Targeted drug sustained-release device for fundus trauma

Abstract

The invention relates to a fundus trauma targeted drug sustained-release device which comprises an injection shell and a sustained-release shell, clamping plates are fixed to the two sides of the injection shell, a plurality of cavities are formed in one end of the injection shell, push rods extend into the cavities, the ends, located in the cavities, of the push rods are connected with pistons, and movable plate bodies are fixed to the ends, extending out of the cavities, of the push rods; a bidirectional driving assembly is arranged at the other end of the injection shell and used for synchronously carrying out pushing injection and stirring, so that the medicine and the carrier are continuously mixed in the flowing state, and synchronous mixing, precise pushing injection and automatic sealing of the medicine and the slow-release carrier are achieved through the action of the injection shell, the slow-release shell and the bidirectional driving assembly; the device is easy and convenient to operate and high in sealing performance, the problems of burst release and pollution of medicine can be effectively solved, and the slow release efficiency and safety in fundus trauma treatment are improved.

Description

Technical Field

[0001] This invention relates to the field of drug sustained-release devices, specifically a drug sustained-release device for targeting retinal trauma. Background Technology

[0002] For sustained-release drug therapy for retinal trauma, the drug is usually injected by pre-mixing the drug with a sustained-release carrier. Such devices are mostly composed of multi-cavity structures and conventional injection components. After the drug and sustained-release carrier (such as microspheres or hydrogel precursors) are mixed in an external device, they are injected into the retinal area through an injection needle to achieve a continuous drug delivery effect.

[0003] According to published patent CN107073203B, a drug sustained-release system is disclosed, comprising: an apparatus for preparing a drug sustained-release system, the apparatus including a drug carrier in a gel or solid phase under closed conditions; a mixing space configured to allow a drug for forming a drug sustained-release system with the drug carrier to be injected from the outside and mixed with the drug carrier; and a syringe for injecting the drug into the apparatus for preparing the drug sustained-release system. The patent also provides an apparatus for preparing a drug sustained-release system that can be used with the apparatus, and a method for preparing a drug sustained-release system using the apparatus. The drug sustained-release system can be easily prepared on-site, allowing the drug to be released sustainably in vivo.

[0004] However, existing technologies have the following shortcomings: pre-mixing the drug and sustained-release carrier with a stirrer can easily lead to carrier degradation, drug burst release, or changes in material compatibility, making it difficult to ensure sustained drug release; traditional injection systems lack simultaneous injection and stirring functions, making it easy for the drug and carrier to undergo chromatographic separation during injection, resulting in unstable sustained-release performance; and they lack automatic sealing and anti-contamination structures, requiring manual sealing before and after injection, which is complex and detrimental to maintaining a sterile environment. Therefore, we propose a targeted drug sustained-release device for retinal trauma. Summary of the Invention

[0005] The purpose of this invention is to overcome the shortcomings of the prior art, adapt to practical needs, and provide a sustained-release device for targeted drugs for fundus trauma. This device addresses the following technical problems: pre-mixing of drugs and sustained-release carriers can easily lead to carrier degradation, drug burst release, or changes in material compatibility, making it difficult to ensure the continuous release of drug efficacy; traditional injection systems lack simultaneous injection and stirring functions, making it easy for drugs and carriers to undergo chromatographic separation during injection, resulting in unstable sustained-release performance; and the lack of automatic sealing and anti-contamination structures requires manual sealing before and after injection, making operation complex and unfavorable for maintaining a sterile environment.

[0006] To achieve the objectives of this invention, the technical solution adopted is as follows: a sustained-release device for targeted drug delivery in retinal trauma is designed, comprising an injection shell and a sustained-release shell. A retaining plate is fixed to both sides of the injection shell. Multiple chambers are opened at one end of the injection shell, and push rods extend into each of the chambers. A piston is connected to one end of the push rod within a chamber, and a movable plate is fixed to the other end of the push rod extending out of the chamber. A bidirectional drive assembly is provided at the other end of the injection shell for simultaneous injection and agitation, allowing the drug and carrier to be continuously mixed directly in a flowing state.

[0007] In practical applications, the injection and agitation can be carried out simultaneously under the drive of the bidirectional drive component, so that the drug and carrier are continuously mixed in a flowing state, thereby ensuring the uniformity of mixing, avoiding the complicated procedures of traditional external premixing systems, and simplifying the operation process.

[0008] Preferably, the plurality of chambers are drug chambers and sustained-release carrier chambers, each containing a drug and a sustained-release carrier, for the purpose of mixing the drug and the sustained-release carrier directly inside the sustained-release shell.

[0009] In practical applications, when the dual-axis motor is working, it drives the rotating rod and stirring blades to stir the drug and carrier mixture. On the other hand, it pushes the moving plate and push rod forward through the screw drive, thereby pushing the drug and carrier into the sustained-release shell for mixing and injection. This allows the drug and carrier to achieve dynamic homogeneous mixing in a flowing state, improving the dispersion uniformity of the sustained-release material and the controllability of drug release.

[0010] Preferably, the bidirectional drive assembly includes a dual-axis motor, with a rotating rod connected to the output shaft at one end of the dual-axis motor. The rotating rod extends into the slow-release housing, and multiple agitating blades are installed on the outside of the end of the rotating rod located inside the slow-release housing.

[0011] Preferably, the output shaft at the other end of the dual-axis motor is connected to a first threaded rod. The end of the first threaded rod away from the dual-axis motor passes through the injection housing and the movable plate to fix the limiting plate, and the threaded rod is threadedly connected to the threaded hole in the movable plate.

[0012] Preferably, one end of the movable plate is fixed with multiple limiting plates, which are inserted into the limiting grooves corresponding to those opened in the injection shell to limit the movement of the movable plate.

[0013] In practical applications, the limiting structure can prevent the moving plate from deviating and control its stroke range, ensuring stable push rod movement and accurate injection. Through the cooperation of the limiting plate and the limiting groove, it can effectively prevent over-push or disengagement, and improve the service life of the device and the injection accuracy.

[0014] Preferably, the push rod is made of transparent PVC and has a circular groove at its end, inside which an ultraviolet disinfection lamp is installed.

[0015] In practical applications, the internal channels of the chamber can be disinfected by irradiation before use, achieving aseptic treatment of the drug flow path, avoiding microbial contamination, and improving the safety and hygiene of the device.

[0016] Preferably, each of the four corners of one end of the slow-release shell is fixed with a limiting rod, and the end of the limiting rod is provided with a threaded groove. One end of a second threaded rod is threadedly connected inside the threaded groove, and the other end of the second threaded rod is fixed with a magnetic column.

[0017] In practical applications, the magnetic column and the magnetic block in the limiting hole of the injection shell attract each other, realizing the rapid positioning and connection of the two shells. The magnetic attraction structure can not only ensure the stable connection between the shells, but also facilitate the disassembly and maintenance of the device.

[0018] Preferably, the limiting rod, the second threaded rod, and the magnetic column extend into the limiting holes at the four corners of one end of the injection housing and are magnetically connected to the magnetic blocks installed in the limiting holes.

[0019] Preferably, one end of the slow-release housing is connected to a miniature delivery pump, and a needle is installed at the outlet end of the miniature delivery pump.

[0020] In practical applications, the needle is used to precisely inject the mixed drug sustained-release solution into the fundus of the eye. Through the precise control of the micro-pump, the injection volume and rate can be adjusted, thereby improving the effectiveness and safety of targeted therapy.

[0021] Preferably, a discharge tube head is installed on both sides of the other end of the injection shell. Multiple installation grooves are opened on the surface of the discharge tube head. Telescopic components are installed inside the multiple installation grooves. A sealing cap is fixed to one end of the telescopic component that extends out of the installation groove.

[0022] In practical applications, when the piston moves, the thrust overcomes the spring force to open the sealing cap, allowing the drug and carrier to flow out. After the injection is completed, the spring automatically resets, causing the sealing cap to close the channel, achieving automatic sealing to prevent leakage. This keeps the device sealed when not in operation, preventing drug leakage and air entry, and ensuring drug stability and system sterility.

[0023] Preferably, the telescopic component includes a fixed cylinder and a movable rod that are nested together. One end of the movable rod, located inside the fixed cylinder, is fixed with a spring, which is used to use the spring force to move the sealing cover to seal.

[0024] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0025] 1. This invention combines an injection shell, a chamber, and a sustained-release shell. The injection shell contains a drug chamber and a sustained-release carrier chamber, respectively. When the drug and sustained-release carrier in the drug chamber and sustained-release carrier chamber are introduced into the sustained-release shell, a dual-axis motor drives a rotating rod and multiple stirring blades to rotate. This allows for direct mixing and sustained-release of the drug, eliminating the need for pre-treatment equipment. It also avoids the problems in traditional pre-mixing systems where premature contact between the drug and the sustained-release carrier (such as microspheres or hydrogel precursors) leads to carrier degradation, drug burst release, or changes in material compatibility.

[0026] 2. This invention combines a dual-axis motor, a rotating rod, and a first threaded rod. During the driving of the dual-axis motor, not only can the rotating rod and multiple stirring blades be rotated by the dual-axis motor, and the multiple stirring blades be used to mix the drug and sustained-release carrier in the sustained-release shell, but the dual-axis motor also drives the first threaded rod to rotate, thereby moving the moving plate, push rod, and piston. This synchronously pushes the drug and sustained-release carrier in the drug chamber and sustained-release chamber into the sustained-release shell for mixing. Because the injection and stirring are carried out simultaneously, the drug and carrier are continuously mixed in a flowing state, ensuring a more uniform particle size distribution of the sustained-release microspheres or drug.

[0027] 3. This invention, through the combination of the discharge pipe head, telescopic component, and sealing cap, utilizes the elastic force of the spring inside the fixed cylinder to drive the moving rod and sealing cap to move, so that the sealing cap tightly adheres to the discharge pipe head, thereby sealing the drug and sustained-release carrier in the drug chamber and sustained-release chamber. When the piston moves, it pushes the sustained-release carrier in the drug chamber and sustained-release chamber to move, thereby pushing the sealing cap to move, allowing the drug and sustained-release carrier to enter the sustained-release shell for mixing, thus achieving automatic sealing of the drug and sustained-release carrier.

[0028] In summary, this invention achieves synchronous mixing, precise injection, and automatic sealing of drugs and sustained-release carriers through the functions of the injection shell, sustained-release shell, and bidirectional drive assembly. This invention is easy to operate, has strong sealing performance, and can effectively avoid drug burst release and contamination problems, thereby improving the sustained-release efficiency and safety in the treatment of fundus trauma. Attached Figure Description

[0029] Figure 1 This is a schematic diagram of the bidirectional drive component of the present invention;

[0030] Figure 2 This is a schematic diagram of the magnetic column structure of the present invention;

[0031] Figure 3 This is a schematic diagram of the overall structure of the present invention;

[0032] Figure 4 This is a schematic diagram of the telescopic component structure of the present invention;

[0033] Figure 5 This is a schematic diagram of the ultraviolet disinfection lamp tube of the present invention.

[0034] In the diagram: 1. Injection housing; 101. Moving plate; 102. Clamping plate; 2. Slow-release housing; 201. Miniature delivery pump; 202. Needle; 203. Dual-axis motor; 204. Rotating rod; 205. Agitating blade; 206. First threaded rod; 207. Push rod; 208. Limiting plate; 209. Limiting plate; 210. Limiting rod; 211. Limiting groove; 212. Piston; 213. Circular groove; 214. Ultraviolet disinfection lamp; 3. Magnetic column; 301. Limiting hole; 302. Second threaded rod; 303. Threaded groove; 4. Discharge pipe head; 401. Sealing cap; 402. Mounting groove; 403. Moving rod; 404. Spring; 405. Fixed cylinder. Detailed Implementation

[0035] The present invention will be further described below with reference to the accompanying drawings and embodiments:

[0036] Example 1: A targeted drug delivery device for retinal trauma, see [link to example]. Figures 1 to 5 The device includes an injection housing 1 and a sustained-release housing 2. Both sides of the injection housing 1 are fixed with a retaining plate 102. One end of the injection housing 1 has multiple chambers, and each chamber has a push rod 207 extending into it. One end of the push rod 207 located in the chamber is connected to a piston 212. One end of the push rod 207 extending out of the chamber is fixed with a movable plate 101. The other end of the injection housing 1 is provided with a bidirectional drive assembly for simultaneous injection and agitation, so that the drug and carrier are continuously mixed in a flowing state.

[0037] The device mainly consists of an injection shell 1, a sustained-release shell 2, and a bidirectional drive assembly. The dual-axis motor 203 outputs two power sources. One end drives the rotating rod 204 and its end stirring blade 205 to rotate inside the sustained-release shell 2, which fully stirs the drug and carrier. The other end, through the threaded engagement of the first threaded rod 206 with the moving plate 101, pushes the push rod 207 and piston 212 forward, realizing the synchronous injection of the drug and carrier.

[0038] For details, see Figure 2 The multiple chambers are drug chambers and sustained-release carrier chambers, which are respectively filled with drugs and sustained-release carriers, so that the drugs and sustained-release carriers can be directly mixed inside the sustained-release shell 2.

[0039] Multiple chambers serve as drug chambers and sustained-release carrier chambers, respectively. The drug and carrier are stored independently before injection to avoid degradation and loss of efficacy caused by premature mixing. When the bidirectional drive component is activated, the push rod 207 drives the piston 212 to simultaneously send the contents of the two chambers into the sustained-release shell 2, and continuous mixing is achieved under the action of the stirring blade 205.

[0040] For more details, see Figure 1 The bidirectional drive assembly includes a dual-axis motor 203. The output shaft of one end of the dual-axis motor 203 is connected to a rotating rod 204. The rotating rod 204 extends into the slow-release housing 2, and multiple stirring blades 205 are installed on the outside of the end of the rotating rod 2 located inside the slow-release housing 2.

[0041] Further, see Figure 1 The output shaft of the other end of the dual-axis motor 203 is connected to a first threaded rod 206. The end of the first threaded rod 206 away from the dual-axis motor 203 passes through the injection housing 1 and the movable plate 101 and is fixed with a limiting plate 208. The threaded rod is threadedly connected to the threaded hole in the movable plate 101. A plurality of limiting plates 209 are fixed at one end of the movable plate 101. The plurality of limiting plates 209 are inserted into the corresponding limiting grooves 211 opened in the injection housing 1 to limit the movement of the movable plate 101.

[0042] To ensure injection accuracy, a limiting structure is provided between the moving plate 101 and the injection housing 1. The limiting groove 211 and the limiting plate 209 cooperate with each other to control the stroke of the push rod 207 and prevent over-push or deviation.

[0043] Further, see Figure 5 The push rod 207 is made of transparent PVC material and has a round groove 213 at the end. An ultraviolet disinfection lamp 214 is installed inside, which can irradiate and disinfect the channel before operation to maintain a sterile environment.

[0044] It is worth noting that, see Figure 2 The four corners of one end of the slow-release shell 2 are fixed with limiting rods 210. The end of the limiting rod 210 is provided with a threaded groove 303. The threaded groove 303 is threadedly connected to one end of the second threaded rod 302. The other end of the second threaded rod 302 is fixed with a magnetic column 3.

[0045] It is worth noting that, see Figure 2 The limiting rod 210, the second threaded rod 302 and the magnetic column 3 extend into the limiting holes 301 at the four corners of one end of the injection housing 1 and are magnetically connected to the magnetic blocks installed in the limiting holes 301.

[0046] It is worth mentioning that, see Figure 3 One end of the slow-release housing 2 is connected to a micro-pump 201, and a needle 202 is installed at the outlet end of the micro-pump 201.

[0047] It is worth noting that, see Figure 4The other two sides of the injection housing 1 are equipped with discharge pipe heads 4. Multiple installation grooves 402 are opened on the surface of the discharge pipe head 4. Telescopic components are installed inside the multiple installation grooves 402. A sealing cap 401 is fixed to one end of the telescopic component that extends out of the installation groove 402.

[0048] It is worth emphasizing that, see Figure 4 The telescopic component includes a fixed cylinder 405 and a movable rod 403 that are nested together. One end of the movable rod 403 located inside the fixed cylinder 405 is fixed with a spring 404, which is used to use the elastic force of the spring 404 to drive the movable rod 403 to move and seal the sealing cover 401.

[0049] When using a targeted drug release device for retinal trauma, the operator first aligns the injection housing 1 with the release housing 2. The release housing 2 is then magnetically connected to the magnetic block in the limiting hole 301 of the injection housing 1 via the limiting rods 210 at the four corners, the second threaded rod 302, and the magnetic column 3. The magnetic connection automatically positions and attracts the two housings, forming a sealed cavity. Before injection, the ultraviolet disinfection lamp 214 at the end of the push rod 207 is activated to irradiate and sterilize the drug chamber, the release carrier chamber, and the fluid channel inside the injection housing 1. This effectively kills microorganisms in the channel, achieving a sterile environment during the injection process. After disinfection, the lamp is turned off, and the drug is loaded. The drug solution to be injected is added to the drug chamber, and the release carrier (such as hydrogel precursor, microsphere suspension, etc.) is added to the release carrier chamber. Each chamber is independently sealed to prevent the drug and carrier from contacting each other prematurely during the loading stage. The sealing cap 401 at the discharge end is pressed tightly against the discharge tube head 4 under the action of the spring 404, achieving automatic sealing.

[0050] After the dual-axis motor 203 is started, the output shafts at both ends of the motor work simultaneously. One end drives the first threaded rod 206 to rotate, which, through its threaded engagement with the moving plate 101, pushes the moving plate 101, push rod 207, and piston 212 along the cavity direction. The other end drives the rotating rod 204 and its end-end stirring blade 205 to rotate at high speed inside the sustained-release housing 2, generating a vortex flow field. When the piston 212 is pushed, the media in the drug chamber and the sustained-release carrier chamber are simultaneously pushed out and flow into the interior of the sustained-release housing 2 through independent channels. The rotation of the stirring blade 205 creates forced convection, allowing the drug and carrier to be fully mixed in a flowing state. Because the injection and stirring are carried out simultaneously, the drug and carrier maintain a dynamic homogeneous state during the mixing process, thereby avoiding the problems of local uneven concentration or phase separation that occur in traditional processes. The mixed liquid is continuously sheared and stirred by the blades in the sustained-release shell 2 to form a sustained-release mixture with uniform particle size distribution. The stirring intensity and the screw propulsion speed can be adjusted according to the characteristics of the drug. When the mixture reaches the set homogeneity, the micro delivery pump 201 at one end of the sustained-release shell 2 is turned on. The pump injects the mixture quantitatively into the target position of the fundus through the needle 202. The flow control of the delivery pump can be adjusted to adjust the drug delivery rate as needed to achieve continuous and controllable drug release.

[0051] When the injection volume reaches the preset value, the dual-axis motor 203 and the micro-pump 201 are turned off, causing the threaded rod to stop rotating. The push rod 207 and piston 212 stop moving forward. Due to the release of internal pressure, the discharge end spring 404 drives the sealing cover 401 to automatically return to its original position, tightly sealing the discharge port to prevent leakage of residual medicine or backflow of air. After the magnetic connection is released, the slow-release housing 2 and the injection housing 1 can be quickly separated. The operator can clean the internal channel or replace the medicine to enable the device to be reused or maintained. After cleaning, the housing is reassembled and a functional test is performed to ensure that the limiting groove 211, push rod 207, stirring blade 205 and other structures are reset normally, preparing for the next use.

[0052] It should be noted that the ultraviolet lamp can be turned on before or after use to ensure that each injection is performed under sterile conditions. This is suitable for treatment scenarios with high cleanliness requirements, such as retinal trauma. The dual-axis motor 203 and the micro pump are both connected to an external industrial control computer for rate adjustment, enabling control of drug concentration and flow rate to meet the treatment needs of different patients.

[0053] Through the above process, the problems of drug burst release, degradation and incomplete sealing caused by traditional premixed systems are avoided, and precise, safe and long-lasting local sustained-release drug delivery to the fundus is achieved.

[0054] In addition, all components designed in this invention are general standard parts or components known to those skilled in the art. Their structure and principle can be known to those skilled in the art through technical manuals or conventional experimental methods. Those skilled in the art can fully implement them, so there is no need to elaborate. The content protected by this invention does not involve improvements to the internal structure and method.

Claims

1. A targeted drug release device for fundus trauma, comprising an injection housing (1) and a release housing (2), wherein both sides of the injection housing (1) are fixed with clamping plates (102), characterized in that, The injection housing (1) has multiple chambers at one end, and push rods (207) extend into each of the chambers. A piston (212) is connected to one end of the push rod (207) located in the chamber, and a movable plate (101) is fixed to one end of the push rod (207) extending out of the chamber. The other end of the injection housing (1) is provided with a bidirectional drive assembly for simultaneous injection and agitation, so that the drug and carrier are continuously mixed in a flowing state.

2. The targeted drug delivery device for fundus trauma as described in claim 1, characterized in that, The multiple chambers are drug chambers and sustained-release carrier chambers, which are respectively filled with drugs and sustained-release carriers, so as to allow the drugs and sustained-release carriers to be directly mixed inside the sustained-release shell (2).

3. The targeted drug delivery device for fundus trauma as described in claim 1, characterized in that, The bidirectional drive assembly includes a dual-axis motor (203), with a rotating rod (204) connected to the output shaft of one end of the dual-axis motor (203). The rotating rod (204) extends into the slow-release housing (2), and multiple stirring blades (205) are installed on the outside of the end of the rotating rod (2) located inside the slow-release housing (2).

4. The targeted drug delivery device for fundus trauma as described in claim 3, characterized in that, The output shaft at the other end of the dual-axis motor (203) is connected to a first threaded rod (206). The end of the first threaded rod (206) away from the dual-axis motor (203) passes through the injection housing (1) and the moving plate (101) to fix a limiting plate (208). The threaded rod is threadedly connected to the threaded hole in the moving plate (101). A plurality of limiting plates (209) are fixed at one end of the moving plate (101). The plurality of limiting plates (209) are inserted into the limiting grooves (211) corresponding to the injection housing (1) to limit the movement of the moving plate (101).

5. The targeted drug delivery device for fundus trauma as described in claim 1, characterized in that, The push rod (207) is made of transparent PVC and has a circular groove (213) at its end. An ultraviolet disinfection lamp (214) is installed inside the circular groove (213).

6. The targeted drug delivery device for fundus trauma as described in claim 1, characterized in that, The slow-release shell (2) has four corners fixed with limiting rods (210). The end of the limiting rod (210) is provided with a threaded groove (303). The threaded groove (303) is threaded to one end of a second threaded rod (302). The other end of the second threaded rod (302) is fixed with a magnetic column (3).

7. The targeted drug delivery device for fundus trauma as described in claim 6, characterized in that, The limiting rod (210), the second threaded rod (302) and the magnetic column (3) extend into the limiting holes (301) at the four corners of one end of the injection housing (1) and are magnetically connected to the magnetic blocks installed in the limiting holes (301).

8. The targeted drug delivery device for fundus trauma as described in claim 1, characterized in that, One end of the slow-release housing (2) is connected to a micro-pump (201), and a needle (202) is installed at the outlet end of the micro-pump (201).

9. The targeted drug delivery device for fundus trauma as described in claim 1, characterized in that, The injection housing (1) is equipped with discharge pipe heads (4) on both sides of the other end. Multiple installation grooves (402) are opened on the surface of the discharge pipe head (4). Telescopic components are installed inside the multiple installation grooves (402). A sealing cap (401) is fixed at one end of the telescopic component that extends out of the installation groove (402).

10. The targeted drug delivery device for fundus trauma as described in claim 9, characterized in that, The telescopic component includes a fixed cylinder (405) and a movable rod (403) that are nested together. One end of the movable rod (403) located inside the fixed cylinder (405) is fixed with a spring (404) to use the elastic force of the spring (404) to drive the movable rod (403) to move and seal the sealing cover (401).

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