A rapid film-forming repair composition, its preparation method and application

Abstract

This invention relates to a rapid film-forming repair composition, its preparation method, and its application. The rapid film-forming repair composition comprises: a rapid film-forming repair component, a film softener, a pH adjuster, a preservative, and water. The film-forming repair component includes: Suizenji nori polysaccharide, galactoarabinogalactan, and sodium dextran sulfate. The three components, Suizenji nori polysaccharide, galactoarabinogalactan, and sodium dextran sulfate, interact synergistically to promote skin improvement. Specifically, they can accelerate the formation of a film after application of the active ingredients, effectively conditioning and repairing the skin. Furthermore, they can alleviate skin inflammation and redness, and promote tissue regeneration. The rapid film-forming repair composition provided by this invention is highly suitable for use in skincare products, being gentle, non-irritating, and stable.

Description

Technical Field

[0001] This invention belongs to the field of cosmetic technology and relates to a rapid film-forming repair composition, its preparation method, and its application. Background Technology

[0002] Sensitive skin is a type of problematic skin caused by various factors that trigger an allergic reaction in the skin. It typically affects delicate areas like the face and manifests primarily as itching, peeling, redness, stinging, and even swelling and papules. The exact causes of sensitive skin are not fully understood, but it is the result of multiple factors. These can be categorized into endogenous factors such as race, age, gender, genetics, endocrine factors, and certain diseases, and exogenous factors such as chemical irritants, environmental factors, lifestyle, and psychological factors. Furthermore, improper or excessive use of cosmetics and various beauty treatments can damage the facial skin barrier, making the skin increasingly fragile and sensitive.

[0003] Currently, there are various methods for repairing sensitive skin. Clinical medicine primarily uses hormonal drugs for intervention and treatment, but drug intervention inevitably brings various side effects. There are many skincare cosmetics on the market targeting soothing and anti-allergy repair, but their quality varies and their effects are inconsistent. Therefore, providing a gentle cosmetic that can quickly form a protective barrier to isolate external stimuli and effectively repair sensitive skin has significant application value. Summary of the Invention

[0004] To address the shortcomings of existing technologies, the present invention aims to provide a rapid film-forming repair composition, its preparation method, and its application, specifically providing a rapid film-forming repair composition, its preparation method, and its application in cosmetics.

[0005] To achieve this objective, the present invention adopts the following technical solution:

[0006] In a first aspect, the present invention provides a rapid film-forming and repairing composition, the rapid film-forming and repairing composition comprising: a rapid film-forming and repairing component, a film softener, a pH adjuster, a preservative, and water;

[0007] The film-forming and repairing components include: Suizenji nori polysaccharide, galactoarabinogalactan, and sodium dextran sulfate.

[0008] This invention provides a rapid film-forming repair composition, wherein Suizenji nori polysaccharide can form a dense gel network film, absorbing moisture evaporated from the air or skin to form a film barrier layer, ensuring skin breathability while protecting the skin from external irritation; galactoarabinogalactan is a film-forming agent that can cross-link with Suizenji nori polysaccharide to form a film; sodium dextran sulfate can promote the rapid cross-linking of the aforementioned two components and also has a skin-soothing effect. The combined use of these three components can effectively promote the rapid film formation of the components and efficiently condition the skin.

[0009] Preferably, by weight, the rapid film-forming repair component includes: 1-5 parts of Suizenji nori polysaccharide, 1-5 parts of galactoarabinogalactan, and 1-5 parts of sodium dextran sulfate;

[0010] The "1-5 portions" mentioned above can be, for example, 1 portion, 1.5 portions, 2 portions, 2.5 portions, 3 portions, 3.5 portions, 4 portions, 4.5 portions, 5 portions, etc.

[0011] Preferably, the rapid film-forming repair component also includes Aspergillus / glucose / soybean / starch fermentation product filtrate, glycosphingolipids, and deacetylated chitosan monosuccinamide.

[0012] Furthermore, this invention also found that adding Aspergillus / glucose / soybean / starch fermentation product filtrate, glycosphingolipids, and deacetylated chitosan monosuccinamide to the rapid film-forming repair ingredient further enhances the related skin conditioning effects. Moreover, there is a potential synergistic effect among these three components. The combined use of the three components can effectively condition the skin, relieve skin inflammation and redness, and promote tissue regeneration.

[0013] Preferably, the rapid film-forming repair component further includes: 10-30 parts of Aspergillus / glucose / soybean / starch fermentation product filtrate, 1-5 parts of glycosphingolipids, and 1-5 parts of deacetylated chitosan monosuccinamide;

[0014] The aforementioned "10-30 portions" can be, for example, 10 portions, 12 portions, 14 portions, 15 portions, 18 portions, 20 portions, 22 portions, 25 portions, 26 portions, 30 portions, etc.

[0015] The "1-5 portions" mentioned above can be, for example, 1 portion, 1.5 portions, 2 portions, 2.5 portions, 3 portions, 3.5 portions, 4 portions, 4.5 portions, 5 portions, etc.

[0016] Preferably, the rapid film-forming and repairing composition comprises, by weight, 15-55 parts of the rapid film-forming and repairing component described in the first aspect, 2-5 parts of a film softener, 0.1-1 parts of a pH adjuster, 0.1-1 parts of a preservative, and 30-90 parts of water;

[0017] Among them, "15-55 portions" can be, for example, 15 portions, 20 portions, 30 portions, 35 portions, 40 portions, 50 portions, 55 portions, etc.

[0018] The "2-5 portions" mentioned above can be, for example, 2 portions, 2.5 portions, 3 portions, 3.5 portions, 4 portions, 4.5 portions, 5 portions, etc.

[0019] The aforementioned "0.1-1 part" can be, for example, 0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.8 part, 1 part, etc.;

[0020] The aforementioned "30-90 portions" could be, for example, 30 portions, 40 portions, 50 portions, 60 portions, 70 portions, 80 portions, 90 portions, etc.

[0021] Preferably, the membrane softener is selected from any one or a combination of at least two of glycerol, 1,3-propanediol, methylpropanediol, butanediol, diglycerol, polyethylene glycol-8, or trimethylpentanediol / adipic acid / glycerol crosslinked polymer.

[0022] Preferably, the pH adjuster is selected from any one or a combination of at least two of citric acid, sodium citrate, lactobionic acid, arginine, triethanolamine, tromethamine, or malic acid.

[0023] Preferably, the preservative is selected from any one or a combination of at least two of 1,2-pentanediol, 1,2-hexanediol, p-hydroxyacetophenone, capryloyl hydroxamic acid, glyceryl caprylate, or caprylyl glycol.

[0024] In a second aspect, the present invention provides a method for preparing the rapid film-forming repair composition according to the first aspect, the preparation method comprising the following steps:

[0025] After uniformly mixing the membrane softener, Suizenji nori polysaccharide, and galactoarabinogalactan, a hydrated gel solution was prepared by mixing with water. Sodium dextran sulfate was added for crosslinking. Aspergillus / glucose / soybean / starch fermentation product filtrate, glycosphingolipids, and deacetylated chitosan monosuccinamide were added to the crosslinking solution and mixed. After uniformly dissolving the pH adjuster and preservative, the rapid film-forming and repairing composition was obtained.

[0026] Thirdly, the present invention provides the application of the rapid film-forming repair composition according to the first aspect in cosmetics;

[0027] The cosmetics include lotions, creams, toners, serums, or masks.

[0028] Compared with the prior art, the present invention has the following beneficial effects:

[0029] This invention provides a rapid film-forming repair composition, wherein Suizenji nori polysaccharide can form a dense gel network film, absorbing moisture evaporated from the air or skin to form a film barrier layer, ensuring skin breathability while protecting the skin from external irritation; galactoarabinogalactan is a film-forming agent that can cross-link with Suizenji nori polysaccharide to form a film; sodium dextran sulfate can promote the rapid cross-linking of the aforementioned two components and also has a skin-soothing effect. The combination of these three components can effectively promote the rapid film formation of the ingredients, efficiently condition the skin, and is suitable for use in skin care products. Detailed Implementation

[0030] To further illustrate the technical means and effects of the present invention, the following describes the technical solution of the present invention in conjunction with preferred embodiments of the present invention. However, the present invention is not limited to the scope of the embodiments.

[0031] The following information pertains to the source of the raw materials:

[0032]

[0033] Example 1

[0034] This embodiment provides a rapid film-forming repair composition, the preparation method of which is as follows (the following percentages are by mass):

[0035] (1) Add 2% of Suizenji nori polysaccharide, 1% of galactoarabinogalactan and 3% of membrane softener (trimethylpentanediol / adipic acid / glycerol cross-linked polymer) to the emulsification pot and stir to disperse evenly.

[0036] (2) Add 67.8% water to the emulsifying pot while stirring at medium speed (35 rpm) and homogenizing at low speed (1250 rpm), stop homogenizing, and continue stirring for 40 min until fully hydrated into a viscous gel.

[0037] (3) Add 1% sodium dextran sulfate and stir at low speed (15 rpm) for 35 min until the hydrated glue solution crosslinks into a network structure.

[0038] (4) Add 20% of the Aspergillus / glucose / soybean / starch fermentation product filtrate, 2% of glycosphingolipids, and 2% of deacetylated chitosan monosuccinamide. Stir at low speed (15 rpm) for 25 min. Add 0.2% of pH adjuster (lactobic acid) and stir until dissolved. Add 1% of preservative (1,2-hexanediol: p-hydroxyacetophenone, 1:1, mass ratio) and stir until dissolved. After passing the inspection, discharge the material.

[0039] Example 2

[0040] This embodiment provides a rapid film-forming repair composition, the preparation method of which is as follows (the following percentages are by mass):

[0041] (1) Add 4% of Suizenji nori polysaccharide, 4% of galactoarabinogalactan and 2% of membrane softener (glycerol) to the emulsification pot and stir to disperse evenly.

[0042] (2) Add 50.9% water to the emulsifying pot while stirring at medium speed (30 rpm) and homogenizing at low speed (1500 rpm), stop homogenizing and continue stirring for 50 min until fully hydrated into a viscous gel.

[0043] (3) Add 3% sodium dextran sulfate and stir at low speed (10 rpm) for 40 min until the hydrated glue solution crosslinks into a network structure.

[0044] (4) Add 30% of the Aspergillus / glucose / soybean / starch fermentation product filtrate, 1% of glycosphingolipids, and 4% of deacetylated chitosan monosuccinamide. Stir at low speed (10 rpm) for 25 min. Add 0.5% of pH adjuster (malic acid) and stir until dissolved. Add 0.6% of preservative (1,2-pentanediol) and stir until dissolved. Discharge the material after passing the inspection.

[0045] Example 3

[0046] This embodiment provides a rapid film-forming repair composition, the preparation method of which is as follows (the following percentages are by mass):

[0047] (1) Add 1% of Suizenji nori polysaccharide, 2% of galactoarabinogalactan and 4% of membrane softener (methylpropanediol) to the emulsification pot and stir to disperse evenly.

[0048] (2) Add 69.6% water to the emulsifying pot while stirring at medium speed (40 rpm) and homogenizing at low speed. Stop homogenizing and continue stirring for 30 minutes until fully hydrated into a viscous gel.

[0049] (3) Add 5% sodium dextran sulfate and stir at low speed (20 rpm) for 30 min until the hydrated glue solution crosslinks into a network structure.

[0050] (4) Add 10% of the Aspergillus / glucose / soybean / starch fermentation product filtrate, 5% of glycosphingolipids, and 3% of deacetylated chitosan monosuccinamide. Stir at low speed (20 rpm) for 25 min. Add 0.1% of pH adjuster (arginine) and stir until dissolved. Add 0.3% of preservative (glyceryl caprylate) and stir until dissolved. Discharge the material after passing the inspection.

[0051] Example 4

[0052] This embodiment provides a rapid film-forming repair composition. The difference between its preparation method and that of Example 1 is that the Aspergillus / glucose / soybean / starch fermentation product filtrate is not added in step (4), and the reduced amount is proportionally allocated to glycosphingolipids and deacetylated chitosan monosuccinamide. The addition of other components and the preparation process and parameters are the same as in Example 1.

[0053] Example 5

[0054] This embodiment provides a rapid film-forming repair composition. The only difference between this composition and Example 1 is that glycosphingolipids are not added in step (4), and the reduced amount is proportionally allocated to the Aspergillus / glucose / soybean / starch fermentation product filtrate and deacetylated chitosan monosuccinamide. The addition of other components and the preparation process and parameters are the same as in Example 1.

[0055] Example 6

[0056] This embodiment provides a rapid film-forming repair composition. The only difference between this composition and that of Example 1 is that deacetylated chitosan monosuccinamide is not added in step (4), and the reduced amount is proportionally allocated to glycosphingolipids and Aspergillus / glucose / soybean / starch fermentation product filtrate. The addition of other components and the preparation process and parameters are the same as in Example 1.

[0057] Example 7

[0058] This embodiment provides a rapid film-forming repair composition. The difference between its preparation method and that of Example 1 is that in step (4), the three components Aspergillus / glucose / soybean / starch fermentation product filtrate, glycosphingolipids and deacetylated chitosan monosuccinamide are not added, and their reduced amounts are allocated to water. The addition of other components and the preparation process and parameters are the same as those in Example 1.

[0059] Comparative Example 1

[0060] This comparative example provides a rapid film-forming repair composition. The only difference between this composition and Example 1 is that no Suizenji nori polysaccharide is added in step (1), and the reduced amount is proportionally allocated to galactoarabinogalactan and sodium dextran sulfate. The addition of other components and the preparation process and parameters are the same as in Example 1.

[0061] Comparative Example 2

[0062] This comparative example provides a rapid film-forming repair composition. The only difference between this composition and Example 1 is that galactoarabinogalactan is not added in step (1), and the reduced amount is proportionally allocated to Suizenji nori polysaccharide and sodium dextran sulfate. The addition of other components and the preparation process and parameters are the same as in Example 1.

[0063] Comparative Example 3

[0064] This comparative example provides a rapid film-forming repair composition. The only difference between this composition and Example 1 is that step (3) is omitted, and the reduced amount of sodium dextran sulfate is proportionally allocated to the polysaccharide of Suizenji nori and the galactoarabinogalactan. The addition of other components and the preparation process and parameters are the same as in Example 1.

[0065] Test Example 1

[0066] Membrane continuity and testing

[0067] Take 2 mL of the rapid film-forming repair compositions prepared in Examples 1-7 and Comparative Examples 1-3, add 0.1 mL of 0.1% Red 40 pigment dilution solution, mix well, and spread evenly on a glass slide. Each group is placed in an 80℃ drying oven for 30 min and then the surface morphology of the film is directly observed under an optical microscope. The integrity of the film is evaluated according to the integrity rating criteria of Grade 1 - incomplete with obvious fractures; Grade 2 - basically intact with no obvious fractures; Grade 3 - very intact with dense film formation. The evaluation results are shown in Table 1.

[0068] Table 1

[0069]

[0070] Furthermore, 5 mL of the rapid film-forming repair composition prepared in Examples 1-3 was poured onto a flat polytetrafluoroethylene mold substrate and dried at 80°C for 30 min. The film was then cut into strips of 10 mm × 50 mm. Under constant temperature (25°C) and constant humidity (50%RH) conditions, the tensile strength of the film was tested using a universal testing machine at a tensile speed of 2 mm / min. The results showed that: Example 1 was 10 MPa; Example 2 was 8 MPa; and Example 3 was 9 MPa.

[0071] Based on the test results above, it can be concluded that...

[0072] (1) The rapid film-forming repair composition product prepared by the present invention has excellent film-forming properties, can form a film quickly, and the film has excellent tensile strength.

[0073] (2) Comparing Example 1 with Examples 4-7, the addition of Aspergillus / glucose / soybean / starch fermentation product filtrate, glycosphingolipids and deacetylated chitosan monosuccinamide can also affect the film-forming effect of the essence product to a certain extent.

[0074] (3) According to the comparison between Example 1 and Comparative Examples 1-3, when Comparative Examples 1-3 do not contain any of the three components, namely, Suizenji nori polysaccharide, galactoarabinogalactan and sodium dextran sulfate, the film-forming effect of the essence products prepared by them is worse than that of Example 1. The three components work synergistically to effectively promote the rapid film formation of the relevant components and effectively condition the skin.

[0075] Test Example 2

[0076] Lactic acid irritation test

[0077] (1) Subject selection criteria: aged 18-60 years, healthy male or female, positive lactic acid stinging, healthy and intact skin in the test area on the inner forearm, a total of 80 people, 8 people were randomly assigned to each group.

[0078] (2) Test procedure: Filter paper (0.8±0.1 cm in diameter) soaked in 50 μL of 10% lactic acid solution was simultaneously applied to the inner side of the subject's left and right forearms. When the subject's subjective sensation was moderate or above (recorded as T0), the filter paper was removed, and the stimulation sensation at this time (i.e., the stimulation endpoint, T0) was recorded. 100 μL of the test samples of Examples 1-7 and Comparative Examples 1-3 were used in the sample test area (0.8 cm in diameter), and the product application area completely covered the lactic acid stimulation area.

[0079] (3) Stimulation scores were recorded at 3 min, 6 min and 9 min after the use of the essence sample and were recorded as T3, T6 and T9 respectively. The average value of the results was taken. The evaluation criteria were (0-3 points): 0 points for no stinging sensation, 1 point for mild stinging (tolerable), 2 points for moderate stinging (obvious discomfort), and 3 points for severe stinging (needs to be washed immediately). The evaluation results are shown in Table 2.

[0080] Table 2

[0081]

[0082] According to the data in the table,

[0083] (1) As can be seen from Examples 1 to 3, the rapid film-forming repair composition product prepared by the present invention can quickly form a skin barrier, isolate external adverse stimuli, and quickly calm and repair sensitive skin.

[0084] (2) According to the comparison between Example 1 and Examples 4-7, it can be seen that after adding Aspergillus / glucose / soybean / starch fermentation product filtrate, glycosphingolipids and deacetylated chitosan monosuccinamide to the composition, the combined use of the three components can further condition the skin, relieve redness and promote tissue repair.

[0085] (3) According to the comparison between Example 1 and Comparative Examples 1-3, when Comparative Examples 1-3 do not contain any one of the three components, namely, Suizenji nori polysaccharide, galactoarabinogalactan and sodium dextran sulfate, the skin soothing and repairing effect of the prepared essence products is worse than that of Example 1. It can be seen that the addition of the above three components in the present invention can synergistically improve the skin soothing and repairing effect of the product.

[0086] Test Example 3

[0087] Anti-inflammatory effect test

[0088] (1) Hacat cells were revived and cultured in DMEM complete cell culture medium containing 10% FBS at 37°C in a 5% CO2 incubator;

[0089] Cells were digested with 0.25% trypsin and cultured in DMEM complete medium containing 10% FBS at a cell count of 8.0 × 10⁶ cells per well. 3 The cells were seeded into 96-well plates with a total volume of 100 µL and cultured at 37°C in a 5% CO2 incubator for 24 h. After confirming complete cell adhesion and normal growth under a microscope, the cells were tested.

[0090] (2) With a cell count of 1.5 × 10⁻⁶ per well 4 Hacat cells were seeded at 500 µL / mL in 24-well plates and incubated at 37°C in a 5% CO2 incubator for 24 h. The old culture medium was removed from the wells, and the drugs were administered according to the table below. Each group was set up in 3 replicates.

[0091] Table 3

[0092]

[0093] After culturing for another 24 h, the cell culture supernatant was collected, and the inhibitory effect on the interleukin-6 (IL-6) inflammatory factor was detected and calculated according to the ELISA kit instructions. The results are shown in Table 4.

[0094] Table 4

[0095]

[0096] According to the data in the table, the overall inhibition rate of IL-6 inflammatory factors in Examples 1-3 was higher than that in Comparative Examples 1-3, indicating that the lack of any one of the components of Suizenji nori polysaccharide, galactoarabinogalactan, and sodium dextran sulfate in the composition would reduce the anti-inflammatory effect of the product. The anti-inflammatory effect of Example 1 was better than that of Examples 4-7, indicating that the addition of Aspergillus / glucose / soybean / starch fermentation product filtrate, glycosphingolipids, and deacetylated chitosan monosuccinamide also had a certain synergistic effect in relieving skin inflammation and could further enhance the skin improvement effect of the product.

[0097] Test Example 4

[0098] Security test

[0099] Thirty-five participants were selected according to the inclusion criteria and randomly divided into seven groups (two men and three women per group) to receive the trial. Appropriate amounts of the essence products prepared in Examples 1-7 were placed in a spot tester. The spot tester containing the sample was then applied to the flexor surface of the participant's forearm with medical tape for 24 hours. Skin reactions were observed 30 minutes (after the indentation disappeared), 24 hours, and 48 hours after the spot tester was removed, and the results were recorded. The grading criteria for skin reactions are shown in the table below:

[0100] Table 5

[0101]

[0102] The results showed that the products prepared in Examples 1-7 all exhibited negative reactions at 30 min (after the indentation disappeared), 24 h, and 48 h after the test, with no irritation or erythema. Therefore, the rapid film-forming repair composition product extracted and prepared by this invention is non-irritating to the skin and showed no positive reaction, proving that the product is highly safe, has low irritation, and is relatively mild.

[0103] The applicant declares that the technical solution of this invention is illustrated by the above embodiments, but this invention is not limited to the above embodiments, that is, it does not mean that this invention must rely on the above embodiments to be implemented. Those skilled in the art should understand that any improvements to this invention, equivalent substitutions of raw materials for the products of this invention, addition of auxiliary components, selection of specific methods, etc., all fall within the protection scope and disclosure scope of this invention.

[0104] The preferred embodiments of the present invention have been described in detail above. However, the present invention is not limited to the specific details in the above embodiments. Within the scope of the technical concept of the present invention, various simple modifications can be made to the technical solution of the present invention, and these simple modifications all fall within the protection scope of the present invention.

[0105] It should also be noted that the various specific technical features described in the above specific embodiments can be combined in any suitable manner without contradiction. In order to avoid unnecessary repetition, the present invention will not describe the various possible combinations separately.

Claims

1. A rapid film-forming repair composition, characterized in that, The rapid film-forming and repairing composition comprises: a rapid film-forming and repairing ingredient, a film softener, a pH adjuster, a preservative, and water; By weight, the rapid film-forming repair ingredients include: 1-5 parts of Suizenji nori polysaccharide, 1-5 parts of galactoarabinogalactan, and 1-5 parts of sodium dextran sulfate.

2. The rapid film-forming repair composition according to claim 1, characterized in that, The rapid film-forming repair ingredients also include Aspergillus / glucose / soybean / starch fermentation product filtrate, glycosphingolipids, and deacetylated chitosan monosuccinamide.

3. The rapid film-forming repair composition according to claim 2, characterized in that, By weight, the rapid film-forming repair ingredients also include: 10-30 parts of Aspergillus / glucose / soybean / starch fermentation product filtrate, 1-5 parts of glycosphingolipids, and 1-5 parts of deacetylated chitosan monosuccinamide.

4. The rapid film-forming repair composition according to claim 1, characterized in that, The rapid film-forming and repairing composition comprises, by weight, 15-55 parts of rapid film-forming and repairing ingredients, 2-5 parts of film softener, 0.1-1 parts of pH adjuster, 0.1-1 parts of preservative, and 30-90 parts of water.

5. The rapid film-forming repair composition according to claim 1, characterized in that, The membrane softener is selected from any one or a combination of at least two of the following: glycerol, 1,3-propanediol, methylpropanediol, butanediol, diglycerol, polyethylene glycol-8, or trimethylpentanediol / adipic acid / glycerol crosslinked polymer.

6. The rapid film-forming repair composition according to claim 1, characterized in that, The pH adjuster is selected from any one or a combination of at least two of citric acid, sodium citrate, lactobionic acid, arginine, triethanolamine, tromethamine, or malic acid.

7. The rapid film-forming repair composition according to claim 1, characterized in that, The preservative is selected from any one or a combination of at least two of 1,2-pentanediol, 1,2-hexanediol, p-hydroxyacetophenone, capryloyl hydroxamic acid, glyceryl caprylate, or caprylyl glycol.

8. A method for preparing the rapid film-forming repair composition according to claim 2, characterized in that, The preparation method includes the following steps: After uniformly mixing the membrane softener, Suizenji nori polysaccharide, and galactoarabinogalactan, a hydrated gel solution was prepared by mixing with water. Sodium dextran sulfate was added for crosslinking. Aspergillus / glucose / soybean / starch fermentation product filtrate, glycosphingolipids, and deacetylated chitosan monosuccinamide were added to the crosslinking solution and mixed. After uniformly dissolving the pH adjuster and preservative, the rapid film-forming and repairing composition was obtained.

9. The use of a rapid film-forming repair composition according to any one of claims 1-7 in cosmetics.

Images