Traditional Chinese medicine acupoint patch for clearing heat and improving eyesight for amblyopia rehabilitation and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine acupoint patch for clearing heat and improving eyesight for amblyopia rehabilitation and a preparation method of the traditional Chinese medicine acupoint patch, and particularly relates to the technical field of traditional Chinese medicine patches, the traditional Chinese medicine acupoint patch comprises a backing layer, and a medicine gel layer and a micro-capsule array layer which are sequentially stacked on the backing layer; the medicine gel layer is prepared from a mixture and a medical gel matrix, wherein the mixture comprises the following raw materials in parts by weight: 8-12 parts of butterflybush flower, 6-10 parts of feather cockscomb seed, 5-9 parts of fructus broussonetiae, 4-8 parts of motherwort fruit and 3-7 parts of pipewort. Through the composite structure of the drug gel layer and the acupoint targeting micro-capsule array layer, synergy of quick release and long-acting slow release of a drug is achieved, the defects that a traditional patch is single in release behavior and short in action time are overcome, and the micro-capsules are distributed according to the periorbital acupoints and are combined with the gradient design of density and particle size, so that the micro-capsules are more stable in effect. Accurate and differentiated stimulation on acupuncture points such as zanzhu, Jingming and fish waist is achieved, the pertinence and curative effect of acupuncture point treatment are improved, the micro-capsules are precisely positioned through the silk-screen printing technology, and it is guaranteed that the product performance is uniform and stable.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine patch technology, and more specifically, to a traditional Chinese medicine acupoint patch for amblyopia rehabilitation that clears heat and improves vision, and its preparation method. Background Technology

[0002] Amblyopia is a common eye disease during the visual development period of children. It is caused by insufficient visual stimulation of one or both eyes or abnormal interaction between the two eyes, resulting in a decrease in best corrected visual acuity without organic lesions. Its rehabilitation treatment is a long-term and systematic process. The key is to make effective interventions during the sensitive period of visual development. At present, the main clinical treatment methods include refractive correction, occlusion therapy, and visual training. Traditional Chinese medicine external application to acupoints around the eyes is a traditional external treatment method. Through the dual effects of transdermal drug absorption and acupoint stimulation, it can clear the liver and improve vision, dredge the meridians, and nourish the eye system, providing a unique treatment approach for the rehabilitation of amblyopia.

[0003] However, existing Chinese herbal eye patches or external patches are mostly single-layer gels or ointments, with a single drug release behavior, which cannot achieve the long-term and stable effect required for amblyopia rehabilitation. Secondly, the drugs are usually evenly dispersed and lack precise targeting to specific acupoints such as Zanzhu, Jingming, and Yuyao, making it difficult to take advantage of acupoint therapy. Finally, traditional processes make it difficult to accurately and stably position trace amounts of drugs in different acupoint areas, and are not convenient for large-scale production. Summary of the Invention

[0004] In order to overcome the above-mentioned defects of the prior art, the present invention provides a traditional Chinese medicine acupoint patch for amblyopia rehabilitation that clears heat and improves vision, and its preparation method, so as to solve the problems mentioned in the background art.

[0005] To achieve the above objectives, the present invention provides the following technical solution: a traditional Chinese medicine acupoint patch for amblyopia rehabilitation, comprising a backing layer, and a drug gel layer and a microcapsule array layer sequentially stacked on the backing layer; The drug gel layer is made of a mixture of the following raw materials in parts by weight and a medical gel matrix: 8-12 parts of Buddleja officinalis, 6-10 parts of Celosia argentea, 5-9 parts of Broussonetia papyrifera, 4-8 parts of Leonurus japonicus, and 3-7 parts of Eriocaulon buergerianum. The microcapsule array layer consists of multiple sustained-release microcapsules fixed to the surface of the drug gel layer, and the multiple sustained-release microcapsules are arranged according to a preset pattern that corresponds to the surface projection positions of the Zanzhu, Jingming, and Yuyao acupoints around the human eye; the wall material of the sustained-release microcapsules is a compound of chitosan and sodium alginate, and it contains active extracts of traditional Chinese medicine made from the following herbs: Buddleja officinalis, Celosia argentea, Broussonetia papyrifera, Leonurus japonicus, and Eriocaulon buergerianum.

[0006] Preferably, the sustained-release microcapsules have a particle size of 80-120 μm; the mass ratio of the wall material to the active extract of the traditional Chinese medicine is 1:2.5 to 1:3.5.

[0007] Preferably, in the microcapsule array layer, the sustained-release microcapsules corresponding to the surface projection area of ​​the Zanzhu acupoint have a first distribution density and a first average particle size, the sustained-release microcapsules corresponding to the surface projection area of ​​the Jingming acupoint have a second distribution density and a second average particle size, and the sustained-release microcapsules corresponding to the surface projection area of ​​the Yuyao acupoint have a third distribution density and a third average particle size. Furthermore, the first distribution density is greater than the second distribution density, and the second distribution density is greater than the third distribution density.

[0008] Preferably, the mixture of the drug gel layer further includes a penetration enhancer, which is a mixture of evening primrose oil and perilla leaf oil in a mass ratio of 1:0.8 to 1:1.2.

[0009] Preferably, the medical gel matrix comprises sodium carboxymethyl cellulose, glycerol, and sorbitol.

[0010] Preferably, the backing layer is made of medical breathable non-woven fabric, and its edges are provided with pressure-sensitive rubber rings.

[0011] A method for preparing the above-mentioned traditional Chinese medicine acupoint patch includes the following steps: S1. Preparation of active extract: After crushing the flowers of Buddleja officinalis, Celosia argentea, Broussonetia papyrifera, Leonurus japonicus and Eriocaulon buergerianum, add 10-15 times the amount of 70-80% ethanol solution and perform ultrasonic and microwave synergistic extraction. The extract is concentrated under reduced pressure to obtain the active extract of traditional Chinese medicine. S2. Preparation of sustained-release microcapsules: The compound of chitosan and sodium alginate is dissolved in water, and an extract accounting for 15-25% of the total amount of active extract of traditional Chinese medicine obtained in S1 is added. The mixture is then emulsified, homogenized under high pressure, and freeze-dried to obtain the sustained-release microcapsules. S3. Preparation of drug gel layer: Mix the remaining active extract of traditional Chinese medicine in S1 with the medical gel matrix to make a paste, and apply it to the intermediate carrier to form the drug gel layer. S4. Positioning and Array Forming: The sustained-release microcapsules obtained in S2 are positioned and fixed on the surface of the drug gel layer according to a pattern that matches the body surface projection positions of the Zanzhu, Jingming, and Yuyao acupoints, thereby forming the microcapsule array layer; then the backing layer is laminated and cut to obtain the final product.

[0012] Preferably, the conditions for ultrasonic and microwave synergistic extraction in S1 are: ultrasonic power 200-300W, microwave power 150-200W, extraction temperature 55-65℃, extraction twice, each time for 25-35 minutes.

[0013] Preferably, the pressure of the high-pressure homogenization in S2 is 80-120 MPa, and the cycle is repeated 2-4 times.

[0014] Preferably, in step S4, the sustained-release microcapsules are positioned in the preset array using screen printing technology.

[0015] The technical effects and advantages of this invention are as follows: The underlying drug gel layer provides an initial rapid release of the drug, achieving an immediate therapeutic effect. The surface microcapsule array layer serves as a drug reservoir, maintaining a long-term effective therapeutic concentration through the continuous release of the sustained-release microcapsules. The microcapsules are not randomly distributed but are arranged in a patterned manner according to the surface projection positions of the Zanzhu, Jingming, and Yuyao acupoints. This design, which combines rapid and sustained release and precisely corresponds to the theory of acupoints in traditional Chinese medicine, allows the drug energy to act on the target acupoints more concentratedly and for a longer period of time. This effectively overcomes the problems of drug dispersion, short duration of action, and inaccurate acupoint stimulation in traditional external patches, thus providing a more efficient and precise external treatment method for the rehabilitation of amblyopia. Through the composite structural design of the drug gel layer and the microcapsule array layer and the targeted acupoint arrangement, the spatiotemporal coordinated delivery and precise treatment of the drug are achieved. By optimizing the microcapsule array, the distribution density and average particle size of the microcapsules corresponding to different acupoints are differentiated. For example, considering the different skin thickness, sensitivity, and treatment needs of acupoints such as Zanzhu, Jingming, and Yuyao, a fine-tuning of the stimulation intensity of different acupoints can be achieved by setting a microcapsule distribution density and corresponding particle size gradient from high to low. This gradient design makes the effect stronger on acupoint areas with thicker skin or requiring stronger stimulation, while the effect is gentler on areas with thinner skin or requiring milder stimulation. This enhances the overall therapeutic effect while also improving the safety and comfort of use. Through the differentiated density and particle size design of microcapsules in different acupoint areas, gradient and personalized control of acupoint stimulation intensity is achieved. By using screen printing, microcapsules are precisely positioned and fixed onto the surface of the gel layer according to a pre-set acupoint pattern. This method is simple to operate, accurate in positioning, and has good repeatability. It can efficiently and stably achieve large-scale preparation of microcapsule arrays, ensuring that each patch can accurately reproduce the designed acupoint targeting characteristics. This industrially scalable precision manufacturing process not only guarantees the accuracy of drug delivery and the consistency of quality between batches, but also combines traditional Chinese medicine patch therapy with modern precision manufacturing technology. It overcomes the drawbacks of inaccurate positioning and uneven dosage in manual patch application, and has both excellent therapeutic effects and reliable industrial production quality. Attached Figure Description

[0016] Figure 1 This is a schematic diagram of the overall structure of the present invention.

[0017] Figure 2 This is a schematic diagram of the method flow structure of the present invention.

[0018] The attached figures are labeled as follows: 1, backing layer; 11, pressure-sensitive rubber ring; 2, drug gel layer; 3, microcapsule array layer; 31, sustained-release microcapsule. Detailed Implementation

[0019] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0020] 1. Raw materials and specifications Chinese medicinal herbs: Buddleja officinalis, Celosia argentea, Broussonetia papyrifera, Leonurus japonicus, and Eriocaulon buergerianum are all pulverized and passed through a 40-mesh sieve for later use.

[0021] Excipients and materials: Chitosan, degree of deacetylation ≥90%, viscosity 100-200 mPa·s; Sodium alginate, viscosity 300-500 mPa·s; Sodium carboxymethyl cellulose; Glycerin; Sorbitol; Evening primrose oil; Perilla leaf oil; 75% v / v ethanol; Medical breathable nonwoven fabric; Medical acrylic pressure-sensitive adhesive; Release film.

[0022] 2. Preparation process (1) Preparation of active extracts of traditional Chinese medicine Weigh out 100g of Buddleja officinalis, 80g of Celosia argentea, 70g of Broussonetia papyrifera, 60g of Leonurus japonicus, and 50g of Eriocaulon buergerianum, totaling 360g. Mix them thoroughly and add 12 times the volume of 4.32L of 75% ethanol solution. Extract using an ultrasonic-microwave synergistic extraction device, setting the ultrasonic power to 250W and the microwave power to 180W, controlling the extraction temperature at 60±2℃, extracting twice, 30 minutes each time. Combine the two extracts, filter, and concentrate the filtrate under reduced pressure at 55℃ and -0.08MPa to obtain a thick paste-like active herbal extract with a relative density of 1.10-1.15 at 60℃, weighing 108g, with a yield of approximately 30%. Store at 4℃ for later use.

[0023] (2) Preparation of sustained-release microcapsules Weigh 6g of chitosan and 4g of sodium alginate, dissolve them in 200mL of deionized water, and stir until completely dissolved to obtain the wall material solution. Take 30g of the active extract of traditional Chinese medicine obtained in step (1), which accounts for about 27.8% of the total extract, and add it to the wall material solution. Emulsify it for 5 minutes at 10,000 rpm in a high-speed shear disperser to form a pre-emulsion. Transfer the pre-emulsion to a high-pressure homogenizer and homogenize it three times at 100MPa. Quickly freeze the homogenized microcapsule emulsion and then dry it to constant weight in a freeze dryer to obtain about 38g of light yellow sustained-release microcapsule powder. The yield is about 95% based on solids. The average particle size of the microcapsules is (98.5±12.3)μm, the particle size distribution span is 1.2, and the mass ratio of wall material to drug core is about 1:3.

[0024] (3) Preparation of drug gel layer Take 78g of the remaining active herbal extract from step (1), add a penetration enhancer (9g evening primrose oil and 9g perilla leaf oil mixed in a 1:1 mass ratio), and mix thoroughly. Separately weigh 15g sodium carboxymethyl cellulose, 30g glycerin, and 10g sorbitol, and mix them as a medical gel matrix. Mix the extract containing the penetration enhancer with the gel matrix, grind and stir thoroughly to form a uniform paste with a certain viscosity. Use an automatic coating machine to coat the paste at (280±20) g / m 2 The coating is evenly applied to the release film, with a coating thickness of about 0.4 mm. It is then placed in a 40°C oven and dried for 10 minutes to form a drug gel layer with a certain cohesive force.

[0025] (4) Positioning and array forming a. Design and preparation of screen templates: Based on the standard surface projection positions of the Zanzhu, Jingming, and Yuyao acupoints around the eyes in adults, design corresponding microcapsule arrangement array patterns and make corresponding screen templates.

[0026] b. Printing and positioning: The sustained-release microcapsule powder obtained in step (2) is mixed with a small amount of light liquid paraffin to form a paste suitable for screen printing. Using the screen template prepared in step a, the microcapsule paste is accurately printed onto the surface of the drug gel layer prepared in step (3) through a precision screen printing machine. The printing pressure is controlled at 0.3-0.4 MPa.

[0027] c. Gradient settings: During the printing process, differentiated distribution of microcapsules is achieved by controlling the printing parameters in different areas. The microcapsule distribution density in the area corresponding to the Zanzhu acupoint was set to (20±2) cells / cm². 2 It mainly uses microcapsules with a particle size of 100-120μm.

[0028] The microcapsule distribution density in the area corresponding to the Jingming acupoint was set to (13±2) cells / cm².2 It mainly uses microcapsules with a particle size of 80-100μm.

[0029] The microcapsule distribution density in the area corresponding to the Yuyao acupoint was set to (9±2) cells / cm. 2 It mainly uses microcapsules with a particle size of 60-80μm.

[0030] After printing, the carrier is allowed to evaporate at room temperature for 15 minutes, and the microcapsules are then firmly fixed on the surface of the gel layer, forming a microcapsule array layer with acupoint-specific density and particle size gradient.

[0031] (5) Composite molding and cutting Around the drug gel layer with microcapsule array layer, a medical acrylic pressure-sensitive adhesive with a width of 3-5 mm and a thickness of about 0.05 mm is coated. A medical breathable non-woven fabric is then attached to the coated area as a backing layer. The composite material is placed in a constant temperature chamber at 45°C and a relative humidity of 50-60% for 20 hours to cure. Finally, the product is cut into an oval shape of the required size, such as 4cm × 2.5cm, using a die-cutting machine to obtain the finished traditional Chinese medicine acupoint patch of the present invention.

[0032] Examples 2-3: Preparation of acupoint patches under different parameters Following the basic process flow of Example 1, samples of Example 2 and Example 3 were prepared by adjusting only the key parameters in Table 1.

[0033] Key process parameters comparison table for Examples 1-3: Comparative Example 1: Ordinary Chinese herbal patches without microcapsule array layers Except for not performing the preparation of sustained-release microcapsules in step (2) and the array forming process in step (4), the rest of the formula and steps (1), (3), and (5) are exactly the same as in Example 1. That is, 108g of all active Chinese medicine extracts are mixed with the penetration enhancer and gel matrix and then directly coated, compounded, and cut to make a traditional Chinese medicine patch without microcapsule array layer.

[0034] Comparative Example 2: Microcapsule homogeneous mixture patch The sustained-release microcapsules were prepared according to the formulation and process of Example 1. However, in step (3) when preparing the drug gel layer, 38g of the prepared sustained-release microcapsule powder was mixed evenly with the remaining extract, permeation enhancer and gel matrix, and then coated and shaped. The subsequent steps were the same, that is, the microcapsules were evenly dispersed inside the gel layer, rather than fixed on the surface in an array.

[0035] In vitro release assay Using 900 mL of phosphate buffer solution at pH 7.4 as the release medium, the rotation speed was 50 rpm, and the temperature was (37.0±0.5) ℃. Patch samples from Examples 1-3 and Comparative Examples 1 and 2 were taken and cut into pieces containing approximately 1 g of raw medicinal material. They were fixed in a stainless steel mesh basket with the gel surface facing the release medium. 5 mL samples were taken at specified time points of 0.5, 1, 2, 4, 6, 8, 12, 24, and 48 h. At the same time, an equal volume of fresh medium was added at the same temperature. The samples were filtered through a 0.45 μm microporous membrane. The concentration of characteristic components in the filtrate, expressed as total amounts of styracidin and celosia oleracea glycoside A, was determined by high performance liquid chromatography (HPLC). The cumulative release rate (Q%) was calculated.

[0036] Comparison of in vitro cumulative release rates (Q%) of different samples: Conclusion: The data above show that Examples 1-3 all exhibited obvious sustained-release characteristics, with the drug continuously released within 48 hours. In contrast, Comparative Example 1, without microcapsules, released almost all of the drug within 24 hours, belonging to the immediate-release type. Although the uniform mixing of microcapsules in Comparative Example 2 had a certain sustained-release effect, its release rate at 2 hours and 8 hours was still higher than that of Example 1. This indicates that the structural design of the "surface array layer and bottom gel layer" of the present invention has certain advantages in controlling drug release behavior and achieving a more stable sustained release.

[0037] Skin irritation test Healthy New Zealand rabbits were selected for primary skin irritation tests. Hair was removed from both sides of the spine on the back of the rabbits, and four areas were selected on each side. Samples from Example 1, Comparative Example 1, a blank substrate without drugs, and saline-moistened gauze as a negative control were applied to these areas respectively. The test substances were removed after 24 hours, and the erythema and edema of the skin were observed and recorded at 1, 24, 48, and 72 hours after the removal of the test substances, and were scored.

[0038] Results: In Example 1, Comparative Example 1, and the blank matrix patch group, no erythema or edema was observed on the rabbit skin at any of the observation time points, and the reaction scores were all 0, indicating that the acupoint patch and its raw materials of the present invention are non-irritating to the skin and have good safety.

[0039] Preliminary pharmacodynamic observations All animal experiments in this study followed national regulations on the management and use of laboratory animals and were conducted in laboratory animal facilities that met ethical requirements.

[0040] A rat model of monocular visual deprivation amblyopia was established using the classic monocular eyelid suturing method. The successfully modeled rats were randomly divided into a model control group, a comparative example group 1, a comparative example group 2, and an example group 1, with 10 rats in each group. Starting from the 7th day after modeling, corresponding patches were applied to the corresponding acupoints around the eyes for 6 hours every day for 4 consecutive weeks. After the intervention, the latency of the P1 wave was detected by flash visual evoked potential.

[0041] Results: Compared with the model control group, the latency of P1 waves in each intervention group was shortened to varying degrees. Among them, the shortening of the P1 wave latency in Example 1 group was greater than that in Comparative Example 1 and Comparative Example 2 groups. This indicates that the patch with acupoint-targeting microcapsule array structure provided by the present invention shows a potential trend of being superior to traditional patches and uniformly mixed patches in promoting the recovery of visual function in amblyopia model animals.

[0042] As can be seen from the above embodiments and experimental examples, the traditional Chinese medicine acupoint patch and its preparation method provided by the present invention, through the unique structure of the drug gel layer and the surface acupoint targeted microcapsule array layer, combined with the gradient microcapsule design of different acupoints, realizes the combination of rapid release and sustained release of drugs, and the release behavior is more controllable and longer-lasting. In vitro release experiments and preliminary animal efficacy observations both indicate that the patch of the present invention shows a trend of being superior to the control patch without microcapsules or with uniformly distributed microcapsules in terms of sustained-release performance and promotion of visual function recovery.

[0043] Skin irritation tests have verified that this product is non-irritating to the skin and is suitable for long-term application.

[0044] The ultrasonic-microwave extraction, high-pressure homogenization, and screen printing positioning processes used are all mature technologies with clear parameters, which are conducive to industrial production and quality control.

[0045] Finally, it should be noted that the accompanying drawings of the embodiments disclosed in this invention only involve the structures involved in the embodiments disclosed in this invention. Other structures can refer to the general design. In the absence of conflict, the same embodiment and different embodiments of this invention can be combined with each other. In conclusion, the above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A traditional Chinese medicine acupoint patch for amblyopia rehabilitation, characterized by: It includes a backing layer (1), and a drug gel layer (2) and a microcapsule array layer (3) sequentially stacked on the backing layer (1). The drug gel layer (2) is made of a mixture of the following raw materials in parts by weight and a medical gel matrix: 8-12 parts of Buddleja officinalis, 6-10 parts of Celosia argentea, 5-9 parts of Broussonetia papyrifera, 4-8 parts of Leonurus japonicus, and 3-7 parts of Eriocaulon buergerianum. The microcapsule array layer (3) is composed of multiple sustained-release microcapsules (31) fixed on the surface of the drug gel layer (2), and the multiple sustained-release microcapsules (31) are arranged according to a preset pattern that corresponds to the surface projection position of the Zanzhu, Jingming and Yuyao acupoints around the human eye; the wall material of the sustained-release microcapsule (31) is a compound of chitosan and sodium alginate, and it contains active extracts of traditional Chinese medicine made from the above-mentioned Buddleja officinalis, Celosia argentea, Broussonetia papyrifera, Leonurus japonicus and Eriocaulon buergerianum.

2. The traditional Chinese medicine acupoint patch for amblyopia rehabilitation with heat-clearing and vision-improving properties according to claim 1, characterized in that: The sustained-release microcapsules (31) have a particle size of 80-120 μm; the mass ratio of the wall material to the active extract of the traditional Chinese medicine is 1:2.5 to 1:3.

5.

3. The traditional Chinese medicine acupoint patch for amblyopia rehabilitation with heat-clearing and vision-improving properties according to claim 1, characterized in that: In the microcapsule array layer (3), the sustained-release microcapsules (31) corresponding to the surface projection area of ​​the Zanzhu acupoint have a first distribution density and a first average particle size, the sustained-release microcapsules (31) corresponding to the surface projection area of ​​the Jingming acupoint have a second distribution density and a second average particle size, and the sustained-release microcapsules (31) corresponding to the surface projection area of ​​the Yuyao acupoint have a third distribution density and a third average particle size. Furthermore, the first distribution density is greater than the second distribution density, and the second distribution density is greater than the third distribution density.

4. The traditional Chinese medicine acupoint patch for amblyopia rehabilitation with heat-clearing and vision-improving properties according to claim 1, characterized in that: The mixture of the drug gel layer (2) also includes a penetration enhancer, which is a mixture of evening primrose oil and perilla leaf oil in a mass ratio of 1:0.8 to 1:1.

2.

5. The traditional Chinese medicine acupoint patch for amblyopia rehabilitation with heat-clearing and vision-improving properties according to claim 1, characterized in that: The medical gel matrix includes sodium carboxymethyl cellulose, glycerol, and sorbitol.

6. The traditional Chinese medicine acupoint patch for amblyopia rehabilitation with heat-clearing and vision-improving properties according to claim 1, characterized in that: The backing layer (1) is made of medical breathable non-woven fabric, and its edge is provided with pressure-sensitive rubber rings (11).

7. A method for preparing a traditional Chinese medicine acupoint patch as described in any one of claims 1-6, characterized in that: Includes the following steps: S1. Preparation of active extract: After crushing the flowers of Buddleja officinalis, Celosia argentea, Broussonetia papyrifera, Leonurus japonicus and Eriocaulon buergerianum, add 10-15 times the amount of 70-80% ethanol solution and perform ultrasonic and microwave synergistic extraction. The extract is concentrated under reduced pressure to obtain the active extract of traditional Chinese medicine. S2. Preparation of sustained-release microcapsules: The compound of chitosan and sodium alginate is dissolved in water, and an extract accounting for 15-25% of the total amount of active extract of traditional Chinese medicine obtained in S1 is added. After emulsification, high pressure homogenization and freeze drying, the sustained-release microcapsules (31) are obtained. S3, Preparation of drug gel layer: Mix the remaining active extract of traditional Chinese medicine in S1 with medical gel matrix to make a paste, and apply it to the intermediate carrier to form the drug gel layer (2). S4. Positioning and array forming: The sustained-release microcapsules (31) obtained in S2 are positioned and fixed on the surface of the drug gel layer (2) according to the pattern that matches the projection position of the Zanzhu, Jingming and Yuyao acupoints on the body surface, thereby forming the microcapsule array layer (3); then the backing layer (1) is laminated and cut to obtain the final product.

8. The preparation method according to claim 7, characterized in that: The conditions for ultrasonic and microwave synergistic extraction in S1 are as follows: ultrasonic power 200-300W, microwave power 150-200W, extraction temperature 55-65℃, extraction twice, each time for 25-35 minutes.

9. The preparation method according to claim 7, characterized in that: The pressure of the high-pressure homogenization in S2 is 80-120 MPa, and the cycle is 2-4 times.

10. The preparation method according to claim 7, characterized in that: In step S4, the sustained-release microcapsules (31) are positioned in the preset array using screen printing technology.

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