Thermal response type slow release composition and application thereof

Abstract

The invention provides a thermal response type slow-release composition and application thereof, and belongs to the field of cosmetics or similar dressing preparations. The invention relates to a skin care product which comprises 1, 3-propylene glycol, hydroxy propyl cellulose, isononyl isononanoate, C10-18 fatty acid triglyceride and a freshener. The thermal response type slow-release composition provided by the invention overcomes the defects that the traditional freshener is short in cool feeling lasting time and easy to volatilize and lose; and the coating has good stability, can be well compatible with various application substrates, and is not easy to lose efficacy due to volatilization or migration in the storage and use processes. The thermal response type slow-release composition provided by the invention is a novel freshener which is high in cool feeling strength, long in duration time and stable in application performance, so that the urgent requirements of the fields of high-end textiles, durable daily consumer goods and the like on a long-acting cooling function are met.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of cosmetic or similar toiletry formulations, in particular to a thermally responsive sustained-release composition and its use. BACKGROUND

[0002] With the improvement of people's living standards and the increasing demand for comfort, textiles, personal care products (such as skin care products, shampoos, wet wipes), plastic products, etc. with cooling function are increasingly popular in the market. The core of giving these products a cooling sensation is the addition of a cooling agent ingredient with a cooling sensation. Coolants, or coolants, are a class of chemicals that can activate the cold receptors on the skin and mucous membranes of the human body (such as TRPM8 receptors), triggering a cool, fresh feeling. Traditional coolants, such as menthol and its derivatives (L-menthol, WS-3, WS-23, etc.), menthyl lactate, and certain polyols (such as xylitol), their mechanism of action is mainly through physical or chemical means to bind to the cold receptors, producing a sustained cooling sensation, independent of water evaporation, so the effect is more lasting.

[0003] These traditional coolants have been widely used in many fields. For example, in the textile industry, microencapsulated menthol or WS-23 is attached to the surface of the fiber through a finishing process; in the daily chemical industry, it is directly added to the formula to provide an instant cooling experience when the product is used.

[0004] Although the above traditional coolants have been widely used, they still have some inherent technical defects that need to be solved urgently, mainly focusing on the two aspects of cooling duration and applicability: 1) The intensity and duration of the cooling sensation often follow a fixed pattern, and lack dynamic correlation with changes in environmental temperature or skin surface temperature. When the environmental temperature is high or the skin temperature rises significantly after intense exercise, the fixed cooling release rate may not provide a strong enough cooling feedback to effectively relieve the heat discomfort, resulting in "insufficient cooling".

[0005] 2) The action of traditional coolants is usually direct and single, making it difficult to achieve precise control and programmed release of the cooling effect. Many coolant molecules are small, volatile or migratory, resulting in a short duration of action, and stability problems in the formula system. In order to prolong the duration of action or enhance the initial cooling, it is often necessary to increase the addition concentration or compounding, but this may bring new problems such as increased irritation, rising costs, or poor compatibility with other ingredients.

[0006] 3) Compatibility problems with the substrate: some synthetic coolants may have poor compatibility problems in certain application scenarios (such as in certain plastic or chemical fiber materials), which can easily lead to precipitation, frosting, etc., affecting product appearance and performance. SUMMARY

[0007] Based on the defects existing in the prior art, the present application aims to provide a brand new solution. The primary technical problem to be solved by the present application is to overcome the short-lasting cooling duration and easy loss of volatilization of traditional coolants, and to provide a coolant composition with temperature responsiveness and significantly long-lasting cooling characteristics.

[0008] The first object of the present application is to provide a heat-responsive sustained-release composition comprising at least the following components by mass fraction: 1,3-propanediol 60-70 Hydroxypropyl cellulose 2.0-5.0 isononyl isononanoate 0.5-2.5 C10-18 triglyceride 0.01-0.2.

[0009] Preferably, it further comprises a coolant, which is a component that selectively activates the TRPM8 receptor; the added amount of the coolant is 22.5-36 parts.

[0010] The coolant is a fat-soluble coolant.

[0011] The coolant is at least one of menthane formyl ethylamine, menthol lactate, and methyl diisopropyl propionamide.

[0012] Preferably, the coolant comprises at least the following components by mass fraction: Menthane formyl ethylamine 7.5-12 Menthol lactate 7.5-12 Methyl diisopropyl propionamide 7.5-12.

[0013] The second object of the present application is to provide a preparation method of the aforementioned heat-responsive sustained-release composition, comprising the following steps: S1: Pre-mixing part of the amount of 1,3-propanediol and hydroxypropyl cellulose at ≤35℃ to obtain a pre-mixed solution; S2: Adding the remaining amount of 1,3-propanediol, C10-18 triglyceride, and isononyl isononanoate in a container; heating to ≥85℃ under stirring, and then adding the pre-mixed solution while continuing to stir; After stirring, homogenize, then stir after homogenization; then cool to ≤60℃ to obtain a homogenized material; S3: Adding each coolant in the homogenized material in turn, then stirring, homogenizing, and stirring again; cooling to ≤40℃; filtering and discharging; obtaining a heat-responsive sustained-release composition.

[0014] Preferably, in step S1, the mass ratio of 1,3-propanediol to hydroxypropyl cellulose is 5-20:1.

[0015] Preferably, in the step S2, the stirring rate is ≥ 60 rpm; The homogenization speed is ≥ 1000 rpm; when the homogenization speed is 1000-3000 rpm, the homogenization time is ≥ 30 min; when the homogenization speed is > 3000 rpm, the homogenization time is 10-30 min.

[0016] Preferably, in the step S3, the stirring rate is ≥ 60 rpm, and each stirring time is ≥ 10 min; the homogenization speed is ≥ 1000 rpm; and the homogenization time is ≥ 5 min.

[0017] A third object of the present application is to provide the use of the aforementioned thermally responsive sustained-release composition in the preparation of cosmetic, textile and plastic substrates.

[0018] In the present application, 1,3-propanediol acts as a solvent, humectant, and penetration enhancer; it is used to dissolve other ingredients, provide a refreshing moisturizing feeling, and help active substances penetrate. If this component is missing, the solubility and stability of the present application will be compromised. It may cause HPC to be unable to fully hydrate and thicken, the system is uneven, and it also affects the refreshing degree of skin feel and the penetration of active substances.

[0019] In the present application, hydroxypropyl cellulose (HPC) is a thickening / gel matrix, a sustained-release skeleton, and a stabilizer; it is used to form a gel structure, the viscosity of which may change with temperature, thereby controlling the release rate of ingredients that need to be released (such as cooling agents), and stabilizing the entire system. If hydroxypropyl cellulose is missing, the "thermal response" and "sustained release" functions of the present application will be completely lost. The system cannot form a gel network, WS-23 will be released quickly (without sustained release), and the release speed is no longer regulated by temperature, becoming a simple solution or emulsion.

[0020] In the present application, isononyl isononanoate is a refreshing emollient and a skin feel regulator; its role is to provide a smooth, dry and non-greasy skin feel, and it may help to dissolve and disperse other oily ingredients. If isononyl isononanoate is missing, the skin feel of the present application will be greasy, and there will be compatibility risks. The formula may become thick and greasy, and the oil phase solubility will decrease, which may cause the separation of the ingredients or the roughness of the cream.

[0021] In the present application, C10-18 fatty acid triglycerides act as emollient oils, supplementing skin lipids, and also as a base solvent for oil-soluble ingredients such as cooling agents. If they are missing, the solubility and moisturizing feeling of the present application system will decrease. It may affect the complete dissolution of oil-soluble ingredients (including WS-23), leading to uneven cooling sensation or storage stability problems.

[0022] In the invention, the cooling agent is the core functional ingredient for providing a cooling sensation; in order to build a cooling system with rich levels and better effects, menthane formyl ethylamine (WS-3), menthol lactate and methyl diisopropyl propionamide (WS-23) are compounded, which is based on the following: Complementary sensory properties: the three components have synergistic mechanisms and sensory characteristics. WS-3 can produce a rapid and strong initial cooling sensation; WS-23 provides a strong and pure continuous cooling main body without obvious irritation; menthol lactate acts gently and durably, and can maintain the background cooling after the gradual weakening of the former two. This combination forms a cooling gradient with front, middle and rear stages, making the sensory experience more complete.

[0023] Synergistic and balancing effects: WS-3 and WS-23 enhance each other in cooling intensity, and menthol lactate can alleviate the excessive irritation that may be caused by WS-3. Combined with the heat-responsive slow-release system of the invention, the release rates of the three components can be coordinated, thereby achieving a more stable and long-lasting overall cooling effect. Broadened action spectrum: the above components have different mechanisms of action on human cold receptors, and their combined use can more fully activate related signaling pathways, making the cooling sensation more full and expanding the skin perception area.

[0024] If any component is missing, the synergistic system will have significant sensory defects: Missing WS-3: the initial burst of cooling sensation is weakened, and the impact and recognition in the opening stage are reduced; Missing WS-23: the main intensity and duration of the cooling sensation are reduced, and the middle-stage cooling effect is insufficient; Missing menthol lactate: the maintenance ability of the rear stage of the cooling sensation is weakened, the cooling sensation decays faster, and the overall action time is shortened.

[0025] However, it should be noted that the slow-release matrix provided by the invention can not only carry cooling agents to provide a cooling sensation, but also can encapsulate and control the release of other active ingredients that are beneficial to the skin; such as carrying oat extract to provide soothing and repairing effects; carrying vitamin C derivatives to provide antioxidant and whitening effects; carrying peptides to provide anti-aging effects.

[0026] Overall, the heat-responsive slow-release composition provided by the invention overcomes the shortcomings of traditional cooling agents, such as short cooling duration and easy loss due to volatilization; and has good stability, can be well compatible with various application substrates (such as textile fibers, plastics, skin care product substrates), and is not easy to fail due to volatilization or migration during storage and use. The heat-responsive slow-release composition provided by the invention is a new type of cooling agent with high cooling intensity, long duration and stable application performance, which can meet the urgent needs of high-end textiles, durable daily consumer goods and other fields for long-acting cooling functions.

[0027] Meanwhile, the preparation process of the cooling agent composition is simple, the cost is controllable, and the preparation method is easy for industrial production, the complex microcapsule coating technology is avoided, and the controllable and long-lasting release of the cool feeling is realized. BRIEF DESCRIPTION OF DRAWINGS

[0028] Figure 1 The figure is a one-time cool feeling test figure of the present application example 1 at a concentration of 0.5% and 20 DEG C.

[0029] Figure 2 The figure is a one-time cool feeling test figure of the present application comparative example 4 at a concentration of 0.5% and 20 DEG C.

[0030] Figure 3 The figure is a one-time cool feeling test figure of the present application comparative example 5 at a concentration of 0.5% and 20 DEG C.

[0031] Figure 4 The figure is a one-time cool feeling test figure of the present application comparative example 6 at a concentration of 0.5% and 20 DEG C.

[0032] Figure 5 The figure is a one-time cool feeling test figure of the present application example 1 at a concentration of 0.5% and 30 DEG C.

[0033] Figure 6 The figure is a one-time cool feeling test figure of the present application comparative example 3 at a concentration of 0.5% and 30 DEG C.

[0034] Figure 7 The figure is a transmission electron microscope (TEM) test figure of the present application example 1.

[0035] Figure 8 The figure is a two-time cool feeling test figure of the present application example 1 at a concentration of 0.5% and 20 DEG C.

[0036] Figure 9 The figure is a two-time cool feeling test figure of the present application comparative example 8 at a concentration of 0.5% and 20 DEG C.

[0037] Figure 10 The figure is an appearance picture of the present application example 1; the left side is a state at 25±2 DEG C, and the right side is a state at 35±2 DEG C.

[0038] Figure 11 The figure is an appearance picture of the present application comparative example 1 at 25±2 DEG C; Figure 12 The figure is an appearance picture of the present application comparative example 2 at 25±2 DEG C; Figure 13 The figure is an appearance state picture of the present application premix liquid; the left side is example 1, and the right side is comparative example 7. DETAILED DESCRIPTION

[0039] The technical solutions in the embodiments of the present application will be clearly and completely described below. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative work fall within the protection scope of the present application.

[0040] The experimental methods used in the specific embodiments are conventional methods without special instructions, and the materials, reagents and the like used are commercially available without special instructions.

[0041] In the present application, unless otherwise specified, "%" represents mass percentage; the raw materials, reagents and the like used are conventional commercially available products.

[0042] The components used in the present application are shown in Table 1 as follows: Table 1 Component composition table

[0043] Example 1: The composition ratio is as follows: 71.49 wt% of 1,3-propanediol, 8 wt% of methyldiisopropylpropionamide, 8 wt% of menthane formyl ethylamine, 8% of menthol lactate, 3.5 wt% of hydroxypropyl cellulose, 1 wt% of isononyl isononanoate, 0.01% of C10-18 fatty acid triglyceride.

[0044] The preparation method is as follows: S1: premix 70 wt% of 1,3-propanediol and all hydroxypropyl cellulose at ≤35℃ to obtain a premix liquid; S2: add the remaining amount of 1,3-propanediol, C10-18 fatty acid triglyceride and isononyl isononanoate in an emulsifying kettle; heat to 85℃ under stirring at 60 rpm, and keep the temperature; Then add the premix liquid and continue stirring at 60 rpm for 1h; After stirring, homogenize at 1000 rpm for 30 min, then stir at 60 rpm for 10 min after homogenization; then cool to ≤60℃ to obtain a homogenized material; S3: add methyldiisopropylpropionamide, menthane formyl ethylamine and menthol lactate in the homogenized material in sequence, then stir at 60 rpm for 10 min, homogenize at 1000 rpm for 5 min, and then stir at 60 rpm for 10 min; cool to ≤40℃; filter through gauze, and then discharge; fill to obtain a thermal response type sustained release composition.

[0045] Example 2: The composition ratio is as follows: 65.49 wt% of 1,3-propanediol, 10 wt% of methyl diisopropylpropionamide, 10 wt% of menthane formyl ethylamine, 10% of menthol lactate, 3.5 wt% of hydroxypropyl cellulose, 1 wt% of isononyl isononanoate, 0.01% of C10-18 fatty acid triglycerides.

[0046] S1: 17.5 wt% of 1,3-propanediol and all hydroxypropyl cellulose are premixed at ≤35°C to obtain a premix; S2: The remaining amount of 1,3-propanediol, C10-18 fatty acid triglycerides, and isononyl isononanoate are added in an emulsifying kettle; heated to 85°C with stirring at 60 rpm, and kept at this temperature; Then the premix is added, and stirring is continued at 60 rpm for 2h; After stirring, homogenization is performed at 3000 rpm for 10 min, and then stirring is performed at 60 rpm for 10 min after homogenization; then the temperature is lowered to ≤60°C to obtain a homogenized material; S3: Methyl diisopropylpropionamide, menthane formyl ethylamine, and menthol lactate are sequentially added to the homogenized material, and then stirring is performed at 60 rpm for 10 min, homogenization is performed at 1000 rpm for 5 min, and then stirring is performed at 60 rpm for 10 min; the temperature is lowered to ≤40°C; after filtration through gauze, the product is discharged; and filling is performed to obtain a thermal response type sustained release composition.

[0047] Example 3: The composition ratio is as follows: 70.3 wt% of 1,3-propanediol, 8 wt% of methyl diisopropylpropionamide, 8 wt% of menthane formyl ethylamine, 8% of menthol lactate, 3.5 wt% of hydroxypropyl cellulose, 2 wt% of isononyl isononanoate, 0.2% of C10-18 fatty acid triglycerides.

[0048] The preparation process is the same as that in Example 1.

[0049] Comparative Example 1 Hydroxypropyl cellulose is omitted from the composition ingredients, and the preparation process is the same as that in Example 1.

[0050] Comparative Example 2 Isononyl isononanoate is omitted from the composition ingredients, and the preparation process is the same as that in Example 1.

[0051] Comparative Example 3 C10-18 fatty acid triglycerides are omitted from the composition ingredients, and the preparation process is the same as that in Example 1.

[0052] Comparative Example 4 Methyl diisopropylpropionamide is omitted from the composition ingredients, and the preparation process is the same as that in Example 1.

[0053] Comparative Example 5 Example 1 was repeated, except that menthane carboxamide was omitted.

[0054] Comparative Example 6 Example 1 was repeated, except that menthol lactate was omitted.

[0055] Comparative Example 7 Example 1 was repeated, except that the temperature of the premix of 1,3-propanediol and hydroxypropyl cellulose was adjusted to 55°C.

[0056] Comparative Example 8 Example 1 was repeated, except that the composition comprised 76 wt% 1,3-propanediol, 8 wt% methyl diisopropylpropionamide, 8 wt% menthane carboxamide, and 8% menthol lactate.

[0057] Test Example 1: One-time cooling sensation test Test area temperature: 20°C Volunteers who met the conditions were selected to participate in the test. The test area was the inner side of the left and right forearm. After applying the test sample, no water or water stimulation was added, and the sensory nerve quantitative instrument was measured by electrical stimulation method at the corresponding time point. 5 Hz mainly stimulates non-myelinated C fibers, mainly for pain, slow pain, temperature and postganglionic sympathetic nerves; 250 Hz mainly stimulates A fibers, mainly for mechanical receptors, pressure, temperature and fast pain; 2000 Hz mainly stimulates A fibers, mainly for skin touch pressure. Therefore, this test was set to measure the change of human temperature sensation after using different amounts of samples at 5 Hz. The lower the temperature sensation, the higher the signal.

[0058] Test area: inner side of left and right forearm.

[0059] Sample usage: During the test period, the test area was randomly selected by the staff according to the random table.

[0060] Test procedure: ① Volunteer screening: information registration, informed consent ② Apply the sample.

[0061] ③ Sensory nerve quantitative detection instrument electrical stimulation measurement: After applying the sample, apply the coupling agent, and detect the minimum electrical stimulation intensity change value at the corresponding time point.

[0062] Test period: 1 day.

[0063] Test time points: Before applying the sample, 0 min, 5 min, 10 min, 20 min, 30 min, 60 min, 90 min, and 120 min after applying the sample.

[0064] The test sample was prepared as a 0.5% aqueous solution and then tested.

[0065] The results of Example 1 are as follows Figure 1 As shown; the results of Comparative Example 4 are as follows. Figure 2 As shown; the results of Comparative Example 5 are as follows. Figure 3 As shown; the results of Comparative Example 6 are as follows. Figure 4 As shown.

[0066] As shown in the figure, Example 1 produced a prolonged cooling sensation throughout the 0-90 min period. In Comparative Example 4, the cooling sensation weakened in the middle stage (10-60 min), and the overall cooling sensation was less intense than in Example 1. In Comparative Example 5, the cooling sensation was weak in the later stage (30-120 min), and the overall cooling sensation was less intense than in Example 1. In Comparative Example 6, the cooling sensation was significantly weakened in the early stage (0-20 min).

[0067] Test Example 2: One instance of cooling sensation (30 degrees Celsius) Test area temperature: 30℃ Other tests remain unchanged from test ①.

[0068] The results of Example 1 are as follows Figure 5 As shown; the results of Comparative Example 3 are as follows. Figure 6 As shown, the cooling effect of Example 1 is enhanced after the ambient temperature is increased, and the surface test sample exhibits an enhanced cooling effect after high temperature. Comparative Example 3 does not show a temperature-responsive effect.

[0069] The high-temperature thermal response principle of this invention is as follows: the composition structure contains an oil phase core composed of a specific ratio of isononyl isononanoate and C10-18 fatty acid triglycerides (such as... Figure 7 The oil phase core undergoes changes in its oil phase morphology at different temperatures (mainly the solidification and liquefaction of oils), thus altering the morphology of the encapsulated components under different temperature conditions and affecting the release of its cooling ingredients. At higher temperatures, the oil phase core increases in volume, allowing for faster release of its encapsulated components after application to the skin. Therefore, the cooling sensation is enhanced at higher temperatures.

[0070] Test Example 3: Second Cooling Test Secondary Cooling Sensation Assessment using the Current Perception Threshold (CPTCPT) Test area: the inner side of the forearms of both arms.

[0071] Test area temperature: 20℃ Sample application method: During the testing period, staff will apply the test sample to the corresponding test area according to the random table.

[0072] Test process: 1) Volunteer screening: Registration of enrollment information and informed consent 2) Smear sample.

[0073] 3) Sensory nerve quantitative detector electric stimulation test: after smearing the sample, couple the agent, and detect the minimum electric stimulation intensity change value at the corresponding time point.

[0074] 4) Secondary cool feeling stimulation test: at the test time point, use non-woven fabric to absorb water for 5s, after the water evaporates, couple the agent to detect the minimum electric stimulation intensity change value.

[0075] Test period: 1 day.

[0076] Test time points: Before smearing the sample, 0min, 15min, 30min, 60min after smearing the sample, immediately after contacting water, 15min, 30min, 60min after contacting water.

[0077] The test sample is configured into a 0.5% concentration aqueous solution for testing.

[0078] The results of Example 1 are shown in Figure 8 The results of Comparative Example 8 are shown in Figure 9 It can be seen that Comparative Example 8 does not have secondary cool feeling; Example 1 has obvious secondary cool feeling and has the effect of secondary cool feeling release.

[0079] Test Example Four: Appearance difference comparison between Example and Comparative Example Figure 10 The left side is the state at 25±2℃, and the right side is the state at 35±2℃. It can be seen that at 25±2℃, Example 1 is a slightly hazy solution; at 35±2℃, Example 1 is a hazy solution that is less transparent.

[0080] Figure 11 It is the appearance picture of Comparative Example 1 of the present application at 25±2℃; it can be seen that the wrapping system of hydroxypropyl cellulose is missing in the composition, and the oil component floats above the complex.

[0081] Figure 12 It is the appearance picture of Comparative Example 2 of the present application at 25±2℃; it can be seen that isononyl isononanoate is missing in the composition, and C10-18 fatty acid triglycerides cannot be uniformly dispersed in the propylene glycol system.

[0082] Figure 13 It is the appearance picture of the premix solution of the present application; the left side is Example 1, and the right side is Comparative Example 7. It can be seen that the cellulose pre-solution state of Example 1 is uniform after low-temperature premixing, and there are no large particles. After high-temperature premixing of Comparative Example 7, semi-transparent particles appear in the premix solution, which affects the subsequent preparation process, and it is easy to produce opaque particles during production, which easily blocks the discharge filter screen during discharge, affecting the efficiency of scale-up production.

[0083] Finally, it should be noted that the above examples are only used to illustrate the technical solutions of the present application, and are not intended to limit the same; although the present application has been described in detail with reference to the foregoing examples, those of ordinary skill in the art should understand that they can still modify the technical solutions recorded in the foregoing examples, or make equivalent replacements for part of the technical features; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the spirit and scope of the technical solutions of the embodiments of the present application.

Claims

1. A thermo-responsive sustained-release composition, characterized in that, It includes at least the following components, calculated by parts by weight: 1,3-Propanediol 60-70 Hydroxypropyl cellulose 2.0-5.0 Isonononyl isononanoate 0.5-2.5 C10-18 fatty acid triglycerides 0.01-0.

2.

2. The thermoresponsive sustained-release composition according to claim 1, characterized in that, It also includes a cooling agent component, which is a component that selectively activates the TRPM8 receptor; the amount of the cooling agent added is 22.5-36 parts.

3. The thermoresponsive sustained-release composition according to claim 2, characterized in that, The cooling agent is a fat-soluble cooling agent.

4. The thermoresponsive sustained-release composition according to claim 2, characterized in that, The cooling agent is at least one of menthol carbamoyl ethylamine, menthol lactate, and methyl diisopropyl propionamide.

5. The thermoresponsive sustained-release composition according to claim 4, characterized in that, The cooling agent, when calculated by weight, includes at least the following components: Menthyl carbamoyl ethylamine 7.5-12 Menthol lactate 7.5-12 Methyl diisopropyl propionamide 7.5-12.

6. A method for preparing the thermoresponsive sustained-release composition according to any one of claims 1-5, characterized in that, Includes the following steps: S1: Premix a portion of 1,3-propanediol and hydroxypropyl cellulose at ≤35°C to obtain a premixed solution; S2: Add the remaining 1,3-propanediol, C10-18 fatty acid triglycerides and isononyl isononanoate to the container; heat to ≥85°C while stirring, and keep warm; then add the premix and continue stirring. After stirring, homogenize, then stir again; then cool to ≤60℃ to obtain a homogenized material; S3: Add each cooling agent sequentially to the homogenized material, then stir, homogenize, and stir again; cool to ≤40℃; filter and discharge; obtain a heat-responsive sustained-release composition.

7. The method for preparing the thermo-responsive sustained-release composition according to claim 6, characterized in that, In step S1, the mass ratio of 1,3-propanediol to hydroxypropyl cellulose is 5-20:

1.

8. The method for preparing the thermo-responsive sustained-release composition according to claim 6, characterized in that, In step S2, the stirring rate is ≥60 rpm; The homogenization speed is ≥1000 rpm; when the homogenization speed is 1000-3000 rpm, the homogenization time is ≥30 min; when the homogenization speed is >3000 rpm, the homogenization time is 10-30 min.

9. The method for preparing the thermoresponsive sustained-release composition according to claim 6, characterized in that, In step S3, the stirring rate is ≥60 rpm, and the stirring time is ≥10 min each time; The homogenization speed is ≥1000 rpm; the homogenization time is ≥5 min.

10. The use of the thermoresponsive sustained-release composition according to any one of claims 1-5 in the preparation of cosmetics, textiles and plastic substrates.

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