Moisturizing and soothing cosmetic containing artemisia apiacea extract and preparation method thereof

Abstract

The invention discloses a moisturizing and soothing cosmetic containing an artemisia apiacea extract and a preparation method of the moisturizing and soothing cosmetic. The cosmetic is prepared from the following raw materials in percentage by weight: 0.5%-2% of 1, 2-hexanediol, 0.3%-1% of p-hydroxyacetophenone, 5%-15% of butanediol, 0.1%-1% of dimethyl sulfone, 0.3%-2% of zanthoxylum armatum extract, 0.2%-1.5% of aesculus chinensis extract, 0.1%-0.5% of dipotassium glycyrrhizinate, 0.5%-3% of panthenol, 0.1%-0.8% of allantoin, 0.1%-1% of oat beta-glucan, 0.05%-0.5% of hydrolyzed sodium hyaluronate, 0.001%-0.01% of caramel color, 0.1%-1% of cyclodextrin, 0.05%-0.3% of acetyl dipeptide-1 cetyl ester, 0.5%-2.5% of scutellaria baicalensis extract, 0.3%-2% of purslane extract and 0.2%-1.5% of a chamomile extract and the balance of deionized water. The traditional Chinese medicine composition has the advantages that various extracts are in synergistic interaction; the safety is high; the composition is suitable for sensitive skin, dry skin and other skin types, and can be prepared into emulsion, face cream, essence and other dosage forms.

Description

Technical Field

[0001] This invention relates to the field of cosmetic technology, and more particularly to moisturizing and soothing cosmetics. Background Technology

[0002] With environmental degradation, increased life stress, and improper skincare habits, sensitivity and dryness caused by damaged skin barriers are becoming increasingly common. Existing moisturizing and soothing cosmetics often have limitations in efficacy (such as short-lasting hydration and weak soothing effects) or pose a risk of irritation. For example, while corticosteroids can quickly soothe inflammation, long-term use can lead to skin atrophy; single plant extracts (such as aloe vera and licorice) often fail to provide both moisturizing and anti-inflammatory benefits simultaneously.

[0003] Flavonoids and polysaccharides in plant extracts can exert their effects by inhibiting the release of inflammatory mediators (such as histamine and interleukins) and promoting skin barrier repair (such as ceramide synthesis), while polyols and peptides can enhance moisturizing capabilities. However, current technologies lack a scientifically sound approach to combine plant extracts with functional ingredients to achieve a synergistic effect of "moisturizing-soothing-repairing." Therefore, developing a moisturizing and soothing composition that is natural, has comprehensive efficacy, and is highly safe is of great significance. Summary of the Invention

[0004] The purpose of this invention is to provide a moisturizing and soothing cosmetic containing artemisia annua extract and its preparation method, in order to solve the problems existing in the prior art, such as the lack of synergy between moisturizing and soothing effects, high irritation of ingredients, and weak ability to repair damaged barriers.

[0005] To achieve the above objectives, the present invention adopts the following technical solution:

[0006] A moisturizing and soothing composition containing Artemisia annua extract, comprising, by weight percentage: 0.5%-3% Artemisia annua extract, 0.5%-2% 1,2-hexanediol, 0.3%-1% p-hydroxyacetophenone, 5%-15% butylene glycol, 0.1%-1% dimethyl sulfone, 0.3%-2% Zanthoxylum bungeanum extract, 0.2%-1.5% Aesculus hippocastanum extract, 0.1%-0.5% dipotassium glycyrrhizate, 0.5%-3% panthenol, 0.1%-0.8% allantoin, 0.1%-1% oat beta-glucan, 0.05%-0.5% hydrolyzed sodium hyaluronate, 0.001%-0.01% caramel color, 0.1%-1% cyclodextrin, and acetyl dipeptide-1. Cetyl ester 0.05%-0.3%, Scutellaria baicalensis extract 0.5%-2.5%, Portulaca oleracea extract 0.3%-2%, Chamomile extract 0.2%-1.5%, with the balance being deionized water.

[0007] Furthermore, the weight ratio of the Scutellaria baicalensis extract, Portulaca oleracea extract, and Chamomile extract is (1-2):(1-1.5):(0.5-1).

[0008] Furthermore, the weight ratio of the Artemisia annua extract, Zanthoxylum bungeanum extract, and Aesculus hippocastanum extract is (1-3):(1-2):(0.5-1).

[0009] Furthermore, the weight ratio of butanediol, panthenol, and hydrolyzed sodium hyaluronate is (10-20):(2-5):(0.1-1).

[0010] Furthermore, the pH value of the composition is 5.0-6.5.

[0011] The present invention also provides a method for preparing the moisturizing and soothing composition containing artemisia annua extract, comprising the following steps:

[0012] S1. Preparation of plant extract mixture: The dried raw materials of Artemisia annua, Zanthoxylum bungeanum, Aesculus hippocastanum, Scutellaria baicalensis, Portulaca oleracea and chamomile were pulverized separately, and added to 50% ethanol aqueous solution at a material-to-liquid ratio of 1g:10mL. The mixture was refluxed at 60-70℃ twice, each time for 1.5-2h. The filtrates were combined and concentrated under reduced pressure to a solid content of 20% to obtain the mixed extract.

[0013] S2. Preparation of aqueous phase: Mix deionized water, butanediol, hydrolyzed sodium hyaluronate, oat β-glucan, and cyclodextrin, heat to 80-85℃, stir until completely dissolved, and sterilize by keeping warm for 30-40 minutes;

[0014] S3. Preparation of active phase: Mix the mixed extract from step S1 with panthenol, allantoin, dipotassium glycyrrhizate, dimethyl sulfone, and acetyl dipeptide-1 cetyl ester, and stir at 40-45℃ until dissolved;

[0015] S4. Compounding and homogenization: Cool the aqueous phase to 45℃, add the active phase, 1,2-hexanediol, p-hydroxyacetophenone, and caramel color, stir evenly, and then homogenize at 3000-3500r / min for 5-10min to obtain the final product.

[0016] Furthermore, in step S1, the plant material is crushed and then passed through a 60-80 mesh sieve.

[0017] Further, in step S4, the pH is adjusted to 5.0-6.5 after homogenization using citric acid or triethanolamine.

[0018] The present invention also provides a moisturizing and soothing cosmetic comprising the composition, wherein the composition is added to the cosmetic at an amount of 5%-20%, and the cosmetic formulation is an essence, lotion, or cream.

[0019] Furthermore, the cosmetic product also contains cosmetically acceptable excipients, including one or more of thickeners, emollients, or antioxidants.

[0020] The advantages of this invention are:

[0021] 1) Synergistic effect: The anti-inflammatory activity of Scutellaria baicalensis extract, the barrier repair effect of Portulaca oleracea extract, and the soothing effect of Chamomile extract complement each other with dipotassium glycyrrhizate and oat β-glucan, significantly improving the moisturizing rate (≥160%) and the inhibition rate of inflammatory factors (≥85%).

[0022] 2) High safety: It does not contain glucocorticoids and uses mild preservatives (1,2-hexanediol, p-hydroxyacetophenone). It has been tested on human patches and is non-irritating.

[0023] 3) Wide applicability: Suitable for various skin types such as sensitive skin and dry skin, and can be formulated into lotion, cream, serum and other dosage forms. Detailed Implementation

[0024] The present invention will be described in detail below with reference to specific embodiments. The illustrative embodiments and descriptions of the present invention are used to explain the present invention, but are not intended to limit the present invention.

[0025] The present invention provides compositions of Examples 1-3 and Comparative Examples 1-2, the components of which are shown in Table 1.

[0026] Table 1

[0027]

[0028] The preparation methods of the moisturizing and soothing compositions in Examples 1-3 and Comparative Examples 1-2 include the following steps:

[0029] S1. Preparation of plant extract mixture: The dried raw materials of Artemisia annua, Zanthoxylum bungeanum, Aesculus hippocastanum, Scutellaria baicalensis, Portulaca oleracea and chamomile were pulverized separately and passed through an 80-mesh sieve. They were then added to a 50% ethanol aqueous solution at a material-to-liquid ratio of 1g:10mL and extracted twice by reflux at 60-70℃ for 2 hours each time. The filtrates were combined and concentrated under reduced pressure to a solid content of 20% to obtain the mixed extract.

[0030] S2. Preparation of aqueous phase: Mix deionized water, butanediol, hydrolyzed sodium hyaluronate, oat β-glucan, and cyclodextrin, heat to 80-85℃, stir until completely dissolved, and sterilize by keeping warm for 30 minutes;

[0031] S3. Preparation of active phase: Mix the mixed extract from step S1 with panthenol, allantoin, dipotassium glycyrrhizate, dimethyl sulfone, and acetyl dipeptide-1 cetyl ester, and stir at 40-45℃ until dissolved;

[0032] S4. Compounding and homogenization: Cool the aqueous phase to 45℃, add the active phase, 1,2-hexanediol, p-hydroxyacetophenone, and caramel color, stir evenly, and homogenize at 3000r / min for 5min using a homogenizer. Adjust the pH to 5.0-6.5 with citric acid or triethanolamine to obtain the final product.

[0033] I. Performance Testing

[0034] 1) In vitro moisturizing performance: Using a skin moisture loss tester (TEWL), the results were tested on the forearms of 30 volunteers with dry skin after 7 consecutive days of use.

[0035] The TEWL values ​​of Examples 1 and 2 decreased by 38.5% and 42.3%, respectively.

[0036] The TEWL values ​​of Comparative Examples 1 and 2 decreased by 15.2% and 22.7%, respectively.

[0037] 2) Anti-inflammatory and soothing properties: Using the hyaluronidase inhibition experiment, the inhibition rates of Examples 1 and 2 were 89.6% and 92.3%, respectively, while those of Comparative Examples 1 and 2 were 35.1% and 62.5%, respectively; In the human lactic acid stinging test, the stinging score reduction rates of Examples 1 and 2 were 72.1% and 78.5%, respectively, which were significantly higher than those of the comparative examples.

[0038] 3) Safety: 30 volunteers with sensitive skin used the product continuously for 28 days. No adverse reactions such as erythema or itching were observed in the first-instance test. In the second-instance test, 3 cases experienced mild stinging.

[0039] This invention significantly enhances the long-lasting moisturizing effect and anti-inflammatory and soothing effect through the synergistic effect of six plant extracts and active ingredients, while maintaining high safety.

[0040] The compositions of Examples 1-2 and Comparative Examples 1-2 were prepared into serum formulations with an addition amount of 10% and tested. The sample size was 30 subjects (sensitive skin / dry skin percentage ≥80%).

[0041] II. Security Testing

[0042] 1. Human patch test (48-hour observation), the results are shown in Table 2.

[0043] Table 2

[0044]

[0045] Conclusion: Examples 1-2, due to the synergistic soothing effect of the six plant extracts, showed significantly lower irritation compared to the control group. (Test result: P < 0.05)

[0046] III. Efficacy Testing

[0047] 1. Transdermal water loss (TEWL) repair test (continuous use for 28 days), the results are shown in Table 3.

[0048] Table 3

[0049]

[0050] Conclusion: The TEWL reduction rate of Examples 1-2 at 28 days was 24.7%-29.4% higher than that of the commercially available control, confirming that the combination of plant extracts significantly enhanced barrier repair (one-way ANOVA, P<0.01).

[0051] 2. The stratum corneum moisture content (Corneometer method, 24 hours after use) is shown in Table 5.

[0052] Table 4

[0053]

[0054] Mechanism verification: LC-MS analysis showed that the combination of oat β-glucan and hydrolyzed sodium hyaluronate in Example 1 increased the content of NMF (natural moisturizing factor) in the stratum corneum by 41.2%, which was significantly higher than that in the comparative example (P < 0.01).

[0055] 3. Soothing and anti-inflammatory test (in vitro + human), results are shown in Table 5.

[0056] Table 5

[0057]

[0058] Conclusion: The combination of Scutellaria baicalensis, Portulaca oleracea, and Chamomile resulted in a higher IL-6 inhibition rate.

[0059] 4. Skin elasticity repair (Cutometer method, used for 28 days), the results are shown in Table 6.

[0060] Table 6

[0061]

[0062] Microscopic evidence: SEM showed that the stratum corneum thickness increased by 22.5% in the Example 1 group, and the intercellular lipids were more tightly arranged, confirming that the extract of horse chestnut + Artemisia annua promoted ceramide synthesis.

[0063] IV. Stability test (40℃ / 7 days, -10℃ / 7 days), the results are shown in Table 7.

[0064] Table 7

[0065]

[0066] Key data: The combination of cyclodextrin and caramel color increased the retention rate of plant polyphenols by 12.3%-20.2% (HPLC detection), confirming the formulation's anti-degradation ability.

[0067] V. User experience testing (50 volunteers, 4 weeks), the results are shown in Table 8.

[0068] Table 8

[0069]

[0070] As can be seen from the results above:

[0071] Synergistic effect: The combination of 6 plant extracts increased the moisturizing rate by 45.6% and the inflammation suppression rate by 29.4%, which was significantly better than comparative examples 1 and 2 (P<0.01).

[0072] Safety: Patch tests in Examples 1-2 showed 0% irritation, while Comparative Example 1 showed a certain degree of irritation due to the lack of plant-based soothing ingredients.

[0073] Stability: Cyclodextrin encapsulation technology makes the active ingredients more stable.

[0074] User value: The immediate relief of Example 1 is 2.7 times that of Example 1, and the long-term satisfaction is high.

[0075] The technical solutions provided by the embodiments of the present invention have been described in detail above. Specific examples have been used to illustrate the principles and implementation methods of the embodiments of the present invention. The descriptions of the embodiments above are only for helping to understand the principles of the embodiments of the present invention. At the same time, for those skilled in the art, there will be changes in the specific implementation methods and application scope based on the embodiments of the present invention. Therefore, the content of this specification should not be construed as a limitation of the present invention.

Claims

1. A moisturizing and soothing composition containing artemisia annua extract, characterized in that, By weight percentage, the ingredients include: Artemisia annua extract 0.5%-3%, 1,2-hexanediol 0.5%-2%, p-hydroxyacetophenone 0.3%-1%, butylene glycol 5%-15%, dimethyl sulfone 0.1%-1%, Zanthoxylum bungeanum extract 0.3%-2%, Aesculus hippocastanum extract 0.2%-1.5%, dipotassium glycyrrhizate 0.1%-0.5%, panthenol 0.5%-3%, allantoin 0.1%-0.8%, oat beta-glucan 0.1%-1%, hydrolyzed sodium hyaluronate 0.05%-0.5%, caramel color 0.001%-0.01%, cyclodextrin 0.1%-1%, acetyl dipeptide-1 Cetyl ester 0.05%-0.3%, Scutellaria baicalensis extract 0.5%-2.5%, Portulaca oleracea extract 0.3%-2%, Chamomile extract 0.2%-1.5%, with the balance being deionized water.

2. The moisturizing and soothing composition containing artemisia annua extract according to claim 1, characterized in that, The weight ratio of the Scutellaria baicalensis extract, Portulaca oleracea extract, and Chamomile extract is (1-2):(1-1.5):(0.5-1).

3. The moisturizing and soothing composition containing artemisia annua extract according to claim 1, characterized in that, The weight ratio of the Artemisia annua extract, Zanthoxylum bungeanum extract, and Aesculus hippocastanum extract is (1-3):(1-2):(0.5-1).

4. The moisturizing and soothing composition containing artemisia annua extract according to claim 1, characterized in that, The weight ratio of butanediol, panthenol, and hydrolyzed sodium hyaluronate is (10-20):(2-5):(0.1-1).

5. The moisturizing and soothing composition containing artemisia annua extract according to claim 1, characterized in that, The pH value of the composition is 5.0-6.

5.

6. A method for preparing a moisturizing and soothing composition containing artemisia annua extract as described in any one of claims 1-5, characterized in that, Includes the following steps: S1. Preparation of plant extract mixture: The dried raw materials of Artemisia annua, Zanthoxylum bungeanum, Aesculus hippocastanum, Scutellaria baicalensis, Portulaca oleracea and chamomile were pulverized separately, and added to 50% ethanol aqueous solution at a material-to-liquid ratio of 1g:10mL. The mixture was refluxed at 60-70℃ twice, each time for 1.5-2h. The filtrates were combined and concentrated under reduced pressure to a solid content of 20% to obtain the mixed extract. S2. Preparation of aqueous phase: Mix deionized water, butanediol, hydrolyzed sodium hyaluronate, oat β-glucan, and cyclodextrin, heat to 80-85℃, stir until completely dissolved, and sterilize by keeping warm for 30-40 minutes; S3. Preparation of active phase: Mix the mixed extract from step S1 with panthenol, allantoin, dipotassium glycyrrhizate, dimethyl sulfone, and acetyl dipeptide-1 cetyl ester, and stir at 40-45℃ until dissolved; S4. Compounding and homogenization: Cool the aqueous phase to 45℃, add the active phase, 1,2-hexanediol, p-hydroxyacetophenone, and caramel color, stir evenly, and then homogenize at 3000-3500r / min for 5-10min to obtain the final product.

7. The method for preparing a moisturizing and soothing cosmetic containing artemisia annua extract according to claim 6, characterized in that, In step S1, the plant material is crushed and then passed through a 60-80 mesh sieve.

8. The method for preparing a moisturizing and soothing cosmetic containing artemisia annua extract according to claim 6, characterized in that, In step S4, the pH is adjusted to 5.0-6.5 after homogenization using citric acid or triethanolamine.

9. A moisturizing and soothing cosmetic comprising the composition of any one of claims 1-5, characterized in that, The composition is added to cosmetics at a rate of 5%-20%, and the cosmetic dosage form is a serum, lotion, or cream.

10. The cosmetic product according to claim 9, characterized in that, The cosmetic product also contains cosmetically acceptable excipients, including one or more of thickeners, emollients, or antioxidants.

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