 to 4, characterized in that: The steps include: (1) The raw medicinal materials of Radix Astragali, Codonopsis, Rhizoma Pinelliae, Pericarpium Citri Reticulatae, Luffa, Herba Reineckiae and Smilax are weighed by parts; (2) All the weighed raw medicinal materials are mixed and placed in an extraction tank, 8-12 times the weight of water of the total raw medicinal materials is added, after soaking, the first decoction is carried out, after heating to boiling, the state of slight boiling is maintained for a period of time, filtration is carried out, and the filtrate is collected; (3) 6-10 times the weight of water of the total raw medicinal materials is added to the dregs of step (2), the second decoction is carried out, after heating to boiling, the state of slight boiling is maintained for a period of time, filtration is carried out, and the filtrate is collected; (4) The two filtrates are combined, after standing and precipitation, the supernatant is taken, concentration is carried out, the supernatant is concentrated under reduced pressure at 60-70°C, and the extract is obtained, which has a relative density of 1.10-1.25 at 60°C; (5) The extract is dried, and is pulverized, and the traditional Chinese medicine composition is obtained.

6. The method of claim 5, wherein the method is for preparing the traditional Chinese medicine composition for treating acute kidney injury. The soaking time in step (2) is 20-40 minutes, and the state of slight boiling is maintained for 1-2 hours.

7. The method of claim 5, wherein the method is characterized by the following steps: (a) mixing the ingredients of the Chinese medicine composition; (b) drying the mixture; (c) grinding the dried mixture; (d) mixing the ground mixture with the other ingredients; and (e) packaging the mixture. In step (3), the state of slight boiling is maintained for 1-1.5 hours. 8.The preparation method of the traditional Chinese medicine composition for treating acute kidney injury according to claim 5, characterized in that: In step (5), the drying treatment is spray drying or vacuum reduced pressure drying.