Application of poplatin in preparation of medicine for preventing and / or treating pulmonary fibrosis

By using salicylic acid as the active ingredient to intervene in the core pathways of pulmonary fibrosis, drugs in various dosage forms have been prepared, solving the problems of limited efficacy and numerous side effects of existing drugs, and achieving effective treatment and inhibition of pulmonary fibrosis.

CN121534040APending Publication Date: 2026-02-17SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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Patent Information

Application Number
CN202610011982.7
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-01-06
Publication Date
2026-02-17

AI Technical Summary

Technical Problem

Existing drugs for treating pulmonary fibrosis have limited efficacy, numerous side effects, and cannot reverse the disease progression. Furthermore, existing drugs have a single mechanism of action and fail to cover the multi-stage and multi-target pathogenesis of pulmonary fibrosis.

Method used

Using salicylic acid as the active ingredient, drugs for the prevention and/or treatment of pulmonary fibrosis are prepared by intervening in the core pathways of pulmonary fibrosis. These drugs include various dosage forms such as injections, oral preparations, and local targeted drug delivery. Their anti-inflammatory, antioxidant, and other bioactivities are used to intervene in pathological processes such as fibroblast activation.

Benefits of technology

Sausage extract significantly reduces the degree of pulmonary fibrosis, inhibits the expression of related markers, and suppresses fibroblast activation, providing a novel and safe treatment option for pulmonary fibrosis.

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Abstract

The invention discloses an application of poplatin in preparation of a medicine for preventing and / or treating pulmonary fibrosis, the poplatin is at least one of poplatin, a poplatin derivative or a plant extract containing the poplatin, and the poplatin derivative can be converted into the poplatin in vivo to play a role. The invention provides an application of poplatin as an active component in preparation of a medicine for preventing and / or treating pulmonary fibrosis. The poplatin is a medicine capable of intervening in a pulmonary fibrosis core pathway. According to the invention, the poplatin is used as an active component for preparing the medicine for preventing and / or treating pulmonary fibrosis for the first time.
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Citation Information

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