Skin care composition with multiple effects as well as preparation method and application thereof

Abstract

The invention provides a skin care composition with multiple effects as well as a preparation method and application thereof, and the skin care composition comprises the following raw materials in percentage by weight: 0.001-10% of a polygonum cuspidatum extract, 0.001-10% of a trillium tschonoskii extract and 80-99.998% of a carrier matrix, the weight ratio of the polygonum cuspidatum extract to the trillium tschonoskii extract is (1: 5)-(5: 1). Through the synergistic anti-oxidation effect of the polygonum cuspidatum extract and the trillium tschonoskii extract, the scavenging rate of DPPH free radicals can reach 85% or above; the multiple skin care effects of resisting aging, whitening and removing freckles, relieving and repairing and the like are achieved; the raw materials adopt natural plant sources, are low in irritation and are suitable for various skin types including sensitive skin; by optimizing the extraction process and the formula combination, the problem that the plant extract is easy to discolor and degrade in cosmetics is solved, and the shelf life of the product is prolonged. The product can be widely applied to various cosmetic formulations such as skin cream, emulsion, essence, facial mask, facial cleanser and the like.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of cosmetics, and particularly relates to a skin care composition with multiple effects and a preparation method and application thereof. BACKGROUND

[0002] Giant knotweed is a traditional Chinese medicinal material. The extract of giant knotweed is rich in active ingredients such as resveratrol and emodin, and has significant antioxidant properties. Studies have shown that the alcohol extract of giant knotweed can increase the activity of intracellular superoxide dismutase (SOD) by about 20%, effectively scavenge free radicals, and thus play an antioxidant role. In addition, compositions containing giant knotweed root extract have also been proven to have the effect of enhancing skin elasticity and improving wrinkles, such as the combination of giant knotweed root extract with 2,3-butanediol or deamidated collagen disclosed in CN115590795A patent, which can promote the synthesis of type I collagen hydroxy-terminal extension peptide (PICP).

[0003] However, the existing technology uses giant knotweed extract alone or simply compounds it with other ingredients, which has limitations such as single effect and insufficient stability. For example, the giant knotweed extract in some formulations may be irritating to the skin at high concentrations, while at low concentrations, the effect is not significant.

[0004] Trillium tschonoskii Maxim extract, as a natural plant ingredient, has begun to be applied in the field of cosmetics in recent years. The existing technology such as CN108354859A patent discloses that Trillium tschonoskii Maxim extract can be used in acne-removing daily-use products, which has the functions of inhibiting bacteria, removing acne, improving and conditioning skin, and protecting the natural barrier of the skin. In addition, CN107115448A patent also reports that Trillium tschonoskii Maxim, as a component of whitening and anti-aging traditional Chinese medicine composition, is used in combination with Rhodiola rosea and Camellia japonica, etc., to achieve the dual effects of whitening and anti-aging.

[0005] However, the existing technology mainly applies Trillium tschonoskii Maxim extract to specific effect products (such as acne-removing products), and the application range is narrow, and the synergistic effect of Trillium tschonoskii Maxim extract with other ingredients has not been fully researched and utilized. SUMMARY

[0006] The present application is conducted in view of the above-mentioned problems, and aims to provide a synergistic application of giant knotweed and Trillium tschonoskii Maxim extract in cosmetics and a cosmetic formulation containing the same. The synergistic effect of giant knotweed and Trillium tschonoskii Maxim extract is fully utilized to achieve multiple effects such as antioxidant, anti-aging, whitening, and soothing. A stable and safe cosmetic formulation is provided, which is suitable for various skin types. The application range of giant knotweed and Trillium tschonoskii Maxim extract in cosmetics is expanded, and the skin care effect and value thereof are improved.

[0007] The first aspect of the present application provides a skin care composition with multiple efficacy, comprising the following raw materials in percentage by weight, rhizoma polygoni multiflori extract 0.001-10%, trillium tschonoskii maxim extract 0.001-10% and carrier matrix 80-99.998%; the weight ratio of the rhizoma polygoni multiflori extract to the trillium tschonoskii maxim extract is 1:5-5:1.

[0008] In any embodiment, the rhizoma polygoni multiflori extract is 0.1-5%, the trillium tschonoskii maxim extract is 0.1-5% and the carrier matrix is 90-99.8%; the weight ratio of the rhizoma polygoni multiflori extract to the trillium tschonoskii maxim extract is 1:1-2:1.

[0009] In any embodiment, the carrier matrix comprises a water-based system, an emulsion system and a gel system, the water-based system is water, a high-concentration moisturizing agent and a thickening agent; the emulsion system is an aqueous phase, an oil phase, an emulsifier and a thickening agent; the gel system is water, a gel-forming agent and a neutralizing agent. Each component is selected and added as needed.

[0010] The high-concentration moisturizing agent is composed of 5-15% of polyol moisturizing agent and 0.1-0.5% of hyaluronic acid or its derivative by weight percentage of the composition. A normal addition amount of 2-5% has a good moisturizing effect, and the addition amount in the present application belongs to a high-concentration moisturizing agent. The high-concentration moisturizing agent serves as a solvent and stabilizer for the two extracts on the one hand, and promotes the transdermal absorption of active ingredients to make their antioxidant and anti-aging efficacy remarkable.

[0011] The thickening agent includes one or more of carbomer 940 / 980, xanthan gum, hydroxyethyl cellulose, acryloyldimethyltaurine ammonium / VP copolymer (Aristoflex AVC).

[0012] The aqueous phase contains deionized water, glycerol and butylene glycol; the oil phase is selected from one or more of caprylic / capric triglyceride, jojoba oil and shea butter.

[0013] The emulsifier is one or more of polyglyceryl-3 diisostearate, sorbitan olivate, sodium stearoyl glutamate and PEG-100 stearate.

[0014] The gel-forming agent is one or more of carbomer 940 / 980, acrylate / C10-30 alkanol acrylate crosspolymer (Ultrez 20 / 21), xanthan gum, gellan gum and sodium polyacrylate (NP-700).

[0015] The neutralizing agent is one or more of triethanolamine (TEA), sodium hydroxide, potassium hydroxide, arginine, aminomethyl propanol (AMP) and tetrahydroxypropyl ethylenediamine (Neutrol TE).

[0016] In any embodiment, the humectant is at least one of butylene glycol, glycerin, hyaluronic acid, and is present in the composition in an amount of 1-30%.

[0017] In any embodiment, the skin conditioning agent is at least one of niacinamide, amino acid, vitamin, zinc gluconate, and is present in the composition in an amount of 0.1-10%.

[0018] The extract can also add Scutellaria baicalensis Georgi extract, Rhodiola rosea extract, licorice extract, etc. to further enhance the specific efficacy.

[0019] The second aspect of the present application also provides a method for preparing a skin care composition with multiple effects, comprising the following steps: 1) Preparation of Polygonum cuspidatum extract: dry Polygonum cuspidatum rhizome is crushed, extracted with ethanol-water solution, filtered, concentrated, and dried to obtain Polygonum cuspidatum extract; 2) Preparation of Trillium tschonoskii extract: Trillium tschonoskii whole grass is crushed, extracted with 8-10 times the amount of water, filtered, concentrated, and dried to obtain Trillium tschonoskii extract; 3) Composition preparation: Polygonum cuspidatum extract and Trillium tschonoskii extract are dissolved in a solvent according to the proportion; and mixed with a carrier matrix, stirred uniformly at a temperature of 60-80°C; cooled to room temperature, add heat-sensitive ingredients (such as vitamins, essences, etc.); homogenized to obtain the final composition.

[0020] In any embodiment, the solvent is butylene glycol, pentylene glycol, or hexylene glycol.

[0021] In any embodiment, the preparation of Polygonum cuspidatum extract: dry Polygonum cuspidatum rhizome is crushed, extracted with 60-80% ethanol at 60-80°C for 2-3 times, each time for 1-2 hours, the extract is combined, filtered, concentrated, and dried to obtain Polygonum cuspidatum extract; the preparation of Trillium tschonoskii extract: Trillium tschonoskii whole grass is crushed, 8-10 times the amount of water is added, and extracted at 85±3°C for 2-3 times, each time for 1±0.2 hours, the extract is combined, filtered, concentrated, and dried to obtain Trillium tschonoskii extract.

[0022] In any embodiment, the preparation of Polygonum cuspidatum extract: dry Polygonum cuspidatum rhizome is crushed, extracted with 70% ethanol at 50-60°C for 0.5-1 hours with the assistance of ultrasonic power 300-500W or microwave frequency 2450MHz, filtered, concentrated, and dried to obtain Polygonum cuspidatum extract; the preparation of Trillium tschonoskii extract: Trillium tschonoskii whole grass is crushed, 8-10 times the amount of water is added, and 0.5%-1% cellulase is added for pretreatment, and then extracted at 80-90°C for 2-3 times, each time for 1-2 hours, the extract is combined, filtered, concentrated, and dried to obtain Trillium tschonoskii extract.

[0023] In any embodiment, in the preparation of the extract of Polygonum cuspidatum, after concentration, D101 macroporous resin is used, and 70% ethanol is used as the eluent; in the preparation of the extract of Trillium tschonoskii, after concentration, AB-8 macroporous resin is used, and 30%-40% ethanol is used for elution.

[0024] The third aspect of the present application provides a skin care composition with multiple effects, a preparation method thereof and application, and the application of the composition of the first aspect of the present application or the composition prepared according to the method of the second aspect of the present application in cosmetics.

[0025] In any embodiment, the cosmetic is a serum, and 0.1%-0.3% of xanthan gum or hyaluronic acid is added to the composition.

[0026] In any embodiment, the cosmetic is a cream, and polyglyceryl-3 diisostearate is selected as the emulsifier in the composition, and the pH value of the formula is controlled to be 5.5-6.5.

[0027] In any embodiment, the cosmetic is a mask, and 0.2%-0.5% of propylene glycol cosolvent is added to the composition.

[0028] Compared with the prior art, the present application has the following remarkable beneficial effects: 1. Synergistic antioxidant effect: the extract of Polygonum cuspidatum and the extract of Trillium tschonoskii exhibit a significant synergistic antioxidant effect at a specific ratio. Experiments show that when the two are compounded at a ratio of 1:1, the clearance rate of DPPH free radicals can reach more than 85%, which is much higher than that of a single extract (the clearance rate of the extract of Polygonum cuspidatum alone is about 60%, and the clearance rate of the extract of Trillium tschonoskii alone is about 50%).

[0029] 2. Multiple skin care effects: Anti-aging: the extract of Polygonum cuspidatum promotes the synthesis of I-type procollagen hydroxy-terminal extension peptide (PICP), thereby enhancing the elasticity of the skin; the extract of Trillium tschonoskii indirectly enhances the anti-aging effect by repairing the skin barrier.

[0030] Whitening and freckle removal: the extract of Trillium tschonoskii has the effect of inhibiting the activity of tyrosinase, and the resveratrol in the extract of Polygonum cuspidatum can reduce the synthesis of melanin, and the two achieve a whitening effect in combination.

[0031] Relief and repair: the extract of Trillium tschonoskii has good skin soothing and skin barrier repair functions, and in combination with the anti-inflammatory effect of the extract of Polygonum cuspidatum, it is suitable for sensitive skin.

[0032] 4. High safety: the ingredients are of natural plant origin, have low irritation, and are suitable for various skin types, including sensitive skin.

[0033] Good stability: By optimizing the extraction process and formula combination, the problem of easy discoloration and degradation of plant extracts in cosmetics is solved, and the shelf life of the product is prolonged.

[0034] 5. Wide application: the composition can be used in various cosmetic dosage forms such as skin care cream, emulsion, essence, mask, cleansing milk, etc. BRIEF DESCRIPTION OF DRAWINGS

[0035] Figure 1 Radical scavenging rate column chart of products obtained by the preparation method of the present application at different ratios of polygonum cuspidatum extract: trillium tschonoskii extract; Figure 2 Tyrosinase inhibition rate column chart of products obtained by the preparation method of the present application at different ratios of polygonum cuspidatum extract: trillium tschonoskii extract and arbutin. DETAILED DESCRIPTION

[0036] Hereinafter, specific embodiments of the skin care composition with multiple effects of the present application and the preparation method and application thereof are specifically disclosed with appropriate reference to the accompanying drawings. However, there will be cases where unnecessary detailed description is omitted. For example, there are cases where detailed description of matters well known in the art, repeated description of substantially the same structure are omitted. This is to avoid the following description from becoming unnecessarily lengthy and to facilitate understanding of those skilled in the art. In addition, the accompanying drawings and the following description are provided to enable those skilled in the art to fully understand the present application, and are not intended to limit the subject matter recited in the claims.

[0037] The "range" disclosed in the present application is defined in the form of lower limit and upper limit, and the given range is defined by selecting a lower limit and an upper limit, and the selected lower limit and upper limit define the boundaries of the specific range. The range defined in this way can include or not include the end value, and can be arbitrarily combined, i.e. any lower limit can be combined with any upper limit to form a range. For example, if the ranges of 60-120 and 80-110 are listed for a particular parameter, it is understood that the ranges of 60-110 and 80-120 are also contemplated. In addition, if the minimum range values of 1 and 2 are listed, and if the maximum range values of 3, 4 and 5 are listed, the following ranges can all be contemplated: 1-3, 1-4, 1-5, 2-3, 2-4 and 2-5. In the present application, unless otherwise stated, the numerical range "a-b" represents a shorthand notation for any real combination of integers between a and b, where a and b are both real numbers. For example, the numerical range "0-5" means that all real numbers between "0-5" have been listed herein, and "0-5" is just a shorthand notation for these numerical combinations. In addition, when a parameter is expressed as ≥2 integers, it is equivalent to disclose that the parameter is, for example, integer 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, etc.

[0038] If not particularly specified, all the embodiments and optional embodiments of the present application can be combined with each other to form new technical solutions.

[0039] If not particularly specified, all the technical features and optional technical features of the present application can be combined with each other to form new technical solutions.

[0040] If not particularly specified, all the steps of the present application can be performed in sequence or randomly, and preferably in sequence. For example, the method comprises steps (a) and (b), which means that the method can comprise steps (a) and (b) performed in sequence, or steps (b) and (a) performed in sequence. For example, the method also comprises step (c), which means that step (c) can be added to the method in any order, for example, the method can comprise steps (a), (b) and (c), or steps (a), (c) and (b), or steps (c), (a) and (b), etc.

[0041] If not particularly specified, the "includes" and "contains" mentioned in the present application are open-ended, and can also be closed. For example, the "includes" and "contains" can mean that other components not listed can also be included or contained, or only the listed components can be included or contained.

[0042] If not particularly specified, in the present application, the term "or" is inclusive. For example, the phrase "A or B" means "A, B, or both A and B". More specifically, any one of the following conditions satisfies the condition "A or B": A is true (or exists) and B is false (or does not exist); A is false (or does not exist) and B is true (or exists); or both A and B are true (or exist).

[0043] In one embodiment of the present application, the present application proposes a skin care composition with multiple effects, comprising the following raw materials in percentage by weight: rhizoma polygoni multifidi extract 0.001-10%, trillium tschonoskii maxim extract 0.001-10%, and carrier matrix 80-99.998%; the weight ratio of the rhizoma polygoni multifidi extract to the trillium tschonoskii maxim extract is 1:5-5:1.

[0044] For the first time, rhizoma polygoni multifidi and trillium tschonoskii maxim are combined to cover four major effects of antioxidant, anti-aging, whitening and spot removal, and soothing and repair through synergistic effect, meeting the needs of consumers for "multi-functional skin care products" and breaking through the limitations of single or simple compounding effects.

[0045] It is not a "simple splicing" of the two extracts, but through screening of a specific ratio (1:5 to 5:1, preferably 1:1 to 2:1), the synergistic effect of the two in the fields of antioxidant and whitening is activated, breaking the conventional cognition that "plant extract compounding is only for effect superposition".

[0046] In some embodiments, the extract of Giant Knotweed 0.1-5%, the extract of Trillium 0.1-5%, and the carrier matrix 90-99.8%; the weight ratio of the extract of Giant Knotweed to the extract of Trillium is 1:1-2:1.

[0047] In some embodiments, the carrier matrix comprises a water-based system, an emulsion system, and a gel system, the water-based system being water, a high-concentration moisturizer, and a thickening agent; the emulsion system being an aqueous phase, an oil phase, an emulsifier, and a thickening agent; the gel system being water, a gel-forming agent, and a neutralizing agent.

[0048] In the present application, the carrier matrix is a basic system for dissolving, dispersing, and carrying active ingredients (such as extracts of Giant Knotweed and Trillium), which constitutes the main body of the product and directly determines the dosage form, stability, skin feel, and ultimate efficacy of the product.

[0049] The essence liquid has a water-based / gel system as the matrix framework: water + high-concentration moisturizer (butylene glycol / glycerol) + thickening agent (xanthan gum); the extract is first dissolved in a cosolvent such as butylene glycol, and then mixed with the aqueous phase to ensure uniform dissolution.

[0050] The emulsion / cream has an emulsion system as the matrix framework: aqueous phase + oil phase + emulsifier + thickening agent; the extract is usually added to the aqueous phase or the oil phase (depending on the solubility) and added during the cooling stage (<50°C) after emulsification.

[0051] The gel / jelly has a gel system as the matrix framework: water + gel-forming agent (carbomer) + neutralizing agent (triethanolamine); the carbomer system is sensitive to ions, and it is necessary to ensure that the extract is compatible with the system and does not flocculate.

[0052] In some embodiments, the moisturizer is at least one of butylene glycol, glycerol, and hyaluronic acid, and the content in the composition is 1-30%.

[0053] The extracts of Giant Knotweed and Trillium are easily soluble in water / butylene glycol, but may precipitate slightly during long-term storage. The addition of 1-3% of hyaluronic acid (a high-molecular polymer) improves the dispersion stability of the extract through thickening and enhances the skin feel.

[0054] In some embodiments, the skin conditioner is at least one of niacinamide, amino acid, vitamin, and zinc gluconate, and the content in the composition is 0.1-10%.

[0055] The addition of 0.5-1% of zinc gluconate in the formula cooperates with the two extracts to regulate the secretion of sebaceous glands and supplements the "sebum secretion amount in vitro detection experiment" to expand the applicable skin type range of the product.

[0056] In some embodiments, the emulsifier, preservative, essence.

[0057] Other plant extracts: such as Scutellaria baicalensis Georgi extract, Rhodiola rosea extract, licorice extract, etc., to further enhance specific efficacy.

[0058] In one embodiment of the present application, the present application provides a method for preparing a skin care composition with multiple effects, comprising the following steps: 1) Preparation of Polygonum cuspidatum extract: dry Polygonum cuspidatum rhizome is crushed, extracted with ethanol-water solution, filtered, concentrated, and dried to obtain Polygonum cuspidatum extract; 2) Preparation of Trillium tschonoskii extract: Trillium tschonoskii whole plant is crushed, extracted with 8-10 times the amount of water, filtered, concentrated, and dried to obtain Trillium tschonoskii extract; 3) Composition preparation: Polygonum cuspidatum extract and Trillium tschonoskii extract are dissolved in solvent according to the proportion; and mixed with carrier matrix, stirred uniformly at a temperature of 60-80°C; cooled to room temperature, add heat-sensitive ingredients (such as vitamins, essence, etc.); homogenized to obtain the final composition.

[0059] In some embodiments, the solvent is butanediol, pentanediol, or hexanediol.

[0060] In some embodiments, the preparation of Polygonum cuspidatum extract: dry Polygonum cuspidatum rhizome is crushed, extracted with 60-80% ethanol at 60-80°C for 2-3 times, each for 1-2 hours, the extract is combined, filtered, concentrated, and dried to obtain Polygonum cuspidatum extract; the preparation of Trillium tschonoskii extract: Trillium tschonoskii whole plant is crushed, 8-10 times the amount of water is added, and extracted at 85±3°C for 2-3 times, each for 1±0.2 hours, the extract is combined, filtered, concentrated, and dried to obtain Trillium tschonoskii extract.

[0061] In some embodiments, the preparation of Polygonum cuspidatum extract: dry Polygonum cuspidatum rhizome is crushed, extracted with 70% ethanol at 50-60°C for 0.5-1 hours with the assistance of ultrasonic power 300-500W or microwave frequency 2450MHz, filtered, concentrated, and dried to obtain Polygonum cuspidatum extract; the preparation of Trillium tschonoskii extract: Trillium tschonoskii whole plant is crushed, 8-10 times the amount of water is added, and 0.5%-1% cellulase is added for pretreatment, and then extracted at 80-90°C for 2-3 times, each for 1-2 hours, the extract is combined, filtered, concentrated, and dried to obtain Trillium tschonoskii extract.

[0062] The experimental verification shows that the method can increase the extraction rate of resveratrol by 15%-20%, shorten the extraction time to 0.5-1 hour (the original process is 1.5 hours), reduce the energy consumption, and reduce the damage to heat-sensitive components; the water extraction of Trillium tschonoskii combined with enzyme pretreatment can destroy the plant cell wall structure, increase the dissolution rate of water-soluble polysaccharides and saponins related to antibacterial and repair by 10%-15%, and further enhance the soothing and repair effect.

[0063] In some embodiments, in the preparation of the rhizoma Polygoni Cuspidati extract, after concentration, D101 macroporous resin is used, and 70% ethanol is used as an eluent; in the preparation of the Trillium tschonoskii extract, after concentration, AB-8 macroporous resin is used, and 30%-40% ethanol is used for elution.

[0064] Simple concentration extraction may leave a small amount of plant protein, tannin and other impurities, and long-term use may increase the risk of stimulating sensitive skin. By adding a macroporous resin purification step after the concentration step, more than 80% of the tannin impurities in the rhizoma Polygoni Cuspidati extract can be removed; the Trillium tschonoskii extract can enrich water-soluble active ingredients, reduce the content of invalid impurities, improve the purity of the extract, and reduce the compatibility conflict with other ingredients (such as emulsifiers and preservatives) in the subsequent formula.

[0065] In one embodiment of the present application, the present application provides a skin care composition with multiple effects, a preparation method and application thereof, and the application of the composition of the first aspect of the present application or the composition prepared according to the method of the second aspect of the present application in cosmetics.

[0066] In some embodiments, the cosmetic is a serum, and 0.1%-0.3% of xanthan gum or hyaluronic acid is added to the composition.

[0067] In some embodiments, the cosmetic is a cream, and polyglyceryl-3 diisostearate is selected as the emulsifier in the composition, and the pH value of the formula is controlled to be 5.5-6.5.

[0068] In some embodiments, the cosmetic is a mask, and 0.2%-0.5% of propylene glycol cosolvent is added to the composition.

[0069] Examples Hereinafter, the examples of the present application will be described. The examples described below are exemplary and are only used to explain the present application, and cannot be understood as a limitation of the present application. If the specific technology or condition is not specified in the examples, the technology or condition described in the literature in the art or according to the product instruction is used. If the reagent or instrument is not specified by the manufacturer, it is a conventional product that can be obtained by market purchase.

[0070] Example 1 A skin care composition with multiple efficacy and its preparation method, comprising the following steps: 1) Preparation of Polygonum Cuspidatum Extract Take 1 kg of dried Polygonum Cuspidatum rhizome, crush into coarse powder, add 6 L of 70% ethanol solution, reflux extract 2 times at 75°C, each for 1.5 hours. Combine the extract, filter, concentrate under reduced pressure to a relative density of 1.10-1.15 (60°C), spray dry to obtain about 120 g of Polygonum Cuspidatum extract.

[0071] 2) Preparation of Trillium tschonoskii Maxim. Extract Take 1 kg of dried Trillium tschonoskii Maxim. whole herb, crush, add 8 L of deionized water, extract 3 times at 85°C, each for 1 hour. Combine the extract, filter, concentrate under reduced pressure to a relative density of 1.05-1.10 (60°C), freeze dry to obtain about 150 g of Trillium tschonoskii Maxim. extract.

[0072] 3) Composition preparation: Dissolve Polygonum Cuspidatum extract and Trillium tschonoskii Maxim. extract in butanediol 20% according to the proportion of 5%; mix with carrier matrix, stir at a temperature of 60-80°C for 30 min to make it uniform; cool to room temperature, add heat-sensitive ingredients (such as vitamins, essences, etc.); homogenize at 5000 rpm for 5 min to obtain the final composition.

[0073] Example 2 A skin care composition with multiple efficacy and its preparation method, comprising the following steps: 1) Preparation of Polygonum Cuspidatum Extract Take 1 kg of dried Polygonum Cuspidatum rhizome, crush into coarse powder, add 6 L of 70% ethanol solution, reflux extract 2 times at 75°C, each for 1.5 hours. Combine the extract, filter, concentrate under reduced pressure to a relative density of 1.10-1.15 (60°C), spray dry to obtain about 120 g of Polygonum Cuspidatum extract.

[0074] 2) Preparation of Trillium tschonoskii Maxim. Extract Take 1 kg of dried Trillium tschonoskii Maxim. whole herb, add 8-10 times the amount of water, add 0.5%-1% cellulase of total weight for pretreatment, then extract 2-3 times at 80-90°C, each for 1-2 hours, the dissolution rate of water-soluble polysaccharides and saponins is increased by 10%-15%; combine the extract, filter, concentrate, dry to obtain Trillium tschonoskii Maxim. extract, freeze dry to obtain about 170.8 g of Trillium tschonoskii Maxim. extract.

[0075] 3) Composition preparation: Polygonum cuspidatum extract and Trillium tschonoskii extract are dissolved in pentylene glycol 15% at a ratio of 3%; mixed with the carrier matrix, stirred at a temperature of 60-80°C for 20 min to homogeneity; cooled to room temperature, added with heat-sensitive ingredients (such as vitamins, essences, etc.); homogenized at 4000 rpm for 3 min, to obtain the final composition.

[0076] Example 3 A skin care composition with multiple effects and a preparation method thereof, comprising the following steps: 1) Preparation of Polygonum cuspidatum extract Take 1 kg of dried Polygonum cuspidatum rhizome, crush the dried Polygonum cuspidatum rhizome, and extract it with 70% ethanol at 50-60°C for 0.5-1 hour with the assistance of ultrasonic power 300-500W or microwave frequency 2450MHz. Filter, concentrate, and then use D101 macroporous resin with 70% ethanol as the eluent to remove more than 80% of the tannin impurities. Dry to obtain Polygonum cuspidatum extract, and spray dry to obtain about 132g of Polygonum cuspidatum extract.

[0077] 2) Preparation of Trillium tschonoskii extract Take 1 kg of dried Trillium tschonoskii whole plant, add 8-10 times the amount of water, and add 0.5%-1% cellulase by total weight for pretreatment. Then extract it at 80-90°C for 2-3 times, each time for 1-2 hours. Combine the extract, filter, and concentrate. Then use AB-8 macroporous resin with 30%-40% ethanol to elute, which can enrich water-soluble active ingredients, reduce the content of invalid impurities, and improve the purity of the extract while reducing the compatibility conflict with other ingredients (such as emulsifiers, preservatives) in the subsequent formulation. Dry to obtain Trillium tschonoskii extract, and freeze-dry to obtain about 165g of Trillium tschonoskii extract.

[0078] 3) Preparation of the composition: Polygonum cuspidatum extract and Trillium tschonoskii extract are dissolved in 1,2-hexanediol 5% at a ratio of 1%; mixed with the carrier matrix, stirred at a temperature of 60-80°C for 10 min to homogeneity; cooled to room temperature, added with heat-sensitive ingredients (such as vitamins, essences, etc.); homogenized at 3000 rpm for 2 min, to obtain the final composition.

[0079] Test Example 1 Verification experiment of the synergistic effect of Polygonum cuspidatum and Trillium tschonoskii extract To verify the synergistic effect of Polygonum cuspidatum and Trillium tschonoskii extract, DPPH free radical scavenging experiment and tyrosinase inhibition experiment were conducted. The preparation method of the composition is obtained by Example 1.

[0080] 1) DPPH free radical scavenging experiment Prepare different proportions of extract solutions of polygonum cuspidatum and trillium tschonoskii (total concentration of 0.1 mg / mL), and determine the free radical scavenging rate by the conventional DPPH method. The results are shown in Table 1: Table 1: DPPH free radical scavenging rate experimental results of different proportions of polygonum cuspidatum and trillium tschonoskii extracts:

[0081] The experimental results show that when the proportion of polygonum cuspidatum extract and trillium tschonoskii extract is 1:1 to 2:1, the DPPH free radical scavenging rate is significantly higher than the theoretical additive value, showing obvious synergistic antioxidant effect.

[0082] 2) Tyrosinase inhibition experiment Prepare different proportions of extract solutions as above, and determine the inhibition rate on tyrosinase. The results show that when the proportion is 1:1, the tyrosinase inhibition rate reaches 75.3%, which is significantly higher than that of single extract (polygonum cuspidatum alone is 45.2%, trillium tschonoskii alone is 38.7%), indicating that there is also a synergistic effect in whitening.

[0083] The present application is not a simple test of "any ratio", but through a large number of experiments to screen out the optimal ratio range (1:1 to 2:1) of synergistic effect. As shown in the DPPH free radical scavenging experiment, the scavenging rate reaches 86.7% at a ratio of 1:1, which is much higher than that of single extract (polygonum cuspidatum 60.2%, trillium tschonoskii 49.8%), and significantly exceeds the "theoretical additive value" of the two; in the tyrosinase inhibition experiment, the inhibition rate is 75.3% at a ratio of 1:1, which is also much higher than that of single extract (polygonum cuspidatum 45.2%, trillium tschonoskii 38.7%).

[0084] The optimization of the extraction process also has creativity: polygonum cuspidatum uses "60-80% ethanol, 60-80°C reflux extraction", which not only ensures the dissolution of liposoluble active ingredients such as resveratrol and emodin, but also avoids the destruction of components by high temperature; trillium tschonoskii uses "8-10 times water, 80-90°C extraction", which adapts to the dissolution requirements of its water-soluble active ingredients (such as bacteriostatic and repair-related components). This combination of "targeted extraction process + precise ratio" is not easily obtained by conventional experiments for those skilled in the art.

[0085] In terms of antioxidant effect: the scavenging rate of 1:1 to 2:1 ratio (80.3%-86.7%) is increased by 33%-74% compared with single extract, and the synergistic effect cannot be achieved by simple compounding of existing technology; In terms of whitening: the tyrosinase inhibition rate of 1:1 ratio (75.3%) is increased by 66%-95% compared with single extract, solving the problem of "weak whitening effect of single component and reliance on chemical whitening agents"; The synergistic combination of anti-aging and soothing: rhizoma polygoni multiflori promotes collagen synthesis (enhances elasticity) and radix ginseng repairs the barrier (reduces external damage) to form a double mechanism of "active anti-aging + passive protection", which is suitable for sensitive skin anti-aging, which cannot be achieved by existing single extract or simple combination.

[0086] The present application breaks through the conventional technology in the aspects of "extract combination selection", "ratio and process optimization", solves the industry pain points of single efficacy, insufficient synergy and poor stability, and produces unexpected technical effects such as "synergistic antioxidant", "multiple efficacy integration" and "high safety".

[0087] It should be noted that the present application is not limited to the above embodiments. The above embodiments are only examples, and embodiments having the same technical idea and playing the same role and effect within the scope of the technical solutions of the present application are included in the technical scope of the present application. In addition, within the scope of the main idea of the present application, various modifications that can be thought of by those skilled in the art are applied to the embodiments, and other ways constructed by combining part of the constituent elements in the embodiments are also included in the scope of the present application.

Claims

1. A skin care composition having multiple efficacy, characterized in that, The composition comprises the following raw materials by weight percentage: 0.001-10% of Polygonum cuspidatum extract, 0.001-10% of Trillium tschonoskii Maxim extract, and 80-99.998% of carrier matrix; the weight ratio of the Polygonum cuspidatum extract to the Trillium tschonoskii Maxim extract is 1:5-5:

1.

2. The composition of claim 1, wherein, The carrier matrix comprises a water-based system, an emulsified system, and a gel system; the water-based system comprises water, a high-concentration moisturizer, and a thickening agent; the emulsified system comprises an aqueous phase, an oil phase, an emulsifier, and a thickening agent; the gel system comprises water, a gel-forming agent, and a neutralizing agent; the moisturizer is at least one of butanediol, glycerol, and hyaluronic acid, and the content in the composition is 1-30%; the skin conditioner is at least one of nicotinamide, an amino acid, a vitamin, and zinc gluconate, and the content in the composition is 0.1-10%; the emulsifier, a preservative, and a fragrance.

3. The composition according to claim 1 or 2, characterized in that, The carrier matrix further comprises a heat-sensitive component, and the heat-sensitive component comprises a vitamin and a fragrance.

4. A preparation method of a skin care composition with multiple effects, comprising the following steps: 1) Preparation of Polygonum cuspidatum extract: dry Polygonum cuspidatum rhizome is crushed, extracted with an ethanol-water solution, filtered, concentrated, and dried to obtain Polygonum cuspidatum extract; 2) Preparation of Trillium tschonoskii Maxim extract: Trillium tschonoskii Maxim whole herb is crushed, extracted with 8-10 times the amount of water, filtered, concentrated, and dried to obtain Trillium tschonoskii Maxim extract; 3) Preparation of the composition: Polygonum cuspidatum extract and Trillium tschonoskii Maxim extract are dissolved in a solvent according to a proportion, and then mixed with a carrier matrix, stirred uniformly at a temperature of 60-80°C, cooled to room temperature, and then added with a heat-sensitive component, and finally homogenized to obtain a final composition.

5. The preparation method according to claim 4, characterized in that, The solvent is butanediol, pentanediol, or hexanediol.

6. The preparation method according to claim 4, characterized in that, The Polygonum cuspidatum extract is prepared by crushing dry Polygonum cuspidatum rhizome, refluxing extraction with 60-80% ethanol at 60-80°C for 2-3 times, each time for 1-2 hours, combining the extraction solutions, filtering, concentrating, and drying to obtain the Polygonum cuspidatum extract; and the Trillium tschonoskii Maxim extract is prepared by crushing Trillium tschonoskii Maxim whole herb, adding 8-10 times the amount of water, extracting at 85±3°C for 2-3 times, each time for 1±0.2 hours, combining the extraction solutions, filtering, concentrating, and drying to obtain the Trillium tschonoskii Maxim extract.

7. The preparation method according to claim 4, characterized in that, The Polygonum cuspidatum extract is prepared by crushing dry Polygonum cuspidatum rhizome, extracting with 70% ethanol at 50-60°C for 0.5-1 hour by ultrasonic power of 300-500W or microwave frequency of 2450MHz, filtering, concentrating, and drying to obtain the Polygonum cuspidatum extract; and the Trillium tschonoskii Maxim extract is prepared by crushing Trillium tschonoskii Maxim whole herb, adding 8-10 times the amount of water, adding 0.5%-1% cellulase based on the total weight for pretreatment, extracting at 80-90°C for 2-3 times, each time for 1-2 hours, combining the extraction solutions, filtering, concentrating, and drying to obtain the Trillium tschonoskii Maxim extract.

8. The production method according to claim 4, 6 or 7, characterized by, In the preparation of the Polygonum cuspidatum extract, D101 macroporous resin is used for elution after concentration, and 70% ethanol is used as an eluent; and in the preparation of the Trillium tschonoskii Maxim extract, AB-8 macroporous resin is used for elution after concentration, and 30%-40% ethanol is used as an eluent.

9. Use of a skin care composition having multiple efficacy, comprising the use of the composition of any one of claims 1-3 or the composition prepared according to the method of any one of claims 4-8 in a cosmetic product.

10. Use according to claim 9, characterized in that, The cosmetic product is a serum, a cream or a mask; the composition of the serum adds 0.1%-0.3% of xanthan gum or hyaluronic acid; the emulsifier in the composition of the cream is selected from polyglyceryl-3 diisostearate, and the pH value of the formula is controlled at 5.5-6.5; the composition of the mask adds 0.2%-0.5% of propylene glycol cosolvent.

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