Ultra-low volume liquid containing pyraclostrobin and tebuconazole

Abstract

The invention relates to an ultra-low volume liquid containing pyraclostrobin and tebuconazole, which belongs to the field of pesticide preparations and mainly comprises the following components in percentage by weight: 5-15% of pyraclostrobin, 5-15% of tebuconazole and the balance of water. 10%-20% of tebuconazole; 10%-20% of a cosolvent; 3%-8% of a penetrant; 5%-15% of an evaporation inhibitor; 2%-5% of a stabilizer; the total percentage is 100%. Through specific component selection and proportion optimization, the prepared liquid has proper viscosity, surface tension, volatility and specific gravity, and is especially suitable for ultra-low volume spraying and aviation pesticide application. The preparation is excellent in atomization performance, moderate in fogdrop particle size, low in drifting risk and good in deposition effect, the pesticide utilization rate can be remarkably increased, efficient and synergistic control over crop diseases is achieved, and environmental pollution is reduced.

Description

Technical Field

[0001] This invention belongs to the field of pesticide formulation technology, specifically relating to an ultra-low volume liquid formulation containing pyraclostrobin and tebuconazole. Background Technology

[0002] Pyraclostrobin and tebuconazole are two highly effective fungicides with different mechanisms of action. Pyraclostrobin belongs to the methoxyacrylate class and effectively controls various fungal diseases by inhibiting mitochondrial respiration; tebuconazole belongs to the triazole class and works by inhibiting ergosterol biosynthesis. The combination of the two has the advantages of synergistic effect, broadened fungicidal spectrum, and delayed resistance development.

[0003] Currently, formulations containing these two active ingredients are mostly wettable powders, water-dispersible granules, or conventional emulsifiable concentrates, requiring large amounts of water for dilution before conventional spraying. This not only consumes significant manpower and resources but also limits its application in water-scarce areas, mountainous regions, or large-scale farms. Ultra-low volume (ULV) spraying technology offers advantages such as high efficiency, low water consumption, and minimal pesticide loss, but it places specific requirements on the formulation itself. Direct ULV spraying of conventional formulations presents problems such as poor atomization performance, easy droplet evaporation and drift, active ingredient decomposition, high risk of phytotoxicity, and corrosion of application equipment.

[0004] Therefore, developing a specialized liquid formulation designed specifically for pyraclostrobin and tebuconazole, with stable performance and suitable for ultra-low volume application, is of great significance for improving disease control efficiency, saving resources, and protecting the environment.

[0005] Existing radiation devices are mostly simple motor-driven winding rollers that release the spun yarn. Their functions are limited, and they can only play a basic guiding role. They cannot effectively solve the problem of spin and entanglement caused by the high-speed movement of the spun yarn. Therefore, there is an urgent need for a device that can effectively prevent the spun yarn from tangling and make it radiate evenly and stably. Summary of the Invention

[0006] To address the shortcomings of existing pyraclostrobin and tebuconazole formulations that are unsuitable for ultra-low volume spraying, this invention provides an ultra-low volume liquid formulation containing pyraclostrobin and tebuconazole, characterized by good atomization performance, drift resistance, and high stability, as well as its preparation method.

[0007] The technical solution adopted by this invention to solve the technical problem is as follows: The present invention provides an ultra-low volume liquid formulation containing pyraclostrobin and tebuconazole, which is mainly composed of the following components by weight percentage: Pyraclostrobin 5%-15%; Tebuconazole 10%-20%; 10%-20% cosolvent; Penetrant 3%-8%; Evaporation inhibitors: 5%-15%; Stabilizer 2%-5%; Add the specific gravity adjuster to 100%.

[0008] In a preferred embodiment, the co-solvent is selected from one of N-methylpyrrolidone, dipropylene glycol dimethyl ether (DGBE), dimethyl sulfoxide (DMSO), dihydroglucoside (Cyrene), and γ-butyrolactone (GBL).

[0009] In a preferred embodiment, the penetrant is selected from one of fatty alcohol polyoxyethylene ether, alkylphenol polyoxyethylene ether, octylphenol polyoxyethylene ether-10, sorbitan fatty acid ester, and ethylene oxide-propylene oxide block copolymer.

[0010] In a preferred embodiment, the evaporation inhibitor is selected from one of the following: vegetable oil ethylene oxide adduct, monochloroethane, dichloroethane, and 1,2-dichloroethane.

[0011] In a preferred embodiment, the vegetable oil ethylene oxide adduct is castor oil polyoxyethylene ether or turpentine oil ethylene oxide.

[0012] In a preferred embodiment, the stabilizer is selected from one of epoxidized soybean oil, calcium chloride, calcium nitrate, calcium sulfate, and calcium carbonate.

[0013] In a preferred embodiment, the specific gravity adjuster is selected from one of triphenyl phosphate, diphenyl phosphate, diisopropylphenyl phosphate, tricresyl phosphate, dioctyl phthalate, and trioctyl trimellitate.

[0014] As a preferred embodiment, the physicochemical properties of the ultra-low volume liquid agent meet the following requirements: viscosity (25°C) in the range of 15-25 mPa·s, and surface tension in the range of 25-30 mN / m.

[0015] The present invention provides a method for preparing an ultra-low volume liquid containing pyraclostrobin and tebuconazole, which specifically includes the following steps: Step S1: Add the formulated amounts of co-solvent and specific gravity adjuster sequentially to the reaction vessel, and start stirring; Step S2: While stirring, slowly add the formulated amounts of pyraclostrobin and tebuconazole to the mixed solvent from step S1, and continue stirring until completely dissolved to form a uniform and transparent solution. Step S3: Add the penetrant, evaporation inhibitor and stabilizer to the drug solution obtained in step S2 in sequence, increase the rotation speed to 300-400 r / min, and stir at a constant temperature for 30-45 minutes to ensure that the system is completely homogeneous; Step S4: Filter the mixture obtained in step S3, and after sampling and testing to ensure it passes the test, the ultra-low volume liquid product is obtained.

[0016] In a preferred embodiment, the stirring speed in step S1 is 100-200 r / min.

[0017] The beneficial effects of this invention are: 1. Synergistic effect and resistance management: The combination of pyraclostrobin and tebuconazole has complementary mechanisms of action, which can effectively synergistically control various foliar diseases of crops such as powdery mildew, rust and leaf spot, and can effectively delay the development of pathogen resistance.

[0018] 2. Specifically designed for ultra-low volume spraying: Through scientifically designed additive system, the formulation has suitable viscosity, surface tension and low volatility, ensuring that the droplet size (VMD) is concentrated in the range of 80-150 micrometers, with good atomization characteristics, anti-drift ability and target deposition.

[0019] 3. Improved work efficiency and resource conservation: This formulation can be applied directly or after slight dilution via ULV spraying or aerial application. The amount of liquid applied per acre can be as low as 0.5-1.5 liters, which greatly improves work efficiency and is particularly suitable for large-scale integrated pest management and water-scarce areas.

[0020] 4. Enhanced adhesion and penetration: The added penetrant promotes the spread and penetration of the pesticide solution on the surface of crop leaves, improves the resistance to rain washout, and thus extends the duration of effectiveness and control effect.

[0021] 5. High stability and safety: The selected stabilizers and cosolvents effectively prevent the decomposition of active ingredients during storage and spraying, while the evaporation inhibitors reduce the volatilization of droplets in the air, improving operational safety and reducing the impact on the environment and non-target organisms. Detailed Implementation

[0022] In a first aspect, the present invention provides an ultra-low volume liquid containing pyraclostrobin and tebuconazole.

[0023] The present invention provides an ultra-low volume liquid formulation containing pyraclostrobin and tebuconazole, which is mainly composed of the following components by weight percentage: Pyraclostrobin 5%-15%; Tebuconazole 10%-20%; 10%-20% cosolvent; Penetrant 3%-8%; Evaporation inhibitors: 5%-15%; Stabilizer 2%-5%; Add the specific gravity adjuster to 100%.

[0024] Preferably, the co-solvent is selected from one of N-methylpyrrolidone, dipropylene glycol dimethyl ether (DGBE), dimethyl sulfoxide (DMSO), dihydro-L-glucoside (Cyrene), and γ-butyrolactone (GBL).

[0025] Preferably, the penetrant is selected from one of fatty alcohol polyoxyethylene ether, alkylphenol polyoxyethylene ether, octylphenol polyoxyethylene ether-10, sorbitan fatty acid ester, and ethylene oxide-propylene oxide block copolymer.

[0026] Preferably, the evaporation inhibitor is selected from one of the following: vegetable oil ethylene oxide adduct, monochloroethane, dichloroethane, and 1,2-dichloroethane.

[0027] Preferably, the vegetable oil ethylene oxide adduct is castor oil polyoxyethylene ether or turpentine oil ethylene oxide.

[0028] Preferably, the stabilizer is selected from one of epoxidized soybean oil, calcium chloride, calcium nitrate, calcium sulfate, and calcium carbonate.

[0029] Preferably, the specific gravity adjuster is selected from one of triphenyl phosphate, diphenyl phosphate, diisopropylphenyl phosphate, tricresyl phosphate, dioctyl phthalate, and trioctyl trimellitate.

[0030] Preferably, the physicochemical properties of the ultra-low volume liquid agent are: viscosity (25℃) in the range of 15-25 mPa·s, and surface tension in the range of 25-30 mN / m.

[0031] Secondly, the present invention provides a method for preparing an ultra-low volume liquid containing pyraclostrobin and tebuconazole.

[0032] The present invention provides a method for preparing an ultra-low volume liquid containing pyraclostrobin and tebuconazole, which specifically includes the following steps: Step S1: Add the formulated amounts of co-solvent and specific gravity adjuster sequentially to the reaction vessel, and start stirring; Step S2: While stirring, slowly add the formulated amounts of pyraclostrobin and tebuconazole to the mixed solvent from step S1, and continue stirring until completely dissolved to form a uniform and transparent solution. Step S3: Add the penetrant, evaporation inhibitor and stabilizer to the drug solution obtained in step S2 in sequence, increase the rotation speed to 300-400 r / min, and stir at a constant temperature for 30-45 minutes to ensure that the system is completely homogeneous; Step S4: Filter the mixture obtained in step S3, and after sampling and testing to ensure it passes the test, the ultra-low volume liquid product is obtained.

[0033] Preferably, in step S1, the stirring speed is 100-200 r / min.

[0034] The present invention provides an ultra-low volume liquid containing pyraclostrobin and tebuconazole, which is mainly composed of the methoxyacrylate fungicide pyraclostrobin and the triazole fungicide tebuconazole, and is suitable for ultra-low volume spraying technology.

[0035] This invention provides an ultra-low volume liquid formulation containing pyraclostrobin and tebuconazole, mainly composed of active ingredients (pyraclostrobin, a methoxyacrylate fungicide, and tebuconazole, a triazole fungicide), solubilizer, penetrant, evaporation inhibitor, stabilizer, and specific gravity regulator. The active ingredients are a synergistic combination of pyraclostrobin and tebuconazole. Through specific component selection and ratio optimization, this invention produces a liquid formulation with suitable viscosity, surface tension, volatility, and specific gravity, making it particularly suitable for ultra-low volume spraying and aerial application. This formulation exhibits excellent atomization performance, moderate droplet size, low drift risk, and good deposition effect, significantly improving pesticide utilization, achieving efficient synergistic control of crop diseases, and reducing environmental pollution.

[0036] The technical solutions of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention. Example

[0037] An ultra-low volume liquid formulation containing pyraclostrobin and tebuconazole, comprising the following components by weight percentage: 8% pyraclostrobin; Tebuconazole 12%; N-methylpyrrolidone 15%; 5% fatty alcohol polyoxyethylene ether; Castor oil polyoxyethylene ether 10%; Epoxidized soybean oil 3%; Triphenyl phosphate was added to bring the total to 100%.

[0038] Its preparation method is as follows: S1: Add the formulated amount of cosolvent and specific gravity regulator to the reactor in sequence, start stirring, and control the speed to 150 r / min; S2: While stirring, slowly add the formulated amounts of pyraclostrobin and tebuconazole to the mixed solvent from step S1, and continue stirring until completely dissolved to form a uniform and transparent solution. S3: Add the penetrant, evaporation inhibitor and stabilizer to the drug solution obtained in step S2 in sequence, increase the rotation speed to 350 r / min, and stir at a constant temperature (25℃) for 40 minutes to ensure that the system is completely homogeneous; S4: Filter the mixture obtained in step S3 through a 5μm filter bag. After sampling and testing, the ultra-low volume liquid product is obtained. Example

[0039] An ultra-low volume liquid formulation containing pyraclostrobin and tebuconazole, comprising the following components by weight percentage: Pyraclostrobin 12%; Tebuconazole 18%; N-methylpyrrolidone 18%; Fatty alcohol polyoxyethylene ether 6%; Castor oil polyoxyethylene ether 12%; Epoxidized soybean oil 4%; Triphenyl phosphate was added to bring the total to 100%.

[0040] Its preparation method is as follows: S1: Add the formulated amount of cosolvent and specific gravity regulator to the reactor in sequence, start stirring, and control the speed to 150 r / min; S2: While stirring, slowly add the formulated amounts of pyraclostrobin and tebuconazole to the mixed solvent from step S1, and continue stirring until completely dissolved to form a uniform and transparent solution. S3: Add the penetrant, evaporation inhibitor and stabilizer to the drug solution obtained in step S2 in sequence, increase the rotation speed to 350 r / min, and stir at a constant temperature (25℃) for 40 minutes to ensure that the system is completely homogeneous; S4: Filter the mixture obtained in step S3 through a 5μm filter bag. After sampling and testing, the ultra-low volume liquid product is obtained. Example

[0041] An ultra-low volume liquid formulation containing pyraclostrobin and tebuconazole, comprising the following components by weight percentage: Pyraclostrobin 15%; Tebuconazole 10%; Dipropylene glycol dimethyl ether (DGBE) 20%; Alkylphenol polyoxyethylene ether 7%; Turpentine oil contains 14% ethylene oxide; Calcium chloride 3%; Diphenyl phosphate was added to bring the total to 100%.

[0042] Its preparation method is as follows: S1: Add the formulated amount of cosolvent and specific gravity regulator to the reactor in sequence, start stirring, and control the speed to 180 r / min; S2: While stirring, slowly add the formulated amounts of pyraclostrobin and tebuconazole to the mixed solvent from step S1, and continue stirring until completely dissolved to form a uniform and transparent solution. S3: Add the penetrant, evaporation inhibitor and stabilizer to the drug solution obtained in step S2 in sequence, increase the rotation speed to 380 r / min, and stir at a constant temperature (25℃) for 35 minutes to ensure that the system is completely homogeneous; S4: Filter the mixture obtained in step S3 through a 5μm filter bag. After sampling and testing, the ultra-low volume liquid product is obtained. Example

[0043] An ultra-low volume liquid formulation containing pyraclostrobin and tebuconazole, comprising the following components by weight percentage: 9% pyraclostrobin; Tebuconazole 17%; γ-Butyrolactone (GBL) 19%; 7% dehydrated sorbitan fatty acid esters; 1,2-Dichloroethane 13%; Calcium carbonate 2%; Dioctyl phthalate is added to bring the total to 100%.

[0044] Its preparation method is as follows: S1: Add the formulated amount of cosolvent and specific gravity regulator to the reactor in sequence, start stirring, and control the speed to 170 r / min; S2: While stirring, slowly add the formulated amounts of pyraclostrobin and tebuconazole to the mixed solvent from step S1, and continue stirring until completely dissolved to form a uniform and transparent solution. S3: Add the penetrant, evaporation inhibitor and stabilizer to the drug solution obtained in step S2 in sequence, increase the rotation speed to 400 r / min, and stir at a constant temperature (25℃) for 30 minutes to ensure that the system is completely homogeneous; S4: Filter the mixture obtained in step S3 through a 5μm filter bag. After sampling and testing, the ultra-low volume liquid product is obtained. Example

[0045] An ultra-low volume liquid formulation containing pyraclostrobin and tebuconazole, comprising the following components by weight percentage: 10% pyraclostrobin; Tebuconazole 10%; Cyrene (15%), a dihydro-L-glucoside, is mentioned. 8% ethylene oxide-propylene oxide block copolymer; Dichloroethane 15%; Epoxidized soybean oil 4%; Trimethylbenzene trioctyl to bring the total to 100%.

[0046] Its preparation method is as follows: S1: Add the formulated amount of cosolvent and specific gravity regulator to the reactor in sequence, start stirring, and control the speed to 120 r / min; S2: While stirring, slowly add the formulated amounts of pyraclostrobin and tebuconazole to the mixed solvent from step S1, and continue stirring until completely dissolved to form a uniform and transparent solution. S3: Add the penetrant, evaporation inhibitor and stabilizer to the drug solution obtained in step S2 in sequence, increase the rotation speed to 330 r / min, and stir at a constant temperature (25℃) for 40 minutes to ensure that the system is completely homogeneous; S4: Filter the mixture obtained in step S3 through a 5μm filter bag. After sampling and testing, the ultra-low volume liquid product is obtained.

[0047] Experimental Example 1: Performance Testing and Field Trials 1. Physicochemical properties test: The formulation prepared in Example 1 was tested and its viscosity (25℃) was 20.5 mPa·s and its surface tension was 27.8 mN / m, both of which meet the standard requirements for ultra-low volume liquids.

[0048] 2. Droplet size determination: Using a laser droplet analyzer, the volume median diameter of the formulation is 115 micrometers, and the atomization band is narrow, which meets the requirements for efficient deposition.

[0049] 3. Field efficacy test: During the wheat flowering stage, the formulation prepared in Example 1 of this invention was sprayed using a drone at a dosage of 80 ml per mu (approximately 0.067 hectares). 21 days after application, the control efficacy against wheat powdery mildew and rust was 94.2% and 92.7%, respectively, significantly better than the control area treated with conventional manual spraying. Furthermore, it saved over 90% of water and increased control efficiency by approximately 10 times.

[0050] This invention discloses an ultra-low volume liquid formulation containing pyraclostrobin and tebuconazole. Those skilled in the art can refer to the content of this document and appropriately modify the process parameters to achieve the desired formulation. It should be particularly noted that all similar substitutions and modifications are obvious to those skilled in the art and are considered to be included in this invention. The product of this invention has been described through preferred embodiments, and those skilled in the art will clearly be able to modify or appropriately change and combine the product described herein without departing from the content, spirit, and scope of this invention to realize and apply the technology of this invention.

Claims

1. An ultra-low volume liquid containing pyraclostrobin and tebuconazole, characterized in that, It consists of the following components by weight percentage: Pyraclostrobin 5%-15%; Tebuconazole 10%-20%; 10%-20% cosolvent; Penetrant 3%-8%; Evaporation inhibitors: 5%-15%; Stabilizer 2%-5%; Add the specific gravity adjuster to 100%.

2. The ultra-low volume liquid formulation containing pyraclostrobin and tebuconazole according to claim 1, characterized in that, The co-solvent is selected from one of N-methylpyrrolidone, dipropylene glycol dimethyl ether (DGBE), dimethyl sulfoxide (DMSO), dihydroglucoside (Cyrene), and γ-butyrolactone (GBL).

3. The ultra-low volume liquid formulation containing pyraclostrobin and tebuconazole according to claim 1, characterized in that, The penetrant is selected from one of fatty alcohol polyoxyethylene ether, alkylphenol polyoxyethylene ether, octylphenol polyoxyethylene ether-10, sorbitan fatty acid ester, and ethylene oxide-propylene oxide block copolymer.

4. The ultra-low volume liquid formulation containing pyraclostrobin and tebuconazole according to claim 1, characterized in that, The evaporation inhibitor is selected from one of the following: vegetable oil ethylene oxide adduct, monochloroethane, dichloroethane, and 1,2-dichloroethane.

5. The ultra-low volume liquid formulation containing pyraclostrobin and tebuconazole according to claim 4, characterized in that, The vegetable oil ethylene oxide adduct is castor oil polyoxyethylene ether or turpentine oil ethylene oxide.

6. The ultra-low volume liquid formulation containing pyraclostrobin and tebuconazole according to claim 1, characterized in that, The stabilizer is selected from one of epoxidized soybean oil, calcium chloride, calcium nitrate, calcium sulfate, and calcium carbonate.

7. The ultra-low volume liquid formulation containing pyraclostrobin and tebuconazole according to claim 1, characterized in that, The specific gravity adjuster is selected from one of triphenyl phosphate, diphenyl phosphate, diisopropylphenyl phosphate, tricresyl phosphate, dioctyl phthalate, and trioctyl trimellitate.

8. The ultra-low volume liquid formulation containing pyraclostrobin and tebuconazole according to claim 1, characterized in that, The physicochemical properties of this ultra-low volume liquid agent meet the following requirements: viscosity (25℃) in the range of 15-25 mPa·s, and surface tension in the range of 25-30 mN / m.

9. The method for preparing the ultra-low volume liquid containing pyraclostrobin and tebuconazole as described in any one of claims 1-8, characterized in that, Includes the following steps: Step S1: Add the formulated amounts of co-solvent and specific gravity adjuster sequentially to the reaction vessel, and start stirring; Step S2: While stirring, slowly add the formulated amounts of pyraclostrobin and tebuconazole to the mixed solvent from step S1, and continue stirring until completely dissolved to form a uniform and transparent solution. Step S3: Add the penetrant, evaporation inhibitor and stabilizer to the drug solution obtained in step S2 in sequence, increase the rotation speed to 300-400 r / min, and stir at a constant temperature for 30-45 minutes to ensure that the system is completely homogeneous; Step S4: Filter the mixture obtained in step S3, and after sampling and testing to ensure it passes the test, the ultra-low volume liquid product is obtained.

10. The method for preparing the ultra-low volume liquid containing pyraclostrobin and tebuconazole according to claim 9, characterized in that, In step S1, the stirring speed is 100-200 r / min.