Method and device for sensing, detecting and analyzing oxygen concentration of implantable abdominal cavity

Abstract

The invention discloses a method and a device for sensing, detecting and analyzing oxygen concentration of an implantable abdominal cavity, and belongs to the field of implantable abdominal cavity detection. The device comprises an external heat shrink tube, a parameter detection circuit, an oxygen detection light path, a coupling electrode and a battery, the oxygen detection light path comprises a reflective metal film, an oxygen sensitive film and a polyethylene terephthalate sheet; the parameter detection circuit comprises a main control unit, a parameter measurement module, a magnetic control switch, a communication module and a power management unit; after the oxygen sensitive film is in contact with oxygen, internal phosphorescence molecules are combined with oxygen molecules, molecular oxygen interacts with luminous molecules to cause phosphorescence quenching, so that the light intensity is reduced, light source excitation and photoelectric conversion are performed on the phosphorescence through the parameter detection circuit, the light intensity is converted into an electric signal, and the oxygen concentration is detected. According to the method, the parameters in the abdominal cavity can be quantified, and a platform is provided for objective evaluation of physical environment changes in the abdominal cavity and in-vivo long-term low-power-consumption detection.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of implantable abdominal cavity detection, in particular to a method and device for implantable abdominal cavity oxygen concentration sensing detection analysis. BACKGROUND

[0002] Implantable detection has important application potential in the field of human health. In the field of critical care medicine and major abdominal surgery, precise and continuous monitoring of the patient's abdominal cavity environment is the key to determining the success or failure of clinical prognosis. Fatal complications such as abdominal compartment syndrome, occult intestinal ischemia and abdominal infection often develop rapidly and are hidden. Traditional monitoring methods, such as intermittent intra-abdominal pressure measurement, body surface temperature, serum lactate and imaging examination, have inherent limitations such as time lag, data dispersion and difficulty in reflecting the true state of deep tissues, which often lead to clinical decision-making based on "passive reaction" rather than "active warning", seriously hindering the improvement of successful rescue rate. In contrast, implantable microsensors can achieve continuous and accurate monitoring of key physiological parameters in the digestive tract by placing a miniature sensing unit in the body. Such devices are small in size, low in power consumption, and can be used with portable receivers or smartphones, greatly improving the convenience of use and patient compliance.

[0003] The main problems existing in the existing implantable detection device are as follows:

[0004] 1. Poor reception signal quality

[0005] Most traditional implantable detection devices use Bluetooth transmission, and the signal frequency band of about 2GHz has an absorption effect in human tissue, resulting in poor transmission signal quality. At the same time, the Bluetooth chip increases the size of the detection circuit, further increasing the overall system size.

[0006] 2. High device power consumption

[0007] In order to reduce the size of the device, a small capacity battery is generally used for power supply, and a Bluetooth or radio frequency system is used for communication. The power consumption of traditional implantable devices is in the order of mA, which makes it impossible for the device to perform long-term or full-process detection.

[0008] 3. Large size of sensing device

[0009] Implantable devices usually use electrochemical methods to collect oxygen concentration. At the same time, the required current consumption is large, and a gas chamber containing solvent is needed to build an oxygen sensor, resulting in an increase in the overall size. SUMMARY

[0010] In view of the deficiencies of the prior art, the purpose of the present application is to provide a method and device for implantable abdominal cavity oxygen concentration sensing detection analysis.

[0011] In order to achieve the above object, the present application adopts the following technical scheme: a device for implantable abdominal cavity oxygen concentration sensing, detection and analysis, comprising: an external heat shrink tube, a parameter detection circuit, an oxygen detection light path, a coupling electrode and a battery;

[0012] The oxygen detection light path is arranged on the parameter detection circuit, and the parameter detection circuit is connected with the coupling electrode and the battery, and the entire device is wrapped in the external heat shrink tube;

[0013] The oxygen detection light path comprises a reflective metal film, an oxygen sensitive film and a polyester substrate, the oxygen sensitive film is arranged on the polyester substrate, and the reflective metal film covers the oxygen sensitive film; after the oxygen sensitive film contacts oxygen, internal phosphor molecules combine with oxygen molecules, and the interaction between molecular oxygen and light-emitting molecules causes phosphorescence quenching, thereby reducing light intensity; the parameter detection circuit excites and photoelectrically converts the light source of the oxygen detection light path, converts the light intensity into an electrical signal, and realizes detection of the oxygen concentration.

[0014] Further, the parameter detection circuit comprises:

[0015] A master control unit for controlling the parameter detection circuit to start detection, setting a carrier frequency communication signal frequency and data calculation and analysis;

[0016] A parameter measurement module for detecting an oxygen concentration signal through analog or digital conversion;

[0017] A magnetic control switch for stopping power supply in an unused state of the device;

[0018] A communication module for on-off keying communication signal and measurement signal coding;

[0019] A power management unit for providing stable working voltage for the communication module and the parameter measurement module.

[0020] Further, the master control unit is a minimum single-chip system, connected with the parameter measurement module through an analog or digital bus, sets a detection frequency, reads data sent by the parameter measurement module, processes and calibrates the data, obtains an oxygen concentration corresponding voltage value, and obtains an oxygen concentration value according to the voltage value and formula processing; the master control unit is connected with the communication module, and sends a 6M carrier frequency signal obtained by frequency multiplication and detection data to the communication module.

[0021] Further, the communication module is a minimum sn74aup1g57 system, and the 6M carrier frequency signal and the detection data are formed into on-off keying coding signals in the form of exclusive or logic.

[0022] Further, the parameter measurement module comprises a minimum system of an operational amplifier, an excitation light source, a photoreception diode and a filter, and the oxygen-sensitive film is excited by phosphorescence and voltage signal detection through the excitation light source, the photoreception diode and the filter.

[0023] Further, the oxygen detection light path comprises a support structure, the polyester substrate is an ethylene glycol terephthalate sheet, and the reflective metal film is a porous aluminum foil arranged at the bottom end of the support structure.

[0024] Further, the oxygen-sensitive film is prepared by the following method:

[0025] A mixture of acetone and 1,2-dichloroethane in a volume ratio of 1:3 is prepared;

[0026] Poly (methyl methacrylate) is added to the mixture and completely dissolved at room temperature;

[0027] Platinum octaethyl porphyrin is added, and after sufficient stirring, coumarin 545T is added and continues to be stirred;

[0028] The prepared solution is drop-coated on the ethylene glycol terephthalate sheet, and the oxygen-sensitive film is obtained by curing at room temperature.

[0029] Further, the coupling electrode is a group of copper foil co-type coupling antennas.

[0030] Further, the device is embedded with a program for writing a long-term detection system, specifically, the parameter detection circuit is in a low-power mode for a long time, wakes up once every 10 seconds, performs environmental monitoring and updates data for transmission.

[0031] The application also provides a method for implantable abdominal cavity oxygen concentration sensing detection and analysis, comprising the following steps:

[0032] A mixture of acetone and 1,2-dichloroethane in a volume ratio of 1:3 is prepared; poly (methyl methacrylate) is added to the mixture and completely dissolved at room temperature; platinum octaethyl porphyrin is added, and after sufficient stirring, coumarin 545T is added and continues to be stirred; the prepared solution is drop-coated on the ethylene glycol terephthalate sheet, and the oxygen-sensitive film is obtained by curing at room temperature.

[0033] The oxygen-sensitive film and the ethylene glycol terephthalate sheet are covered with a reflective metal film to obtain an oxygen detection light path;

[0034] The oxygen detection light path is arranged on the parameter detection circuit, and the parameter detection circuit is connected with the coupling electrode and the battery, and is wrapped in an external heat shrink tube to obtain a detection device.

[0035] The detection device is arranged in the abdominal cavity of the target to be detected, oxygen in the abdominal cavity enters the oxygen detection light path through the external heat shrink tube, the light intensity of the oxygen sensitive film changes after receiving the oxygen signal, the light intensity signal is excited and converted into a voltage signal by the excitation light and the photodiode of the parameter detection circuit, and the oxygen concentration detection is realized.

[0036] The present application has the following advantages:

[0037] 1. In the oxygen concentration detection aspect, the oxygen sensitive film is integrated in the reflective light path, realizing low-cost and small-size oxygen detection. The volume of the light path and the detection circuit is greatly reduced to 1cm 3 .

[0038] 2. In the signal transmission aspect, the signal is transmitted in the on-off keying form through the human body tissue as the medium by the design of the co-type coupling antenna, realizing a simpler signal transmission method, and reducing the required volume of the communication device.

[0039] 3. In the power consumption reduction aspect, the average power is reduced to the level of 50 mu A by using the co-type coupling antenna combined with the low-power software design, and the detection duration of the device is improved. DETAILED DESCRIPTION

[0040] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed in the embodiment description will be briefly introduced. Obviously, the drawings in the following description are only some embodiments of the present application, and other drawings can be obtained by those skilled in the art without creative labor.

[0041] Figure 1 It is a exploded view of the device of the present application;

[0042] Figure 2 It is a structure diagram of the parameter detection circuit of the present application;

[0043] Figure 3 It is an exploded view of the oxygen detection light path of the present application;

[0044] Figure 4 It is a flow chart of preparing the oxygen sensitive film of the present application;

[0045] Figure 5 It is a table of oxygen sensing film, excitation light source and filter absorption spectrum and emission spectrum characterization of the present application;

[0046] Figure 6 It is a calibration curve diagram of oxygen concentration and light intensity response of the present application;

[0047] Figure 7 It is a on-off keying modulation principle diagram of the present application;

[0048] Figure 8 Modulated signal diagram for the coupling antenna transmission of the present application;

[0049] Figure 9 Flow chart for low power consumption software writing for the device of the present application;

[0050] Figure 10 Power consumption waveform diagram for the device of the present application;

[0051] Figure 11 Schematic diagram of oxygen concentration change trend detected by the gastrointestinal device of the present application;

[0052] Figure 12 Schematic diagram of oxygen concentration change trend in the abdominal cavity of a rat induced by low concentration lipopolysaccharide;

[0053] Figure 13 Schematic diagram of oxygen concentration change trend in the abdominal cavity of a rat induced by high concentration lipopolysaccharide;

[0054] In the figure: 100, external heat shrink tube, 200, parameter detection circuit, 300, oxygen detection light path, 400, coupling electrode, 500, battery, 301, reflective metal film, 302, oxygen sensitive film, 303, polyester substrate. DETAILED DESCRIPTION

[0055] The present application will be further described below through specific embodiments.

[0056] In the present application, the directions or positional relationships indicated by "up", "down", "left", "right", "front" and "back" are based on the directions or positional relationships shown in the drawings, and are only for the convenience of describing the present application, and do not indicate or imply that the device must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as limiting the scope of protection of the present application. For those skilled in the art, the specific meanings of the above terms in the present application can be understood according to the specific circumstances.

[0057] In addition, in the description of the present application, "multiple" means two or more, unless otherwise specified. The association relationship between the associated objects is described as "and / or", which means that there can be three relationships, for example, A and / or B can mean that A exists alone, A and B exist together, and B exists alone. The character " / " generally represents a "or" relationship between the associated objects before and after it.

[0058] As shown in Figure 1 The embodiment of the present application provides a device for implantable abdominal cavity oxygen concentration sensing detection and analysis, which comprises an external heat shrink tube 100, a parameter detection circuit 200, an oxygen detection light path 300, a coupling electrode 400 and a battery 500.

[0059] The oxygen detection optical path 300 is set on the parameter detection circuit 200. The parameter detection circuit 200 is connected to the coupling electrode 400 and the battery 500. The entire device is wrapped in an external heat shrink tubing 100.

[0060] Among them, such as Figure 3 As shown, the oxygen detection optical path 300 includes a reflective metal film 301, an oxygen-sensitive film 302, and a polyester substrate 303. The oxygen-sensitive film 302 is disposed on the polyester substrate 303, and the reflective metal film 301 covers the oxygen-sensitive film 302. When the oxygen-sensitive film 302 comes into contact with oxygen, the phosphorescent molecules inside combine with the oxygen molecules. The interaction between the molecular oxygen and the luminescent molecules causes phosphorescence quenching, thereby reducing the light intensity. The parameter detection circuit 200 excites the oxygen detection optical path 300 and performs photoelectric conversion, converting the light intensity into an electrical signal to realize the detection of oxygen concentration.

[0061] The external heat shrink tubing 100 is made of G•APEX MT2-0064 medical material; the coupling electrode 400 is a set of copper foil conformal coupling antennas.

[0062] As a preferred embodiment, such as Figure 2 As shown, the parameter detection circuit 200 includes:

[0063] The main control unit is used to control the parameter detection circuit 200 to start detection, set the carrier frequency communication signal frequency, and perform data calculation and analysis.

[0064] The parameter measurement module is used to detect oxygen concentration signals through analog or digital conversion.

[0065] A magnetic switch is used to stop the power supply to the device when it is not in use.

[0066] The communication module is used for encoding the on / off key control communication signals and measurement signals.

[0067] The power management unit provides a stable operating voltage for the communication module and the parameter measurement module.

[0068] The main control unit includes an MSP430 microcontroller and its minimum system; the parameter measurement module includes a minimum system consisting of a MAX9911 operational amplifier, an excitation light source XL0603BC440, and a photodiode NJL6401R; the measurement and control switch and communication module are sn74aup1g57 minimum systems; and the power management unit includes a linear regulator TPS63901 and its peripheral circuitry.

[0069] Preferably, the main control unit is connected to the parameter measurement module via an analog or digital bus, sets the detection frequency, reads the data sent by the parameter measurement module, processes and calibrates the data to obtain the voltage value corresponding to the oxygen concentration, and processes the voltage value and formula to obtain the oxygen concentration value. The main control unit is connected to the communication module, sending the 6M carrier frequency signal obtained by frequency doubling and the detection data to the communication module. The communication module forms an on / off keying code signal by using a XOR logic form between the 6M carrier frequency signal and the detection data. The oxygen-sensitive film 302 is phosphorescently excited and the voltage signal is detected by an excitation light source, a photodiode, and a filter.

[0070] In a preferred embodiment, the oxygen detection optical path 300 includes a support structure, and the reflective metal film 301 is a porous aluminum foil disposed at the bottom of the support structure.

[0071] Furthermore, such as Figure 4 As shown, the oxygen-sensitive film 302 is prepared as follows: First, a mixture of 2 mL acetone and 1,2-dichloroethane (volume ratio 1:3) is prepared. Then, 0.3 g of polymethyl methacrylate is added to the mixture, and it is stirred at room temperature in a magnetic stirrer until completely dissolved. Next, 6.05 mg of platinum octaethylporphyrin (PtOEP) is added, and the mixture is stirred for 30 minutes. Afterward, 10.54 mg of coumarin 545T (c545T) is added, and the solution is stirred for another 30 minutes. The prepared solution is then drop-coated onto a polyethylene terephthalate sheet, covering the porous aluminum foil.

[0072] As a preferred embodiment, the absorption and emission spectra of the prepared oxygen-sensitive thin film 302, excitation light source, and filter are as follows: Figure 5 As shown, the absorption peak of the oxygen-sensitive film 302 is near the emission peak of the excitation source, and the emission spectrum of the oxygen-sensitive film 302 under the action of excitation light is near the absorption peak of the filter.

[0073] The calibration curve of the light intensity of the oxygen-sensitive film 302 as a function of the oxygen concentration in the environment is shown below. Figure 6 As shown.

[0074] In a preferred embodiment, the device implements on / off keying modulation at a frequency of 6 MHz. This special on / off keying signal is achieved by the main control module in conjunction with the communication module by inverting the carrier phase; the in-phase state represents 0, and the out-of-phase state represents 1. This differential signal can increase the transmission amplitude to twice the power supply voltage, thereby increasing the energy coupled to the human body. Figure 7 As shown, the signal is modulated together with the 6MHz carrier signal using an XOR gate to achieve data transmission at the transmitting end. The actual modulation signal diagram of the coupled antenna is shown in the figure below. Figure 8 As shown.

[0075] As a preferred embodiment, the device is embedded with a software programming system to realize the long-term detection method, as shown in the following figure. Figure 9 As shown in the software programming framework of the foreground and background logic, the MSP430 system is set in the low-power mode 3, and the parameter detection circuit 200 is woken up every 10 seconds to monitor the environment and update the data for transmission.

[0076] The actual power consumption of the device is shown in the following figure. Figure 10 As shown in the figure, the current in the resting state is 40 mu A, and the data acquisition and calculation can be completed within 2 milliseconds, and the average current is 2 mA.

[0077] The embodiment of the application also provides a method for implantable abdominal cavity oxygen concentration sensing detection and analysis, comprising the following steps:

[0078] A mixture of acetone and 1,2-dichloroethane in a volume ratio of 1:3 is prepared; poly(methyl methacrylate) is added to the mixture and completely dissolved at room temperature; platinum octaethyl porphyrin is added, and after sufficient stirring, coumarin 545T is added and continues to be stirred; the prepared solution is drop-coated on an ethylene glycol phthalate sheet, and is cured at room temperature to obtain an oxygen-sensitive thin film 302.

[0079] The oxygen-sensitive thin film 302 is arranged on the ethylene glycol phthalate sheet, and a reflective metal film 301 is used to cover it, to obtain an oxygen detection light path 300.

[0080] The oxygen detection light path 300 is arranged on the parameter detection circuit 200, and the parameter detection circuit 200 is connected with the coupling electrode 400 and the battery 500, and is wrapped in the external heat shrink tube 100, to obtain a detection device.

[0081] The detection device is arranged in the abdominal cavity of the target to be measured, and the oxygen in the abdominal cavity enters the oxygen detection light path 300 in the device through the external heat shrink tube 100, the oxygen-sensitive thin film 302 changes in light intensity after receiving the oxygen signal, and the light intensity signal is excited and converted into a voltage signal by the excitation light and the photodiode in the parameter detection circuit 200, to realize oxygen concentration detection.

[0082] As a preferred embodiment, the following experiments are carried out based on the device of the application, and the experiments are specifically as follows:

[0083] New Zealand rabbits are used as in-vivo evaluation experimental animals of the device, and the device is sent into the gastrointestinal tract of the New Zealand rabbit from the oral cavity, and the oxygen concentration signal detected by the device is as shown in the following figure. Figure 11As shown, oxygen levels did not decrease significantly in the upper digestive tract. Around 3:00 PM, the oxygen concentration began to decrease slowly and steadily. In the small intestine, this decrease was almost uniform until it fell below 5%. Microbial fermentation gradually consumed the oxygen in the intestinal contents, and as the intestines extended, the oxygen content gradually decreased, reaching a near-anaerobic environment in the colon and rectum.

[0084] Intraperitoneal injection of LPS (lipopolysaccharide) is a standardized method for inducing inflammation in experimental studies, mainly used to establish acute or chronic inflammation models in rodents (such as rats).

[0085] like Figure 13 The figure shows the results of peritoneal environment detection after induction with 0.6 mg low-concentration LPS. The device was implanted into the peritoneal cavity of rats, and 0.6 mg of low-concentration LPS was injected into the peritoneal cavity. The data in the peritoneal cavity of the rats were observed. As can be seen from the figure, the oxygen concentration decreased, and this state began to recover after about 6 hours, with the oxygen concentration gradually increasing.

[0086] like Figure 12 The image shows the results of peritoneal environment detection after induction with 3mg high-concentration LPS. The device was implanted into the peritoneal cavity of rats, and 3mg of high-concentration LPS was injected into the peritoneal cavity. The data in the peritoneal cavity of the rats were observed. The results showed that the oxygen concentration of the rats decreased continuously after injection, down to about 5%.

[0087] The method and device for implantable peritoneal oxygen concentration sensing and analysis of the present invention can realize low-power miniaturized detection of in vivo oxygen concentration in the digestive tract, quantify various physiological reactions in the peritoneal cavity, and provide a powerful platform for objectively assessing changes in the physical environment of the peritoneal cavity. It can be applied to various application scenarios such as clinical prognosis monitoring, research on the dynamic evolution of peritoneal pathophysiology in critical illness, and postoperative monitoring after organ transplantation, realizing a shift from "passive response" to "active early warning".

[0088] The above are merely specific embodiments of the present invention, but the design concept of the present invention is not limited thereto. Any non-substantial modifications made to the present invention using this concept shall be considered as infringing upon the protection scope of the present invention.

Claims

1. A device for implantable peritoneal oxygen concentration sensing and analysis, characterized in that, include: External heat shrink tubing (100), parameter detection circuit (200), oxygen detection optical path (300), coupling electrode (400), and battery (500); The oxygen detection optical path (300) is set on the parameter detection circuit (200), the parameter detection circuit (200) is connected to the coupling electrode (400) and the battery (500), and the entire device is wrapped in an external heat shrink tubing (100); The oxygen detection optical path (300) includes a reflective metal film (301), an oxygen-sensitive film (302), and a polyester substrate (303). The oxygen-sensitive film (302) is disposed on the polyester substrate (303), and the reflective metal film (301) covers the oxygen-sensitive film (302). When the oxygen-sensitive film (302) comes into contact with oxygen, the phosphorescent molecules inside combine with the oxygen molecules. The interaction between the molecular oxygen and the luminescent molecules causes phosphorescence quenching, thereby reducing the light intensity. The oxygen detection optical path (300) is excited by the light source and photoelectric conversion by the parameter detection circuit (200) to convert the light intensity into an electrical signal to realize the detection of oxygen concentration.

2. The apparatus according to claim 1, characterized in that, The parameter detection circuit (200) includes: The main control unit is used to control the parameter detection circuit (200) to start detection, set the carrier frequency communication signal frequency, and perform data calculation and analysis. The parameter measurement module is used to detect oxygen concentration signals through analog or digital conversion. A magnetic switch is used to stop the power supply to the device when it is not in use. The communication module is used for encoding the on / off key control communication signals and measurement signals; The power management unit provides a stable operating voltage for the communication module and the parameter measurement module.

3. The apparatus according to claim 2, characterized in that, The main control unit is a single-chip microcomputer minimum system, which is connected to the parameter measurement module via an analog or digital bus. It sets the detection frequency, reads the data sent by the parameter measurement module, processes and calibrates the data to obtain the voltage value corresponding to the oxygen concentration, and processes the voltage value and formula to obtain the oxygen concentration value. The main control unit is connected to the communication module and sends the 6M carrier frequency signal obtained by frequency doubling and the detection data to the communication module.

4. The apparatus according to claim 2, characterized in that, The communication module is a minimum XOR gate system, which uses an XOR logic to form an on / off key control signal by combining the 6MHz carrier frequency signal and the detection data.

5. The apparatus according to claim 2, characterized in that, The parameter measurement module comprises a minimum system consisting of an operational amplifier, an excitation light source, a photodiode, and a filter. It performs phosphorescence excitation and voltage signal detection on the oxygen-sensitive film (302) through the excitation light source, the photodiode, and the filter.

6. The apparatus according to claim 1, characterized in that, The oxygen detection optical path (300) includes a support structure, the polyester substrate (303) is a polyethylene terephthalate sheet, and the reflective metal film (301) is a porous aluminum foil as the reflective optical path substrate, which is disposed at the bottom of the support structure.

7. The apparatus according to claim 1, characterized in that, The oxygen-sensitive thin film (302) is prepared by the following method: Prepare a mixture of acetone and 1,2-dichloroethane in a volume ratio of 1:3; Add polymethyl methacrylate to the mixture and allow it to dissolve completely at room temperature; Add platinum octaethylporphyrin, stir thoroughly, then add coumarin 545T and continue stirring; The prepared solution was drop-coated onto a polyethylene terephthalate film and cured at room temperature to obtain an oxygen-sensitive film.

8. The apparatus according to claim 1, characterized in that, The coupling electrode (400) is a set of copper foil conformal coupling antennas.

9. The apparatus according to claim 1, characterized in that, The device has an embedded program for writing long-term system detection, specifically: the parameter detection circuit is in a low-power mode for a long time, wakes up once every 10 seconds to monitor the environment and update data before sending it.

10. A method for detecting and analyzing implantable intraperitoneal oxygen concentration, implemented based on the device described in any one of claims 1-9, characterized in that, Includes the following steps: Prepare a mixture of acetone and 1,2-dichloroethane in a volume ratio of 1:3; add polymethyl methacrylate to the mixture and allow it to dissolve completely at room temperature; add platinum octaethylporphyrin, stir thoroughly, add coumarin 545T, and continue stirring; drop the prepared solution onto a polyethylene terephthalate sheet and cure at room temperature to obtain an oxygen-sensitive film (302). The oxygen-sensitive film (302) and the polyethylene terephthalate sheet are covered with a reflective metal film (301) to obtain an oxygen detection optical path (300). The oxygen detection optical path (300) is set on the parameter detection circuit (200), the parameter detection circuit (200) is connected to the coupling electrode (400) and the battery (500), and wrapped inside by an external heat shrink tubing (100) to obtain a detection device; The detection device is placed in the abdominal cavity of the target to be tested. The oxygen in the abdominal cavity enters the oxygen detection optical path (300) through the external heat shrink tubing (100). After receiving the oxygen signal, the light intensity of the oxygen sensitive film (302) changes. The light intensity signal is excited and converted into a voltage signal through the parameter detection circuit (200) to realize the detection of oxygen concentration.

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