Gel based on intelligent response type dynamic double-membrane hydration system as well as preparation method and application of gel

Abstract

The invention relates to the technical field of gel, in particular to gel based on an intelligent response type dynamic double-membrane hydration system and a preparation method and application of the gel. Tris (hydroxymethyl) aminomethane and carbomer cooperate to form a carbomer-pH-sensitive hydrogel matrix, the swelling degree of the carbomer-pH-sensitive hydrogel matrix is dynamically adjusted along with the change of the pH of a scar microenvironment, and the pH-sensitive hydrogel matrix has the advantages that the stability is high; a static sealing mode of a traditional silicone preparation is broken through, intelligent hydration management of different scar repairing stages (an acute stage and a mature stage) is achieved, an outer silicone isolating membrane formed by polydimethylsiloxane and an inner bioactive lipid membrane formed by composite plant active lipid achieve synergistic interaction, the hydration efficiency is improved by 70% or above, and the application range is wide. The nano transdermal carrier provided by the invention solves the problem of transdermal penetration of silicone and plant active ingredients, and targets to dermal fibroblasts, and clinical data shows that the scar softening rate is improved by more than 40% after the gel is used for 7 days, and the hyperpigmentation improvement rate is improved by more than 50% compared with that of a traditional product.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of gels, in particular to a gel based on an intelligent response type dynamic double-membrane hydration system and a preparation method and application thereof. BACKGROUND

[0002] Scar repair is an important clinical problem after skin wound healing. In the current mainstream repair scheme, silicone products are widely used due to their good sealing and hydration. Traditional silicone gel (such as polydimethylsiloxane) forms a breathable film on the skin surface, reduces water evaporation, increases the water content of the stratum corneum, and thus inhibits the activity of fibroblasts and the excessive deposition of collagen.

[0003] However, the existing technology has the following limitations: passive hydration: traditional silicone film only provides static sealing, and cannot dynamically adjust the degree of hydration according to the scar state; single component: single silicone preparation has limited effect on complex scar repair, especially insufficient control of pigmentation and inflammation; low transdermal efficiency: the molecular weight of silicone is large, and it is difficult to penetrate into deep scar tissue to play a role.

[0004] Based on this, the present application innovatively proposes a "dynamic double-membrane hydration system" which breaks through the technical bottleneck of traditional scar repair products through the synergistic design of intelligent response materials and nano carriers. SUMMARY

[0005] The purpose of the present application is to provide a gel based on an intelligent response type dynamic double-membrane hydration system and a preparation method and application thereof to overcome the deficiencies in the prior art.

[0006] The purpose of the present application is achieved by the following technical solution: a gel based on an intelligent response type dynamic double-membrane hydration system, which is composed of the following raw materials in weight percentage: Polydimethylsiloxane 12.5-26% Composite plant active lipid 3-8% Carbomer 0.8-1.2% Tris-hydroxymethyl aminomethane 0.6-2% Nano-transdermal carrier 1.5-3% Glycerol 2-7% The balance is deionized water. The composite plant active lipid is composed of camellia oil, olive oil and horse oil in a mass ratio of 4: (2-3): (2-3).

[0007] The composite plant active lipid contains: the camellia oil contains 24-29% linoleic acid, and the ratio of linoleic acid to oleic acid is 0.36-0.39; the olive oil contains ≥18% squalene; and the horse oil contains ≥65% unsaturated fatty acids.

[0008] wherein, in the complex plant active lipid: the camellia oil is obtained by urea inclusion treatment.

[0009] wherein, the method for urea inclusion treatment of the camellia oil comprises the following steps: (1) saponification: 100 parts by weight of camellia oil is mixed with 10-13 parts by weight of potassium hydroxide in anhydrous ethanol, and reacted at 70-80°C for 2-4 hours. After cooling, the pH of the system is adjusted to 4-5, and the mixed fatty acid in the upper layer is collected after standing and separation; (2) urea inclusion: the mixed fatty acid obtained in step (1) is mixed with urea at a mass ratio of 1:(1.2-1.5), and reacted at 70-80°C for 1-2 hours. Then it is cooled and crystallized at 2-6°C for 12-16 hours. Filtration is performed, and the filtrate is collected; (3) repeated inclusion: the filtrate obtained in step (2) is mixed with urea at a mass ratio of 1:(1.2-1.5), and the inclusion and filtration operations of step (2) are repeated 2 to 3 times; (4) post-treatment: the finally obtained filtrate is washed with water and dried to obtain the camellia oil.

[0010] wherein, the nano-transdermal carrier is a liposome-polymer hybrid nanoparticle with an average particle size of 80-120 nm and an encapsulation efficiency of ≥90%.

[0011] wherein, the nano-transdermal carrier is a PLGA-egg phospholipid hybrid particle.

[0012] A preparation method of a gel based on an intelligent response type dynamic double-membrane hydration system, comprising the following steps: Step (a): dispersing the formula amount of carbomer in part of deionized water, swelling for 24-48 hours; adding the formula amount of tris-hydroxymethyl aminomethane and glycerol, stirring uniformly to obtain an aqueous phase; Step (b): compounding the formula amount of dimethicone with the formula amount of nano-transdermal carrier under ultrasonic conditions to form a silicone nano-dispersion; then homogenizing the obtained silicone nano-dispersion with the formula amount of complex plant active lipid to obtain an oil phase; Step (c): adjusting the aqueous phase to pH 6.5-7.0, then adding the oil phase obtained in step (b) to the aqueous phase with adjusted pH under the conditions of 40-50°C and continuous stirring, supplementing deionized water and stirring homogenously, adjusting the pH to 5.5 after cooling to obtain a scar repair gel based on an intelligent response type dynamic double-membrane hydration system.

[0013] wherein, in step (c), the aqueous phase is adjusted to pH 6.5-7.0 using 1M sodium hydroxide aqueous solution, and the pH is adjusted to 5.5 after cooling using 1M tris-hydroxymethyl aminomethane hydrochloride solution.

[0014] In the above formula, the anhydrous ethanol used for the potassium hydroxide in the saponification of camellia oil refers to 10-13 parts by weight of potassium hydroxide dissolved in 250 parts by weight of anhydrous ethanol.

[0015] Application of a gel based on an intelligent response type dynamic double-membrane hydration system in a scar repair product. The gel forms an outer silicone isolation membrane and an inner bioactive lipid membrane after contacting the skin. The double-membrane system dynamically responds to changes in the microenvironment of the scar, intelligently adjusts the degree of hydration, and continuously releases active ingredients to inhibit the excessive proliferation of fibroblasts and collagen deposition.

[0016] The technical principle of the dynamic double-membrane hydration system of the present application is as follows: 1. Double-membrane synergistic mechanism: Outer silicone membrane: Polydimethylsiloxane forms a directional arrangement of molecular membrane on the skin surface, which is breathable and impermeable to water, preventing water evaporation and establishing a basic hydration environment.

[0017] Inner biological lipid membrane: Complex plant lipids (camellia oil / olive oil / horse oil) self-assemble to form a liquid crystal membrane in the deep epidermis, enhancing repair through the following pathways: Camellia oil (high linoleic acid type): Regulate the expression of inflammatory factor IL-1β, up-regulate the synthesis of filaggrin (FLG), and repair the skin barrier. Olive oil (squalene): Fill the lipid gap in the stratum corneum and enhance elasticity. Horse oil: Promote the transmembrane transport of active ingredients.

[0018] 2. Intelligent response hydration adjustment: Tris-hydroxymethyl aminomethane and carbomer synergistically form a carbomer-pH sensitive hydrogel matrix, and its swelling degree is dynamically adjusted with the change of the pH of the scar microenvironment:

[0019] 3. Synergistic effect of plant active ingredients: Camellia oil significantly enhances the anti-inflammatory effect after urea inclusion. The three oils are mixed in a scientific ratio to form a complex plant active lipid, which forms a stable complex liquid crystal phase through intermolecular forces, and has anti-inflammatory and barrier repair effects.

[0020] 4. Nanopercutaneous delivery system: The nanopercutaneous carrier uses a liposome-polymer hybrid nanoparticle (particle size 80-120 nm) to achieve microemulsification of silicone, improve permeability, and also protect plant active ingredients from oxidation and inactivation. Slow release control (24-hour release rate ≤80%).

[0021] The beneficial effects of the present application: the trimethylolamine of the present application and carbomer synergistically form a carbomer-pH sensitive hydrogel matrix, the swelling degree of which dynamically adjusts with the change of the pH of the scar microenvironment, breaking the static closed mode of traditional silicone preparations and realizing intelligent hydration management of different repair stages (acute stage, mature stage) of scars. The outer silicone isolation film formed by the polydimethylsiloxane and the inner bioactive lipid film formed by the composite plant active lipid have a synergistic effect, and the hydration efficiency is increased by more than 70%. The nano-transdermal carrier of the present application solves the transdermal problem of silicone and plant active ingredients, and targets the fibroblasts in the dermis. Clinical data show that the scar softening rate is increased by more than 40% after using the gel of the present application for 7 days, and the improvement rate of pigmentation is increased by more than 50% compared with traditional products. BRIEF DESCRIPTION OF DRAWINGS

[0022] Figure 1 : Schematic diagram of the action mechanism of the gel of the dynamic double-membrane hydration system of the present application; Figure 2 : Transdermal electron microscope photo of the nano-transdermal carrier of the present application; Figure 3 : Swelling rate curve of the pH-responsive gel of the present application.

[0023] REFERENCE NUMERALS 1 - Silicone isolation film, 2 - Bioactive lipid film, 3 - Nano-transdermal carrier. DETAILED DESCRIPTION

[0024] The present application is further described in conjunction with the following examples.

[0025] Example 1 A gel based on an intelligent response type dynamic double-membrane hydration system, which is composed of the following raw materials in weight percentage: Polydimethylsiloxane 12.5% Composite plant active lipid 3% Carbomer 0.8% Trimethylolamine 0.6% Nano-transdermal carrier 1.5% Glycerol 2% The balance is deionized water. The composite plant active lipid is composed of camellia oil, olive oil and horse oil in a mass ratio of 4:2:2.

[0026] The content of linoleic acid in the camellia oil is 24-29%, and the ratio of linoleic acid to oleic acid is 0.36-0.39; the squalene content of the olive oil is ≥18%; and the unsaturated fatty acid content of the horse oil is ≥65%.

[0027] Among them, the camellia oil in the compound plant active lipids is obtained by urea encapsulation.

[0028] The method for treating camellia oil with urea includes the following steps: (1) Saponification: 100 parts by weight of camellia oil are mixed with anhydrous ethanol containing 10 parts by weight of potassium hydroxide and reacted at 70°C for 4 hours. After cooling, the pH of the system is adjusted to 4. After standing and separation, the mixed fatty acids in the upper layer are collected. (2) Urea inclusion: The mixed fatty acids obtained in step (1) are combined with urea at a mass ratio of 1:1.2 and reacted at 70°C for 2 hours. Then, the mixture is refrigerated at 2°C for 16 hours to crystallize. The mixture is filtered and the filtrate is collected. (3) Repeated encapsulation: Mix the filtrate obtained in step (2) with urea at a mass ratio of 1:1.2, and repeat the encapsulation and filtration operation in step (2) twice; (4) Post-processing: The final filtrate is washed with water and dried to obtain the camellia oil.

[0029] The transdermal nanocarrier is a liposome-polymer hybrid nanoparticle with an average particle size of 80-120 nm and an encapsulation efficiency of ≥90%.

[0030] The nano-transdermal carrier PLGA-lecithin hybrid particles are mentioned above.

[0031] A method for preparing a gel based on a smart responsive dynamic dual-membrane hydration system includes the following steps: Step (a): Disperse the prescribed amount of carbomer in deionized water accounting for 60% of the total weight of deionized water, and allow it to swell for 24 hours; add the prescribed amount of tris(hydroxymethyl)aminomethane and glycerol, stir evenly, and obtain the aqueous phase; Step (b): The prescribed amount of polydimethylsiloxane and the prescribed amount of transdermal nanocarrier are combined under ultrasonic conditions to form a silicone nanodispersion; the obtained silicone nanodispersion is then homogenized with the prescribed amount of composite plant active lipids to obtain an oil phase; Step (c): Adjust the aqueous phase to pH 6.5, and then add the oil phase obtained in step (b) to the pH-adjusted aqueous phase under continuous stirring at 40°C. Add deionized water and stir to homogenize. After cooling, adjust the pH to 5.5 to obtain a scar repair gel based on a smart responsive dynamic dual-membrane hydration system.

[0032] Application of a gel based on a smart responsive dynamic dual-membrane hydration system in scar repair products.

[0033] Example 2 A gel based on a smart responsive dynamic dual-membrane hydration system, comprising the following raw materials by weight percentage: 20% polydimethylsiloxane 5% compound plant active lipids Carbomer 1.1% Tris(hydroxymethyl)aminomethane 1.2% Nanoparticle transdermal carrier 2.1% 5% glycerin The remainder is deionized water; The compound plant active lipids are composed of camellia oil, olive oil and horse oil in a mass ratio of 4:3:3.

[0034] Among them, the composite plant active lipids contain: camellia oil with a linoleic acid content of 24-29% and a linoleic acid to oleic acid ratio of 0.36-0.39; olive oil with a squalene content of ≥18%; and horse oil with an unsaturated fatty acid content of ≥65%.

[0035] Among them, the camellia oil in the compound plant active lipids is obtained by urea encapsulation.

[0036] The method for treating camellia oil with urea includes the following steps: (1) Saponification: 100 parts by weight of camellia oil are mixed with anhydrous ethanol containing 12 parts by weight of potassium hydroxide and reacted at 75°C for 3 hours. After cooling, the pH of the system is adjusted to 4.5. After standing and separation, the mixed fatty acids in the upper layer are collected. (2) Urea inclusion: The mixed fatty acids obtained in step (1) are mixed with urea at a mass ratio of 1:1.3, reacted at 75°C for 2 hours, and then refrigerated at 4°C for 15 hours to crystallize. The mixture is then filtered and the filtrate is collected. (3) Repeated inclusion: Mix the filtrate obtained in step (2) with urea at a mass ratio of 1:1.3, and repeat the inclusion and filtration operation in step (2) twice; (4) Post-processing: The final filtrate is washed with water and dried to obtain the camellia oil.

[0037] The transdermal nanocarrier is a liposome-polymer hybrid nanoparticle with an average particle size of 80-120 nm and an encapsulation efficiency of ≥90%.

[0038] The nano-transdermal carrier PLGA-lecithin hybrid particles are mentioned above.

[0039] A method for preparing a gel based on a smart responsive dynamic dual-membrane hydration system includes the following steps: Step (a): Disperse the prescribed amount of carbomer in deionized water accounting for 65% of the total weight of deionized water, and allow it to swell for 36 hours; add the prescribed amount of tris(hydroxymethyl)aminomethane and glycerol, stir evenly, and obtain the aqueous phase; Step (b): The prescribed amount of polydimethylsiloxane and the prescribed amount of transdermal nanocarrier are combined under ultrasonic conditions to form a silicone nanodispersion; the obtained silicone nanodispersion is then homogenized with the prescribed amount of composite plant active lipids to obtain an oil phase; Step (c): Adjust the aqueous phase to pH 6.5, and then add the oil phase obtained in step (b) to the pH-adjusted aqueous phase under continuous stirring at 45°C. Add deionized water and stir to homogenize. After cooling, adjust the pH to 5.5 to obtain a scar repair gel based on a smart responsive dynamic dual-membrane hydration system.

[0040] Application of a gel based on a smart responsive dynamic dual-membrane hydration system in scar repair products.

[0041] Example 3 A gel based on a smart responsive dynamic dual-membrane hydration system, comprising the following raw materials by weight percentage: 25% polydimethylsiloxane 8% compound plant active lipids Carbomer 1.2% 2% Tris(hydroxymethyl)aminomethane 3% of nanotransdermal carriers 7% glycerol The remainder is deionized water; The compound plant active lipids are composed of camellia oil, olive oil and horse oil in a mass ratio of 4:3:3.

[0042] Among them, the composite plant active lipids contain: camellia oil with a linoleic acid content of 24-29% and a linoleic acid to oleic acid ratio of 0.36-0.39; olive oil with a squalene content of ≥18%; and horse oil with an unsaturated fatty acid content of ≥65%.

[0043] Among them, the camellia oil in the compound plant active lipids is obtained by urea encapsulation.

[0044] The method for treating camellia oil with urea includes the following steps: (1) Saponification: 100 parts by weight of camellia oil are mixed with anhydrous ethanol containing 13 parts by weight of potassium hydroxide and reacted at 80°C for 2 hours. After cooling, the pH of the system is adjusted to 5, and the mixture of fatty acids in the upper layer is collected after standing and separation. (2) Urea inclusion: The mixed fatty acids obtained in step (1) are mixed with urea at a mass ratio of 1:1.5, reacted at 80°C for 1 hour, and then refrigerated at 6°C for 12 hours to crystallize. The mixture is then filtered and the filtrate is collected. (3) Repeated encapsulation: Mix the filtrate obtained in step (2) with urea at a mass ratio of 1:1.5, and repeat the encapsulation and filtration operation in step (2) 3 times; (4) Post-processing: The final filtrate is washed with water and dried to obtain the camellia oil.

[0045] The transdermal nanocarrier is a liposome-polymer hybrid nanoparticle with an average particle size of 80-120 nm and an encapsulation efficiency of ≥90%.

[0046] The nano-transdermal carrier PLGA-lecithin hybrid particles are mentioned above.

[0047] A method for preparing a gel based on a smart responsive dynamic dual-membrane hydration system includes the following steps: Step (a): Disperse the prescribed amount of carbomer in deionized water accounting for 70% of the total weight of deionized water, and allow it to swell for 48 hours; add the prescribed amount of tris(hydroxymethyl)aminomethane and glycerol, stir until homogeneous, and obtain the aqueous phase; Step (b): The prescribed amount of polydimethylsiloxane and the prescribed amount of transdermal nanocarrier are combined under ultrasonic conditions to form a silicone nanodispersion; the obtained silicone nanodispersion is then homogenized with the prescribed amount of composite plant active lipids to obtain an oil phase; Step (c): Adjust the aqueous phase to pH 7.0, and then add the oil phase obtained in step (b) to the pH-adjusted aqueous phase under continuous stirring at 50°C. Add deionized water and stir to homogenize. After cooling, adjust the pH to 5.5 to obtain a scar repair gel based on a smart responsive dynamic dual-membrane hydration system.

[0048] Application of a gel based on a smart responsive dynamic dual-membrane hydration system in scar repair products.

[0049] Experimental data 1. Verification of double-film formation: Using confocal Raman microscopy to scan ex vivo human skin tissue after applying the gel, the spatial distribution of specific molecules was traced, and a strong silicone characteristic peak (490 cm⁻¹) was observed on the skin surface (0-5 μm depth). -1 This forms a continuous and uniform film-like structure, and the characteristic peak of linoleic acid (1650 cm⁻¹) is observed in the deep layer of the stratum corneum (15-30 μm depth). -1 The significant enrichment of [a substance] confirms that the active lipids from the compound plant successfully penetrated and self-assembled to form the inner biomembrane. This result directly demonstrates the successful construction of the "dynamic double membrane structure". Figure 1 This is a schematic diagram of the mechanism of action of the gel in the dynamic dual-membrane hydration system of the present invention. As can be seen from the schematic diagram, the outer layer is a continuous outer silicone isolation membrane 1, the inner layer is a bioactive lipid membrane 2, and the nano-transdermal carrier 3 shuttles between them.

[0050] 2. Transdermal validation of nanocarriers Transmission electron microscopy was used to observe ex vivo human skin sections after the gel was applied, and transdermal electron micrographs of the nanocarrier were obtained. Figure 2 As clearly observed in the image, a large number of uniformly sized (approximately 80-120 nm) nanocarriers (highlighted particles in the image) have successfully penetrated and are densely distributed in the lipid interstices of the stratum corneum, showing a tendency to penetrate deeper into the active epidermis. This image directly confirms that the nanodelivery system constructed in this invention can effectively overcome the skin barrier, laying the foundation for achieving deep repair.

[0051] 3. pH-responsive gel swelling rate The equilibrium swelling ratio of the gel of this invention in different pH buffer solutions was determined by gravimetric method to reveal the underlying basis of its intelligent response. Figure 3 This is the pH-responsive gel swelling rate curve of the present invention, which shows the variation characteristics of gel swelling degree under different pH values. Figure 3 It is clearly shown that the swelling behavior of the gel is strongly dependent on the ambient pH value. With increasing pH, the equilibrium swelling ratio of the gel shows a significant upward trend—for example, the swelling ratio is 7.3 g / g at pH=2, rises to 13.5 g / g at pH=6, and further increases to 27.8 g / g at pH=10.

[0052] Based on the simulated scar microenvironment conditions, it can be seen that under the simulated acute phase scar pH 6.5 conditions, the gel rapidly absorbs water due to the increased repulsion between polymer chains, and the swelling rate can reach a relatively high level; while under the simulated mature phase scar pH 5.2 conditions, the gel network shrinks, and the swelling rate is relatively lower. This pH-responsive swelling characteristic is the core intrinsic basis for the gel to achieve its intelligent function.

[0053] 4. pH-responsive dynamic hydration capacity Using a Franz diffusion cell, the water permeability and retention capacity of the gel were measured in receptor solutions at different pH values ​​(simulating acute-phase scar pH 6.5 and mature-phase scar pH 5.2). The test results are shown in Table 1. Table 1 shows that in the pH environment of acute-phase scars, the hydration-related indicators all increased by more than 100%, providing moisture to scar tissue faster, more, and for longer. Even in the mature-phase scar environment, the increase was maintained at over 70%, demonstrating comprehensive superior hydration performance compared to traditional silicone gels, and intelligently responding to pH changes. It provides rapid and potent hydration during the inflammatory phase (higher pH) and transitions to gentle and continuous hydration during the mature phase (normal pH), achieving "dynamic" regulation.

[0054]

[0055] 5. Evaluation of clinical efficacy and safety 120 patients with postoperative linear scars were randomly divided into an experimental group (using the gel of this invention) and a control group (using commercially available conventional silicone gel). Usage: twice daily for 12 weeks. Assessment tools: Vancouver Scar Scale, Cutometer skin elasticity tester, Mexameter erythema / melanin index meter, and patient satisfaction questionnaire were used. Clinical results (after 12 weeks of use) are shown in Table 2.

[0056]

[0057] This invention significantly reduced the total score and sub-indices (hardness, thickness, vascular distribution / erythema, and pigmentation) on the Vancouver Scar Scale (an authoritative assessment tool), with improvements ranging from 41.2% to 50.0%, and P < 0.01 (statistically significant). Compared to the control group, the gel of this invention more effectively reduced scar hardness and thickness, faded erythema and pigmentation, making scars appear closer to normal skin. The erythema index improvement rate of this invention reached 75.1%, an increase of 55.5% compared to the control group (48.3%) (P < 0.01), indicating a more prominent effect on the reduction of inflammatory erythema in scars. The skin elasticity R5 value of this invention increased by 18.1% (P < 0.05), indicating that the gel can better restore the elasticity of the skin in the scar area and reduce stiffness. The overall patient satisfaction rate of the gel of this invention reached 92.5%, an increase of 20.4% compared to the control group (76.8%), indicating that its user experience and perceived effects better met patient expectations. During the entire 12-week trial, no adverse reactions related to the product (such as allergies, contact dermatitis, etc.) occurred in the experimental group. Subjects reported that the gel had a refreshing texture, formed a film quickly, had no obvious stickiness, and had good compliance.

[0058] The above experiments used a randomly selected gel from Example 2 of the present invention. The experimental data show that the present invention has comprehensive advantages in dynamic hydration, synergistic repair, precise delivery and long-term safety. Its various performance indicators are significantly better than traditional scar repair products.

[0059] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, and are not intended to limit the scope of protection of the present invention. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solutions of the present invention without departing from the essence and scope of the technical solutions of the present invention.

Claims

1. A gel based on a smart responsive dynamic dual-membrane hydration system, characterized in that, It consists of the following raw materials by weight percentage: Polydimethylsiloxane 12.5-26% Complex plant-based active lipids 3-8% Carbomer 0.8-1.2% Tris(hydroxymethyl)aminomethane 0.6-2% Nanoparticle transdermal carrier 1.5-3% Glycerin 2-7% The remainder is deionized water; The compound plant active lipids are composed of camellia oil, olive oil and horse oil in a mass ratio of 4:(2-3):(2-3).

2. The gel based on a smart responsive dynamic dual-membrane hydration system according to claim 1, characterized in that, The compound plant active lipids contain: camellia oil with a linoleic acid content of 24-29% and a linoleic acid to oleic acid ratio of 0.36-0.39; olive oil with a squalene content of ≥18%; and horse oil with an unsaturated fatty acid content of ≥65%.

3. The gel based on a smart responsive dynamic dual-membrane hydration system according to claim 1, characterized in that, The composite plant active lipids include camellia oil, which is obtained by urea encapsulation.

4. The gel based on a smart responsive dynamic dual-membrane hydration system according to claim 3, characterized in that, The method for encapsulating camellia oil with urea includes the following steps: (1) Saponification: Mix 100 parts by weight of camellia oil with anhydrous ethanol containing 10-13 parts by weight of potassium hydroxide, react at 70-80℃ for 2-4 hours, cool, adjust the pH of the system to 4-5, let stand and separate, and collect the mixed fatty acids in the upper layer. (2) Urea inclusion: The mixed fatty acids obtained in step (1) are mixed with urea at a mass ratio of 1:(1.2-1.5), reacted at 70-80℃ for 1-2 hours, and then refrigerated at 2-6℃ for 12-16 hours to crystallize. The mixture is then filtered and the filtrate is collected. (3) Repeated encapsulation: Mix the filtrate obtained in step (2) with urea at a mass ratio of 1:(1.2-1.5), and repeat the encapsulation and filtration operation in step (2) 2 to 3 times; (4) Post-processing: The final filtrate is washed with water and dried to obtain the camellia oil.

5. The gel based on a smart responsive dynamic dual-membrane hydration system according to claim 1, characterized in that, The transdermal nanocarrier is a liposome-polymer hybrid nanoparticle with an average particle size of 80-120 nm and an encapsulation efficiency of ≥90%.

6. A gel based on a smart responsive dynamic dual-membrane hydration system according to claim 5, characterized in that, The nanotransdermal carrier PLGA-lecithin hybrid particles.

7. A method for preparing a gel based on a smart responsive dynamic dual-membrane hydration system as described in any one of claims 1-6, characterized in that, Includes the following steps: Step (a): Disperse the prescribed amount of carbomer in a portion of deionized water and allow it to swell for 24-48 hours; add the prescribed amounts of tris(hydroxymethyl)aminomethane and glycerol, stir until homogeneous, and obtain the aqueous phase; Step (b): The prescribed amount of polydimethylsiloxane and the prescribed amount of transdermal nanocarrier are combined under ultrasonic conditions to form a silicone nanodispersion; the obtained silicone nanodispersion is then homogenized with the prescribed amount of composite plant active lipids to obtain an oil phase; Step (c): Adjust the aqueous phase to pH 6.5-7.0, and then add the oil phase obtained in step (b) to the pH-adjusted aqueous phase under continuous stirring at 40-50℃. Add deionized water and stir to homogenize. After cooling, adjust the pH to 5.5 to obtain a scar repair gel based on a smart responsive dynamic dual-membrane hydration system.

8. The application of a gel based on a smart responsive dynamic dual-membrane hydration system as described in any one of claims 1-6 in scar repair products.

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