Traditional Chinese medicine ointment for improving pancreas islet function as well as preparation method and application of traditional Chinese medicine ointment
By preparing traditional Chinese medicine ointments, the problems of cumbersome administration and poor stability of traditional Chinese medicine decoctions and powders have been solved, achieving convenient and effective improvement of pancreatic function and blood sugar control, which is suitable for early intervention in pancreatic β-cell dysfunction.
Patent Information
- Application Number
- CN202610065402.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2026-01-19
- Publication Date
- 2026-02-17
AI Technical Summary
Traditional Chinese medicine decoctions and powders have problems such as cumbersome administration, poor stability, and insufficient precision in medication, making it difficult to effectively improve pancreatic function in the long term.
A traditional Chinese medicine ointment is prepared by using a specific ratio of Chinese herbal raw materials, which are soaked in water, decocted, concentrated, and then honey or xylitol is added to form a stable ointment that is easy to use directly, masks bitterness, improves the user experience, and ensures high concentration and stability of active ingredients through depressurized concentration.
Traditional Chinese medicine ointments are easy to use directly, improve pancreatic function, lower fasting and postprandial blood sugar, have a significant hypoglycemic effect, enhance the user experience and ensure the stability of active ingredients, making them suitable for long-term use.
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Abstract
Description
TECHNICAL FIELD
[0001] The present application relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine ointment for improving islet function and a preparation method and application thereof. BACKGROUND
[0002] Diabetes mellitus is a group of metabolic diseases characterized by chronic hyperglycemia, which has become one of the most serious global epidemics in recent years. Diabetes mellitus is mainly divided into two types: type 1 (absolute deficiency of islet beta cells) and type 2 (insulin resistance and beta cell dysfunction). Among them, type 2 diabetes accounts for more than 90%. One of the core pathological mechanisms of type 2 diabetes is the dysfunction of islet beta cells, that is, islet cells cannot secrete enough insulin to cope with the body's insulin resistance state. Although traditional Western medicine treatment can effectively reduce blood sugar, long-term use may cause side effects such as low blood sugar risk and increased liver and kidney function burden.
[0003] Traditional Chinese medicine believes that diabetes belongs to the category of "consumption", and its causes are mainly "lung heat damaging fluid, spleen deficiency failing to transport, and kidney deficiency failing to fix". Among them, the spleen and stomach are the basis of acquired, responsible for the transformation of water and nutrients; the lung is a delicate organ, responsible for gas and breathing, and the fluid is distributed on the surface; the kidney is the basis of the first generation, responsible for storing essence. Traditional Chinese medicine can regulate the body's metabolic balance through the effects of tonifying qi and nourishing yin, clearing heat and drying dampness, and promoting blood circulation to remove blood stasis.
[0004] In recent years, with the deepening of modernization research of traditional Chinese medicine, more and more traditional Chinese medicine compounds have been confirmed to have the effect of improving islet function and protecting islet beta cells. However, there are still the following main problems in clinical application:
[0005] Low compliance: Traditional Chinese medicine is mostly in the form of decoction or powder, which is cumbersome to take, and the taste is bitter and unpleasant, so it is difficult for patients, especially the elderly, to take it for a long time.
[0006] Poor stability of preparation: decoction is easy to spoil after decoction, and the active ingredients may be degraded due to long-term high temperature, making it difficult to ensure effectiveness.
[0007] Insufficient precision of medication: Traditional Chinese medicine powder is easy to be damp and caked, resulting in uneven dosage each time, making it difficult to achieve precise treatment. SUMMARY
[0008] The present application aims to solve the above technical problems, and provides a traditional Chinese medicine ointment for improving islet function and a preparation method and application thereof.
[0009] To solve the above technical problems, the technical scheme provided by the present application is as follows: a traditional Chinese medicine ointment for improving islet function, which is made of raw medicinal materials containing the following weight fractions: Ginseng 8-12 parts, Astragalus 40-60 parts, Ophiopogon japonicus 40-60 parts, Salvia miltiorrhiza 40-60 parts, Zea mays 40-60 parts, Polygonatum odoratum 40-60 parts, Trichosanthes kirilowii 20-30 parts, Taraxacum mongolicum root 20-30 parts, Dioscorea opposita 80-120 parts, Poria cocos 40-60 parts, Pueraria lobata 40-60 parts, Portulaca oleracea 20-30 parts, Potentilla chinensis 20-30 parts, Eucommia ulmoides 20-30 parts 20-30 parts of mulberry leaves, 2-3 parts of licorice root, 8-12 parts of monk fruit, 20-30 parts of rehmannia root, 20-30 parts of coptis root, 8-12 parts of chrysanthemum, 16-24 parts of honeysuckle, 120-180 parts of buckwheat, 16-24 parts of anemarrhena rhizome, 16-24 parts of cinnamon bark, 40-60 parts of bitter melon, 20-30 parts of gynostemma pentaphyllum, 20-30 parts of lycium bark, and 20-30 parts of reed rhizome.
[0010] Furthermore, the following ingredients are used: 10 parts ginseng, 50 parts astragalus, 50 parts ophiopogon japonicus, 50 parts salvia miltiorrhiza, 50 parts corn silk, 50 parts polygonatum odoratum, 25 parts trichosanthes kirilowii, 25 parts dandelion root, 100 parts yam, 50 parts poria cocos, 50 parts kudzu root, 25 parts purslane, 25 parts potassium tsao-ko, 25 parts eucommia ulmoides, 25 parts mulberry leaf, 2.5 parts licorice, 10 parts monk fruit, 25 parts rehmannia glutinosa, 25 parts coptis chinensis, 10 parts chrysanthemum, 20 parts honeysuckle, 150 parts buckwheat, 20 parts anemarrhena asphodeloides, 20 parts cinnamon, 50 parts bitter melon, 25 parts gynostemma pentaphyllum, 25 parts lycium chinense root bark, and 25 parts reed rhizome.
[0011] Furthermore, the dosage form of the composition is an ointment.
[0012] A method for preparing a traditional Chinese medicine ointment for improving pancreatic function includes the following steps: (a) Weigh each raw material according to the formula, add water to soak, the amount of water is 6-10 times the total weight of the raw materials, and the soaking time is 2-8 hours; (b) Decoction twice, each time for 1-3 hours, and combine the decoctions obtained from the two decoctions; (c) Filter the combined drug solution and concentrate it to a clear extract with a relative density of 1.10-1.25 at 60°C; (d) Add the prescribed amount of honey, xylitol or allulose to the ointment, and optionally add 0.1-0.5% of the total weight of the medicinal materials as a flavoring agent. Heat and stir, and continue to concentrate and thicken the ointment until the ointment “drops into beads” or “stretches into flags” in cold water. (e) Cool to room temperature, dispense, sterilize, and the product is ready.
[0013] Furthermore, in step (c), the concentration is carried out under reduced pressure at a temperature of 50-70°C.
[0014] Furthermore, the amount of honey, xylitol, or allulose added in step (d) is 10-30% of the weight of the extract.
[0015] The application of a traditional Chinese medicine ointment for improving pancreatic function in the preparation of health products for assisting in lowering fasting blood glucose or postprandial blood glucose.
[0016] The use of a traditional Chinese medicine ointment for improving pancreatic function in the preparation of a pharmaceutical composition for the prevention or adjunctive treatment of type 2 diabetes.
[0017] The advantages of this invention compared to existing technologies are as follows: The ointment can be taken directly in small quantities after preparation, eliminating the need for secondary cooking and greatly facilitating daily use by patients; the addition of honey or xylitol as a flavoring agent not only masks the bitterness of the original medicinal materials but also provides auxiliary effects such as moisturizing the lungs, relieving cough, and replenishing qi and blood, thus enhancing the patient's experience; the use of a decompression concentration process concentrates the liquid to a relative density of 1.10-1.25, ensuring a high concentration and stability of the active ingredients, which is beneficial for long-term storage and transportation; the formula contains qi-tonifying herbs, heat-clearing and dampness-drying herbs, and blood-activating and stasis-removing herbs, realizing the comprehensive treatment concept of "tonifying deficiency and purging excess, supporting the body's resistance and eliminating pathogens," making it particularly suitable for early intervention in pancreatic β-cell dysfunction. Detailed Implementation
[0018] To make the technical problems, solutions, and beneficial effects of this invention clearer, the invention will be further described in detail below with reference to embodiments. It should be understood that the specific embodiments described herein are merely illustrative and not intended to limit the invention.
[0019] Example 1: Preparation of Traditional Chinese Medicine Ointment Raw materials: 10 parts ginseng, 50 parts astragalus, 50 parts ophiopogon japonicus, 50 parts salvia miltiorrhiza, 50 parts corn silk, 50 parts polygonatum odoratum, 25 parts trichosanthes kirilowii root, 25 parts dandelion root, 100 parts yam, 50 parts poria cocos, 50 parts kudzu root, 25 parts purslane, 25 parts potassium tsao-ko, 25 parts eucommia ulmoides, 25 parts mulberry leaf, 2.5 parts licorice, 10 parts monk fruit, 25 parts rehmannia glutinosa, 25 parts coptis chinensis, 10 parts chrysanthemum, 20 parts honeysuckle, 150 parts buckwheat, 20 parts anemarrhena asphodeloides, 20 parts cinnamon, 50 parts bitter melon, 25 parts gynostemma pentaphyllum, 25 parts lycium chinense root bark, and 25 parts reed rhizome.
[0020] The preparation steps are as follows: (a) After cleaning and weighing the above-mentioned medicinal materials, mix them and place them in an extraction device. Add drinking water (including deionized water or purified water) at 10 times the total weight of the medicinal materials and soak at room temperature for 2-4 hours (until the medicinal materials have fully absorbed water).
[0021] (b) Heat to a boil, then maintain a gentle simmer (with the water surface slightly rippling) and simmer for 2 hours. Filter and collect the first decoction. Add water equal to 10 times the total weight of the herbs to the dregs and simmer for 1.5 hours. Filter again and collect the second decoction. Combine the two decoctions.
[0022] (c) The combined drug solution was concentrated under reduced pressure, with the temperature controlled at around 60°C, until a clear paste with a relative density of approximately 1.18 was obtained at 60°C.
[0023] (d) Add 10% of the weight of honey (not exceeding 10% of the weight of the extract) and 0.2% of the total weight of the medicinal materials as steviol glycosides (flavoring agent) to the obtained extract, heat and stir constantly to continue concentrating. During this process, use a bamboo stick to dip into the extract and drop it into cold water for observation. The extract is considered to have reached the standard of "dropping into water to form beads" and having a cooling and moisturizing effect when the drop does not disperse in the cold water and sinks in a bead shape.
[0024] (e) Stop heating, cool the ointment to room temperature, dispense it, and sterilize it with Co-60 irradiation (dose of 8kGy) to obtain the finished Chinese herbal ointment product of the present invention.
[0025] Example 2: Preparation of Traditional Chinese Medicine Ointment Raw materials: 8 parts ginseng, 40 parts astragalus, 40 parts ophiopogon japonicus, 40 parts salvia miltiorrhiza, 40 parts corn silk, 40 parts polygonatum odoratum, 20 parts trichosanthes kirilowii root, 20 parts dandelion root, 80 parts yam, 40 parts poria cocos, 40 parts kudzu root, 20 parts purslane, 20 parts potassium tsao-ko, 20 parts eucommia ulmoides, 20 parts mulberry leaf, 2 parts licorice root, 8 parts monk fruit, 20 parts rehmannia glutinosa, 20 parts coptis chinensis, 8 parts chrysanthemum, 16 parts honeysuckle, 120 parts buckwheat, 16 parts anemarrhena asphodeloides, 16 parts cinnamon, 40 parts bitter melon, 20 parts gynostemma pentaphyllum, 20 parts lycium chinense root bark, and 20 parts reed rhizome.
[0026] The preparation steps are the same as in Example 1.
[0027] Example 3: Preparation of Traditional Chinese Medicine Ointment Raw materials: 12 parts ginseng, 60 parts astragalus, 60 parts ophiopogon japonicus, 60 parts salvia miltiorrhiza, 60 parts corn silk, 60 parts polygonatum odoratum, 30 parts trichosanthes kirilowii, 30 parts dandelion root, 120 parts yam, 60 parts poria cocos, 60 parts kudzu root, 30 parts purslane, 30 parts potassium japonicum, 30 parts eucommia ulmoides, 30 parts mulberry leaf, 3 parts licorice, 12 parts monk fruit, 30 parts rehmannia glutinosa, 30 parts coptis chinensis, 12 parts chrysanthemum, 24 parts honeysuckle, 180 parts buckwheat, 24 parts anemarrhena asphodeloides, 24 parts cinnamon, 60 parts bitter melon, 30 parts gynostemma pentaphyllum, 30 parts lycium chinense root bark, and 30 parts reed rhizome.
[0028] The preparation steps are the same as in Example 1.
[0029] Comparative Example 1: Group containing only the principal drug To verify the importance of the "assistant, adjuvant, and guiding" herbs in the formula, this comparative example was set up. Only the principal herbs with qi-tonifying and yin-nourishing effects were weighed: 10 parts ginseng, 50 parts astragalus, 50 parts ophiopogon japonicus, 50 parts polygonatum odoratum, 25 parts trichosanthes kirilowii, and 25 parts rehmannia glutinosa. The preparation method was the same as in Example 1, and the ointment of Comparative Example 1 was obtained.
[0030] Comparative Example 2: Group without blood-activating drugs To verify the role of the blood-activating and meridian-clearing components (Salvia miltiorrhiza and Pueraria lobata) in the formula, this comparative example was set up. All raw materials except Salvia miltiorrhiza and Pueraria lobata were weighed and prepared as follows: 10 parts ginseng, 50 parts Astragalus membranaceus, 50 parts Ophiopogon japonicus, 50 parts corn silk, 50 parts Polygonatum odoratum, 25 parts Trichosanthes kirilowii, 25 parts Taraxacum mongolicum root, 100 parts Dioscorea opposita, 50 parts Poria cocos, 25 parts Portulaca oleracea, 25 parts Potentilla chinensis, 25 parts Eucommia ulmoides, 25 parts Morus alba leaf, 2.5 parts Glycyrrhiza uralensis, 10 parts Siraitia grosvenorii, 25 parts Rehmannia glutinosa, 25 parts Coptis chinensis, 10 parts Chrysanthemum morifolium, 20 parts Lonicera japonica, 150 parts Buckwheat, 20 parts Anemarrhena asphodeloides, 20 parts Cinnamomum cassia, 50 parts Bitter melon, 25 parts Gynostemma pentaphyllum, 25 parts Lycium chinense root bark, and 25 parts Phragmites communis rhizome. The preparation method was the same as in Example 1, resulting in the ointment of Comparative Example 2.
[0031] Comparative Example 3: Group without heat-clearing drugs To verify the effects of the heat-clearing and fire-purging components (Coptis chinensis, Anemarrhena asphodeloides, and Bitter Melon) in the formula, this comparative example was set up. All raw materials except for Coptis chinensis, Anemarrhena asphodeloides, and Bitter Melon were weighed and prepared as follows: 10 parts ginseng, 50 parts Astragalus membranaceus, 50 parts Ophiopogon japonicus, 50 parts Salvia miltiorrhiza, 50 parts corn silk, 50 parts Polygonatum odoratum, 25 parts Trichosanthes kirilowii, 25 parts Taraxacum mongolicum root, 100 parts Dioscorea opposita, 50 parts Poria cocos, 50 parts Pueraria lobata, 25 parts Portulaca oleracea, 25 parts Potentilla chinensis, 25 parts Eucommia ulmoides, 25 parts Morus alba leaf, 2.5 parts Glycyrrhiza uralensis, 10 parts Siraitia grosvenorii, 25 parts Rehmannia glutinosa, 10 parts Chrysanthemum morifolium, 20 parts Lonicera japonica, 150 parts Buckwheat, 20 parts Cinnamomum cassia, 25 parts Gynostemma pentaphyllum, 25 parts Lycium chinense root bark, and 25 parts Phragmites communis rhizome. The preparation method was the same as in Example 1, resulting in Comparative Example 3 ointment.
[0032] Experimental Example: Pharmacodynamic Comparison Trial To verify the effectiveness of the herbal ointment of this invention, the synergistic effect of the formulation, and the rationality of the ratio range, the following animal experiments were conducted.
[0033] 1. Model Establishment: Healthy male C57BL / 6J mice (weight 20±2g) were selected and fed a high-fat diet for 4 weeks. A type 2 diabetes model was induced by intraperitoneal injection of streptozotocin (STZ, 40mg / kg). A fasting blood glucose (FBG) level ≥11.1mmol / L was considered a successful model establishment criterion.
[0034] 2. Grouping and Administration: Mice with successfully induced modeling were randomly divided into 9 groups of 10 mice each: model control group, positive drug control group (metformin, 200 mg / kg / d), Example 1 group, Example 2 group, Example 3 group, Comparative Example 1 group, Comparative Example 2 group, and Comparative Example 3 group. A normal control group (n=10) was also included. Each administration group was administered the corresponding ointment by gavage at a dose of 200 mg / kg / d (i.e., 10 g ointment / kg / d; 10 g ointment / kg / d is considered one dose unit, and the specific dosage is approximately 2 g ointment / 10 g body weight per mouse). The model group and the normal control group received an equal volume of purified water. Administration continued for 6 weeks.
[0035] 3. Detection indicators and methods: Fasting blood glucose (FBG): Before administration (week 0) and at the end of week 2, 4 and 6 after administration, mice were fasted for 12 hours but allowed free access to water. Blood was collected from the tail vein and FBG was measured using a blood glucose meter.
[0036] Oral glucose tolerance test (OGTT): The test was conducted at the end of week 6 after administration of the drug. Mice were fasted for 12 hours and then administered glucose solution (2.0 g / kg) by gavage. Blood glucose levels were measured before administration (0 min) and at 30, 60 and 120 min after administration, and the area under the blood glucose curve (AUC) was calculated.
[0037] 4. Statistical analysis: Experimental data are expressed as mean ± standard deviation (x ± s). One-way ANOVA was performed using SPSS 22.0 software. LSD-t test was used for pairwise comparisons between groups. P < 0.05 was considered statistically significant.
[0038] Experimental results Table 1 Comparison of fasting blood glucose (FBG) changes at different time points after drug administration in mice of different groups (x±s, n=10, mmol / L) Table 2 Comparison of oral glucose tolerance test (OGTT) results in mice of different groups after 6 weeks of drug administration (x±s, n=10) Results Analysis 1. Efficacy Verification: As shown in Tables 1 and 2, compared with the model control group, fasting blood glucose levels in groups 1, 2, and 3 of this invention began to decrease significantly after two weeks of continuous administration, and the hypoglycemic effect increased with prolonged administration time. In the OGTT test, the blood glucose levels and AUC of each group of this invention at each time point were significantly lower than those of the model group, and their effect on improving glucose tolerance was comparable to that of the positive control group of metformin. This fully demonstrates that the ointment of this invention has a clear auxiliary effect in reducing fasting and postprandial blood glucose and improving glucose tolerance.
[0039] 2. Validation of formulation compatibility and synergy: The hypoglycemic effect of Comparative Example 1 (the group with only the principal drug) was the weakest, with no significant difference from the model group throughout the entire experimental period (P>0.05), and the OGTT-AUC was also significantly higher than that of the groups in this invention (P<0.01). This indicates that simply "tonifying qi and nourishing yin" is insufficient to effectively control blood sugar, verifying the necessity of the comprehensive formula.
[0040] Although the hypoglycemic effects of Comparative Example 2 (excluding blood-activating drugs) and Comparative Example 3 (excluding heat-clearing drugs) showed some statistical significance in the later stage of administration (6 weeks) (P<0.05), their FBG levels and OGTT-AUC were significantly inferior to those of Example 1 of this invention (P<0.05). This indicates that the overall efficacy of the formula lacking either the treatment of "activating blood circulation and unblocking collaterals" or "clearing heat and purging fire" is greatly reduced, thus proving the scientific nature and synergistic effect of the compound treatment of "tonifying qi and nourishing yin, clearing heat and activating blood circulation, and strengthening spleen and resolving turbidity" of this invention.
[0041] 2. Verification of the rationality of the formulation range: Among the three groups of Example 1 (preferred formulation), Example 2 (lower limit formulation), and Example 3 (upper limit formulation), there were no significant differences in FBG and OGTT indicators at each time point (P>0.05). This indicates that the ointments prepared within the weight range of the present invention can maintain stable and good efficacy.
[0042] The above experimental results demonstrate that the herbal ointment provided by this invention has a rigorous formulation and scientific compatibility. Within the specified ratio range, it can produce drugs that significantly improve glucose metabolism disorders in type 2 diabetic model mice. Its efficacy is significantly superior to formulations lacking key treatment principles (such as promoting blood circulation and clearing heat), proving the advantages of the comprehensive formula's multi-target and multi-pathway synergistic treatment.
[0043] The present invention and its embodiments have been described above. This description is not restrictive, and the embodiments shown are only one of the embodiments of the present invention. The actual structure is not limited to this. In conclusion, if those skilled in the art are inspired by this description and design similar structures and embodiments without departing from the spirit of the present invention, they should all fall within the protection scope of the present invention.
Claims
1. A traditional Chinese medicine ointment for improving pancreatic function, characterized in that: Made from active pharmaceutical ingredients comprising the following parts by weight: Ginseng 8-12 parts, Astragalus 40-60 parts, Ophiopogon japonicus 40-60 parts, Salvia miltiorrhiza 40-60 parts, Zea mays 40-60 parts, Polygonatum odoratum 40-60 parts, Trichosanthes kirilowii 20-30 parts, Taraxacum mongolicum root 20-30 parts, Dioscorea opposita 80-120 parts, Poria cocos 40-60 parts, Pueraria lobata 40-60 parts, Portulaca oleracea 20-30 parts, Potentilla chinensis 20-30 parts, Eucommia ulmoides 20-30 parts 20-30 parts of mulberry leaves, 2-3 parts of licorice root, 8-12 parts of monk fruit, 20-30 parts of rehmannia root, 20-30 parts of coptis root, 8-12 parts of chrysanthemum, 16-24 parts of honeysuckle, 120-180 parts of buckwheat, 16-24 parts of anemarrhena rhizome, 16-24 parts of cinnamon bark, 40-60 parts of bitter melon, 20-30 parts of gynostemma pentaphyllum, 20-30 parts of lycium bark, and 20-30 parts of reed rhizome.
2. The traditional Chinese medicine ointment for improving pancreatic function according to claim 1, characterized in that: Ginseng 10 parts, Astragalus 50 parts, Ophiopogon japonicus 50 parts, Salvia miltiorrhiza 50 parts, Corn silk 50 parts, Polygonatum odoratum 50 parts, Trichosanthes kirilowii 25 parts, Taraxacum mongolicum root 25 parts, Dioscorea opposita 100 parts, Poria cocos 50 parts, Pueraria lobata 50 parts, Portulaca oleracea 25 parts, Potentilla chinensis 25 parts, Eucommia ulmoides 25 parts, Mulberry leaf 25 parts, Licorice 2.5 parts, Siraitia grosvenorii 10 parts, Rehmannia glutinosa 25 parts, Coptis chinensis 25 parts, Chrysanthemum morifolium 10 parts, Lonicera japonica 20 parts, Buckwheat 150 parts, Anemarrhena asphodeloides 20 parts, Cinnamomum cassia 20 parts, Bitter melon 50 parts, Gynostemma pentaphyllum 25 parts, Lycium chinense root bark 25 parts, Phragmites communis rhizome 25 parts.
3. A traditional Chinese medicine ointment for improving pancreatic function according to claim 1 or 2, characterized in that, The composition is in the form of an ointment.
4. A method for preparing a traditional Chinese medicine ointment for improving pancreatic function, characterized in that: Includes the following steps: (a) Weigh each raw material according to the formula, add water to soak, the amount of water is 6-10 times the total weight of the raw materials, and the soaking time is 2-8 hours; (b) Decoction twice, each time for 1-3 hours, and combine the decoctions obtained from the two decoctions; (c) Filter the combined drug solution and concentrate it to a clear extract with a relative density of 1.10-1.25 at 60°C; (d) Add the prescribed amount of honey, xylitol or allulose to the ointment, and optionally add 0.1-0.5% of the total weight of the medicinal materials as a flavoring agent, heat and stir, and continue to concentrate and thicken the ointment until the ointment "drops into beads" or "stretches into flags" in cold water; (e) Cool to room temperature, dispense, sterilize, and the product is ready.
5. The method for preparing a traditional Chinese medicine ointment for improving pancreatic function according to claim 4, characterized in that: In step (c), the concentration is carried out under reduced pressure at a temperature of 50-70°C.
6. The method for preparing a traditional Chinese medicine ointment for improving pancreatic function according to claim 3, characterized in that: The amount of honey, xylitol, or allulose added in step (d) is 10-30% of the weight of the extract.
7. The application of the traditional Chinese medicine ointment for improving pancreatic function as described in claim 1 or 2 in the preparation of health products for assisting in lowering fasting blood glucose or postprandial blood glucose.
8. The use of a traditional Chinese medicine ointment for improving pancreatic function as described in claim 1 or 2 in the preparation of a pharmaceutical composition for the prevention or adjunctive treatment of type 2 diabetes.