Chinese and western medicine composition for treating bone tuberculosis, Chinese and western medicine preparation, preparation method and application

Abstract

The invention relates to a Chinese and western medicine composition for treating bone tuberculosis, a Chinese and western medicine preparation, a preparation method and application. The composition is prepared from the following components in parts by weight: 5 to 15 parts of radix angelicae sinensis, 3 to 10 parts of rhizoma atractylodis macrocephalae, 5 to 10 parts of radix codonopsis, 5 to 10 parts of poria cocos, 5 to 15 parts of raw rhizoma atractylodis, 5 to 10 parts of radix angelicae pubescentis, 5 to 10 parts of rhizoma seu radix notopterygii, 1 to 5 parts of herba asari, 5 to 10 parts of flos carthami, 3 to 10 parts of radix polygalae, 3 to 10 parts of radix platycodonis, 5 to 10 parts of radix saposhnikoviae, 0.3 to 0.7 part of borneol, 3 to 5 parts of spica prunellae, 3 to 5 parts of rhizoma chuanxiong, 5 to 10 parts of ramie and 10 to 15 parts of vitamin B6. The medicine is applied to treatment of various bone tuberculosis. The Chinese and western medicine composition provided by the invention is simple and proper in compatibility, and has the effect of treating extremely high bone tuberculosis through clinical examination for many years.

Description

Technical Field

[0001] This invention relates to the field of Chinese and Western medicine compositions, and more specifically to a Chinese and Western medicine composition, Chinese and Western medicine preparation, preparation method, and application for treating bone tuberculosis. Background Technology

[0002] Bone tuberculosis, commonly known as bone consumption, is one of the most common chronic diseases in orthopedics. It has a high incidence rate and can occur in any bone tissue throughout the body, but the most common types are thoracic spine tuberculosis, lumbar spine tuberculosis, hip joint tuberculosis, femoral bone tuberculosis, knee joint tuberculosis, lower leg bone tuberculosis, rib tuberculosis, and wrist bone tuberculosis. If treatment is delayed in clinical practice, it can lead to loss of working ability and endanger the patient's life.

[0003] The main pathogenesis, according to Western medicine, is that tuberculosis bacteria generally cannot directly invade bone tissue. Therefore, most cases of bone tuberculosis are secondary to pulmonary tuberculosis, with a small number of patients developing secondary digestive system tuberculosis, and occasionally infection from lymph nodes near the bone. Traditional Chinese medicine believes that bone tuberculosis is caused by deficiency of vital energy, injury to tendons and bones, disharmony of qi and blood, accumulation and stagnation, which transforms into phlegm and turbidity, flowing to various joints and causing disease. Traditional Chinese medicine emphasizes the word "deficiency," and also believes that the disease is mostly due to congenital bone underdevelopment or long-term kidney yin deficiency, insufficient bone marrow, and external pathogens taking advantage of the weakness to invade.

[0004] Currently, traditional treatments for bone tuberculosis still rely on large doses of Western medicine for anti-tuberculosis and the use of folk remedies, which exacerbate the disease. The extensive use of anti-tuberculosis drugs severely damages the patient's liver, kidneys, and digestive system, causing unnecessary suffering and financial burdens on families and society. Treatment for bone tuberculosis also involves grueling surgery, which is highly destructive and can easily lead to paraplegia or numerous postoperative complications. Postoperatively, the patient still requires anti-tuberculosis drugs, continuing the double burden. Furthermore, the high cost of surgery makes it unaffordable for many families.

[0005] With the rapid development of integrated traditional Chinese and Western medicine, and people's growing preference for natural products, traditional Chinese medicine and its combined use in the treatment of bone tuberculosis are gaining increasing attention and recognition. Traditional Chinese medicine often employs methods such as tonifying the liver and kidneys, warming the meridians and resolving phlegm, strengthening the body's resistance, and addressing blood deficiency in the treatment of bone tuberculosis. Combined with the effects of Western medicine, this approach achieves a more comprehensive and effective treatment for bone tuberculosis, truly achieving both symptomatic relief and a cure. Currently, there are no drugs on the market that combine traditional Chinese and Western medicine for the comprehensive and highly effective treatment of bone tuberculosis, without damaging the patient's organs or causing recurrence. Summary of the Invention

[0006] The purpose of this invention is to provide a combination of traditional Chinese and Western medicines for treating bone tuberculosis, a preparation of traditional Chinese and Western medicines, a preparation method, and an application. This drug is developed targeting the etiology and pathogenesis of bone tuberculosis and has a broad-spectrum therapeutic effect on bone tuberculosis, truly achieving a combination of traditional Chinese and Western medicines for treating bone tuberculosis by addressing both the symptoms and the root cause.

[0007] The technical solution of this invention:

[0008] A traditional Chinese and Western medicine composition for treating bone tuberculosis, wherein the composition comprises the following components in parts by weight: Angelica sinensis 5-15 parts, Atractylodes macrocephala 3-10 parts, Codonopsis pilosula 5-10 parts, Poria cocos 5-10 parts, Atractylodes lancea 5-15 parts, Ligusticum striatum 5-10 parts, Notopterygium incisum 5-10 parts, Asarum heterotropoides 1-5 parts, Carthamus tinctorius 5-10 parts, Polygala tenuifolia 3-10 parts, Platycodon grandiflorus 3-10 parts, Saposhnikovia divaricata 5-10 parts, Borneol 0.3-0.7 parts, Prunella vulgaris 3-5 parts, Ligusticum striatum 3-5 parts, Isomizone 5-10 parts, and Vitamin B6 10-15 parts.

[0009] The composition comprises the following ingredients in parts by weight: Angelica sinensis 5 parts, Atractylodes macrocephala 3 parts, Codonopsis pilosula 5 parts, Poria cocos 5 parts, Atractylodes lancea 5 parts, Ligusticum striatum 5 parts, Notopterygium incisum 5 parts, Asarum heterotropoides 1 part, Carthamus tinctorius 5 parts, Polygala tenuifolia 3 parts, Platycodon grandiflorus 3 parts, Saposhnikovia divaricata 5 parts, Borneol 0.3 parts, Prunella vulgaris 3 parts, Ligusticum chuanxiong 3 parts, Isomizone 5 parts, and Vitamin B6 10 parts.

[0010] Application of a combination of traditional Chinese and Western medicines for treating various types of bone tuberculosis.

[0011] The Chinese and Western medicine preparations for treating various types of bone tuberculosis are formulated from the above-mentioned Chinese herbal composition.

[0012] The dosage form includes powder, tablet, granule or capsule.

[0013] A combination of traditional Chinese and Western medicine for treating bone tuberculosis, S1: Angelica sinensis, Atractylodes macrocephala, Codonopsis pilosula, Poria cocos, Atractylodes lancea, Ligusticum striatum, Notopterygium incisum, Asarum heterotropoides, Carthamus tinctorius, Polygala tenuifolia, Platycodon grandiflorus, Saposhnikovia divaricata, Borneol, Prunella vulgaris, Ligusticum chuanxiong, Isomilac, and Vitamin B6 are weighed in proportion, pulverized, and sieved through a 120-mesh sieve for later use.

[0014] S2 Weigh the obtained bone tuberculosis treatment powder in 1.0 gram portions and package or encapsulate it for later use.

[0015] A traditional Chinese and Western medicine preparation for treating bone tuberculosis.

[0016] Preferred features and beneficial effects of the present invention:

[0017] 1. The traditional Chinese and Western medicine combination provided by this invention is concise and well-matched. After years of clinical treatment, it has proven to be highly effective in treating bone tuberculosis. The various symptoms treated by this invention are all due to deficiency of vital energy, disharmony of qi and blood, accumulation and stagnation transforming into phlegm and turbidity, which flows into various joints and causes disease. The Qing Dynasty medical text *Collection of Experiences in Ulcer Treatment* states, "Congenital deficiency, deficiency of the three yin meridians, or injury causing qi to be unable to rise and blood to be unable to flow, resulting in stagnation in the meridians. This causes a dull, piercing pain, thus leading to this disease." Therefore, the treatment should focus on tonifying the middle jiao and replenishing qi, supporting deficiency and replenishing damage, eliminating phlegm and stagnation, and nourishing blood and harmonizing the body. In this formula, Angelica sinensis (Dang Gui): sweet and pungent in taste, warm in nature, nourishes blood and heart, strengthens the body and replenishes deficiencies, removes blood stasis and promotes new blood production; Codonopsis pilosula (Dang Shen): sweet and neutral in nature, tonifies the middle energizer and benefits qi, nourishes blood and harmonizes the body; Carthamus tinctorius (Hong Hua): pungent in taste, warm in nature, promotes menstruation and nourishes blood, removes blood stasis; Ligusticum chuanxiong (Chuan Xiong): pungent in taste, warm in nature, invigorates blood and promotes menstruation, dispels wind and relieves pain; Atractylodes macrocephala (Bai Zhu): sweet and bitter in taste, warm in nature, promotes qi circulation and eliminates turbidity, removes dampness and eliminates phlegm; Polygala tenuifolia (Yuan Zhi): bitter and pungent in taste, warm in nature, nourishes blood, calms the mind, soothes the heart, resolves phlegm and dissipates stagnation; Notopterygium incisum (Da Huo) and Notopterygium incisum (Qiang Huo): bitter and pungent in taste, warm in nature, both have the effects of dispelling wind and dampness, relaxing muscles and tendons; Platycodon grandiflorus (Jie Geng): bitter and pungent in taste, neutral in nature, removes phlegm and turbidity, opens the chest and promotes blood circulation. All of the above are the principal herbs. Raw Atractylodes lancea: pungent and warm in nature, it strengthens the spleen and dries dampness. Its pungent nature disperses sweating, dries dampness and resolves turbidity, enhancing the spleen-strengthening and stomach-strengthening effects of the principal herb, ensuring the spleen's strength and thus the proper generation of qi and blood, which in turn promotes blood circulation. Poria cocos: sweet and bland in taste, neutral in nature, it drains dampness, clears the orifices, and eliminates phlegm. Prunella vulgaris: bitter and pungent in taste, cold in nature, its pungent nature disperses stagnation, its bitter and cold nature clears heat, breaking up masses and dissipating nodules. Saposhnikovia divaricata: pungent in taste, slightly warm in nature, its pungent nature disperses, its slightly warm nature is not drying, and it is effective in treating wind-related ailments, including chills and fever. The combination of these four herbs strengthens the spleen and stomach, breaks up masses and dissipates nodules, and has a diaphoretic and cooling effect on patients with bone tuberculosis and fever, thus enhancing the qi and blood generation of the principal herb. All of these are assistant herbs. Asarum heterotropoides: pungent and warm in nature, it clears the orifices and treats chills, fever, headache, and body aches. Borneol: bitter and pungent in taste, slightly cold in nature, it clears heat, brightens the eyes, reduces swelling, and relieves pain. The combination of these two herbs enhances the cooling and diaphoretic effects of the adjuvant herbs, allowing the principal herb to better exert its efficacy. Isoniazid, also known as isoniazid, is a compound of isoniazid and hydrazine. Its anti-tuberculosis mechanism involves isoniazid binding to aldehydes, ketones, acetone, etc., in the body. Pyridoxal or pyruvate are essential substances for the metabolism of Mycobacterium tuberculosis. Isoniazid affects the growth and reproduction of Mycobacterium tuberculosis by binding to these substances. It is well known that relying solely on isoniazid for treating bone tuberculosis is insufficient and cannot achieve a cure. Vitamin B6 is given because long-term use of isoniazid can lead to excessive excretion of vitamin B6 in urine, resulting in vitamin B6 deficiency and potentially causing central nervous system symptoms and peripheral neuritis. This is primarily to prevent the toxic side effects of isoniazid. The addition of isoniazid to this formula improves the cure rate for patients with bone tuberculosis, making this invention a true combination of traditional Chinese and Western medicine in the treatment of bone tuberculosis, achieving the goal of treating both the symptoms and the root cause, and eliminating various symptoms. It is currently the most ideal, complete, and effective formula for treating bone tuberculosis.

[0018] 2. The preparation method of the bone tuberculosis treatment complex provided by this invention is simple. The resulting complex has the effects of tonifying the liver and kidneys, warming the meridians and resolving phlegm, strengthening the body's resistance and detoxifying, removing blood stasis and promoting new tissue growth, and strengthening the body's resistance and blood deficiency. Combined with isoniazid for anti-tuberculosis, it achieves a dual effect in treatment, making this invention more complete and perfect in treating bone tuberculosis, truly achieving the goal of treating both the symptoms and the root cause. Clinical observation and follow-up of bone tuberculosis treated with this invention show significant efficacy, with obvious effects often seen within one course of treatment (about 50 days), and rapid elimination of clinical symptoms. X-rays and CT scans show obvious new bone formation at the site of bone erosion. The effective rate is 100%, and the cure rate is 95.69%, significantly superior to current conservative and surgical treatments.

[0019] 3. This invention truly improves the quality of the composition through the combined application of the Western medicine isoflavone.

[0020] 4. The medicine for treating bone tuberculosis provided by this invention has the effects of tonifying the liver and kidneys, warming the meridians and resolving phlegm, supporting the body's resistance and detoxifying, removing blood stasis and promoting new tissue growth, supporting the body's resistance and blood deficiency, and anti-tuberculosis. It has a rapid onset of action and obvious effects. Most clinical symptoms are eliminated after one month of medication. It is not addictive, has no toxic side effects, and is simple to prepare and take. Detailed Implementation

[0021] Those skilled in the art can draw upon the content of this document to appropriately modify the component or process parameters. It should be particularly noted that all similar substitutions and modifications are obvious to those skilled in the art and are considered to be included within the scope of protection of this invention.

[0022] This invention discloses a combination of traditional Chinese and Western medicine for treating bone tuberculosis, a preparation method thereof, and its application [named Compound Anti-Bone Tuberculosis Powder], which is a family secret recipe passed down for many years. The inventor of this drug, Jin Lixin, is a senior medical professional with broad knowledge and rich clinical experience.

[0023] From the perspective of traditional Chinese medicine, the pathogenesis of bone tuberculosis is inseparable from the concept of "deficiency," namely, deficiency of vital energy, disharmony of qi and blood, accumulation of stagnation and phlegm, which flows into various joints and causes disease. The purpose of this invention is to develop a treatment for bone tuberculosis that has a broad-spectrum therapeutic effect and is effective for most syndrome types. It is currently the most ideal and reasonable combination of traditional Chinese and Western medicine for the treatment of bone tuberculosis, truly achieving both symptomatic and root-cause treatment.

[0024] The machines and pharmaceuticals involved in the embodiments of this invention are as follows:

[0025] A regular grinder will suffice. The safflower in the compound can be any safflower. The Western medicine isoflavones and vitamin B6 can be purchased from a reputable pharmacy.

[0026] For the treatment of various bone tuberculosis complexes, the Chinese medicine portion must be purchased from reputable manufacturers and pharmacies to ensure the purity of the medicines and that they are free from deterioration, rot, and mold.

[0027] Example 1

[0028] This embodiment provides a traditional Chinese and Western medicine composition for treating bone tuberculosis. The composition contains 10 parts Angelica sinensis, 6 parts Atractylodes macrocephala, 6 parts Codonopsis pilosula, 8 parts Poria cocos, 10 parts Atractylodes lancea, 8 parts Notopterygium incisum, 2 parts Asarum heterotropoides, 8 parts Carthamus tinctorius, 6 parts Polygala tenuifolia, 8 parts Platycodon grandiflorus, 6 parts Saposhnikovia divaricata, 0.5 parts Borneol, 4 parts Prunella vulgaris, 4 parts Ligusticum chuanxiong, 8 parts Isomizone, and 10 parts Vitamin B6.

[0029] 93 patients with bone tuberculosis

[0030] Table 1

[0031] Statistical table of bone tuberculosis occurrence sites

[0032] Location of occurrence Thoracic tuberculosis Lumbar tuberculosis Hip joint tuberculosis femoral tuberculosis Knee tuberculosis tuberculosis of the lower leg bone Rib tuberculosis wrist bone tuberculosis Number of examples 23 cases 32 cases 11 cases 5 cases 7 cases 4 cases 5 cases 6 cases total 93 cases

[0033] The statistics in Table 1 show that bone tuberculosis can occur in any bone tissue, but the most common sites in clinical practice are the thoracic spine, lumbar spine, and hip joint, accounting for a large proportion of 66 cases, or about 71% of the total cases. The next most common sites are femoral, knee, lower leg bone tuberculosis, rib, and wrist bone tuberculosis, with 27 cases, accounting for more than 29% of the total cases, based on clinical reports.

[0034] Efficacy criteria: 23 cases of thoracic spine tuberculosis, 32 cases of lumbar spine tuberculosis, 11 cases of hip joint tuberculosis, 5 cases of femoral tuberculosis, 7 cases of knee joint tuberculosis, 4 cases of lower leg tuberculosis, 5 cases of rib tuberculosis, and 6 cases of wrist joint tuberculosis. All of the above cases of bone tuberculosis were treated with a combination of traditional Chinese and Western medicine for bone tuberculosis. The efficacy was judged based on the treatment results. A total of 66 cases of thoracic spine tuberculosis, lumbar spine tuberculosis, and hip joint tuberculosis were treated. After one course of treatment (50 days), the clinical symptoms of all cases were largely eliminated. All of them underwent X-ray and CT scans, which showed that the bone loss areas were all significantly regenerated. All 66 cases were cured after two courses of treatment, with a cure rate of 100%. The remaining 27 cases of femoral tuberculosis, knee joint tuberculosis, lower leg tuberculosis, rib tuberculosis, and wrist bone tuberculosis all showed significant clinical symptom relief after one course of treatment. X-rays revealed significant new bone formation in the bone loss areas, resulting in an effective rate of 100%. Two cases of rib bone tuberculosis and two cases of wrist bone tuberculosis were not observed. Four cases were effective, and the remaining 23 cases were cured. The overall effective rate was 100%, and the overall cure rate was 95.69%.

[0035] Table 2

[0036]

[0037] Table 2 shows that this invention is highly effective in treating bone tuberculosis in the thoracic spine, lumbar spine, hip joint, femur, knee joint, and lower leg bones, with a short treatment course. However, the treatment time is longer for rib and wrist bone tuberculosis, which may be related to poor absorption of the drug at the peripheral sites. After taking the medicine, the symptoms of 93 cases of bone tuberculosis disappeared significantly. X-ray and CT scans showed that the new bone formation in the eroded areas was ideal. Except for 4 cases that were not followed up, all the rest were cured. The effective rate of this invention reached 100%, and the cure rate reached 95.69%.

[0038] Usage and dosage: For oral administration, take 1.0 gram of the above compound with warm water twice a day. Avoid fish.

[0039] The overall effective rate of treatment was 100%, and the overall cure rate was 95.69%.

[0040] Because the combined Chinese and Western medicine treatment for various types of bone tuberculosis described in this embodiment has a high efficacy and cure rate, and is currently superior to conservative treatment and surgical treatment, it can be used for the treatment of various types of bone tuberculosis.

[0041] Investigation and follow-up: An investigation and follow-up were conducted on the treatment of various types of bone tuberculosis using the combination of traditional Chinese and Western medicine of this invention. All cases were investigated and followed up by telephone information and regular follow-up questionnaires. The longest follow-up period was 15 years (38 cases), 10 years (29 cases), and 5 years (22 cases), and none of them relapsed.

[0042] Example 2

[0043] This embodiment provides a method for preparing a complex for treating various types of bone tuberculosis. The method involves weighing the following ingredients in a specific ratio: 5 parts Angelica sinensis, 3 parts Atractylodes macrocephala, 5 parts Codonopsis pilosula, 5 parts Poria cocos, 5 parts Atractylodes lancea, 5 parts Notopterygium incisum, 1 part Asarum heterotropoides, 5 parts Carthamus tinctorius, 3 parts Polygala tenuifolia, 3 parts Platycodon grandiflorus, 5 parts Saposhnikovia divaricata, 0.3 parts Borneol, 3 parts Prunella vulgaris, 3 parts Ligusticum chuanxiong, 5 parts Isomizone, and 10 parts Vitamin B6. The mixture is then pulverized and passed through a 120-mesh sieve and thoroughly stirred.

[0044] Example 3

[0045] In a clinical trial, 93 patients with various types of bone tuberculosis were treated with this invention. There were 54 male patients and 39 female patients. The oldest patient was 77 years old and the youngest was 28 years old, with an average age of 52.5 years. Among them, there were 23 cases of thoracic spine tuberculosis, 32 cases of lumbar spine tuberculosis, 11 cases of hip joint tuberculosis, 5 cases of femoral tuberculosis, 7 cases of knee joint tuberculosis, 4 cases of lower leg bone tuberculosis, 5 cases of rib bone tuberculosis, and 6 cases of wrist joint bone tuberculosis. All patients were diagnosed by X-ray and CT. 82 patients were cured after 2 courses of treatment and 7 patients were cured after 3 courses of treatment. The remaining 4 patients were not followed up.

[0046] The efficacy criteria were determined based on the disappearance of clinical symptoms and X-ray or CT scans. In a study of 93 cases of various types of bone tuberculosis treated with this invention, the clinical symptom response rate was 100%. After two courses of treatment, X-ray or CT scans showed new bone formation in the missing bone. After two courses of treatment, the bone quality of the affected bone was normal in 82 cases, and after three courses of treatment, the bone quality of the affected bone was normal in 7 cases. Of the 93 patients with bone tuberculosis treated with this invention, 4 were lost to follow-up after two courses of treatment, and the remaining patients were cured, resulting in an efficacy rate of 100% and a total cure rate of 95.69%.

[0047] Results: 93 cases of various bone tuberculosis were treated with this invention. Among them, 3 cases of lumbar tuberculosis were cured after recurrence, 1 case of femoral tuberculosis and 1 case of wrist joint tuberculosis were cured after recurrence. The total effective rate of the 93 cases was 100%, and the cure rate was 95.69%.

[0048] In contrast, the current treatment of various types of bone tuberculosis continues to rely primarily on conservative and surgical methods.

[0049] (1) Conservative treatment mainly uses anti-tuberculosis drugs and folk remedies. Folk remedies cannot completely cure the disease. Anti-tuberculosis drugs cause great damage to the liver, kidneys and gastrointestinal tract. Surgical treatment is expensive and has serious postoperative complications, some of which can lead to paralysis. At present, there is still no ideal treatment for various types of bone tuberculosis.

[0050] (2) The present invention is currently the most ideal treatment for various types of bone tuberculosis. The present invention causes little damage to the liver, kidneys and gastrointestinal tract. Clinical follow-up surveys show that no patients treated so far have relapsed.

[0051] (3) This invention has few toxic side effects, is non-addictive, non-cumulative, economical, highly effective, and can be used by people with weak constitutions.

[0052] (4) The present invention is simple to prepare and easy to use. The purpose of applying vitamin B6 in the present invention is to reduce the toxicity of isoniazid and to ensure that the present invention is non-toxic.

[0053] Typical Cases

[0054] Case 1

[0055] Patient: Male, 46 years old, residing in Changtu County, Liaoning Province.

[0056] The patient presented to our clinic in March 2001 with symptoms including lower back pain, lumbar spine deformity, fatigue, weight loss, and low-grade fever.

[0057] Physical examination: The patient was conscious, malnourished, and had a blank facial expression. Body temperature was 37.8℃. The patient presented with lumbar deformity, predominantly kyphotic deformity, with significant tenderness and percussion pain at L1-L3 vertebrae. There was no local skin redness or swelling, and movement was limited. X-ray examination revealed extensive bone rupture in L1-L3 vertebral bodies, with sequestrum present. A shadow of approximately 15×15 cm was visible. The X-ray diagnosis was lumbar vertebral tuberculosis and abscess. The patient was then given the following formula (Anti-Bone Tuberculosis Powder, containing: Angelica sinensis 15 parts, Atractylodes macrocephala 10 parts, Codonopsis pilosula 10 parts, Poria cocos 10 parts, Atractylodes lancea 15 parts, Ligusticum striatum 10 parts, Notopterygium incisum 10 parts, Asarum heterotropoides 5 parts, Carthamus tinctorius 10 parts, Polygala tenuifolia 10 parts, Platycodon grandiflorus 10 parts, Saposhnikovia divaricata 5-10 parts, Borneol 0.7 parts, Prunella vulgaris 5 parts, Ligusticum chuanxiong 5 parts, Isomilac 10 parts, Vitamin B6). The patient was treated with 15 doses of a medication, 1.0 gram twice daily with warm water. After 30 days of treatment, the patient's lower back pain was significantly reduced, appetite increased, weight increased, body temperature returned to normal, and the patient was able to get out of bed and move around. The lumbar deformity improved significantly. After one course of treatment (50 days), all the above symptoms disappeared, and the patient was able to move freely and take care of themselves. An X-ray report showed that a large amount of new bone had formed at the site of bone erosion, the abscess had disappeared, and no dead bone was seen. After the second course of treatment, the patient was able to move freely and perform light physical labor in addition to taking care of themselves. After the second course of treatment, a follow-up X-ray was performed, and the report showed no bone erosion, clear and normally arranged trabeculae, and all other aspects were normal. Treatment was stopped for follow-up observation. The patient was able to participate in heavy physical labor without any discomfort. After more than 20 years of follow-up, the patient has not relapsed.

[0058] Case 2

[0059] Patient: Female, 38 years old, residing in Shuangliao City, Jilin Province.

[0060] The patient presented with back pain, thoracic spine deformity, weight loss, loss of appetite, fatigue, and low-grade fever for three years. In July 2002, the patient sought medical treatment at our clinic. Prior to this visit, the patient had been diagnosed with thoracic spine tuberculosis at the Jilin Provincial Tuberculosis Hospital and was hospitalized for treatment. Initially, the treatment focused on conservative anti-tuberculosis therapy, including intravenous isoniazid, PAS (para-aminosalicylic acid sodium), and oral anti-tuberculosis drugs. The details of the medications used are unknown. The treatment was ineffective, and the patient was encouraged to undergo surgery. However, due to financial reasons, the patient did not undergo surgery and came to our clinic for treatment through a relative's recommendation.

[0061] Physical examination: The patient was alert and articulate, with mild anemia and moderate malnutrition. Body temperature was 38.2℃. Deformity was observed in the posterior back, approximately at the T5-T7 vertebral bodies, with significant tenderness and percussion pain. X-rays taken at a higher-level hospital showed extensive bone destruction in the T5-T7 vertebral bodies, with visible necrotic bone and a shadow of approximately 10×10 cm in size at the lesion site. Based on the patient's complaints, physical examination, and the X-ray report from the higher-level hospital, the diagnosis was consistent with thoracic vertebral tuberculosis. The patient was then prescribed this invention (Anti-Bone Tuberculosis Powder, containing: Angelica sinensis 5 parts, Atractylodes macrocephala 3 parts, Codonopsis pilosula 5 parts, Poria cocos 5 parts, Atractylodes lancea 5 parts, Ligusticum striatum 5 parts, Notopterygium incisum 5 parts, Asarum heterotropoides 1 part, Carthamus tinctorius 5 parts, Polygala tenuifolia 3 parts, Platycodon grandiflorus 3 parts, Saposhnikovia divaricata 5 parts, Borneol 0.3 parts, Prunella vulgaris 3 parts, Ligusticum chuanxiong 3 parts). Treatment involved 5 parts of Rifampicin and 10 parts of Vitamin B6, 1.0 gram twice daily, dissolved in warm water. After approximately 30 days of medication, the patient's appetite increased, local pain disappeared, the deformity improved significantly, and body temperature returned to normal. After one course of treatment (50 days), all the aforementioned signs and symptoms had improved. A follow-up X-ray showed extensive new bone formation, no dead bone, abscess resolution, and disappearance of chest deformity. A second course of treatment was followed up, and the X-ray showed that, except for the absence of the aforementioned symptoms and signs, the bone erosion site was well filled with new bone, and the trabeculae were clear and neatly arranged, indicating a complete cure. After more than 20 years of follow-up observation, the patient was able to participate in heavy physical labor, everything was fine, and there was no recurrence.

[0062] Case 3

[0063] Patient: Male, 58 years old, residing in Gongzhuling City, Jilin Province

[0064] The patient presented with redness, swelling, and pain in the right knee joint, resulting in a limp. He had also experienced a high fever for 15 days, which had not responded to local anti-inflammatory and fever-reducing treatments. In March 2004, he sought medical help at our clinic.

[0065] Physical examination: The patient was alert and articulate, but malnourished, with a high fever of 38.8℃. The right knee joint was red and swollen, with fullness in the knee joint eye area, severe pain during movement, and loss of knee flexion function. An X-ray of the right knee revealed a significant bone defect in the tibial plateau, with necrotic bone visible in the eroded area. The diagnosis was right knee joint tuberculosis. The patient was then given the following formula (Anti-Bone Tuberculosis Powder, containing 10 parts Angelica sinensis, 6 parts Atractylodes macrocephala, 8 parts Poria cocos, 10 parts Atractylodes lancea, 8 parts Ligusticum striatum, 2 parts Asarum heterotropoides, 8 parts Carthamus tinctorius, 6 parts Polygala tenuifolia, 8 parts Platycodon grandiflorus, 6 parts Codonopsis pilosula, 6 parts Saposhnikovia divaricata, 0.5 parts Borneol, 4 parts Prunella vulgaris, 4 parts Ligusticum chuanxiong, 8 parts Notopterygium incisum, 8 parts Isomiquercetin, and 10 parts Vitamin B6), 1.0 g twice daily, warm water. The medication was taken orally with water, and joint aspiration was performed simultaneously. Approximately 300 mg of thin, pale yellow pus was extracted, and the smear report indicated tuberculosis infection. On the second day after aspiration, the patient's body temperature dropped to 37°C. After taking this invented drug orally for about 40 days, the redness and swelling of the affected joint disappeared, the body temperature returned to normal, the appetite gradually increased, the pain significantly improved, and the patient was able to walk short distances out of bed. The knee flexion function of the affected joint was restored. After one course of treatment (50 days), all the above symptoms and signs disappeared, and the patient was able to walk long distances without limping. An X-ray report showed that new bone formation had occurred in the eroded area. The second course of treatment was continued, and another X-ray was taken after treatment. The report showed that the eroded area had disappeared, and the trabeculae were neatly arranged. The patient was followed up for about 10 years after stopping the medication, and no recurrence was observed.

[0066] Case 4

[0067] Patient: Male, 38 years old, residing in Xifeng County, Liaoning Province.

[0068] The patient underwent surgery for lumbar tuberculosis at a provincial tuberculosis hospital. After six months of treatment, the tuberculosis recurred. He was temporarily treated with conservative anti-tuberculosis therapy and was preparing for two surgeries. In September 2004, he came to our clinic for treatment through a relative's introduction.

[0069] Physical examination: The patient was conscious, malnourished, and had a normal body temperature. A deformity was observed in the lumbar spine, with significant tenderness and percussion pain at L1-L3. A 20 cm incision scar was visible at the lumbar spine, which had healed primarily. The deformed lumbar vertebrae showed significant kyphosis. Local X-rays were reviewed, revealing partial bone destruction in the L1-L3 vertebral bodies, but no abscess shadows or sequestra were observed. Based on the clinical symptoms, signs, and local X-ray report, lumbar tuberculosis was diagnosed. Postoperative recurrence was treated with this invention (Anti-Bone Tuberculosis Powder), 1.0 g twice daily with warm water. After approximately 30 days of treatment, the above signs and symptoms significantly improved. After one course of treatment (50 days), a follow-up X-ray revealed extensive new bone formation, and the lumbar pain and deformity completely disappeared. A second course of treatment was initiated, and another X-ray showed that the bone tissue at the site of osteonecrosis had returned to normal, with clear and neatly arranged trabeculae. The patient was able to perform heavy physical labor. Follow-up for over 10 years showed no adverse reactions or recurrence.

[0070] Case 5

[0071] Patient: Male, 30 years old, residing in Tongliao City, Inner Mongolia.

[0072] The patient presented with redness, swelling, pain, and limited movement in the right wrist, without chills, fever, or loss of appetite. The local hospital treated it as an infection of the trauma, but there was no significant improvement after two months. The patient then consulted a higher-level hospital in the area, where a diagnosis of bone tuberculosis in the right wrist was made. Conservative anti-tuberculosis treatment was given, but there was no improvement after one month. Surgery was planned, but the patient did not accept it for various reasons. In February 2020, the patient came to our clinic for treatment through the introduction of a relative.

[0073] Physical examination: The patient was alert, spoke normally, was of moderate physical condition, well-nourished, and had a normal body temperature. The patient's right wrist joint was significantly swollen and fusiform, with limited flexion and extension, and marked tenderness. Local X-ray reports showed wrist swelling, blurred joint spaces, and complete decalcification and osteoporosis, particularly noticeable in the carpal bones, exhibiting ice-like destruction, with occasional sequestra. This diagnosis was consistent with wrist tuberculosis. Treatment with this invention (Anti-Bone Tuberculosis Powder) was initiated, 1.0 gram twice daily with warm water. After one course of treatment, the above symptoms and signs significantly improved. Two and three more courses of treatment were subsequently given. All symptoms and signs disappeared. The patient's right wrist regained full flexion and extension, allowing for general physical labor, and grip strength was strong. X-rays showed that the affected bone areas had returned to normal, the boundaries between the carpal bones were clear, and no osteoporotic changes or ice-like destruction were observed. Follow-up for over three years after discontinuation of medication showed no recurrence.

Claims

1. A combination of traditional Chinese and Western medicine for treating bone tuberculosis, characterized in that: The composition comprises the following components by weight: Angelica sinensis 5-15 parts, Atractylodes macrocephala 3-10 parts, Codonopsis pilosula 5-10 parts, Poria cocos 5-10 parts, Atractylodes lancea 5-15 parts, Ligusticum striatum 5-10 parts, Notopterygium incisum 5-10 parts, Asarum heterotropoides 1-5 parts, Carthamus tinctorius 5-10 parts, Polygala tenuifolia 3-10 parts, Platycodon grandiflorus 3-10 parts, Saposhnikovia divaricata 5-10 parts, Borneol 0.3-0.7 parts, Prunella vulgaris 3-5 parts, Ligusticum striatum 3-5 parts, Isomizone 5-10 parts, and Vitamin B6 10-15 parts.

2. The traditional Chinese and Western medicine composition for treating bone tuberculosis according to claim 1, characterized in that: The composition comprises the following ingredients in parts by weight: Angelica sinensis 5 parts, Atractylodes macrocephala 3 parts, Codonopsis pilosula 5 parts, Poria cocos 5 parts, Atractylodes lancea 5 parts, Ligusticum striatum 5 parts, Notopterygium incisum 5 parts, Asarum heterotropoides 1 part, Carthamus tinctorius 5 parts, Polygala tenuifolia 3 parts, Platycodon grandiflorus 3 parts, Saposhnikovia divaricata 5 parts, Borneol 0.3 parts, Prunella vulgaris 3 parts, Ligusticum striatum 3 parts, Isomizone 5 parts, and Vitamin B6 10 parts.

3. The Chinese and Western medicine composition for treating various types of bone tuberculosis as described in claim 1 or 2, and its application in treating various types of bone tuberculosis.

4. A traditional Chinese and Western medicine preparation for treating various types of bone tuberculosis, characterized in that: It is prepared from the formulation of the Chinese and Western medicine composition according to claim 1 or 2.

5. A traditional Chinese and Western medicine composition for treating bone tuberculosis according to claim 4, characterized in that: The dosage form includes powder, tablet, granule or capsule.

6. A traditional Chinese and Western medicine composition for treating bone tuberculosis according to claim 4, characterized in that: S1 Weigh out the following ingredients in proportion: Angelica sinensis, Atractylodes macrocephala, Codonopsis pilosula, Poria cocos, Atractylodes lancea, Ligusticum striatum, Notopterygium incisum, Asarum heterotropoides, Carthamus tinctorius, Polygala tenuifolia, Platycodon grandiflorus, Saposhnikovia divaricata, Borneol, Prunella vulgaris, Ligusticum chuanxiong, Isomilac, and Vitamin B6. Grind them into powder and sieve through a 120-mesh sieve for later use. S2 weighs the obtained bone tuberculosis treatment powder in 1.0 gram portions and packages them into capsules for later use.

7. A traditional Chinese and Western medicine preparation for treating bone tuberculosis according to claim 4, used for the treatment of bone tuberculosis.

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