Composition for emotion regulation and pressure relief as well as preparation method and application thereof

Abstract

The invention discloses a composition for emotion regulation and pressure relief as well as a preparation method and application thereof, and belongs to the technical field of health-care food. The composition is prepared by differentiated pretreatment processes of GABA-turmeric co-coating granulation, passionflower and lemon balm double-layer coating and tea leaf theanine quick release treatment. According to the composition for emotion regulation and pressure relief as well as the preparation method and the application of the composition, a multi-target synergistic system of absorption synergy, nerve regulation and fatigue repair is constructed; the bioavailability of the gamma-aminobutyric acid and other core components is remarkably improved, meanwhile, the anti-inflammatory and anti-oxidation functions are achieved, the dual effects of improving sleep and relieving fatigue are enhanced, and therefore the effects of emotion regulation and pressure relieving are achieved.

Description

Technical Field

[0001] This invention relates to the field of health food technology, and in particular to a composition for mood regulation and stress relief, its preparation method and application. Background Technology

[0002] With the accelerating pace of society and increasing work pressure, emotional problems such as anxiety, depression, and insomnia are becoming increasingly common. Currently, the main intervention methods include psychological counseling and medication. However, medication often carries risks such as dependence and side effects, while psychological counseling is time-consuming and costly. Therefore, consumer demand for safe, effective, and convenient daily mood-regulating foods is growing.

[0003] Currently, the relevant products on the market are mainly divided into three categories, but all of them have obvious technical defects: Chemically synthesized sleep aids, such as benzodiazepines and zolpidem, can induce sleep quickly, but they have side effects such as drowsiness the next day, drug dependence, and liver and kidney damage. Moreover, they only target sleep problems and cannot relieve fatigue at the same time, thus limiting their applicable scenarios.

[0004] Single-ingredient natural products, such as melatonin, GABA (gamma-aminobutyric acid), and jujube seed extract, while generally safe, have limited effects and low bioavailability. For example, oral GABA is easily degraded by stomach acid, with an intestinal absorption rate of less than 20%; long-term use of melatonin may lead to endocrine disorders and has little effect on stress-related sleep disorders.

[0005] Traditional herbal compound products: mostly composed of Chinese herbs such as jujube seed and poria cocos. Although they can help with sleep and calm the nerves, they have problems such as complex ingredients, unclear mechanism of action, bitter taste, and slow onset of action (requiring continuous use for 1-2 months). They are difficult to meet the needs of modern consumers for rapid onset of action and a good experience. Summary of the Invention

[0006] The purpose of this invention is to provide a composition for mood regulation and stress relief, its preparation method and application. It constructs a multi-target synergistic system of absorption enhancement, neuromodulation and fatigue repair, which significantly improves the bioavailability of core components such as γ-aminobutyric acid while also having anti-inflammatory and antioxidant functions. It achieves the dual effects of improving sleep and relieving fatigue, thereby realizing the effects of mood regulation and stress relief.

[0007] To achieve the above objectives, the present invention provides a composition for mood regulation and stress relief, comprising, by weight percentage, the following ingredients: 15-20% γ-aminobutyric acid, 8-12% passionflower extract, 5-8% tea theanine, 2-4% lemon balm extract, 1-2% turmeric extract, 45-55% sorbitol, 10-12% microcrystalline cellulose, 0.8-1.2% magnesium stearate, 1-2% chamomile flavor, and 0.1-0.2% sucralose.

[0008] The present invention also provides a method for preparing the above-described composition for mood regulation and stress relief, comprising the following steps: Step 1: Prepare GABA-turmeric synergistic granules by double-coating passionflower extract and lemon balm extract to obtain double-layer encapsulated microcapsules and by rapidly releasing theanine from tea leaves to obtain a rapid-release mixture. Step 2: Premix chamomile flavoring with a portion of sorbitol to obtain flavoring-sorbitol premixed powder, wherein the portion of sorbitol accounts for 5-10% of the total sorbitol content; Step 3: Add all of the GABA-turmeric synergistic granules, double-layer encapsulated microcapsules and immediate-release mixture, flavor-sorbitol premix powder, remaining sorbitol, remaining microcrystalline cellulose, sucralose and magnesium stearate into a three-dimensional mixer and mix to obtain the final mixture. Step 4: Feed the final mixture into a rotary tablet press for tableting. The tablets are then sealed in aluminum foil.

[0009] Preferably, the specific operation of step one is as follows: T1. GABA-turmeric synergistic granules were obtained by premixing γ-aminobutyric acid and turmeric extract, using fluidized bed bottom spray coating technology and maltodextrin solution with a solid content of 28-32% as coating material. T2. Passion fruit extract and lemon balm extract are premixed, and a compound aqueous solution of sodium alginate and chitosan is used as a coating material. The premixed passion fruit extract and lemon balm extract are coated once through a fluidized bed to form an enteric layer on the surface of the premixed passion fruit extract and lemon balm extract. T3. The premixed passion fruit extract and lemon balm extract that have undergone one coating in T2 are used in fluidized bed melt coating technology and hydrogenated vegetable oil is used for a second coating to form a flavor masking layer on the surface of the enteric layer, finally obtaining double-layer encapsulated herbal microcapsules. T4. Theanine from tea leaves and a portion of microcrystalline cellulose are added to a three-dimensional mixer for mixing, wherein the portion of microcrystalline cellulose accounts for 5% of the total amount of microcrystalline cellulose.

[0010] Preferably, in T1, the coating weight gain rate is 5-8%, and the fluidized bed parameters are: inlet temperature 55-65℃, outlet temperature 35-45℃, atomization pressure 0.2-0.3MPa. After granulation, the product is passed through a 30-mesh sieve to obtain GABA-turmeric synergistic granules. The dry weight of maltodextrin in the maltodextrin solution is the total weight of γ-aminobutyric acid and turmeric extract × coating weight gain rate.

[0011] Preferably, in T2, the pH of the coating solution is 5.5-6, the stirring time is 30-40 min, the rotation speed is 300-350 rpm, the weight gain of the enteric coating is 8-12%, the fluidized bed parameters are the same as those in T1, and the amount of sodium alginate and chitosan compound aqueous solution is the sum of passion fruit extract and lemon balm extract × the weight gain of the enteric coating.

[0012] Preferably, in T3, the weight gain rate of the flavor-masking layer coating is 3-5%, the melt coating temperature is 68-72℃, and the amount of hydrogenated vegetable oil used is the total weight of γ-aminobutyric acid, turmeric extract and flavor-masking layer × the weight gain rate of the flavor-masking layer coating.

[0013] Preferably, in T4, the mixing speed is 15-20 rpm and the mixing time is 10-15 min.

[0014] Preferably, in step three, the rotation speed of the three-dimensional mixer is 15-20 rpm, and the mixing time is 20-25 min.

[0015] Preferably, in step four, the parameters for compression molding are: relative humidity ≤55%, temperature 20-30℃, tablet weight 1g / tablet, and hardness 40-50N.

[0016] The present invention also provides the application of the above-described mood regulation and stress relief composition in the preparation of food products that regulate mood and relieve stress.

[0017] Therefore, the present invention, employing the above-mentioned composition for mood regulation and stress relief, its preparation method, and its application, has the following beneficial effects: (1) Turmeric extract (high-purity curcumin) achieves "two-way synergistic value". On the one hand, it significantly improves the bioavailability of core components such as GABA and passionflower flavonoids by inhibiting intestinal glucuronyl transferase, and the synergistic effect is clear; on the other hand, its own anti-inflammatory and antioxidant properties can directly act on the body, help to clear free radicals generated by stress and fatigue, support the recovery of nerve and muscle function, and provide triple protection of sleep optimization, immediate relief and fatigue repair, accurately matching the complex needs of sub-healthy people, thereby achieving the effects of mood regulation and stress relief; (2) The co-coating process in step T1 ensures that GABA and turmeric extract are released simultaneously at the intestinal absorption site, so that curcumin can act efficiently on the absorption channel and minimize the degradation of GABA by gastric acid and first-pass metabolism in the intestine. This design, combined with the rapid release characteristics of theanine in tea (which helps to quickly induce relaxation α brain waves) and the colon-targeted release technology of herbal ingredients, jointly constructs a cascade effect mode of rapid soothing-continuous sleep aid-long-term repair, which effectively improves the problems of slow onset and short duration of action in traditional products. (3) As a traditional Chinese medicine and food ingredient with a long history, turmeric has a high level of safety. Animal toxicology experiments and human trials have verified that there is no risk of drug dependence or drowsiness the next day, and the safety is high. At the same time, turmeric extract itself has no odor. Combined with double-layer coating process and chamomile flavoring, the product has a mild and pure taste, which significantly improves consumer acceptance.

[0018] The technical solution of the present invention will be further described in detail below through embodiments. Detailed Implementation

[0019] The technical solution of the present invention will be further described below through embodiments.

[0020] Unless otherwise defined, the technical or scientific terms used in this invention shall have the ordinary meaning as understood by one of ordinary skill in the art to which this invention pertains.

[0021] Example 1 This invention provides a composition for mood regulation and stress relief, comprising the following ingredients: 170g γ-aminobutyric acid, 100g passionflower extract, 60g tea theanine, 30g lemon balm extract, 15g turmeric extract, 500g sorbitol, 110g microcrystalline cellulose, 10g magnesium stearate, 15g chamomile flavor, and 1.5g sucralose.

[0022] Before pretreatment of all raw materials, the moisture content must be controlled to ≤5% to ensure powder flowability and stability.

[0023] A method for preparing a mood-regulating and stress-relieving composition includes the following steps: Step 1: Prepare GABA-turmeric synergistic granules by double-coating passionflower extract and lemon balm extract to obtain double-layer encapsulated microcapsules and by rapidly releasing theanine from tea leaves to obtain a rapid-release mixture. T1. Premix: Weigh out γ-aminobutyric acid and turmeric extract according to the formula, put them into a three-dimensional mixer, and mix at 25 rpm for 10 minutes to ensure uniform mixing.

[0024] Preparation of coating solution: Dissolve food-grade maltodextrin in purified water to prepare a maltodextrin solution with a solid content of 30%, and stir until completely dissolved and free of particles.

[0025] Fluidized bed bottom spray coating: The premixed powder is fed into the fluidized bed bottom spray coating machine. The parameters are set as follows: inlet temperature 60℃, outlet temperature 40℃, atomization pressure 0.25MPa, and fan frequency 35Hz. The maltodextrin solution is sprayed in at a uniform speed, and the coating weight gain is controlled at 6%.

[0026] Post-processing: After coating, the granules are removed, passed through a 30-mesh sieve, and large particles and fine powder are removed to obtain GABA-turmeric synergistic granules with good flowability and an angle of repose ≤32°.

[0027] T2. Premix: Weigh passion fruit extract and lemon balm extract according to the formula, put them into a three-dimensional mixer, and mix at 18 rpm for 12 minutes.

[0028] Preparation of coating solution: Dissolve sodium alginate (3% concentration) and chitosan (1% concentration) in purified water, adjust the pH to 5.5-6.0 with dilute hydrochloric acid or sodium hydroxide, and stir at 320 rpm for 35 min to ensure the formation of a homogeneous compound solution.

[0029] Fluidized bed coating: The premixed herbal powder is put into the fluidized bed and sprayed in the top spray mode with the same parameters as T1 (inlet temperature, outlet temperature, and atomization pressure). The coating liquid is sprayed in until the weight gain reaches 10% to form an enteric layer.

[0030] T3. Melting preparation: Add food-grade hydrogenated vegetable oil to the melting tank, control the temperature at 78℃, and stir until completely melted into a transparent liquid.

[0031] Fluidized bed melt coating: The premixed passion fruit extract and lemon balm extract that have undergone one coating in T2 are put into the fluidized bed. The temperature of the material bed is kept stable between 68-75℃ by hot air circulation. Molten hydrogenated vegetable oil is sprayed in at a uniform speed, and the coating weight gain rate is controlled at 4%. The particle temperature is not lower than 68℃ during the coating process.

[0032] Cooling and shaping: After coating, the capsules are naturally cooled to room temperature to obtain double-layered embedded herbal microcapsules.

[0033] T4. Weigh out the theanine from the tea leaves and 5% of the total amount of microcrystalline cellulose, put them into a three-dimensional mixer, and mix at 18 rpm for 12 minutes to obtain an immediate-release mixture.

[0034] Step 2: Weigh out the amount of chamomile flavoring according to the formula, and put it into a small mixer along with sorbitol (8% of the total sorbitol content). Mix at 30 rpm for 5 minutes to make a homogeneous flavoring-sorbitol premixed powder.

[0035] Step 3: Add all of the GABA-turmeric synergistic granules, double-layer encapsulated microcapsules and immediate-release mixture, flavor-sorbitol premix powder, remaining sorbitol, remaining microcrystalline cellulose, sucralose and magnesium stearate into a three-dimensional mixer and mix at 20 rpm for 20 minutes to obtain the final mixture. After mixing, measure the angle of repose of the material. If it is >32°, add 0.3-0.5% food-grade silica and mix for an additional 5 minutes until the angle of repose is ≤32° to obtain the final mixture.

[0036] Step 4: Feed the final mixture into a rotary tablet press for tableting. Seal the compressed tablets with aluminum foil. The tableting workshop must maintain a relative humidity of ≤55% and a temperature of 25℃ to prevent moisture absorption by the materials. Feed the final mixture into the rotary tablet press, set the tablet weight to 1.0g / tablet, hardness to 45N, and tableting speed to 30 tablets / minute. Ensure the tablet surface is smooth and free of cracks. Immediately after compression, package the tablets in aluminum-plastic blister packs (aluminum foil thickness ≥0.02mm), 10 tablets per blister pack. After packaging, perform a sealing test to ensure no air leakage. Store away from light.

[0037] Example 2 The only difference between this embodiment and Embodiment 1 is that the composition in Embodiment 2 includes the following ingredients: 150g of γ-aminobutyric acid, 120g of passionflower extract, 80g of tea theanine, 40g of lemon balm extract, 20g of turmeric extract, 450g of sorbitol, 120g of microcrystalline cellulose, 12g of magnesium stearate, 20g of chamomile flavoring, and 2g of sucralose.

[0038] In terms of preparation process, T1 coating increased weight by 8%, T2 by 12%, T3 by 5%, maltodextrin solution by 32%, fluidized bed parameters: inlet 65℃, outlet 45℃, atomization pressure 0.3MPa, and all other conditions were the same.

[0039] Example 3 The only difference between this embodiment and Example 1 is that the composition in Example 3 includes the following ingredients: 200g of γ-aminobutyric acid, 80g of passionflower extract, 50g of tea theanine, 20g of lemon balm extract, 10g of turmeric extract, 550g of sorbitol, 100g of microcrystalline cellulose, 8g of magnesium stearate, 10g of chamomile flavoring, and 1g of sucralose.

[0040] In terms of preparation process, T1 coating increased weight by 5%, T2 by 8%, T3 by 3%, maltodextrin solution by 28%, fluidized bed parameters: inlet 55℃, outlet 35℃, atomization pressure 0.2MPa, and all other conditions were the same.

[0041] Example 4 The only difference between this embodiment and Example 1 is that the composition in Example 4 includes the following ingredients: 180g of γ-aminobutyric acid, 90g of passionflower extract, 70g of tea theanine, 25g of lemon balm extract, 12g of turmeric extract, 490g of sorbitol, 105g of microcrystalline cellulose, 9g of magnesium stearate, 14g of chamomile flavoring, and 1.3g of sucralose.

[0042] In terms of preparation process, T1 coating increased weight by 7%, T2 by 9%, and T3 by 4%, with 30% maltodextrin solution. Fluidized bed parameters were: inlet 60℃, outlet 40℃, and atomization pressure 0.25MPa. All other conditions were the same.

[0043] Comparative Example 1 The only difference between this comparative example and Example 1 is that the raw materials of the composition in Comparative Example 1 do not contain turmeric extract, and sorbitol is added to make up to 515g, while all other conditions are the same.

[0044] Comparative Example 2 The only difference between this comparative example and Example 1 is that Comparative Example 2 does not include the operation step T1; all other conditions are the same.

[0045] Comparative Example 3 The only difference between this comparative example and Example 1 is that the raw materials of the composition in Comparative Example 3 do not contain passion fruit extract and lemon balm extract, and sorbitol is added to make up to 630g, while all other conditions are the same.

[0046] Performance Investigation: 1. Toxicity testing: A blank control group (physiological saline) and experimental groups (Examples 1-4) were set up, with 20 mice in each group (weighing 20±2g, half male and half female). The experimental groups were administered the drug by gavage at a dose of 5000mg / kg·d (far exceeding the recommended daily dose for humans by 10 times, used to verify the safety margin of acute toxicity). The specific administration regimen was as follows: the composition was prepared into a homogeneous suspension of 200mg / mL using purified water and 0.5% sodium carboxymethyl cellulose (suspending agent), and administered by gavage twice daily (once in the morning and once in the evening), with a single gavage volume of 0.25mL / mouse (corresponding to a single dose of 50mg / mouse), for 14 consecutive days. One hour after gavage, mice were observed for any abnormal signs such as vomiting, reflux, or lethargy. Weight changes were recorded daily. Liver and kidney function indicators were measured at the end of the experiment. (Optimization notes: By dividing the gavage into multiple administrations, the single volume was controlled at 0.25mL, far below the upper limit of safe gavage for mice; the suspending agent ensured the drug solution was homogeneous and free of precipitation, avoiding needle blockage and excessive local concentration irritating the gastrointestinal tract). The results are shown in Table 1.

[0047] Table 1 Experimental Results

[0048] As shown in Table 1, the mice in the experimental groups of Examples 1-4 did not experience any adverse reactions related to gavage (such as reflux or abnormal weight loss), and the mortality rate within 14 days was 0. Combined with liver and kidney function indicators and weight change data, it was confirmed that the composition had no acute toxicity, no adverse effects on the physiological functions of mice, and its safety met food-grade requirements.

[0049] 2. Sleep Improvement and Fatigue Relief Test: 2.1 Sleep Improvement Experiment: A blank control group, comparative groups 1-3, and example groups 1-4 were set up, with 20 mice in each group. After 7 consecutive days of gavage, mice were injected intraperitoneally with a subthreshold dose of sodium pentobarbital (30 mg / kg), and the sleep rate (loss of righting reflex ≥ 1 min) was recorded; mice were then injected with a threshold dose of sodium pentobarbital (50 mg / kg), and the sleep time (time from loss of righting reflex to recovery) was recorded.

[0050] 2.2 Fatigue relief test: After 7 days of continuous gavage, mice were given a lead weight of 5% of their body weight and their time to exhaustion while swimming under load was recorded. After swimming, the serum lactate (LA) and creatine kinase (CK) levels (fatigue metabolic markers) were measured.

[0051] 2.3 The experimental results are shown in Table 2.

[0052] Table 2 Results of the experiment on improving sleep and relieving fatigue

[0053] As shown in Table 2, Examples 1-4 all contain the complete core components. Although there are differences in dosage, the effects of improving sleep and relieving fatigue are significant and similar, proving the stability of the synergistic effect of the core raw material components of the present invention.

[0054] In Example 1, GABA's core function is as a major inhibitory neurotransmitter in the central nervous system. Its core function is to bind to central GABA-A receptors, directly inhibiting nerve excitation transmission, thereby exerting a fundamental effect of sedation, sleep aid, and anxiety relief. It is the core functional carrier of the sedation-relaxation-synergistic-repair system. Turmeric extract reduces GABA metabolic inactivation by inhibiting intestinal glucuronyl transferase activity and optimizes its transmembrane absorption channels, increasing GABA intestinal absorption rate to 30%-40% (i.e., more than doubling bioavailability). In contrast, Comparative Example 1, lacking this synergistic carrier, experienced a significant reduction in effective GABA absorption, resulting in a marked weakening of the central sedative effect. Ultimately, this led to a 30% decrease in sleep onset efficiency, sleep depth, and fatigue relief compared to Example 1, directly demonstrating that GABA's core function relies on the synergistic effect of turmeric extract to be fully realized.

[0055] Comparative Example 3, lacking only passion fruit extract and lemon balm extract, showed a decrease in efficacy of approximately 50% compared to Example 1. The fundamental reason is that passion fruit extract and lemon balm extract, along with GABA and tea theanine, form a multi-target emotional regulation loop. Flavonoids in passion fruit extract (such as apigenin) can inhibit central serotonin reuptake, prolonging the mood-soothing effect. Rosemamate in lemon balm extract can regulate γ-aminobutyric acid transaminase activity, reducing GABA degradation and forming a dual effect of endogenous protection and exogenous supplementation with exogenous GABA. Tea theanine can promote the generation of alpha brain waves in a low-anxiety state, eliminating emotional interference barriers for GABA to exert its calming effect. These three components synergistically achieve a progressive effect of anxiety relief, sedation, sleep aid, and nerve relaxation. Without these herbal components, GABA and tea theanine alone cannot form a complete regulatory pathway, leading to a significant decrease in efficacy.

[0056] Comparative Example 2 only simplified the coating process, and the technical effect decreased by 40% compared with Example 1. The core reason is that the optimized process is as follows: After simplifying the T1 co-coating process, GABA and turmeric extract are directly exposed to the gastric acid environment, and the degradation rate of GABA increases by more than 40%. Curcumin is easily oxidized and inactivated due to lack of protection. The synergistic effect of simultaneous release and absorption of the two is destroyed, and the bioavailability is greatly reduced. Without the T2-T3 double coating, passion fruit extract and lemon balm extract are decomposed in the stomach and cannot reach the colon for targeted release, breaking the closed loop of the sedative-enhancing effect of GABA. The theanine in tea leaves was not treated for rapid release, and the rapid soothing effect of inducing alpha brain waves in 15-30 minutes disappeared, failing to pave the way for subsequent sleep aid. The dual value of turmeric extract in enhancing efficacy and repair was not fully utilized. It failed to effectively improve the absorption of the core components, and its anti-inflammatory and antioxidant effects were weakened due to component inactivation. Ultimately, the triple functions of sleep optimization, immediate soothing and fatigue repair were reduced to only basic functions, and the overall effect decreased by 40% compared with Example 1.

[0057] 3. Clinical trials: Sixty volunteers (aged 18-60, meeting the criteria for difficulty falling asleep (sleep onset time >30 minutes) and daytime fatigue (fatigue scale score ≥6 points) and signing informed consent forms) were recruited and randomly assigned to four groups: a blank control group (placebo), comparative group 1, comparative group 2, comparative group 3, example group 1, and example group 4, with 20 volunteers in each group. The experimental group took two tablets (1g each) daily, while the control group took a placebo with the same appearance, for 28 consecutive days. Sleep data was recorded using a sleep monitoring app, and subjective feelings were assessed using the Fatigue Scale (FS-14) and the Anxiety Scale (GAD-7). Serum serotonin (a mood regulation indicator) was also measured simultaneously. The results are shown in Table 3.

[0058] Table 3. Clinical test results of Comparative Examples 1-3 and the blank control group

[0059] Table 4. Clinical test results of Examples 1 and 4 and the blank control group

[0060] As shown in Tables 3 and 4, Examples 1 and 4 performed best among all indicators: sleep onset time was shortened to 12-13.5 min, nighttime awakenings were ≤0.9 times, FS-14 / GAD-7 scores decreased to 2.6-3.5 points, and serum serotonin increased to over 145.6 ng / mL, confirming the effectiveness of the synergistic closed loop of sedation, relaxation, and enhancement.

[0061] Comparative Example 1 showed a decrease of approximately 30% in serum serotonin and sleep onset efficiency compared to Example 1, demonstrating the core role of turmeric in enhancing GABA bioavailability. Comparative Example 3 showed similar GAD-7 scores and sleep onset time to the control group, indicating that the synergistic support of herbal components for mood regulation and sleep is irreplaceable. Comparative Example 2 showed intact raw materials, but a 40% decrease in sleep onset time and FS-14 score compared to Example 1, confirming that the T1-T4 pretreatment, through protecting components and targeted release, provided the necessary absorption efficiency and time window for synergistic effects of the raw materials.

[0062] 4. Typical Case: Case 1: Mr. Zhang, a 32-year-old programmer, had difficulty falling asleep for 6 months, with an average sleep latency of 45 minutes and a daytime fatigue score of 8. After taking the composition of Example 4 for 14 days, his sleep latency decreased to 15 minutes and his fatigue score dropped to 4. After 28 days, his sleep latency stabilized at 10 minutes, his fatigue score was 3, and his work concentration significantly improved.

[0063] Case 2: Mr. Li, a 55-year-old teacher, experienced frequent awakenings at night (3-4 times / night) and significant morning fatigue. His serum serotonin level was 82 ng / mL. After taking the composition of Example 4 for 21 days, the number of nighttime awakenings decreased to once, morning fatigue disappeared, serum serotonin rose to 148 ng / mL, and his self-rated sleep quality improved from 3 out of 10 to 8.

[0064] Case 3: Mr. Wang, a 42-year-old salesperson, had difficulty falling asleep (60 minutes+) due to work pressure. His FS-14 score was 9. After taking the composition of Comparative Example 2 for 28 days, his sleep onset time was shortened to 30 minutes and his score dropped to 6. After switching to the composition of Example 4 for 14 days, his sleep onset time was further shortened to 12 minutes and his score dropped to 3.

[0065] Therefore, this invention employs the above-mentioned composition for mood regulation and stress relief, its preparation method, and its application to construct a multi-target synergistic system of absorption enhancement, neuromodulation, and fatigue repair. While significantly improving the bioavailability of core components such as γ-aminobutyric acid, it also has anti-inflammatory and antioxidant functions, achieving a dual enhancement of sleep improvement and fatigue relief, thereby realizing the effects of mood regulation and stress relief.

[0066] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and not to limit them. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can still be made to the technical solutions of the present invention, and these modifications or equivalent substitutions cannot cause the modified technical solutions to deviate from the spirit and scope of the technical solutions of the present invention.

Claims

1. A composition for mood regulation and stress relief, characterized in that: By weight percentage, it includes the following ingredients: 15-20% γ-aminobutyric acid, 8-12% passionflower extract, 5-8% tea theanine, 2-4% lemon balm extract, 1-2% turmeric extract, 45-55% sorbitol, 10-12% microcrystalline cellulose, 0.8-1.2% magnesium stearate, 1-2% chamomile flavor, and 0.1-0.2% sucralose.

2. The method for preparing a mood-regulating and stress-relieving composition as described in claim 1, characterized in that: Includes the following steps: Step 1: Prepare GABA-turmeric synergistic granules by double-coating passionflower extract and lemon balm extract to obtain double-layer encapsulated microcapsules and by rapidly releasing theanine from tea leaves to obtain a rapid-release mixture. Step 2: Premix chamomile flavoring with a portion of sorbitol to obtain flavoring-sorbitol premixed powder, wherein the portion of sorbitol accounts for 5-10% of the total sorbitol content; Step 3: Add all of the GABA-turmeric synergistic granules, double-layer encapsulated microcapsules and immediate-release mixture, flavor-sorbitol premix powder, remaining sorbitol, remaining microcrystalline cellulose, sucralose and magnesium stearate into a three-dimensional mixer and mix to obtain the final mixture. Step 4: Feed the final mixture into a rotary tablet press for tableting. The tablets are then sealed in aluminum foil.

3. The method for preparing a composition for mood regulation and stress relief according to claim 2, characterized in that: The specific steps for step one are as follows: T1. GABA-turmeric synergistic granules were obtained by premixing γ-aminobutyric acid and turmeric extract, using fluidized bed bottom spray coating technology and maltodextrin solution with a solid content of 28-32% as coating material. T2. Passion fruit extract and lemon balm extract are premixed, and a compound aqueous solution of sodium alginate and chitosan is used as a coating material. The premixed passion fruit extract and lemon balm extract are coated once through a fluidized bed to form an enteric layer on the surface of the premixed passion fruit extract and lemon balm extract. T3. The premixed passion fruit extract and lemon balm extract that have undergone one coating in T2 are used in fluidized bed melt coating technology and hydrogenated vegetable oil is used for a second coating to form a flavor masking layer on the surface of the enteric layer, finally obtaining double-layer encapsulated herbal microcapsules. T4. Theanine from tea leaves and a portion of microcrystalline cellulose are added to a three-dimensional mixer for mixing, wherein the portion of microcrystalline cellulose accounts for 5% of the total amount of microcrystalline cellulose.

4. The method for preparing a composition for mood regulation and stress relief according to claim 3, characterized in that: In T1, the coating weight gain rate is 5-8%. The fluidized bed parameters are: inlet temperature 55-65℃, outlet temperature 35-45℃, atomization pressure 0.2-0.3MPa. After granulation, the product is passed through a 30-mesh sieve to obtain GABA-turmeric synergistic granules. The dry weight of maltodextrin in the maltodextrin solution is the total weight of γ-aminobutyric acid and turmeric extract × coating weight gain rate.

5. A method for preparing a composition for mood regulation and stress relief according to claim 3, characterized in that: In T2, the pH of the coating solution was 5.5-6, and the mixture was stirred for 30-40 minutes at a speed of 300-350 rpm. The weight gain of the enteric coating was 8-12%. The fluidized bed parameters were the same as those in T1. The amount of sodium alginate and chitosan compound aqueous solution used was the sum of passion fruit extract and lemon balm extract × the weight gain of the enteric coating.

6. A method for preparing a composition for mood regulation and stress relief according to claim 3, characterized in that: In T3, the weight gain of the masking layer coating is 3-5%, the melt coating temperature is 68-72℃, and the amount of hydrogenated vegetable oil used is the total weight of γ-aminobutyric acid, turmeric extract and the masking layer × the weight gain of the masking layer coating.

7. A method for preparing a mood-regulating and stress-relieving composition according to claim 3, characterized in that: In T4, the mixing speed is 15-20 rpm and the mixing time is 10-15 min.

8. A method for preparing a composition for mood regulation and stress relief according to claim 2, characterized in that: In step three, the rotation speed of the three-dimensional mixer is 15-20 rpm, and the mixing time is 20-25 min.

9. A method for preparing a composition for mood regulation and stress relief according to claim 2, characterized in that: In step four, the parameters for compression molding are: relative humidity ≤55%, temperature 20-30℃, tablet weight 1g / tablet, and hardness 40-50N.

10. The use of the mood-regulating and stress-relieving composition as described in claim 1 in the preparation of food products for mood regulation and stress relief.

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