Preparation method and application of a compound solution for wet wipes with long-lasting cooling and secondary cooling effects.

Abstract

This invention belongs to the field of nursing product technology, specifically disclosing a preparation method and application of a wet wipe compound solution with long-lasting cooling and secondary cooling sensations; the wet wipe compound solution is prepared from the following raw materials by weight: 80-96 parts solvent, 0.1-2 parts cooling agent composition, 1-10 parts humectant, 0.1-2 parts solubilizer, and 0.1-5 parts preservative; the preparation of the wet wipe compound solution includes the following steps: (1) mixing water, preservative, and humectant, and then heating and stirring to obtain phase a; (2) mixing solubilizer and cooling agent composition, and then heating and stirring to obtain phase b; (3) adding phase b to phase a, and then heating and stirring to obtain the wet wipe compound solution. The wet wipe compound solution provided by this invention, through a unique cooling agent composition and a specific preparation process, can provide multiple cooling sensations, including immediate cooling, long-lasting cooling, and secondary cooling sensations triggered by sweat or moisture during use, and is suitable for the preparation of wet wipes.

Description

Technical Field

[0001] This invention belongs to the field of nursing product technology, specifically relating to a preparation method and application of a compound solution for wet wipes with long-lasting cooling and secondary cooling effects. Background Technology

[0002] As a convenient personal hygiene product, wet wipes are widely used in daily life, medical disinfection, maternal and infant care, and cosmetics. To enhance the user experience, many cooling wet wipes with added cooling agents have appeared on the market. These wipes typically provide a cooling sensation upon application by adding cooling agents such as menthol, WS-3, and WS-23 to the wiping compound.

[0003] However, the existing cooling wipes compound solution has the following obvious drawbacks:

[0004] The cooling sensation is singular and short-lived: Most cooling agents are volatile, small-molecule substances. Once opened, the cooling agent will gradually evaporate and become ineffective even if not used. The cooling sensation reaches its peak quickly and then rapidly diminishes after wiping the skin, resulting in a very short duration that cannot meet users' needs for sustained coolness.

[0005] Irritation issues: Menthol-based cooling agents need to bind to the skin's cold receptors (TRPM8) to produce a cooling sensation, but excessively high concentrations can overactivate these receptors, even activating pain receptors (TRPA1, etc.), leading to burning, tingling, itching, or numbness. On the other hand, most cooling agents are oil-soluble and require solvents (such as ethanol and propylene glycol) for dissolution. Some solvents themselves may strip away the skin's natural oils, causing dryness and thus amplifying the irritation. The pH value of the formulation and other active ingredients (such as certain preservatives and fragrances) may also produce synergistic irritation.

[0006] Lack of dynamic responsiveness: The cooling intensity of existing cooling wipes is fixed and cannot respond to the user's actual usage scenario. For example, when sweating heavily after exercise, users want a stronger cooling sensation to cool down, but ordinary cooling wipes cannot provide this "on-demand" enhanced experience.

[0007] In view of the above problems, this invention is proposed. Summary of the Invention

[0008] To address the aforementioned technical problems, one of the objectives of this invention is to provide a wet wipe compound liquid with long-lasting cooling and secondary cooling sensations. Through a unique cooling agent composition and a specific preparation process, it can provide multiple cooling sensations, including immediate cooling, long-lasting cooling, and secondary cooling sensations triggered when exposed to sweat or moisture during use.

[0009] The second objective of this invention is to provide a method for preparing the above-mentioned wet wipe compound solution, which involves mixing a cooling agent composition in a specific ratio and integrating it into the wet wipe compound solution. The preparation process is simple and easy to implement.

[0010] A third objective of this invention is to provide the application of the above-mentioned wet wipe compound in the preparation of wet wipes.

[0011] To achieve the above objectives, the present invention adopts the following technical solution:

[0012] In a first aspect, the present invention provides a wet wipe compound liquid with long-lasting cooling sensation and secondary cooling sensation, which is prepared by weight from the following raw materials: 80-96 parts of solvent, 0.1-2 parts of cooling agent composition, 1-10 parts of humectant, 0.1-2 parts of solubilizer, and 0.1-5 parts of preservative.

[0013] In the above technical solution, by formulating a cooling agent composition in a specific ratio and integrating it into the wet wipe compound liquid, the problem of the cooling sensation of the cooling agent in the prior art being short-lived, singular, and unstable is solved.

[0014] As a preferred embodiment of the technical solution of the present invention, the wet wipe compound solution is prepared by means of the following raw materials in parts by weight: 90 parts solvent, 0.5 parts cooling agent composition, 1 part humectant, 0.8 parts solubilizer, and 0.8 parts preservative.

[0015] As a preferred embodiment of the technical solution of the present invention, the solvent is water;

[0016] The moisturizer is selected from one or both of aloe vera juice and glycerin;

[0017] The solubilizer is selected from one or more of PEG-40 hydrogenated castor oil, polyvinylpyrrolidone, and polysorbate-20;

[0018] The preservative is selected from one or both of octanoyl hydroxamic acid and phenoxyethanol.

[0019] As a preferred embodiment of the present invention, the cooling agent composition, in terms of a total mass fraction of 100%, is prepared from the following raw materials: 76-95.29% 1,3-propanediol, 2-9% methyl diisopropyl propionamide, 2-8.5% menthol carbamoyl ethylamine, 0.5-3.5% hydroxypropyl cellulose, 0.1-2% hydroxypropyl-β-cyclodextrin, 0.1-2% borneol, and 0.01-1% oil.

[0020] In the above technical solution, the preparation of multiple cooling agents through compound synergy and multi-encapsulation system can provide a stronger and longer-lasting cooling experience even when the total amount of cooling agent added is lower than that of conventional single cooling agent wipes, thereby avoiding the risk of skin irritation caused by high concentrations of added agents from the source.

[0021] As a further preferred embodiment of the technical solution of the present invention, the cooling agent composition is prepared from the following raw materials, based on a total mass fraction of 100%: 77-95% 1,3-propanediol, 3-8% methyl diisopropylpropionamide, 3-8% menthol alkylformyl ethylamine, 0.9-3% hydroxypropyl cellulose, 0.4-1.6% hydroxypropyl-β-cyclodextrin, 0.4-1.6% borneol, and 0.02-0.8% oil.

[0022] As a further preferred embodiment of the technical solution of the present invention, by way of example, the cooling agent composition is prepared from the following raw materials in a total mass fraction of 100%: 87.2% 1,3-propanediol, 6% methyl diisopropylpropionamide, 3.5% menthol alkylformyl ethylamine, 1.8% hydroxypropyl cellulose, 0.5% hydroxypropyl-β-cyclodextrin, 0.5% borneol, and 0.5% oil.

[0023] As a further preferred embodiment of the technical solution of the present invention, by way of example, the cooling agent composition is prepared from the following raw materials in a total mass fraction of 100%: 79.5% 1,3-propanediol, 8% methyl diisopropylpropionamide, 8% menthol alkylformyl ethylamine, 3% hydroxypropyl cellulose, 0.5% hydroxypropyl-β-cyclodextrin, 0.5% borneol, and 0.5% oil.

[0024] As a further preferred embodiment of the technical solution of the present invention, by way of example, the cooling agent composition is prepared from the following raw materials in a total mass fraction of 100%: 94% 1,3-propanediol, 2% methyl diisopropylpropionamide, 2% menthol alkyl ethylamine, 0.5% hydroxypropyl cellulose, 0.5% hydroxypropyl-β-cyclodextrin, 0.5% borneol, and 0.5% oil.

[0025] As a preferred embodiment of the present invention, the oil is selected from one or more of butylene glycol dioctanoic acid / didecanoate, isononyl isononanoate, and lemon eucalyptus oil. More preferably, the oil is butylene glycol dioctanoic acid / didecanoate. Butylene glycol dioctanoic acid / didecanoate can not only effectively dissolve components such as borneol in the core, but also is miscible with hydroxypropyl cellulose in the outer core, thereby forming a stable multi-layer encapsulation system.

[0026] As a preferred embodiment of the present invention, the hydroxypropyl cellulose is a highly substituted hydroxypropyl cellulose, and the hydroxypropyl content in the hydroxypropyl cellulose is 60-70%.

[0027] Correspondingly, the present invention also provides a method for preparing the above-mentioned cooling agent composition, comprising the following steps:

[0028] S1. Hydroxypropyl cellulose, hydroxypropyl-β-cyclodextrin, and 1,3-propanediol (part 1) are mixed in the specified proportions and then homogenized to obtain phase A.

[0029] S2. Dissolve borneol and oil in the second part of 1,3-propanediol, stir and process to obtain phase B;

[0030] S3. Add phase A obtained in step S1 to phase B obtained in step S2, stir and then homogenize to obtain phase C.

[0031] S4. Add methyl diisopropyl propionamide to phase C obtained in step S3, stir and then homogenize to obtain phase D;

[0032] S5. Menthaneformyl ethylamine is added to phase D, heated and stirred, and then homogenized. After the homogenization is completed, the mixture is cooled and filtered to obtain the cooling agent composition.

[0033] As a preferred embodiment of the technical solution of the present invention, in step S1, the temperature of the stirring and mixing treatment is 10~35℃, the rotation speed is 50~500rpm, and the treatment time is 60~120min; the rotation speed of the homogenization treatment is 1000~10000rpm, and the treatment time is 5~30min.

[0034] The mass ratio of the sum of the masses of hydroxypropyl cellulose and hydroxypropyl-β-cyclodextrin to the mass of 1,3-propanediol in Part I is 1:(10~20).

[0035] As a preferred embodiment of the technical solution of the present invention, in step S2, the stirring temperature is 40~65℃, the rotation speed is 10~60rpm, and the processing time is 10~60min.

[0036] As a preferred embodiment of the technical solution of the present invention, in step S3, the stirring temperature is 40~60℃ and the processing time is 30~120min; the homogenization speed is 1000~10000rpm and the processing time is 5~30min.

[0037] As a preferred embodiment of the technical solution of the present invention, in step S4, the stirring temperature is 75~90℃, the rotation speed is 50~500rpm, and the processing time is 30~120min; the homogenization speed is 1000~10000rpm, and the processing time is 5~30min.

[0038] In step S5, the heating and stirring temperature is 75~90℃, the rotation speed is 50~500rpm, and the processing time is 30~120min; the homogenization speed is 1000~10000rpm, and the processing time is 5~30min; the temperature is lowered to 20~40℃; and the filtration mesh size is 150~250 mesh.

[0039] Secondly, the present invention also provides a method for preparing the above-mentioned wet wipe compound solution, comprising the following steps:

[0040] (1) After mixing water, preservative and humectant, heat and stir to obtain phase a;

[0041] (2) After mixing the solubilizer and cooling agent composition, heat and stir to obtain phase b;

[0042] (3) Add phase b to phase a, heat and stir to obtain wet wipe compound solution.

[0043] As a preferred embodiment of the technical solution of the present invention, in step (1), the heating and stirring temperature is 45~60℃, the rotation speed is 20~500rpm, and the stirring time is 30~60min;

[0044] In step (2), the heating and stirring temperature is 50~70℃, the speed is 20~500rpm, and the stirring time is 10~60min;

[0045] In step (3), the heating and stirring temperature is 40~65℃, the speed is 30~120rpm, and the stirring time is 30~120min.

[0046] Thirdly, this invention also provides an application of the aforementioned wet wipe compound liquid in the preparation of wet wipes. The preparation of the aforementioned wet wipes can be carried out using existing technologies, such as application or soaking, and this invention does not limit the specific preparation method. The wet wipe product made based on the aforementioned wet wipe compound liquid can provide a three-stage cooling experience: the first stage is the immediate cooling sensation provided by the free cooling agent during wiping; the second stage is the lasting, mild cooling sensation provided by the slowly released cooling agent; and the third stage is the secondary burst of cooling sensation during use, generated by the release of a high concentration of cooling agent from the multiple cooling agent encapsulation system upon contact with sweat or water.

[0047] Compared with the prior art, the present invention has the following beneficial effects:

[0048] (1) The wet wipe compound liquid provided by the present invention, through a unique cooling agent composition and a specific preparation process, can provide multiple cooling experiences, including instant cooling, long-lasting cooling, and secondary cooling when it comes into contact with sweat or moisture during use.

[0049] (2) The wet wipes prepared based on the wet wipe compound provided by this invention can also bring a triple cooling experience, that is, to achieve a progressive, multi-layered cooling experience of "instant cooling → long-lasting cooling → secondary burst of cooling". In addition, it also has multiple uses, including:

[0050] Long-lasting and stable cooling sensation: The multi-layer encapsulation technology of the cooling agent greatly reduces the volatilization loss of the cooling agent during production and storage, ensuring the stability of the cooling effect throughout the product's shelf life and extending the cooling duration of a single use to more than 60 minutes.

[0051] Intelligent responsiveness: Based on a multi-encapsulation system of hydroxypropyl cellulose and hydroxypropyl cyclodextrin, the wet wipe compound can intelligently enhance the cooling sensation when the user sweats, meeting dynamic needs, and is especially suitable for sports, outdoor and other scenarios.

[0052] (3) The wet wipe compound solution provided by this invention uses a unique cooling agent composition that has excellent long-lasting cooling effect and significantly extends the duration of action. Through unique composition design and innovative preparation process, a stable multi-encapsulation system is formed, thereby enabling the cooling ingredients to have a long-lasting sustained-release effect. This composition can overcome the shortcomings of traditional single cooling agents with short duration of action. Specifically, this invention first encapsulates the cooling ingredients by selecting suitable oil phases to form a stable oil phase core, and then disperses the particles encapsulating the cooling ingredients in a protective system. Through a special process, micelles are formed to encapsulate the protective system and the cooling agent particles, which are then applied to an aqueous formulation. When the product is applied to the skin surface, the water evaporates, and the encapsulated shell forms a barrier to control the release of the cooling agent; after the carrier structure collapses, it disintegrates upon contact with water, and the cooling ingredients dissolved in the core are released a second time, producing a continuous cooling sensation.

[0053] (4) The wet wipe compound liquid provided by the present invention uses a unique cooling agent composition that can provide a gentle and comfortable cooling experience and avoid strong stimulation. Through scientific compounding, the "burst" and "duration" of the cooling sensation can be adjusted, avoiding the cold and stinging sensation caused by a single high-intensity cooling agent, making the cooling sensation more gentle, comfortable and natural, and easier for consumers to accept.

[0054] (5) The wet wipe compound solution provided by the present invention uses a unique cooling agent composition. The preparation process is simple, environmentally friendly, and conducive to industrial production. The preparation method avoids the complex microcapsule coating process. The reaction conditions are mild and the steps are simple. No special or expensive equipment is required. The production cost is low and the yield is high. It is very suitable for large-scale industrial production and promotion.

[0055] (6) The preparation method of the wet wipe compound liquid provided by the present invention involves mature and reliable processes, which are easy to scale up on existing wet wipe production lines. Attached Figure Description

[0056] Figure 1 This is a schematic diagram of the products obtained in Example 1 and Comparative Example 6.

[0057] Figure 2 This is a comparison chart of the test results of Example 1 and the control group in Test Example 1.

[0058] Figure 3 This is a comparison chart of the test results of Example 1 and Comparative Example 1 in Test Example 1.

[0059] Figure 4 This is a comparison chart of the test results of Example 1 and Comparative Example 2 in Test Example 1.

[0060] Figure 5 This is a comparison chart of the test results of Example 1 and Comparative Example 3 in Test Example 1.

[0061] Figure 6 This is a comparison chart of the test results of Example 1 and Comparative Example 4 in Test Example 1.

[0062] Figure 7 This is a comparison chart of the test results of Example 1 and Comparative Example 5 in Test Example 1.

[0063] Figure 8 This is a comparison chart of the test results of Example 1 and Comparative Example 7 in Test Example 1.

[0064] Figure 9 This is a comparison chart of the test results of Example 1 and the control group in Test Example 2.

[0065] Figure 10 This is a comparison chart of the test results of Comparative Example 1 and the control group in Test Example 2.

[0066] Figure 11 This is a comparison chart of the test results of Comparative Example 2 and the control group in Test Example 2.

[0067] Figure 12 This is a comparison chart of the test results of Comparative Example 7 and the control group in Test Example 2.

[0068] Figure 13 This is a comparison chart of the test results of Comparative Example 8 and the control group in Test Example 2.

[0069] Figure 14 This is the TME diagram for the product test in Example 1.

[0070] Figure 15 The TME diagram is for the product test in Comparative Example 7.

[0071] Figure 16 The TME diagram is for the test of product 8 in Comparative Example 8.

[0072] Figure 17 These are schematic diagrams of the products in Example 14 and Comparative Example 18.

[0073] Figure 18 This is a comparison chart of the test results of Example 14 and the control group in Test Example 4.

[0074] Figure 19 This is a comparison chart of the test results of Comparative Example 9 and the control group in Test Example 4.

[0075] Figure 20 This is a comparison chart of the test results of Comparative Example 10 and the control group in Test Example 4.

[0076] Figure 21 This is a comparison chart of the test results of Comparative Example 11 and the control group in Test Example 4.

[0077] Figure 22 This is a comparison chart of the test results of Comparative Example 14 and the control group in Test Example 4.

[0078] Figure 23 This is a comparison chart of the test results of Comparative Example 15 and the control group in Test Example 4.

[0079] Figure 24 This is a comparison chart of the test results of Example 14 and the control group in Test Example 5.

[0080] Figure 25 This is a comparison chart of the test results of Comparative Example 12 and the control group in Test Example 5.

[0081] Figure 26 This is a comparison chart of the test results of Comparative Example 13 and the control group in Test Example 5.

[0082] Figure 27 This is a comparison chart showing the test results of the stimulation sensation in the embodiment and the comparative example in Test Example 6.

[0083] Figure 28 This is a comparison chart showing the test results of the cooling sensation in the examples and comparative examples in Test Example 6.

[0084] Figure 29 This is the TME diagram for the product test in Test Example 7. Detailed Implementation

[0085] The technical solutions of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.

[0086] Unless otherwise specified, all raw and auxiliary materials used in this invention are readily available and their specifications comply with national pharmaceutical standards.

[0087] As partly exemplary, information on some of the substances used in the embodiments of the present invention is as follows:

[0088] Aloe vera juice, purchased from Wanlv Company;

[0089] Phenoxyethanol, purchased from Thor;

[0090] PEG-40 hydrogenated castor oil, purchased from BASF;

[0091] 1,3-Propanediol: purchased from DuPont;

[0092] Hydroxypropyl cellulose was purchased from Jinan Beiding New Material Technology Co., Ltd.

[0093] Hydroxypropyl-β-cyclodextrin was purchased from Shandong Jiake Biotechnology Co., Ltd.

[0094] Borneol was purchased from Xi'an Weisbo Biotechnology Co., Ltd.

[0095] Methyl diisopropyl propionamide was purchased from Wuhan Kemike Biomedical Technology Co., Ltd.

[0096] Menthylcarbamate was purchased from Wuhan Kemic Biomedical Technology Co., Ltd.

[0097] Butylene glycol dioctanoate / didecanoate, purchased from Oleochemicals, Germany;

[0098] Lemon eucalyptus oil, purchased from Xi'an Weisbo Biotechnology Co., Ltd.

[0099] Isonononyl isononanoate was purchased from Croda Chemicals (Shanghai) Co., Ltd.

[0100] Example 1

[0101] A cooling agent composition, prepared from the following raw materials in 100% by weight: 87.2% 1,3-propanediol, 6% methyl diisopropylpropionamide, 3.5% menthol alkyl ethylamine, 1.8% hydroxypropyl cellulose, 0.5% hydroxypropyl-β-cyclodextrin, 0.5% borneol, and 0.5% butylene glycol dioctanoic acid / didecanoic acid ester.

[0102] In this embodiment, a method for preparing the above-mentioned cooling agent composition is also provided, comprising the following steps:

[0103] S1. Hydroxypropyl cellulose, hydroxypropyl-β-cyclodextrin, and 1,3-propanediol (the mass ratio of hydroxypropyl cellulose, hydroxypropyl-β-cyclodextrin, and 1,3-propanediol is 1:11) are stirred and mixed according to the formula (30℃, 100rpm, 90min), and then homogenized (8000rpm, 5min) to obtain phase A.

[0104] S2. Dissolve borneol and butylene glycol dioctanoic acid / didecanoate in the remaining 1,3-propanediol, and stir (60℃, 100rpm, 30min) to obtain phase B;

[0105] S3. Add phase A obtained in step S1 to phase B obtained in step S2, stir (60℃, 60min), and then homogenize (8000rpm, 5min) to obtain phase C.

[0106] S4. Add methyl diisopropyl propionamide to phase C obtained in step S3, stir (85℃, 50 rpm, 30 min), and then homogenize (8000 rpm, 30 min) to obtain phase D.

[0107] S5. Menthaneformyl ethylamine is added to phase D, heated and stirred (85℃, 50 rpm, 30 min), and then homogenized (8000 rpm, 30 min). After the homogenization is completed, the mixture is cooled to 40℃ and filtered through a 200-mesh filter to obtain the cooling agent composition.

[0108] Example 2

[0109] A cooling agent composition, prepared from the following raw materials in 100% by weight: 79.5% 1,3-propanediol, 8% methyl diisopropylpropionamide, 8% menthol alkyl ethylamine, 3% hydroxypropyl cellulose, 0.5% hydroxypropyl-β-cyclodextrin, 0.5% borneol, and 0.5% butylene glycol dioctanoic acid / didecanoic acid ester.

[0110] In this embodiment, a method for preparing the above-mentioned cooling agent composition is also provided, comprising the following steps:

[0111] S1. Hydroxypropyl cellulose, hydroxypropyl-β-cyclodextrin, and 1,3-propanediol (the mass ratio of hydroxypropyl cellulose, hydroxypropyl-β-cyclodextrin, and 1,3-propanediol is 1:11) are stirred and mixed according to the formula (30℃, 100rpm, 90min), and then homogenized (8000rpm, 5min) to obtain phase A.

[0112] S2. Dissolve borneol and butylene glycol dioctanoic acid / didecanoate in the remaining 1,3-propanediol, and stir (60℃, 100rpm, 30min) to obtain phase B;

[0113] S3. Add phase A obtained in step S1 to phase B obtained in step S2, stir (60℃, 60min), and then homogenize (8000rpm, 5min) to obtain phase C.

[0114] S4. Add methyl diisopropyl propionamide to phase C obtained in step S3, stir (85℃, 50 rpm, 30 min), and then homogenize (8000 rpm, 30 min) to obtain phase D.

[0115] S5. Menthaneformyl ethylamine is added to phase D, heated and stirred (85℃, 50 rpm, 30 min), and then homogenized (8000 rpm, 30 min). After the homogenization is completed, the mixture is cooled to 40℃ and filtered through a 200-mesh filter to obtain the cooling agent composition.

[0116] Example 3

[0117] A cooling agent composition, prepared from the following raw materials in 100% by weight: 94% 1,3-propanediol, 2% methyl diisopropylpropionamide, 2% menthol alkyl ethylamine, 0.5% hydroxypropyl cellulose, 0.5% hydroxypropyl-β-cyclodextrin, 0.5% borneol, and 0.5% butylene glycol dioctanoic acid / didecanoic acid ester.

[0118] In this embodiment, a method for preparing the above-mentioned cooling agent composition is also provided, comprising the following steps:

[0119] S1. Hydroxypropyl cellulose, hydroxypropyl-β-cyclodextrin, and 1,3-propanediol (the mass ratio of hydroxypropyl cellulose, hydroxypropyl-β-cyclodextrin, and 1,3-propanediol is 1:11) are stirred and mixed according to the formula (30℃, 100rpm, 90min), and then homogenized (8000rpm, 5min) to obtain phase A.

[0120] S2. Dissolve borneol and butylene glycol dioctanoic acid / didecanoate in the remaining 1,3-propanediol, and stir (60℃, 100rpm, 30min) to obtain phase B;

[0121] S3. Add phase A obtained in step S1 to phase B obtained in step S2, stir (60℃, 60min), and then homogenize (8000rpm, 5min) to obtain phase C.

[0122] S4. Add methyl diisopropyl propionamide to phase C obtained in step S3, stir (85℃, 50 rpm, 30 min), and then homogenize (8000 rpm, 30 min) to obtain phase D.

[0123] S5. Menthaneformyl ethylamine is added to phase D, heated and stirred (85℃, 50 rpm, 30 min), and then homogenized (8000 rpm, 30 min). After the homogenization is completed, the mixture is cooled to 40℃ and filtered through a 200-mesh filter to obtain the cooling agent composition.

[0124] Example 4

[0125] A cooling agent composition, prepared from the following raw materials in 100% by weight: 85.2% 1,3-propanediol, 6% methyl diisopropylpropionamide, 3.5% menthol alkyl ethylamine, 1.8% hydroxypropyl cellulose, 0.5% hydroxypropyl-β-cyclodextrin, 2% borneol, and 1% butylene glycol dioctanoic acid / didecanoate.

[0126] In this embodiment, a method for preparing the above-mentioned cooling agent composition is also provided, comprising the following steps:

[0127] S1. Hydroxypropyl cellulose, hydroxypropyl-β-cyclodextrin, and 1,3-propanediol (the mass ratio of hydroxypropyl cellulose, hydroxypropyl-β-cyclodextrin, and 1,3-propanediol is 1:11) are stirred and mixed according to the formula (30℃, 100rpm, 90min), and then homogenized (8000rpm, 5min) to obtain phase A.

[0128] S2. Dissolve borneol and butylene glycol dioctanoic acid / didecanoate in the remaining 1,3-propanediol, and stir (60℃, 100rpm, 30min) to obtain phase B;

[0129] S3. Add phase A obtained in step S1 to phase B obtained in step S2, stir (60℃, 60min), and then homogenize (8000rpm, 5min) to obtain phase C.

[0130] S4. Add methyl diisopropyl propionamide to phase C obtained in step S3, stir (85℃, 50 rpm, 30 min), and then homogenize (8000 rpm, 30 min) to obtain phase D.

[0131] S5. Menthaneformyl ethylamine is added to phase D, heated and stirred (85℃, 50 rpm, 30 min), and then homogenized (8000 rpm, 30 min). After the homogenization is completed, the mixture is cooled to 40℃ and filtered through a 200-mesh filter to obtain the cooling agent composition.

[0132] Example 5

[0133] A cooling agent composition, prepared from the following raw materials in 100% by weight: 88.09% 1,3-propanediol, 6% methyl diisopropylpropionamide, 3.5% menthol ethylcarbamate, 1.8% hydroxypropyl cellulose, 0.5% hydroxypropyl-β-cyclodextrin, 0.1% borneol, and 0.01% lemon eucalyptus oil.

[0134] In this embodiment, a method for preparing the above-mentioned cooling agent composition is also provided, comprising the following steps:

[0135] S1. Hydroxypropyl cellulose, hydroxypropyl-β-cyclodextrin, and 1,3-propanediol (the mass ratio of hydroxypropyl cellulose, hydroxypropyl-β-cyclodextrin, and 1,3-propanediol is 1:11) are stirred and mixed according to the formula (30℃, 100rpm, 90min), and then homogenized (8000rpm, 5min) to obtain phase A.

[0136] S2. Dissolve borneol and lemon eucalyptus oil in the remaining 1,3-propanediol, and stir (60℃, 100rpm, 30min) to obtain phase B;

[0137] S3. Add phase A obtained in step S1 to phase B obtained in step S2, stir (60℃, 60min), and then homogenize (8000rpm, 5min) to obtain phase C.

[0138] S4. Add methyl diisopropyl propionamide to phase C obtained in step S3, stir (85℃, 50 rpm, 30 min), and then homogenize (8000 rpm, 30 min) to obtain phase D.

[0139] S5. Menthaneformyl ethylamine is added to phase D, heated and stirred (85℃, 50 rpm, 30 min), and then homogenized (8000 rpm, 30 min). After the homogenization is completed, the mixture is cooled to 40℃ and filtered through a 200-mesh filter to obtain the cooling agent composition.

[0140] Example 6

[0141] A cooling agent composition, prepared from the following raw materials in 100% by weight: 87.2% 1,3-propanediol, 6% methyl diisopropylpropionamide, 3.5% menthol alkyl ethylamine, 1.8% hydroxypropyl cellulose, 0.5% hydroxypropyl-β-cyclodextrin, 0.5% borneol, and 0.5% butylene glycol dioctanoic acid / didecanoic acid ester.

[0142] In this embodiment, a method for preparing the above-mentioned cooling agent composition is also provided, comprising the following steps:

[0143] S1. Hydroxypropyl cellulose, hydroxypropyl-β-cyclodextrin, and 1,3-propanediol (the mass ratio of hydroxypropyl cellulose, hydroxypropyl-β-cyclodextrin, and 1,3-propanediol is 1:20) are stirred and mixed according to the formula (30℃, 100rpm, 90min), and then homogenized (8000rpm, 5min) to obtain phase A.

[0144] S2. Dissolve borneol and butylene glycol dioctanoic acid / didecanoate in the remaining 1,3-propanediol, and stir (60℃, 100rpm, 30min) to obtain phase B;

[0145] S3. Add phase A obtained in step S1 to phase B obtained in step S2, stir (60℃, 60min), and then homogenize (8000rpm, 5min) to obtain phase C.

[0146] S4. Add methyl diisopropyl propionamide to phase C obtained in step S3, stir (85℃, 50 rpm, 30 min), and then homogenize (8000 rpm, 30 min) to obtain phase D.

[0147] S5. Menthaneformyl ethylamine is added to phase D, heated and stirred (85℃, 50 rpm, 30 min), and then homogenized (8000 rpm, 30 min). After the homogenization is completed, the mixture is cooled to 40℃ and filtered through a 200-mesh filter to obtain the cooling agent composition.

[0148] Example 7

[0149] A cooling agent composition, prepared from the following raw materials in 100% by weight: 87.2% 1,3-propanediol, 6% methyl diisopropylpropionamide, 3.5% menthol alkyl ethylamine, 1.8% hydroxypropyl cellulose, 0.5% hydroxypropyl-β-cyclodextrin, 0.5% borneol, and 0.5% butylene glycol dioctanoic acid / didecanoic acid ester.

[0150] In this embodiment, a method for preparing the above-mentioned cooling agent composition is also provided, comprising the following steps:

[0151] S1. Hydroxypropyl cellulose, hydroxypropyl-β-cyclodextrin, and 1,3-propanediol (the mass ratio of hydroxypropyl cellulose, hydroxypropyl-β-cyclodextrin, and 1,3-propanediol is 1:11) are stirred and mixed according to the formula (30℃, 100rpm, 90min), and then homogenized (8000rpm, 5min) to obtain phase A.

[0152] S2. Dissolve borneol and butylene glycol dioctanoic acid / didecanoate in the remaining 1,3-propanediol, and stir (40℃, 100rpm, 60min) to obtain phase B;

[0153] S3. Add phase A obtained in step S1 to phase B obtained in step S2, stir (60℃, 60min), and then homogenize (8000rpm, 5min) to obtain phase C.

[0154] S4. Add methyl diisopropyl propionamide to phase C obtained in step S3, stir (85℃, 50 rpm, 30 min), and then homogenize (8000 rpm, 30 min) to obtain phase D.

[0155] S5. Menthaneformyl ethylamine is added to phase D, heated and stirred (85℃, 50 rpm, 30 min), and then homogenized (8000 rpm, 30 min). After the homogenization is completed, the mixture is cooled to 40℃ and filtered through a 200-mesh filter to obtain the cooling agent composition.

[0156] Example 8

[0157] A cooling agent composition, prepared from the following raw materials in 100% by weight: 87.2% 1,3-propanediol, 6% methyl diisopropylpropionamide, 3.5% menthol alkyl ethylamine, 1.8% hydroxypropyl cellulose, 0.5% hydroxypropyl-β-cyclodextrin, 0.5% borneol, and 0.5% butylene glycol dioctanoic acid / didecanoic acid ester.

[0158] In this embodiment, a method for preparing the above-mentioned cooling agent composition is also provided, comprising the following steps:

[0159] S1. Hydroxypropyl cellulose, hydroxypropyl-β-cyclodextrin, and 1,3-propanediol (the mass ratio of hydroxypropyl cellulose, hydroxypropyl-β-cyclodextrin, and 1,3-propanediol is 1:11) are stirred and mixed according to the formula (30℃, 100rpm, 90min), and then homogenized (8000rpm, 5min) to obtain phase A.

[0160] S2. Dissolve borneol and butylene glycol dioctanoic acid / didecanoate in the remaining 1,3-propanediol, and stir (60℃, 100rpm, 30min) to obtain phase B;

[0161] S3. Add phase A obtained in step S1 to phase B obtained in step S2, stir (40℃, 120min), and then homogenize (8000rpm, 5min) to obtain phase C.

[0162] S4. Add methyl diisopropyl propionamide to phase C obtained in step S3, stir (85℃, 50 rpm, 30 min), and then homogenize (8000 rpm, 30 min) to obtain phase D.

[0163] S5. Menthaneformyl ethylamine is added to phase D, heated and stirred (85℃, 50 rpm, 30 min), and then homogenized (8000 rpm, 30 min). After the homogenization is completed, the mixture is cooled to 40℃ and filtered through a 200-mesh filter to obtain the cooling agent composition.

[0164] Example 9

[0165] A cooling agent composition, prepared from the following raw materials in 100% by weight: 87.2% 1,3-propanediol, 6% methyl diisopropylpropionamide, 3.5% menthol alkyl ethylamine, 1.8% hydroxypropyl cellulose, 0.5% hydroxypropyl-β-cyclodextrin, 0.5% borneol, and 0.5% butylene glycol dioctanoic acid / didecanoic acid ester.

[0166] In this embodiment, a method for preparing the above-mentioned cooling agent composition is also provided, comprising the following steps:

[0167] S1. Hydroxypropyl cellulose, hydroxypropyl-β-cyclodextrin, and 1,3-propanediol (the mass ratio of hydroxypropyl cellulose, hydroxypropyl-β-cyclodextrin, and 1,3-propanediol is 1:11) are stirred and mixed according to the formula (30℃, 100rpm, 90min), and then homogenized (8000rpm, 5min) to obtain phase A.

[0168] S2. Dissolve borneol and butylene glycol dioctanoic acid / didecanoate in the remaining 1,3-propanediol, and stir (60℃, 100rpm, 30min) to obtain phase B;

[0169] S3. Add phase A obtained in step S1 to phase B obtained in step S2, stir (60℃, 60min), and then homogenize (8000rpm, 5min) to obtain phase C.

[0170] S4. Add methyl diisopropyl propionamide to the C phase obtained in step S3, stir (90℃, 50 rpm, 30 min), and then homogenize (8000 rpm, 30 min) to obtain the D phase.

[0171] S5. Menthaneformyl ethylamine is added to phase D, heated and stirred (85℃, 50 rpm, 30 min), and then homogenized (8000 rpm, 30 min). After the homogenization is completed, the mixture is cooled to 40℃ and filtered through a 200-mesh filter to obtain the cooling agent composition.

[0172] Example 10

[0173] A cooling agent composition, prepared from the following raw materials in 100% by weight: 87.2% 1,3-propanediol, 6% methyl diisopropylpropionamide, 3.5% menthol alkyl ethylamine, 1.8% hydroxypropyl cellulose, 0.5% hydroxypropyl-β-cyclodextrin, 0.5% borneol, and 0.5% butylene glycol dioctanoic acid / didecanoic acid ester.

[0174] In this embodiment, a method for preparing the above-mentioned cooling agent composition is also provided, comprising the following steps:

[0175] S1. Hydroxypropyl cellulose, hydroxypropyl-β-cyclodextrin, and 1,3-propanediol (the mass ratio of hydroxypropyl cellulose, hydroxypropyl-β-cyclodextrin, and 1,3-propanediol is 1:11) are stirred and mixed according to the formula (30℃, 100rpm, 90min), and then homogenized (8000rpm, 5min) to obtain phase A.

[0176] S2. Dissolve borneol and butylene glycol dioctanoic acid / didecanoate in the remaining 1,3-propanediol, and stir (60℃, 100rpm, 30min) to obtain phase B;

[0177] S3. Add phase A obtained in step S1 to phase B obtained in step S2, stir (60℃, 60min), and then homogenize (8000rpm, 5min) to obtain phase C.

[0178] S4. Add methyl diisopropyl propionamide to the C phase obtained in step S3, stir (85℃, 50 rpm, 30 min), and then homogenize (3000 rpm, 40 min) to obtain the D phase.

[0179] S5. Menthaneformyl ethylamine is added to phase D, heated and stirred (85℃, 50 rpm, 30 min), and then homogenized (8000 rpm, 30 min). After the homogenization is completed, the mixture is cooled to 40℃ and filtered through a 200-mesh filter to obtain the cooling agent composition.

[0180] Example 11

[0181] A cooling agent composition, prepared from the following raw materials in 100% by weight: 87.2% 1,3-propanediol, 6% methyl diisopropylpropionamide, 3.5% menthol alkyl ethylamine, 1.8% hydroxypropyl cellulose, 0.5% hydroxypropyl-β-cyclodextrin, 0.5% borneol, and 0.5% butylene glycol dioctanoic acid / didecanoic acid ester.

[0182] In this embodiment, a method for preparing the above-mentioned cooling agent composition is also provided, comprising the following steps:

[0183] S1. Hydroxypropyl cellulose, hydroxypropyl-β-cyclodextrin, and 1,3-propanediol (the mass ratio of hydroxypropyl cellulose, hydroxypropyl-β-cyclodextrin, and 1,3-propanediol is 1:11) are stirred and mixed according to the formula (30℃, 100rpm, 90min), and then homogenized (8000rpm, 5min) to obtain phase A.

[0184] S2. Dissolve borneol and butylene glycol dioctanoic acid / didecanoate in the remaining 1,3-propanediol, and stir (60℃, 100rpm, 30min) to obtain phase B;

[0185] S3. Add phase A obtained in step S1 to phase B obtained in step S2, stir (60℃, 60min), and then homogenize (8000rpm, 5min) to obtain phase C.

[0186] S4. Add methyl diisopropyl propionamide to phase C obtained in step S3, stir (85℃, 50 rpm, 30 min), and then homogenize (8000 rpm, 30 min) to obtain phase D.

[0187] S5. Menthanecarbamate was added to phase D, heated and stirred (90℃, 50 rpm, 40 min), and then homogenized (8000 rpm, 30 min). After homogenization, the mixture was cooled to 40℃ and filtered through a 200-mesh filter to obtain the cooling agent composition.

[0188] Example 12

[0189] A cooling agent composition, prepared from the following raw materials in 100% by weight: 87.2% 1,3-propanediol, 6% methyl diisopropylpropionamide, 3.5% menthol alkyl ethylamine, 1.8% hydroxypropyl cellulose, 0.5% hydroxypropyl-β-cyclodextrin, 0.5% borneol, and 0.5% butylene glycol dioctanoic acid / didecanoic acid ester.

[0190] In this embodiment, a method for preparing the above-mentioned cooling agent composition is also provided, comprising the following steps:

[0191] S1. Hydroxypropyl cellulose, hydroxypropyl-β-cyclodextrin, and 1,3-propanediol (the mass ratio of hydroxypropyl cellulose, hydroxypropyl-β-cyclodextrin, and 1,3-propanediol is 1:11) are stirred and mixed according to the formula (30℃, 100rpm, 90min), and then homogenized (8000rpm, 5min) to obtain phase A.

[0192] S2. Dissolve borneol and butylene glycol dioctanoic acid / didecanoate in the remaining 1,3-propanediol, and stir (60℃, 100rpm, 30min) to obtain phase B;

[0193] S3. Add phase A obtained in step S1 to phase B obtained in step S2, stir (60℃, 60min), and then homogenize (8000rpm, 5min) to obtain phase C.

[0194] S4. Add methyl diisopropyl propionamide to phase C obtained in step S3, stir (85℃, 50 rpm, 30 min), and then homogenize (8000 rpm, 30 min) to obtain phase D.

[0195] S5. Menthanecarbamate was added to phase D, heated and stirred (85°C, 50 rpm, 30 min), and then homogenized (3000 rpm, 35 min). After homogenization, the mixture was cooled to 40°C and filtered through a 200-mesh filter to obtain the cooling agent composition.

[0196] Example 13

[0197] A cooling agent composition, prepared from the following raw materials in 100% by weight: 94% 1,3-propanediol, 2% methyl diisopropylpropionamide, 2% menthol alkyl ethylamine, 0.5% hydroxypropyl cellulose, 0.5% hydroxypropyl-β-cyclodextrin, 0.5% borneol, and 0.5% isononyl isononanoate.

[0198] In this embodiment, a method for preparing the above-mentioned cooling agent composition is also provided, comprising the following steps:

[0199] S1. Hydroxypropyl cellulose, hydroxypropyl-β-cyclodextrin, and 1,3-propanediol (the mass ratio of hydroxypropyl cellulose, hydroxypropyl-β-cyclodextrin, and 1,3-propanediol is 1:11) are stirred and mixed according to the formula (30℃, 100rpm, 90min), and then homogenized (8000rpm, 5min) to obtain phase A.

[0200] S2. Dissolve borneol and isononyl isononanoate in the remaining 1,3-propanediol, and stir (60℃, 100rpm, 30min) to obtain phase B;

[0201] S3. Add phase A obtained in step S1 to phase B obtained in step S2, stir (60℃, 60min), and then homogenize (8000rpm, 5min) to obtain phase C.

[0202] S4. Add methyl diisopropyl propionamide to phase C obtained in step S3, stir (85℃, 50 rpm, 30 min), and then homogenize (8000 rpm, 30 min) to obtain phase D.

[0203] S5. Menthaneformyl ethylamine is added to phase D, heated and stirred (85℃, 50 rpm, 30 min), and then homogenized (8000 rpm, 30 min). After the homogenization is completed, the mixture is cooled to 40℃ and filtered through a 200-mesh filter to obtain the cooling agent composition.

[0204] Example 14

[0205] A method for preparing a wet wipe compound solution includes the following steps:

[0206] (1) Mix water (excluding other substances), 0.8 wt% of preservative (phenoxyethanol) and 1 wt% of humectant (aloe vera juice) of the final product, and heat and stir (50℃, 100 rpm, 30 min) to obtain phase a;

[0207] (2) Mix 0.8 wt% of the final product mass of solubilizer (PEG-40 hydrogenated castor oil) and 0.5 wt% of the final product mass of cooling agent composition (prepared in Example 1), and then heat and stir (50°C, 100 rpm, 15 min) to obtain phase b;

[0208] (3) Add phase b to phase a, heat and stir (50℃, 100rpm, 60min) to obtain the wet wipe compound solution.

[0209] Example 15

[0210] A method for preparing a wet wipe compound solution includes the following steps:

[0211] (1) Mix water (excluding other substances), 0.8 wt% of preservative (phenoxyethanol) and 1 wt% of humectant (aloe vera juice) of the final product, and heat and stir (50℃, 100 rpm, 30 min) to obtain phase a;

[0212] (2) Mix 1.2 wt% of the final product mass of solubilizer (PEG-40 hydrogenated castor oil) and 0.8 wt% of the final product mass of cooling agent composition (prepared in Example 1), and then heat and stir (50°C, 100 rpm, 15 min) to obtain phase b;

[0213] (3) Add phase b to phase a, heat and stir (50℃, 100rpm, 60min) to obtain the wet wipe compound solution.

[0214] Example 16

[0215] A method for preparing a wet wipe compound solution includes the following steps:

[0216] (1) Mix water (excluding other substances), 0.8 wt% of preservative (phenoxyethanol) and 1 wt% of humectant (aloe vera juice) of the final product, and heat and stir (50℃, 100 rpm, 30 min) to obtain phase a;

[0217] (2) Mix 0.1 wt% of the final product mass of solubilizer (PEG-40 hydrogenated castor oil) and 0.1 wt% of the final product mass of cooling agent composition (prepared in Example 1), and then heat and stir (50°C, 100 rpm, 15 min) to obtain phase b;

[0218] (3) Add phase b to phase a, heat and stir (50℃, 100rpm, 60min) to obtain the wet wipe compound solution.

[0219] Example 17

[0220] A method for preparing a wet wipe compound solution includes the following steps:

[0221] (1) Mix water (excluding other substances), 0.8 wt% of preservative (phenoxyethanol) and 10 wt% of humectant (aloe vera juice) of the final product, and heat and stir (50℃, 100 rpm, 30 min) to obtain phase a;

[0222] (2) Mix 0.8 wt% of the final product mass of solubilizer (PEG-40 hydrogenated castor oil) and 0.5 wt% of the final product mass of cooling agent composition (prepared in Example 1), and then heat and stir (50°C, 100 rpm, 15 min) to obtain phase b;

[0223] (3) Add phase b to phase a, heat and stir (50℃, 100rpm, 60min) to obtain the wet wipe compound solution.

[0224] Example 18

[0225] A method for preparing a wet wipe compound solution includes the following steps:

[0226] (1) Mix water (excluding other substances), 0.8 wt% of preservative (phenoxyethanol) and 1 wt% of humectant (aloe vera juice) of the final product, and heat and stir (50℃, 100 rpm, 30 min) to obtain phase a;

[0227] (2) Mix 0.8 wt% of the final product mass of solubilizer (PEG-40 hydrogenated castor oil) and 0.5 wt% of the final product mass of cooling agent composition (prepared in Example 3), and then heat and stir (50°C, 100 rpm, 15 min) to obtain phase b;

[0228] (3) Add phase b to phase a, heat and stir (50℃, 100rpm, 60min) to obtain the wet wipe compound solution.

[0229] Example 19

[0230] A method for preparing a wet wipe compound solution includes the following steps:

[0231] (1) Mix water (excluding other substances), 0.8 wt% of preservative (phenoxyethanol) and 1 wt% of humectant (aloe vera juice) of the final product, and heat and stir (50℃, 100 rpm, 30 min) to obtain phase a;

[0232] (2) Mix 0.8 wt% of the final product mass of solubilizer (PEG-40 hydrogenated castor oil) and 0.5 wt% of the final product mass of cooling agent composition (prepared in Example 4), and then heat and stir (50°C, 100 rpm, 15 min) to obtain phase b;

[0233] (3) Add phase b to phase a, heat and stir (50℃, 100rpm, 60min) to obtain the wet wipe compound solution.

[0234] Comparative Example 1

[0235] Compared to Example 1, the use of hydroxypropyl cellulose was omitted, but everything else remained the same, with corresponding adjustments made to the preparation process.

[0236] Comparative Example 2

[0237] Compared with Example 1, the use of hydroxypropyl-β-cyclodextrin was omitted, but everything else was the same, and the preparation process was adjusted accordingly.

[0238] Comparative Example 3

[0239] Compared with Example 1, the use of butanediol dioctanoic acid / didecanoic acid ester was omitted, while the rest remained the same, with corresponding adjustments made to the preparation process.

[0240] Comparative Example 4

[0241] Compared with Example 1, the use of methyl diisopropyl propionamide was omitted, but everything else was the same, and the preparation process was adjusted accordingly.

[0242] Comparative Example 5

[0243] Compared with Example 1, the use of menthol carbamoyl ethylamine was omitted, but everything else was the same, with the preparation process adjusted accordingly.

[0244] Comparative Example 6

[0245] Compared with Example 1, the dissolution temperature for preparing phase A was adjusted to 60°C, and the rest was the same as in Example 1.

[0246] The A phase prepared in Example 1 is as follows Figure 1 The left image shows a uniform pre-dissolved state with no large particles. In Comparative Example 6, high-temperature mixing during the preparation of phase A resulted in ineffective swelling of hydroxypropyl cellulose, leading to the appearance of undissolved white lumps in the material (such as...). Figure 1(See right figure). This has a significant impact on subsequent processes and the appearance of the final product, and it cannot pass through 200-mesh filter cloth during filtration, which greatly affects the production yield.

[0247] Comparative Example 7

[0248] Compared with Example 1, the temperature was adjusted to 60°C after adding methyl diisopropyl propionamide and menthol carbamoyl ethylamine, and the rest was the same as in Example 1.

[0249] Comparative Example 8

[0250] A cooling agent composition, prepared from the following raw materials in 100% by weight: 87.2% 1,3-propanediol, 6% methyl diisopropylpropionamide, 3.5% menthol alkyl ethylamine, 1.8% hydroxypropyl cellulose, 0.5% hydroxypropyl-β-cyclodextrin, 0.5% borneol, and 0.5% butylene glycol dioctanoic acid / didecanoic acid ester.

[0251] This comparative example also provides a method for preparing the above-mentioned cooling agent composition, comprising the following steps:

[0252] Methyl diisopropylpropionamide, menthol carbamoyl ethylamine, hydroxypropyl cellulose, hydroxypropyl-β-cyclodextrin, borneol, and butylene glycol dioctanoic acid / didecanoic acid ester were added to 1,3-propanediol, stirred at 65°C for 60 min, homogenized at 8000 rpm for 10 min, and then cooled to 40°C.

[0253] Comparative Example 9

[0254] A method for preparing a wet wipe compound solution includes the following steps:

[0255] (1) Mix water (excluding other substances), 0.8 wt% of preservative (phenoxyethanol) and 1 wt% of humectant (aloe vera juice) of the final product, and heat and stir (50℃, 100 rpm, 30 min) to obtain phase a;

[0256] (2) Mix 0.8 wt% of the final product mass of solubilizer (PEG-40 hydrogenated castor oil) and 0.05 wt% of the final product mass of menthol, and then heat and stir (50℃, 100 rpm, 15 min) to obtain phase b;

[0257] (3) Add phase b to phase a, heat and stir (50℃, 100rpm, 60min) to obtain the wet wipe compound solution.

[0258] Comparative Example 10

[0259] A method for preparing a wet wipe compound solution includes the following steps:

[0260] (1) Mix water (excluding other substances), 0.8 wt% of preservative (phenoxyethanol) and 1 wt% of humectant (aloe vera juice) of the final product, and heat and stir (50℃, 100 rpm, 30 min) to obtain phase a;

[0261] (2) Mix 0.8 wt% of the final product mass of solubilizer (PEG-40 hydrogenated castor oil) and 0.05 wt% of the final product mass of methyl diisopropyl propionamide, and then heat and stir (50℃, 100 rpm, 15 min) to obtain phase b;

[0262] (3) Add phase b to phase a, heat and stir (50℃, 100rpm, 60min) to obtain the wet wipe compound solution.

[0263] Comparative Example 11

[0264] A method for preparing a wet wipe compound solution includes the following steps:

[0265] (1) Mix water (excluding other substances), 0.8 wt% of preservative (phenoxyethanol) and 1 wt% of humectant (aloe vera juice) of the final product, and heat and stir (50℃, 100 rpm, 30 min) to obtain phase a;

[0266] (2) Mix 0.8 wt% of the final product mass of solubilizer (PEG-40 hydrogenated castor oil) and 0.05 wt% of the final product mass of menthol carbamoyl ethylamine, and then heat and stir (50℃, 100 rpm, 15 min) to obtain phase b;

[0267] (3) Add phase b to phase a, heat and stir (50℃, 100rpm, 60min) to obtain the wet wipe compound solution.

[0268] Comparative Example 12

[0269] A method for preparing a wet wipe compound solution includes the following steps:

[0270] (1) Mix water (excluding other substances), 0.8 wt% of preservative (phenoxyethanol) and 1 wt% of humectant (aloe vera juice) of the final product, and heat and stir (50℃, 100 rpm, 30 min) to obtain phase a;

[0271] (2) Mix 0.8 wt% of the final product mass of solubilizer (PEG-40 hydrogenated castor oil) and 0.5 wt% of the final product mass of methyl diisopropyl propionamide, and then heat and stir (50℃, 100 rpm, 15 min) to obtain phase b;

[0272] (3) Add phase b to phase a, heat and stir (50℃, 100rpm, 60min) to obtain the wet wipe compound solution.

[0273] Comparative Example 13

[0274] A method for preparing a wet wipe compound solution includes the following steps:

[0275] (1) Mix water (excluding other substances), 0.8 wt% of preservative (phenoxyethanol) and 1 wt% of humectant (aloe vera juice) of the final product, and heat and stir (50℃, 100 rpm, 30 min) to obtain phase a;

[0276] (2) Mix 0.8 wt% of the final product mass of solubilizer (PEG-40 hydrogenated castor oil) and 0.5 wt% of the final product mass of menthol carbamoyl ethylamine, and then heat and stir (50℃, 100 rpm, 15 min) to obtain phase b;

[0277] (3) Add phase b to phase a, heat and stir (50℃, 100rpm, 60min) to obtain the wet wipe compound solution.

[0278] Comparative Example 14

[0279] A method for preparing a wet wipe compound solution includes the following steps:

[0280] (1) Mix water (excluding other substances), 0.8 wt% of preservative (phenoxyethanol) and 1 wt% of humectant (aloe vera juice) of the final product, and heat and stir (50℃, 100 rpm, 30 min) to obtain phase a;

[0281] (2) Mix 0.8 wt% of the final product mass of solubilizer (PEG-40 hydrogenated castor oil) and 0.01 wt% of the final product mass of borneol, and then heat and stir (50℃, 100 rpm, 15 min) to obtain phase b;

[0282] (3) Add phase b to phase a, heat and stir (50℃, 100rpm, 60min) to obtain the wet wipe compound solution.

[0283] Comparative Example 15

[0284] A method for preparing a wet wipe compound solution includes the following steps:

[0285] (1) Mix water (excluding other substances), 0.8 wt% of preservative (phenoxyethanol) and 1 wt% of humectant (aloe vera juice) of the final product, and heat and stir (50℃, 100 rpm, 30 min) to obtain phase a;

[0286] (2) Mix 0.8 wt% of the final product mass of solubilizer (PEG-40 hydrogenated castor oil) and 0.01 wt% of the final product mass of butanediol dioctanoic acid / didecanoic acid ester, and then heat and stir (50℃, 100 rpm, 15 min) to obtain phase b;

[0287] (3) Add phase b to phase a, heat and stir (50℃, 100rpm, 60min) to obtain the wet wipe compound solution.

[0288] Comparative Example 16

[0289] A method for preparing a wet wipe compound solution includes the following steps:

[0290] (1) Mix water (excluding other substances), 0.8 wt% of preservative (phenoxyethanol) and 1 wt% of humectant (aloe vera juice) of the final product, and heat and stir (50℃, 100 rpm, 30 min) to obtain phase a;

[0291] (2) Mix 0.8 wt% of the final product mass of solubilizer (PEG-40 hydrogenated castor oil), 0.001 wt% of the final product mass of butanediol dioctanoic acid / didecanoic acid ester and 0.001 wt% of the final product mass of hydroxypropyl-β-cyclodextrin, and then heat and stir (50℃, 100 rpm, 15 min) to obtain phase b;

[0292] (3) Add phase b to phase a, heat and stir (50℃, 100rpm, 60min) to obtain the wet wipe compound solution.

[0293] Comparative Example 17

[0294] A method for preparing a wet wipe compound solution includes the following steps:

[0295] (1) Water (excluding other substances) and 0.8 wt% of preservative (phenoxyethanol) were mixed and heated and stirred (50°C, 100 rpm, 30 min) to obtain phase a;

[0296] (2) Mix 0.8 wt% of the final product mass of solubilizer (PEG-40 hydrogenated castor oil) and 0.5 wt% of the final product mass of cooling agent composition (prepared in Example 1), and then heat and stir (50°C, 100 rpm, 15 min) to obtain phase b;

[0297] (3) Add phase b to phase a, heat and stir (50℃, 100rpm, 60min) to obtain the wet wipe compound solution.

[0298] Comparative Example 18

[0299] A method for preparing a wet wipe compound solution includes the following steps:

[0300] (1) Mix water (excluding other substances), 0.8 wt% of preservative (phenoxyethanol) and 1 wt% of humectant (aloe vera juice) of the final product, and heat and stir (50℃, 100 rpm, 30 min) to obtain phase a;

[0301] (2) Heat and stir 0.5 wt% of the cooling agent composition (prepared in Example 1) at 50°C, 100 rpm, for 15 min to obtain phase b;

[0302] (3) Add phase b to phase a, heat and stir (50℃, 100rpm, 60min) to obtain the wet wipe compound solution.

[0303] See the schematic diagram of the product obtained. Figure 17 As can be seen from the figure, the compound solution of Example 14 is transparent, while that of Comparative Example 18 is cloudy. This demonstrates the significant role of the PEG40 hydrogenated castor oil solubilizer in the product system.

[0304] Test Example 1: Cooling sensation test of percutaneous current sensory threshold (PCT) of cooling agent composition

[0305] Volunteers meeting the eligibility criteria were selected to participate in the test, which was conducted on the inner forearms of both arms. After applying the test sample, stimulation was performed with or without water, and measurements were taken at corresponding time points using a sensory nerve quantitative instrument via electrical stimulation. At 5 Hz, unmyelinated C fibers were primarily excited, mainly targeting pain, slow pain, temperature sensation, and postganglionic sympathetic nerves; at 250 Hz, A fibers were primarily excited, mainly targeting mechanoreceptors such as pressure, temperature, and fast pain; and at 2000 Hz, A fibers were primarily excited, mainly targeting skin touch and pressure sensation. Therefore, this test was designed to measure changes in human temperature sensation after using different amounts of sample at 5 Hz, with a higher signal indicating a lower perceived temperature.

[0306] Test area: the inner side of the forearms of both arms.

[0307] Sample application method: During the testing period, staff will apply the test sample to the corresponding test area according to the random table.

[0308] Test process:

[0309] ① Volunteer screening: Registration of enrollment information and informed consent

[0310] ② Apply the sample.

[0311] ③ Sensory nerve quantitative detection instrument electrical stimulation measurement method: After applying the sample, apply the coupling agent and detect the minimum electrical stimulation intensity change value at the corresponding time point.

[0312] Test period: 1 day.

[0313] Test time points: before applying the sample, 0 min, 5 min, 10 min, 20 min, 30 min, 60 min, 90 min, and 120 min after applying the sample.

[0314] Test samples: Example 1, Comparative Example 1, Comparative Example 2, Comparative Example 3, Comparative Example 4, Comparative Example 5, Comparative Example 7.

[0315] The test sample was prepared as a 0.5% aqueous solution for testing, while the control group was treated with water. The test results are shown in the figure. Figures 2-8 As shown.

[0316] Skin nerve sensitivity can be assessed using a current perception threshold (CPT) device. The CPT value in the sensitive skin group was significantly lower than that in the non-sensitive group, objectively reflecting changes in nerve sensitivity. The increase in CPT value after the application of the cooling substance indicates a reduction in skin nerve sensitivity, confirming its cooling effect. The onset time and duration of action of different cooling substances were studied using CPT. The test results show that the peak and duration of cooling sensation in Example 1 are superior to those in the comparative examples. The cooling sensation duration in Comparative Examples 1, 2, 3, and 7 is poor; the nerve potential sensitivity at 30 minutes is significantly lower than the peak value, indicating poor sustained cooling performance. The peak cooling sensation in Comparative Examples 4 and 5 is lower, and their cooling intensity is not as good as that in Example 1.

[0317] Test Example 2: Secondary Cooling Sensing Assessment of the Percutaneous Transcutaneous Current Threshold (PCT) of Cooling Agent Compositions

[0318] Test area: the inner side of the forearms of both arms.

[0319] Sample application method: During the testing period, staff will apply the test sample to the corresponding test area according to the random table.

[0320] Test process:

[0321] 1) Volunteer screening: Registration of enrollment information and informed consent

[0322] 2) Apply the sample.

[0323] 3) Sensory nerve quantitative detection instrument electrical stimulation measurement method: After applying the sample, apply the coupling agent and detect the minimum electrical stimulation intensity change value at the corresponding time point.

[0324] 4) For the secondary cooling stimulation test upon contact with water, non-woven fabric was applied for 5 seconds at the test time point. After the water evaporated, coupling agent was applied and the change value of minimum electrical stimulation intensity was measured.

[0325] Test period: 1 day.

[0326] Test time points: before applying the sample, 0 min, 15 min, 30 min, 60 min after applying the sample, immediately after contact with water, 15 min after contact with water, 30 min after contact with water, and 60 min after contact with water.

[0327] Test samples: Example 1, Comparative Example 1, Comparative Example 2, Comparative Example 7, Comparative Example 8.

[0328] The test sample was prepared as a 0.5% aqueous solution for testing, while the control group was treated with water. The test results are shown in the figure. Figures 9-13 As shown.

[0329] The test results show that the duration of both the primary and secondary cooling sensations in Example 1 is superior to that in the comparative examples. The duration of the secondary cooling sensation in Comparative Examples 1, 2, 7, and 8 is shorter. Because the preparation process in the comparative examples cannot form a good multiple encapsulation system, their encapsulation of cooling ingredients and long-lasting sustained-release performance are poor. Furthermore, due to the poor ability to encapsulate the cooling agent, the comparative examples exhibit a high peak instantaneous cooling intensity upon first skin contact, which can irritate the skin.

[0330] Test Example 3: Transmission Electron Microscopy (TEM) Observation of Cooling Agent Composition

[0331] The samples prepared in Example 1, Comparative Example 2, and Comparative Example 8 were subjected to TEM detection.

[0332] Weigh out the test sample and drop it onto a copper mesh. After a few seconds, gently remove the copper mesh sample with tweezers. Use filter paper to absorb excess liquid along one side, place the membrane side up on the filter paper to dry, and observe and photograph it using a transmission electron microscope. The results are as follows: Figures 14-16 As shown.

[0333] As shown in the figure, the product prepared in Example 1 can uniformly disperse the particles encapsulating the cooling agent components in the system, forming a stable multi-encapsulation system, while the products prepared in Comparative Examples 2 and 8 have poor ability to encapsulate the cooling agent.

[0334] Test Example 4: Long-lasting cooling sensation test of the percutaneous current sensory threshold (PCT) of the wet wipe compound solution

[0335] Volunteers meeting the eligibility criteria were selected to participate in the test, which was conducted on the inner forearms of both arms. After applying the test sample, stimulation was performed with or without water, and measurements were taken at corresponding time points using a sensory nerve quantitative instrument via electrical stimulation. At 5 Hz, unmyelinated C fibers were primarily excited, mainly targeting pain, slow pain, temperature sensation, and postganglionic sympathetic nerves; at 250 Hz, A fibers were primarily excited, mainly targeting mechanoreceptors such as pressure, temperature, and fast pain; and at 2000 Hz, A fibers were primarily excited, mainly targeting skin touch and pressure sensation. Therefore, this test was designed to measure changes in human temperature sensation after using different amounts of sample at 5 Hz, with a higher signal indicating a lower perceived temperature.

[0336] Test area: the inner side of the forearms of both arms.

[0337] Sample application method: During the testing period, staff will apply the test sample to the corresponding test area according to the random table.

[0338] Test process:

[0339] ① Volunteer screening: Registration of enrollment information and informed consent

[0340] ② Apply the sample.

[0341] ③ Sensory nerve quantitative detection instrument electrical stimulation measurement method: After applying the sample, apply the coupling agent and detect the minimum electrical stimulation intensity change value at the corresponding time point.

[0342] Test time points:

[0343] Before applying the sample, and 0 min, 5 min, 10 min, 20 min, 30 min, 60 min, 90 min, and 120 min after applying the sample.

[0344] Test samples: Example 14, Comparative Example 9, Comparative Example 10, Comparative Example 11, Comparative Example 14, Comparative Example 15.

[0345] The control group consisted of water.

[0346] Test results are as follows Figures 18-23 As shown in the results, within 120 minutes, the intensity and duration of the cooling sensation in the comparative example were both lower than those in Example 1. Example 14 exhibited superior immediate and 90-minute cooling sensations compared to the comparative example. Comparative Examples 14 and 15 were essentially unable to maintain an effective cooling sensation.

[0347] Test Example 5: Secondary Cooling Sensation Assessment of the Percutaneous Transdermal Threshold (PCT) of the Wet Wipe Compound Solution

[0348] Test area: the inner side of the forearms of both arms.

[0349] Sample application method: During the testing period, staff will apply the test sample to the corresponding test area according to the random table.

[0350] Test process:

[0351] 1) Volunteer screening: Registration of enrollment information and informed consent

[0352] 2) Apply the sample.

[0353] 3) Sensory nerve quantitative detection instrument electrical stimulation measurement method: After applying the sample, apply the coupling agent and detect the minimum electrical stimulation intensity change value at the corresponding time point.

[0354] 4) For the secondary cooling stimulation test upon contact with water, non-woven fabric was applied for 5 seconds at the test time point. After the water evaporated, coupling agent was applied and the change value of minimum electrical stimulation intensity was measured.

[0355] Test time points:

[0356] Before applying the sample, 0 min, 15 min, 30 min, 60 min after applying the sample, immediately after contact with water, 15 min after contact with water, 30 min after contact with water, and 60 min after contact with water.

[0357] Test samples: Example 14, Comparative Example 12, Comparative Example 13.

[0358] The control group consisted of water.

[0359] Test results are available Figures 24-26 As shown in the figure. The test results show that the comparative example does not have a second cooling effect. Example 14, after a second contact with water, simulates the sweating process of the human body after use, and has the performance of releasing a second cooling sensation, and the degree of the second cooling sensation is higher than the first immediate cooling sensation.

[0360] Test Example 6: Sensory Evaluation of Wet Wipe Compound Solution

[0361] This method aims to quantitatively assess the subjective skin irritation (such as stinging, burning sensation) and degree of skin cooling sensation when test samples are used on healthy human skin by a trained sensory evaluation team.

[0362] Testing area: The inner forearm is usually chosen, as the skin in this area is more sensitive and less affected by external factors. If testing facial products, it can be done on the outer cheek, but stricter environmental control and longer intervals are required.

[0363] Test process:

[0364] 1) Upon entering the laboratory, the subject sits and rests for 15 minutes to acclimatize. The operator marks a uniformly sized test area (e.g., 3cm x 3cm) on the inside of the subject's forearm.

[0365] 2) Sample application: A trained operator takes a fixed amount (0.02 g / cm²) of sample using a quantitative syringe or by weighing and applies it evenly to the marked area using a standardized technique (such as circular motion).

[0366] 3) Immediate and Continuous Scoring: After sample application, subjects scored each dimension at the following time points:

[0367] Immediate sensation assessment: 0 minutes (immediately after application), 1 minute, 2 minutes, 5 minutes

[0368] Endurance assessment: 15 minutes, 30 minutes, 60 minutes, 90 minutes

[0369] 4) Test samples: Example 14, Comparative Example 12, Comparative Example 13, Comparative Example 17

[0370] 5) Rating Dimensions and Data Collection

[0371] A. Irritating

[0372] Definition: Unpleasant sensations caused by product use, such as stinging, burning, itching, tightness, or numbness.

[0373] Rating scale (0-10 points):

[0374] 0 points: Absolutely no stimulation whatsoever.

[0375] 2 points: Slight irritation, noticeable but negligible.

[0376] 5 points: Moderate intensity of stimulation, noticeable but not bothersome.

[0377] 8 points: Intense stimulation, disturbing.

[0378] 10 / 10: The stimulation is extremely intense and unbearable.

[0379] Data recording: Record the stimulus score at each time point.

[0380] B. Cooling sensation

[0381] Definition: The pleasant feeling of coolness and refreshment experienced after using the product.

[0382] Rating scale (0-10 points):

[0383] 0 points: Absolutely no cooling sensation.

[0384] 2 points: Slight cooling sensation, perceptible.

[0385] 5 points: Moderate cooling sensation, feels refreshing.

[0386] 8 points: Strong cooling sensation, feels very refreshing.

[0387] 10 / 10: An extremely strong cooling and numbing sensation.

[0388] Data recording: Record the cooling sensation score at each time point.

[0389] The test results are attached. Figures 27-28 According to the test results, Example 14 showed a shorter duration of cooling sensation compared to the comparative example. The cooling sensation in a single-component cooling agent is related to the properties of the substance and has a shorter duration. Furthermore, the single-component cooling agent, while providing a cooling sensation, also causes some irritation and a cold, painful feeling, making it less convenient to use. Comparative Example 17 showed that the cooling ingredients can irritate the skin when they are working; therefore, the addition of a moisturizer can reduce the discomfort caused by the cooling sensation.

[0390] Test Example 7: Transmission Electron Microscopy (TEM) Observation of Wet Wipe Compound Solution

[0391] The samples prepared in Example 14, Comparative Example 10, and Comparative Example 16 were subjected to TEM detection.

[0392] Weigh out the test sample and drop it onto the copper mesh. After a few seconds, gently pick up the copper mesh sample with tweezers, use filter paper to absorb the excess liquid along one side, place the membrane face up on the filter paper to dry, and observe and photograph it with a transmission electron microscope.

[0393] The results are attached. Figure 29 As shown in the results, Example 14 exhibits a clearly structured multi-encapsulated composite system, while Comparative Example 10 only shows irregular crystal precipitation with no encapsulated carrier structure. Comparative Example 16 shows only irregular aggregates of hydroxypropyl cellulose in aqueous solution.

[0394] The applicant declares that the present invention is illustrated by the above embodiments, but the present invention is not limited to the above embodiments, that is, it does not mean that the present invention must rely on the above embodiments to be implemented. Those skilled in the art should understand that any improvements to the present invention, equivalent substitutions of individual raw materials in the product of the present invention, addition of auxiliary components, selection of specific methods, etc., all fall within the protection scope and disclosure scope of the present invention.

Claims

1. A wet wipe compound solution with long-lasting cooling and secondary cooling effects, characterized in that, It is prepared from the following raw materials in parts by weight: 80-96 parts solvent, 0.1-2 parts cooling agent composition, 1-10 parts humectant, 0.1-2 parts solubilizer, and 0.1-5 parts preservative; The cooling agent composition, in terms of its total mass fraction of 100%, is prepared from the following raw materials: 76-95.29% 1,3-propanediol, 2-9% methyl diisopropyl propionamide, 2-8.5% menthol alkyl ethylamine, 0.5-3.5% hydroxypropyl cellulose, 0.1-2% hydroxypropyl-β-cyclodextrin, 0.1-2% borneol, and 0.01-1% oils; The oil is selected from one or more of butylene glycol dioctanoic acid / didecanoate, isononyl isononanoate, and lemon eucalyptus oil; The preparation of the cooling agent composition includes the following steps: S1. Hydroxypropyl cellulose, hydroxypropyl-β-cyclodextrin, and 1,3-propanediol (part 1) are mixed in the specified proportions and then homogenized to obtain phase A. S2. Dissolve borneol and oil in the second part of 1,3-propanediol, stir and process to obtain phase B; S3. Add phase A obtained in step S1 to phase B obtained in step S2, stir and then homogenize to obtain phase C. S4. Add methyl diisopropyl propionamide to phase C obtained in step S3, stir and then homogenize to obtain phase D; S5. Menthaneformyl ethylamine is added to phase D, heated and stirred, and then homogenized. After the homogenization is completed, the mixture is cooled and filtered to obtain the cooling agent composition. In step S1, the temperature for stirring and mixing is 10~35℃; In step S4, the stirring temperature is 75~90℃; In step S5, the heating and stirring temperature is 75~90℃.

2. The wet wipe compound liquid with long-lasting cooling and secondary cooling sensation according to claim 1, characterized in that, It is prepared from the following raw materials in parts by weight: 90 parts solvent, 0.5 parts cooling agent composition, 1 part humectant, 0.8 parts solubilizer, and 0.8 parts preservative.

3. The wet wipe compound liquid with long-lasting cooling and secondary cooling sensation according to claim 1, characterized in that, The solvent is water; The moisturizer is selected from one or both of aloe vera juice and glycerin; The solubilizer is selected from one or more of PEG-40 hydrogenated castor oil, polyvinylpyrrolidone, and polysorbate-20; The preservative is selected from one or both of octanoyl hydroxamic acid and phenoxyethanol.

4. The wet wipe compound liquid with long-lasting cooling and secondary cooling sensation according to claim 1, characterized in that, In step S1, the rotation speed is 50~500 rpm and the processing time is 60~120 min; the homogenization speed is 1000~10000 rpm and the processing time is 5~30 min. The mass ratio of the sum of the masses of hydroxypropyl cellulose and hydroxypropyl-β-cyclodextrin to the mass of 1,3-propanediol in the first part is 1:(10~20). In step S2, the stirring temperature is 40~65℃, the stirring speed is 10~60rpm, and the processing time is 10~60min; In step S3, the stirring temperature is 40~60℃ and the processing time is 30~120min; the homogenization speed is 1000~10000rpm and the processing time is 5~30min. In step S4, the rotation speed is 50~500 rpm and the processing time is 30~120 min; the homogenization speed is 1000~10000 rpm and the processing time is 5~30 min. In step S5, the rotation speed is 50~500 rpm and the processing time is 30~120 min; the homogenization speed is 1000~10000 rpm and the processing time is 5~30 min; the temperature is reduced to 20~40℃; and the filtration mesh size is 150~250 mesh.

5. A method for preparing the wet wipe compound solution according to any one of claims 1 to 4, characterized in that, Includes the following steps: (1) After mixing water, preservative and humectant, heat and stir to obtain phase a; (2) After mixing the solubilizer and cooling agent composition, heat and stir to obtain phase b; (3) Add phase b to phase a, heat and stir to obtain wet wipe compound solution.

6. The preparation method according to claim 5, characterized in that, In step (1), the heating and stirring temperature is 45~60℃, the speed is 20~500rpm, and the stirring time is 30~60min; In step (2), the heating and stirring temperature is 50~70℃, the speed is 20~500rpm, and the stirring time is 10~60min; In step (3), the heating and stirring temperature is 40~65℃, the speed is 30~120rpm, and the stirring time is 30~120min.

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