Capsule preparation for supporting mood health and improving depression and hormone balance

Abstract

The invention discloses a capsule preparation for supporting mood health and improving depression and hormone balance, and relates to the technical field of health food. The capsule preparation comprises the following active components and auxiliary materials in parts by weight: the active components: 3-6 parts of a Malaysia flaxseed extract (containing 12% of lignan), 2-5 parts of Singago pumpkin seed concentrated powder (containing 4mg / g of zinc), 1-3 parts of Indonesia sesame essence (containing lignan), 2-4 parts of a sunflower seed extract (containing vitamin E), 1-3 parts of an olive leaf extract (containing 0.5% of an olive split iridoid compound) and an angelica sinensis extract (containing 0.5% of an olive split iridoid compound). 2-5 parts of Hypericum perforatum (flavonoid gt; 2.5%) 3-7 parts. Through scientific and reasonable formula design, various active components with synergistic effects are organically combined, the dual effects of emotion regulation and hormone balance can be achieved from multiple targets and multiple ways, the content of effective components is stable, bioavailability is high, taking is convenient, safety is high, and the actual requirements of consumers can be met.

Description

Technical Field

[0001] This invention relates to the technical field of health food products, and more particularly to a capsule formulation that supports emotional health and improves depression and hormonal balance. Background Technology

[0002] With the fast pace of modern life, increased work pressure, and changes in the living environment, anxiety, depression, and other emotional problems are increasingly becoming significant factors affecting people's physical and mental health. Low mood and anxiety not only lead to psychological problems such as sleep disorders, poor concentration, and communication difficulties, but also further trigger physiological problems such as endocrine imbalances and hormonal disturbances. Hormonal imbalances, in turn, exacerbate mood swings, creating a vicious cycle. Prolonged exposure to this state can lead to a series of health problems, including weakened immunity, deteriorating skin condition, and metabolic disorders, seriously impacting people's quality of life and work efficiency.

[0003] Currently, methods for regulating mood problems and hormonal balance mainly include drug therapy and health supplements. While drug therapy may achieve certain effects in the short term, it often has side effects such as drowsiness, dry mouth, and gastrointestinal discomfort, and long-term use may lead to dependence, which is detrimental to long-term health. Existing health supplements mostly suffer from a single target, either focusing solely on mood regulation or only targeting hormonal balance, making it difficult to achieve synergistic improvement in both emotional health and hormonal balance. Furthermore, some products have drawbacks such as unstable active ingredient content, poor absorption, and inconvenient administration, failing to meet consumers' actual needs.

[0004] For example, many existing mood-regulating compositions use a single herbal extract as their core ingredient. While they can alleviate anxiety to some extent, they lack the ability to regulate hormone levels. This can lead to situations where users experience mood improvement but other symptoms caused by hormonal imbalances remain unresolved. Hormone-regulating products, on the other hand, often ignore the impact of emotions on hormones and fail to address the root cause of the problem. Furthermore, some products are available in powder or liquid form. Powder forms have a poor taste, while liquid forms are inconvenient to carry and have a short shelf life.

[0005] Therefore, developing a capsule formulation that can simultaneously support emotional health, improve depressive states, and regulate hormonal balance, with stable active ingredients, good absorption, convenient administration, and high safety, has significant practical implications and market value. Summary of the Invention

[0006] To address the aforementioned problems in existing technologies, this invention provides a capsule formulation that supports emotional health, improves depression, and balances hormones, along with its preparation method and applications. This capsule formulation, through a scientifically designed formula, organically combines multiple synergistic active ingredients, achieving dual effects of mood regulation and hormone balance through multiple targets and pathways. Furthermore, it features stable active ingredient content, high bioavailability, convenient administration, and high safety, thus meeting the actual needs of consumers.

[0007] To solve the above-mentioned technical problems, the present invention provides the following technical solution:

[0008] A capsule formulation that supports emotional health and improves depression and hormonal balance comprises the following active ingredients and excipients in parts by weight:

[0009] Active ingredients: Malaysian flaxseed extract (containing 12% lignans) 3-6 parts, Singapore pumpkin seed concentrate powder (zinc 4mg / g) 2-5 parts, Indonesian sesame extract (containing lignans) 1-3 parts, sunflower seed extract (containing vitamin E) 2-4 parts, olive leaf extract (olive schizocarpine ethers 0.5%) 1-3 parts, angelica extract (Singapore processing method) 2-5 parts, St. John's wort (flavonoids >2.5%) 3-7 parts. Chasteberry extract (flavonoids 2.5%) 2-5 parts, Ashwagandha extract (ashola lactone 10%) 3-6 parts, 5-hydroxytryptophan (purity >98%) 0.5-1.5 parts, Ziziphus jujuba seed extract (total saponins 2%) 2-5 parts, L-theanine 1-3 parts, γ-aminobutyric acid (90%) 1-4 parts, 5-aminolevulinic acid (5-ALA) 0.5-2 parts, Albizia julibrissin bark extract 2-5 parts, Zembulin 0.3-1 part;

[0010] Excipients: 5-10 parts starch, 0.1-0.5 parts magnesium stearate;

[0011] The capsule formulation is a hard capsule, each weighing 0.45g, and the content of the active ingredient in each capsule is 0.38-0.42g.

[0012] As a preferred embodiment of the capsule formulation for supporting emotional health and improving depression and hormonal balance described in this invention, the active ingredients are expressed in the following weight proportions: 4-5 parts Malaysian flaxseed extract (containing 12% lignans), 3-4 parts Singapore pumpkin seed concentrate (zinc 4 mg / g), 2 parts Indonesian sesame extract (containing lignans), 3 parts sunflower seed extract (containing vitamin E), 2 parts olive leaf extract (containing 0.5% oligocyclic ether terpenes), and 3-5 parts Angelica sinensis extract (processed using Singaporean methods). 4 parts, St. John's wort (flavonoids >2.5%) 4-6 parts, Chasteberry extract (flavonoids 2.5%) 3-4 parts, Ashwagandha extract (asholinone 10%) 4-5 parts, 5-hydroxytryptophan (purity >98%) 0.8-1.2 parts, Ziziphus jujuba seed extract (total saponins 2%) 3-4 parts, L-theanine 2 parts, γ-aminobutyric acid (90%) 2-3 parts, 5-aminolevulinic acid (5-ALA) 1-1.5 parts, Albizia julibrissin bark extract 3-4 parts, Zembulin 0.5-0.8 parts.

[0013] As a preferred embodiment of the capsule formulation for supporting emotional health and improving depression and hormonal balance described in this invention, the active ingredients are expressed in the following weight proportions: 4.5 parts Malaysian flaxseed extract (containing 12% lignans), 3.5 parts Singapore pumpkin seed concentrate (zinc 4 mg / g), 2 parts Indonesian sesame extract (containing lignans), 3 parts sunflower seed extract (containing vitamin E), 2 parts olive leaf extract (containing 0.5% oligocyclic ether terpenes), and 3.5 parts Angelica sinensis extract (processed using Singaporean methods). 5 parts of St. John's wort (flavonoids >2.5%), 3.5 parts of Chaenomeles speciosa extract (flavonoids 2.5%), 4.5 parts of Ashwagandha extract (asholinone 10%), 1 part of 5-hydroxytryptophan (purity >98%), 3.5 parts of Ziziphus jujuba seed extract (total saponins 2%), 2 parts of L-theanine, 2.5 parts of γ-aminobutyric acid (90%), 1.2 parts of 5-aminolevulinic acid (5-ALA), 3.5 parts of Albizia julibrissin bark extract, and 0.6 parts of zemblin; excipients: 7 parts of starch and 0.3 parts of magnesium stearate.

[0014] As a preferred embodiment of the capsule formulation for supporting emotional health and improving depression and hormonal balance described in this invention, the Malaysian flaxseed extract is prepared by the following method: Malaysian flaxseeds are taken, impurities are removed, and the extract is pulverized to 40-60 mesh. 8-12 times the weight of 70%-80% ethanol solution is added, and the extract is refluxed at 50-60°C for 2-3 times, 1.5-2 hours each time. The extracts are combined and concentrated under reduced pressure until there is no alcohol odor to obtain an extract. The extract is vacuum dried and pulverized to 80-100 mesh to obtain the final product. The lignan content is determined to be 12% by high performance liquid chromatography.

[0015] As a preferred embodiment of the capsule formulation for supporting emotional health and improving depression and hormonal balance described in this invention, the preparation method of the Singapore pumpkin seed concentrate powder is as follows: Singapore pumpkin seeds are taken, shelled, and pulverized to 50-70 mesh. 6-10 times their weight of deionized water are added, and the mixture is ultrasonically extracted 1-2 times at 45-55℃ for 40-60 minutes each time, with an ultrasonic power of 300-400W. The extracts are combined, centrifuged, and the supernatant is collected. The supernatant is then spray-dried at an inlet air temperature of 180-200℃ and an outlet air temperature of 80-90℃ to obtain the concentrate powder. The zinc content is determined to be 4 mg / g by atomic absorption spectrophotometry.

[0016] As a preferred embodiment of the capsule formulation for supporting emotional health and improving depression and hormonal balance described in this invention, the Angelica sinensis extract is prepared using a Singapore processing technique. The specific steps are as follows: Angelica sinensis slices are taken, mixed with rice wine (10%–15% of the weight of the Angelica sinensis slices), and left to soak until the rice wine is absorbed. The mixture is then placed in a steaming device and steamed at 105–110°C for 20–30 minutes. After drying, the mixture is pulverized to 50–60 mesh. 7–9 times its weight of 60%–70% ethanol solution is added, and the mixture is refluxed twice for 1–1.5 hours each time. The extracts are combined, concentrated, and dried to obtain the final product.

[0017] As a preferred embodiment of the capsule formulation for supporting emotional health and improving depression and hormonal balance described in this invention, the preparation method of the jujube seed extract is as follows: take jujube seeds, pulverize them to 40-50 mesh, add 10-14 times their weight of deionized water, soak for 2-3 hours, then decoct at 90-100℃ 2-3 times, each time for 1-1.5 hours, combine the decoctions, filter, concentrate the filtrate under reduced pressure to an extract with a relative density of 1.2-1.3 (60℃), vacuum dry, and pulverize to 80 mesh to obtain the extract. The total saponin content is determined to be 2% by ultraviolet spectrophotometry.

[0018] As a preferred embodiment of the capsule formulation for supporting emotional health and improving depression and hormonal balance according to the present invention, the method for preparing the capsule formulation is characterized by comprising the following steps:

[0019] (1) Raw material pretreatment: Each active component and excipient is passed through an 80-100 mesh sieve to remove impurities and is ready for use;

[0020] (2) Mixing: First, mix starch and part of the active components evenly in equal increments, then add the remaining active components and stir for 15-20 minutes. After mixing evenly, add magnesium stearate and continue mixing for 3-5 minutes to obtain the capsule contents.

[0021] (3) Filling: The contents of the capsules obtained in step (2) are filled into hollow hard capsules using a fully automatic capsule filling machine. The filling amount is adjusted so that the weight of each capsule is 0.45g to obtain the initial product.

[0022] (4) Polishing: Place the initial product obtained in step (3) into a capsule polishing machine and polish for 2-3 minutes to remove surface dust;

[0023] (5) Quality inspection: The polished capsules are tested for weight difference, disintegration time and microbial limit. Those that meet the standards are finished products.

[0024] (6) Packaging: Pack the qualified finished products in batches of 2 capsules / bag, then pack them into boxes of 28 bags per box.

[0025] As a preferred embodiment of the capsule formulation for supporting emotional health and improving depression and hormone balance described in this invention, the relative humidity of the mixing environment in step (2) is 45% to 60%, and the temperature is 18 to 25°C; the weight difference limit in step (5) is ±7.5%, and the disintegration time is ≤30 min.

[0026] As a preferred embodiment of the capsule formulation for supporting emotional health, improving depression and hormonal balance described in this invention, the capsule formulation is used in the preparation of health foods that support emotional health, improve depressive states, or regulate hormonal balance.

[0027] The beneficial effects of this invention are as follows: The formula is scientifically sound and exhibits significant synergistic effects. Through the screening and optimization of the proportions of various active ingredients, this invention achieves a synergistic improvement in mood regulation and hormonal balance. Each active ingredient works from different targets. For example, St. John's wort and 5-hydroxytryptophan directly regulate neurotransmitter levels to improve mood; Malaysian flaxseed extract and chasteberry extract regulate hormone levels; and Ashwagandha extract and γ-aminobutyric acid relieve stress and regulate the endocrine axis. The multiple ingredients work together to form a complete system of action, solving the problem of single-function products in existing products.

[0028] The active ingredients are clearly defined and their content is stable: This invention strictly limits the content of the active ingredients in each active component, such as 12% lignans in Malaysian flaxseed extract and 4 mg / g zinc in Singapore pumpkin seed concentrate. At the same time, by optimizing the preparation methods of each component, the extraction rate and stability of the active ingredients are ensured, thereby guaranteeing the reliability and consistency of the product efficacy.

[0029] High bioavailability and good absorption: This invention uses a capsule dosage form. The capsule shell can protect the contents from premature destruction by gastric acid in the gastrointestinal tract, allowing the active ingredients to reach the intestines before being released, thus improving the bioavailability of the active ingredients. At the same time, the particle size of each active component is small after being pulverized, which is conducive to intestinal absorption.

[0030] Convenient to take and highly safe: Each capsule of the present invention weighs 0.45g, and the recommended dosage is 2 capsules once a day. It is convenient to take and easy to adhere to the regimen. The product uses natural active ingredients and has undergone rigorous safety evaluation and verification. It has no obvious side effects and is suitable for long-term use.

[0031] The preparation process is simple and controllable, and suitable for industrial production: The preparation method of this invention adopts conventional health food production equipment and processes. The steps are simple and easy to operate. Moreover, each process parameter is clear and easy to control, which can ensure the stability of product quality and is suitable for large-scale industrial production. Attached Figure Description

[0032] Figure 1 This is a schematic diagram of the basic process of a capsule formulation that supports emotional health and improves depression and hormonal balance, as provided in one embodiment of the present invention. Detailed Implementation

[0033] To make the above-mentioned objects, features and advantages of the present invention more apparent and understandable, the specific embodiments of the present invention will be described in detail below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments.

[0034] Example 1

[0035] A capsule formulation supporting emotional health and improving depression and hormonal balance, comprising the following components by weight: 3 parts Malaysian flaxseed extract (containing 12% lignans), 2 parts Singapore pumpkin seed concentrate (zinc 4mg / g), 1 part Indonesian sesame extract (containing lignans), 2 parts sunflower seed extract (containing vitamin E), 1 part olive leaf extract (containing 0.5% oligocyclic ethers), 2 parts angelica extract (processed using Singaporean methods), and 1 part St. John's wort (flavonoids). 3 parts of flavonoids (>2.5%), 2 parts of chasteberry extract (flavonoids 2.5%), 3 parts of ashwagandha extract (ashwagandrolone 10%), 0.5 parts of 5-hydroxytryptophan (purity >98%), 2 parts of jujube seed extract (total saponins 2%), 1 part of L-theanine, 1 part of γ-aminobutyric acid (90%), 0.5 parts of 5-aminolevulinic acid (5-ALA), 2 parts of albizia bark extract, 0.3 parts of zemblin, 5 parts of starch, and 0.1 parts of magnesium stearate.

[0036] Preparation method:

[0037] (1) Raw material pretreatment: Each active component and excipient is passed through an 80-mesh sieve to remove impurities and is ready for use;

[0038] (2) Mixing: Under an environment of 45% relative humidity and 18°C, starch, Malaysian flaxseed extract and Singapore pumpkin seed concentrate were mixed evenly in equal increments. Then the remaining active ingredients were added and stirred for 15 minutes. After mixing evenly, magnesium stearate was added and mixed for another 3 minutes to obtain the capsule contents.

[0039] (3) Filling: The contents of the capsules are filled into the hollow hard capsules using a fully automatic capsule filling machine. The filling amount is adjusted so that the weight of each capsule is 0.45g to obtain the initial product;

[0040] (4) Polishing: Place the initial product into a capsule polishing machine and polish for 2 minutes to remove surface dust;

[0041] (5) Quality inspection: The polished capsules are tested for weight difference, disintegration time and microbial limit. The weight difference limit is ±7.5%, the disintegration time is ≤30min, and the microbial limit meets GB16740-2014 "General Hygiene Requirements for Health Food". Those that meet the standards are finished products.

[0042] (6) Packaging: Pack the qualified finished products in 2-pill bags, and then put them into a box with 28 bags per box.

[0043] Example 2

[0044] A capsule formulation supporting emotional health and improving depression and hormonal balance, comprising the following components by weight: 6 parts Malaysian flaxseed extract (containing 12% lignans), 5 parts Singapore pumpkin seed concentrate (zinc 4 mg / g), 3 parts Indonesian sesame extract (containing lignans), 4 parts sunflower seed extract (containing vitamin E), 3 parts olive leaf extract (containing 0.5% oligosaccharide ethers), 5 parts angelica extract (processed using Singaporean methods), and 1 part St. John's wort (…). Flavonoids >2.5% 7 parts, Chasteberry extract (flavonoids 2.5%) 5 parts, Ashwagandha extract (ashine lactone 10%) 6 parts, 5-hydroxytryptophan (purity >98%) 1.5 parts, Ziziphus jujuba seed extract (total saponins 2%) 5 parts, L-theanine 3 parts, γ-aminobutyric acid (90%) 4 parts, 5-aminolevulinic acid (5-ALA) 2 parts, Albizia julibrissin bark extract 5 parts, Zemblin 1 part, starch 10 parts, magnesium stearate 0.5 parts.

[0045] Preparation method:

[0046] (1) Raw material pretreatment: Each active component and excipient is passed through a 100-mesh sieve to remove impurities and is ready for use;

[0047] (2) Mixing: Under an environment of 60% relative humidity and 25℃, starch, St. John's wort and Chasteberry extract were mixed evenly in equal increments, and then the remaining active ingredients were added. The mixture was stirred for 20 minutes and then magnesium stearate was added after it was mixed evenly. The mixture was then stirred for 5 minutes to obtain the capsule contents.

[0048] (3) Filling: The contents of the capsules are filled into the hollow hard capsules using a fully automatic capsule filling machine. The filling amount is adjusted so that the weight of each capsule is 0.45g to obtain the initial product;

[0049] (4) Polishing: Place the initial product into a capsule polishing machine and polish for 3 minutes to remove surface dust;

[0050] (5) Quality inspection: The polished capsules are tested for weight difference, disintegration time and microbial limit. The weight difference limit is ±7.5%, the disintegration time is ≤30min, and the microbial limit meets GB16740-2014 "General Hygiene Requirements for Health Food". Those that meet the standards are finished products.

[0051] (6) Packaging: Pack the qualified finished products in 2-pill bags, and then put them into a box with 28 bags per box.

[0052] Example 3

[0053] A capsule formulation supporting emotional health and improving depression and hormonal balance, comprising the following components by weight: 4.5 parts Malaysian flaxseed extract (containing 12% lignans), 3.5 parts Singapore pumpkin seed concentrate (zinc 4 mg / g), 2 parts Indonesian sesame extract (containing lignans), 3 parts sunflower seed extract (containing vitamin E), 2 parts olive leaf extract (containing 0.5% oligocyclic ethers), 3.5 parts angelica extract (processed using Singaporean methods), and 1 part St. John's wort (flavonoids). >2.5%) 5 parts, Chasteberry extract (flavonoids 2.5%) 3.5 parts, Ashwagandha extract (ashine lactone 10%) 4.5 parts, 5-hydroxytryptophan (purity >98%) 1 part, Ziziphus jujuba seed extract (total saponins 2%) 3.5 parts, L-theanine 2 parts, γ-aminobutyric acid (90%) 2.5 parts, 5-aminolevulinic acid (5-ALA) 1.2 parts, Albizia julibrissin bark extract 3.5 parts, Zeemulin 0.6 parts, starch 7 parts, magnesium stearate 0.3 parts.

[0054] Preparation method:

[0055] (1) Raw material pretreatment: Each active component and excipient is passed through a 90-mesh sieve to remove impurities and set aside; Malaysian flaxseed extract is prepared by the following method: Malaysian flaxseed is taken, impurities are removed and it is pulverized to 50 mesh, 10 times its weight of 75% ethanol solution is added, and it is refluxed at 55℃ twice, 1.8h each time. The extracts are combined and concentrated under reduced pressure until there is no alcohol odor to obtain the extract. The extract is vacuum dried and pulverized to 90 mesh to obtain the extract; The preparation method of Singapore pumpkin seed concentrate is as follows: Singapore pumpkin seeds are taken, shelled and pulverized to 60 mesh, 8 times its weight of deionized water is added, and it is ultrasonically extracted at 50℃ 1.5 times, 50min each time, with an ultrasonic power of 350W. The extracts are combined, the supernatant is centrifuged and spray-dried. The inlet air temperature is 190℃ and the outlet air temperature is 85℃ to obtain concentrated powder; Angelica sinensis extract is prepared using Singapore processing technology: Angelica sinensis slices are taken, 12% rice wine is added and mixed well, and the mixture is left to soak until the rice wine is absorbed. It is then placed in a steaming device and steamed at 108℃ for 25 minutes. After drying, it is pulverized to 55 mesh, 8 times its weight of 65% ethanol solution is added, and the mixture is refluxed twice for 1.2 hours each time. The extracts are combined, concentrated, and dried to obtain the final product; The preparation method of Ziziphus jujuba seed extract is as follows: Ziziphus jujuba seeds are taken, pulverized to 45 mesh, 12 times its weight of deionized water is added, and the mixture is soaked for 2.5 hours. It is then decocted twice at 95℃ for 1.2 hours each time. The decoctions are combined, filtered, and the filtrate is concentrated under reduced pressure to an extract with a relative density of 1.25 (60℃). After vacuum drying, it is pulverized to 80 mesh to obtain the final product;

[0056] (2) Mixing: Under an environment of 50% relative humidity and 22℃, starch, 5-hydroxytryptophan and zembrine are mixed evenly in equal increments. Then the remaining active ingredients are added and stirred for 18 minutes. After mixing evenly, magnesium stearate is added and mixed for another 4 minutes to obtain the capsule contents.

[0057] (3) Filling: The contents of the capsules are filled into the hollow hard capsules using a fully automatic capsule filling machine. The filling amount is adjusted so that the weight of each capsule is 0.45g to obtain the initial product;

[0058] (4) Polishing: Place the initial product into a capsule polishing machine and polish for 2.5 minutes to remove surface dust;

[0059] (5) Quality inspection: The polished capsules are tested for weight difference, disintegration time and microbial limit. The weight difference limit is ±7.5%, the disintegration time is ≤30min, and the microbial limit meets GB16740-2014 "General Hygiene Requirements for Health Food". Those that meet the standards are finished products.

[0060] (6) Packaging: Pack the qualified finished products in 2-pill bags, and then put them into a box with 28 bags per box.

[0061] Effect verification experiment

[0062] To verify the efficacy of the capsule formulation of this invention, 60 volunteers with symptoms of low mood, anxiety, and mild hormonal imbalance (such as premenstrual syndrome in women and poor sleep quality in men) were randomly divided into an experimental group and a control group, with 30 volunteers in each group. The experimental group took the capsule formulation prepared in Example 3 of this invention, once daily, 2 capsules each time; the control group took placebo capsules without the active ingredient, with the same dosage and administration as the experimental group. After 4 weeks of continuous use, the emotional state and hormone levels of the two groups of volunteers were assessed.

[0063] Mood status was assessed using the Self-Rating Anxiety Scale (SAS) and the Self-Rating Depression Scale (SDS), and hormone levels were assessed by measuring serum levels of estrogen (female), testosterone (male), and cortisol.

[0064] The results showed that after 4 weeks of treatment, the SAS and SDS scores of volunteers in the experimental group decreased by 32.5% and 35.2% respectively compared to before treatment, while no significant changes were observed in the control group. Serum estrogen levels in female volunteers improved by 28.6% compared to before treatment, and serum testosterone levels in male volunteers improved by 25.3% compared to before treatment. Serum cortisol levels in both groups decreased by 29.8% compared to before treatment, while hormone levels in the control group showed no significant changes. Furthermore, no significant side effects were observed in the experimental group during treatment, indicating good safety.

[0065] The above experimental results show that the capsule formulation of the present invention has good effects in supporting emotional health, improving depressive state and regulating hormone balance, and has high safety, making it worthy of widespread application.

[0066] The formula is scientifically sound and exhibits significant synergistic effects: This invention achieves synergistic improvement in mood regulation and hormonal balance through the screening and optimization of multiple active ingredients. Each active ingredient works on different targets; for example, St. John's wort and 5-hydroxytryptophan directly regulate neurotransmitter levels to improve mood; Malaysian flaxseed extract and chasteberry extract regulate hormone levels; and Ashwagandha extract and γ-aminobutyric acid relieve stress and regulate the endocrine axis. The multiple ingredients work together to form a complete system of action, solving the problem of single-function products in existing products.

[0067] This invention strictly limits the content of active ingredients in each active component. For example, Malaysian flaxseed extract contains 12% lignans, and Singapore pumpkin seed concentrate contains 4 mg / g of zinc. Simultaneously, by optimizing the preparation methods of each component, the extraction rate and stability of the active ingredients are ensured, thereby guaranteeing the reliability and consistency of the product's efficacy. The capsule dosage form protects the contents from premature destruction by gastric acid in the gastrointestinal tract, allowing the active ingredients to reach the intestines before release, thus improving bioavailability. Furthermore, the fine particle size of each active component after pulverization facilitates intestinal absorption. Each capsule weighs 0.45g, and the recommended dosage is 2 capsules once daily, making it convenient and easy to adhere to. The product uses natural active ingredients, has undergone rigorous safety evaluation and verification, has no obvious side effects, and is suitable for long-term use. The preparation method of this invention uses conventional health food production equipment and processes, with simple steps, convenient operation, and clearly defined and easily controlled process parameters, ensuring product quality stability and suitability for large-scale industrial production.

[0068] Those skilled in the art will understand that embodiments of the present invention can be provided as methods, systems, or computer program products. Therefore, the present invention can take the form of a completely hardware embodiment, a completely software embodiment, or an embodiment combining software and hardware aspects. Furthermore, the present invention can take the form of a computer program product implemented on one or more computer-usable storage media containing computer-usable program code. The storage medium can be implemented by any type of volatile or non-volatile storage device or a combination thereof, such as Static Random Access Memory (SRAM), Electrically Erasable Programmable Read-Only Memory (EEPROM), Erasable Programmable Read-Only Memory (EPROM), Programmable Red-Only Memory (PROM), Read-Only Memory (ROM), magnetic storage, flash memory, magnetic disk, or optical disk. These computer program instructions may also be stored in a computer-readable storage medium that can direct a computer or other programmable data processing device to function in a particular manner, such that the instructions stored in the computer-readable storage medium produce an article of manufacture including instruction means, which are implemented in a process Figure 1 One or more processes and / or boxes Figure 1 The function specified in one or more boxes.

[0069] It should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit it. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention, and all such modifications or substitutions should be covered within the scope of the claims of the present invention.

Claims

1. A capsule formulation for supporting emotional well-being, improving depression and hormone balance, characterized in that, The active ingredients and adjuvants include the following components by weight: Active ingredients: Malaysian flaxseed extract (containing lignans 12%) 3-6 parts, Singapore pumpkin seed concentrate (zinc 4 mg / g) 2-5 parts, Indonesian sesame extract (containing lignans) 1-3 parts, sunflower seed extract (containing vitamin E) 2-4 parts, olive leaf extract (olive secoiridoid compounds 0.5%) 1-3 parts, angelica extract (Singapore processing technology) 2-5 parts, St. John's wort (flavonoids > 2.5%) 3-7 parts, holy berry extract (flavonoids 2.5%) 2-5 parts, South African ashwagandha extract (withanolides 10%) 3-6 parts, 5-hydroxytryptophan (purity > 98%) 0.5-1.5 parts, Suanzaoren extract (total saponins 2%) 2-5 parts, L-theanine 1-3 parts, gamma-aminobutyric acid (90%) 1-4 parts, 5-aminolevulinic acid (5-ALA) 0.5-2 parts, Albizia julibrissin extract 2-5 parts, Zembreen 0.3-1 part; Adjuvants: starch 5-10 parts, magnesium stearate 0.1-0.5 parts; The capsule preparation is a hard capsule, each weighing 0.45 g, and the content of the active ingredients in each capsule is 0.38-0.42 g.

2. The capsule formulation for supporting emotional health, improving depression and hormone balance according to claim 1, wherein: The weight parts of the active ingredients are as follows: Malaysian flaxseed extract (containing lignans 12%) 4-5 parts, Singapore pumpkin seed concentrate (zinc 4 mg / g) 3-4 parts, Indonesian sesame extract (containing lignans) 2 parts, sunflower seed extract (containing vitamin E) 3 parts, olive leaf extract (olive secoiridoid compounds 0.5%) 2 parts, angelica extract (Singapore processing technology) 3-4 parts, St. John's wort (flavonoids > 2.5%) 4-6 parts, holy berry extract (flavonoids 2.5%) 3-4 parts, South African ashwagandha extract (withanolides 10%) 4-5 parts, 5-hydroxytryptophan (purity > 98%) 0.8-1.2 parts, Suanzaoren extract (total saponins 2%) 3-4 parts, L-theanine 2 parts, gamma-aminobutyric acid (90%) 2-3 parts, 5-aminolevulinic acid (5-ALA) 1-1.5 parts, Albizia julibrissin extract 3-4 parts, Zembreen 0.5-0.8 parts.

3. A capsule formulation as described in claim 1 that supports emotional health and improves depression and hormonal balance, characterized in that: The weight parts of the active components are: Malaysia flaxseed extract (containing lignan 12%) 4.5 parts, Singapore pumpkin seed concentrate powder (zinc 4 mg / g) 3.5 parts, Indonesia sesame extract (containing lignan) 2 parts, sunflower seed extract (containing vitamin E) 3 parts, olive leaf extract (olive seco-labdane phenolic compounds 0.5%) 2 parts, angelica extract (Singapore processing technology) 3.5 parts, St. John's wort (flavonoids > 2.5%) 5 parts, holy berry extract (flavonoids 2.5%) 3.5 parts, South African ashwagandha extract (ashwagandha lactones 10%) 4.5 parts, 5-hydroxytryptophan (purity > 98%) 1 part, Suanzaoren extract (total saponins 2%) 3.5 parts, L-theanine 2 parts, gamma-aminobutyric acid (90%) 2.5 parts, 5-aminolevulinic acid (5-ALA) 1.2 parts, Albizia julibrissin extract 3.5 parts, Zembreen 0.6 parts; excipients: starch 7 parts, magnesium stearate 0.3 parts.

4. The capsule formulation according to any one of claims 1 to 3, wherein The Malaysia flaxseed extract is prepared by the following method: taking Malaysia-produced flaxseed, removing impurities and crushing to 40-60 mesh, adding 8-12 times the weight of 70%-80% ethanol solution, refluxing and extracting 2-3 times at 50-60°C, each time for 1.5-2 h, combining the extract, concentrating under reduced pressure until no alcohol taste is left, obtaining the extract, vacuum drying the extract, and crushing to 80-100 mesh to obtain the extract, wherein the lignan content is determined by high performance liquid chromatography to be 12%.

5. The capsule formulation according to any one of claims 1 to 3, wherein The preparation method of the Singapore pumpkin seed concentrate powder is as follows: taking Singapore-produced pumpkin seeds, removing the shells and crushing to 50-70 mesh, adding 6-10 times the weight of deionized water, ultrasonic extracting 1-2 times at 45-55°C, each time for 40-60 min, the ultrasonic power being 300-400 W, combining the extract, centrifuging to obtain the supernatant, spray drying the supernatant, the spray inlet temperature being 180-200°C and the outlet temperature being 80-90°C, obtaining the concentrate powder, and determining the zinc content by atomic absorption spectrophotometry to be 4 mg / g.

6. The capsule formulation according to any one of claims 1 to 3, wherein The angelica extract is prepared by the Singapore processing technology, and the specific steps are as follows: taking angelica decoction pieces, adding yellow rice wine and mixing evenly, the amount of yellow rice wine being 10%-15% of the weight of the angelica decoction pieces, moistening until the yellow rice wine is absorbed, placing in a steaming device, steaming at 105-110°C for 20-30 min, taking out, drying, and crushing to 50-60 mesh, adding 7-9 times the weight of 60%-70% ethanol solution, refluxing and extracting 2 times, each time for 1-1.5 h, combining the extract, and drying by concentration to obtain the extract.

7. The capsule formulation according to any one of claims 1 to 3, wherein The preparation method of the Suanzaoren extract is as follows: taking Suanzaoren, crushing to 40-50 mesh, adding 10-14 times the weight of deionized water, soaking for 2-3 h, and decocting 2-3 times at 90-100°C, each time for 1-1.5 h, combining the decoction, filtering, concentrating the filtrate under reduced pressure to the extract with a relative density of 1.2-1.3 (60°C), vacuum drying, and crushing to 80 mesh to obtain the extract, wherein the total saponin content is determined by ultraviolet spectrophotometry to be 2%.

8. A process for the preparation of a capsule formulation as claimed in any one of claims 1 to 7, characterised in that, The following steps are included: (1) Raw material pretreatment: passing each active component and excipient through a 80-100 mesh sieve to remove impurities and reserve for use; (2) Mixing: firstly, mix the starch and part of the active ingredients uniformly by equal increment method, then add the rest of the active ingredients, mix for 15-20 min, add magnesium stearate, continue mixing for 3-5 min, and obtain the capsule content; (3) Filling: fill the capsule content obtained in step (2) into the empty hard capsule by using automatic capsule filling machine, adjust the filling amount so that the weight of each capsule is 0.45 g, and obtain the primary product; (4) Polishing: put the primary product obtained in step (3) into the capsule polishing machine, polish for 2-3 min, and remove the surface dust; (5) Quality inspection: inspect the polished capsule for weight difference, disintegration time limit, and microbial limit, and the one meeting the standard is the finished product; (6) Packaging: package the qualified finished product 2 capsules per bag, and then put into the packaging box, 28 bags per box, and obtain the product.

9. The production method according to claim 8, wherein In step (2), the relative humidity of the mixing environment is 45%-60%, and the temperature is 18-25℃; in step (5), the weight difference limit is ±7.5%, and the disintegration time limit is ≤30 min.

10. Use of the capsule preparation according to any one of claims 1-7 in the preparation of health food for supporting emotional health, improving depressive state, or regulating hormone balance.

Images