Pulmonary artery interventional therapy guiding catheter

Abstract

The invention relates to the technical field of medical instruments, in particular to a pulmonary artery interventional therapy guiding catheter which comprises a multi-layer cannula assembly, the multi-layer cannula assembly comprises a plurality of cannula parts which become thinner step by step from the first step to the Nth step and are sequentially nested, each cannula part comprises a catheter body, and an operation handle used for controlling the cannula parts is arranged at the near end of each catheter body; the far end of the catheter body is bent relative to the catheter body; the interventional instrument can penetrate through the Nth-step cannula piece so as to reach the target far-end blood vessel under the guidance of the multi-layer cannula assembly. According to the scheme, the defects that in the prior art, due to the fact that a guiding catheter is not matched with a pulmonary artery anatomical structure, the operation difficulty is large, time is long, and radiation exposure is large are overcome, and an interventional access is rapidly built in interventional therapy with complex and bent blood vessels.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medical devices, and particularly relates to a pulmonary artery interventional therapy guide catheter. BACKGROUND

[0002] With the continuous progress of interventional technology, the interventional treatment method of pulmonary vascular lesions has been widely applied and developed, including but not limited to pulmonary arterial hypertension, pulmonary thrombus catheter aspiration, and pulmonary vascular stent thrombectomy and other technologies. These technologies have become an important part of the clinical treatment of pulmonary vascular diseases. Pulmonary arterial hypertension (PAH) is a disease caused by abnormal elevation of pulmonary artery pressure. This pressure rise can cause right heart failure. It can appear as an independent disease or as a complication or syndrome of other diseases. According to the hemodynamic diagnostic criteria, if the right heart catheter detects that the mean pulmonary artery pressure is ≥25mmHg, the pulmonary arteriole wedge pressure is ≤15mmHg, and the pulmonary vascular resistance is >3 Wood units under the resting state at sea level, pulmonary arterial hypertension can be diagnosed. The disease has a high incidence, disability rate and mortality, so it needs to be highly valued in the medical field.

[0003] Chronic thromboembolic pulmonary hypertension (CTEPH) is a special type of pulmonary arterial hypertension caused by fibrosis and remodeling of the pulmonary artery intima after pulmonary embolism. This remodeling is not limited to the original embolism area, but also causes different degrees of remodeling of small pulmonary arteries in the non-occluded area, eventually leading to elevated pulmonary artery pressure and pulmonary vascular resistance, and further causing progressive right heart failure, which can be severely disabling or even fatal. Although the CTEPH patient population is large, there are very limited medical institutions that can provide accurate diagnosis, assessment and treatment services. In particular, for medical institutions that can perform pulmonary endarterectomy (PEA), the number of patients who can receive this surgical treatment is extremely limited. Therefore, for most CTEPH patients, they mainly rely on balloon pulmonary angioplasty (BPA) and drug therapy. However, the effect of drug therapy is not the same, and the cost is high, especially for CTEPH indications such as riociguat, which has a high price, limiting the treatment options for patients, which makes BPA one of the effective means of treating CTEPH.

[0004] BPA is a minimally invasive interventional technique aimed at improving pulmonary perfusion, reducing pulmonary pressure, and improving right heart function by dilating stenotic or occluded pulmonary arteries. The improved BPA technique focuses more on dilating distal arterioles to restore blood supply to the hypoperfused area, thereby optimizing perfusion distribution, improving ventilation / perfusion ratio, and increasing arterial oxygen saturation. Due to the characteristics of blood flow dynamics in the human body, blood flow in the lower lung is usually higher than in the upper lung, which means that BPA can more effectively improve hemodynamics in restoring lower lung perfusion; restoring upper lung perfusion helps improve ventilation / perfusion ratio and further improve arterial oxygen saturation. With the improvement of hemodynamics and arterial oxygen saturation, the efficiency of heart pumping is enhanced, the volume of right ventricle is reduced, the heart function is restored, the exercise tolerance of patients is increased, and the symptoms and signs are gradually improved, ultimately achieving the treatment goal.

[0005] However, the balloon catheter used in the implementation of BPA surgery needs to be inserted from the femoral vein puncture point, passing through a series of complex paths, including through the inferior vena cava, right atrium, right ventricle, and pulmonary artery trunk, and finally reaching the target lesion site. This process involves multiple sharp turns and large-angle bifurcations, especially when the lesion is located in the bilateral upper lung, how to accurately guide the treatment instrument to the target position becomes one of the key challenges for the success of the surgery. The guide catheters currently available on the market for pulmonary vascular intervention, such as peripheral multifunctional catheters (such as MP catheters) or coronary catheters (such as JR3.5), are not completely designed to meet the needs of the pulmonary arterial anatomic structure, which not only increases the difficulty of the surgery, prolongs the surgery time, but also increases the radiation exposure of the doctor and the patient during the surgery. In view of the above situation, it is particularly urgent to develop an interventional guide catheter specially designed for pulmonary arteries and similar complex vascular structures, in order to significantly improve the success rate of the surgery, reduce the surgery time and the risk of radiation exposure, and thus improve the prognosis and quality of life of the patient. SUMMARY

[0006] The present application provides a pulmonary artery interventional therapy guide catheter to solve the defects of the prior art, such as the difficulty of surgery, long surgery time, and multiple radiation exposures caused by the mismatch between the guide catheter and the pulmonary arterial anatomic structure, and to quickly establish an interventional access in interventional therapy with complex and curved blood vessels.

[0007] The present application provides a pulmonary artery interventional therapy guide catheter, comprising: a multi-layer sleeve assembly comprising a plurality of sleeve pieces that are successively nested and tapered from a first stage to an Nth stage, the sleeve piece comprising a catheter body, the proximal end of the catheter body being provided with an operation handle for operating the sleeve piece, the distal end of the catheter body being curved relative to the catheter body; an interventional instrument capable of passing through the sleeve piece of the Nth stage to reach a target distal blood vessel under the guidance of the multi-layer sleeve assembly.

[0008] According to one embodiment of the present application, the inner diameter of the catheter body of any preceding sleeve member is greater than the outer diameter of the catheter body of the following sleeve member; each sleeve member in the multi-layer sleeve assembly has a freedom of independent 360-degree rotation relative to its internal or external adjacent sleeve member.

[0009] According to one embodiment of the present application, the multi-layer sleeve assembly has a bending angle of 1 to 99 degrees at the distal end of the catheter body relative to the catheter body.

[0010] According to one embodiment of the present application, the length of each sleeve member in the multi-layer sleeve assembly increases from the first to the Nth sleeve member.

[0011] According to one embodiment of the present application, the catheter body is provided with a scale mark at one end close to the operating handle; the total length of the scale mark on the catheter body is greater than or equal to the difference between the length of the catheter body and the length of the preceding catheter body.

[0012] According to one embodiment of the present application, the distal end of the catheter body is provided with a developing mark; the developing mark includes a ring-shaped mark surrounding the distal end of the catheter body, and / or the developing mark includes a long-shaped mark extending along the curved shape of the distal end of the catheter body.

[0013] According to one embodiment of the present application, the catheter body has a multi-layer structure, including an inner layer, an outer layer, and an intermediate layer arranged between the inner layer and the outer layer, and the intermediate layer is provided with a mesh anti-twist structure.

[0014] According to one embodiment of the present application, the inner layer is a polytetrafluoroethylene material coating, and the outer layer is made of polyethylene polymer material.

[0015] According to one embodiment of the present application, the interventional instrument includes but is not limited to a guide wire, a balloon catheter, and a stent.

[0016] According to one embodiment of the present application, a locking device is provided, which is provided with a locking mechanism for fixing a plurality of operating handles of the multi-layer sleeve assembly, respectively.

[0017] The pulmonary artery interventional catheter provided by this invention achieves rapid and precise establishment of interventional access in complex and tortuous vascular environments by combining a multi-layered, pre-designed curved cannula assembly with an operating handle. Each cannula layer is designed with a pre-defined curvature that conforms to the typical anatomical features of the pulmonary artery and its branches. From the first to the Nth layer, the length of each cannula gradually increases. The distal end of the preceding catheter body provides guidance for the subsequent catheter body, helping it to accurately align with vascular bends or branches. Furthermore, with the aid of the operating handle, the physician can precisely control the forward and backward movement of the catheter body and the rotation direction of the distal curved structure, ensuring the catheter can move flexibly through different vascular pathways. This effectively reduces potential damage to the vascular wall during the procedure, thereby improving the safety and success rate of the surgery. Attached Figure Description

[0018] To more clearly illustrate the technical solutions in this invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of this invention. For those skilled in the art, other drawings can be obtained from these drawings without creative effort.

[0019] Figure 1 This is a schematic diagram of the pulmonary artery interventional therapy guiding catheter provided by the present invention.

[0020] Figure 2 This is an exploded structural diagram of the multi-layer cannula assembly of the pulmonary artery interventional therapy guiding catheter provided by the present invention.

[0021] Figure 3 This is a schematic diagram of the sheath of the pulmonary artery interventional therapy guiding catheter provided by the present invention.

[0022] Figure 4 This is a schematic diagram of the multi-layer structure of the catheter body of the pulmonary artery interventional therapy guiding catheter provided by the present invention.

[0023] Figure label: 11. Catheter body; 12. Operating handle; 13. Scale markings; 14. Imaging markers; 15. Inner layer; 16. Outer layer; 17. Intermediate layer; 18. Mesh anti-torsion structure; 20. Interventional device. Detailed Implementation

[0024] To make the objectives, technical solutions, and advantages of this invention clearer, the technical solutions of this invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some, not all, of the embodiments of this invention. All other embodiments obtained by those skilled in the art based on the embodiments of this invention without creative effort are within the scope of protection of this invention.

[0025] In the description of the embodiments of the present invention, it should be noted that the terms "center," "longitudinal," "lateral," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," and "outer," etc., indicating the orientation or positional relationship, are based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing the embodiments of the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on the embodiments of the present invention. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and should not be construed as indicating or implying relative importance. It should also be noted that in the description of the present invention, unless otherwise explicitly specified and limited, the terms "set," "install," and "connect" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection. Those skilled in the art can understand the specific meaning of the above terms in the present invention according to the specific circumstances.

[0026] In existing technologies, the guiding catheter is incompatible with the pulmonary artery anatomy, leading to increased surgical difficulty, longer operation time, and greater radiation exposure. To address these issues, this invention provides a guiding catheter for pulmonary artery interventional treatment. This guiding catheter employs a ladder-like design, featuring extendability and 360-degree rotational guidance, specifically designed for rapidly establishing interventional access in complex and tortuous vessels such as the pulmonary artery.

[0027] The following is combined with Figures 1 to 4 The following describes a specific embodiment of the pulmonary artery interventional therapy guiding catheter of the present invention. It should be understood that the pulmonary artery interventional therapy guiding catheter is actually a long product, and the accompanying drawings in the specification use an abbreviated drawing method for clarity.

[0028] like Figure 1 and Figure 2As shown, this invention provides a pulmonary artery interventional therapy guiding catheter, comprising: a multi-layer cannula assembly, including multiple cannula pieces that are progressively thinner and nested from the first to the Nth layer, each cannula piece including a catheter body 11, with an operating handle 12 for manipulating the cannula piece at the proximal end of the catheter body 11, and the distal end of the catheter body 11 being curved relative to the catheter body 11; and an interventional device 20, which can pass through the Nth layer of cannula pieces to reach the target distal blood vessel under the guidance of the multi-layer cannula assembly. This pulmonary artery interventional therapy guiding catheter, by employing a multi-layer pre-designed curvature, combined with the advance, retreat, and rotation control of the operating handle 12, achieves the goal of rapidly and accurately establishing an interventional pathway in complex and curved vascular environments.

[0029] Specifically, each layer of the cannula is designed with the same or different preset curvatures, which are customized based on the typical anatomical features of the pulmonary artery and its branches. According to a pulmonary artery interventional therapy guiding catheter of the present invention, the multi-layer cannula assembly, from the first to the Nth layer, has each cannula increasing in length progressively. The distal end of the preceding catheter body 11 can guide the subsequent catheter body 11, turning it to align with a vascular bend or branch. The forward and backward movement of the catheter body 11 can be controlled by the operating handle 12, and the orientation of the distal curved structure of the catheter body 11 can be changed by rotating the operating handle 12, ensuring that the catheter can flexibly adapt to different vascular pathways, reducing damage to the vascular wall during the procedure, and improving the safety and success rate of the procedure.

[0030] In practical use, the doctor first selects the appropriate guiding catheter model based on the patient's specific condition and the anatomical characteristics of the pulmonary artery. Then, starting from the femoral vein puncture point, the guiding catheter is gradually advanced along the predetermined path to the pulmonary artery. The operating handle 12 is used to finely adjust the advance and retreat positions and rotation angles of each layer of the catheter body 11, allowing the catheter to smoothly pass through the various bends of the pulmonary artery until it reaches the target lesion site. Through multi-stage guidance, the interventional device 20 (such as a guidewire) is finally guided to the target distal vessel under the guidance of the multi-layer cannula assembly. Subsequently, the interventional device 20 is inserted through the innermost cannula 15 to complete the corresponding treatment procedure, such as balloon dilation or stent implantation.

[0031] Furthermore, the multi-layer cannula assembly of the aforementioned pulmonary artery interventional therapy guiding catheter can be specifically designed with 3 to 5 layers, with the diameter of each layer decreasing progressively. For example, the first-stage cannula has the largest diameter and is mainly used for initial entry and preliminary guidance; the diameters of the second to Nth stages (N=3, 4, or 5) cannulas gradually decrease, and the distal end of each cannula can be more precisely steered under the guidance of the previous stage cannula, ultimately guiding the interventional device 20 to the target distal blood vessel.

[0032] The distal pre-designed curvature of each of the aforementioned cannula fittings can be customized based on the typical anatomical features of the pulmonary artery and its branches. For example, the distal end of the first-order cannula fitting can be designed with a larger curvature to accommodate the tortuosity of the main pulmonary artery; the distal end of the second-order cannula fitting can be designed with a medium curvature to accommodate the major branches of the pulmonary artery; and the distal ends of the third-order and deeper cannula fittings can be designed with a smaller curvature to accommodate smaller, more distal branches. These pre-designed curvatures help provide better guidance and support at vascular bends or branching points.

[0033] Furthermore, the catheter body 11 is preferably made of medical-grade materials with high flexibility and good biocompatibility, such as polyurethane or nylon, to ensure safety and comfort in complex vascular environments. Simultaneously, the catheter surface can be treated with a hydrophilic coating to reduce friction and improve delivery performance.

[0034] According to a pulmonary artery interventional therapy guiding catheter of the present invention, in the first to Nth stages of the cannula, the inner diameter of the catheter body 11 of any preceding stage cannula is larger than the outer diameter of the catheter body 11 of the subsequent stage cannula; in the multi-layer cannula assembly, each cannula has an independent 360-degree rotational freedom relative to its internal or external adjacent stage cannula. This dimensional design ensures that each layer of cannula can freely rotate and turn under the guidance of the preceding stage cannula, thereby allowing for more precise alignment with bends or branches of the blood vessel.

[0035] Specifically, in the first to Nth stage of the cannula, the inner diameter of the catheter body 11 of any preceding stage cannula is larger than the outer diameter of the catheter body 11 of the following stage cannula. This ensures that each layer of the cannula can be smoothly nested inside the preceding stage cannula, while leaving sufficient space for the following stage cannula to move and rotate freely. The independent 360-degree rotational freedom of each cannula layer allows the surgeon to precisely adjust the rotation angle of each layer using the operating handle 12, ensuring that the catheter can be accurately aligned with the bends or branches of the blood vessel. This precise guiding capability helps the guiding catheter smoothly navigate complex vascular pathways to reach the target lesion. Because each layer of the cannula can rotate independently, the guiding catheter can more gently adjust its direction when passing through bends or branches of the blood vessel, reducing friction and damage to the vessel wall and improving the safety of the procedure.

[0036] In a preferred embodiment of the pulmonary artery interventional therapy guiding catheter according to the present invention, in the multi-layer cannula assembly, the distal end of the catheter body 11 has a bending angle of 1 to 99 degrees relative to the catheter body 11. Specifically, the pulmonary artery and its branches have complex anatomical structures, including multiple bends and bifurcations. Designing the distal bending angle of the catheter body 11 to be 1 to 99 degrees allows for better adaptation to these complex vascular pathways depending on the actual application scenario. For example, a smaller bending angle (e.g., 1 to 30 degrees) is suitable for gentler bends, while a larger bending angle (e.g., 60 to 99 degrees) is suitable for sharper bends or branching. Through layer-by-layer guidance of the multi-layer cannula assembly, the distal bending angles of each layer can cooperate to achieve precise navigation of complex vascular pathways. The multi-level guiding design enables the guiding catheter to more flexibly handle various vascular morphologies, improving the accuracy and reliability of guidance.

[0037] Furthermore, preoperative imaging examinations (such as CTA or MRI) allow doctors to gain a detailed understanding of the patient's pulmonary artery anatomy, enabling them to pre-design and manufacture suitable cannulas. Cannulas with varying bend angles can be customized based on each patient's specific condition and the anatomical characteristics of the pulmonary artery. For example, if the lesion is located in a specific branch of the pulmonary artery, doctors can customize a cannulas with a corresponding bend angle based on the distal bend angle of the catheter body 11 of that branch, ensuring the guiding catheter reaches the target location more precisely.

[0038] On the other hand, to meet the needs of different cases, multiple cannulas of the same size but different models can be prefabricated. Each model has the same dimensions but different distal curvatures. For example, cannulas with bending angles of 10 degrees, 30 degrees, 60 degrees, and 90 degrees can be prefabricated to cover common vascular bends and branches. In actual surgery, surgeons can quickly select the most suitable cannulas model based on the actual intraoperative situation. This prefabricated, standardized design not only saves surgical preparation time but also improves the flexibility and efficiency of the surgery.

[0039] like Figure 3As shown, in a pulmonary artery interventional therapy guiding catheter according to the present invention, a scale marking 13 is provided at one end of the catheter body 11 near the operating handle 12; the total length of the scale marking 13 on the catheter body 11 is greater than or equal to the difference in length between the catheter body 11 and the previous catheter body 11. Specifically, the scale marking 13 allows the physician to more precisely control the advancement depth and position of each cannula during the operation. Preferably, the total length of the scale marking 13 is greater than or equal to the difference in length between the catheter body 11 and the previous catheter body 11, ensuring that the physician can clearly determine the relative position of each cannula through the scale marking 13, thereby enabling more accurate multi-stage guidance. This precise control not only improves the accuracy and safety of the surgery but also reduces vascular damage and other complications caused by improper operation, improving the success rate of the surgery and the patient's treatment outcome.

[0040] Furthermore, according to a pulmonary artery interventional therapy guiding catheter of the present invention, a contrast marker 14 is provided at the distal end of the catheter body 11; the contrast marker 14 includes a ring-shaped marker that surrounds the distal end of the catheter body 11 in a circular pattern, and / or the contrast marker 14 includes an elongated marker extending along the curved shape of the distal end of the catheter body 11. Specifically, through the contrast marker 14, the physician can clearly observe the position and orientation of the distal end of the catheter during the operation using X-rays or other imaging equipment, thereby performing the operation more precisely. The ring-shaped marker helps the physician determine the overall position of the distal end of the catheter, while the elongated marker can show the direction and degree of curvature of the distal end of the catheter, ensuring that the catheter can be accurately aligned with the bend or branch of the blood vessel. This embodiment not only improves the visualization of the operation but also enhances the precision and safety of the operation, reduces vascular damage and other complications caused by inaccurate positioning, and improves the success rate of the operation and the treatment effect for the patient.

[0041] like Figure 4 As shown, according to a pulmonary artery interventional therapy guiding catheter of the present invention, the catheter body 11 has a multi-layer structure, including an inner layer 15, an outer layer 16, and an intermediate layer 17 disposed between the inner layer 15 and the outer layer 16. The intermediate layer 17 is provided with a mesh anti-torsion structure 18. The mesh anti-torsion structure 18 can significantly improve the torsional performance and overall stability of the guiding catheter, ensuring that the catheter will not lose control or be damaged due to torsion in complex vascular environments. Specifically, the mesh anti-torsion structure 18 is evenly distributed in the intermediate layer 17, ensuring that the torsional performance of the catheter is consistent in all directions. Based on the mesh anti-torsion structure 18, the pushing, pulling, and rotational forces applied by the doctor through the operating handle 12 can be effectively transmitted, ensuring that each layer of the cannula can be operated in the expected direction and with the expected force.

[0042] The mesh-like anti-torsion structure 18 can be a woven wire mesh, a polymer fiber mesh, or a composite material mesh. Among these, the woven wire mesh possesses excellent mechanical strength and torsional resistance, effectively preventing the catheter from twisting during advancement and rotation. The polymer fiber mesh offers good biocompatibility and flexibility, providing moderate torsional support. The composite material mesh combines the advantages of both wire and polymer fibers, exhibiting high strength and torsional resistance while also possessing good flexibility and biocompatibility.

[0043] Furthermore, according to the present invention, the inner layer 15 of the pulmonary artery interventional catheter is coated with polytetrafluoroethylene (PTFE), and the outer layer 16 is made of polyethylene polymer material. Specifically, the PTFE coating of the inner layer 15 has an extremely low coefficient of friction, which can significantly reduce the friction inside the catheter, making the catheter body 11 or interventional device 20 (such as guidewire, balloon catheter, or stent delivery system) pass through the catheter more smoothly, reducing advancement resistance and improving the convenience and efficiency of the operation. The polyethylene polymer material of the outer layer 16 has good flexibility, can adapt to complex vascular pathways, reduce damage to the vascular wall, and has good biocompatibility, and will not cause immune response or inflammation in the body.

[0044] According to the present invention, a pulmonary artery interventional therapy guiding catheter includes, but is not limited to, guidewires, balloon catheters, stents, and any other interventional devices. Specifically, in conjunction with the aforementioned pulmonary artery interventional therapy guiding catheter, the physician first selects a suitable guiding catheter model based on the patient's specific condition and the anatomical characteristics of the pulmonary artery. Starting from the femoral vein puncture point, the guiding catheter is gradually advanced along a predetermined path to the pulmonary artery. The operating handle 12 is used to finely adjust the advance and retreat positions and rotation angles of each layer of the catheter body 11, allowing the catheter to smoothly pass through various bends in the pulmonary artery until it approaches the target lesion site. Subsequently, the appropriate interventional device 20 is selected as needed: when inserting a guidewire, the guidewire is guided to the target lesion site through the innermost sheath 15, ensuring accurate arrival at the target location; when using a balloon catheter, the balloon catheter is inserted through the innermost sheath 15, and after reaching the target location, it is inflated to dilate the narrowed or occluded vessel; when using a stent, the stent delivery system is inserted through the innermost sheath 15, and after reaching the target location, the stent is released to support the narrowed or occluded vessel. Throughout the procedure, doctors can monitor the position of the guiding tube and interventional device 20 in real time using X-rays or other imaging equipment to ensure the accuracy and safety of the operation.

[0045] A pulmonary artery interventional therapy guiding catheter according to the present invention includes a locking device, which is provided with a locking mechanism for respectively fixing multiple operating handles 12 of a multi-layer cannula assembly. Specifically, the locking device can ensure that each layer of the cannula remains fixed when needed, improving the stability and safety of the procedure. During the operation, the surgeon can more precisely control the position and orientation of each layer of the cannula through the locking device, preventing errors caused by accidental movement during the procedure. The locking device may specifically include multiple clamps or similar forms arranged in the arrangement direction of the multiple operating handles 12 of the multi-layer cannula assembly. These clamps can firmly fix the operating handles 12 to the worktable when needed, ensuring that each layer of the cannula remains in a predetermined position during the procedure, thereby improving the accuracy and safety of the procedure.

[0046] In the description of this specification, the references to terms such as "one embodiment," "some embodiments," "method," "specific method," or "some methods," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or method is included in at least one embodiment or method of the present invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or method. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or methods. Moreover, without contradiction, those skilled in the art can combine and integrate the different embodiments or methods described in this specification, as well as the features of different embodiments or methods.

[0047] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, and not to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some of the technical features; and these modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A guiding catheter for pulmonary artery interventional therapy, characterized in that, include: A multi-layer cannula assembly includes multiple cannula components that are progressively thinner and nested in sequence from the first to the Nth stage. Each cannula component includes a catheter body (11). The proximal end of the catheter body (11) is provided with an operating handle (12) for manipulating the cannula component. The distal end of the catheter body (11) is curved relative to the catheter body (11). Interventional device (20), which is capable of passing through the Nth-level cannula to reach the target distal blood vessel under the guidance of the multilayer cannula assembly.

2. The pulmonary artery interventional therapy guiding catheter according to claim 1, characterized in that, In the sleeves from the first to the Nth order, the inner diameter of the conduit body (11) of any previous order sleeve is greater than the outer diameter of the conduit body (11) of the subsequent order sleeve. In the multi-layer sleeve assembly, each sleeve member has an independent 360-degree rotational freedom relative to its internal or external adjacent sleeve members.

3. The pulmonary artery interventional therapy guiding catheter according to claim 1, characterized in that, In the multi-layer cannula assembly, the distal end of the catheter body (11) has a bending angle of 1 to 99 degrees relative to the catheter body (11).

4. The pulmonary artery interventional therapy guiding catheter according to claim 1, characterized in that, The length of each sleeve component in the multi-layer sleeve assembly increases progressively from the first to the Nth stage.

5. The pulmonary artery interventional therapy guiding catheter according to claim 4, characterized in that, The catheter body (11) has a scale mark (13) at one end near the operating handle (12); The total length of the scale markings (13) on the catheter body (11) is greater than or equal to the difference in length between the catheter body (11) and the previous catheter body (11).

6. The pulmonary artery interventional therapy guiding catheter according to claim 4, characterized in that, The distal end of the catheter body (11) is provided with a radiopaque marker (14). The imaging mark (14) includes a ring-shaped mark that is circular around the distal end of the catheter body (11), and / or the imaging mark (14) includes an elongated mark that extends in a curved shape along the distal end of the catheter body (11).

7. The pulmonary artery interventional therapy guiding catheter according to any one of claims 1 to 6, characterized in that, The catheter body (11) has a multi-layer structure, including an inner layer (15), an outer layer (16) and an intermediate layer (17) disposed between the inner layer (15) and the outer layer (16), wherein the intermediate layer (17) is provided with a mesh anti-torsion structure (18).

8. The pulmonary artery interventional therapy guiding catheter according to claim 7, characterized in that, The inner layer (15) is a polytetrafluoroethylene coating, and the outer layer (16) is made of polyethylene polymer material.

9. The pulmonary artery interventional therapy guiding catheter according to any one of claims 1 to 6, characterized in that, The interventional device (20) includes, but is not limited to, guidewire, balloon catheter, and stent.

10. The pulmonary artery interventional therapy guiding catheter according to any one of claims 1 to 6, characterized in that, Includes a locking device, which is provided with a locking mechanism for securing a plurality of operating handles (12) of the multilayer sleeve assembly respectively.

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