Oral composition

Abstract

The object of this disclosure is to provide an oral composition containing Rhodiola rosea extract with enhanced antioxidant activity. [Solution] By adding chamomile extract, lavender extract, and / or passionflower extract to an oral composition containing rhodiola extract, the antioxidant effect is improved.

Description

Technical Field

[0001] The present disclosure relates to an oral composition containing rhaponticum extract.

Background Art

[0002] Rhaponticum extract contains various polyphenols and is known to have antioxidant activity (Non-Patent Document 1). Furthermore, rhaponticum extract is known to have anti-anxiety effects, effects of improving falling asleep and maintaining sleep, stress-reducing effects, relaxation-improving effects, performance or concentration-improving effects, effects of improving the effect of rest, and effects of promoting fatigue recovery, and is known to be orally administrable (Patent Document 1).

Prior Art Documents

Non-Patent Documents

[0003]

Non-Patent Document 1

Patent Documents

[0004]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0005] In order to enhance the effectiveness of an oral composition containing rhaponticum extract, a formulation that further enhances its expected antioxidant effect is desired. However, such formulations have not been sufficiently studied.

[0006] Therefore, the present disclosure aims to provide an oral composition containing Rhodiola rosea extract with improved antioxidant activity. [Means for solving the problem]

[0007] The inventors, in order to solve the aforementioned problems, conducted diligent research and unexpectedly discovered that the antioxidant effect was significantly improved by adding chamomile extract, lavender extract, and / or passionflower extract to an oral composition containing Rhodiola rosea extract. This disclosure was completed based on this finding and further research.

[0008] In other words, this disclosure provides inventions in the following embodiments. Item 1. An oral composition comprising (A) Rhodiola rosea extract, and (B) Chamomile extract, lavender extract, and / or passionflower extract. Item 2. The oral composition according to Item 1, comprising 0.005 to 20 parts by weight of component (B) per 1 part by weight of component (A). Item 3. An oral composition according to item 1 or 2, used as an antioxidant. [Effects of the Invention]

[0009] According to this disclosure, an oral composition containing Rhodiola rosea extract with enhanced antioxidant activity is provided. [Modes for carrying out the invention]

[0010] The oral compositions of this disclosure are characterized by containing (A) Rhodiola rosea extract (hereinafter also referred to as "component (A)") and (B) Chamomile extract, lavender extract, and / or passionflower extract (hereinafter also referred to as "component (B)"). The oral compositions of this disclosure will be described in detail below. In this disclosure, the numerical range "X~Y" refers to a range of X or more and Y or less.

[0011] (A) Rhodiola extract The oral composition of the present disclosure contains Apocynum venetum extract as component (A). Although the Apocynum venetum extract has an antioxidant effect, the oral composition of the present disclosure exhibits an antioxidant effect at a level exceeding the antioxidant effect corresponding to the blending amount of the Apocynum venetum extract.

[0012] Apocynum venetum refers to Apocynum venetum L., a plant belonging to the family Apocynaceae. Further, examples of the part of Apocynum venetum (extraction target part) used for the preparation of the Apocynum venetum extract include the whole plant, aerial part, leaves, stems, etc. As the extraction target part, one of these extraction target parts may be used alone, or two or more of them may be used in combination. Among these extraction target parts, from the viewpoint of the antioxidant effect, preferably the leaves of Apocynum venetum can be mentioned.

[0013] Regarding the extraction treatment for obtaining the Apocynum venetum extract, any common extraction method used for the production of plant extracts may be used. For example, solvent extraction treatment, supercritical extraction treatment, steam distillation treatment, etc. can be mentioned. Among these, preferably solvent extraction treatment can be mentioned.

[0014] Examples of the extraction solvent used in the solvent extraction treatment include water; monohydric alcohols having 1 to 6 carbon atoms such as methanol and ethanol; polyhydric alcohols such as propylene glycol and 1,3 - butylene glycol; other polar solvents such as acetone and ethyl acetate; and mixed solvents thereof. Among these extraction solvents, preferably water, monohydric alcohol, and mixed solvents thereof, more preferably water, ethanol, and hydrous ethanol, and still more preferably hydrous ethanol can be mentioned.

[0015] The solvent extraction treatment can be carried out by immersing the part of Apocynum venetum to be extracted, which has been subjected to treatments such as drying, cutting, pulverization, etc. as necessary to enhance the extraction efficiency, in the extraction solvent and stirring as necessary. For example, the solvent extraction treatment can be carried out by immersing it in an extraction solvent having a volume 2 to 100 times the dry weight of the part of Apocynum venetum to be extracted, and carrying out the treatment at, for example, 60°C or higher, preferably at the heating reflux temperature, for about 0.5 to 24 hours.

[0016] After the extraction process, by removing solids through solid-liquid separation, a rough extract is obtained in the form of an extract solution. The obtained extract solution may, if necessary, be subjected to a filtration process; various adsorption treatments such as various chromatography using a column filled with a carrier such as polystyrene gel (polystyrene-divinylbenzene copolymer, etc.), ion exchange resin, activated carbon, etc., and then subjected to a purification process. Also, the obtained extract solution may be used as it is as a non-concentrated extract, or may be subjected to a concentration process as necessary and used as a soft extract, or may further be subjected to a drying process and used as an extract powder.

[0017] The rough extract contains hyperoside and isoquercitrin, which are flavonoid compounds. Examples of the content of hyperoside per 100 parts by weight of the dry weight of the rough extract include, for example, 1 to 10 parts by weight, preferably 1.5 to 10 parts by weight, or 1.5 to 5 parts by weight. Examples of the content of isoquercitrin per 100 parts by weight of the dry weight of the rough extract include, for example, 1 to 10 parts by weight, preferably 1.5 to 10 parts by weight, or 1.5 to 5 parts by weight.

[0018] The content of component (A) in the oral composition of the present disclosure may be appropriately set according to the degree of antioxidant effect required, but in terms of dry weight, for example, it is 15 to 40% by weight, preferably 20 to 30% by weight.

[0019] (B) Chamomile extract, lavender extract, and / or passionflower extract The oral composition of the present disclosure contains chamomile extract, lavender extract, and / or passionflower extract as component (B). Chamomile extract, lavender extract, and passionflower extract all improve the antioxidant effect when combined with component (A) in the oral composition of the present disclosure.

[0020] Chamomile means Matricaria chamomilla, a plant belonging to the Asteraceae family. Also, the part of chamomile (extraction target part) used for the preparation of chamomile extract includes flowers.

[0021] Lavender means Lavandula angustifolia, a plant belonging to the Lamiaceae family. Also, the part of lavender (the extraction target part) used for preparing the lavender extract is the flower.

[0022] Passionflower means Passiflora incarnata, a plant belonging to the Passifloraceae family. Also, the part of passionflower (the extraction target part) used for preparing the passionflower extract is the flower.

[0023] For the extraction process for obtaining each of the chamomile extract, lavender extract, and passionflower extract, any common extraction method used in the production of plant extracts may be employed. Examples include solvent extraction, supercritical extraction, steam distillation, etc. Among these, solvent extraction is preferably used.

[0024] Examples of the extraction solvent used in the solvent extraction process include water; monohydric alcohols having 1 to 6 carbon atoms such as methanol and ethanol; polyhydric alcohols such as propylene glycol and 1,3 - butylene glycol; other polar solvents such as acetone and ethyl acetate; and mixed solvents thereof. Among these extraction solvents, water, monohydric alcohols, and mixed solvents thereof are preferably used, more preferably water, ethanol, and aqueous ethanol, and even more preferably aqueous ethanol.

[0025] The solvent extraction process can be carried out by immersing the above-mentioned extraction target part, which has been subjected to treatments such as drying, cutting, and pulverization as necessary to enhance the extraction efficiency, in the extraction solvent and stirring as necessary. For example, the solvent extraction process can be carried out by immersing it in an extraction solvent that is 2 to 100 times the dry weight of the above-mentioned extraction target part and performing it at, for example, 60°C or higher, preferably at the heating reflux temperature, for about 0.5 to 24 hours.

[0026] After the extraction process, solid matter is removed by solid-liquid separation to obtain chamomile extract, lavender extract, and passionflower extract in the form of extracts. The obtained extracts may be purified as needed by filtration or adsorption treatment using various chromatography methods such as polystyrene gel (polystyrene-divinylbenzene copolymer, etc.), ion exchange resin, or activated carbon columns. The obtained extracts may be used as is as unconcentrated extracts, or they may be subjected to a concentration process as soft extracts as needed, or they may be subjected to a drying process as extract powders.

[0027] Chamomile extract contains apigenin. The total apigenin content per 100 parts by weight of dry chamomile extract is, for example, 0.5 parts by weight or more, preferably 1 part by weight or more, and more preferably 1 to 10 parts by weight.

[0028] Lavender extract contains flavones. The flavones content per 100 parts by weight of dry weight of the lavender extract is, for example, 3 parts by weight or more, preferably 5 parts by weight or more, and more preferably 5 to 20 parts by weight.

[0029] Passionflower extract contains flavonoids. The total flavonoid content per 100 parts by weight of the dry weight of passionflower extract is, for example, 0.5 parts by weight or more, preferably 1 part by weight or more, more preferably 2 parts by weight or more, and even more preferably 2 to 10 parts by weight.

[0030] The oral composition of this disclosure may use one selected from chamomile extract, lavender extract, and passionflower extract as component (B), or two or more in combination.

[0031] In the oral composition of this disclosure, the ratio of component (A) to component (B) is not particularly limited and may be set appropriately according to the desired degree of antioxidant effect. For example, the content of component (B) per 1 part by weight (dry weight) of component (A) (total dry weight) is 0.005 to 20 parts by weight, preferably 0.01 to 5 parts by weight, more preferably 0.03 to 3 parts by weight, even more preferably 0.05 to 2 parts by weight, even more preferably 0.1 to 1 part by weight, and particularly preferably 0.2 to 0.5 parts by weight or 0.2 to 0.4 parts by weight.

[0032] The specific content of component (B) in the oral composition of this disclosure is determined by the content of component (A) and the ratio of component (A) to component (B), but preferably by total dry weight of 0.3 to 25% by weight, more preferably 3 to 20% by weight, more preferably 5 to 15% by weight or 5 to 10% by weight.

[0033] Other ingredients The oral compositions of this disclosure may or may not contain other nutritional and / or pharmacological components in addition to the components (A) and (B) described above. Such optional nutritional and / or pharmacological components are not particularly limited as long as they are usable in food or oral medicine, but examples include vitamins, amino acids, minerals, carbohydrates, fatty acids, other plant extracts, other antioxidants, hypoglycemic agents, anticholinergic agents, and immunostimulants. These components may be used individually or in combination of two or more. The content of these components may be appropriately determined depending on the type of additive used or the intended use of the oral composition.

[0034] Furthermore, the oral compositions of this disclosure may or may not contain, in addition to the aforementioned components (A) and (B), a base and / or additives, as necessary, in order to prepare them into a desired formulation. Such bases and / or additives, whether present or absent, are not particularly limited as long as they are usable in food or oral pharmaceuticals, but examples include excipients, disintegrants, lubricants, binders, thickeners, monohydric alcohols with 1 to 5 carbon atoms, higher alcohols with 6 or more carbon atoms, oils and fats, water-soluble polymers, surfactants, polyhydric alcohols, pH adjusters, buffers, antioxidants, preservatives, chelating agents, water, etc. These components may be used individually or in combination of two or more. The content of these components is appropriately determined according to the type of base and / or additive used and the dosage form of the oral composition.

[0035] Dosage form / form The dosage form of the oral composition of this disclosure is not particularly limited as long as it can be taken orally, and may be solid (specifically, powder, granules, tablets, capsules, etc.), semi-solid (specifically, paste, gel, etc.), or liquid. Of these dosage forms, a solid form is preferred from the viewpoint of stability, etc.

[0036] The formulation of the oral composition of this disclosure is not particularly limited as long as it can be taken orally, and may be either food or pharmaceutical, but food is preferred. Examples of food and beverages include foods for special dietary uses and health functional foods (nutrient function foods, foods with functional claims, foods for specified health uses, etc.), and general foods (nutritional supplements, health supplements, fortified foods, nutritional adjustment foods, supplements, etc.). Food and beverages include food and beverages for human use and feed for non-human animals (livestock feed, livestock supplements, pet food, pet supplements, etc.).

[0037] Purpose The oral compositions of this disclosure can be used in applications that utilize the known effects of Rhodiola rosea extract, and / or applications that utilize the known effects of chamomile extract, lavender extract, and / or passionflower extract. The oral compositions of this disclosure are preferably used as antioxidants because they exhibit an antioxidant effect that significantly exceeds the antioxidant effect equivalent to that of the amount of Rhodiola rosea extract used.

[0038] More specific uses of the oral composition disclosed herein include improving sleep quality, improving satisfaction with sleep upon waking, improving sleep onset, improving sleep maintenance, anti-anxiety effects, stress reduction, improved relaxation, improved performance, improved concentration, improved rest effects, accelerated fatigue recovery, improvement of temporary mood swings before menstruation, and improvement of menstrual discomfort. [Examples]

[0039] The present disclosure will be described in detail below with reference to examples, but the present disclosure is not limited to these examples.

[0040] Test example Following the procedure for the DPPH antioxidant capacity measurement kit (Dojin Chemical Laboratories), assay buffer (included in the kit) and DPPH (1,1-diphenyl-2-picrylhydrazyl) solution were added to a 96-well microplate, and then the components listed in Table 1 were added to reach the final concentrations indicated. For the Rhodiola rosea extract, a dried powder of the extract obtained by heating and refluxing dried Rhodiola rosea leaves with aqueous ethanol (containing 2% by weight of hyperoside and 2% by weight of isoquercitrin) was used. For the Chamomile extract, a dried powder of the extract obtained by extracting dried chamomile flowers with aqueous ethanol (total apigenin 1.2% or more by weight) was used. For the Lavender extract, a dried powder of the extract obtained by extracting dried lavender flowers with aqueous ethanol (flavones 5% or more by weight) was used. For the Passionflower extract, a dried powder of the extract obtained by extracting dried passionflower flowers with aqueous ethanol (total flavonoids 3% or more by weight) was used.

[0041] DPPH is a stable, purple radical compound that becomes colorless upon reduction by antioxidants. The absorbance at 517 nm (at 25°C, 30 minutes after the start of measurement) was measured using a plate reader. The radical scavenging rate was evaluated as the antioxidant activity value based on the following formula. The results are shown in Table 1.

[0042] [ka]

[0043] [Table 1]

[0044] As shown in Table 1, chamomile extract, lavender extract, and passionflower extract all showed only slight antioxidant activity (Comparative Examples 2-4). However, compared to the antioxidant activity of Rhodiola rosea extract alone (Comparative Example 1), the antioxidant activity was significantly improved when Rhodiola rosea extract was combined with chamomile extract, lavender extract, or passionflower extract (Examples 1-3).

[0045] Prescription examples Tablet compositions were prepared according to the formulations shown in Table 2, and 230 mg tablets were prepared. All tablets exhibited improved antioxidant effects due to the inclusion of chamomile extract, lavender extract, or passionflower extract.

[0046] [Table 2]

Claims

1. An oral composition comprising (A) Rhodiola rosea extract, and (B) Chamomile extract, lavender extract, and / or passionflower extract.

2. The oral composition according to claim 1, comprising 0.005 to 20 parts by weight of component (B) per 1 part by weight of component (A).

3. An oral composition according to claim 1 or 2, used as an antioxidant.

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